H Karst

Summary

Affiliation: University of Amsterdam
Country: The Netherlands

Publications

  1. ncbi request reprint Calcium currents in rat dentate granule cells are altered after adrenalectomy
    H Karst
    Swammerdam Institute for Life Sciences, University of Amsterdam, Kruislaan 320, 1098 SM Amsterdam, The Netherlands
    Eur J Neurosci 14:503-12. 2001
  2. ncbi request reprint Brief RU 38486 treatment normalizes the effects of chronic stress on calcium currents in rat hippocampal CA1 neurons
    Henk Karst
    SILS CNS, University of Amsterdam, Amsterdam, The Netherlands
    Neuropsychopharmacology 32:1830-9. 2007
  3. pmc Mineralocorticoid receptors are indispensable for nongenomic modulation of hippocampal glutamate transmission by corticosterone
    Henk Karst
    Swammerdam Institute for Life Sciences, Center for Neurosciences SILS CNS, University of Amsterdam, Kruislaan 320, 1098 SM Amsterdam, The Netherlands
    Proc Natl Acad Sci U S A 102:19204-7. 2005
  4. ncbi request reprint Corticosterone slowly enhances miniature excitatory postsynaptic current amplitude in mice CA1 hippocampal cells
    Henk Karst
    Center for Neuroscience, Swammerdam Institute for Life Sciences, University of Amsterdam, Kruislaan 320, 1098 SM Amsterdam, The Netherlands
    J Neurophysiol 94:3479-86. 2005
  5. ncbi request reprint Acute stress increases calcium current amplitude in rat hippocampus: temporal changes in physiology and gene expression
    M Joels
    Swammerdam Institute for Life Sciences, University of Amsterdam, Kruislaan 320, 1098 SM Amsterdam, The Netherlands
    Eur J Neurosci 18:1315-24. 2003
  6. ncbi request reprint Rapid changes in hippocampal CA1 pyramidal cell function via pre- as well as postsynaptic membrane mineralocorticoid receptors
    J E Olijslagers
    SILS CNS, University of Amsterdam, Kruislaan 320, 1098 SM Amsterdam, The Netherlands
    Eur J Neurosci 27:2542-50. 2008
  7. ncbi request reprint Episodic corticosterone treatment accelerates kindling epileptogenesis and triggers long-term changes in hippocampal CA1 cells, in the fully kindled state
    H Karst
    Department of Exp Zoology, University of Amsterdam, Kruislaan 320, 1098 SM Amsterdam, The Netherlands
    Eur J Neurosci 11:889-98. 1999
  8. ncbi request reprint Corticosteroid actions in hippocampus require DNA binding of glucocorticoid receptor homodimers
    H Karst
    Inst Neurobiology, University of Amsterdam, Kruislaan 320, 1098 SM Amsterdam, The Netherlands
    Nat Neurosci 3:977-8. 2000
  9. ncbi request reprint Chronic unpredictable stress alters gene expression in rat single dentate granule cells
    Yongjun Qin
    Section Neurobiology, Swammerdam Institute for Life Sciences, Faculty of Science, University of Amsterdam, Amsterdam, The Netherlands
    J Neurochem 89:364-74. 2004
  10. ncbi request reprint Hippocampal cell responses in mice with a targeted glucocorticoid receptor gene disruption
    W Hesen
    Department of Experimental Zoology, University of Amsterdam, 1098 SM Amsterdam, The Netherlands
    J Neurosci 16:6766-74. 1996

Collaborators

Detail Information

Publications27

  1. ncbi request reprint Calcium currents in rat dentate granule cells are altered after adrenalectomy
    H Karst
    Swammerdam Institute for Life Sciences, University of Amsterdam, Kruislaan 320, 1098 SM Amsterdam, The Netherlands
    Eur J Neurosci 14:503-12. 2001
    ..The data indicate that cellular calcium current characteristics of dentate granule cells are altered after adrenalectomy and that the alterations may in part determine the vulnerability to undergo apoptosis...
  2. ncbi request reprint Brief RU 38486 treatment normalizes the effects of chronic stress on calcium currents in rat hippocampal CA1 neurons
    Henk Karst
    SILS CNS, University of Amsterdam, Amsterdam, The Netherlands
    Neuropsychopharmacology 32:1830-9. 2007
    ..In conclusion, the data indicate that chronic stress, RU 38486 treatment as well as acute rises in corticosterone level strongly modulate calcium influx into CA1 neurons. This could have consequences for the viability of these neurons...
  3. pmc Mineralocorticoid receptors are indispensable for nongenomic modulation of hippocampal glutamate transmission by corticosterone
    Henk Karst
    Swammerdam Institute for Life Sciences, Center for Neurosciences SILS CNS, University of Amsterdam, Kruislaan 320, 1098 SM Amsterdam, The Netherlands
    Proc Natl Acad Sci U S A 102:19204-7. 2005
    ..Rapid actions by corticosterone would allow the brain to change its function within minutes after stress-induced elevations of corticosteroid levels, in addition to responding later through gene-mediated signaling pathways...
  4. ncbi request reprint Corticosterone slowly enhances miniature excitatory postsynaptic current amplitude in mice CA1 hippocampal cells
    Henk Karst
    Center for Neuroscience, Swammerdam Institute for Life Sciences, University of Amsterdam, Kruislaan 320, 1098 SM Amsterdam, The Netherlands
    J Neurophysiol 94:3479-86. 2005
    ..In summary, the present results show that activation of hippocampal glucocorticoid receptors induces a slow enhancement of AMPA-receptor-mediated responses, at the single-cell level...
  5. ncbi request reprint Acute stress increases calcium current amplitude in rat hippocampus: temporal changes in physiology and gene expression
    M Joels
    Swammerdam Institute for Life Sciences, University of Amsterdam, Kruislaan 320, 1098 SM Amsterdam, The Netherlands
    Eur J Neurosci 18:1315-24. 2003
    ..Prior to the functional change, increased expression of calcium channel subunits was observed, suggesting that the enhanced function could be explained by transcriptional regulation of the channels...
  6. ncbi request reprint Rapid changes in hippocampal CA1 pyramidal cell function via pre- as well as postsynaptic membrane mineralocorticoid receptors
    J E Olijslagers
    SILS CNS, University of Amsterdam, Kruislaan 320, 1098 SM Amsterdam, The Netherlands
    Eur J Neurosci 27:2542-50. 2008
    ..Through these dual pathways, high corticosterone concentrations such as occur after stress could contribute to enhanced CA1 pyramidal excitability...
  7. ncbi request reprint Episodic corticosterone treatment accelerates kindling epileptogenesis and triggers long-term changes in hippocampal CA1 cells, in the fully kindled state
    H Karst
    Department of Exp Zoology, University of Amsterdam, Kruislaan 320, 1098 SM Amsterdam, The Netherlands
    Eur J Neurosci 11:889-98. 1999
    ....
  8. ncbi request reprint Corticosteroid actions in hippocampus require DNA binding of glucocorticoid receptor homodimers
    H Karst
    Inst Neurobiology, University of Amsterdam, Kruislaan 320, 1098 SM Amsterdam, The Netherlands
    Nat Neurosci 3:977-8. 2000
    ..Here we show that at least some of these actions require DNA binding of glucocorticoid receptor (GR) homodimers...
  9. ncbi request reprint Chronic unpredictable stress alters gene expression in rat single dentate granule cells
    Yongjun Qin
    Section Neurobiology, Swammerdam Institute for Life Sciences, Faculty of Science, University of Amsterdam, Amsterdam, The Netherlands
    J Neurochem 89:364-74. 2004
    ..This could contribute to enhanced excitability and vulnerability of granule cells after chronic stress...
  10. ncbi request reprint Hippocampal cell responses in mice with a targeted glucocorticoid receptor gene disruption
    W Hesen
    Department of Experimental Zoology, University of Amsterdam, 1098 SM Amsterdam, The Netherlands
    J Neurosci 16:6766-74. 1996
    ..These findings exemplify the use of GR knockout mice for the study of cellular properties in the brain. Further substantiation of the observations, however, awaits the development of site-specific, inducible GR knockouts...
  11. ncbi request reprint Morphological and functional properties of rat dentate granule cells after adrenalectomy
    J Wossink
    Swammerdam Institute of Life Sciences, University of Amsterdam, Kruislaan 320, 1098 SM Amsterdam, The Netherlands
    Neuroscience 108:263-72. 2001
    ..Our data indicate that in the absence of corticosterone dendritic trees of dentate granule cells display atrophy but that this does not necessarily reduce ionic currents measured in the soma...
  12. ncbi request reprint GABAergic transmission in the rat paraventricular nucleus of the hypothalamus is suppressed by corticosterone and stress
    J Martin Verkuyl
    Swammerdam Institute for Life Sciences, Section Neurobiology, University of Amsterdam, Kruislaan 320, 1098 SM Amsterdam, The Netherlands
    Eur J Neurosci 21:113-21. 2005
    ....
  13. ncbi request reprint Differential effects of corticosterone on the slow afterhyperpolarization in the basolateral amygdala and CA1 region: possible role of calcium channel subunits
    Lutz Liebmann
    Swammerdam Institute for Life Sciences, Center for Neuroscience, University of Amsterdam, Amsterdam, The Netherlands
    J Neurophysiol 99:958-68. 2008
    ....
  14. ncbi request reprint Effect of chronic stress on synaptic currents in rat hippocampal dentate gyrus neurons
    Henk Karst
    Swammerdam Institute for Life Sciences, University of Amsterdam, The Netherlands
    J Neurophysiol 89:625-33. 2003
    ..This enhanced synaptic flow could contribute to enhanced excitation of projection areas of the dentate gyrus, most notably the CA3 hippocampal region...
  15. ncbi request reprint Glucocorticoids alter calcium conductances and calcium channel subunit expression in basolateral amygdala neurons
    Henk Karst
    Section Neurobiology, Swammerdam Institute for Life Sciences, University of Amsterdam, the Netherlands Department Pharmacology and Toxicology, University of Texas Medical Branch, Galveston, USA
    Eur J Neurosci 16:1083-9. 2002
    ..These actions could modify amygdala network function and thus contribute to the behavioural effects exerted by the stress hormones via the basolateral amygdala...
  16. ncbi request reprint Opposite effects of glucocorticoid receptor activation on hippocampal CA1 dendritic complexity in chronically stressed and handled animals
    D N Alfarez
    Swammerdam Institute for Life Sciences, Center for Neuroscience, Universiteit van Amsterdam, Kruislaan 320, 1098 SM, Amsterdam, The Netherlands
    Hippocampus 18:20-8. 2008
    ....
  17. doi request reprint Corticosteroid effects on cellular physiology of limbic cells
    Marian Joels
    SILS CNS, University of Amsterdam, Kruislaan 320, 1098 SM Amsterdam, The Netherlands
    Brain Res 1293:91-100. 2009
    ..Finally, the time- and region-specific corticosteroid actions strongly depend on the individual's life history...
  18. ncbi request reprint The coming out of the brain mineralocorticoid receptor
    Marian Joels
    SILS CNS, University of Amsterdam, 1098 SM Amsterdam, The Netherlands
    Trends Neurosci 31:1-7. 2008
    ..This concept may explain why human carriers of a mineralocorticoid receptor gene variant display enhanced neuroendocrine and autonomic responsiveness to a psychological stressor...
  19. ncbi request reprint Stress-induced changes in hippocampal function
    Marian Joels
    SILS CNS, University of Amsterdam, Amsterdam, The Netherlands
    Prog Brain Res 167:3-15. 2008
    ....
  20. ncbi request reprint Chronic stress: implications for neuronal morphology, function and neurogenesis
    Marian Joels
    SILS CNS, University of Amsterdam, Kruislaan 320, 1098 SM Amsterdam, The Netherlands
    Front Neuroendocrinol 28:72-96. 2007
    ....
  21. ncbi request reprint Effects of chronic stress on structure and cell function in rat hippocampus and hypothalamus
    Marian Joels
    SILS CNS, University of Amsterdam, The Netherlands
    Stress 7:221-31. 2004
    ..All of these endpoints provide potential targets for novel treatment strategies of stress-related brain disorders...
  22. ncbi request reprint Corticosterone shifts different forms of synaptic potentiation in opposite directions
    Harm J Krugers
    Swammerdam Institute for Life Sciences, Center for Neuroscience, University of Amsterdam, The Netherlands
    Hippocampus 15:697-703. 2005
    ..We speculate that these opposite effects on synaptic efficacy are involved in the bidirectional modulation of cognitive performance by corticosteroid hormones...
  23. ncbi request reprint Gene expression patterns in rat dentate granule cells: comparison between fresh and fixed tissue
    Yongjun Qin
    Section Neurobiology, Swammerdam Institute for Life Sciences, University of Amsterdam, Kruislaan 320, 1098SM Amsterdam, The Netherlands
    J Neurosci Methods 131:205-11. 2003
    ..The present approach validates expression profiling from small amounts of fixed neurons as a powerful tool to investigate molecular processes if fresh tissue is not available...
  24. ncbi request reprint Gene expression changes in single dentate granule neurons after adrenalectomy of rats
    Yongjun Qin
    Swammerdam Institute for Life Science, Section Neurobiology, University of Amsterdam, Kruislaan 320, 1098 SM Amsterdam, The Netherlands
    Brain Res Mol Brain Res 111:17-23. 2003
    ....
  25. doi request reprint Effects of corticosterone and the beta-agonist isoproterenol on glutamate receptor-mediated synaptic currents in the rat basolateral amygdala
    Lutz Liebmann
    SILS CNS, University of Amsterdam, Amsterdam, The Netherlands
    Eur J Neurosci 30:800-7. 2009
    ....
  26. pmc Dissociation between rat hippocampal CA1 and dentate gyrus cells in their response to corticosterone: effects on calcium channel protein and current
    Neeltje G van Gemert
    Swammerdam Institute for Life Sciences, University of Amsterdam, 1098 SM Amsterdam, The Netherlands
    Endocrinology 150:4615-24. 2009
    ....
  27. ncbi request reprint Corticosteroid hormones in the central stress response: quick-and-slow
    E Ronald de Kloet
    Department of Medical Pharmacology, LACDR, Leiden University Medical Center, PO Box 9502, 2300 RA Leiden, The Netherlands
    Front Neuroendocrinol 29:268-72. 2008
    ..The fast effects are complemented by slower glucocorticoid receptor-mediated effects which facilitate suppression of temporary raised excitability, recovery from the stressful experience and storage of information for future use...