Harm H Kampinga

Summary

Affiliation: University Medical Center Groningen
Country: The Netherlands

Publications

  1. ncbi request reprint Cell biological effects of hyperthermia alone or combined with radiation or drugs: a short introduction to newcomers in the field
    Harm H Kampinga
    Department of Cell Biology, Section of Radiation and Stress Cell Biology, University of Groningen, UMCG, Groningen, The Netherlands
    Int J Hyperthermia 22:191-6. 2006
  2. pmc Guidelines for the nomenclature of the human heat shock proteins
    Harm H Kampinga
    Department of Cell Biology, Section of Radiation and Stress Cell Biology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    Cell Stress Chaperones 14:105-11. 2009
  3. pmc The HSP70 chaperone machinery: J proteins as drivers of functional specificity
    Harm H Kampinga
    Department of Cell Biology, University of Groningen, University Medical Center, 713 AV Groningen, The Netherlands
    Nat Rev Mol Cell Biol 11:579-92. 2010
  4. pmc Beat shock proteins and atrial fibrillation
    Harm H Kampinga
    Department of Cell Biology, Clinical Pharmacology, and Cardiology, University Medical Center Groningen and University of Groningen, The Netherlands
    Cell Stress Chaperones 12:97-100. 2007
  5. pmc Computational analysis of the human HSPH/HSPA/DNAJ family and cloning of a human HSPH/HSPA/DNAJ expression library
    Jurre Hageman
    Section of Radiation and Stress Cell Biology, Department of Cell Biology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    Cell Stress Chaperones 14:1-21. 2009
  6. pmc Stwl modifies chromatin compaction and is required to maintain DNA integrity in the presence of perturbed DNA replication
    Xia Yi
    Department of Radiation and Stress Cell Biology, Division of Cell Biology, University Medical Center Groningen, University of Groningen, 9713 AV Groningen, The Netherlands
    Mol Biol Cell 20:983-94. 2009
  7. doi request reprint Effects of different small HSPB members on contractile dysfunction and structural changes in a Drosophila melanogaster model for Atrial Fibrillation
    Deli Zhang
    Department of Clinical Pharmacology, University Institute for Drug Exploration, University of Groningen, University Medical Center Groningen, The Netherlands
    J Mol Cell Cardiol 51:381-9. 2011
  8. pmc A long-term flow cytometry assay to analyze the role of specific genes of Drosophila melanogaster S2 cells in surviving genotoxic stress
    Xia Yi
    Department of Radiation and Stress Cell Biology, Division of Cell Biology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    Cytometry A 73:637-42. 2008
  9. doi request reprint HSPB7 is the most potent polyQ aggregation suppressor within the HSPB family of molecular chaperones
    Michel J Vos
    Department of Cell Biology, Section of Radiation and Stress Cell Biology, University of Groningen, Ant Deusinglaan 1, Groningen, The Netherlands
    Hum Mol Genet 19:4677-93. 2010
  10. pmc Identification of the Drosophila ortholog of HSPB8: implication of HSPB8 loss of function in protein folding diseases
    Serena Carra
    Department of Radiation and Stress Cell Biology, University Medical Center Groningen, A Deusinglaan 1, 9713 AV Groningen, The Netherlands
    J Biol Chem 285:37811-22. 2010

Collaborators

Detail Information

Publications65

  1. ncbi request reprint Cell biological effects of hyperthermia alone or combined with radiation or drugs: a short introduction to newcomers in the field
    Harm H Kampinga
    Department of Cell Biology, Section of Radiation and Stress Cell Biology, University of Groningen, UMCG, Groningen, The Netherlands
    Int J Hyperthermia 22:191-6. 2006
    ..This may be why cells with acquired drug resistance (often multi-factorial) can be made responsive to drugs again by combining the drug treatment with heat...
  2. pmc Guidelines for the nomenclature of the human heat shock proteins
    Harm H Kampinga
    Department of Cell Biology, Section of Radiation and Stress Cell Biology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    Cell Stress Chaperones 14:105-11. 2009
    ..In addition to this nomenclature, we provide a list of the human Entrez Gene IDs and the corresponding Entrez Gene IDs for the mouse orthologs...
  3. pmc The HSP70 chaperone machinery: J proteins as drivers of functional specificity
    Harm H Kampinga
    Department of Cell Biology, University of Groningen, University Medical Center, 713 AV Groningen, The Netherlands
    Nat Rev Mol Cell Biol 11:579-92. 2010
    ..Some target HSP70 activity to clients at precise locations in cells and others bind client proteins directly, thereby delivering specific clients to HSP70 and directly determining their fate...
  4. pmc Beat shock proteins and atrial fibrillation
    Harm H Kampinga
    Department of Cell Biology, Clinical Pharmacology, and Cardiology, University Medical Center Groningen and University of Groningen, The Netherlands
    Cell Stress Chaperones 12:97-100. 2007
    ..However, both correlative studies in human and experimental studies suggest that Hsp27 (HspB1) may delay progression of AF to the more permanent forms and hence Hsp27 might be referred to as a "Beat shock protein"...
  5. pmc Computational analysis of the human HSPH/HSPA/DNAJ family and cloning of a human HSPH/HSPA/DNAJ expression library
    Jurre Hageman
    Section of Radiation and Stress Cell Biology, Department of Cell Biology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    Cell Stress Chaperones 14:1-21. 2009
    ....
  6. pmc Stwl modifies chromatin compaction and is required to maintain DNA integrity in the presence of perturbed DNA replication
    Xia Yi
    Department of Radiation and Stress Cell Biology, Division of Cell Biology, University Medical Center Groningen, University of Groningen, 9713 AV Groningen, The Netherlands
    Mol Biol Cell 20:983-94. 2009
    ....
  7. doi request reprint Effects of different small HSPB members on contractile dysfunction and structural changes in a Drosophila melanogaster model for Atrial Fibrillation
    Deli Zhang
    Department of Clinical Pharmacology, University Institute for Drug Exploration, University of Groningen, University Medical Center Groningen, The Netherlands
    J Mol Cell Cardiol 51:381-9. 2011
    ..Thus, tachypaced D. melanogaster can be used as an in vivo model system for rapid identification of novel targets to combat AF associated cardiomyocyte remodeling...
  8. pmc A long-term flow cytometry assay to analyze the role of specific genes of Drosophila melanogaster S2 cells in surviving genotoxic stress
    Xia Yi
    Department of Radiation and Stress Cell Biology, Division of Cell Biology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    Cytometry A 73:637-42. 2008
    ..Our assay will be of use to investigate the long-term effects of various treatments in S2 cells and to evaluate the role of specific proteins therein...
  9. doi request reprint HSPB7 is the most potent polyQ aggregation suppressor within the HSPB family of molecular chaperones
    Michel J Vos
    Department of Cell Biology, Section of Radiation and Stress Cell Biology, University of Groningen, Ant Deusinglaan 1, Groningen, The Netherlands
    Hum Mol Genet 19:4677-93. 2010
    ..Hence, HSPB7 prevents toxicity of polyQ proteins at an early stage of aggregate formation by a non-canonical mechanism that requires an active autophagy machinery...
  10. pmc Identification of the Drosophila ortholog of HSPB8: implication of HSPB8 loss of function in protein folding diseases
    Serena Carra
    Department of Radiation and Stress Cell Biology, University Medical Center Groningen, A Deusinglaan 1, 9713 AV Groningen, The Netherlands
    J Biol Chem 285:37811-22. 2010
    ..Our current data further support the link between the HSPB8-BAG3 complex, autophagy, and folding diseases and demonstrate that impairment or loss of function of HSPB8 might accelerate the progression and/or severity of folding diseases...
  11. ncbi request reprint The impact of heart irradiation on dose-volume effects in the rat lung
    Peter van Luijk
    Department of Radiation Oncology, University Medical Center, Groningen, The Netherlands
    Int J Radiat Oncol Biol Phys 69:552-9. 2007
    ..To test the hypothesis that heart irradiation increases the risk of a symptomatic radiation-induced loss of lung function (SRILF) and that this can be well-described as a modulation of the functional reserve of the lung...
  12. pmc HSPB1, HSPB6, HSPB7 and HSPB8 protect against RhoA GTPase-induced remodeling in tachypaced atrial myocytes
    Lei Ke
    Department of Radiation and Stress Cell Biology, University Institute for Drug Exploration GUIDE, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands
    PLoS ONE 6:e20395. 2011
    ..Furthermore, modulating effects of HSPB on RhoA GTPase activity and F-actin stress fiber formation were examined, as this pathway was found of prime importance in tachycardia remodeling events and the initiation of AF...
  13. doi request reprint Enhanced proliferation of acinar and progenitor cells by prophylactic pilocarpine treatment underlies the observed amelioration of radiation injury to parotid glands
    Fred R Burlage
    Department of Radiation Oncology, University Medical Center Groningen, The Netherlands
    Radiother Oncol 90:253-6. 2009
    ..In this study, this hypothesis is tested directly, by assessing the proliferation of progenitor and secretory cells in irradiated and non-irradiated parotid gland tissue...
  14. doi request reprint Keratinocyte growth factor prevents radiation damage to salivary glands by expansion of the stem/progenitor pool
    Isabelle M A Lombaert
    Department of Cell Biology, Section Radiation and Stress Cell Biology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    Stem Cells 26:2595-601. 2008
    ..Disclosure of potential conflicts of interest is found at the end of this article...
  15. ncbi request reprint Changes in expression of injury after irradiation of increasing volumes in rat lung
    Alena Novakova-Jiresova
    Department of Cell Biology, Section of Radiation and Stress Cell Biology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    Int J Radiat Oncol Biol Phys 67:1510-8. 2007
    ..This study investigated the relative dose-volume sensitivity, underlying pathologic findings, and consequentiality of early to late pathologic features...
  16. doi request reprint Synergistic induction of profibrotic PAI-1 by TGF-β and radiation depends on p53
    Maarten Niemantsverdriet
    Department of Cell Biology, University Medical Center Groningen, University of Groningen, The Netherlands
    Radiother Oncol 97:33-5. 2010
    ..Here, we demonstrate that p53 is both indispensable and sufficient for the radiation effect inducing synergistic activation of PAI-1 by radiation and TGF-β...
  17. doi request reprint Calpain mediates cardiac troponin degradation and contractile dysfunction in atrial fibrillation
    Lei Ke
    Department of Radiation and Stress Cell Biology, University Institute for Drug Exploration GUIDE, University of Groningen, University Medical Center Groningen, The Netherlands
    J Mol Cell Cardiol 45:685-93. 2008
    ..Our results suggest that calpain inhibition may therefore represent a key target in combating AF-related structural and functional remodeling...
  18. doi request reprint Cytokine treatment improves parenchymal and vascular damage of salivary glands after irradiation
    Isabelle M A Lombaert
    Section of Radiation and Stress Cell Biology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    Clin Cancer Res 14:7741-50. 2008
    ..In this study, we investigate whether optimized mobilization of BMCs can further facilitate regeneration of radiation-damaged salivary glands...
  19. ncbi request reprint Optimum dose range for the amelioration of long term radiation-induced hyposalivation using prophylactic pilocarpine treatment
    Fred Ronald Burlage
    Department of Radiation Oncology, University of Groningen, The Netherlands
    Radiother Oncol 86:347-53. 2008
    ..To determine dose and time dependency of pilocarpine pre-treatment protection from late damage after unilateral irradiation of the rat parotid gland...
  20. ncbi request reprint Relation between radiation-induced whole lung functional loss and regional structural changes in partial irradiated rat lung
    Peter van Luijk
    Department of Radiation Oncology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    Int J Radiat Oncol Biol Phys 64:1495-502. 2006
    ..This study sought to determine the relation between the structural and functional changes in the irradiated rat lung at three different phases after irradiation...
  21. pmc Rescue of salivary gland function after stem cell transplantation in irradiated glands
    Isabelle M A Lombaert
    Section Radiation and Stress Cell Biology, Department of Cell Biology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    PLoS ONE 3:e2063. 2008
    ..Our approach is the first proof for the potential use of stem cell transplantation to functionally rescue salivary gland deficiency...
  22. doi request reprint HspB8 participates in protein quality control by a non-chaperone-like mechanism that requires eIF2{alpha} phosphorylation
    Serena Carra
    Department of Radiation and Stress Cell Biology, University Medical Center Groningen, A Deusinglaan 1, 9713 AV Groningen, The Netherlands
    J Biol Chem 284:5523-32. 2009
    ....
  23. ncbi request reprint Dysfunctional BRCA1 is only indirectly linked to multiple centrosomes
    Henderika M J Hut
    Department of Radiation and Stress Cell Biology, University of Groningen, UMCG, Ant Deusinglaan 1, 9713 AV Groningen, The Netherlands
    Oncogene 24:7619-23. 2005
    ..We present evidence that multiple centrosomes can arise in any cell when G2/M checkpoint fails and entrance into mitosis occurs in the presence of DNA damage...
  24. ncbi request reprint Radiation damage to the heart enhances early radiation-induced lung function loss
    Peter van Luijk
    Department of Radiation Oncology and Radiation, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    Cancer Res 65:6509-11. 2005
    ..This study for the first time shows that the response of an organ to irradiation does not necessarily depend on the dose distribution in that organ alone...
  25. ncbi request reprint Radiation and transforming growth factor-beta cooperate in transcriptional activation of the profibrotic plasminogen activator inhibitor-1 gene
    Jurre Hageman
    Department of Radiation and Stress Cell Biology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    Clin Cancer Res 11:5956-64. 2005
    ..This may play a role in patient-to-patient variations in susceptibility toward fibrosis after radiotherapy...
  26. pmc Drosophila phosphopantothenoylcysteine synthetase is required for tissue morphogenesis during oogenesis
    Floris Bosveld
    Department of Cell Biology, Section of Radiation and Stress Cell Biology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    BMC Res Notes 1:75. 2008
    ..Mutations in Drosophila dPPCS disrupt female fecundity and in this study we analyzed the female sterile phenotype of dPPCS mutants in detail...
  27. ncbi request reprint Comparison of intra-organellar chaperone capacity for dealing with stress-induced protein unfolding
    Jurre Hageman
    Department of Cell Biology, Section of Radiation and Stress Cell Biology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    J Biol Chem 282:34334-45. 2007
    ....
  28. doi request reprint The diverse members of the mammalian HSP70 machine show distinct chaperone-like activities
    Jurre Hageman
    Department of Cell Biology, Section of Radiation and Stress Cell Biology, University Medical Center Groningen, University of Groningen, Groningen 9700 AD, The Netherlands
    Biochem J 435:127-42. 2011
    ....
  29. doi request reprint HSPB7 is a SC35 speckle resident small heat shock protein
    Michel J Vos
    Department of Cell Biology, Section of Radiation and Stress Cell Biology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    Biochim Biophys Acta 1793:1343-53. 2009
    ..Some members also show a dynamic, stress-induced translocation to SC35 splicing speckles. If and how these features are interrelated and if they are shared by all members are yet unknown...
  30. ncbi request reprint Small heat shock proteins, protein degradation and protein aggregation diseases
    Michel J Vos
    Department of Cell Biology, Section for Radiation and Stress Cell Biology, University Medical Center Groningen, Groningen, The Netherlands
    Autophagy 7:101-3. 2011
    ..One member, HSPB7, has strong activities to prevent toxicity of polyglutamine-containing proteins in cells and Drosophila, and seems to act by assisting the loading of misfolded proteins or small protein aggregates into autophagosomes...
  31. ncbi request reprint Mobilization of bone marrow stem cells by granulocyte colony-stimulating factor ameliorates radiation-induced damage to salivary glands
    Isabelle M A Lombaert
    Section of Radiation and Stress Cell Biology, Department of Cell Biology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    Clin Cancer Res 12:1804-12. 2006
    ..Here, we assessed the potential of granulocyte colony-stimulating factor (G-CSF)-mobilized bone marrow-derived cells (BMC) to regenerate and functionally restore irradiated salivary glands used as a model for normal tissue damage...
  32. pmc ΔNp73 enhances promoter activity of TGF-β induced genes
    Maarten Niemantsverdriet
    Department of Cell Biology, Section Radiation and Stress Cell Biology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    PLoS ONE 7:e50815. 2012
    ..Given the role of TGF-β signaling in carcinogenesis, tumor invasion and metastasis via targets like PAI-1 and Col1a1, our data suggest a model on how this effect of ΔNp73 could be a contributing factor in cancer progression...
  33. doi request reprint Heat shock protein-inducing compounds as therapeutics to restore proteostasis in atrial fibrillation
    Femke Hoogstra-Berends
    Department of Clinical Pharmacology, University of Groningen, University Medical Center Groningen, 9713 AV Groningen, The Netherlands
    Trends Cardiovasc Med 22:62-8. 2012
    ..In this review, we discuss novel HSP-inducing compounds as emerging therapeutics for the primary and secondary prevention of AF...
  34. doi request reprint Heat shock proteins as molecular targets for intervention in atrial fibrillation
    Bianca J J M Brundel
    Department of Radiation and Stress Cell Biology, University of Groningen, University Medical Center Groningen, A Deusinglaan 1, 9713 AV Groningen, The Netherlands
    Cardiovasc Res 78:422-8. 2008
    ..Ultimately, this concept may offer an additional treatment strategy to delay progression towards chronic AF and/or improve the outcome of cardioversion...
  35. doi request reprint De novo CoA biosynthesis is required to maintain DNA integrity during development of the Drosophila nervous system
    Floris Bosveld
    Department of Cell Biology, Section of Radiation and Stress Cell Biology, University Medical Centre Groningen, University of Groningen, A Deusinglaan 1, 9713 AV Groningen, The Netherlands
    Hum Mol Genet 17:2058-69. 2008
    ..Surprisingly, our findings reveal a major role of this conserved pathway in maintaining DNA and cellular integrity, explaining how impaired CoA synthesis during CNS development can elicit a neurodegenerative phenotype...
  36. ncbi request reprint Differences in heat sensitivity between normal and acute myeloid leukemic stem cells: feasibility of hyperthermic purging of leukemic cells from autologous stem cell grafts
    Pieter K Wierenga
    Department of Radiation and Stress Cell Biology, University of Groningen, Groningen, The Netherlands
    Exp Hematol 31:421-7. 2003
    ..Therefore, in the present study the effects of hyperthermic treatment on the human normal and acute myeloid leukemic (AML) stem cell compartment were investigated...
  37. pmc Polarised asymmetric inheritance of accumulated protein damage in higher eukaryotes
    Maria A Rujano
    Department of Cell Biology, Section of Radiation and Stress Cell Biology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    PLoS Biol 4:e417. 2006
    ....
  38. ncbi request reprint Calpain inhibition prevents pacing-induced cellular remodeling in a HL-1 myocyte model for atrial fibrillation
    Bianca J J M Brundel
    Faculty Medical Science, Department of Radiation and Stress Cell Biology, Groningen Institute for Drug Exploration GUIDE, University of Groningen, A Deusinglaan 1, 9713 AV Groningen, The Netherlands
    Cardiovasc Res 62:521-8. 2004
    ..To study in more detail the mechanisms underlying myocyte remodeling and to develop strategies for drug-interference, we utilised a paced cell model for AF...
  39. pmc Overexpression of the cochaperone CHIP enhances Hsp70-dependent folding activity in mammalian cells
    Harm H Kampinga
    Department of Radiation and Stress Cell Biology, Faculty of Medical Sciences, University of Groningen, Groningen, The Netherlands
    Mol Cell Biol 23:4948-58. 2003
    ..Rather than resulting in inhibited refolding, CHIP increases the folding capacity of Hsp70 in eukaryotic cells...
  40. ncbi request reprint HSP27 protects AML cells against VP-16-induced apoptosis through modulation of p38 and c-Jun
    Hein Schepers
    Division of Hematology, Department of Medicine, University Medical Center Groningen, Groningen, The Netherlands
    Exp Hematol 33:660-70. 2005
    ..To investigate 1) the signal transduction pathways affected by heat shock protein 27 (HSP27) expression; and 2) the expression and regulation of HSP27 in acute myeloid leukemia (AML)...
  41. ncbi request reprint DNAJ proteins and protein aggregation diseases
    Vaishali Kakkar
    University of Groningen, University Medical Center Groningen, Department of Cell Biology, Groningen, The Netherlands
    Curr Top Med Chem 12:2479-90. 2012
    ..Finally, we will discuss the five known degenerative diseases that are linked to mutations in individual DNAJ members and what mechanism may underlie these DNAJ chaperonopathies...
  42. doi request reprint Alteration of protein folding and degradation in motor neuron diseases: Implications and protective functions of small heat shock proteins
    Serena Carra
    Department of Cell Biology, University Medical Center of Groningen, Antonius Deusinglaan 1, 9713 AV, Groningen, The Netherlands
    Prog Neurobiol 97:83-100. 2012
    ..How boosting of specific HSPBs may be a potential useful therapeutic approach in MNDs and how mutations in specific HSPBs can directly cause motor neuron degeneration is discussed...
  43. pmc Axonal inclusions in spinocerebellar ataxia type 3
    Kay Seidel
    Department of Pathology and Medical Biology, University Medical Centre Groningen, University of Groningen, 9713 RB Groningen, The Netherlands
    Acta Neuropathol 120:449-60. 2010
    ....
  44. doi request reprint Structural and functional diversities between members of the human HSPB, HSPH, HSPA, and DNAJ chaperone families
    Michel J Vos
    Department of Cell Biology, Section of Radiation and Stress Cell Biology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    Biochemistry 47:7001-11. 2008
    ..How substrate specificity and client processing is determined is far from being understood...
  45. pmc Hsp70 protects mitotic cells against heat-induced centrosome damage and division abnormalities
    Henderika M J Hut
    Section of Radiation and Stress Cell Biology, Department of Cell Biology, University Medical Center Groningen, University of Groningen, 9713 AV Groningen, The Netherlands
    Mol Biol Cell 16:3776-85. 2005
    ..Hsp70 is sufficient to protect against most division abnormalities, demonstrating the involvement of Hsp70 in a repair mechanism of heat-damaged mitotic centrosomes...
  46. doi request reprint A DNAJB chaperone subfamily with HDAC-dependent activities suppresses toxic protein aggregation
    Jurre Hageman
    Department of Cell Biology, Section of Radiation and Stress Cell Biology, University Medical Center Groningen and University of Groningen, 9700 RB Groningen, The Netherlands
    Mol Cell 37:355-69. 2010
    ..Combined, our data provide a functional link between HDACs and DNAJs in suppressing cytotoxic protein aggregation...
  47. ncbi request reprint Selective targeting of homologous DNA recombination repair by gemcitabine
    Floris M Wachters
    Department of Pulmonary Diseases, University Hospital Groningen, Groningen, The Netherlands
    Int J Radiat Oncol Biol Phys 57:553-62. 2003
    ..In the current study, we addressed the possibility that dFdC might affect homologous recombination (HR)-mediated DSB repair or base excision repair (BER)...
  48. ncbi request reprint Heat shock protein upregulation protects against pacing-induced myolysis in HL-1 atrial myocytes and in human atrial fibrillation
    Bianca J J M Brundel
    Department of Radiation and Stress Cell Biology, Groningen University Institute for Drug Exploration GUIDE, University Medical Center of Groningen, A Deusinglaan 1, 9713 AV Groningen, The Netherlands
    J Mol Cell Cardiol 41:555-62. 2006
    ..Pharmacological induction of Hsp, with drugs such as GGA, may represent a novel therapeutic approach in AF...
  49. doi request reprint Mutations in potassium channel kcnd3 cause spinocerebellar ataxia type 19
    Anna Duarri
    Department of Genetics, University of Groningen, University Medical Center Groningen, Groningen
    Ann Neurol 72:870-80. 2012
    ..To identify the causative gene for the neurodegenerative disorder spinocerebellar ataxia type 19 (SCA19) located on chromosomal region 1p21-q21...
  50. doi request reprint HSPBs: small proteins with big implications in human disease
    Harm H Kampinga
    Department of Cell Biology, University Medical Center Groningen, University of Groningen, Antonius Deusinglaan 1, 9713 AV, Groningen, The Netherlands
    Int J Biochem Cell Biol 44:1706-10. 2012
    ..This article is part of a Directed Issue entitled: Small HSPs in physiology and pathology...
  51. ncbi request reprint Protection of salivary function by concomitant pilocarpine during radiotherapy: a double-blind, randomized, placebo-controlled study
    Fred R Burlage
    Department of Radiation Oncology, University Medical Center Groningen, Groningen, The Netherlands
    Int J Radiat Oncol Biol Phys 70:14-22. 2008
    ..To investigate the effect of concomitant administration of pilocarpine during radiotherapy for head-and-neck squamous cell carcinoma (HNSCC) on postradiotherapy xerostomia...
  52. ncbi request reprint Molecular mechanisms of remodeling in human atrial fibrillation
    Bianca J J M Brundel
    Department of Radiation and Stress Cell Biology, University of Groningen, A Deusinglaan 1, P O Box 30 001, 9700 RB Groningen, The Netherlands
    Cardiovasc Res 54:315-24. 2002
    ..However, such early protection occurs at the expense of electrophysiological changes that promote the long-term maintenance of AF...
  53. doi request reprint A PCR amplification strategy for unrestricted generation of chimeric genes
    Michel J Vos
    Department of Cell Biology, Section of Radiation and Stress Cell Biology, University Medical Center Groningen, University of Groningen, Ant Deusinglaan 1, 9713 AV Groningen, The Netherlands
    Anal Biochem 380:338-40. 2008
    ..We have developed a cloning strategy to get around these disadvantages that is based on a single round of PCR amplification followed by antibiotic-resistant gene complementation...
  54. pmc Brain death induces renal expression of heme oxygenase-1 and heat shock protein 70
    Leon F A van Dullemen
    Department of Surgery, University of Groningen, Hanzeplein 1, Groningen, The Netherlands
    J Transl Med 11:22. 2013
    ..We studied the role of stress-inducible genes Heme Oxygenase-1 (HO-1), HSP27, HSP40, and HSP70 in the kidney following a 4 hour period of brain death...
  55. ncbi request reprint Pulmonary radiation injury: identification of risk factors associated with regional hypersensitivity
    Alena Novakova-Jiresova
    Department of Radiation and Stress Cell Biology, Faculty of Medical Sciences, University of Groningen, The Netherlands
    Cancer Res 65:3568-76. 2005
    ..As a repercussion, more severe acute and delayed toxicity should be expected after combined lung and heart irradiation. This should be considered in the process of radiotherapy treatment planning of thoracic malignancies...
  56. pmc Grp/DChk1 is required for G2-M checkpoint activation in Drosophila S2 cells, whereas Dmnk/DChk2 is dispensable
    Hilda I de Vries
    Department of Radiation and Stress Cell Biology, Division Cell Biology, Faculty of Medical Sciences, University of Groningen, Ant Deusinglaan 1, Building 3215, 9713 AV Groningen, The Netherlands
    J Cell Sci 118:1833-42. 2005
    ..We conclude that Grp/DChk1, and not Dmnk/DChk2, is the main effector kinase involved in G(2)/M checkpoint control in Drosophila cells...
  57. ncbi request reprint Transforming growth factor-beta plasma dynamics and post-irradiation lung injury in lung cancer patients
    Alena Novakova-Jiresova
    Department of Radiation and Stress Cell Biology, Faculty of Medical Sciences, University of Groningen, Ant Deusinglaan 1, bldg 3215, 9713 AV Groningen, The Netherlands
    Radiother Oncol 71:183-9. 2004
    ..To investigate the relevance of transforming growth factor-beta (TGF-beta) dynamics in plasma for identification of patients at low risk for developing pneumonitis as a complication of thoracic radiotherapy (RT)...
  58. ncbi request reprint Peripheral blood stem cells differ from bone marrow stem cells in cell cycle status, repopulating potential, and sensitivity toward hyperthermic purging in mice mobilized with cyclophosphamide and granulocyte colony-stimulating factor
    Pieter K Wierenga
    Department of Radiation and Stress Cell Biology, University of Groningen, 9713 AV Groningen, The Netherlands
    J Hematother Stem Cell Res 11:523-32. 2002
    ..These findings support the use of these mobilized PBSCs for autologous stem cell transplantation and strengthen the basis for using hyperthermia as a purging modality...
  59. pmc Kadota Fund International Forum 2004. Application of thermal stress for the improvement of health, 15-18 June 2004, Awaji Yumebutai International Conference Center, Awaji Island, Hyogo, Japan. Final report
    Tsutomu Sugahara
    Japan Health Foundation, Kyoto, Japan
    Int J Hyperthermia 24:123-40. 2008
  60. ncbi request reprint Induction of heat shock response protects the heart against atrial fibrillation
    Bianca J J M Brundel
    Department of Medicine and Research Center, Montreal Heart Institute, 5000 Belanger St E, Montreal, Quebec H1T 1C8, Canada
    Circ Res 99:1394-402. 2006
    ..These findings advance our understanding of the biochemical determinants of AF and suggest the possibility that HSP induction may be an interesting novel approach to preventing clinical AF...
  61. ncbi request reprint Significance of plasma transforming growth factor-beta levels in radiotherapy for non-small-cell lung cancer
    Katrien De Jaeger
    Department of Radiotherapy, The Netherlands Cancer Institute, Antoni van Leeuwenhoek Hospital, Amsterdam, The Netherlands
    Int J Radiat Oncol Biol Phys 58:1378-87. 2004
    ..The aim of this study was to evaluate prospectively the time course of TGF-beta1 levels in patients irradiated for NSCLC in relation to the development of RP and dose-volume parameters...
  62. ncbi request reprint Molecular chaperones enhance the degradation of expanded polyglutamine repeat androgen receptor in a cellular model of spinal and bulbar muscular atrophy
    Christine K Bailey
    Department of Biochemistry and Molecular Pharmacology, Thomas Jefferson University, 208 Bluemle Life Sciences Building, 233 S 10th Street, Philadelphia, PA 19107, USA
    Hum Mol Genet 11:515-23. 2002
    ..Molecular chaperone enhancement of protein degradation points to the modulation of molecular chaperones as a potential therapeutic target for polyglutamine diseases...
  63. ncbi request reprint Post-irradiation dietary vitamin E does not affect the development of radiation-induced lung damage in rats
    Erwin M Wiegman
    Department of Radiation Oncology, University Hospital Groningen, P O Box 30 001, 9700 RB Groningen, The Netherlands
    Radiother Oncol 72:67-70. 2004
    ..Neither breathing frequencies nor CT density measurements revealed differences between the groups. It is concluded that post-irradiation vitamin E does not influence radiation-induced fibrosis to the lung...
  64. pmc Distribution, phosphorylation, and activities of Hsp25 in heat-stressed H9c2 myoblasts: a functional link to cytoprotection
    Anton L Bryantsev
    Molecular and Cellular Cardiology Lab, Institute of Experimental Cardiology, Cardiology Research Centre, Moscow, Russia
    Cell Stress Chaperones 7:146-55. 2002
    ....
  65. pmc Regulation of stress-induced intracellular sorting and chaperone function of Hsp27 (HspB1) in mammalian cells
    Anton L Bryantsev
    Department of Electron Microscopy, Belozersky Institute of Physico Chemical Biology, Moscow State University, Moscow, 119992, Russia
    Biochem J 407:407-17. 2007
    ..We conclude that HspB1 contributes to an increased chaperone capacity of cells by binding unfolded proteins that are hereby kept competent for refolding by Hsp70 or that are sorted to nuclear granules if such refolding fails...