Cees Gm Kallenberg

Summary

Affiliation: University Hospital Groningen
Country: The Netherlands

Publications

  1. pmc Staphylococcus aureus and Wegener's granulomatosis
    Eliane R Popa
    Department of Clinical Immunology, University Hospital Groningen, Hanzeplein 1, 9713 GZ Groningen, The Netherlands
    Arthritis Res 4:77-9. 2002
  2. ncbi New treatments of ANCA-associated vasculitis
    C G Kallenberg
    Department of Clinical Immunology, University Hospital Groningen, The Netherlands
    Sarcoidosis Vasc Diffuse Lung Dis 17:125-9. 2000
  3. ncbi Vasculitis: clinical approach, pathophysiology and treatment
    C G Kallenberg
    Department of Clinical Immunology, University Hospital Groningen, The Netherlands
    Wien Klin Wochenschr 112:656-9. 2000
  4. ncbi New insights into the pathogenesis of antineutrophil cytoplasmic autoantibody-associated vasculitis
    Cees G M Kallenberg
    Department of Clinical Immunology, University Hospital Groningen, Hanzeplein 1, 9713 GZ Groningen, The Netherlands
    Autoimmun Rev 1:61-6. 2002
  5. ncbi Genetics of ANCA-associated vasculitides
    Cees G M Kallenberg
    Department of Clinical Immunology, University Hospital Groningen, The Netherlands
    Cleve Clin J Med 69:SII61-3. 2002
  6. ncbi The role of bacterial infections for the initiation and exacerbation of systemic vasculitis
    C G M Kallenberg
    Department of Clinical Immunology, University Hospital Groningen, The Netherlands
    Autoimmun Rev 3:S45-7. 2004
  7. ncbi What is new with anti-neutrophil cytoplasmic antibodies: diagnostic, pathogenetic and therapeutic implications
    C G Kallenberg
    Department of Clinical Immunology, University Hospital, Groningen, The Netherlands
    Curr Opin Nephrol Hypertens 8:307-15. 1999
  8. ncbi Why rheumatologists should be involved in the treatment of lupus nephritis
    Cees Gm Kallenberg
    Department of Rheumatology and Clinical Immunology, University Medical Center Groningen, University of Groningen, PO Box 30 001, 9700 RB Groningen, The Netherlands
    Nat Clin Pract Nephrol 4:60-1. 2008
  9. pmc High mobility group box 1 (HMGB1) and anti-HMGB1 antibodies and their relation to disease characteristics in systemic lupus erythematosus
    Deena A Abdulahad
    Department of Rheumatology and Clinical Immunology, University Medical Center Groningen, University of Groningen, PO Box 30 001, 9700 RB Groningen, The Netherlands
    Arthritis Res Ther 13:R71. 2011
  10. pmc Plasma levels of soluble interleukin 2 receptor, soluble CD30, interleukin 10 and B cell activator of the tumour necrosis factor family during follow-up in vasculitis associated with proteinase 3-antineutrophil cytoplasmic antibodies: associations with di
    J S F Sanders
    Department of Internal Medicine, Division of Clinical Immunology, University Medical Center Groningen, University of Groningen, Hanzeplein 1, 9700 GZ Groningen, The Netherlands
    Ann Rheum Dis 65:1484-9. 2006

Detail Information

Publications94

  1. pmc Staphylococcus aureus and Wegener's granulomatosis
    Eliane R Popa
    Department of Clinical Immunology, University Hospital Groningen, Hanzeplein 1, 9713 GZ Groningen, The Netherlands
    Arthritis Res 4:77-9. 2002
    ..Here we review both clinical and experimental data that either indicate or support a role for S. aureus in WG...
  2. ncbi New treatments of ANCA-associated vasculitis
    C G Kallenberg
    Department of Clinical Immunology, University Hospital Groningen, The Netherlands
    Sarcoidosis Vasc Diffuse Lung Dis 17:125-9. 2000
    ..Several of those new treatment modalities are now being tested in controlled studies by the European Vasculitis Study Group (EUVAS)...
  3. ncbi Vasculitis: clinical approach, pathophysiology and treatment
    C G Kallenberg
    Department of Clinical Immunology, University Hospital Groningen, The Netherlands
    Wien Klin Wochenschr 112:656-9. 2000
    ..Less toxic regimens as well as new treatment modalities based on insight into the pathophysiology of systemic vasculitides have been developed and are currently being tested in multicentre European studies...
  4. ncbi New insights into the pathogenesis of antineutrophil cytoplasmic autoantibody-associated vasculitis
    Cees G M Kallenberg
    Department of Clinical Immunology, University Hospital Groningen, Hanzeplein 1, 9713 GZ Groningen, The Netherlands
    Autoimmun Rev 1:61-6. 2002
    ..The ANCA-associated vasculitides are systemic autoimmune diseases in which the interplay of autoimmunity with environmental and genetic factors determines their clinical expression...
  5. ncbi Genetics of ANCA-associated vasculitides
    Cees G M Kallenberg
    Department of Clinical Immunology, University Hospital Groningen, The Netherlands
    Cleve Clin J Med 69:SII61-3. 2002
  6. ncbi The role of bacterial infections for the initiation and exacerbation of systemic vasculitis
    C G M Kallenberg
    Department of Clinical Immunology, University Hospital Groningen, The Netherlands
    Autoimmun Rev 3:S45-7. 2004
  7. ncbi What is new with anti-neutrophil cytoplasmic antibodies: diagnostic, pathogenetic and therapeutic implications
    C G Kallenberg
    Department of Clinical Immunology, University Hospital, Groningen, The Netherlands
    Curr Opin Nephrol Hypertens 8:307-15. 1999
    ..New treatment regimens, based on new pathogenetic concepts, are currently being tested...
  8. ncbi Why rheumatologists should be involved in the treatment of lupus nephritis
    Cees Gm Kallenberg
    Department of Rheumatology and Clinical Immunology, University Medical Center Groningen, University of Groningen, PO Box 30 001, 9700 RB Groningen, The Netherlands
    Nat Clin Pract Nephrol 4:60-1. 2008
  9. pmc High mobility group box 1 (HMGB1) and anti-HMGB1 antibodies and their relation to disease characteristics in systemic lupus erythematosus
    Deena A Abdulahad
    Department of Rheumatology and Clinical Immunology, University Medical Center Groningen, University of Groningen, PO Box 30 001, 9700 RB Groningen, The Netherlands
    Arthritis Res Ther 13:R71. 2011
    ..In this study we determined levels of HMGB1 and anti-HMGB1 in SLE patients in comparison to healthy controls (HC) and analysed their relation with disease activity...
  10. pmc Plasma levels of soluble interleukin 2 receptor, soluble CD30, interleukin 10 and B cell activator of the tumour necrosis factor family during follow-up in vasculitis associated with proteinase 3-antineutrophil cytoplasmic antibodies: associations with di
    J S F Sanders
    Department of Internal Medicine, Division of Clinical Immunology, University Medical Center Groningen, University of Groningen, Hanzeplein 1, 9700 GZ Groningen, The Netherlands
    Ann Rheum Dis 65:1484-9. 2006
    ....
  11. ncbi Risk factors for relapse in anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis: tools for treatment decisions?
    J S F Sanders
    Department of Clinical Immunology, University Hospital Groningen, The Netherlands
    Clin Exp Rheumatol 22:S94-101. 2004
    ..We review here the risk factors for relapse in ANCA-associated vasculitis, their potential pathogenic implications, and their possible role in preventive strategies and adaptations of current treatment policies...
  12. pmc Reduced uptake of apoptotic cells by macrophages in systemic lupus erythematosus: correlates with decreased serum levels of complement
    M Bijl
    Department of Internal Medicine, Division of Clinical Immunology, University Hospital, The Netherlands
    Ann Rheum Dis 65:57-63. 2006
    ..Decrease of phagocytosis of apoptotic cells occurs in systemic lupus erythematosus (SLE). Factors underlying this decrease are, presently, unknown...
  13. pmc Mycophenolate mofetil prevents a clinical relapse in patients with systemic lupus erythematosus at risk
    M Bijl
    Department of Clinical Immunology, University Hospital, Groningen, The Netherlands
    Ann Rheum Dis 62:534-9. 2003
    ....
  14. pmc Serum amyloid P component levels are not decreased in patients with systemic lupus erythematosus and do not rise during an acute phase reaction
    M Bijl
    Department of Internal Medicine, Division of Clinical Immunology, University Hospital, PO Box 30 001, 9700 RB Groningen, Netherlands
    Ann Rheum Dis 63:831-5. 2004
    ..Serum amyloid P component (SAP) and acute phase proteins like C-reactive protein contribute to the clearance of apoptotic cells. This response is diminished in systemic lupus erythematosus (SLE)...
  15. pmc Increase in IL-21 producing T-cells in patients with systemic lupus erythematosus
    Sebastian Dolff
    Department of Rheumatology and Clinical Immunology, University Medical Center Groningen, University of Groningen, Hanzeplein 1, 9700 RB Groningen, The Netherlands
    Arthritis Res Ther 13:R157. 2011
    ..The novel cytokine interleukin-21 (IL-21) is suggested to be crucial for triggering T-cell responses towards IL-17 producing cells. Thus, we aimed to investigate the ability of T-cells to produce IL-21 and IL-17 in SLE patients...
  16. ncbi Quantitation of autoantibodies in systemic autoimmune diseases: clinically useful?
    C G M Kallenberg
    Department of Internal Medicine, University Medical Center Groningen, The Netherlands
    Lupus 15:397-402. 2006
    ..Consequently, treatment based on changes in levels of the respective autoantibodies only seems at present not justified, in view of the toxicity of currently available immunosuppressive regimens...
  17. ncbi Prediction of relapses in PR3-ANCA-associated vasculitis by assessing responses of ANCA titres to treatment
    J S F Sanders
    Division of Clinical Immunology, University Medical Center Groningen, University of Groningen, Hanzeplein 1, 9700 GZ Groningen, The Netherlands
    Rheumatology (Oxford) 45:724-9. 2006
    ....
  18. ncbi Levels of complement in sera from inactive SLE patients, although decreased, do not influence in vitro uptake of apoptotic cells
    M E Grevink
    Department of Internal Medicine, Division of Clinical Immunology, University Hospital, PO Box 30 001, 9700 RB Groningen, The Netherlands
    J Autoimmun 24:329-36. 2005
    ..Complement factors facilitate the clearance of apoptotic cells and, when decreased, might result in an increased amount of apoptotic cells found in SLE patients...
  19. doi Wegener's granulomatosis patients show an adequate antibody response to influenza vaccination
    A Holvast
    Department of Rheumatology and Clinical Immunology, University Medical Center Groningen, University of Groningen, The Netherlands
    Ann Rheum Dis 68:873-8. 2009
    ..Therefore, influenza vaccination should be considered in WG patients. This study was performed to assess the immunogenicity of influenza vaccination in WG patients...
  20. ncbi Increased frequency of circulating IL-21 producing Th-cells in patients with granulomatosis with polyangiitis (GPA)
    Wayel H Abdulahad
    Department of Rheumatology and Clinical Immunology, University of Groningen, University Medical Center Groningen, Hanzeplein 1, 9713 GZ, Groningen, The Netherlands
    Arthritis Res Ther 15:R70. 2013
    ..The present study aimed to explore a possible role for IL-21 producing Th-cells in the immunopathogenesis of granulomatosis with polyangiitis (GPA)...
  21. pmc Baseline predictors of response and discontinuation of tumor necrosis factor-alpha blocking therapy in ankylosing spondylitis: a prospective longitudinal observational cohort study
    Suzanne Arends
    Rheumatology and Clinical Immunology, University Medical Center Groningen, University of Groningen, P O Box 30 001, 9700 RB Groningen, The Netherlands
    Arthritis Res Ther 13:R94. 2011
    ..The aim of the present study was to identify baseline predictors of response and discontinuation of TNF-α blocking therapy in AS patients in daily clinical practice...
  22. pmc Advanced glycation endproducts are increased in rheumatoid arthritis patients with controlled disease
    Lodewijk de Groot
    Department of Rheumatology and Clinical Immunology, University Medical Centre, University of Groningen, Groningen, The Netherlands
    Arthritis Res Ther 13:R205. 2011
    ....
  23. pmc Safety and efficacy of influenza vaccination in systemic lupus erythematosus patients with quiescent disease
    A Holvast
    Department of Clinical Immunology, University Medical Center Groningen, University of Groningen, PO Box 30 001, 9700 RB Groningen, Netherlands
    Ann Rheum Dis 65:913-8. 2006
    ..to assess the safety and efficacy of influenza vaccination in patients with systemic lupus erythematosus (SLE), and to evaluate the influence of immunosuppressive drugs on the immune response...
  24. doi Coexpression of CD177 and membrane proteinase 3 on neutrophils in antineutrophil cytoplasmic autoantibody-associated systemic vasculitis: anti-proteinase 3-mediated neutrophil activation is independent of the role of CD177-expressing neutrophils
    N Hu
    Department of Rheumatology and Clinical Immunology, University Medical Center Groningen, Groningen, The Netherlands
    Arthritis Rheum 60:1548-57. 2009
    ....
  25. doi An extensive screen of the HLA region reveals an independent association of HLA class I and class II with susceptibility for systemic lupus erythematosus
    H A Martens
    Department of Rheumatology and Clinical Immunology, University Medical Centre Groningen, University of Groningen, Groningen, The Netherlands
    Scand J Rheumatol 38:256-62. 2009
    ..In this study, we analysed the involvement of the HLA region in susceptibility for SLE in a stable founder, Caucasian population of SLE patients...
  26. ncbi Antineutrophil cytoplasmic autoantibody-associated small-vessel vasculitis
    Cees Gm Kallenberg
    Department of Rheumatology and Clinical Immunology, University Medical Center Groningen, University of Groningen, The Netherlands
    Curr Opin Rheumatol 19:17-24. 2007
    ..This review focuses on recent advances in the diagnosis, pathogenesis and treatment of antineutrophil cytoplasmic autoantibody-associated small-vessel vasculitis...
  27. pmc B cell epitope specificity in ANCA-associated vasculitis: does it matter?
    Y M van der Geld
    Department of Clinical Immunology, University Hospital Groningen, Groningen, The Netherlands
    Clin Exp Immunol 137:451-9. 2004
    ..Elucidating a disease-inducing epitope bound by ANCA may lead to the development of epitope-specific therapeutic strategies...
  28. ncbi Type I interferons are involved in the development of ultraviolet B-induced inflammatory skin lesions in systemic lupus erythaematosus patients
    E Reefman
    Departments of Rheumatology and Clinical Immunology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    Ann Rheum Dis 67:11-18. 2008
    ..To investigate the involvement of type I interferons and endothelial cell adhesion molecules in the development of ultraviolet B (UVB)-induced systemic lupus erythaematosus (SLE) skin lesions...
  29. ncbi Pathogenesis of PR3-ANCA associated vasculitis
    C G M Kallenberg
    Department of Rheumatology and Clinical Immunology, University Medical Center Groningen, University of Groningen, P O Box 30 001, 9700 RB Groningen, The Netherlands
    J Autoimmun 30:29-36. 2008
    ..These factors, together, may explain, at least in part, differences in clinical expression between MPO-ANCA and PR3-ANCA associated vasculitis...
  30. pmc Interference of PR3-ANCA with the enzymatic activity of PR3: differences in patients during active disease or remission of Wegener's granulomatosis
    Y M van der Geld
    Department of Internal Medicine, University Hospital Groningen, The Netherlands
    Clin Exp Immunol 129:562-70. 2002
    ..This may indicate that during active disease the ANCA titre is increased, but the number of active ANCA molecules that recognize the enzyme-inhibiting epitopes is not increased...
  31. ncbi The Th1 and Th2 paradigm in ANCA-associated vasculitis
    J S F Sanders
    Department of Clinical Immunology, University Hospital, Groningen, The Netherlands
    Kidney Blood Press Res 26:215-20. 2003
    ..Further studies elucidating the true nature of the polarization towards Th1 or Th2 in ANCA-associated vasculitis are clearly needed...
  32. doi Regulators of B-cell activity in SLE: a better target for treatment than B-cell depletion?
    S Dolff
    Department of Rheumatology, University Medical Center Groningen, Groningen, The Netherlands
    Lupus 18:575-80. 2009
    ..More insight into B-cell regulation in SLE, and particularly in regulatory B cells, could lead to novel therapeutic strategies...
  33. doi Analysis of C1q polymorphisms suggests association with systemic lupus erythematosus, serum C1q and CH50 levels and disease severity
    H A Martens
    Department of Rheumatology and Clinical Immunology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    Ann Rheum Dis 68:715-20. 2009
    ..Polymorphisms of the C1qA gene are associated with low serum C1q levels in patients with cutaneous LE, but C1q polymorphisms have not been studied in patients with systemic lupus...
  34. ncbi IgG subclass distribution of autoantibodies differs between renal and extra-renal relapses in patients with systemic lupus erythematosus
    M Bijl
    Department of Clinical Immunology, University Hospital, 9700 RB Groningen, The Netherlands
    Rheumatology (Oxford) 41:62-7. 2002
    ..IgG subclasses of autoantibodies differ in their potential to induce an inflammatory response as they interact differentially with complement and Fcgamma receptors...
  35. ncbi Staphylococcal toxic-shock-syndrome-toxin-1 as a risk factor for disease relapse in Wegener's granulomatosis
    E R Popa
    Department of Medical Biology, University of Groningen, Hanzeplein 1, 9713 GZ Groningen, The Netherlands
    Rheumatology (Oxford) 46:1029-33. 2007
    ..We hypothesized that staphylococcal superantigens (SAg) are a determinant of S. aureus-related risk for disease relapse in WG...
  36. pmc Progression of salivary gland dysfunction in patients with Sjogren's syndrome
    J Pijpe
    University Medical Center Groningen, University of Groningen, PO Box 30001, 9700 RB Groningen, The Netherlands
    Ann Rheum Dis 66:107-12. 2007
    ..Salivary gland dysfunction is one of the key manifestations of Sjögren's syndrome...
  37. ncbi Skin sensitivity to UVB irradiation in systemic lupus erythematosus is not related to the level of apoptosis induction in keratinocytes
    E Reefman
    Department of Rheumatology and Clinical Immunology, University Medical Center Groningen, 9700 RB Groningen, The Netherlands
    Rheumatology (Oxford) 45:538-44. 2006
    ..As sunlight exposure is one of the factors that can trigger disease activity, we hypothesized that UV light may induce increased numbers of apoptotic cells in SLE...
  38. pmc Staphylococcal superantigens and T cell expansions in Wegener's granulomatosis
    E R Popa
    Department of Clinical Immunology, University Hospital, Groningen, The Netherlands
    Clin Exp Immunol 132:496-504. 2003
    ..We conclude that in WG S. aureus effects its supposed pathogenic function by a mechanism other than superantigenic T cell activation...
  39. pmc Sialometry and sialochemistry: a non-invasive approach for diagnosing Sjögren's syndrome
    W W I Kalk
    Department of Oral and Maxillofacial Surgery, University Hospital Groningen, PO Box 30 001, 9700 RB Groningen, The Netherlands
    Ann Rheum Dis 61:137-44. 2002
    ..Because univocal salivary reference values are lacking, it is currently rather difficult to use sialometry and sialochemistry for diagnosing SS unless major changes have occurred in salivary secretion and composition...
  40. ncbi Familial occurrence of autoimmune diseases and autoantibodies in a Caucasian population of patients with systemic lupus erythematosus
    S Corporaal
    University Hospital, Groningen, The Netherlands
    Clin Rheumatol 21:108-13. 2002
    ..These findings support the genome-wide screening of SLE patients to unravel factors responsible for genetic susceptibility to SLE...
  41. ncbi The formation of autoantibodies and antibodies to TNF-α blocking agents in relation to clinical response in patients with ankylosing spondylitis
    S Arends
    Rheumatology and Clinical Immunology, University Medical Center Groningen, Groningen, The Netherlands
    Clin Exp Rheumatol 28:661-8. 2010
    ....
  42. ncbi Rituximab treatment in patients with primary Sjögren's syndrome: an open-label phase II study
    J Pijpe
    Department of Oral and Maxillofacial Surgery, University Medical Center Groningen, Groningen, The Netherlands
    Arthritis Rheum 52:2740-50. 2005
    ....
  43. ncbi Hypoxia inducible factor-1-alpha (HIF-1alpha) is related to both angiogenesis and inflammation in rheumatoid arthritis
    E Brouwer
    Department of Rheumatology and Clinical Immunology, University Medical Centre Groningen, Hanzeplein 1, 9713 GZ Groningen, The Netherlands
    Clin Exp Rheumatol 27:945-51. 2009
    ....
  44. ncbi In vitro cytokine production and proliferation of T cells from patients with anti-proteinase 3- and antimyeloperoxidase-associated vasculitis, in response to proteinase 3 and myeloperoxidase
    E R Popa
    Department of Clinical Immunology, University Hospital Groningen, Groningen, The Netherlands
    Arthritis Rheum 46:1894-904. 2002
    ....
  45. ncbi New advances in the pathogenesis of ANCA-associated vasculitides
    M Chen
    Department of Rheumatology and Clinical Immunology, University Medical Center Groningen, University of Groningen, The Netherlands
    Clin Exp Rheumatol 27:S108-14. 2009
    ..Together, clinical, in vitro and in vivo data support a pathogenic role for ANCA in AAV, although this role is more evident for myeloperoxidase-ANCA than for PR3-ANCA. The role of anti- LAMP-2 requires further studies...
  46. pmc Standardised assessment of membrane proteinase 3 expression. Analysis in ANCA-associated vasculitis and controls
    Andre P van Rossum
    Department of Rheumatology and Clinical Immunology, Groningen University Medical Centre, University of Groningen, The Netherlands
    Ann Rheum Dis 66:1350-5. 2007
    ..Using neutrophils before and after priming with TNFalpha, we assessed percentages of mPR3(+) neutrophils in patients with AAV and in disease and healthy controls...
  47. ncbi Opsonization of late apoptotic cells by systemic lupus erythematosus autoantibodies inhibits their uptake via an Fcgamma receptor-dependent mechanism
    Esther Reefman
    University Medical Center Groningen, and University of Groningen, Groningen, The Netherlands
    Arthritis Rheum 56:3399-411. 2007
    ..The aim of this study was to investigate whether the binding of SLE autoantibodies to apoptotic cells influences the phagocytosis of these cells by macrophages...
  48. pmc Is disturbed clearance of apoptotic keratinocytes responsible for UVB-induced inflammatory skin lesions in systemic lupus erythematosus?
    Esther Reefman
    Department of Rheumatology and Clinical Immunology, University Medical Center Groningen, University of Groningen, PO Box 30, 001, 9700 RB Groningen, The Netherlands
    Arthritis Res Ther 8:R156. 2006
    ....
  49. ncbi Autoantibodies against protective molecules--C1q, C-reactive protein, serum amyloid P, mannose-binding lectin, and apolipoprotein A1: prevalence in systemic lupus erythematosus
    Yehuda Shoenfeld
    Center for Autoimmune Diseases and Department of Medicine B, Chaim Sheba Medical Center, Tel Hashomer, Israel
    Ann N Y Acad Sci 1108:227-39. 2007
    ..These autoantibodies may play a pathogenic role in the development or perpetuation of autoimmunity in SLE...
  50. ncbi Inflammatory clearance of apoptotic cells after UVB challenge
    Marc Bijl
    Division of Clinical Immunology, Department of Internal Medicine, University Medical Center Groningen, University of Groningen Groningen The Netherlands
    Autoimmunity 40:244-8. 2007
    ..In this review, we will focus on apoptotic cells, their elimination, and the consequences of a disturbed elimination of apoptotic cells on the development of UVB induced inflammatory skin lesions...
  51. ncbi Urinary matrix metalloproteinases reflect renal damage in anti-neutrophil cytoplasm autoantibody-associated vasculitis
    Jan Stephan F Sanders
    Univ Medical Center Groningen, Dept of Clinical Immunology, Hanzeplein 1, 9700 GZ Groningen, The Netherlands
    Am J Physiol Renal Physiol 293:F1927-34. 2007
    ..However, urinary MMP-2 activity and TIMP-1 levels reflect tubulointerstitial damage and correlate negatively with creatinine clearance at biopsy...
  52. ncbi Human anti-neutrophil cytoplasm autoantibodies to proteinase 3 (PR3-ANCA) bind to neutrophils
    Andre P van Rossum
    Department of Rheumatology and Clinical Immunology, Groningen University Medical Centre, Groningen, The Netherlands
    Kidney Int 68:537-41. 2005
    ..Here we present evidence that human PR3-ANCA do specifically bind to PMN that express PR3 on their membrane...
  53. ncbi Renal expression of matrix metalloproteinases in human ANCA-associated glomerulonephritis
    Jan Stephan F Sanders
    Department of Internal Medicine, Division of Clinical Immunology, University Hospital Groningen, The Netherlands
    Nephrol Dial Transplant 19:1412-9. 2004
    ....
  54. ncbi Constitutive membrane expression of proteinase 3 (PR3) and neutrophil activation by anti-PR3 antibodies
    Andre P van Rossum
    Department of Internal Medicine, University Hospital Groningen, Hanzeplein 1, 9713 GZ Groningen, The Netherlands
    J Leukoc Biol 76:1162-70. 2004
    ..These data may be relevant in view of the observed relation between membrane expression of PR3 on nonprimed neutrophils of patients with WG and their susceptibility for relapses...
  55. ncbi Molecular genetic analyses of human NKG2C (KLRC2) gene deletion
    Risa Miyashita
    Department of Human Genetics, Graduate School of Medicine, University of Tokyo, Tokyo 113 0033, Japan
    Int Immunol 16:163-8. 2004
    ..These results indicated that NKG2C deletion is commonly present in Japanese and Dutch, suggesting that NKG2C is not essential for survival and reproduction, and is not associated with rheumatic diseases...
  56. ncbi Serum amyloid P component binds to late apoptotic cells and mediates their uptake by monocyte-derived macrophages
    Marc Bijl
    Department of Internal Medicine, University Hospital, Groningen, The Netherlands
    Arthritis Rheum 48:248-54. 2003
    ....
  57. ncbi The prototypic tissue pentraxin PTX3, in contrast to the short pentraxin serum amyloid P, inhibits phagocytosis of late apoptotic neutrophils by macrophages
    Andre P van Rossum
    University Hospital Groningen, Groningen, The Netherlands
    Arthritis Rheum 50:2667-74. 2004
    ..We undertook this study to test our hypothesis that PTX3 inhibits phagocytosis of late apoptotic PMNs by macrophages, thereby leading to their accumulation in the vessel wall...
  58. ncbi Ultraviolet light and cutaneous lupus
    Marc Bijl
    Department of Internal Medicine, Division of Clinical Immunology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    Lupus 15:724-7. 2006
    ..We review the role of apoptotic cells and autoantibodies in the pathogenesis of UVB induced skin lesions...
  59. ncbi Fcgamma receptor gene polymorphisms in Japanese patients with systemic lupus erythematosus: contribution of FCGR2B to genetic susceptibility
    Chieko Kyogoku
    University of Tokyo, Tokyo, Japan
    Arthritis Rheum 46:1242-54. 2002
    ....
  60. ncbi Role of the Fcgamma receptor IIA polymorphism in the antiphospholipid syndrome: an international meta-analysis
    Fotini B Karassa
    University of Ioannina School of Medicine, Ioannina, Greece
    Arthritis Rheum 48:1930-8. 2003
    ..To assess the impact of the FcgammaRIIA-R/H131 polymorphism on the risk for antiphospholipid syndrome (APS), both primary and secondary to systemic lupus erythematosus (SLE)...
  61. doi Autoantibodies vex the vasculature
    Cees G M Kallenberg
    Nat Med 14:1018-9. 2008
  62. ncbi Activation, apoptosis, and clearance of neutrophils in Wegener's granulomatosis
    Andre P van Rossum
    Department of Internal Medicine, University Medical Center Groningen, Hanzeplein 1, 9713 GZ Groningen, The Netherlands
    Ann N Y Acad Sci 1051:1-11. 2005
    ..All together, alive neutrophils as well as apoptotic neutrophils play a key role in different inflammatory phenomena seen in patients suffering from WG...
  63. ncbi Patients' perceptions of the effects of systemic lupus erythematosus on health, function, income, and interpersonal relationships: a comparison with Wegener's granulomatosis
    Maarten M Boomsma
    Clinical Immunology, University Hospital Groningen, Groningen, The Netherlands
    Arthritis Rheum 47:196-201. 2002
    ..To describe the patients' perceptions of the effects of systemic lupus erythematosus (SLE) and Wegener's granulomatosis (WG) on health, function, income, and interpersonal relationships...
  64. ncbi Image analysis: a novel approach for the quantification of antineutrophil cytoplasmic antibody levels in patients with Wegener's granulomatosis
    Maarten M Boomsma
    Department of Internal Medicine, Division of Clinical Immunology, University Hospital Groningen, Hanzeplein 1, 9713 GZ Groningen, The Netherlands
    J Immunol Methods 274:27-35. 2003
    ..No major differences were observed between image analysis and the other techniques in their capacity to predict relapses of disease activity...
  65. doi The last classification of vasculitis
    Cees G M Kallenberg
    Department of Rheumatology and Clinical Immunology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    Clin Rev Allergy Immunol 35:5-10. 2008
    ..The use of this algorithm together with the definitions for the large vessel vasculitides may result in a more unifying approach to the classification of the primary systemic vasculitides...
  66. ncbi Evaluation of capture ELISA for detection of antineutrophil cytoplasmic antibodies directed against proteinase 3 in Wegener's granulomatosis: first results from a multicentre study
    Elena Csernok
    Department of Rheumatology, University of Schleswig Holstein Campus Lübeck and Rheumaklinik Bad Bramstedt, Germany
    Rheumatology (Oxford) 43:174-80. 2004
    ..To evaluate the performance characteristics of direct and capture ELISA for the detection of PR3-ANCA in Wegener's granulomatosis (WG) in international ANCA reference laboratories...
  67. ncbi Dying neutrophils in ANCA-associated vasculitis: good or bad guys?
    Cees G M Kallenberg
    Kidney Int 61:758-9. 2002
  68. doi Skewed distribution of Th17 lymphocytes in patients with Wegener's granulomatosis in remission
    Wayel H Abdulahad
    Department of Rheumatology and Clinical Immunology, University Medical Center Groningen, Groningen, The Netherlands
    Arthritis Rheum 58:2196-205. 2008
    ..We undertook this study to assess the distribution of Th1/Th2/Th17 cells and to investigate the presence of Th17 cells specific for the WG autoantigen proteinase 3 (PR3) in WG...
  69. ncbi Fcgamma receptors in the initiation and progression of systemic lupus erythematosus
    Esther Reefman
    Department of Internal Medicine, Division of Clinical Immunology, University Hospital, Groningen, The Netherlands
    Immunol Cell Biol 81:382-9. 2003
    ..This review focuses on the role of Fcgamma receptors in the initiation of autoantibody production, inflammatory handling of immune complexes, and disease development in systemic lupus erythematosus...
  70. ncbi Current status of outcome measures in vasculitis: focus on Wegener's granulomatosis and microscopic polyangiitis. Report from OMERACT 7
    Peter A Merkel
    Boston University School of Medicine, Boston, MA 02118, USA
    J Rheumatol 32:2488-95. 2005
    ....
  71. ncbi The R-H polymorphism of FCgamma receptor IIa as a risk factor for systemic lupus erythematosus is independent of single-nucleotide polymorphisms in the interleukin-10 gene promoter
    Hilde M Dijstelbloem
    Arthritis Rheum 46:1125-6. 2002
  72. ncbi Neutrophil membrane expression of proteinase 3 (PR3) is related to relapse in PR3-ANCA-associated vasculitis
    Agnieszka A Rarok
    Department of Internal Medicine, University Hospital Groningen, The Netherlands
    J Am Soc Nephrol 13:2232-8. 2002
    ..These data support the hypothesis that PR3 expression on the membrane of neutrophils plays a role in the pathophysiology of PR3-ANCA associated vasculitis...
  73. ncbi Parotid sialography for diagnosing Sjögren syndrome
    Wouter W I Kalk
    Department of Oral and Maxillofacial Surgery, University Hospital Groningen, Hanzeplain 1, 9713 GZ Groningen, The Netherlands
    Oral Surg Oral Med Oral Pathol Oral Radiol Endod 94:131-7. 2002
    ..In this study, the clinical value of sialography as a diagnostic tool in SS was explored by assessing its diagnostic accuracy, observer bias, and staging potential...
  74. ncbi Increased seroreactivity in tic disorder patients to a 60 kDa protein band from a neuronal cell line
    Pieter J Hoekstra
    Child and Adolescent Psychiatry Center Groningen, Hanzeplein 1, 9713 GZ Groningen, The Netherlands
    J Neuroimmunol 141:118-24. 2003
    ..0%) and healthy controls (41.9%). Sequence analysis of the 60 kDa protein band identified this as a ubiquitous heat shock protein. However, the involvement of other autoantigens with a molecular weight of 60 kDa cannot be excluded...
  75. ncbi Neutrophil-activating potential of antineutrophil cytoplasm autoantibodies
    Agnieszka A Rarok
    Department of Internal Medicine, University Hospital Groningen, The Netherlands
    J Leukoc Biol 74:3-15. 2003
    ..We summarize current knowledge on the signal-transduction pathways initiated by ANCA and on the factors determining susceptibility of neutrophils to activation by these autoantibodies...
  76. ncbi The future of damage assessment in vasculitis
    Philip Seo
    Division of Rheumatology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    J Rheumatol 34:1357-71. 2007
    ..This initiative is part of a larger international effort to create a unified approach to disease assessment for the primary systemic vasculitides...
  77. ncbi Inhibition of proinflammatory genes in anti-GBM glomerulonephritis by targeted dexamethasone-loaded AbEsel liposomes
    Sigridur A Asgeirsdottir
    Department of Pathology and Laboratory Medicine, Medical Biology Section, Hanzeplein 1, 9713 GZ Groningen, The Netherlands
    Am J Physiol Renal Physiol 294:F554-61. 2008
    ..This study demonstrates the potential of vascular bed-specific drug delivery aimed at disease-induced epitopes on the microvascular endothelial cells as a therapeutic strategy for glomerulonephritis...
  78. ncbi Diversity of PR3-ANCA epitope specificity in Wegener's granulomatosis. Analysis using the biosensor technology
    Agnieszka A Rarok
    Department of Internal Medicine, University Hospital Groningen, Groningen, The Netherlands
    J Clin Immunol 23:460-8. 2003
    ..These changes in epitope specificity of PR3-ANCA may be responsible for the differences in functional properties of these autoantibodies between various stages of the disease...
  79. ncbi Do apoptotic cells accumulate in the epidermis of patients with cutaneous lupus erythematosus after ultraviolet irradiation? Comment on the article by Kuhn et al
    Esther Reefman
    Arthritis Rheum 54:3373-4. 2006
  80. ncbi Apoptosis in human skin: role in pathogenesis of various diseases and relevance for therapy
    Esther Reefman
    Departments of Rheumatology and Clinical Immunology, University Hospital Groningen, P O Box 30 001, 9700 RB Groningen, The Netherlands
    Ann N Y Acad Sci 1051:52-63. 2005
    ..This paper will review the different forms of cell death in the skin and discuss the role of apoptosis in diseases like skin cancer, psoriasis, and systemic lupus erythematosus...
  81. ncbi Mechanisms of Disease: pathogenesis and treatment of ANCA-associated vasculitides
    Cees G M Kallenberg
    Department of Rheumatology and Clinical Immunology, University Medical Center, University of Groningen, 9700 RB Groningen, The Netherlands
    Nat Clin Pract Rheumatol 2:661-70. 2006
    ..Several controlled trials have led to an evidence-based approach for the treatment of ANCA-associated vasculitis, and further studies, based on new insights into pathogenesis, are in progress...
  82. ncbi Urinary monocyte chemoattractant protein-1 (MCP-1) is a marker of active renal vasculitis
    Frederick W K Tam
    Renal Section, Division of Medicine, Faculty of Medicine, Imperial College London, Hammersmith Hospital, Du Cane Road, London W12 0NN, UK
    Nephrol Dial Transplant 19:2761-8. 2004
    ..The aim of this study was to investigate whether urinary levels of chemokines, monocyte chemoattractant protein-1 (MCP-1) and fractalkine, were useful tools for non-invasive assessment of renal vasculitis...
  83. ncbi Use of mycophenolic acid in non-transplant renal diseases
    Patricia M Stassen
    Department of Nephrology, University Medical Center Groningen, PO Box 30001, 9700 RB Groningen, The Netherlands
    Nephrol Dial Transplant 22:1013-9. 2007
  84. pmc Association of poly(ADP-ribose) polymerase 1 and a novel candidate locus, LOC127086, with systemic lupus erythematosus
    Henk A Martens
    Ann Rheum Dis 66:424-5. 2007
  85. ncbi Abundance of the long pentraxin PTX3 at sites of leukocytoclastic lesions in patients with small-vessel vasculitis
    Andre P van Rossum
    University Medical Centre Groningen, Groningen, The Netherlands
    Arthritis Rheum 54:986-91. 2006
    ..We therefore hypothesized that PTX3 accumulates at sites of leukocytoclastic vasculitis and, as such, is a key factor for the induction of leukocytoclasis...
  86. ncbi Influenza vaccination in systemic lupus erythematosus: safe and protective?
    Bert Holvast
    Department of Clinical Immunology, University Medical Center Groningen, University of Groningen, The Netherlands
    Autoimmun Rev 6:300-5. 2007
    ..Because of the decreased immunogenicity of the current influenza vaccine in SLE, new influenza vaccination strategies should be explored to improve vaccination efficacy...
  87. ncbi Smoking and increased apoptosis in patients with systemic lupus erythematosus: comment on the article by Costenbader et al
    Marc Bijl
    Arthritis Rheum 50:3733; author reply 3733. 2004
  88. ncbi Prognostic value of renal hemodynamic characteristics in patients with proliferative lupus nephritis
    Henk A Martens
    Department of Rheumatology and Clinical Immunology, University Medical Center Groningen UMCG, University of Groningen, Groningen, The Netherlands
    Kidney Blood Press Res 30:175-81. 2007
    ..In this study, we evaluate the prognostic value of renal hemodynamic function tests on the renal outcome in patients with proliferative LN...
  89. pmc Rats and mice immunised with chimeric human/mouse proteinase 3 produce autoantibodies to mouse Pr3 and rat granulocytes
    Ymke M van der Geld
    Department of Clinical Immunology, University Medical Center Groningen, Hanzeplein 1, 9713 GZ Groningen, The Netherlands
    Ann Rheum Dis 66:1679-82. 2007
    ..Aim: In this study, we employed chimeric human/mouse Proteinase 3 (PR3) proteins as tools to induce an autoantibody response to PR3 in rats and mice...
  90. pmc Reduced number and impaired function of circulating progenitor cells in patients with systemic lupus erythematosus
    Jan Renier A J Moonen
    Department of Pathology and Laboratory Medicine, University Medical Center Groningen, University of Groningen, The Netherlands
    Arthritis Res Ther 9:R84. 2007
    ..003). We conclude that CPC numbers are reduced in SLE patients and functionality is partly impaired. We suggest these findings reflect increased susceptibility to apoptosis of CPCs from SLE patients...
  91. ncbi CD4-positive effector memory T cells participate in disease expression in ANCA-associated vasculitis
    Wayel H Abdulahad
    Department of Rheumatology and Clinical Immunology, University Medical Center Groningen, Hanzeplein 1, 9713 GZ, Groningen, The Netherlands
    Ann N Y Acad Sci 1107:22-31. 2007
    ..Thus, CD4(+)T(EM) cells may act as inducers of tissue injury and participate in the development of AAV. Therapies that target CD4(+)T(EM), without impairing the activity of other lymphocyte subsets, may hold therapeutic promise for AAV...
  92. ncbi Relative contribution of attention-deficit hyperactivity disorder, obsessive-compulsive disorder, and tic severity to social and behavioral problems in tic disorders
    Pieter J Hoekstra
    Child and Adolescent Psychiatry Center, Groningen, The Netherlands
    J Dev Behav Pediatr 25:272-9. 2004
    ..There was no significant correlation between tic severity and ADHD severity. Thus, in patients with a tic disorder, the presence and severity of ADHD are the main predictors of associated behavioral and social problems...
  93. ncbi Influenza vaccination does not result in an increase in relapses in patients with ANCA-associated vasculitis
    Patricia M Stassen
    Department of Nephrology, University Medical Center Groningen, University of Groningen, PO Box 30001, 9700 RB, Groningen, The Netherlands
    Nephrol Dial Transplant 23:654-8. 2008
    ..In this study, we assessed whether vaccination against influenza increases the occurrence of relapses in patients with ANCA-associated vasculitis...
  94. ncbi Churg-Strauss syndrome: just one disease entity?
    Cees G M Kallenberg
    Arthritis Rheum 52:2589-93. 2005