Research Topics
| Marian JoelsSummaryAffiliation: University of Amsterdam Country: The Netherlands Publications
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Publications
Effects of chronic stress on structure and cell function in rat hippocampus and hypothalamusMarian Joels
SILS CNS, University of Amsterdam, The Netherlands
Stress 7:221-31. 2004..All of these endpoints provide potential targets for novel treatment strategies of stress-related brain disorders...- The coming out of the brain mineralocorticoid receptorMarian Joels
SILS CNS, University of Amsterdam, 1098 SM Amsterdam, The Netherlands
Trends Neurosci 31:1-7. 2008..This concept may explain why human carriers of a mineralocorticoid receptor gene variant display enhanced neuroendocrine and autonomic responsiveness to a psychological stressor... 
Functional actions of corticosteroids in the hippocampusMarian Joels
SILS CNS, University of Amsterdam, Kruislaan 320, 1098 SM Amsterdam, The Netherlands
Eur J Pharmacol 583:312-21. 2008..A better understanding of the corticosteroid actions could lead to a more rational treatment strategy of stress-related disorders...- Stress-induced changes in hippocampal functionMarian Joels
SILS CNS, University of Amsterdam, Amsterdam, The Netherlands
Prog Brain Res 167:3-15. 2008.... - Chronic stress: implications for neuronal morphology, function and neurogenesisMarian Joels
SILS CNS, University of Amsterdam, Kruislaan 320, 1098 SM Amsterdam, The Netherlands
Front Neuroendocrinol 28:72-96. 2007.... - Role of corticosteroid hormones in the dentate gyrusMarian Joels
Swammerdam Institute of Life Sciences, Center for Neuroscience, University of Amsterdam, Kruislaan 320, 1098 SM Amsterdam, The Netherlands
Prog Brain Res 163:355-70. 2007..These corticosteroid effects on dentate cell and network function are translated into behavioral consequences, in health and disease... - Corticosteroid effects in the brain: U-shape itMarian Joels
Swammerdam Institute for Life Sciences, Center for Neuroscience, University of Amsterdam, 1098 SM Amsterdam, The Netherlands
Trends Pharmacol Sci 27:244-50. 2006..This could result in dose dependencies with a different shape, despite the local presence of two receptor types... - Learning under stress: how does it work?Marian Joels
SILS CNS, University of Amsterdam, The Netherlands
Trends Cogn Sci 10:152-8. 2006..The mechanism of action of stress hormones, particularly corticosteroids, can explain how stress within the context of a learning experience induces focused attention and improves memory of relevant information... - Mineralocorticoid and glucocorticoid receptor-mediated effects on serotonergic transmission in health and diseaseMarian Joels
Swammerdam Institutes for Life Sciences, Section Neurobiology, University of Amsterdam, Kruislaan 320, 1098 SM, Amsterdam, The Netherlands
Ann N Y Acad Sci 1032:301-3. 2004..This may be relevant to the observation that hypercortisolism in humans is a risk factor for the precipitation of major depression in genetically predisposed individuals... - Acute stress increases calcium current amplitude in rat hippocampus: temporal changes in physiology and gene expressionM Joels
Swammerdam Institute for Life Sciences, University of Amsterdam, Kruislaan 320, 1098 SM Amsterdam, The Netherlands
Eur J Neurosci 18:1315-24. 2003..Prior to the functional change, increased expression of calcium channel subunits was observed, suggesting that the enhanced function could be explained by transcriptional regulation of the channels... - Hippocampal and hypothalamic function after chronic stressM Joels
Swammerdam Institute for Life Sciences, Section Neurobiology, University of Amsterdam, 1098 SM Amsterdam, The Netherlands
Ann N Y Acad Sci 1007:367-78. 2003..Follow-up studies will need to examine whether treatment with corticosteroid receptor antagonists can normalize the attenuated transmission after chronic stress... - Severe early life stress hampers spatial learning and neurogenesis, but improves hippocampal synaptic plasticity and emotional learning under high-stress conditions in adulthoodCharlotte A Oomen
Swammerdam Institute for Life Sciences, Center for Neuroscience, University of Amsterdam, 1098 XH Amsterdam, The Netherlands
J Neurosci 30:6635-45. 2010..Rather, adversity early in life can prepare the organism to perform optimally under conditions associated with high corticosteroid levels in adulthood... - Maternal care determines rapid effects of stress mediators on synaptic plasticity in adult rat hippocampal dentate gyrusRosemary C Bagot
SILS CNS, University of Amsterdam, Amsterdam, The Netherlands
Neurobiol Learn Mem 92:292-300. 2009..We suggest that decreased pup LG during postnatal life may be adaptive in high-threat environments, potentially enhancing hippocampal function in the offspring under conditions of adversity... 
Opposite effects of early maternal deprivation on neurogenesis in male versus female ratsCharlotte A Oomen
SILS Centre for Neuroscience, University of Amsterdam, Amsterdam, The Netherlands
PLoS ONE 4:e3675. 2009..o. in antidepressant action and is highly abundant early postnatally. We here tested the hypothesis that early life stress differentially affects hippocampal structural plasticity in female versus male offspring...- Early maternal deprivation affects dentate gyrus structure and emotional learning in adult female ratsCharlotte A Oomen
Swammerdam Institute for Life Sciences, Center for Neuroscience, University of Amsterdam, Amsterdam, The Netherlands
Psychopharmacology (Berl) 214:249-60. 2011..However, the underlying mechanisms that account for a reduced hippocampal volume are unknown... - Differential effects of corticosterone on the slow afterhyperpolarization in the basolateral amygdala and CA1 region: possible role of calcium channel subunitsLutz Liebmann
Swammerdam Institute for Life Sciences, Center for Neuroscience, University of Amsterdam, Amsterdam, The Netherlands
J Neurophysiol 99:958-68. 2008.... - Beta-adrenergic facilitation of synaptic plasticity in the rat basolateral amygdala in vitro is gradually reversed by corticosteroneZhenwei Pu
Swammerdam Institute for Life Sciences Center for Neuroscience, University of Amsterdam, Amsterdam 1098 SM, The Netherlands
Learn Mem 16:155-60. 2009..This suggests that in the basolateral amygdala, beta-adrenergic influences promote synaptic plasticity; this is gradually normalized by corticosterone, preventing the network from overshooting... - Corticosterone shifts different forms of synaptic potentiation in opposite directionsHarm J Krugers
Swammerdam Institute for Life Sciences, Center for Neuroscience, University of Amsterdam, The Netherlands
Hippocampus 15:697-703. 2005..We speculate that these opposite effects on synaptic efficacy are involved in the bidirectional modulation of cognitive performance by corticosteroid hormones... - Corticosterone reduces dendritic complexity in developing hippocampal CA1 neuronsDeborah N Alfarez
Swammerdam Institute for Life Sciences, Center for Neuroscience, Universiteit van Amsterdam, Amsterdam, The Netherlands
Hippocampus 19:828-36. 2009..These findings suggest that it is relevant to maintain plasma corticosterone levels low during hippocampal development... - Brief treatment with the glucocorticoid receptor antagonist mifepristone normalizes the reduction in neurogenesis after chronic stressCharlotte A Oomen
SILS Centre for Neuroscience, University of Amsterdam, Kruislaan 320, 1098 SM, Amsterdam, The Netherlands
Eur J Neurosci 26:3395-401. 2007..This neurogenic action of mifepristone could potentially contribute to its clinical mechanism of action... - Chronic stress attenuates GABAergic inhibition and alters gene expression of parvocellular neurons in rat hypothalamusJ Martin Verkuyl
Swammerdam Institute for Life Sciences, Neurobiology Section, Kruislaan 320, 1098 SM Amsterdam, The Netherlands
Eur J Neurosci 20:1665-73. 2004.... - Mineralocorticoid receptors are indispensable for nongenomic modulation of hippocampal glutamate transmission by corticosteroneHenk Karst
Swammerdam Institute for Life Sciences, Center for Neurosciences SILS CNS, University of Amsterdam, Kruislaan 320, 1098 SM Amsterdam, The Netherlands
Proc Natl Acad Sci U S A 102:19204-7. 2005..Rapid actions by corticosterone would allow the brain to change its function within minutes after stress-induced elevations of corticosteroid levels, in addition to responding later through gene-mediated signaling pathways... - Effects of corticosterone and the beta-agonist isoproterenol on glutamate receptor-mediated synaptic currents in the rat basolateral amygdalaLutz Liebmann
SILS CNS, University of Amsterdam, Amsterdam, The Netherlands
Eur J Neurosci 30:800-7. 2009.... - Brief RU 38486 treatment normalizes the effects of chronic stress on calcium currents in rat hippocampal CA1 neuronsHenk Karst
SILS CNS, University of Amsterdam, Amsterdam, The Netherlands
Neuropsychopharmacology 32:1830-9. 2007..In conclusion, the data indicate that chronic stress, RU 38486 treatment as well as acute rises in corticosterone level strongly modulate calcium influx into CA1 neurons. This could have consequences for the viability of these neurons... - Glucocorticoids specifically enhance L-type calcium current amplitude and affect calcium channel subunit expression in the mouse hippocampusPascal Chameau
Swamnerdam Institute for Life Science and Center for NeuroScience, University of Amsterdam, Kruislaan 320, 1098 SM Amsterdam, The Netherlands
J Neurophysiol 97:5-14. 2007..This indicates that the corticosteroid-induced increase in number of L-type calcium channels is not caused by a simple transcriptional regulation of the pore-forming subunit of the channels... - Glucocorticoids alter calcium conductances and calcium channel subunit expression in basolateral amygdala neuronsHenk Karst
Section Neurobiology, Swammerdam Institute for Life Sciences, University of Amsterdam, the Netherlands Department Pharmacology and Toxicology, University of Texas Medical Branch, Galveston, USA
Eur J Neurosci 16:1083-9. 2002..These actions could modify amygdala network function and thus contribute to the behavioural effects exerted by the stress hormones via the basolateral amygdala... - Chronic unpredictable stress alters gene expression in rat single dentate granule cellsYongjun Qin
Section Neurobiology, Swammerdam Institute for Life Sciences, Faculty of Science, University of Amsterdam, Amsterdam, The Netherlands
J Neurochem 89:364-74. 2004..This could contribute to enhanced excitability and vulnerability of granule cells after chronic stress... - Effect of early life stress on serotonin responses in the hippocampus of young adult ratsEls Van Riel
Swammerdam Institute for Life Sciences, University of Amsterdam, 1098 SM Amsterdam, The Netherlands
Synapse 53:11-9. 2004.... - Timing is essential for rapid effects of corticosterone on synaptic potentiation in the mouse hippocampusOlof Wiegert
Swammerdam Institute for Life Sciences, Center for Neuroscience, University of Amsterdam, Kruislaan 320, 1098 SM Amsterdam, The Netherlands
Learn Mem 13:110-3. 2006..These data provide a biological substrate for the important behavioral observation that stress and corticosteroid hormones can facilitate learning and memory processes... - Corticosterone time-dependently modulates beta-adrenergic effects on long-term potentiation in the hippocampal dentate gyrusZhenwei Pu
Swammerdam Institute for Life Sciences, Center for Neuroscience, University of Amsterdam, SM Amsterdam, The Netherlands
Learn Mem 14:359-67. 2007..This emphasizes that corticosterone can regulate beta-adrenergic modulation of synaptic plasticity in opposite directions, depending on the timing of hormone application... - Both mineralocorticoid and glucocorticoid receptors regulate emotional memory in miceMing Zhou
Swammerdam Institute for Life Sciences, Center for Neuroscience, University of Amsterdam, Science Park, 1098 XH Amsterdam, The Netherlands
Neurobiol Learn Mem 94:530-7. 2010..These results reveal that - in addition to GRs - MRs also play a critical role in establishing fear memories, particularly in the early phase of memory formation... - Maternal deprivation and dendritic complexity in the basolateral amygdalaHarm J Krugers
Swammerdam Institute for Life Sciences, Center for Neuroscience, University of Amsterdam, Science Park 904, 1098 XH Amsterdam, The Netherlands
Neuropharmacology 62:534-7. 2012..Since the amygdala is critically involved in fear conditioning we examined here whether maternal deprivation regulates dendritic complexity in this area... - Distinct structural plasticity in the hippocampus and amygdala of the middle-aged common marmoset (Callithrix jacchus)Michael W Marlatt
Swammerdam Institute for Life Science Center for Neuroscience, University of Amsterdam, Amsterdam, The Netherlands
Exp Neurol 230:291-301. 2011.... - Effect of brief corticosterone administration on SGK1 and RGS4 mRNA expression in rat hippocampusNeeltje G van Gemert
Swammerdam Institute for Life Sciences, University of Amsterdam, Amsterdam, The Netherlands
Stress 9:165-70. 2006..Strikingly, SGK1 mRNA expression was strongly up-regulated in the corpus callosum. We reject, however, the hypothesis that the effect of corticosterone on 5-HT1A responsiveness is mediated via altered RGS4 or SGK1 mRNA expression... - Chronic stress in the adult dentate gyrus reduces cell proliferation near the vasculature and VEGF and Flk-1 protein expressionVivi M Heine
Institute Neurobiology, Swammerdam Institute for Life Sciences, University of Amsterdam, Kruislaan 320, 1098 SM Amsterdam, The Netherlands
Eur J Neurosci 21:1304-14. 2005..This demonstrates that changes in angiogenic factors are implicated in the decreased adult proliferation found after chronic stress... - Prominent decline of newborn cell proliferation, differentiation, and apoptosis in the aging dentate gyrus, in absence of an age-related hypothalamus-pituitary-adrenal axis activationVivi M Heine
Institute for Neurobiology, Faculty of Science, Swammerdam Institute for Life Sciences, University of Amsterdam, Kruislaan 320, 1098 SM, Amsterdam, The Netherlands
Neurobiol Aging 25:361-75. 2004..Surprisingly, we found no correlation between cell birth and corticosterone levels or stress response parameters in any age group... - Dissociation between rat hippocampal CA1 and dentate gyrus cells in their response to corticosterone: effects on calcium channel protein and currentNeeltje G van Gemert
Swammerdam Institute for Life Sciences, University of Amsterdam, 1098 SM Amsterdam, The Netherlands
Endocrinology 150:4615-24. 2009.... - Fear conditioning enhances spontaneous AMPA receptor-mediated synaptic transmission in mouse hippocampal CA1 areaMing Zhou
Swammerdam Institute for Life Sciences, Center for Neuroscience, Amsterdam, The Netherlands
Eur J Neurosci 30:1559-64. 2009..This implies that learning the association between context, tone and footshock transiently enhances hippocampal CA1 spontaneous synaptic transmission, which may contribute to the encoding of the fearful event... - Increased proliferation reflects glial and vascular-associated changes, but not neurogenesis in the presenile Alzheimer hippocampusKarin Boekhoorn
Center for Neuroscience, Swammerdam Institute of Life Sciences, University of Amsterdam, Kruislaan 320, 1098 SM Amsterdam, The Netherlands
Neurobiol Dis 24:1-14. 2006..They reflect clear differences in proliferative responsivity, particularly in the glia and vascular components, and suggest different underlying mechanisms in these groups... - Effect of chronic stress on synaptic currents in rat hippocampal dentate gyrus neuronsHenk Karst
Swammerdam Institute for Life Sciences, University of Amsterdam, The Netherlands
J Neurophysiol 89:625-33. 2003..This enhanced synaptic flow could contribute to enhanced excitation of projection areas of the dentate gyrus, most notably the CA3 hippocampal region... - GABAergic transmission in the rat paraventricular nucleus of the hypothalamus is suppressed by corticosterone and stressJ Martin Verkuyl
Swammerdam Institute for Life Sciences, Section Neurobiology, University of Amsterdam, Kruislaan 320, 1098 SM Amsterdam, The Netherlands
Eur J Neurosci 21:113-21. 2005.... - Adult hippocampal glucocorticoid receptor expression and dentate synaptic plasticity correlate with maternal care received by individuals early in lifeFelisa N van Hasselt
SILS CNS, University of Amsterdam, Amsterdam, The Netherlands
Hippocampus 22:255-66. 2012..We conclude that even moderate variations in early life environment have a major impact on adult hippocampal function. This principle could provide a mechanistic basis for individual differences in susceptibility to psychopathology... - Corticosteroid hormones, synaptic strength and emotional memories: corticosteroid modulation of memory -- a cellular and molecular perspectiveOlof Wiegert
Swammerdam Institute for Life Sciences, SILS CNS, Universiteit van Amsterdam, Kruislaan 320, 1098 SM, Amsterdam, The Netherlands
Prog Brain Res 167:269-71. 2008..Based on recent findings we propose a model in which corticosterone can rapidly enhance synaptic plasticity. Later, corticosterone may stabilize synaptic efficacy, possibly at the expense of reduced synaptic plasticity... - Suppressed proliferation and apoptotic changes in the rat dentate gyrus after acute and chronic stress are reversibleVivi M Heine
Institute for Neurobiology, Swammerdam Institute for Life Sciences, University of Amsterdam, Kruislaan 320, 1098 SM Amsterdam, The Netherlands
Eur J Neurosci 19:131-44. 2004..This may have important implications for our understanding of the reversibility of stress-related hippocampal volume changes, such as occur, for example, in depression... - Corticosterone slowly enhances miniature excitatory postsynaptic current amplitude in mice CA1 hippocampal cellsHenk Karst
Center for Neuroscience, Swammerdam Institute for Life Sciences, University of Amsterdam, Kruislaan 320, 1098 SM Amsterdam, The Netherlands
J Neurophysiol 94:3479-86. 2005..In summary, the present results show that activation of hippocampal glucocorticoid receptors induces a slow enhancement of AMPA-receptor-mediated responses, at the single-cell level... - Corticosteroid effects on cellular physiology of limbic cellsMarian Joels
SILS CNS, University of Amsterdam, Kruislaan 320, 1098 SM Amsterdam, The Netherlands
Brain Res 1293:91-100. 2009..Finally, the time- and region-specific corticosteroid actions strongly depend on the individual's life history... - Combined β-adrenergic and corticosteroid receptor activation regulates AMPA receptor function in hippocampal neuronsMing Zhou
Swammerdam Institute for Life Sciences, Center for Neuroscience, University of Amsterdam, Amsterdam, The Netherlands
J Psychopharmacol 26:516-24. 2012..These combined hormonal effects on glutamate transmission might contribute to their memory-enhancing effects... - Blocking mineralocorticoid receptors prior to retrieval reduces contextual fear memory in miceMing Zhou
Center for Neuroscience, Swammerdam Institute for Life Sciences, University of Amsterdam, Amsterdam, The Netherlands
PLoS ONE 6:e26220. 2011..We tested here whether blockade of MRs or GRs during retrieval also affects subsequent expression of fear memory... - Maternal care and hippocampal plasticity: evidence for experience-dependent structural plasticity, altered synaptic functioning, and differential responsiveness to glucocorticoids and stressDanielle L Champagne
Swammerdam Institute for Life Sciences Center for Neuroscience, University of Amsterdam, 1098 SM Amsterdam, The Netherlands
J Neurosci 28:6037-45. 2008.... - Chronic unpredictable stress impairs long-term potentiation in rat hippocampal CA1 area and dentate gyrus in vitroDeborah N Alfarez
Swammerdam Institute for Life Sciences, Section Neurobiology, University of Amsterdam, The Netherlands
Eur J Neurosci 17:1928-34. 2003..It is tempting to speculate that the stress-induced reduction of hippocampal efficacy provides a cellular substrate for cognitive deficits in hippocampus-dependent learning tasks seen after prolonged exposure to stressful events... - Gene expression patterns in rat dentate granule cells: comparison between fresh and fixed tissueYongjun Qin
Section Neurobiology, Swammerdam Institute for Life Sciences, University of Amsterdam, Kruislaan 320, 1098SM Amsterdam, The Netherlands
J Neurosci Methods 131:205-11. 2003..The present approach validates expression profiling from small amounts of fixed neurons as a powerful tool to investigate molecular processes if fresh tissue is not available... - No effect of prolonged corticosterone over-exposure on NCAM, SGK1, and RGS4 mRNA expression in rat hippocampusNeeltje G van Gemert
Swammerdam Institute for Life Sciences, Center for NeuroScience University of Amsterdam Kruislaan 320, 1098 SM Amsterdam, The Netherlands
Brain Res 1093:161-6. 2006..We found that the expression of none of these candidates was affected by corticosterone treatment... - Individual variations in maternal care early in life correlate with later life decision-making and c-fos expression in prefrontal subregions of ratsFelisa N van Hasselt
SILS CNS, University of Amsterdam, Amsterdam, The Netherlands
PLoS ONE 7:e37820. 2012..We conclude that natural variations in maternal care received by pups may significantly contribute to later-life decision-making and activity of underlying brain structures... - Gene expression changes in single dentate granule neurons after adrenalectomy of ratsYongjun Qin
Swammerdam Institute for Life Science, Section Neurobiology, University of Amsterdam, Kruislaan 320, 1098 SM Amsterdam, The Netherlands
Brain Res Mol Brain Res 111:17-23. 2003.... - Interacting noradrenergic and corticosteroid systems shift human brain activation patterns during encodingAnda H van Stegeren
University of Amsterdam, Department of Clinical Psychology, Roetersstraat 15, 1018 WB Amsterdam, The Netherlands
Neurobiol Learn Mem 93:56-65. 2010.... - Improved long-term potentiation and memory in young tau-P301L transgenic mice before onset of hyperphosphorylation and tauopathyKarin Boekhoorn
Swammerdam Institute for Life Sciences, Center for Neuroscience, University of Amsterdam, 1098 SM Amsterdam, The Netherlands
J Neurosci 26:3514-23. 2006.... 
LTP after stress: up or down?Marian Joels
SILS CNS, University of Amsterdam, Amsterdam, The Netherlands
Neural Plast 2007:93202. 2007..Many factors, including the type of stress, the phase of the stress response, the area of investigation, type of LTP, and the life history of the organism determine in which direction LTP will be changed...- Stress, depression and hippocampal apoptosisPaul J Lucassen
Centre for Neuroscience, Swammerdam Institute for Life Sciences, University of Amsterdam, Amsterdam, The Netherlands
CNS Neurol Disord Drug Targets 5:531-46. 2006..Modulation of apoptosis and neurogenesis, by drugs interfering with stress components like MR and/or GR, and/or mediators of the cell death cascade, may therefore provide important drug targets for the modulation of mood and memory... - Stress, the hippocampus, and epilepsyMarian Joels
SILS CNS, University of Amsterdam, The Netherlands
Epilepsia 50:586-97. 2009..It will be interesting to examine how curtailing the effects of stress in adults, for example, by brief treatment with antiglucocorticoids, may be beneficial to the treatment of epilepsy... - The neuro-symphony of stressMarian Joels
SILS CNS, University of Amsterdam, The Netherlands
Nat Rev Neurosci 10:459-66. 2009..Together, this results in the stress instruments producing an orchestrated 'symphony' that enables fine-tuned responses to diverse challenges... - Regulation of excitatory synapses and fearful memories by stress hormonesHarm J Krugers
Center for Neuroscience, Swammerdam Institute for Life Sciences, University of Amsterdam Amsterdam, Netherlands
Front Behav Neurosci 5:62. 2011..Here we will review how glucocorticoids and norepinephrine regulate the formation of fearful memories in rodents and humans and how these hormones can facilitate the storage of information by regulating excitatory synapses... - Chronic stress effects on hippocampal structure and synaptic function: relevance for depression and normalization by anti-glucocorticoid treatmentHarmen J Krugers
Center for Neuroscience, Swammerdam Institute for Life Sciences, University of Amsterdam Amsterdam, Netherlands
Front Synaptic Neurosci 2:24. 2010.... - Interactions between noradrenaline and corticosteroids in the brain: from electrical activity to cognitive performanceHarm J Krugers
Center for Neuroscience, Swammerdam Institute for Life Sciences, University of Amsterdam, Amsterdam, Netherlands
Front Cell Neurosci 6:15. 2012.... - A single-day treatment with mifepristone is sufficient to normalize chronic glucocorticoid induced suppression of hippocampal cell proliferationPu Hu
Swammerdam Institute for Life Sciences, Center for Neuroscience, University of Amsterdam, Amsterdam, The Netherlands CAS Key Laboratory of Brain Function and Diseases, School of Life Science, University of Science and Technology of China, Hefei, Anhui, China
PLoS ONE 7:e46224. 2012..Here we aimed to better understand how mifepristone achieves this effect and questioned whether an even shorter (single day) mifepristone treatment (instead of 4 days) also suffices to normalize neurogenesis...