Marian Joels

Summary

Affiliation: University of Amsterdam
Country: The Netherlands

Publications

  1. pmc LTP after stress: up or down?
    Marian Joels
    SILS CNS, University of Amsterdam, Amsterdam, The Netherlands
    Neural Plast 2007:93202. 2007
  2. ncbi Effects of chronic stress on structure and cell function in rat hippocampus and hypothalamus
    Marian Joels
    SILS CNS, University of Amsterdam, The Netherlands
    Stress 7:221-31. 2004
  3. ncbi Corticosteroid effects in the brain: U-shape it
    Marian Joels
    Swammerdam Institute for Life Sciences, Center for Neuroscience, University of Amsterdam, 1098 SM Amsterdam, The Netherlands
    Trends Pharmacol Sci 27:244-50. 2006
  4. ncbi Chronic stress: implications for neuronal morphology, function and neurogenesis
    Marian Joels
    SILS CNS, University of Amsterdam, Kruislaan 320, 1098 SM Amsterdam, The Netherlands
    Front Neuroendocrinol 28:72-96. 2007
  5. ncbi Learning under stress: how does it work?
    Marian Joels
    SILS CNS, University of Amsterdam, The Netherlands
    Trends Cogn Sci 10:152-8. 2006
  6. ncbi Stress-induced changes in hippocampal function
    Marian Joels
    SILS CNS, University of Amsterdam, Amsterdam, The Netherlands
    Prog Brain Res 167:3-15. 2008
  7. ncbi Mineralocorticoid and glucocorticoid receptor-mediated effects on serotonergic transmission in health and disease
    Marian Joels
    Swammerdam Institutes for Life Sciences, Section Neurobiology, University of Amsterdam, Kruislaan 320, 1098 SM, Amsterdam, The Netherlands
    Ann N Y Acad Sci 1032:301-3. 2004
  8. ncbi Role of corticosteroid hormones in the dentate gyrus
    Marian Joels
    Swammerdam Institute of Life Sciences, Center for Neuroscience, University of Amsterdam, Kruislaan 320, 1098 SM Amsterdam, The Netherlands
    Prog Brain Res 163:355-70. 2007
  9. ncbi The coming out of the brain mineralocorticoid receptor
    Marian Joels
    SILS CNS, University of Amsterdam, 1098 SM Amsterdam, The Netherlands
    Trends Neurosci 31:1-7. 2008
  10. ncbi Hippocampal and hypothalamic function after chronic stress
    M Joels
    Swammerdam Institute for Life Sciences, Section Neurobiology, University of Amsterdam, 1098 SM Amsterdam, The Netherlands
    Ann N Y Acad Sci 1007:367-78. 2003

Detail Information

Publications65

  1. pmc LTP after stress: up or down?
    Marian Joels
    SILS CNS, University of Amsterdam, Amsterdam, The Netherlands
    Neural Plast 2007:93202. 2007
    ..Many factors, including the type of stress, the phase of the stress response, the area of investigation, type of LTP, and the life history of the organism determine in which direction LTP will be changed...
  2. ncbi Effects of chronic stress on structure and cell function in rat hippocampus and hypothalamus
    Marian Joels
    SILS CNS, University of Amsterdam, The Netherlands
    Stress 7:221-31. 2004
    ..All of these endpoints provide potential targets for novel treatment strategies of stress-related brain disorders...
  3. ncbi Corticosteroid effects in the brain: U-shape it
    Marian Joels
    Swammerdam Institute for Life Sciences, Center for Neuroscience, University of Amsterdam, 1098 SM Amsterdam, The Netherlands
    Trends Pharmacol Sci 27:244-50. 2006
    ..This could result in dose dependencies with a different shape, despite the local presence of two receptor types...
  4. ncbi Chronic stress: implications for neuronal morphology, function and neurogenesis
    Marian Joels
    SILS CNS, University of Amsterdam, Kruislaan 320, 1098 SM Amsterdam, The Netherlands
    Front Neuroendocrinol 28:72-96. 2007
    ....
  5. ncbi Learning under stress: how does it work?
    Marian Joels
    SILS CNS, University of Amsterdam, The Netherlands
    Trends Cogn Sci 10:152-8. 2006
    ..The mechanism of action of stress hormones, particularly corticosteroids, can explain how stress within the context of a learning experience induces focused attention and improves memory of relevant information...
  6. ncbi Stress-induced changes in hippocampal function
    Marian Joels
    SILS CNS, University of Amsterdam, Amsterdam, The Netherlands
    Prog Brain Res 167:3-15. 2008
    ....
  7. ncbi Mineralocorticoid and glucocorticoid receptor-mediated effects on serotonergic transmission in health and disease
    Marian Joels
    Swammerdam Institutes for Life Sciences, Section Neurobiology, University of Amsterdam, Kruislaan 320, 1098 SM, Amsterdam, The Netherlands
    Ann N Y Acad Sci 1032:301-3. 2004
    ..This may be relevant to the observation that hypercortisolism in humans is a risk factor for the precipitation of major depression in genetically predisposed individuals...
  8. ncbi Role of corticosteroid hormones in the dentate gyrus
    Marian Joels
    Swammerdam Institute of Life Sciences, Center for Neuroscience, University of Amsterdam, Kruislaan 320, 1098 SM Amsterdam, The Netherlands
    Prog Brain Res 163:355-70. 2007
    ..These corticosteroid effects on dentate cell and network function are translated into behavioral consequences, in health and disease...
  9. ncbi The coming out of the brain mineralocorticoid receptor
    Marian Joels
    SILS CNS, University of Amsterdam, 1098 SM Amsterdam, The Netherlands
    Trends Neurosci 31:1-7. 2008
    ..This concept may explain why human carriers of a mineralocorticoid receptor gene variant display enhanced neuroendocrine and autonomic responsiveness to a psychological stressor...
  10. ncbi Hippocampal and hypothalamic function after chronic stress
    M Joels
    Swammerdam Institute for Life Sciences, Section Neurobiology, University of Amsterdam, 1098 SM Amsterdam, The Netherlands
    Ann N Y Acad Sci 1007:367-78. 2003
    ..Follow-up studies will need to examine whether treatment with corticosteroid receptor antagonists can normalize the attenuated transmission after chronic stress...
  11. doi Functional actions of corticosteroids in the hippocampus
    Marian Joels
    SILS CNS, University of Amsterdam, Kruislaan 320, 1098 SM Amsterdam, The Netherlands
    Eur J Pharmacol 583:312-21. 2008
    ..A better understanding of the corticosteroid actions could lead to a more rational treatment strategy of stress-related disorders...
  12. ncbi Acute stress increases calcium current amplitude in rat hippocampus: temporal changes in physiology and gene expression
    M Joels
    Swammerdam Institute for Life Sciences, University of Amsterdam, Kruislaan 320, 1098 SM Amsterdam, The Netherlands
    Eur J Neurosci 18:1315-24. 2003
    ..Prior to the functional change, increased expression of calcium channel subunits was observed, suggesting that the enhanced function could be explained by transcriptional regulation of the channels...
  13. ncbi Chronic unpredictable stress alters gene expression in rat single dentate granule cells
    Yongjun Qin
    Section Neurobiology, Swammerdam Institute for Life Sciences, Faculty of Science, University of Amsterdam, Amsterdam, The Netherlands
    J Neurochem 89:364-74. 2004
    ..This could contribute to enhanced excitability and vulnerability of granule cells after chronic stress...
  14. ncbi Severe early life stress hampers spatial learning and neurogenesis, but improves hippocampal synaptic plasticity and emotional learning under high-stress conditions in adulthood
    Charlotte A Oomen
    Swammerdam Institute for Life Sciences, Center for Neuroscience, University of Amsterdam, 1098 XH Amsterdam, The Netherlands
    J Neurosci 30:6635-45. 2010
    ..Rather, adversity early in life can prepare the organism to perform optimally under conditions associated with high corticosteroid levels in adulthood...
  15. ncbi GABAergic transmission in the rat paraventricular nucleus of the hypothalamus is suppressed by corticosterone and stress
    J Martin Verkuyl
    Swammerdam Institute for Life Sciences, Section Neurobiology, University of Amsterdam, Kruislaan 320, 1098 SM Amsterdam, The Netherlands
    Eur J Neurosci 21:113-21. 2005
    ....
  16. ncbi Glucocorticoids alter calcium conductances and calcium channel subunit expression in basolateral amygdala neurons
    Henk Karst
    Section Neurobiology, Swammerdam Institute for Life Sciences, University of Amsterdam, the Netherlands Department Pharmacology and Toxicology, University of Texas Medical Branch, Galveston, USA
    Eur J Neurosci 16:1083-9. 2002
    ..These actions could modify amygdala network function and thus contribute to the behavioural effects exerted by the stress hormones via the basolateral amygdala...
  17. ncbi Maternal care determines rapid effects of stress mediators on synaptic plasticity in adult rat hippocampal dentate gyrus
    Rosemary C Bagot
    SILS CNS, University of Amsterdam, Amsterdam, The Netherlands
    Neurobiol Learn Mem 92:292-300. 2009
    ..We suggest that decreased pup LG during postnatal life may be adaptive in high-threat environments, potentially enhancing hippocampal function in the offspring under conditions of adversity...
  18. pmc Opposite effects of early maternal deprivation on neurogenesis in male versus female rats
    Charlotte A Oomen
    SILS Centre for Neuroscience, University of Amsterdam, Amsterdam, The Netherlands
    PLoS ONE 4:e3675. 2009
    ..o. in antidepressant action and is highly abundant early postnatally. We here tested the hypothesis that early life stress differentially affects hippocampal structural plasticity in female versus male offspring...
  19. pmc Early maternal deprivation affects dentate gyrus structure and emotional learning in adult female rats
    Charlotte A Oomen
    Swammerdam Institute for Life Sciences, Center for Neuroscience, University of Amsterdam, Amsterdam, The Netherlands
    Psychopharmacology (Berl) 214:249-60. 2011
    ..However, the underlying mechanisms that account for a reduced hippocampal volume are unknown...
  20. ncbi Differential effects of corticosterone on the slow afterhyperpolarization in the basolateral amygdala and CA1 region: possible role of calcium channel subunits
    Lutz Liebmann
    Swammerdam Institute for Life Sciences, Center for Neuroscience, University of Amsterdam, Amsterdam, The Netherlands
    J Neurophysiol 99:958-68. 2008
    ....
  21. ncbi Chronic stress attenuates GABAergic inhibition and alters gene expression of parvocellular neurons in rat hypothalamus
    J Martin Verkuyl
    Swammerdam Institute for Life Sciences, Neurobiology Section, Kruislaan 320, 1098 SM Amsterdam, The Netherlands
    Eur J Neurosci 20:1665-73. 2004
    ....
  22. ncbi Corticosterone shifts different forms of synaptic potentiation in opposite directions
    Harm J Krugers
    Swammerdam Institute for Life Sciences, Center for Neuroscience, University of Amsterdam, The Netherlands
    Hippocampus 15:697-703. 2005
    ..We speculate that these opposite effects on synaptic efficacy are involved in the bidirectional modulation of cognitive performance by corticosteroid hormones...
  23. doi Beta-adrenergic facilitation of synaptic plasticity in the rat basolateral amygdala in vitro is gradually reversed by corticosterone
    Zhenwei Pu
    Swammerdam Institute for Life Sciences Center for Neuroscience, University of Amsterdam, Amsterdam 1098 SM, The Netherlands
    Learn Mem 16:155-60. 2009
    ..This suggests that in the basolateral amygdala, beta-adrenergic influences promote synaptic plasticity; this is gradually normalized by corticosterone, preventing the network from overshooting...
  24. ncbi Effect of chronic stress on synaptic currents in rat hippocampal dentate gyrus neurons
    Henk Karst
    Swammerdam Institute for Life Sciences, University of Amsterdam, The Netherlands
    J Neurophysiol 89:625-33. 2003
    ..This enhanced synaptic flow could contribute to enhanced excitation of projection areas of the dentate gyrus, most notably the CA3 hippocampal region...
  25. ncbi Corticosterone reduces dendritic complexity in developing hippocampal CA1 neurons
    Deborah N Alfarez
    Swammerdam Institute for Life Sciences, Center for Neuroscience, Universiteit van Amsterdam, Amsterdam, The Netherlands
    Hippocampus 19:828-36. 2009
    ..These findings suggest that it is relevant to maintain plasma corticosterone levels low during hippocampal development...
  26. ncbi Brief treatment with the glucocorticoid receptor antagonist mifepristone normalizes the reduction in neurogenesis after chronic stress
    Charlotte A Oomen
    SILS Centre for Neuroscience, University of Amsterdam, Kruislaan 320, 1098 SM, Amsterdam, The Netherlands
    Eur J Neurosci 26:3395-401. 2007
    ..This neurogenic action of mifepristone could potentially contribute to its clinical mechanism of action...
  27. ncbi Brief RU 38486 treatment normalizes the effects of chronic stress on calcium currents in rat hippocampal CA1 neurons
    Henk Karst
    SILS CNS, University of Amsterdam, Amsterdam, The Netherlands
    Neuropsychopharmacology 32:1830-9. 2007
    ..In conclusion, the data indicate that chronic stress, RU 38486 treatment as well as acute rises in corticosterone level strongly modulate calcium influx into CA1 neurons. This could have consequences for the viability of these neurons...
  28. ncbi Glucocorticoids specifically enhance L-type calcium current amplitude and affect calcium channel subunit expression in the mouse hippocampus
    Pascal Chameau
    Swamnerdam Institute for Life Science and Center for NeuroScience, University of Amsterdam, Kruislaan 320, 1098 SM Amsterdam, The Netherlands
    J Neurophysiol 97:5-14. 2007
    ..This indicates that the corticosteroid-induced increase in number of L-type calcium channels is not caused by a simple transcriptional regulation of the pore-forming subunit of the channels...
  29. doi Effects of corticosterone and the beta-agonist isoproterenol on glutamate receptor-mediated synaptic currents in the rat basolateral amygdala
    Lutz Liebmann
    SILS CNS, University of Amsterdam, Amsterdam, The Netherlands
    Eur J Neurosci 30:800-7. 2009
    ....
  30. pmc Mineralocorticoid receptors are indispensable for nongenomic modulation of hippocampal glutamate transmission by corticosterone
    Henk Karst
    Swammerdam Institute for Life Sciences, Center for Neurosciences SILS CNS, University of Amsterdam, Kruislaan 320, 1098 SM Amsterdam, The Netherlands
    Proc Natl Acad Sci U S A 102:19204-7. 2005
    ..Rapid actions by corticosterone would allow the brain to change its function within minutes after stress-induced elevations of corticosteroid levels, in addition to responding later through gene-mediated signaling pathways...
  31. ncbi Timing is essential for rapid effects of corticosterone on synaptic potentiation in the mouse hippocampus
    Olof Wiegert
    Swammerdam Institute for Life Sciences, Center for Neuroscience, University of Amsterdam, Kruislaan 320, 1098 SM Amsterdam, The Netherlands
    Learn Mem 13:110-3. 2006
    ..These data provide a biological substrate for the important behavioral observation that stress and corticosteroid hormones can facilitate learning and memory processes...
  32. doi Both mineralocorticoid and glucocorticoid receptors regulate emotional memory in mice
    Ming Zhou
    Swammerdam Institute for Life Sciences, Center for Neuroscience, University of Amsterdam, Science Park, 1098 XH Amsterdam, The Netherlands
    Neurobiol Learn Mem 94:530-7. 2010
    ..These results reveal that - in addition to GRs - MRs also play a critical role in establishing fear memories, particularly in the early phase of memory formation...
  33. ncbi Effect of early life stress on serotonin responses in the hippocampus of young adult rats
    Els Van Riel
    Swammerdam Institute for Life Sciences, University of Amsterdam, 1098 SM Amsterdam, The Netherlands
    Synapse 53:11-9. 2004
    ....
  34. pmc Corticosterone time-dependently modulates beta-adrenergic effects on long-term potentiation in the hippocampal dentate gyrus
    Zhenwei Pu
    Swammerdam Institute for Life Sciences, Center for Neuroscience, University of Amsterdam, SM Amsterdam, The Netherlands
    Learn Mem 14:359-67. 2007
    ..This emphasizes that corticosterone can regulate beta-adrenergic modulation of synaptic plasticity in opposite directions, depending on the timing of hormone application...
  35. doi Maternal deprivation and dendritic complexity in the basolateral amygdala
    Harm J Krugers
    Swammerdam Institute for Life Sciences, Center for Neuroscience, University of Amsterdam, Science Park 904, 1098 XH Amsterdam, The Netherlands
    Neuropharmacology 62:534-7. 2012
    ..Since the amygdala is critically involved in fear conditioning we examined here whether maternal deprivation regulates dendritic complexity in this area...
  36. ncbi Chronic stress in the adult dentate gyrus reduces cell proliferation near the vasculature and VEGF and Flk-1 protein expression
    Vivi M Heine
    Institute Neurobiology, Swammerdam Institute for Life Sciences, University of Amsterdam, Kruislaan 320, 1098 SM Amsterdam, The Netherlands
    Eur J Neurosci 21:1304-14. 2005
    ..This demonstrates that changes in angiogenic factors are implicated in the decreased adult proliferation found after chronic stress...
  37. doi Distinct structural plasticity in the hippocampus and amygdala of the middle-aged common marmoset (Callithrix jacchus)
    Michael W Marlatt
    Swammerdam Institute for Life Science Center for Neuroscience, University of Amsterdam, Amsterdam, The Netherlands
    Exp Neurol 230:291-301. 2011
    ....
  38. ncbi Prominent decline of newborn cell proliferation, differentiation, and apoptosis in the aging dentate gyrus, in absence of an age-related hypothalamus-pituitary-adrenal axis activation
    Vivi M Heine
    Institute for Neurobiology, Faculty of Science, Swammerdam Institute for Life Sciences, University of Amsterdam, Kruislaan 320, 1098 SM, Amsterdam, The Netherlands
    Neurobiol Aging 25:361-75. 2004
    ..Surprisingly, we found no correlation between cell birth and corticosterone levels or stress response parameters in any age group...
  39. ncbi Effect of brief corticosterone administration on SGK1 and RGS4 mRNA expression in rat hippocampus
    Neeltje G van Gemert
    Swammerdam Institute for Life Sciences, University of Amsterdam, Amsterdam, The Netherlands
    Stress 9:165-70. 2006
    ..Strikingly, SGK1 mRNA expression was strongly up-regulated in the corpus callosum. We reject, however, the hypothesis that the effect of corticosterone on 5-HT1A responsiveness is mediated via altered RGS4 or SGK1 mRNA expression...
  40. pmc Dissociation between rat hippocampal CA1 and dentate gyrus cells in their response to corticosterone: effects on calcium channel protein and current
    Neeltje G van Gemert
    Swammerdam Institute for Life Sciences, University of Amsterdam, 1098 SM Amsterdam, The Netherlands
    Endocrinology 150:4615-24. 2009
    ....
  41. ncbi Fear conditioning enhances spontaneous AMPA receptor-mediated synaptic transmission in mouse hippocampal CA1 area
    Ming Zhou
    Swammerdam Institute for Life Sciences, Center for Neuroscience, Amsterdam, The Netherlands
    Eur J Neurosci 30:1559-64. 2009
    ..This implies that learning the association between context, tone and footshock transiently enhances hippocampal CA1 spontaneous synaptic transmission, which may contribute to the encoding of the fearful event...
  42. ncbi Increased proliferation reflects glial and vascular-associated changes, but not neurogenesis in the presenile Alzheimer hippocampus
    Karin Boekhoorn
    Center for Neuroscience, Swammerdam Institute of Life Sciences, University of Amsterdam, Kruislaan 320, 1098 SM Amsterdam, The Netherlands
    Neurobiol Dis 24:1-14. 2006
    ..They reflect clear differences in proliferative responsivity, particularly in the glia and vascular components, and suggest different underlying mechanisms in these groups...
  43. pmc A single-day treatment with mifepristone is sufficient to normalize chronic glucocorticoid induced suppression of hippocampal cell proliferation
    Pu Hu
    Swammerdam Institute for Life Sciences, Center for Neuroscience, University of Amsterdam, Amsterdam, The Netherlands
    PLoS ONE 7:e46224. 2012
    ..Here we aimed to better understand how mifepristone achieves this effect and questioned whether an even shorter (single day) mifepristone treatment (instead of 4 days) also suffices to normalize neurogenesis...
  44. ncbi Adult hippocampal glucocorticoid receptor expression and dentate synaptic plasticity correlate with maternal care received by individuals early in life
    Felisa N van Hasselt
    SILS CNS, University of Amsterdam, Amsterdam, The Netherlands
    Hippocampus 22:255-66. 2012
    ..We conclude that even moderate variations in early life environment have a major impact on adult hippocampal function. This principle could provide a mechanistic basis for individual differences in susceptibility to psychopathology...
  45. ncbi Suppressed proliferation and apoptotic changes in the rat dentate gyrus after acute and chronic stress are reversible
    Vivi M Heine
    Institute for Neurobiology, Swammerdam Institute for Life Sciences, University of Amsterdam, Kruislaan 320, 1098 SM Amsterdam, The Netherlands
    Eur J Neurosci 19:131-44. 2004
    ..This may have important implications for our understanding of the reversibility of stress-related hippocampal volume changes, such as occur, for example, in depression...
  46. ncbi Corticosterone slowly enhances miniature excitatory postsynaptic current amplitude in mice CA1 hippocampal cells
    Henk Karst
    Center for Neuroscience, Swammerdam Institute for Life Sciences, University of Amsterdam, Kruislaan 320, 1098 SM Amsterdam, The Netherlands
    J Neurophysiol 94:3479-86. 2005
    ..In summary, the present results show that activation of hippocampal glucocorticoid receptors induces a slow enhancement of AMPA-receptor-mediated responses, at the single-cell level...
  47. doi Corticosteroid effects on cellular physiology of limbic cells
    Marian Joels
    SILS CNS, University of Amsterdam, Kruislaan 320, 1098 SM Amsterdam, The Netherlands
    Brain Res 1293:91-100. 2009
    ..Finally, the time- and region-specific corticosteroid actions strongly depend on the individual's life history...
  48. ncbi Corticosteroid hormones, synaptic strength and emotional memories: corticosteroid modulation of memory -- a cellular and molecular perspective
    Olof Wiegert
    Swammerdam Institute for Life Sciences, SILS CNS, Universiteit van Amsterdam, Kruislaan 320, 1098 SM, Amsterdam, The Netherlands
    Prog Brain Res 167:269-71. 2008
    ..Based on recent findings we propose a model in which corticosterone can rapidly enhance synaptic plasticity. Later, corticosterone may stabilize synaptic efficacy, possibly at the expense of reduced synaptic plasticity...
  49. ncbi Combined β-adrenergic and corticosteroid receptor activation regulates AMPA receptor function in hippocampal neurons
    Ming Zhou
    Swammerdam Institute for Life Sciences, Center for Neuroscience, University of Amsterdam, Amsterdam, The Netherlands
    J Psychopharmacol 26:516-24. 2012
    ..These combined hormonal effects on glutamate transmission might contribute to their memory-enhancing effects...
  50. pmc Blocking mineralocorticoid receptors prior to retrieval reduces contextual fear memory in mice
    Ming Zhou
    Center for Neuroscience, Swammerdam Institute for Life Sciences, University of Amsterdam, Amsterdam, The Netherlands
    PLoS ONE 6:e26220. 2011
    ..We tested here whether blockade of MRs or GRs during retrieval also affects subsequent expression of fear memory...
  51. ncbi Gene expression patterns in rat dentate granule cells: comparison between fresh and fixed tissue
    Yongjun Qin
    Section Neurobiology, Swammerdam Institute for Life Sciences, University of Amsterdam, Kruislaan 320, 1098SM Amsterdam, The Netherlands
    J Neurosci Methods 131:205-11. 2003
    ..The present approach validates expression profiling from small amounts of fixed neurons as a powerful tool to investigate molecular processes if fresh tissue is not available...
  52. ncbi Chronic unpredictable stress impairs long-term potentiation in rat hippocampal CA1 area and dentate gyrus in vitro
    Deborah N Alfarez
    Swammerdam Institute for Life Sciences, Section Neurobiology, University of Amsterdam, The Netherlands
    Eur J Neurosci 17:1928-34. 2003
    ..It is tempting to speculate that the stress-induced reduction of hippocampal efficacy provides a cellular substrate for cognitive deficits in hippocampus-dependent learning tasks seen after prolonged exposure to stressful events...
  53. ncbi No effect of prolonged corticosterone over-exposure on NCAM, SGK1, and RGS4 mRNA expression in rat hippocampus
    Neeltje G van Gemert
    Swammerdam Institute for Life Sciences, Center for NeuroScience University of Amsterdam Kruislaan 320, 1098 SM Amsterdam, The Netherlands
    Brain Res 1093:161-6. 2006
    ..We found that the expression of none of these candidates was affected by corticosterone treatment...
  54. ncbi Maternal care and hippocampal plasticity: evidence for experience-dependent structural plasticity, altered synaptic functioning, and differential responsiveness to glucocorticoids and stress
    Danielle L Champagne
    Swammerdam Institute for Life Sciences Center for Neuroscience, University of Amsterdam, 1098 SM Amsterdam, The Netherlands
    J Neurosci 28:6037-45. 2008
    ....
  55. pmc Individual variations in maternal care early in life correlate with later life decision-making and c-fos expression in prefrontal subregions of rats
    Felisa N van Hasselt
    SILS CNS, University of Amsterdam, Amsterdam, The Netherlands
    PLoS ONE 7:e37820. 2012
    ..We conclude that natural variations in maternal care received by pups may significantly contribute to later-life decision-making and activity of underlying brain structures...
  56. doi Glucocorticoid receptor protein expression in human hippocampus; stability with age
    Qian Wang
    Swammerdam Institute for Life Sciences SILS Center for Neuroscience, University of Amsterdam, Amsterdam, The Netherlands
    Neurobiol Aging 34:1662-73. 2013
    ..Thus, in contrast to the very low levels previously reported in monkey, GR protein is prominently expressed in human hippocampus, indicating that this region can form an important target for corticosteroid effects in human...
  57. ncbi Gene expression changes in single dentate granule neurons after adrenalectomy of rats
    Yongjun Qin
    Swammerdam Institute for Life Science, Section Neurobiology, University of Amsterdam, Kruislaan 320, 1098 SM Amsterdam, The Netherlands
    Brain Res Mol Brain Res 111:17-23. 2003
    ....
  58. doi Interacting noradrenergic and corticosteroid systems shift human brain activation patterns during encoding
    Anda H van Stegeren
    University of Amsterdam, Department of Clinical Psychology, Roetersstraat 15, 1018 WB Amsterdam, The Netherlands
    Neurobiol Learn Mem 93:56-65. 2010
    ....
  59. ncbi Improved long-term potentiation and memory in young tau-P301L transgenic mice before onset of hyperphosphorylation and tauopathy
    Karin Boekhoorn
    Swammerdam Institute for Life Sciences, Center for Neuroscience, University of Amsterdam, 1098 SM Amsterdam, The Netherlands
    J Neurosci 26:3514-23. 2006
    ....
  60. ncbi Stress, depression and hippocampal apoptosis
    Paul J Lucassen
    Centre for Neuroscience, Swammerdam Institute for Life Sciences, University of Amsterdam, Amsterdam, The Netherlands
    CNS Neurol Disord Drug Targets 5:531-46. 2006
    ..Modulation of apoptosis and neurogenesis, by drugs interfering with stress components like MR and/or GR, and/or mediators of the cell death cascade, may therefore provide important drug targets for the modulation of mood and memory...
  61. doi Stress, the hippocampus, and epilepsy
    Marian Joels
    SILS CNS, University of Amsterdam, The Netherlands
    Epilepsia 50:586-97. 2009
    ..It will be interesting to examine how curtailing the effects of stress in adults, for example, by brief treatment with antiglucocorticoids, may be beneficial to the treatment of epilepsy...
  62. pmc Chronic stress effects on hippocampal structure and synaptic function: relevance for depression and normalization by anti-glucocorticoid treatment
    Harmen J Krugers
    Center for Neuroscience, Swammerdam Institute for Life Sciences, University of Amsterdam Amsterdam, Netherlands
    Front Synaptic Neurosci 2:24. 2010
    ....
  63. pmc Regulation of excitatory synapses and fearful memories by stress hormones
    Harm J Krugers
    Center for Neuroscience, Swammerdam Institute for Life Sciences, University of Amsterdam Amsterdam, Netherlands
    Front Behav Neurosci 5:62. 2011
    ..Here we will review how glucocorticoids and norepinephrine regulate the formation of fearful memories in rodents and humans and how these hormones can facilitate the storage of information by regulating excitatory synapses...
  64. pmc The neuro-symphony of stress
    Marian Joels
    SILS CNS, University of Amsterdam, The Netherlands
    Nat Rev Neurosci 10:459-66. 2009
    ..Together, this results in the stress instruments producing an orchestrated 'symphony' that enables fine-tuned responses to diverse challenges...
  65. pmc Interactions between noradrenaline and corticosteroids in the brain: from electrical activity to cognitive performance
    Harm J Krugers
    Center for Neuroscience, Swammerdam Institute for Life Sciences, University of Amsterdam, Amsterdam, Netherlands
    Front Cell Neurosci 6:15. 2012
    ....