Judith W M Jeuken

Summary

Affiliation: University Medical Centre
Country: The Netherlands

Publications

  1. ncbi request reprint Molecular pathogenesis of oligodendroglial tumors
    Judith W M Jeuken
    Department of Pathology, University Medical Centre Nijmegen, Nijmegen, The Netherlands
    J Neurooncol 70:161-81. 2004
  2. ncbi request reprint Genetic reflection of glioblastoma biopsy material in xenografts: characterization of 11 glioblastoma xenograft lines by comparative genomic hybridization
    J W Jeuken
    Department of Neurosurgery, University Hospital Nijmegen, The Netherlands
    J Neurosurg 92:652-8. 2000
  3. ncbi request reprint Comparative genomic hybridization: practical guidelines
    Judith W M Jeuken
    Department of Neurology, University Medical Center Nijmegen, The Netherlands
    Diagn Mol Pathol 11:193-203. 2002
  4. ncbi request reprint Correlation between localization, age, and chromosomal imbalances in ependymal tumours as detected by CGH
    Judith W M Jeuken
    Department of Neurology, University Medical Centre Nijmegen, P O Box 9101, 6500 HB, Nijmegen, The Netherlands
    J Pathol 197:238-44. 2002
  5. ncbi request reprint Chromosomal imbalances in primary oligodendroglial tumors and their recurrences: clues about malignant progression detected using comparative genomic hybridization
    Judith W M Jeuken
    Department of Neurology, University Medical Center Nijmegen, The Netherlands
    J Neurosurg 96:559-64. 2002
  6. ncbi request reprint Subtyping of oligo-astrocytic tumours by comparative genomic hybridization
    J W Jeuken
    Department of Neurology Neurosurgery 321, University Medical Centre St Radboud, P O Box 9101, Reinier Postlaan 4, 6500 HB Nijmegen, The Netherlands
    J Pathol 194:81-7. 2001
  7. ncbi request reprint MS-MLPA: an attractive alternative laboratory assay for robust, reliable, and semiquantitative detection of MGMT promoter hypermethylation in gliomas
    Judith W M Jeuken
    Department of Pathology, Nijmegen Center for Molecular Life Sciences, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Lab Invest 87:1055-65. 2007
  8. doi request reprint The nature and timing of specific copy number changes in the course of molecular progression in diffuse gliomas: further elucidation of their genetic "life story"
    Judith W M Jeuken
    Department of Pathology, Nijmegen Center for Molecular Life Sciences UMC St Radboud, Nijmegen, The Netherlands
    Brain Pathol 21:308-20. 2011
  9. ncbi request reprint Cyclin D1 genotype and expression in sporadic hemangioblastomas
    Johanna M M Gijtenbeek
    Department of Neurology, Radboud University, Nijmegen Medical Center, P O Box 9101, 6500 HB Nijmegen, The Netherlands
    J Neurooncol 74:261-6. 2005
  10. ncbi request reprint Six year survival after prolonged temozolomide treatment in a 30-year-old patient with glioblastoma
    Janneke Poelen
    Dept of Neurology, Canisius Wilhelmina Hospital, Nijmegen, The Netherlands
    Acta Neurol Belg 109:238-42. 2009

Collaborators

Detail Information

Publications17

  1. ncbi request reprint Molecular pathogenesis of oligodendroglial tumors
    Judith W M Jeuken
    Department of Pathology, University Medical Centre Nijmegen, Nijmegen, The Netherlands
    J Neurooncol 70:161-81. 2004
    ..Furthermore, as microarray technology is rapidly increasing, it is likely that clinically relevant markers for OTs will be identified on other chromosomes and need to be included into routine glioma diagnostics as well...
  2. ncbi request reprint Genetic reflection of glioblastoma biopsy material in xenografts: characterization of 11 glioblastoma xenograft lines by comparative genomic hybridization
    J W Jeuken
    Department of Neurosurgery, University Hospital Nijmegen, The Netherlands
    J Neurosurg 92:652-8. 2000
    ..The authors also studied genetic stability during serial passaging of three xenograft lines...
  3. ncbi request reprint Comparative genomic hybridization: practical guidelines
    Judith W M Jeuken
    Department of Neurology, University Medical Center Nijmegen, The Netherlands
    Diagn Mol Pathol 11:193-203. 2002
    ..This paper shows the complexity of the CGH technique and may serve as a guideline for starting CGH or as a troubleshooting guide for those who perform CGH...
  4. ncbi request reprint Correlation between localization, age, and chromosomal imbalances in ependymal tumours as detected by CGH
    Judith W M Jeuken
    Department of Neurology, University Medical Centre Nijmegen, P O Box 9101, 6500 HB, Nijmegen, The Netherlands
    J Pathol 197:238-44. 2002
    ..It is concluded that the genetic background of ETs is complex and partly determined by tumour site, histopathological subtype, and age of the patient...
  5. ncbi request reprint Chromosomal imbalances in primary oligodendroglial tumors and their recurrences: clues about malignant progression detected using comparative genomic hybridization
    Judith W M Jeuken
    Department of Neurology, University Medical Center Nijmegen, The Netherlands
    J Neurosurg 96:559-64. 2002
    ..The aim of the present study is the elucidation of chromosomal imbalances involved in the progression of oligodendroglial tumors toward malignancy...
  6. ncbi request reprint Subtyping of oligo-astrocytic tumours by comparative genomic hybridization
    J W Jeuken
    Department of Neurology Neurosurgery 321, University Medical Centre St Radboud, P O Box 9101, Reinier Postlaan 4, 6500 HB Nijmegen, The Netherlands
    J Pathol 194:81-7. 2001
    ....
  7. ncbi request reprint MS-MLPA: an attractive alternative laboratory assay for robust, reliable, and semiquantitative detection of MGMT promoter hypermethylation in gliomas
    Judith W M Jeuken
    Department of Pathology, Nijmegen Center for Molecular Life Sciences, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Lab Invest 87:1055-65. 2007
    ..The semiquantitative aspect of MS-MLPA may prove to be of great value, especially in predicting response to alkylating agents, not only for gliomas as evaluated in this study but also for tumors in general...
  8. doi request reprint The nature and timing of specific copy number changes in the course of molecular progression in diffuse gliomas: further elucidation of their genetic "life story"
    Judith W M Jeuken
    Department of Pathology, Nijmegen Center for Molecular Life Sciences UMC St Radboud, Nijmegen, The Netherlands
    Brain Pathol 21:308-20. 2011
    ..In conclusion, identification of molecular malignancy as proposed will aid in establishing a risk profile for individual patients and thereby in therapeutic decision making...
  9. ncbi request reprint Cyclin D1 genotype and expression in sporadic hemangioblastomas
    Johanna M M Gijtenbeek
    Department of Neurology, Radboud University, Nijmegen Medical Center, P O Box 9101, 6500 HB Nijmegen, The Netherlands
    J Neurooncol 74:261-6. 2005
    ..We conclude that, whereas variable but sometimes high cyclin D1 expression is a feature of sporadic hemangioblastomas, CCND1 genotype is unlikely to be an important genetic modifier in the oncogenesis of these tumors...
  10. ncbi request reprint Six year survival after prolonged temozolomide treatment in a 30-year-old patient with glioblastoma
    Janneke Poelen
    Dept of Neurology, Canisius Wilhelmina Hospital, Nijmegen, The Netherlands
    Acta Neurol Belg 109:238-42. 2009
    ..Up till now there are no studies describing TMZ treatment in GBM patients for as long as 6 years...
  11. doi request reprint Significance of complete 1p/19q co-deletion, IDH1 mutation and MGMT promoter methylation in gliomas: use with caution
    Sandra H E Boots-Sprenger
    Department of Pathology, Radboud University Nijmegen Medical Centre RUNMC, 6500 HB Nijmegen, The Netherlands
    Mod Pathol 26:922-9. 2013
    ..However, for individual patients the molecular information should be interpreted with caution and weighed in the context of parameters such as age and histopathological diagnosis. ..
  12. ncbi request reprint Molecular diagnostics as a tool to personalize treatment in adult glioma patients
    Judith W M Jeuken
    Department of Pathology, Nijmegen Centre for Molecular Life Sciences NCMLS, Radboud University Nijmegen, Medical Centre, Nijmegen, The Netherlands
    Technol Cancer Res Treat 5:215-29. 2006
    ..Finally, future perspectives will be presented with regard to the contribution of molecular diagnostics to tailor-made therapy in glioma patients...
  13. doi request reprint MAPK pathway activation through BRAF gene fusion in pilocytic astrocytomas; a novel oncogenic fusion gene with diagnostic, prognostic, and therapeutic potential
    Judith W M Jeuken
    Department of Pathology, Radboud University Nijmegen Medical Centre RUNMC, Nijmegen, The Netherlands
    J Pathol 222:324-8. 2010
    ....
  14. ncbi request reprint Analysis of von hippel-lindau mutations with comparative genomic hybridization in sporadic and hereditary hemangioblastomas: possible genetic heterogeneity
    Johanna M M Gijtenbeek
    Department of Neurology, University Medical Center Nijmegen, The Netherlands
    J Neurosurg 97:977-82. 2002
    ..The aim of this study was to analyze further both sporadic HBs and VHL-related HBs to determine if these histopathologically identical tumors have a different genetic background...
  15. doi request reprint Effects of targeting the VEGF and PDGF pathways in diffuse orthotopic glioma models
    Anna C Navis
    Department of Pathology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    J Pathol 223:626-34. 2011
    ..These data show that inhibition of VEGF signalling cannot be optimized by additional PDGFR inhibition and support the concept that diffuse infiltrative areas in gliomas are resistant to anti-angiogenic therapy...
  16. ncbi request reprint Chromosomal and methylation alterations in sporadic and familial adenomatous polyposis-related duodenal carcinomas
    Marloes Berkhout
    Department of Gastroenterology, Radboud University Nijmegen Medical Centre, Nijmegen, Netherlands
    Mod Pathol 20:1253-62. 2007
    ..Furthermore, hypermethylation seems to be a general feature of both FAP-related duodenal carcinomas as well as sporadic duodenal carcinomas with the exception of the PAX6 gene, which is methylated only in FAP-related carcinomas...
  17. ncbi request reprint Re: multiplex ligation dependent probe amplification for the detection of 1p and 19q loss in oligodendroglial tumors
    Judith W M Jeuken
    Brain Pathol 15:364; author reply 365. 2005