P L Jansen

Summary

Affiliation: University Hospital Groningen
Country: The Netherlands

Publications

  1. ncbi Genetic cholestasis, causes and consequences for hepatobiliary transport
    Peter L M Jansen
    Department of Gastroenterology, University Hospital Groningen, The Netherlands
    Liver Int 23:315-22. 2003
  2. ncbi Genetic cholestasis
    P L M Jansen
    Department of Gastroenterology and Department of Pediatrics, University Hospital Groningen, The Netherlands
    Dtsch Med Wochenschr 128:S107-9. 2003
  3. ncbi [Bile formation and cholestasis]
    P L Jansen
    afd Maag, Darm en Leverziekten, Academisch Ziekenhuis, Hanzeplein 1, 9713 GZ Groningen
    Ned Tijdschr Geneeskd 144:2384-91. 2000
  4. ncbi Genetic cholestasis: lessons from the molecular physiology of bile formation
    P L Jansen
    Division of Hepatology and Gastroenterology, University Hospital Groningen, Groningen, The Netherlands
    Can J Gastroenterol 14:233-8. 2000
  5. ncbi Paediatric cholestasis: is villin the villain?
    Peter L M Jansen
    Department of Pediatrics, University Hospital Groningen, 9713 GZ, Groningen, Netherlands
    Lancet 362:1090-1. 2003
  6. ncbi Diagnosis and management of Crigler-Najjar syndrome
    P L Jansen
    Division of Gastro enterology and Liver Diseases, University Hospital Groningen, Hanzeplein 1, NL 9713 GZ Groningen, The Netherlands
    Eur J Pediatr 158:S89-94. 1999
  7. ncbi Hepatocanalicular bile salt export pump deficiency in patients with progressive familial intrahepatic cholestasis
    P L Jansen
    Department of Gastroenterology, University Hospital Groningen, Groningen, The Netherlands
    Gastroenterology 117:1370-9. 1999
  8. ncbi Up-regulation of the multidrug resistance genes, Mrp1 and Mdr1b, and down-regulation of the organic anion transporter, Mrp2, and the bile salt transporter, Spgp, in endotoxemic rat liver
    T A Vos
    Groningen Institute for Drug Studies, University Center for Pharmacy, University Hospital Groningen, Groningen, The Netherlands
    Hepatology 28:1637-44. 1998
  9. ncbi Glutathione S-conjugate transport in hepatocytes entering the cell cycle is preserved by a switch in expression from the apical MRP2 to the basolateral MRP1 transporting protein
    H Roelofsen
    Dept of Internal Medicine, Div of Gastroenterology and Hepatology, University Hospital Groningen, PO Box 30001, The Netherlands
    J Cell Sci 112:1395-404. 1999
  10. ncbi Biliary fibrosis associated with altered bile composition in a mouse model of erythropoietic protoporphyria
    L Meerman
    Center for Liver, Digestive, and Metabolic Diseases, Groningen Institute for Drug Studies, Groningen, The Netherlands
    Gastroenterology 117:696-705. 1999

Collaborators

Detail Information

Publications53

  1. ncbi Genetic cholestasis, causes and consequences for hepatobiliary transport
    Peter L M Jansen
    Department of Gastroenterology, University Hospital Groningen, The Netherlands
    Liver Int 23:315-22. 2003
    ..Serum gamma-GT activity is elevated in these patients. Ursodeoxycholic acid therapy is useful for patients with a partial defect. Liver transplantation is a more definitive therapy for these patients...
  2. ncbi Genetic cholestasis
    P L M Jansen
    Department of Gastroenterology and Department of Pediatrics, University Hospital Groningen, The Netherlands
    Dtsch Med Wochenschr 128:S107-9. 2003
  3. ncbi [Bile formation and cholestasis]
    P L Jansen
    afd Maag, Darm en Leverziekten, Academisch Ziekenhuis, Hanzeplein 1, 9713 GZ Groningen
    Ned Tijdschr Geneeskd 144:2384-91. 2000
    ..These proteins also play a role in drug-induced liver disease and in primary biliary cirrhosis. Cyclosporine and oestradiol (glucuronide) for instance inhibit bile salt export protein (BSEP)...
  4. ncbi Genetic cholestasis: lessons from the molecular physiology of bile formation
    P L Jansen
    Division of Hepatology and Gastroenterology, University Hospital Groningen, Groningen, The Netherlands
    Can J Gastroenterol 14:233-8. 2000
    ..In Dubin-Johnson syndrome there is no cholestasis; only the hepatobiliary transport of conjugated bilirubin is affected. This, therefore, is a mild disease, and patients have a normal lifespan...
  5. ncbi Paediatric cholestasis: is villin the villain?
    Peter L M Jansen
    Department of Pediatrics, University Hospital Groningen, 9713 GZ, Groningen, Netherlands
    Lancet 362:1090-1. 2003
  6. ncbi Diagnosis and management of Crigler-Najjar syndrome
    P L Jansen
    Division of Gastro enterology and Liver Diseases, University Hospital Groningen, Hanzeplein 1, NL 9713 GZ Groningen, The Netherlands
    Eur J Pediatr 158:S89-94. 1999
    ..Oral calcium supplementation makes phototherapy more efficient. Gene therapy has been performed successfully in the Gunn rat, an animal model for this disease. Liver cell transplantation has recently been done in a child with CNS type 1...
  7. ncbi Hepatocanalicular bile salt export pump deficiency in patients with progressive familial intrahepatic cholestasis
    P L Jansen
    Department of Gastroenterology, University Hospital Groningen, Groningen, The Netherlands
    Gastroenterology 117:1370-9. 1999
    ..We investigated expression of the bile salt export pump (BSEP) in liver samples from patients with a PFIC phenotype and correlated this with BSEP gene mutations...
  8. ncbi Up-regulation of the multidrug resistance genes, Mrp1 and Mdr1b, and down-regulation of the organic anion transporter, Mrp2, and the bile salt transporter, Spgp, in endotoxemic rat liver
    T A Vos
    Groningen Institute for Drug Studies, University Center for Pharmacy, University Hospital Groningen, Groningen, The Netherlands
    Hepatology 28:1637-44. 1998
    ..The simultaneous up-regulation of mrp1 and mdr1b may confer resistance to hepatocytes against cytokine-induced metabolic stress...
  9. ncbi Glutathione S-conjugate transport in hepatocytes entering the cell cycle is preserved by a switch in expression from the apical MRP2 to the basolateral MRP1 transporting protein
    H Roelofsen
    Dept of Internal Medicine, Div of Gastroenterology and Hepatology, University Hospital Groningen, PO Box 30001, The Netherlands
    J Cell Sci 112:1395-404. 1999
    ..We conclude that a switch in expression from the apically located mrp2 to the basolaterally located mrp1 preserves glutathione S-conjugate transport in hepatocytes entering the cell cycle and protects against certain cytotoxic agents...
  10. ncbi Biliary fibrosis associated with altered bile composition in a mouse model of erythropoietic protoporphyria
    L Meerman
    Center for Liver, Digestive, and Metabolic Diseases, Groningen Institute for Drug Studies, Groningen, The Netherlands
    Gastroenterology 117:696-705. 1999
    ..Rather than peroxidative processes, formation of cytotoxic bile with high concentrations of bile salts and PP may cause biliary fibrosis in fch/fch mice by damaging bile duct epithelium...
  11. ncbi Long-term follow-up after liver transplantation for erythropoietic protoporphyria
    L Meerman
    Department of Gastroenterology and Hepatology, University Hospital, Groningen, The Netherlands
    Eur J Gastroenterol Hepatol 11:431-8. 1999
    ..CONCLUSIONS: The main cause of liver damage in EPP is overproduction of protoporphyrin in the bone marrow. Liver transplantation must be considered as symptomatic therapy with a high-risk for recurrent disease...
  12. pmc ATP- and glutathione-dependent transport of chemotherapeutic drugs by the multidrug resistance protein MRP1
    J Renes
    Groningen Institute for Drug Studies, Division of Gastroenterology and Hepatology, University Hospital Groningen, The Netherlands
    Br J Pharmacol 126:681-8. 1999
    ..4 microM. In conclusion, these results demonstrate that MRP1 transports vincristine and daunorubicin in an ATP- and GSH-dependent manner. APDA is not a substrate for MRP1...
  13. ncbi 3-Hydroxy-3-methylglutaryl-coenzyme A reductase inhibitors (statins) induce hepatic expression of the phospholipid translocase mdr2 in rats
    G J Hooiveld
    Groningen Institute for Drug Studies, University of Groningen, Groningen, The Netherlands
    Gastroenterology 117:678-87. 1999
    ..The aim of this study was to relate the effects of statins on bile formation to the expression of mdr2 and other hepatic adenosine triphosphate-dependent transport proteins involved in bile formation in rats...
  14. pmc Regulation of organic anion transport in the liver
    H Roelofsen
    Department of Internal Medicine, University Hospital, Groningen, The Netherlands
    Yale J Biol Med 70:435-45. 1997
    ..The cloning of the gene for cmoat opens up new possibilities to study the regulation of hepatic organic anion transport...
  15. ncbi Induction of Mdr1b expression by tumor necrosis factor-alpha in rat liver cells is independent of p53 but requires NF-kappaB signaling
    J E Ros
    Groningen University Institute for Drug Exploration GUIDE, Division of Gastroenterology and Hepatology, Department of Internal Medicine, Groningen, The Netherlands
    Hepatology 33:1425-31. 2001
    ..Mutation of the NF-kappaB site in the Mdr1b promoter prevents its induction by TNF-alpha. In conclusion our results show that activation of the rat Mdr1b gene by TNF-alpha is a result of NF-kappaB signaling and independent of p53...
  16. ncbi Persistent unconjugated hyperbilirubinemia after liver transplantation due to an abnormal bilirubin UDP-glucuronosyltransferase gene promoter sequence in the donor
    P L Jansen
    Division of Hepatology and Gastroenterology, University Hospital, Groningen, The Netherlands
    J Hepatol 27:1-5. 1997
    ..We postulate that these patients could have received a liver from a donor with the Gilbert's syndrome genotype. Therefore, we investigated the UGT1A-gene TATAA-box in DNA from liver graft donors of jaundiced and non-jaundiced recipients...
  17. ncbi Expression of nitric oxide synthases and formation of nitrotyrosine and reactive oxygen species in inflammatory bowel disease
    G Dijkstra
    Department of Gastroenterology and Hepatology, University Hospital Groningen, The Netherlands
    J Pathol 186:416-21. 1998
    ..One may speculate that NO has a protective role when during active inflammation other mucosal defence systems are impaired...
  18. ncbi Hyperlipidemia and atherosclerosis associated with liver disease in ferrochelatase-deficient mice
    V W Bloks
    Departments of Pediatrics, Center for Liver, Digestive, and Metabolic Diseases, Groningen University Institute for Drug Exploration, University Hospital Groningen, 9700 RB Groningen, The Netherlands
    J Lipid Res 42:41-50. 2001
    ..van Goor, H. Roelofsen, J. Baller, R. Havinga, H. J. Verkade, A. van Tol, P. L. M. Jansen, and F. Kuipers. Hyperlipidemia and atherosclerosis associated with liver disease in ferrochelatase-deficient mice. J. Lipid Res. 2001. 42: 41;-50...
  19. ncbi New criteria for liver transplantation in adults: the combined Groningen and Rotterdam protocol
    P L Jansen
    Division of Gastroenterology and Hepatology, University Hospital Groningen, Netherlands
    Neth J Med 52:53-7. 1998
    ..Referral to liver transplantation centres is the final step. In the Netherlands, liver disease is relatively rare and therefore patients are best served when the expertise is concentrated in a few liver centres...
  20. ncbi Hepatology in the 21st century. Gene transfer, hepatocyte transplantation, DNA chips, cyberspace and ... a friendly hospital
    P L Jansen
    Department of Gastrointestinal and Liver Diseases, University Hospital Groningen, The Netherlands
    Neth J Med 55:287-92. 1999
    ..The 21st century patient will know the way in cyberspace and will go shopping for the best doctor, for the best treatment and for the best, or friendliest, hospital...
  21. ncbi Increased cancer risk after liver transplantation: a population-based study
    E B Haagsma
    Department of Gastroenterology and Hepatology, University Hospital Groningen, The Netherlands
    J Hepatol 34:84-91. 2001
    ..Development of de novo malignancies emerges as a serious long term complication after liver transplantation...
  22. ncbi Human and rat bile acid-CoA:amino acid N-acyltransferase are liver-specific peroxisomal enzymes: implications for intracellular bile salt transport
    Antonella Pellicoro
    Department of Gastroenterology and Hepatology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    Hepatology 45:340-8. 2007
    ..Unconjugated or deconjugated bile salts returning to the liver need to shuttle through the peroxisome before reentering the enterohepatic circulation...
  23. ncbi Tauroursodeoxycholic acid protects rat hepatocytes from bile acid-induced apoptosis via activation of survival pathways
    Marieke H Schoemaker
    Center for Liver, Digestive and Metabolic Diseases, Groningen University Institute for Drug Exploration, Groningen, The Netherlands
    Hepatology 39:1563-73. 2004
    ..In conclusion, TUDCA contributes to the protection against GCDCA-induced mitochondria-controlled apoptosis by activating survival pathways...
  24. ncbi Targeting nitric oxide in the gastrointestinal tract
    Gerard Dijkstra
    Department of Gastroenterology and Hepatology, University Hospital Groningen, PO Box 30 001, 9700 RB Groningen, The Netherlands
    Curr Opin Investig Drugs 5:529-36. 2004
    ..Lumenal donation of NO could therefore block NFkappaB activation and be a treatment option in inflammatory conditions of the bowel...
  25. ncbi Synthesis and evaluation of a fluorine-18 labeled antisense oligonucleotide as a potential PET tracer for iNOS mRNA expression
    Erik F J de Vries
    PET Center, Groningen University Hospital, P O Box 30 001, 9700 RB Groningen, The Netherlands
    Nucl Med Biol 31:605-12. 2004
    ..However, neither uptake nor efflux showed any selectivity for iNOS expressing cells. The oligonucleotide showed a high level of non-specific binding, which may have obscured its specific hybridization to iNOS mRNA...
  26. ncbi Benign recurrent intrahepatic cholestasis type 2 is caused by mutations in ABCB11
    Saskia W C van Mil
    Department of Metabolic and Endocrine Diseases, University Medical Center, Utrecht, The Netherlands
    Gastroenterology 127:379-84. 2004
    ..We hypothesized that a genetically distinct form of BRIC is associated with mutations in ABCB11. This gene encodes the bile salt export pump (BSEP) and is mutated in PFIC type 2...
  27. ncbi Opposite effect of oxidative stress on inducible nitric oxide synthase and haem oxygenase-1 expression in intestinal inflammation: anti-inflammatory effect of carbon monoxide
    Gerard Dijkstra
    Department of Gastroenterology and Hepatology, University Hospital Groningen, The Netherlands
    J Pathol 204:296-303. 2004
    ..These findings suggest that iNOS (NF-kappaB driven) and HO-1 (AP-1 driven) represent mutually exclusive survival mechanisms in intestinal epithelial cells...
  28. ncbi Rapid increase of bile salt secretion is associated with bile duct injury after human liver transplantation
    Erwin Geuken
    Section of Hepatobiliary Surgery and Liver Transplantation, Department of Surgery, University Hospital Groningen, P O Box 30 001, 9700 RB Groningen, The Netherlands
    J Hepatol 41:1017-25. 2004
    ..Biliary strictures are a serious cause of morbidity after liver transplantation. We have studied the role of altered bile composition as a mechanism of bile duct injury after human liver transplantation...
  29. ncbi Superoxide anions and hydrogen peroxide induce hepatocyte death by different mechanisms: involvement of JNK and ERK MAP kinases
    Laura Conde de la Rosa
    Center for Liver, Digestive and Metabolic Diseases, University Medical Center Groningen, Groningen, P O 30 001, 9700 RB, The Netherlands
    J Hepatol 44:918-29. 2006
    ..Apoptosis was determined by measuring caspase-9, -6, -3 activation and cleaved PARP, and necrotic cell death by Sytox Green staining...
  30. ncbi Absence of association between the multidrug resistance (MDR1) gene and inflammatory bowel disease
    Liekele E Oostenbrug
    Department of Gastroenterology and Hepatology, University Medical Center Groningen, University of Groningen, The Netherlands
    Scand J Gastroenterol 41:1174-82. 2006
    ..The purpose of this study was to examine the involvement of this gene in IBD in a large population of Dutch patients with IBD and family-based controls...
  31. ncbi Decreased P-glycoprotein (P-gp/MDR1) expression in inflamed human intestinal epithelium is independent of PXR protein levels
    Hans Blokzijl
    Department of Gastroenterology and Hepatology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    Inflamm Bowel Dis 13:710-20. 2007
    ..Here we compared intestinal MDR1 mRNA and protein expression in uninflamed and inflamed intestinal epithelium (IE) of patients with gastrointestinal inflammatory disorders to healthy controls...
  32. pmc Stereoselective transport of hydrophilic quaternary drugs by human MDR1 and rat Mdr1b P-glycoproteins
    Guido J E J Hooiveld
    Groningen University Institute for Drug Exploration, Division of Gastroenterology and Hepatology, University Hospital Groningen, Hanzeplein 1, NL 9713 GZ, Groningen, The Netherlands
    Br J Pharmacol 135:1685-94. 2002
    ....
  33. ncbi A progressive familial intrahepatic cholestasis type 2 mutation causes an unstable, temperature-sensitive bile salt export pump
    Jacqueline R M Plass
    Department of Gastroenterology and Hepatology, Center for Liver, Digestive and Metabolic Diseases, University Hospital Groningen, PO Box 30 001, 9700 RB Groningen, The Netherlands
    J Hepatol 40:24-30. 2004
    ..The disease is caused by mutations in the bile salt export pump (BSEP). Ten different missense mutations have been described. In this study, we analysed the effect of the D482G PFIC-2 mutation on BSEP function...
  34. ncbi High expression of MDR1, MRP1, and MRP3 in the hepatic progenitor cell compartment and hepatocytes in severe human liver disease
    Jenny E Ros
    Center for the Study of Liver, Digestive and Metabolic Diseases, Groningen University Institute for Drug Exploration GUIDE, University Hospital Groningen, Groningen, The Netherlands
    J Pathol 200:553-60. 2003
    ..In conclusion, MDR1, MRP1, and MRP3 are up-regulated in hepatocytes in severe human liver disease. Strong MDR1, MRP1, and MRP3 reactivity is seen in regenerating human bile ductules...
  35. ncbi Cytokine regulation of pro- and anti-apoptotic genes in rat hepatocytes: NF-kappaB-regulated inhibitor of apoptosis protein 2 (cIAP2) prevents apoptosis
    Marieke H Schoemaker
    Center for Liver, Digestive and Metabolic Diseases, University Hospital Groningen, PO Box 30 001, 9700 RB, Groningen, The Netherlands
    J Hepatol 36:742-50. 2002
    ..In the present study the relationship between NF-kappaB activation and apoptosis has been investigated in hepatocytes...
  36. ncbi Resistance of rat hepatocytes against bile acid-induced apoptosis in cholestatic liver injury is due to nuclear factor-kappa B activation
    Marieke H Schoemaker
    Center for Liver, Digestive and Metabolic Diseases, Groningen, The Netherlands
    J Hepatol 39:153-61. 2003
    ..To examine the extent and mechanisms of apoptosis in cholestatic liver injury and to explore the role of the transcription factor nuclear factor-kappa B in protection against bile acid-induced apoptosis...
  37. ncbi Mdr P-glycoproteins are not essential for biliary excretion of the hydrophobic heme precursor protoporphyrin in a griseofulvin-induced mouse model of erythropoietic protoporphyria
    Torsten Plosch
    Center for Liver, Digestive, and Metabolic Diseases, Groningen University Institute for Drug Exploration, Departments of Pediatrics and Gastroenterology, University Hospital Groningen, Groningen, The Netherlands
    Hepatology 35:299-306. 2002
    ..In conclusion, the data show that Mdr P-glycoproteins are not critically involved in biliary removal of excess PP and indicate that the presence of biliary lipids is required for formation of intrahepatic PP deposits...
  38. ncbi Phenobarbital alters hepatic Mrp2 function by direct and indirect interactions
    Nita J Patel
    Division of Drug Delivery and Disposition, School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA
    Mol Pharmacol 64:154-9. 2003
    ....
  39. ncbi Induction of hepatic ABC transporter expression is part of the PPARalpha-mediated fasting response in the mouse
    Tineke Kok
    Center for Liver, Digestive and Metabolic Diseases, Laboratory of Pediatrics, CMC IV, Room Y2 163, Groningen University Institute for Drug Exploration, Academic Hospital Groningen, Hanzeplein 1, 9713 GZ Groningen, The Netherlands
    Gastroenterology 124:160-71. 2003
    ..We tested whether fasting-associated fatty acid release from adipose tissues alters hepatic transporter expression and bile formation in a PPARalpha-dependent manner...
  40. pmc Peroxisome proliferator-activated receptor alpha (PPARalpha)-mediated regulation of multidrug resistance 2 (Mdr2) expression and function in mice
    Tineke Kok
    Groningen University Institute for Drug Exploration, Center for Liver, Digestive and Metabolic Diseases, Laboratory of Pediatrics, University Hospital Groningen, The Netherlands
    Biochem J 369:539-47. 2003
    ..The induction of Mdr2 mRNA and Mdr2 protein levels by fibrates is mediated by PPARalpha, while the induction of Mdr1a / 1b in vivo probably reflects a secondary phenomenon related to chronic PPARalpha activation...
  41. ncbi Low-level HCV viraemia after initial response during antiviral therapy: transcription-mediated amplification predicts treatment failure
    Huub C Gelderblom
    Section of Clinical Virology, Department of Medical Microbiology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Antivir Ther 12:423-7. 2007
    ..We studied this phenomenon in subsets of patients...
  42. ncbi Monocyte-derived dendritic cells from chronic HCV patients are not infected but show an immature phenotype and aberrant cytokine profile
    Huub C Gelderblom
    Department of Gastroenterology and Hepatology, AMC Liver Center, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Liver Int 27:944-53. 2007
    ..Therefore, we studied the presence of HCV RNA in monocytes and monocyte-derived DCs from chronic HCV patients...
  43. doi Carbon monoxide blocks oxidative stress-induced hepatocyte apoptosis via inhibition of the p54 JNK isoform
    Laura Conde de la Rosa
    Center for Liver, Digestive and Metabolic Diseases, University Medical Center Groningen, 9700 RB Groningen, The Netherlands
    Free Radic Biol Med 44:1323-33. 2008
    ..We conclude that HO-1 and CO protect primary hepatocytes against superoxide-anions-induced apoptosis partially via inhibition of JNK activity. CO could represent an important candidate for the treatment of liver diseases...
  44. doi PDGF-receptor beta-targeted adenovirus redirects gene transfer from hepatocytes to activated stellate cells
    Marieke H Schoemaker
    Department of Gastroenterology and Hepatology, University of Groningen and University Medical Center Groningen, Groningen, The Netherlands
    Mol Pharm 5:399-406. 2008
    ..Our novel approach demonstrates that therapeutic genes can be selectively directed to stellate cells. This opens new possibilities for the treatment of liver fibrosis...
  45. ncbi Farnesoid X receptor and bile salts are involved in transcriptional regulation of the gene encoding the human bile salt export pump
    Jacqueline R M Plass
    Center for Liver, Digestive, and Metabolic Diseases, University Hospital Groningen, 9700 RB Groningen, The Netherlands
    Hepatology 35:589-96. 2002
    ..In conclusion, these results show that FXR is required for the bile salt-dependent transcriptional control of the human ABCB11 gene and that the cellular amount of FXR is critical for the level of activation of ABCB11 transcription...
  46. ncbi Liver disease in the elderly
    Peter L M Jansen
    Department of Hepatology and Gastroenterology, University Hospital Groningen, The Netherlands
    Best Pract Res Clin Gastroenterol 16:149-58. 2002
    ..There is a high prevalence of gallstones among old people, in particular among females. For symptomatic choledocholithiasis in elderly patients, endoscopic bile duct clearance does not necessarily need to be followed by cholecystectomy...
  47. ncbi Clinical outcome of Crohn's disease according to the Vienna classification: disease location is a useful predictor of disease course
    Liekele E Oostenbrug
    Department of Gastroenterology and Hepatology, University Medical Center Groningen, University of Groningen, The Netherlands
    Eur J Gastroenterol Hepatol 18:255-61. 2006
    ..The aim of this study was to determine the usefulness of the Vienna classification in patient care and clinical studies...
  48. ncbi Association between Toll-like receptor 4 and inflammatory bowel disease
    Liekele E Oostenbrug
    Department of Gastroenterology and Hepatology, University of Groningen Medical Center, Groningen, The Netherlands
    Inflamm Bowel Dis 11:567-75. 2005
    ..As such, there is a potentially important role of TLR4 in the pathogenesis of inflammatory bowel disease (IBD). We studied the involvement of TLR4 in IBD in a large population of Dutch patients with IBD and in family-based controls...
  49. ncbi Bile acids induce hepatic stellate cell proliferation via activation of the epidermal growth factor receptor
    Gianluca Svegliati-Baroni
    Department of Gastroenterology, University of Ancona, Italy
    Gastroenterology 128:1042-55. 2005
    ..The aim of this study was to investigate the effects of bile acids on HSC proliferation...
  50. ncbi Drug transport proteins in the liver
    Klaas Nico Faber
    Department of Gastroenterology and Hepatology, State University Groningen, Hanzeplein 1, 9713 GZ Groningen, The Netherlands
    Adv Drug Deliv Rev 55:107-24. 2003
    ..Adverse drug reactions may be caused by genetic or disease-induced variations of transporter expression or drug-drug interactions at the level of these transporters...
  51. ncbi Relative contributions of NOS isoforms during experimental colitis: endothelial-derived NOS maintains mucosal integrity
    Bruce A Vallance
    Division of Gastroenterology, British Columbia s Children s Hospital, Vancouver, British Columbia, V6H 3V4
    Am J Physiol Gastrointest Liver Physiol 287:G865-74. 2004
    ..These results identify a protective role for both iNOS and eNOS during colitis, with eNOS deficiency resulting in impaired intestinal defense against lumenal bacteria and increased susceptibility to colitis...
  52. ncbi Immunoglobulin coating of faecal bacteria in inflammatory bowel disease
    Laurens A van der Waaij
    Department of Internal Medicine Gastroenterology Section, University of Groningen, Groningen, The Netherlands
    Eur J Gastroenterol Hepatol 16:669-74. 2004
    ..In this study we determined the percentage of immunoglobulin-coated bacteria in the stools of patients and controls...
  53. doi Prediction of virologic response in difficult-to-treat chronic hepatitis C patients during high-dose interferon induction therapy
    Huub C Gelderblom
    AMC Liver Center, Department of Gastroenterology and Hepatology
    Scand J Gastroenterol 43:857-69. 2008
    ....