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Genomes and Genes | P L JansenSummaryAffiliation: University Hospital Groningen Country: The Netherlands Publications
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Publications
Genetic cholestasis, causes and consequences for hepatobiliary transportPeter L M Jansen
Department of Gastroenterology, University Hospital Groningen, The Netherlands
Liver Int 23:315-22. 2003..Serum gamma-GT activity is elevated in these patients. Ursodeoxycholic acid therapy is useful for patients with a partial defect. Liver transplantation is a more definitive therapy for these patients...- Genetic cholestasisP L M Jansen
Department of Gastroenterology and Department of Pediatrics, University Hospital Groningen, The Netherlands
Dtsch Med Wochenschr 128:S107-9. 2003 - [Bile formation and cholestasis]P L Jansen
afd Maag, Darm en Leverziekten, Academisch Ziekenhuis, Hanzeplein 1, 9713 GZ Groningen
Ned Tijdschr Geneeskd 144:2384-91. 2000..These proteins also play a role in drug-induced liver disease and in primary biliary cirrhosis. Cyclosporine and oestradiol (glucuronide) for instance inhibit bile salt export protein (BSEP)... - Genetic cholestasis: lessons from the molecular physiology of bile formationP L Jansen
Division of Hepatology and Gastroenterology, University Hospital Groningen, Groningen, The Netherlands
Can J Gastroenterol 14:233-8. 2000..In Dubin-Johnson syndrome there is no cholestasis; only the hepatobiliary transport of conjugated bilirubin is affected. This, therefore, is a mild disease, and patients have a normal lifespan... - Paediatric cholestasis: is villin the villain?Peter L M Jansen
Department of Pediatrics, University Hospital Groningen, 9713 GZ, Groningen, Netherlands
Lancet 362:1090-1. 2003 - Diagnosis and management of Crigler-Najjar syndromeP L Jansen
Division of Gastro enterology and Liver Diseases, University Hospital Groningen, Hanzeplein 1, NL 9713 GZ Groningen, The Netherlands
Eur J Pediatr 158:S89-94. 1999..Oral calcium supplementation makes phototherapy more efficient. Gene therapy has been performed successfully in the Gunn rat, an animal model for this disease. Liver cell transplantation has recently been done in a child with CNS type 1... - Hepatocanalicular bile salt export pump deficiency in patients with progressive familial intrahepatic cholestasisP L Jansen
Department of Gastroenterology, University Hospital Groningen, Groningen, The Netherlands
Gastroenterology 117:1370-9. 1999..We investigated expression of the bile salt export pump (BSEP) in liver samples from patients with a PFIC phenotype and correlated this with BSEP gene mutations... - Up-regulation of the multidrug resistance genes, Mrp1 and Mdr1b, and down-regulation of the organic anion transporter, Mrp2, and the bile salt transporter, Spgp, in endotoxemic rat liverT A Vos
Groningen Institute for Drug Studies, University Center for Pharmacy, University Hospital Groningen, Groningen, The Netherlands
Hepatology 28:1637-44. 1998..The simultaneous up-regulation of mrp1 and mdr1b may confer resistance to hepatocytes against cytokine-induced metabolic stress... - Glutathione S-conjugate transport in hepatocytes entering the cell cycle is preserved by a switch in expression from the apical MRP2 to the basolateral MRP1 transporting proteinH Roelofsen
Dept of Internal Medicine, Div of Gastroenterology and Hepatology, University Hospital Groningen, PO Box 30001, The Netherlands
J Cell Sci 112:1395-404. 1999..We conclude that a switch in expression from the apically located mrp2 to the basolaterally located mrp1 preserves glutathione S-conjugate transport in hepatocytes entering the cell cycle and protects against certain cytotoxic agents... - Biliary fibrosis associated with altered bile composition in a mouse model of erythropoietic protoporphyriaL Meerman
Center for Liver, Digestive, and Metabolic Diseases, Groningen Institute for Drug Studies, Groningen, The Netherlands
Gastroenterology 117:696-705. 1999..Rather than peroxidative processes, formation of cytotoxic bile with high concentrations of bile salts and PP may cause biliary fibrosis in fch/fch mice by damaging bile duct epithelium... - Long-term follow-up after liver transplantation for erythropoietic protoporphyriaL Meerman
Department of Gastroenterology and Hepatology, University Hospital, Groningen, The Netherlands
Eur J Gastroenterol Hepatol 11:431-8. 1999..CONCLUSIONS: The main cause of liver damage in EPP is overproduction of protoporphyrin in the bone marrow. Liver transplantation must be considered as symptomatic therapy with a high-risk for recurrent disease... 
ATP- and glutathione-dependent transport of chemotherapeutic drugs by the multidrug resistance protein MRP1J Renes
Groningen Institute for Drug Studies, Division of Gastroenterology and Hepatology, University Hospital Groningen, The Netherlands
Br J Pharmacol 126:681-8. 1999..4 microM. In conclusion, these results demonstrate that MRP1 transports vincristine and daunorubicin in an ATP- and GSH-dependent manner. APDA is not a substrate for MRP1...- 3-Hydroxy-3-methylglutaryl-coenzyme A reductase inhibitors (statins) induce hepatic expression of the phospholipid translocase mdr2 in ratsG J Hooiveld
Groningen Institute for Drug Studies, University of Groningen, Groningen, The Netherlands
Gastroenterology 117:678-87. 1999..The aim of this study was to relate the effects of statins on bile formation to the expression of mdr2 and other hepatic adenosine triphosphate-dependent transport proteins involved in bile formation in rats... - Regulation of organic anion transport in the liverH Roelofsen
Department of Internal Medicine, University Hospital, Groningen, The Netherlands
Yale J Biol Med 70:435-45. 1997..The cloning of the gene for cmoat opens up new possibilities to study the regulation of hepatic organic anion transport... - Induction of Mdr1b expression by tumor necrosis factor-alpha in rat liver cells is independent of p53 but requires NF-kappaB signalingJ E Ros
Groningen University Institute for Drug Exploration GUIDE, Division of Gastroenterology and Hepatology, Department of Internal Medicine, Groningen, The Netherlands
Hepatology 33:1425-31. 2001..Mutation of the NF-kappaB site in the Mdr1b promoter prevents its induction by TNF-alpha. In conclusion our results show that activation of the rat Mdr1b gene by TNF-alpha is a result of NF-kappaB signaling and independent of p53... - Persistent unconjugated hyperbilirubinemia after liver transplantation due to an abnormal bilirubin UDP-glucuronosyltransferase gene promoter sequence in the donorP L Jansen
Division of Hepatology and Gastroenterology, University Hospital, Groningen, The Netherlands
J Hepatol 27:1-5. 1997..We postulate that these patients could have received a liver from a donor with the Gilbert's syndrome genotype. Therefore, we investigated the UGT1A-gene TATAA-box in DNA from liver graft donors of jaundiced and non-jaundiced recipients... - Expression of nitric oxide synthases and formation of nitrotyrosine and reactive oxygen species in inflammatory bowel diseaseG Dijkstra
Department of Gastroenterology and Hepatology, University Hospital Groningen, The Netherlands
J Pathol 186:416-21. 1998..One may speculate that NO has a protective role when during active inflammation other mucosal defence systems are impaired... - Hyperlipidemia and atherosclerosis associated with liver disease in ferrochelatase-deficient miceV W Bloks
Departments of Pediatrics, Center for Liver, Digestive, and Metabolic Diseases, Groningen University Institute for Drug Exploration, University Hospital Groningen, 9700 RB Groningen, The Netherlands
J Lipid Res 42:41-50. 2001..van Goor, H. Roelofsen, J. Baller, R. Havinga, H. J. Verkade, A. van Tol, P. L. M. Jansen, and F. Kuipers. Hyperlipidemia and atherosclerosis associated with liver disease in ferrochelatase-deficient mice. J. Lipid Res. 2001. 42: 41;-50... - New criteria for liver transplantation in adults: the combined Groningen and Rotterdam protocolP L Jansen
Division of Gastroenterology and Hepatology, University Hospital Groningen, Netherlands
Neth J Med 52:53-7. 1998..Referral to liver transplantation centres is the final step. In the Netherlands, liver disease is relatively rare and therefore patients are best served when the expertise is concentrated in a few liver centres... - Hepatology in the 21st century. Gene transfer, hepatocyte transplantation, DNA chips, cyberspace and ... a friendly hospitalP L Jansen
Department of Gastrointestinal and Liver Diseases, University Hospital Groningen, The Netherlands
Neth J Med 55:287-92. 1999..The 21st century patient will know the way in cyberspace and will go shopping for the best doctor, for the best treatment and for the best, or friendliest, hospital... - Increased cancer risk after liver transplantation: a population-based studyE B Haagsma
Department of Gastroenterology and Hepatology, University Hospital Groningen, The Netherlands
J Hepatol 34:84-91. 2001..Development of de novo malignancies emerges as a serious long term complication after liver transplantation... - Human and rat bile acid-CoA:amino acid N-acyltransferase are liver-specific peroxisomal enzymes: implications for intracellular bile salt transportAntonella Pellicoro
Department of Gastroenterology and Hepatology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
Hepatology 45:340-8. 2007..Unconjugated or deconjugated bile salts returning to the liver need to shuttle through the peroxisome before reentering the enterohepatic circulation... - Tauroursodeoxycholic acid protects rat hepatocytes from bile acid-induced apoptosis via activation of survival pathwaysMarieke H Schoemaker
Center for Liver, Digestive and Metabolic Diseases, Groningen University Institute for Drug Exploration, Groningen, The Netherlands
Hepatology 39:1563-73. 2004..In conclusion, TUDCA contributes to the protection against GCDCA-induced mitochondria-controlled apoptosis by activating survival pathways... - Targeting nitric oxide in the gastrointestinal tractGerard Dijkstra
Department of Gastroenterology and Hepatology, University Hospital Groningen, PO Box 30 001, 9700 RB Groningen, The Netherlands
Curr Opin Investig Drugs 5:529-36. 2004..Lumenal donation of NO could therefore block NFkappaB activation and be a treatment option in inflammatory conditions of the bowel... - Synthesis and evaluation of a fluorine-18 labeled antisense oligonucleotide as a potential PET tracer for iNOS mRNA expressionErik F J de Vries
PET Center, Groningen University Hospital, P O Box 30 001, 9700 RB Groningen, The Netherlands
Nucl Med Biol 31:605-12. 2004..However, neither uptake nor efflux showed any selectivity for iNOS expressing cells. The oligonucleotide showed a high level of non-specific binding, which may have obscured its specific hybridization to iNOS mRNA... - Benign recurrent intrahepatic cholestasis type 2 is caused by mutations in ABCB11Saskia W C van Mil
Department of Metabolic and Endocrine Diseases, University Medical Center, Utrecht, The Netherlands
Gastroenterology 127:379-84. 2004..We hypothesized that a genetically distinct form of BRIC is associated with mutations in ABCB11. This gene encodes the bile salt export pump (BSEP) and is mutated in PFIC type 2... - Opposite effect of oxidative stress on inducible nitric oxide synthase and haem oxygenase-1 expression in intestinal inflammation: anti-inflammatory effect of carbon monoxideGerard Dijkstra
Department of Gastroenterology and Hepatology, University Hospital Groningen, The Netherlands
J Pathol 204:296-303. 2004..These findings suggest that iNOS (NF-kappaB driven) and HO-1 (AP-1 driven) represent mutually exclusive survival mechanisms in intestinal epithelial cells... - Rapid increase of bile salt secretion is associated with bile duct injury after human liver transplantationErwin Geuken
Section of Hepatobiliary Surgery and Liver Transplantation, Department of Surgery, University Hospital Groningen, P.O. Box 30.001, 9700 RB Groningen, The Netherlands
J Hepatol 41:1017-25. 2004..This results in cytotoxic bile formation and correlates with bile duct injury. These findings suggest that endogenous bile salts have a role in the pathogenesis of bile duct injury after liver transplantation... - Superoxide anions and hydrogen peroxide induce hepatocyte death by different mechanisms: involvement of JNK and ERK MAP kinasesLaura Conde de la Rosa
Center for Liver, Digestive and Metabolic Diseases, University Medical Center Groningen, Groningen, P.O. 30.001, 9700 RB, The Netherlands
J Hepatol 44:918-29. 2006..CONCLUSIONS: In normal hepatocytes, superoxide anions-induced caspase activation and apoptosis is dependent on JNK activity and totally abolished by superoxide scavengers... - Absence of association between the multidrug resistance (MDR1) gene and inflammatory bowel diseaseLiekele E Oostenbrug
Department of Gastroenterology and Hepatology, University Medical Center Groningen, University of Groningen, The Netherlands
Scand J Gastroenterol 41:1174-82. 2006..The purpose of this study was to examine the involvement of this gene in IBD in a large population of Dutch patients with IBD and family-based controls... - Decreased P-glycoprotein (P-gp/MDR1) expression in inflamed human intestinal epithelium is independent of PXR protein levelsHans Blokzijl
Department of Gastroenterology and Hepatology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
Inflamm Bowel Dis 13:710-20. 2007..Here we compared intestinal MDR1 mRNA and protein expression in uninflamed and inflamed intestinal epithelium (IE) of patients with gastrointestinal inflammatory disorders to healthy controls... - Stereoselective transport of hydrophilic quaternary drugs by human MDR1 and rat Mdr1b P-glycoproteinsGuido J E J Hooiveld
Groningen University Institute for Drug Exploration, Division of Gastroenterology and Hepatology, University Hospital Groningen, Hanzeplein 1, NL 9713 GZ, Groningen, The Netherlands
Br J Pharmacol 135:1685-94. 2002.... - A progressive familial intrahepatic cholestasis type 2 mutation causes an unstable, temperature-sensitive bile salt export pumpJacqueline R M Plass
Department of Gastroenterology and Hepatology, Center for Liver, Digestive and Metabolic Diseases, University Hospital Groningen, PO Box 30 001, 9700 RB Groningen, The Netherlands
J Hepatol 40:24-30. 2004..The disease is caused by mutations in the bile salt export pump (BSEP). Ten different missense mutations have been described. In this study, we analysed the effect of the D482G PFIC-2 mutation on BSEP function... - High expression of MDR1, MRP1, and MRP3 in the hepatic progenitor cell compartment and hepatocytes in severe human liver diseaseJenny E Ros
Center for the Study of Liver, Digestive and Metabolic Diseases, Groningen University Institute for Drug Exploration (GUIDE, University Hospital Groningen, Groningen, The Netherlands
J Pathol 200:553-60. 2003..In conclusion, MDR1, MRP1, and MRP3 are up-regulated in hepatocytes in severe human liver disease. Strong MDR1, MRP1, and MRP3 reactivity is seen in regenerating human bile ductules... - Cytokine regulation of pro- and anti-apoptotic genes in rat hepatocytes: NF-kappaB-regulated inhibitor of apoptosis protein 2 (cIAP2) prevents apoptosisMarieke H Schoemaker
Center for Liver, Digestive and Metabolic Diseases, University Hospital Groningen, PO Box 30 001, 9700 RB, Groningen, The Netherlands
J Hepatol 36:742-50. 2002..In the present study the relationship between NF-kappaB activation and apoptosis has been investigated in hepatocytes... - Resistance of rat hepatocytes against bile acid-induced apoptosis in cholestatic liver injury is due to nuclear factor-kappa B activationMarieke H Schoemaker
Center for Liver, Digestive and Metabolic Diseases, Groningen, The Netherlands
J Hepatol 39:153-61. 2003..To examine the extent and mechanisms of apoptosis in cholestatic liver injury and to explore the role of the transcription factor nuclear factor-kappa B in protection against bile acid-induced apoptosis... - Mdr P-glycoproteins are not essential for biliary excretion of the hydrophobic heme precursor protoporphyrin in a griseofulvin-induced mouse model of erythropoietic protoporphyriaTorsten Plosch
Center for Liver, Digestive, and Metabolic Diseases, Groningen University Institute for Drug Exploration, Departments of Pediatrics and Gastroenterology, University Hospital Groningen, Groningen, The Netherlands
Hepatology 35:299-306. 2002..In conclusion, the data show that Mdr P-glycoproteins are not critically involved in biliary removal of excess PP and indicate that the presence of biliary lipids is required for formation of intrahepatic PP deposits... - Phenobarbital alters hepatic Mrp2 function by direct and indirect interactionsNita J Patel
Division of Drug Delivery and Disposition, School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA
Mol Pharmacol 64:154-9. 2003.... - Induction of hepatic ABC transporter expression is part of the PPARalpha-mediated fasting response in the mouseTineke Kok
Center for Liver, Digestive and Metabolic Diseases, Laboratory of Pediatrics, CMC IV, Room Y2 163, Groningen University Institute for Drug Exploration, Academic Hospital Groningen, Hanzeplein 1, 9713 GZ Groningen, The Netherlands
Gastroenterology 124:160-71. 2003..We tested whether fasting-associated fatty acid release from adipose tissues alters hepatic transporter expression and bile formation in a PPARalpha-dependent manner... - Peroxisome proliferator-activated receptor alpha (PPARalpha)-mediated regulation of multidrug resistance 2 (Mdr2) expression and function in miceTineke Kok
Groningen University Institute for Drug Exploration, Center for Liver, Digestive and Metabolic Diseases, Laboratory of Pediatrics, University Hospital Groningen, The Netherlands
Biochem J 369:539-47. 2003..The induction of Mdr2 mRNA and Mdr2 protein levels by fibrates is mediated by PPARalpha, while the induction of Mdr1a / 1b in vivo probably reflects a secondary phenomenon related to chronic PPARalpha activation... - Low-level HCV viraemia after initial response during antiviral therapy: transcription-mediated amplification predicts treatment failureHuub C Gelderblom
Section of Clinical Virology, Department of Medical Microbiology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
Antivir Ther 12:423-7. 2007..We studied this phenomenon in subsets of patients... - Monocyte-derived dendritic cells from chronic HCV patients are not infected but show an immature phenotype and aberrant cytokine profileHuub C Gelderblom
Department of Gastroenterology and Hepatology, AMC Liver Center, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
Liver Int 27:944-53. 2007..Therefore, we studied the presence of HCV RNA in monocytes and monocyte-derived DCs from chronic HCV patients... 
Carbon monoxide blocks oxidative stress-induced hepatocyte apoptosis via inhibition of the p54 JNK isoformLaura Conde de la Rosa
Center for Liver, Digestive and Metabolic Diseases, University Medical Center Groningen, 9700 RB Groningen, The Netherlands
Free Radic Biol Med 44:1323-33. 2008..We conclude that HO-1 and CO protect primary hepatocytes against superoxide-anions-induced apoptosis partially via inhibition of JNK activity. CO could represent an important candidate for the treatment of liver diseases...- PDGF-receptor beta-targeted adenovirus redirects gene transfer from hepatocytes to activated stellate cellsMarieke H Schoemaker
Department of Gastroenterology and Hepatology, University of Groningen and University Medical Center Groningen, Groningen, The Netherlands
Mol Pharm 5:399-406. 2008..Our novel approach demonstrates that therapeutic genes can be selectively directed to stellate cells. This opens new possibilities for the treatment of liver fibrosis... - Farnesoid X receptor and bile salts are involved in transcriptional regulation of the gene encoding the human bile salt export pumpJacqueline R M Plass
Center for Liver, Digestive, and Metabolic Diseases, University Hospital Groningen, 9700 RB Groningen, The Netherlands
Hepatology 35:589-96. 2002..In conclusion, these results show that FXR is required for the bile salt-dependent transcriptional control of the human ABCB11 gene and that the cellular amount of FXR is critical for the level of activation of ABCB11 transcription... - Liver disease in the elderlyPeter L M Jansen
Department of Hepatology and Gastroenterology, University Hospital Groningen, The Netherlands
Best Pract Res Clin Gastroenterol 16:149-58. 2002..There is a high prevalence of gallstones among old people, in particular among females. For symptomatic choledocholithiasis in elderly patients, endoscopic bile duct clearance does not necessarily need to be followed by cholecystectomy... - Clinical outcome of Crohn's disease according to the Vienna classification: disease location is a useful predictor of disease courseLiekele E Oostenbrug
Department of Gastroenterology and Hepatology, University Medical Center Groningen, University of Groningen, The Netherlands
Eur J Gastroenterol Hepatol 18:255-61. 2006..The aim of this study was to determine the usefulness of the Vienna classification in patient care and clinical studies... - Association between Toll-like receptor 4 and inflammatory bowel diseaseLiekele E Oostenbrug
Department of Gastroenterology and Hepatology, University of Groningen Medical Center, Groningen, The Netherlands
Inflamm Bowel Dis 11:567-75. 2005..As such, there is a potentially important role of TLR4 in the pathogenesis of inflammatory bowel disease (IBD). We studied the involvement of TLR4 in IBD in a large population of Dutch patients with IBD and in family-based controls... - Bile acids induce hepatic stellate cell proliferation via activation of the epidermal growth factor receptorGianluca Svegliati-Baroni
Department of Gastroenterology, University of Ancona, Italy
Gastroenterology 128:1042-55. 2005..Bile acids induce HSC proliferation via the activation of the epidermal growth factor receptor, whereas HSCs are protected against bile acid-induced apoptosis by excluding bile acids... - Drug transport proteins in the liverKlaas Nico Faber
Department of Gastroenterology and Hepatology, State University Groningen, Hanzeplein 1, 9713 GZ Groningen, The Netherlands
Adv Drug Deliv Rev 55:107-24. 2003..Adverse drug reactions may be caused by genetic or disease-induced variations of transporter expression or drug-drug interactions at the level of these transporters... - Relative contributions of NOS isoforms during experimental colitis: endothelial-derived NOS maintains mucosal integrityBruce A Vallance
Division of Gastroenterology, British Columbia s Children s Hospital, Vancouver, British Columbia, V6H 3V4
Am J Physiol Gastrointest Liver Physiol 287:G865-74. 2004..These results identify a protective role for both iNOS and eNOS during colitis, with eNOS deficiency resulting in impaired intestinal defense against lumenal bacteria and increased susceptibility to colitis... - Immunoglobulin coating of faecal bacteria in inflammatory bowel diseaseLaurens A van der Waaij
Department of Internal Medicine Gastroenterology Section, University of Groningen, Groningen, The Netherlands
Eur J Gastroenterol Hepatol 16:669-74. 2004..In this study we determined the percentage of immunoglobulin-coated bacteria in the stools of patients and controls... - Prediction of virologic response in difficult-to-treat chronic hepatitis C patients during high-dose interferon induction therapyHuub C Gelderblom
AMC Liver Center, Department of Gastroenterology and Hepatology
Scand J Gastroenterol 43:857-69. 2008....