Affiliation: University Medical Center Groningen
Country: The Netherlands
- Dose-response characteristics of ketamine effect on locomotion, cognitive function and central neuronal activityGabor Imre
Department of Psychiatry, P7 16, Medical Center, University of Groningen, Hanzeplein 1, P O Box 30 001, 9700 RB Groningen, The Netherlands
Brain Res Bull 69:338-45. 2006..C-fos expression indicated that the dose-dependent behavioral effects of ketamine might be related to changes in the activity of limbic regions, notably hippocampus and amygdala...
- Effects of the mGluR2/3 agonist LY379268 on ketamine-evoked behaviours and neurochemical changes in the dentate gyrus of the ratGabor Imre
Department of Psychiatry, University Medical Center Groningen, and University of Groningen, The Netherlands
Pharmacol Biochem Behav 84:392-9. 2006..Additional work is needed to address a possible role of LY379268 in schizophrenia and anxiety treatment...
- Subchronic administration of LY354740 does not modify ketamine-evoked behavior and neuronal activity in ratsGabor Imre
Department of Psychiatry, University Medical Center Groningen, P7 16, University of Groningen, Hanzeplein 1, PO Box 30 001, 9700 RB Groningen, The Netherlands
Eur J Pharmacol 544:77-81. 2006..At all doses, LY354740 failed to reverse both behavioral and neuronal effects of the ketamine. These results therefore do not support the putative antipsychotic role of LY354740...
- The preclinical properties of a novel group II metabotropic glutamate receptor agonist LY379268Gabor Imre
Department of Behavioral Pharmacology, Gedeon Richter Ltd, Budapest, Hungary
CNS Drug Rev 13:444-64. 2007..To date, no clinical data with LY379268 are available. This review article summarizes the preclinical pharmacology of LY379268...