H E Hulshoff Pol

Summary

Affiliation: University Medical Center Utrecht
Country: The Netherlands

Publications

  1. ncbi request reprint Prenatal exposure to famine and brain morphology in schizophrenia
    H E Hulshoff Pol
    Department of Psychiatry, University Medical Center Utrecht, The Netherlands
    Am J Psychiatry 157:1170-2. 2000
  2. ncbi request reprint Odor discrimination in patients with frontal lobe damage and Korsakoff's syndrome
    Hilleke E Hulshoff Pol
    Department of Psychiatry A01 126, University Medical Center Utrecht, Heidelberglaan 100, 3584 CX Utrecht, The Netherlands
    Neuropsychologia 40:888-91. 2002
  3. ncbi request reprint Genetic contributions to human brain morphology and intelligence
    Hilleke E Hulshoff Pol
    Department of Psychiatry, Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, 3584 CX Utrecht, The Netherlands
    J Neurosci 26:10235-42. 2006
  4. ncbi request reprint Twin-singleton differences in brain structure using structural equation modelling
    H E Hulshoff Pol
    Department of Psychiatry, University Medical Centre, Utrecht, The Netherlands
    Brain 125:384-90. 2002
  5. doi request reprint Brain volume reductions in medication-naive patients with schizophrenia in relation to intelligence quotient
    M Rais
    Rudolf Magnus Institute of Neuroscience, Department of Psychiatry, University Medical Center Utrecht, Utrecht, The Netherlands
    Psychol Med 42:1847-56. 2012
  6. ncbi request reprint Volumes of brain structures in twins discordant for schizophrenia
    W F Baaré
    Department of Psychiatry, University Medical Center Utrecht, Heidelberglaan 100, 3584 CX Utrecht, The Netherlands
    Arch Gen Psychiatry 58:33-40. 2001
  7. doi request reprint Is there change in intelligence quotient in chronically ill schizophrenia patients? A longitudinal study in twins discordant for schizophrenia
    A M Hedman
    Rudolf Magnus Institute of Neuroscience, Department of Psychiatry, University Medical Center Utrecht, The Netherlands
    Psychol Med 42:2535-41. 2012
  8. doi request reprint Cigarette smoking and progressive brain volume loss in schizophrenia
    N E M Van Haren
    Rudolf Magnus Institute of Neuroscience, Department of Psychiatry, University Medical Centre Utrecht, The Netherlands
    Eur Neuropsychopharmacol 20:454-8. 2010
  9. doi request reprint Symptom dimensions are associated with progressive brain volume changes in schizophrenia
    G Collin
    University Medical Center Utrecht, Department of Psychiatry, Heidelberglaan 100, 3584 CX Utrecht, The Netherlands
    Schizophr Res 138:171-6. 2012
  10. ncbi request reprint Neuropsychological dysfunctions in siblings discordant for schizophrenia
    W G Staal
    Department of Psychiatry, University of Utrecht, Heidelberglaan 100, 3584 CX, Utrecht, The Netherlands
    Psychiatry Res 95:227-35. 2000

Collaborators

Detail Information

Publications51

  1. ncbi request reprint Prenatal exposure to famine and brain morphology in schizophrenia
    H E Hulshoff Pol
    Department of Psychiatry, University Medical Center Utrecht, The Netherlands
    Am J Psychiatry 157:1170-2. 2000
    ..The authors assessed the effects of nutritional deficiency during the first trimester of pregnancy on brain morphology in patients with schizophrenia...
  2. ncbi request reprint Odor discrimination in patients with frontal lobe damage and Korsakoff's syndrome
    Hilleke E Hulshoff Pol
    Department of Psychiatry A01 126, University Medical Center Utrecht, Heidelberglaan 100, 3584 CX Utrecht, The Netherlands
    Neuropsychologia 40:888-91. 2002
    ..No deficits were found in odor detection ability. The findings suggest that in human odor discrimination, there is more involvement of cortico-cortical pathways than of thalamo-cortical pathways...
  3. ncbi request reprint Genetic contributions to human brain morphology and intelligence
    Hilleke E Hulshoff Pol
    Department of Psychiatry, Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, 3584 CX Utrecht, The Netherlands
    J Neurosci 26:10235-42. 2006
    ..35). These findings point to a neural network that shares a common genetic origin with human intelligence...
  4. ncbi request reprint Twin-singleton differences in brain structure using structural equation modelling
    H E Hulshoff Pol
    Department of Psychiatry, University Medical Centre, Utrecht, The Netherlands
    Brain 125:384-90. 2002
    ..Since other brain volume measures were comparable between the groups, twin studies can provide reliable estimates of heritabilities in brain volume measures and these can be generalized to the singleton population...
  5. doi request reprint Brain volume reductions in medication-naive patients with schizophrenia in relation to intelligence quotient
    M Rais
    Rudolf Magnus Institute of Neuroscience, Department of Psychiatry, University Medical Center Utrecht, Utrecht, The Netherlands
    Psychol Med 42:1847-56. 2012
    ..Whether these changes are dependent on medication use or related to intelligence quotient (IQ) is still debated...
  6. ncbi request reprint Volumes of brain structures in twins discordant for schizophrenia
    W F Baaré
    Department of Psychiatry, University Medical Center Utrecht, Heidelberglaan 100, 3584 CX Utrecht, The Netherlands
    Arch Gen Psychiatry 58:33-40. 2001
    ..The study was designed to examine the relative contributions of genetic and nongenetic factors to structural brain abnormalities in schizophrenia and subjects at risk to develop the disorder...
  7. doi request reprint Is there change in intelligence quotient in chronically ill schizophrenia patients? A longitudinal study in twins discordant for schizophrenia
    A M Hedman
    Rudolf Magnus Institute of Neuroscience, Department of Psychiatry, University Medical Center Utrecht, The Netherlands
    Psychol Med 42:2535-41. 2012
    ..These intellectual deficits have been found to be heritable. However, whether the intellectual deficits change over time and, if so, whether the change is related with an increased genetic risk for the disease are not known...
  8. doi request reprint Cigarette smoking and progressive brain volume loss in schizophrenia
    N E M Van Haren
    Rudolf Magnus Institute of Neuroscience, Department of Psychiatry, University Medical Centre Utrecht, The Netherlands
    Eur Neuropsychopharmacol 20:454-8. 2010
    ..Moreover, smoking was not associated with brain volume change over time in the healthy subjects. However, extremely heavy smoking may contribute to excessive gray matter volume loss in schizophrenia...
  9. doi request reprint Symptom dimensions are associated with progressive brain volume changes in schizophrenia
    G Collin
    University Medical Center Utrecht, Department of Psychiatry, Heidelberglaan 100, 3584 CX Utrecht, The Netherlands
    Schizophr Res 138:171-6. 2012
    ..e. negative, positive, disorganization, mania and depression)...
  10. ncbi request reprint Neuropsychological dysfunctions in siblings discordant for schizophrenia
    W G Staal
    Department of Psychiatry, University of Utrecht, Heidelberglaan 100, 3584 CX, Utrecht, The Netherlands
    Psychiatry Res 95:227-35. 2000
    ..These results suggest that the cognitive abnormalities in schizophrenia that may be related to genotype are represented in the domain of executive functioning and to some extent in the domain of sensory-motor functioning...
  11. doi request reprint Longitudinal study of hormonal and physical development in young twins
    M M G Koenis
    MSc, Department of Psychiatry, A01 126, University Medical Center Utrecht, Heidelberglaan 100, 3584 CX Utrecht, The Netherlands
    J Clin Endocrinol Metab 98:E518-27. 2013
    ..These correlations are largely due to genes that are involved in both early pubertal hormone levels and subsequent physical development...
  12. ncbi request reprint Differentiating between low and high susceptibility to schizophrenia in twins: the significance of dermatoglyphic indices in relation to other determinants of brain development
    C J van Oel
    Department of Psychiatry, University Medical Center Heidelberglaan 100, 3584 CX Utrecht, Netherlands
    Schizophr Res 52:181-93. 2001
    ..Fluctuating asymmetry of the finger ridges was as important as whole brain and left hippocampal volumes in differentiating twins with a high susceptibility to schizophrenia from those with a low susceptibility...
  13. doi request reprint Genetic influences on thinning of the cerebral cortex during development
    I L C van Soelen
    Rudolf Magnus Institute of Neuroscience, Department of Psychiatry, University Medical Center Utrecht, Postbus 85500, 3508 GA Utrecht, The Netherlands
    Neuroimage 59:3871-80. 2012
    ....
  14. doi request reprint Psychosis and brain volume changes during the first five years of schizophrenia
    W Cahn
    Rudolf Magnus Institute of Neuroscience, Department of Psychiatry, University Medical Center Utrecht, Utrecht, The Netherlands
    Eur Neuropsychopharmacol 19:147-51. 2009
    ..These findings strongly suggest that psychosis contributes to brain volume reductions found in schizophrenia...
  15. ncbi request reprint Structural brain abnormalities in chronic schizophrenia at the extremes of the outcome spectrum
    W G Staal
    Department of Psychiatry, University Hospital Utrecht, The Netherlands
    Am J Psychiatry 158:1140-2. 2001
    ..This study investigated the relationship between outcome and structural brain abnormalities in schizophrenia...
  16. doi request reprint Microstructural alterations of the arcuate fasciculus in schizophrenia patients with frequent auditory verbal hallucinations
    A D de Weijer
    Rudolf Magnus Institute of Neuroscience, Dept of Psychiatry, University Medical Center Utrecht, The Netherlands
    Schizophr Res 130:68-77. 2011
    ..This suggests that disintegrated fiber integrity in the connection between frontal and temporo-parietal language areas in the schizophrenia patients is associated with their liability for auditory verbal hallucinations...
  17. doi request reprint Schizophrenia as a progressive brain disease
    N E M Van Haren
    Rudolf Magnus Institute of Neuroscience, Department of Psychiatry, University Medical Centre Utrecht, Heidelberglaan 100, Utrecht, The Netherlands
    Eur Psychiatry 23:245-54. 2008
    ..One of the main challenges for the coming years, however, will be the search for gene-by-environment interactions on the progressive brain changes in schizophrenia...
  18. ncbi request reprint Quantitative genetic modeling of variation in human brain morphology
    W F Baaré
    Department of Psychiatry, University Medical Center Utrecht, The Netherlands
    Cereb Cortex 11:816-24. 2001
    ..The high heritability estimates that were found indicate that brain volumes may be useful as intermediate phenotypes in behavioral genetic research...
  19. doi request reprint The course of brain abnormalities in schizophrenia: can we slow the progression?
    N E van Haren
    Rudolf Magnus Institute of Neuroscience, Department of Psychiatry, University Medical Centre Utrecht, Utrecht, The Netherlands
    J Psychopharmacol 26:8-14. 2012
    ..Before being able to intervene with therapies and prevent the brain from shrinking, one has to understand the underlying mechanism of the progressive changes in the brains of schizophrenia patients...
  20. ncbi request reprint Brain volume changes in the first year of illness and 5-year outcome of schizophrenia
    W Cahn
    Department of Psychiatry, University Medical Center Utrecht, Heidelberglaan 100, 3584 GX Utrecht, The Netherlands
    Br J Psychiatry 189:381-2. 2006
    ..These findings suggest that early dynamic brain volume changes are related to the disease process and predict the longer-term outcome of schizophrenia...
  21. ncbi request reprint Focal gray matter density changes in schizophrenia
    H E Hulshoff Pol
    Department of Psychiatry, A01 126 University Medical Center, Utrecht, 3584 CX Utrecht, The Netherlands
    Arch Gen Psychiatry 58:1118-25. 2001
    ..However, it is unknown whether the (progressive) loss of tissue affects the brain globally or whether tissue loss is more prominent in some areas than in others...
  22. pmc White matter development in early puberty: a longitudinal volumetric and diffusion tensor imaging twin study
    Rachel M Brouwer
    Department of Psychiatry, Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, Utrecht, The Netherlands
    PLoS ONE 7:e32316. 2012
    ..In children who showed the most pronounced white matter growth, fractional anisotropy increased the least and vice-versa. Thus, white matter development in childhood may reflect a process of both expansion and fiber optimization...
  23. ncbi request reprint Odor discrimination and task duration in young and older adults
    H E Hulshoff Pol
    Departments of Psychiatry, University Medical Center Utrecht, The Netherlands
    Chem Senses 25:461-4. 2000
    ..In conclusion, task duration should be taken into consideration as a factor influencing odor discrimination in aging...
  24. ncbi request reprint Anatomical MRI of the developing human brain: what have we learned?
    S Durston
    Department of Child and Adolescent Psychiatry, University Medical Center Utrecht, The Netherlands
    J Am Acad Child Adolesc Psychiatry 40:1012-20. 2001
    ..To critically review and integrate the existing literature on magnetic resonance imaging (MRI) studies of the normally developing brain in childhood and adolescence and discuss the implications for clinical MRI studies...
  25. ncbi request reprint Differential effects of DRD4 and DAT1 genotype on fronto-striatal gray matter volumes in a sample of subjects with attention deficit hyperactivity disorder, their unaffected siblings, and controls
    S Durston
    Department of Child and Adolescent Psychiatry, Rudolf Magnus Institute for Neuroscience, University Medical Center Utrecht, Utrecht, The Netherlands
    Mol Psychiatry 10:678-85. 2005
    ....
  26. ncbi request reprint Effects of context on judgements of odor intensities in humans
    H E Hulshoff Pol
    Department of Psychiatry, University Hospital Utrecht, The Netherlands
    Chem Senses 23:131-5. 1998
    ..The findings are discussed in the light of two alternative explanations, namely, a central implicit memory process and a stimulus-level-based change at the peripheral level...
  27. doi request reprint A meta-analysis of the polyunsaturated fatty acid composition of erythrocyte membranes in schizophrenia
    W J M van der Kemp
    Image Sciences Institute, Department of Radiology, University Medical Center Utrecht, The Netherlands, P O Box 85500, 3508 GA Utrecht, The Netherlands
    Schizophr Res 141:153-61. 2012
    ..Therefore PUFA may be involved in the excessive brain tissue loss reported in schizophrenia...
  28. ncbi request reprint Brain morphology in antipsychotic-naïve schizophrenia: a study of multiple brain structures
    W Cahn
    Department of Psychiatry, University Medical Centre Utrecht, Heidelberglaan 100, 3584 CX Utrecht, The Netherlands
    Br J Psychiatry Suppl 43:s66-72. 2002
    ..Although brain volume changes are found in schizophrenia, only a limited number of structural magnetic resonance imaging studies have exclusively examined antipsychotic-naïve patients...
  29. doi request reprint Hypothalamus volume in twin pairs discordant for schizophrenia
    P Cédric M P Koolschijn
    Rudolf Magnus Institute for Neuroscience, Department of Psychiatry, University Medical Center Utrecht, Utrecht, The Netherlands
    Eur Neuropsychopharmacol 18:312-5. 2008
    ..Higher within-twin pair similarities in monozygotic compared to dizygotic twin pairs, suggests that hypothalamus volume might be partly genetically controlled...
  30. ncbi request reprint Genetic correlations between brain volumes and the WAIS-III dimensions of verbal comprehension, working memory, perceptual organization, and processing speed
    Danielle Posthuma
    Department of Biological Psychology, Vrije Universiteit, Van der Boechorststraat 1, 1081 BT Amsterdam, The Netherlands
    Twin Res 6:131-9. 2003
    ..e., do genes influence brain volume which in turn influences intelligence, or alternatively, do genes influence intelligence which in turn influences brain volume), or the presence or absence of pleiotropy has not been resolved yet...
  31. ncbi request reprint Brain volume changes in first-episode schizophrenia: a 1-year follow-up study
    Wiepke Cahn
    Department of Psychiatry, University Medical Center Utrecht, Heidelberglaan 100, 3584 CX Utrecht, The Netherlands
    Arch Gen Psychiatry 59:1002-10. 2002
    ..One would expect global gray matter to decrease progressively, particularly in first-episode patients, because clinical deterioration is greatest in the early stages of the disease...
  32. ncbi request reprint Volume changes in gray matter in patients with schizophrenia
    Hilleke E Hulshoff Pol
    Department of Psychiatry, University Medical Center Utrecht, The Netherlands
    Am J Psychiatry 159:244-50. 2002
    ..Although structural brain abnormalities, particularly decrements in gray matter volume, are considered important to the pathology of schizophrenia, it is not resolved whether the brain abnormalities become more prominent over time...
  33. ncbi request reprint Global intellectual impairment does not accelerate with age in patients with schizophrenia: a cross-sectional analysis
    Ron Hijman
    Department of Psychiatry, Rudolf Magnus Institute of Neuroscience, University Medical Center, Utrecht, The Netherlands
    Schizophr Bull 29:509-17. 2003
    ..The results confirm that there is global intellectual impairment in schizophrenia patients at the onset of illness but no age-accelerated decline and are consistent with the neurodevelopmental hypothesis of schizophrenia...
  34. ncbi request reprint Gray and white matter volume abnormalities in monozygotic and same-gender dizygotic twins discordant for schizophrenia
    Hilleke E Hulshoff Pol
    Rudolf Magnus Institute for Neuroscience, Department of Psychiatry, University Medical Center Utrecht, Utrecht, The Netherlands
    Biol Psychiatry 55:126-30. 2004
    ....
  35. ncbi request reprint Focal gray matter changes in schizophrenia across the course of the illness: a 5-year follow-up study
    Neeltje E M van Haren
    Department of Psychiatry, Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, Utrecht, The Netherlands
    Neuropsychopharmacology 32:2057-66. 2007
    ..Moreover, the progression in left frontal density loss appears to be related to an increased number of psychotic episodes, with atypical antipsychotic medication attenuating these changes...
  36. pmc Hippocampal volume and subcortical white matter lesions in late life depression: comparison of early and late onset depression
    Joost Janssen
    Medical Imaging Laboratory, Hospital Gregorio Maranon, Madrid, Spain
    J Neurol Neurosurg Psychiatry 78:638-40. 2007
    ..Therefore, we wished to investigate the relationship between age of first depression onset and hippocampal volume, with adjustment for subcortical white matter lesions...
  37. ncbi request reprint Magnetic resonance imaging of boys with attention-deficit/hyperactivity disorder and their unaffected siblings
    Sarah Durston
    Rudolf Magnus Institute of Neuroscience, Department of Psychiatry, University Medical Center Utrecht, Utrecht, The Netherlands
    J Am Acad Child Adolesc Psychiatry 43:332-40. 2004
    ..To study the influence of increased familial risk for attention-deficit/hyperactivity disorder (ADHD) on brain morphology...
  38. ncbi request reprint Reliability of brain volumes from multicenter MRI acquisition: a calibration study
    Hugo G Schnack
    Rudolf Magnus Institute of Neuroscience, Department of Psychiatry, University Medical Center Utrecht, Utrecht, The Netherlands
    Hum Brain Mapp 22:312-20. 2004
    ..84 for gray matter, and > or = 0.78 for white matter volume. Calibration of segmentation procedures allows morphologic MRI data acquired at different research sites to be combined reliably in multicenter studies...
  39. ncbi request reprint A controlled study of brain structure in monozygotic twins concordant and discordant for schizophrenia
    Neeltje E M van Haren
    Department of Psychiatry, Rudolf Magnus Institute of Neuroscience, University Medical Centre Utrecht, Utrecht, The Netherlands
    Biol Psychiatry 56:454-61. 2004
    ..We examined monozygotic twins concordant and discordant for schizophrenia to clarify the role of genetic and environmental factors in determining brain abnormalities...
  40. ncbi request reprint Hippocampal changes and white matter lesions in early-onset depression
    Joost Janssen
    Rudolf Magnus Institute of Neuroscience, University Medical Center Utrechtz, The Netherlands
    Biol Psychiatry 56:825-31. 2004
    ..We aimed to examine whether total number of subcortical white matter lesions were associated with reduced hippocampal volume in aged female subjects with early-onset depression (< 45 years) and healthy comparison subjects...
  41. ncbi request reprint Larger brains in medication naive high-functioning subjects with pervasive developmental disorder
    Saskia J M C Palmen
    Department of Child and Adolescent Psychiatry, Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, Utrecht, The Netherlands
    J Autism Dev Disord 34:603-13. 2004
    ....
  42. ncbi request reprint Association of depression duration with reduction of global cerebral gray matter volume in female patients with recurrent major depressive disorder
    Indrag K Lampe
    Rudolph Magnus Institute of Neuroscience, Department of Psychiatry, University Medical Center Utrecht, PO Box 85500, 3508 GA Utrecht, The Netherlands
    Am J Psychiatry 160:2052-4. 2003
    ..The authors investigated the relationship between depression duration and cerebral gray matter volume in female patients with recurrent major depressive disorder...
  43. ncbi request reprint Associations between alcohol intake and brain volumes in male and female moderate drinkers
    Eveline A de Bruin
    Department of Psychopharmacology, Utrecht Institute of Pharmaceutical Sciences, Utrecht University, Utrecht, The Netherlands
    Alcohol Clin Exp Res 29:656-63. 2005
    ..The authors investigated whether current or lifetime alcohol intake is related to volumes of total brain, cerebellum, ventricles, peripheral cerebrospinal fluid, and cerebral gray and white matter in moderate drinkers...
  44. ncbi request reprint Increased gray-matter volume in medication-naive high-functioning children with autism spectrum disorder
    Saskia J M C Palmen
    Department of Child and Adolescent Psychiatry, Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, Utrecht, The Netherlands
    Psychol Med 35:561-70. 2005
    ....
  45. ncbi request reprint Brain anatomy in non-affected parents of autistic probands: a MRI study
    Saskia J M C Palmen
    Department of Child and Adolescent Psychiatry, Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, Utrecht, The Netherlands
    Psychol Med 35:1411-20. 2005
    ..Identifying structural brain abnormalities under genetic control is of particular importance as these could represent endophenotypes of autism...
  46. ncbi request reprint Gray and white matter density changes in monozygotic and same-sex dizygotic twins discordant for schizophrenia using voxel-based morphometry
    Hilleke E Hulshoff Pol
    Rudolf Magnus Institute for Neuroscience, Department of Psychiatry, University Medical Center Utrecht, A01 126, Heidelberglaan 100, 3584 CX Utrecht, The Netherlands
    Neuroimage 31:482-8. 2006
    ..Focal changes in the left anterior hemisphere may therefore be particularly relevant as endophenotype in genetic studies of schizophrenia...
  47. ncbi request reprint Brain volumes as predictor of outcome in recent-onset schizophrenia: a multi-center MRI study
    Neeltje E M van Haren
    Department of Psychiatry A 01 126, University Medical Center Utrecht, 3584 CX Utrecht, The Netherlands
    Schizophr Res 64:41-52. 2003
    ..No significant correlations were found between the brain volume measures and any of these measures. Gray matter volume at illness onset does not predict outcome after 2 years in recent-onset schizophrenia...
  48. ncbi request reprint Focal brain matter differences associated with lifetime alcohol intake and visual attention in male but not in female non-alcohol-dependent drinkers
    Eveline A de Bruin
    Department of Psychopharmacology, Utrecht Institute of Pharmaceutical Sciences, Utrecht University, The Netherlands
    Neuroimage 26:536-45. 2005
    ..As the confounding effects of genetic factors were reduced, the present results may selectively relate to the effects of alcohol intake on focal brain matter...
  49. ncbi request reprint MRI, volumetry, 1H spectroscopy, and cerebropetal blood flowmetry in childhood idiopathic anatomic megalencephaly
    Suzanne M Koudijs
    Department of Child Neurology, University Medical Centre Utrecht, Utrecht, The Netherlands
    J Magn Reson Imaging 24:282-7. 2006
    ..To evaluate cerebral abnormalities in childhood idiopathic anatomic megalencephaly (MC) by means of different magnetic resonance (MR) modalities...
  50. ncbi request reprint Genetic influences on human brain structure: a review of brain imaging studies in twins
    Jiska S Peper
    Department of Psychiatry, Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, A01 126, 3584 CX Utrecht, The Netherlands
    Hum Brain Mapp 28:464-73. 2007
    ..New techniques such as genome-wide scans may become helpful in the search for genes that are involved in the regulation of human brain volume throughout life...
  51. pmc What happens after the first episode? A review of progressive brain changes in chronically ill patients with schizophrenia
    Hilleke E Hulshoff Pol
    Rudolf Magnus Institute of Neuroscience, Department of Psychiatry, University Medical Center Utrecht, Heidelberglaan 100, 3584 CX Utrecht, The Netherlands
    Schizophr Bull 34:354-66. 2008
    ..The progressive brain changes present in chronic schizophrenia may represent a continuous pathophysiological process taking place in the brains of these patients that warrants further study...