H E Hulshoff Pol

Summary

Affiliation: University Medical Center
Country: The Netherlands

Publications

  1. ncbi request reprint Effects of context on judgements of odor intensities in humans
    H E Hulshoff Pol
    Department of Psychiatry, University Hospital Utrecht, The Netherlands
    Chem Senses 23:131-5. 1998
  2. ncbi request reprint Volume changes in gray matter in patients with schizophrenia
    Hilleke E Hulshoff Pol
    Department of Psychiatry, University Medical Center Utrecht, The Netherlands
    Am J Psychiatry 159:244-50. 2002
  3. ncbi request reprint Focal gray matter density changes in schizophrenia
    H E Hulshoff Pol
    Department of Psychiatry, A01 126 University Medical Center, Utrecht, 3584 CX Utrecht, The Netherlands
    Arch Gen Psychiatry 58:1118-25. 2001
  4. ncbi request reprint Focal white matter density changes in schizophrenia: reduced inter-hemispheric connectivity
    Hilleke E Hulshoff Pol
    Neuroscience Division, A01 126, University Medical Center Utrecht, 3584 CX, Utrecht, The Netherlands
    Neuroimage 21:27-35. 2004
  5. ncbi request reprint Odor discrimination and task duration in young and older adults
    H E Hulshoff Pol
    Departments of Psychiatry, University Medical Center Utrecht, The Netherlands
    Chem Senses 25:461-4. 2000
  6. doi request reprint Brain volume reductions in medication-naive patients with schizophrenia in relation to intelligence quotient
    M Rais
    Rudolf Magnus Institute of Neuroscience, Department of Psychiatry, University Medical Center Utrecht, Utrecht, The Netherlands
    Psychol Med 42:1847-56. 2012
  7. ncbi request reprint Volumes of brain structures in twins discordant for schizophrenia
    W F Baaré
    Department of Psychiatry, University Medical Center Utrecht, Heidelberglaan 100, 3584 CX Utrecht, The Netherlands
    Arch Gen Psychiatry 58:33-40. 2001
  8. doi request reprint Cigarette smoking and progressive brain volume loss in schizophrenia
    N E M Van Haren
    Rudolf Magnus Institute of Neuroscience, Department of Psychiatry, University Medical Centre Utrecht, The Netherlands
    Eur Neuropsychopharmacol 20:454-8. 2010
  9. doi request reprint Is there change in intelligence quotient in chronically ill schizophrenia patients? A longitudinal study in twins discordant for schizophrenia
    A M Hedman
    Rudolf Magnus Institute of Neuroscience, Department of Psychiatry, University Medical Center Utrecht, The Netherlands
    Psychol Med 42:2535-41. 2012
  10. ncbi request reprint Neuropsychological dysfunctions in siblings discordant for schizophrenia
    W G Staal
    Department of Psychiatry, University of Utrecht, Heidelberglaan 100, 3584 CX, Utrecht, The Netherlands
    Psychiatry Res 95:227-35. 2000

Collaborators

Detail Information

Publications30

  1. ncbi request reprint Effects of context on judgements of odor intensities in humans
    H E Hulshoff Pol
    Department of Psychiatry, University Hospital Utrecht, The Netherlands
    Chem Senses 23:131-5. 1998
    ..The findings are discussed in the light of two alternative explanations, namely, a central implicit memory process and a stimulus-level-based change at the peripheral level...
  2. ncbi request reprint Volume changes in gray matter in patients with schizophrenia
    Hilleke E Hulshoff Pol
    Department of Psychiatry, University Medical Center Utrecht, The Netherlands
    Am J Psychiatry 159:244-50. 2002
    ..Although structural brain abnormalities, particularly decrements in gray matter volume, are considered important to the pathology of schizophrenia, it is not resolved whether the brain abnormalities become more prominent over time...
  3. ncbi request reprint Focal gray matter density changes in schizophrenia
    H E Hulshoff Pol
    Department of Psychiatry, A01 126 University Medical Center, Utrecht, 3584 CX Utrecht, The Netherlands
    Arch Gen Psychiatry 58:1118-25. 2001
    ..However, it is unknown whether the (progressive) loss of tissue affects the brain globally or whether tissue loss is more prominent in some areas than in others...
  4. ncbi request reprint Focal white matter density changes in schizophrenia: reduced inter-hemispheric connectivity
    Hilleke E Hulshoff Pol
    Neuroscience Division, A01 126, University Medical Center Utrecht, 3584 CX, Utrecht, The Netherlands
    Neuroimage 21:27-35. 2004
    ..These findings suggest aberrant inter-hemispheric connectivity of anterior cortical and sub-cortical brain regions in schizophrenia, reflecting decreased hemispheric specialisation in schizophrenia...
  5. ncbi request reprint Odor discrimination and task duration in young and older adults
    H E Hulshoff Pol
    Departments of Psychiatry, University Medical Center Utrecht, The Netherlands
    Chem Senses 25:461-4. 2000
    ..In conclusion, task duration should be taken into consideration as a factor influencing odor discrimination in aging...
  6. doi request reprint Brain volume reductions in medication-naive patients with schizophrenia in relation to intelligence quotient
    M Rais
    Rudolf Magnus Institute of Neuroscience, Department of Psychiatry, University Medical Center Utrecht, Utrecht, The Netherlands
    Psychol Med 42:1847-56. 2012
    ..Whether these changes are dependent on medication use or related to intelligence quotient (IQ) is still debated...
  7. ncbi request reprint Volumes of brain structures in twins discordant for schizophrenia
    W F Baaré
    Department of Psychiatry, University Medical Center Utrecht, Heidelberglaan 100, 3584 CX Utrecht, The Netherlands
    Arch Gen Psychiatry 58:33-40. 2001
    ..The study was designed to examine the relative contributions of genetic and nongenetic factors to structural brain abnormalities in schizophrenia and subjects at risk to develop the disorder...
  8. doi request reprint Cigarette smoking and progressive brain volume loss in schizophrenia
    N E M Van Haren
    Rudolf Magnus Institute of Neuroscience, Department of Psychiatry, University Medical Centre Utrecht, The Netherlands
    Eur Neuropsychopharmacol 20:454-8. 2010
    ..Moreover, smoking was not associated with brain volume change over time in the healthy subjects. However, extremely heavy smoking may contribute to excessive gray matter volume loss in schizophrenia...
  9. doi request reprint Is there change in intelligence quotient in chronically ill schizophrenia patients? A longitudinal study in twins discordant for schizophrenia
    A M Hedman
    Rudolf Magnus Institute of Neuroscience, Department of Psychiatry, University Medical Center Utrecht, The Netherlands
    Psychol Med 42:2535-41. 2012
    ..These intellectual deficits have been found to be heritable. However, whether the intellectual deficits change over time and, if so, whether the change is related with an increased genetic risk for the disease are not known...
  10. ncbi request reprint Neuropsychological dysfunctions in siblings discordant for schizophrenia
    W G Staal
    Department of Psychiatry, University of Utrecht, Heidelberglaan 100, 3584 CX, Utrecht, The Netherlands
    Psychiatry Res 95:227-35. 2000
    ..These results suggest that the cognitive abnormalities in schizophrenia that may be related to genotype are represented in the domain of executive functioning and to some extent in the domain of sensory-motor functioning...
  11. doi request reprint Genetic influences on thinning of the cerebral cortex during development
    I L C van Soelen
    Rudolf Magnus Institute of Neuroscience, Department of Psychiatry, University Medical Center Utrecht, Postbus 85500, 3508 GA Utrecht, The Netherlands
    Neuroimage 59:3871-80. 2012
    ....
  12. doi request reprint Symptom dimensions are associated with progressive brain volume changes in schizophrenia
    G Collin
    University Medical Center Utrecht, Department of Psychiatry, Heidelberglaan 100, 3584 CX Utrecht, The Netherlands
    Schizophr Res 138:171-6. 2012
    ..e. negative, positive, disorganization, mania and depression)...
  13. ncbi request reprint Structural brain abnormalities in chronic schizophrenia at the extremes of the outcome spectrum
    W G Staal
    Department of Psychiatry, University Hospital Utrecht, The Netherlands
    Am J Psychiatry 158:1140-2. 2001
    ..This study investigated the relationship between outcome and structural brain abnormalities in schizophrenia...
  14. doi request reprint Schizophrenia as a progressive brain disease
    N E M Van Haren
    Rudolf Magnus Institute of Neuroscience, Department of Psychiatry, University Medical Centre Utrecht, Heidelberglaan 100, Utrecht, The Netherlands
    Eur Psychiatry 23:245-54. 2008
    ..One of the main challenges for the coming years, however, will be the search for gene-by-environment interactions on the progressive brain changes in schizophrenia...
  15. doi request reprint Microstructural alterations of the arcuate fasciculus in schizophrenia patients with frequent auditory verbal hallucinations
    A D de Weijer
    Rudolf Magnus Institute of Neuroscience, Dept of Psychiatry, University Medical Center Utrecht, The Netherlands
    Schizophr Res 130:68-77. 2011
    ..This suggests that disintegrated fiber integrity in the connection between frontal and temporo-parietal language areas in the schizophrenia patients is associated with their liability for auditory verbal hallucinations...
  16. doi request reprint Longitudinal study of hormonal and physical development in young twins
    M M G Koenis
    MSc, Department of Psychiatry, A01 126, University Medical Center Utrecht, Heidelberglaan 100, 3584 CX Utrecht, The Netherlands
    J Clin Endocrinol Metab 98:E518-27. 2013
    ..These correlations are largely due to genes that are involved in both early pubertal hormone levels and subsequent physical development...
  17. doi request reprint Psychosis and brain volume changes during the first five years of schizophrenia
    W Cahn
    Rudolf Magnus Institute of Neuroscience, Department of Psychiatry, University Medical Center Utrecht, Utrecht, The Netherlands
    Eur Neuropsychopharmacol 19:147-51. 2009
    ..These findings strongly suggest that psychosis contributes to brain volume reductions found in schizophrenia...
  18. ncbi request reprint Differentiating between low and high susceptibility to schizophrenia in twins: the significance of dermatoglyphic indices in relation to other determinants of brain development
    C J van Oel
    Department of Psychiatry, University Medical Center Heidelberglaan 100, 3584 CX Utrecht, Netherlands
    Schizophr Res 52:181-93. 2001
    ..Fluctuating asymmetry of the finger ridges was as important as whole brain and left hippocampal volumes in differentiating twins with a high susceptibility to schizophrenia from those with a low susceptibility...
  19. ncbi request reprint Quantitative genetic modeling of variation in human brain morphology
    W F Baaré
    Department of Psychiatry, University Medical Center Utrecht, The Netherlands
    Cereb Cortex 11:816-24. 2001
    ..The high heritability estimates that were found indicate that brain volumes may be useful as intermediate phenotypes in behavioral genetic research...
  20. doi request reprint The course of brain abnormalities in schizophrenia: can we slow the progression?
    N E van Haren
    Rudolf Magnus Institute of Neuroscience, Department of Psychiatry, University Medical Centre Utrecht, Utrecht, The Netherlands
    J Psychopharmacol 26:8-14. 2012
    ..Before being able to intervene with therapies and prevent the brain from shrinking, one has to understand the underlying mechanism of the progressive changes in the brains of schizophrenia patients...
  21. ncbi request reprint Brain volume changes in the first year of illness and 5-year outcome of schizophrenia
    W Cahn
    Department of Psychiatry, University Medical Center Utrecht, Heidelberglaan 100, 3584 GX Utrecht, The Netherlands
    Br J Psychiatry 189:381-2. 2006
    ..These findings suggest that early dynamic brain volume changes are related to the disease process and predict the longer-term outcome of schizophrenia...
  22. ncbi request reprint Brain morphology in antipsychotic-naïve schizophrenia: a study of multiple brain structures
    W Cahn
    Department of Psychiatry, University Medical Centre Utrecht, Heidelberglaan 100, 3584 CX Utrecht, The Netherlands
    Br J Psychiatry Suppl 43:s66-72. 2002
    ..Although brain volume changes are found in schizophrenia, only a limited number of structural magnetic resonance imaging studies have exclusively examined antipsychotic-naïve patients...
  23. ncbi request reprint Prenatal exposure to famine and brain morphology in schizophrenia
    H E Hulshoff Pol
    Department of Psychiatry, University Medical Center Utrecht, The Netherlands
    Am J Psychiatry 157:1170-2. 2000
    ..The authors assessed the effects of nutritional deficiency during the first trimester of pregnancy on brain morphology in patients with schizophrenia...
  24. ncbi request reprint Differential effects of DRD4 and DAT1 genotype on fronto-striatal gray matter volumes in a sample of subjects with attention deficit hyperactivity disorder, their unaffected siblings, and controls
    S Durston
    Department of Child and Adolescent Psychiatry, Rudolf Magnus Institute for Neuroscience, University Medical Center Utrecht, Utrecht, The Netherlands
    Mol Psychiatry 10:678-85. 2005
    ....
  25. pmc White matter development in early puberty: a longitudinal volumetric and diffusion tensor imaging twin study
    Rachel M Brouwer
    Department of Psychiatry, Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, Utrecht, The Netherlands
    PLoS ONE 7:e32316. 2012
    ..In children who showed the most pronounced white matter growth, fractional anisotropy increased the least and vice-versa. Thus, white matter development in childhood may reflect a process of both expansion and fiber optimization...
  26. ncbi request reprint Anatomical MRI of the developing human brain: what have we learned?
    S Durston
    Department of Child and Adolescent Psychiatry, University Medical Center Utrecht, The Netherlands
    J Am Acad Child Adolesc Psychiatry 40:1012-20. 2001
    ..To critically review and integrate the existing literature on magnetic resonance imaging (MRI) studies of the normally developing brain in childhood and adolescence and discuss the implications for clinical MRI studies...
  27. ncbi request reprint Effect of clozapine on caudate nucleus volume in relation to symptoms of schizophrenia
    F E Scheepers
    University Medical Center, Department of Psychiatry A00 241, P O Box 85500, 3508 GA Utrecht, Netherlands
    Am J Psychiatry 158:644-6. 2001
    ..In the current study the authors examined whether this volume decrease was related to clinical improvement...
  28. doi request reprint A meta-analysis of the polyunsaturated fatty acid composition of erythrocyte membranes in schizophrenia
    W J M van der Kemp
    Image Sciences Institute, Department of Radiology, University Medical Center Utrecht, The Netherlands, P O Box 85500, 3508 GA Utrecht, The Netherlands
    Schizophr Res 141:153-61. 2012
    ..Therefore PUFA may be involved in the excessive brain tissue loss reported in schizophrenia...
  29. ncbi request reprint Twin-singleton differences in brain structure using structural equation modelling
    H E Hulshoff Pol
    Department of Psychiatry, University Medical Centre, Utrecht, The Netherlands
    Brain 125:384-90. 2002
    ..Since other brain volume measures were comparable between the groups, twin studies can provide reliable estimates of heritabilities in brain volume measures and these can be generalized to the singleton population...
  30. doi request reprint Small-world and scale-free organization of voxel-based resting-state functional connectivity in the human brain
    M P van den Heuvel
    Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, Department of Psychiatry, Utrecht, The Netherlands
    Neuroimage 43:528-39. 2008
    ....