Danielle Horst

Summary

Affiliation: University Medical Center Utrecht
Country: The Netherlands

Publications

  1. pmc Hiding lipid presentation: viral interference with CD1d-restricted invariant natural killer T (iNKT) cell activation
    Danielle Horst
    Department of Medical Microbiology, University Medical Center Utrecht, 3584 CX Utrecht, The Netherlands
    Viruses 4:2379-99. 2012
  2. pmc The "Bridge" in the Epstein-Barr virus alkaline exonuclease protein BGLF5 contributes to shutoff activity during productive infection
    Danielle Horst
    Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands
    J Virol 86:9175-87. 2012
  3. doi Evaluation of viral interference with MHC class I-restricted antigen processing and presentation using a flow cytometry-based approach
    Danielle Horst
    Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, The Netherlands
    Methods Mol Biol 960:127-36. 2013
  4. doi EBV protein BNLF2a exploits host tail-anchored protein integration machinery to inhibit TAP
    Danielle Horst
    Department of Medical Microbiology, University Medical Center Utrecht, 3584 CX Utrecht, The Netherlands
    J Immunol 186:3594-605. 2011
  5. doi Exploiting human herpesvirus immune evasion for therapeutic gain: potential and pitfalls
    Danielle Horst
    Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, The Netherlands
    Immunol Cell Biol 89:359-66. 2011
  6. pmc Epstein-Barr virus isolates retain their capacity to evade T cell immunity through BNLF2a despite extensive sequence variation
    Danielle Horst
    Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, The Netherlands
    J Virol 86:572-7. 2012
  7. doi Viral interference with antigen presentation: trapping TAP
    Maaike E Ressing
    Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, The Netherlands
    Mol Immunol 55:139-42. 2013
  8. doi Viral evasion of T cell immunity: ancient mechanisms offering new applications
    Danielle Horst
    Department of Medical Microbiology, Center of Infectious Diseases, Leiden University Medical Center, Leiden, The Netherlands
    Curr Opin Immunol 23:96-103. 2011
  9. doi Specific targeting of the EBV lytic phase protein BNLF2a to the transporter associated with antigen processing results in impairment of HLA class I-restricted antigen presentation
    Danielle Horst
    Department of Medical Microbiology, Center of Infectious Diseases, Leiden University Medical Center, Leiden, The Netherlands
    J Immunol 182:2313-24. 2009

Detail Information

Publications9

  1. pmc Hiding lipid presentation: viral interference with CD1d-restricted invariant natural killer T (iNKT) cell activation
    Danielle Horst
    Department of Medical Microbiology, University Medical Center Utrecht, 3584 CX Utrecht, The Netherlands
    Viruses 4:2379-99. 2012
    ..Moreover, viruses have recently been found to use sophisticated strategies to withstand iNKT cell-mediated elimination. This review focuses on CD1d-restricted lipid presentation and the strategies viruses deploy to subvert this pathway...
  2. pmc The "Bridge" in the Epstein-Barr virus alkaline exonuclease protein BGLF5 contributes to shutoff activity during productive infection
    Danielle Horst
    Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands
    J Virol 86:9175-87. 2012
    ..These findings extend our understanding of the molecular basis for the shutoff function of BGLF5 that is conserved in gammaherpesviruses but not in alpha- and betaherpesviruses...
  3. doi Evaluation of viral interference with MHC class I-restricted antigen processing and presentation using a flow cytometry-based approach
    Danielle Horst
    Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, The Netherlands
    Methods Mol Biol 960:127-36. 2013
    ....
  4. doi EBV protein BNLF2a exploits host tail-anchored protein integration machinery to inhibit TAP
    Danielle Horst
    Department of Medical Microbiology, University Medical Center Utrecht, 3584 CX Utrecht, The Netherlands
    J Immunol 186:3594-605. 2011
    ..These results illustrate how EBV exploits a cellular pathway for TA protein biogenesis to achieve immune evasion, and they highlight the exquisite adaptation of this virus to its host...
  5. doi Exploiting human herpesvirus immune evasion for therapeutic gain: potential and pitfalls
    Danielle Horst
    Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, The Netherlands
    Immunol Cell Biol 89:359-66. 2011
    ..Here, we review and discuss recent efforts to exploit human herpesvirus MHC class I evasion strategies for the rational design of novel strategies for vaccine development, cancer treatment, transplant protection and gene therapy...
  6. pmc Epstein-Barr virus isolates retain their capacity to evade T cell immunity through BNLF2a despite extensive sequence variation
    Danielle Horst
    Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, The Netherlands
    J Virol 86:572-7. 2012
    ..This conservation of BNLF2a function during evolution of EBV implies an important role for the viral TAP inhibitor in preventing T cell recognition during viral infection...
  7. doi Viral interference with antigen presentation: trapping TAP
    Maaike E Ressing
    Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, The Netherlands
    Mol Immunol 55:139-42. 2013
    ....
  8. doi Viral evasion of T cell immunity: ancient mechanisms offering new applications
    Danielle Horst
    Department of Medical Microbiology, Center of Infectious Diseases, Leiden University Medical Center, Leiden, The Netherlands
    Curr Opin Immunol 23:96-103. 2011
    ..Moreover, viral immune evasion proteins constitute extremely useful tools to block defined stages of the MHC class I presentation pathway, not only for research purposes, but also for clinical applications...
  9. doi Specific targeting of the EBV lytic phase protein BNLF2a to the transporter associated with antigen processing results in impairment of HLA class I-restricted antigen presentation
    Danielle Horst
    Department of Medical Microbiology, Center of Infectious Diseases, Leiden University Medical Center, Leiden, The Netherlands
    J Immunol 182:2313-24. 2009
    ..In this way, EBV BNLF2a-mediated evasion from HLA class I-restricted T cell immunity contributes to creating a window for undetected virus production...