Gert Holstege

Summary

Affiliation: University of Groningen
Country: The Netherlands

Publications

  1. ncbi Location of bladder and urethral sphincter motoneurons in the male guinea pig (Cavia porcellus)
    Rutger Kuipers
    Department of Anatomy and Embryology, Faculty of Medical Sciences, University of Groningen, Antonius Deusinglaan 1, 9713 AV Groningen, The Netherlands
    Neurosci Lett 362:57-60. 2004
  2. ncbi Central nervous system control of ejaculation
    Gert Holstege
    Department of Anatomy and Embryology, Faculty of Medical Sciences, University of Groningen, A Deusinglaan 1, 9713 AV Groningen, The Netherlands
    World J Urol 23:109-14. 2005
  3. ncbi Regional cerebral blood flow changes associated with clitorally induced orgasm in healthy women
    Janniko R Georgiadis
    Department of Anatomy and Embryology, University Medical Center Groningen, University of Groningen, Antonius Deusinglaan 1, bldg 3215 room 729, 9713 AV Groningen, The Netherlands
    Eur J Neurosci 24:3305-16. 2006
  4. ncbi Brain activation during human male ejaculation
    Gert Holstege
    Department of Anatomy and Embryology, University of Groningen, 9713 AV Groningen, The Netherlands
    J Neurosci 23:9185-93. 2003
  5. ncbi The emotional brain: neural correlates of cat sexual behavior and human male ejaculation
    Gert Holstege
    Department of Anatomy and Embryology, University of Groningen, Groningen 9713 AV, The Netherlands
    Prog Brain Res 143:39-45. 2004
  6. ncbi Neurons in the lateral sacral cord of the cat project to periaqueductal grey, but not to thalamus
    Esther Marije Klop
    Department of Anatomy and Embryology, University of Groningen Medical Center, Antonius Deusinglaan 1, bldg 3215, PO Box 196, 9700 AD Groningen, The Netherlands
    Eur J Neurosci 21:2159-66. 2005
  7. ncbi Periparabigeminal and adjoining mesencephalic tegmental field projections to the dorsolateral periaqueductal grey in cat - a possible role for oculomotor input in the defensive system
    Esther Marije Klop
    Department of Anatomy and Embryology, University Medical Center Groningen, University of Groningen, Antonius Deusinglaan 1, bldg 3215, PO Box 196, 9700 AD Groningen, The Netherlands
    Eur J Neurosci 23:2145-57. 2006
  8. ncbi Infralimbic cortex projects to all parts of the pontine and medullary lateral tegmental field in cat
    Rutger Kuipers
    Department of Anatomy and Embryology, University Medical Center Groningen, University of Groningen, Antonius Deusinglaan 1, bldg 3215, PO Box 196, 9713 AV Groningen, The Netherlands
    Eur J Neurosci 23:3014-24. 2006
  9. ncbi Segmental and laminar organization of the spinothalamic neurons in cat: evidence for at least five separate clusters
    Esther Marije Klop
    Department of Anatomy and Embryology, University Medical Center Groningen, University of Groningen, 9700 AD Groningen, The Netherlands
    J Comp Neurol 493:580-95. 2005
  10. doi The nucleus retroambiguus control of respiration
    Hari H Subramanian
    Center for Uroneurology, University of Groningen, University Medical Center Groningen, 9700 RB Groningen, The Netherlands
    J Neurosci 29:3824-32. 2009

Collaborators

Detail Information

Publications26

  1. ncbi Location of bladder and urethral sphincter motoneurons in the male guinea pig (Cavia porcellus)
    Rutger Kuipers
    Department of Anatomy and Embryology, Faculty of Medical Sciences, University of Groningen, Antonius Deusinglaan 1, 9713 AV Groningen, The Netherlands
    Neurosci Lett 362:57-60. 2004
    ..The external urethral sphincter motoneurons were found to be located in the ventral horn of the first sacral segment, in a cell group corresponding with the nucleus of Onuf in cat and human...
  2. ncbi Central nervous system control of ejaculation
    Gert Holstege
    Department of Anatomy and Embryology, Faculty of Medical Sciences, University of Groningen, A Deusinglaan 1, 9713 AV Groningen, The Netherlands
    World J Urol 23:109-14. 2005
    ..Especially the ventral tegmental area and the cerebellum seem to be activated during ejaculation, while the amygdala region is deactivated. Apparently, a general lack of fear is necessary for ejaculation to occur...
  3. ncbi Regional cerebral blood flow changes associated with clitorally induced orgasm in healthy women
    Janniko R Georgiadis
    Department of Anatomy and Embryology, University Medical Center Groningen, University of Groningen, Antonius Deusinglaan 1, bldg 3215 room 729, 9713 AV Groningen, The Netherlands
    Eur J Neurosci 24:3305-16. 2006
    ..In addition, the deep cerebellar nuclei may be involved in orgasm-specific muscle contractions while the involvement of the ventral midbrain and right caudate nucleus suggests a role for dopamine in female sexual arousal and orgasm...
  4. ncbi Brain activation during human male ejaculation
    Gert Holstege
    Department of Anatomy and Embryology, University of Groningen, 9713 AV Groningen, The Netherlands
    J Neurosci 23:9185-93. 2003
    ....
  5. ncbi The emotional brain: neural correlates of cat sexual behavior and human male ejaculation
    Gert Holstege
    Department of Anatomy and Embryology, University of Groningen, Groningen 9713 AV, The Netherlands
    Prog Brain Res 143:39-45. 2004
    ..Further study of these structures should certainly lead to better insight into human sexual behavior and provide the possibility to improve sexual activity in those who suffer from problems in this area...
  6. ncbi Neurons in the lateral sacral cord of the cat project to periaqueductal grey, but not to thalamus
    Esther Marije Klop
    Department of Anatomy and Embryology, University of Groningen Medical Center, Antonius Deusinglaan 1, bldg 3215, PO Box 196, 9700 AD Groningen, The Netherlands
    Eur J Neurosci 21:2159-66. 2005
    ..These results suggest that afferent information regarding micturition and sexual behaviour is relayed to the PAG, rather than to the thalamus...
  7. ncbi Periparabigeminal and adjoining mesencephalic tegmental field projections to the dorsolateral periaqueductal grey in cat - a possible role for oculomotor input in the defensive system
    Esther Marije Klop
    Department of Anatomy and Embryology, University Medical Center Groningen, University of Groningen, Antonius Deusinglaan 1, bldg 3215, PO Box 196, 9700 AD Groningen, The Netherlands
    Eur J Neurosci 23:2145-57. 2006
    ..We hypothesize that PAGdl is alerted by sudden changes in the visual field, and that the PAGdl defensive system is inhibited when these changes are caused by eye movements...
  8. ncbi Infralimbic cortex projects to all parts of the pontine and medullary lateral tegmental field in cat
    Rutger Kuipers
    Department of Anatomy and Embryology, University Medical Center Groningen, University of Groningen, Antonius Deusinglaan 1, bldg 3215, PO Box 196, 9713 AV Groningen, The Netherlands
    Eur J Neurosci 23:3014-24. 2006
    ..These results show that the ILc projects to the LTF in cat and can possibly modulate the fear response not only via indirect but also via direct routes to the premotor interneurons in the brainstem...
  9. ncbi Segmental and laminar organization of the spinothalamic neurons in cat: evidence for at least five separate clusters
    Esther Marije Klop
    Department of Anatomy and Embryology, University Medical Center Groningen, University of Groningen, 9700 AD Groningen, The Netherlands
    J Comp Neurol 493:580-95. 2005
    ..The location of the spinothalamic neurons shows remarkable similarities, but also differences, with the location of spino-periaqueductal gray neurons...
  10. doi The nucleus retroambiguus control of respiration
    Hari H Subramanian
    Center for Uroneurology, University of Groningen, University Medical Center Groningen, 9700 RB Groningen, The Netherlands
    J Neurosci 29:3824-32. 2009
    ..Higher brainstem regions such as the midbrain periaqueductal gray (PAG) decides which combination of NRA neurons are excited. In simple terms, the NRA is the piano, the PAG one of the piano players...
  11. ncbi Two parts of the nucleus prepositus hypoglossi project to two different subdivisions of the dorsolateral periaqueductal gray in cat
    Esther Marije Klop
    Department of Anatomy and Embryology, University Medical Center Groningen, University of Groningen, 9700 AD Groningen, The Netherlands
    J Comp Neurol 492:303-22. 2005
    ..These separate PPH projections suggest that two subdivisions exist within the dorsolateral PAG. The present findings suggest a role for the dorsolateral PAG in the oculomotor system...
  12. ncbi Afferent projections to the pontine micturition center in the cat
    Rutger Kuipers
    Department of Anatomy and Embryology, University Medical Center Groningen, The Netherlands
    J Comp Neurol 494:36-53. 2006
    ..The possible functions of these projections are discussed. These results indicate that all other parts of the brain that influence micturition have no direct connection with the PMC...
  13. ncbi Human brain activation during sexual stimulation of the penis
    Janniko R Georgiadis
    Department of Anatomy and Embryology, University Medical Center Groningen, 9713 AV Groningen, The Netherlands
    J Comp Neurol 493:33-8. 2005
    ..Deactivation of the amygdala during sexual stimulation of the penis corresponds with a decrease of vigilance during sexual performance...
  14. doi Brain circuits for mating behavior in cats and brain activations and de-activations during sexual stimulation and ejaculation and orgasm in humans
    Gert Holstege
    University of Groningen, UMCG, Center for Uroneurology, Postbus 196, 9700 AD Groningen, The Netherlands
    Horm Behav 59:702-7. 2011
    ..These neuroimaging results show the importance of lowering the level of alertness regarding your immediate environment (left hemisphere) to have proper sexual behavior...
  15. ncbi C1-C3 spinal cord projections to periaqueductal gray and thalamus: a quantitative retrograde tracing study in cat
    Leonora J Mouton
    Department of Anatomy and Embryology, University of Groningen Medical Centre, A Deusinglaan 1, 9713 AV Groningen, The Netherlands
    Brain Res 1043:87-94. 2005
    ....
  16. ncbi Afferent projections to pharynx and soft palate motoneurons: a light and electron microscopical tracing study in the cat
    Jose Boers
    Department of Anatomy and Embryology, Faculty of Medicine, University of Groningen, 9700 AD Groningen, The Netherlands
    J Comp Neurol 486:18-38. 2005
    ..In conclusion, pharyngeal and soft palate motoneurons receive their afferents almost exclusively from the pontine and medullary tegmentum and first cervical spinal segment...
  17. ncbi Ultrastructural evidence for a direct excitatory pathway from the nucleus retroambiguus to lateral longissimus and quadratus lumborum motoneurons in the female golden hamster
    Peter O Gerrits
    Department of Anatomy and Embryology, Faculty of Medical Sciences, University of Groningen, Ant Deusinglaan 1, 9700 AD Groningen, The Netherlands
    J Comp Neurol 480:352-63. 2004
    ..These results correspond with the hypothesis that in hamster the PAG-NRA-motoneuronal projection not only involves motoneurons of iliopsoas and cutaneus trunci but also of LL and QL...
  18. ncbi Micturition and the soul
    Gert Holstege
    Department of Anatomy and Embryology, University Medical Center Groningen, University of Groningen, 9713 AV Groningen, The Netherlands
    J Comp Neurol 493:15-20. 2005
    ..It seems that the many structures in the brain that are known to influence micturition use the PAG as relay to the PMC. This basic organization has to be kept in mind in the fight against overactive bladder (OAB) and urge-incontinence...
  19. ncbi Lateral cervical nucleus projections to periaqueductal gray matter in cat
    Leonora J Mouton
    Department of Anatomy and Embryology, Faculty of Medical Sciences, Rijksuniversiteit Groningen, 9713 AV Groningen, The Netherlands
    J Comp Neurol 471:434-45. 2004
    ..A concept is put forward according to which the LCN-PAG pathway alerts the animal about the presence of cutaneous stimuli that might represent danger, necessitating flight. J. Comp. Neurol. 471:434-445, 2004...
  20. doi Periaqueductal gray control of breathing
    Hari H Subramanian
    University of Groningen, UMCG, Center for Uroneurology, 9700RB Groningen, The Netherlands
    Adv Exp Med Biol 669:353-8. 2010
    ..Through these pathways the PAG can change eupneic respiratory rhythm into the behavior necessary for that specific situation. We present data obtained from the cat and propose a functional framework for the breathing control pathways...
  21. doi The midbrain periaqueductal gray control of respiration
    Hari H Subramanian
    Center for Uroneurology, University Medical Center Groningen, University of Groningen, 9700 RB Groningen, The Netherlands
    J Neurosci 28:12274-83. 2008
    ..These results demonstrate that the PAG exerts a strong influence on respiration, suggesting that it serves as the behavioral modulator of breathing...
  22. ncbi Central nervous system control of micturition
    Gert Holstege
    Department of Anatomy and Embryology, Faculty of Medical Sciences, University of Groningen, A Deusinglaan 1, 9713 AV Groningen, The Netherlands
    Int Rev Neurobiol 56:123-45. 2003
  23. ncbi Nucleus retroambiguus projections to the periaqueductal gray in the cat
    Esther Marije Klop
    Department of Anatomy and Embryology, Faculty of Medical Sciences, Rijksuniversiteit Groningen, Antonius Deusinglaan 1, bldg 3215, 9700 AD Groningen, The Netherlands
    J Comp Neurol 445:47-58. 2002
    ....
  24. ncbi Emotional innervation of facial musculature
    Gert Holstege
    Department of Anatomy and Embryology, Groningen Medical School, University of Groningen, Groningen, The Netherlands
    Mov Disord 17:S12-6. 2002
  25. ncbi Spatiotemporal activation of lumbosacral motoneurons in the locomotor step cycle
    Sergiy Yakovenko
    Center for Neuroscience, University of Alberta, Edmonton, Alberta T6G 2S2, Canada
    J Neurophysiol 87:1542-53. 2002
    ..The model can be used in the future to characterize spatiotemporal activity of spinal MNs in the absence of descending and sensory inputs and to compare these to spatiotemporal patterns in spinal MNs in normal locomotion...
  26. pmc Functional sex differences in human primary auditory cortex
    Liesbet Ruytjens
    Department of Otorhinolaryngology, University Medical Center Groningen, Groningen, The Netherlands
    Eur J Nucl Med Mol Imaging 34:2073-81. 2007
    ..Regional cerebral blood flow (rCBF) was measured in 10 male and 10 female volunteers while listening to sounds (music or white noise) and during a baseline (no auditory stimulation)...