D Hoekstra

Summary

Affiliation: University Medical Center Groningen
Country: The Netherlands

Publications

  1. ncbi request reprint Gene delivery by cationic lipids: in and out of an endosome
    D Hoekstra
    Department of Cell Biology, Section Membrane Cell Biology, University Medical Center Groningen, University of Groningen, Antonius Deusinglaan 1, 9713 AV Groningen, The Netherlands
    Biochem Soc Trans 35:68-71. 2007
  2. pmc PDMP blocks brefeldin A-induced retrograde membrane transport from golgi to ER: evidence for involvement of calcium homeostasis and dissociation from sphingolipid metabolism
    J W Kok
    Department of Physiological Chemistry, University of Groningen, Groningen Institute for Drug Studies GIDS, 9713 AV Groningen, The Netherlands
    J Cell Biol 142:25-38. 1998
  3. pmc Efficient cationic lipid-mediated delivery of antisense oligonucleotides into eukaryotic cells: down-regulation of the corticotropin-releasing factor receptor
    F Shi
    Department of Membrane Cell Biology, University of Groningen, Faculty of Medical Sciences, Antonius Deusinglaan 1, 9713 AV Groningen, The Netherlands
    Nucleic Acids Res 29:2079-87. 2001
  4. pmc An apical-type trafficking pathway is present in cultured oligodendrocytes but the sphingolipid-enriched myelin membrane is the target of a basolateral-type pathway
    H de Vries
    Department of Physiological Chemistry, Faculty of Medical Sciences, University of Groningen, The Netherlands
    Mol Biol Cell 9:599-609. 1998
  5. ncbi request reprint Molecular shape of the cationic lipid controls the structure of cationic lipid/dioleylphosphatidylethanolamine-DNA complexes and the efficiency of gene delivery
    J Smisterov√°
    Department of Membrane Cell Biology, University of Groningen, Faculty of Medical Sciences, A Deusinglaan 1, 9713 AV Groningen, The Netherlands
    J Biol Chem 276:47615-22. 2001
  6. ncbi request reprint Membrane fusion induced by 11-mer anionic and cationic peptides: a structure-function study
    E I Pecheur
    Department of Physiological Chemistry, University of Groningen, Antonius Deusinglaan 1, 9713 AV Groningen, The Netherlands
    Biochemistry 37:2361-71. 1998
  7. ncbi request reprint On the mechanism of cationic amphiphile-mediated transfection. To fuse or not to fuse: is that the question?
    I S Zuhorn
    Department of Membrane Cell Biology, Faculty of Medical Sciences, University of Groningen, A Deusinglaan 1, 9713 AV, Groningen, The Netherlands
    J Membr Biol 189:167-79. 2002
  8. ncbi request reprint Cationic lipid-mediated transfection in vitro and in vivo (review)
    S Audouy
    Department of Membrane Cell Biology, Faculty of Medical Sciences, University of Groningen, The Netherlands
    Mol Membr Biol 18:129-43. 2001
  9. pmc Ceramide transport from endoplasmic reticulum to Golgi apparatus is not vesicle-mediated
    J W Kok
    University of Groningen, Department of Physiological Chemistry, A Deusinglaan 1, 9713 AV Groningen, The Netherlands
    Biochem J 333:779-86. 1998
  10. pmc Reconstitution of membrane proteins into giant unilamellar vesicles via peptide-induced fusion
    N Kahya
    Ultrafast Laser and Spectroscopy Laboratory, Optical Sciences, Materials Science Centre, University of Groningen, Nijenborgh 4, 9747 AG Groningen, The Netherlands
    Biophys J 81:1464-74. 2001

Collaborators

Detail Information

Publications13

  1. ncbi request reprint Gene delivery by cationic lipids: in and out of an endosome
    D Hoekstra
    Department of Cell Biology, Section Membrane Cell Biology, University Medical Center Groningen, University of Groningen, Antonius Deusinglaan 1, 9713 AV Groningen, The Netherlands
    Biochem Soc Trans 35:68-71. 2007
    ..To further clarify molecular mechanisms and to appreciate and overcome intracellular hurdles in lipoplex-mediated gene delivery, quantification of distinct steps in overall transfection and proper model systems are required...
  2. pmc PDMP blocks brefeldin A-induced retrograde membrane transport from golgi to ER: evidence for involvement of calcium homeostasis and dissociation from sphingolipid metabolism
    J W Kok
    Department of Physiological Chemistry, University of Groningen, Groningen Institute for Drug Studies GIDS, 9713 AV Groningen, The Netherlands
    J Cell Biol 142:25-38. 1998
    ..Thus, the biological effects of PDMP revealed a relation between three important physiological processes of multidrug resistance, calcium homeostasis, and membrane flow in the ER/ Golgi system...
  3. pmc Efficient cationic lipid-mediated delivery of antisense oligonucleotides into eukaryotic cells: down-regulation of the corticotropin-releasing factor receptor
    F Shi
    Department of Membrane Cell Biology, University of Groningen, Faculty of Medical Sciences, Antonius Deusinglaan 1, 9713 AV Groningen, The Netherlands
    Nucleic Acids Res 29:2079-87. 2001
    ....
  4. pmc An apical-type trafficking pathway is present in cultured oligodendrocytes but the sphingolipid-enriched myelin membrane is the target of a basolateral-type pathway
    H de Vries
    Department of Physiological Chemistry, Faculty of Medical Sciences, University of Groningen, The Netherlands
    Mol Biol Cell 9:599-609. 1998
    ..These remarkable results emphasize that polarity and regulation of membrane transport in cultured OLG display features that are quite different from those in polarized cells...
  5. ncbi request reprint Molecular shape of the cationic lipid controls the structure of cationic lipid/dioleylphosphatidylethanolamine-DNA complexes and the efficiency of gene delivery
    J Smisterov√°
    Department of Membrane Cell Biology, University of Groningen, Faculty of Medical Sciences, A Deusinglaan 1, 9713 AV Groningen, The Netherlands
    J Biol Chem 276:47615-22. 2001
    ..We conclude that in the DOPE-containing complexes the molecular shape and the nonbilayer preferences of the cationic lipid control the topology of the lipoplex and thereby the transfection efficiency...
  6. ncbi request reprint Membrane fusion induced by 11-mer anionic and cationic peptides: a structure-function study
    E I Pecheur
    Department of Physiological Chemistry, University of Groningen, Antonius Deusinglaan 1, 9713 AV Groningen, The Netherlands
    Biochemistry 37:2361-71. 1998
    ..The data also reveal a certain degree of sequence specificity in WAE-induced fusion...
  7. ncbi request reprint On the mechanism of cationic amphiphile-mediated transfection. To fuse or not to fuse: is that the question?
    I S Zuhorn
    Department of Membrane Cell Biology, Faculty of Medical Sciences, University of Groningen, A Deusinglaan 1, 9713 AV, Groningen, The Netherlands
    J Membr Biol 189:167-79. 2002
    ..Ultimately, cationic lipids may be used in gene therapeutic protocols...
  8. ncbi request reprint Cationic lipid-mediated transfection in vitro and in vivo (review)
    S Audouy
    Department of Membrane Cell Biology, Faculty of Medical Sciences, University of Groningen, The Netherlands
    Mol Membr Biol 18:129-43. 2001
    ..Here, most recent advances in cationic lipid-mediated gene delivery are discussed from such a perspective...
  9. pmc Ceramide transport from endoplasmic reticulum to Golgi apparatus is not vesicle-mediated
    J W Kok
    University of Groningen, Department of Physiological Chemistry, A Deusinglaan 1, 9713 AV Groningen, The Netherlands
    Biochem J 333:779-86. 1998
    ..These results indicate that [14C]Cer is transferred from ER to Golgi by a non-vesicular mechanism...
  10. pmc Reconstitution of membrane proteins into giant unilamellar vesicles via peptide-induced fusion
    N Kahya
    Ultrafast Laser and Spectroscopy Laboratory, Optical Sciences, Materials Science Centre, University of Groningen, Nijenborgh 4, 9747 AG Groningen, The Netherlands
    Biophys J 81:1464-74. 2001
    ..2 microm(2)/s. The current procedure offers new opportunities to address issues related to membrane-protein structure and dynamics in a close-to-native state...
  11. ncbi request reprint Lipid trafficking and sorting: how cholesterol is filling gaps
    D Hoekstra
    Department of Physiological Chemistry, University of Groningen, Groningen, 9713 AV, The Netherlands
    Curr Opin Cell Biol 12:496-502. 2000
    ..Recently, several proteins have been identified that play a role in the flow and sorting of all major lipid classes...
  12. ncbi request reprint In-vivo delivery of DNA and protein using conceptually new cationic, sunfish', amphiphiles
    M Haas
    BioMaDe, Nijenborgh 4, 9747 AG Groningen, The Netherlands
    J Control Release 101:401. 2005
  13. ncbi request reprint Functional mapping of the cytoplasmic region of intercellular adhesion molecule-3 reveals important roles for serine residues
    J S Hayflick
    ICOS Corporation, Bothell, Washington 98021, USA
    J Biol Chem 272:22207-14. 1997
    ..This study delineates separable regions and amino acid residues within the cytoplasmic portion of ICAM-3 that are important for T cell function...