Imo E Hoefer

Summary

Affiliation: University Medical Center Utrecht
Country: The Netherlands

Publications

  1. pmc Toll-Like Receptor induced CD11b and L-selectin response in patients with coronary artery disease
    Ellen H A M Elsenberg
    Laboratory of Experimental Cardiology, University Medical Centre Utrecht, Utrecht, The Netherlands
    PLoS ONE 8:e60467. 2013
  2. doi request reprint Circulating cells as predictors of secondary manifestations of cardiovascular disease: design of the CIRCULATING CELLS study
    Imo E Hoefer
    Laboratory of Experimental Cardiology, UMC Utrecht, Room G02 523, Heidelberglaan 100, 3584, Utrecht, CX, The Netherlands
    Clin Res Cardiol 102:847-56. 2013
  3. ncbi request reprint Admittance-based pressure-volume loop measurements in a porcine model of chronic myocardial infarction
    G P J van Hout
    I E Hoefer Laboratory of Experimental Cardiology room G02 523, University Medical Centre Utrecht, Heidelberglaan 100, PO Box 85500, 3508 GA, Utrecht, The Netherlands
    Exp Physiol 98:1565-75. 2013
  4. doi request reprint Biomechanical factors as triggers of vascular growth
    Imo E Hoefer
    Laboratory of Experimental Cardiology, University Medical Center, G02 523, Heidelberglaan 100, Utrecht 3584 CX, The Netherlands
    Cardiovasc Res 99:276-83. 2013
  5. ncbi request reprint Targeting adhesion molecules in cardiovascular disorders
    René Haverslag
    Experimental Cardiology, UMC Utrecht, G02 523, Heidelberglaan 100, 3584 CX Utrecht, The Netherlands
    Cardiovasc Hematol Disord Drug Targets 8:252-60. 2008
  6. doi request reprint Locally applied recombinant plasmin results in effective thrombolysis in a porcine model of arteriovenous graft thrombosis
    Imo E Hoefer
    Laboratory of Experimental Cardiology, University Medical Center Utrecht, Utrecht, The Netherlands
    J Vasc Interv Radiol 20:951-8. 2009
  7. ncbi request reprint Growth factor therapy in atherosclerotic disease-friend or foe
    Imo E Hoefer
    Dept of Experimental Cardiology, UMC Utrecht, Utrecht, Netherlands
    Curr Pharm Des 13:1803-10. 2007
  8. ncbi request reprint Pharmaceutical interventions to influence arteriogenesis: new concepts to treat ischemic heart disease
    Imo E Hoefer
    Dept of Experimental Cardiology, UMC Utrecht, Netherlands
    Curr Med Chem 13:979-87. 2006
  9. ncbi request reprint CD26 inhibition enhances perfusion recovery in ApoE-/-mice
    René T Haverslag
    Laboratory of Experimental Cardiology, University Medical Center Utrecht, G02 523, Heidelberglaan 100, 3584 CX Utrecht, The Netherlands
    Curr Vasc Pharmacol 11:21-8. 2013
  10. doi request reprint Absence of chemokine (C-x-C motif) ligand 10 diminishes perfusion recovery after local arterial occlusion in mice
    Pleunie van den Borne
    From the Laboratory of Experimental Cardiology P v d B, R T H, I E H, G P, D P V d K, Department of Nephrology and Hypertension C C, and Department of Cardiology H J D, University Medical Center Utrecht, Utrecht, The Netherlands Molecular Cardiology Laboratory, Experimental Cardiology, Erasmus Medical Center, Rotterdam, The Netherlands M M B, C C Department of Surgery P H A Q and Einthoven Laboratory of Experimental Vascular Medicine P H A Q, Leiden University Medical Center, Leiden, The Netherlands Interuniversity Cardiology Institute of the Netherlands, Utrecht, The Netherlands I E H, G P, D P V d K and Cardiovascular Research Institute and Surgery, National University Hospital, Singapore, Singapore D P V d K
    Arterioscler Thromb Vasc Biol 34:594-602. 2014

Collaborators

Detail Information

Publications57

  1. pmc Toll-Like Receptor induced CD11b and L-selectin response in patients with coronary artery disease
    Ellen H A M Elsenberg
    Laboratory of Experimental Cardiology, University Medical Centre Utrecht, Utrecht, The Netherlands
    PLoS ONE 8:e60467. 2013
    ..However, both single dose stimulation and dose-response curves of LPS-induced L-selectin expression can discriminate between controls and CAD patients...
  2. doi request reprint Circulating cells as predictors of secondary manifestations of cardiovascular disease: design of the CIRCULATING CELLS study
    Imo E Hoefer
    Laboratory of Experimental Cardiology, UMC Utrecht, Room G02 523, Heidelberglaan 100, 3584, Utrecht, CX, The Netherlands
    Clin Res Cardiol 102:847-56. 2013
    ..Overall, the CIRCULATING CELLS study grants the interesting possibility that it will both identify novel biomarkers and provide useful insights into the pathophysiology of CAD in patients...
  3. ncbi request reprint Admittance-based pressure-volume loop measurements in a porcine model of chronic myocardial infarction
    G P J van Hout
    I E Hoefer Laboratory of Experimental Cardiology room G02 523, University Medical Centre Utrecht, Heidelberglaan 100, PO Box 85500, 3508 GA, Utrecht, The Netherlands
    Exp Physiol 98:1565-75. 2013
    ....
  4. doi request reprint Biomechanical factors as triggers of vascular growth
    Imo E Hoefer
    Laboratory of Experimental Cardiology, University Medical Center, G02 523, Heidelberglaan 100, Utrecht 3584 CX, The Netherlands
    Cardiovasc Res 99:276-83. 2013
    ..Finally, current approaches to modify biomechanical forces to therapeutically modulate vascular growth in humans will be described. ..
  5. ncbi request reprint Targeting adhesion molecules in cardiovascular disorders
    René Haverslag
    Experimental Cardiology, UMC Utrecht, G02 523, Heidelberglaan 100, 3584 CX Utrecht, The Netherlands
    Cardiovasc Hematol Disord Drug Targets 8:252-60. 2008
    ..This review focuses on the role of cell adhesion molecules in cardiovascular disease and the use of targeting adhesion molecules for imaging purposes and local drug delivery in cardiovascular medicine...
  6. doi request reprint Locally applied recombinant plasmin results in effective thrombolysis in a porcine model of arteriovenous graft thrombosis
    Imo E Hoefer
    Laboratory of Experimental Cardiology, University Medical Center Utrecht, Utrecht, The Netherlands
    J Vasc Interv Radiol 20:951-8. 2009
    ..Locally delivered plasmin may have similar thrombolytic efficacy with a superior safety profile, so herein it was compared with TPA in a porcine model of AV graft thrombosis...
  7. ncbi request reprint Growth factor therapy in atherosclerotic disease-friend or foe
    Imo E Hoefer
    Dept of Experimental Cardiology, UMC Utrecht, Utrecht, Netherlands
    Curr Pharm Des 13:1803-10. 2007
    ..This review discusses the delicate balance between the benefits and the drawbacks of therapeutic strategies to influence angiogenesis and arteriogenesis...
  8. ncbi request reprint Pharmaceutical interventions to influence arteriogenesis: new concepts to treat ischemic heart disease
    Imo E Hoefer
    Dept of Experimental Cardiology, UMC Utrecht, Netherlands
    Curr Med Chem 13:979-87. 2006
    ..This review focuses on the basic mechanisms of arteriogenesis, the recent progresses in translating these insights into the clinical situation and the problems yet to be solved...
  9. ncbi request reprint CD26 inhibition enhances perfusion recovery in ApoE-/-mice
    René T Haverslag
    Laboratory of Experimental Cardiology, University Medical Center Utrecht, G02 523, Heidelberglaan 100, 3584 CX Utrecht, The Netherlands
    Curr Vasc Pharmacol 11:21-8. 2013
    ..We hypothesized that blocking SDF-1 alpha inactivation, using a commercially available CD26 inhibitor, accelerates perfusion recovery without detrimental side effects on plaque stability...
  10. doi request reprint Absence of chemokine (C-x-C motif) ligand 10 diminishes perfusion recovery after local arterial occlusion in mice
    Pleunie van den Borne
    From the Laboratory of Experimental Cardiology P v d B, R T H, I E H, G P, D P V d K, Department of Nephrology and Hypertension C C, and Department of Cardiology H J D, University Medical Center Utrecht, Utrecht, The Netherlands Molecular Cardiology Laboratory, Experimental Cardiology, Erasmus Medical Center, Rotterdam, The Netherlands M M B, C C Department of Surgery P H A Q and Einthoven Laboratory of Experimental Vascular Medicine P H A Q, Leiden University Medical Center, Leiden, The Netherlands Interuniversity Cardiology Institute of the Netherlands, Utrecht, The Netherlands I E H, G P, D P V d K and Cardiovascular Research Institute and Surgery, National University Hospital, Singapore, Singapore D P V d K
    Arterioscler Thromb Vasc Biol 34:594-602. 2014
    ..Toll-like receptors are involved in arteriogenesis; however, the role of CXCL10 is still unclear. In this study, we investigated the role for CXCL10 in a murine hindlimb ischemia model...
  11. doi request reprint Arteriogenesis requires toll-like receptor 2 and 4 expression in bone-marrow derived cells
    Daphne de Groot
    Laboratory of Experimental Cardiology, HLCU, UMC, University of Utrecht, The Netherlands
    J Mol Cell Cardiol 50:25-32. 2011
    ..This study illustrates the involvement of TLR 2 and TLR 4 in adaptive collateral artery growth and shows the importance of TLR 2 and 4 expression by bone-marrow derived cells for this process...
  12. doi request reprint Targeted deletion of nuclear factor kappaB p50 enhances cardiac remodeling and dysfunction following myocardial infarction
    Leo Timmers
    Department of Cardiology, University Medical Center Utrecht, Utrecht, The Netherlands
    Circ Res 104:699-706. 2009
    ..In conclusion, targeted deletion of NF-kappaB p50 results in enhanced cardiac remodeling and functional deterioration following myocardial infarction by increasing matrix remodeling and inflammation...
  13. doi request reprint Lack of fibronectin-EDA promotes survival and prevents adverse remodeling and heart function deterioration after myocardial infarction
    Fatih Arslan
    Laboratory of Experimental Cardiology, University Medical Center Utrecht, Heidelberglaan 100, 3584 CX Utrecht, The Netherlands
    Circ Res 108:582-92. 2011
    ..The extracellular matrix protein fibronectin-EDA (EIIIA; EDA) is upregulated after tissue injury and may act as a "danger signal" for leukocytes to cause adverse cardiac remodeling after infarction...
  14. doi request reprint Human mesenchymal stem cell-conditioned medium improves cardiac function following myocardial infarction
    Leo Timmers
    Department of Cardiology, University Medical Center Utrecht, Netherlands
    Stem Cell Res 6:206-14. 2011
    ..Intravenous MSC-CM treatment after myocardial infarction increases capillary density and preserves cardiac function, probably by increasing myocardial perfusion...
  15. ncbi request reprint Soluble ST2 levels are not associated with secondary cardiovascular events and vulnerable plaque phenotype in patients with carotid artery stenosis
    Sanne Willems
    Laboratory of Experimental Cardiology, University Medical Center Utrecht, Utrecht, The Netherlands Electronic address
    Atherosclerosis 231:48-53. 2013
    ..In addition, sST2 levels were associated to patient clinical data and atherosclerotic plaque characteristics...
  16. doi request reprint Temporal changes of soluble ST2 after cardiovascular interventions
    Sanne Willems
    Department of Experimental Cardiology, University Medical Centre Utrecht, 3584 CX, Utrecht, The Netherlands
    Eur J Clin Invest 43:113-20. 2013
    ..The influence of clinical characteristics on variability of sST2 levels is relatively unexplored. Here, we studied the effect of cardiovascular interventions and clinical characteristics on plasma sST2 expression levels...
  17. doi request reprint Targeted deletion of the inhibitory NF-kappaB p50 subunit in bone marrow-derived cells improves collateral growth after arterial occlusion
    Daphne de Groot
    Laboratory of Experimental Cardiology, UMC, Utrecht, The Netherlands
    Cardiovasc Res 88:179-85. 2010
    ..We hypothesized that NF-κB p50 is a regulator of the inflammatory response after arterial occlusion and subsequent collateral perfusion...
  18. doi request reprint Circumferential heterogeneity in the abdominal aortic aneurysm wall composition suggests lateral sides to be more rupture prone
    Rob Hurks
    Department of Vascular Surgery, University Medical Center Utrecht, Utrecht, The Netherlands Department of Experimental Cardiology Laboratory, University Medical Center Utrecht, Utrecht, The Netherlands
    J Vasc Surg 55:203-9. 2012
    ..The purpose of this study was to identify local differences in inflammation and tissue degradation within the circumference of the abdominal aortic aneurysm (AAA)...
  19. doi request reprint Myocardial ischemia/reperfusion injury is mediated by leukocytic toll-like receptor-2 and reduced by systemic administration of a novel anti-toll-like receptor-2 antibody
    Fatih Arslan
    Laboratory of Experimental Cardiology, University Medical Center Utrecht, Heidelberglaan 100, 3584 CX Utrecht, The Netherlands
    Circulation 121:80-90. 2010
    ..Targeting TLR signaling may optimize reperfusion therapy and enhance cell survival and heart function after myocardial infarction. Here, we evaluated the role of TLR2 as a therapeutic target using a novel monoclonal anti-TLR2 antibody...
  20. doi request reprint The Nuclear Factor-kappa B p50 subunit is involved in flow-induced outward arterial remodeling
    J Karlijn Van Keulen
    Department Experimental Cardiology, University Medical Center Utrecht, The Netherlands
    Atherosclerosis 202:424-30. 2009
    ..The NF-kappaB subunit p50 is generally considered to be an inhibitory subunit of the NF-kappaB complex. We therefore hypothesize that NF-kappaB p50 inhibits outward arterial remodeling...
  21. doi request reprint Arterial occlusion induces systemic changes in leucocyte composition
    René Haverslag
    Laboratory of Experimental Cardiology, University Medical Center Utrecht, Utrecht, The Netherlands
    Eur J Clin Invest 41:943-50. 2011
    ..This study was designed to gain insight into the temporal changes in circulating and bone marrow-derived leucocyte fractions following peripheral arterial occlusion in mice...
  22. doi request reprint Transendocardial cell injection is not superior to intracoronary infusion in a porcine model of ischaemic cardiomyopathy: a study on delivery efficiency
    Tycho I G van der Spoel
    Division Heart and Lungs, Department of Cardiology, University Medical Center Utrecht, Utrecht, The Netherlands
    J Cell Mol Med 16:2768-76. 2012
    ..In addition, no differences in safety profile were observed. These results are important in view of the choice of percutaneous cell delivery modality in future clinical stem cell trials...
  23. ncbi request reprint Distinct CD44 splice variants differentially affect collateral artery growth
    Pieter T Bot
    Laboratory of Experimental Cardiology, University Medical Center Utrecht, Heidelberglaan 100, 3584 CX Utrecht, The Netherlands
    Curr Vasc Pharmacol 11:13-20. 2013
    ..As the variant exon CD44v3 binds heparan sulphate and facilitates preservation of growth factors, we hypothesized that the variably spliced exon region of CD44, especially exon CD44v3, is involved in arteriogenesis...
  24. doi request reprint Exenatide reduces infarct size and improves cardiac function in a porcine model of ischemia and reperfusion injury
    Leo Timmers
    Department of Cardiology, University of Medical Center Utrecht, UMC Utrecht, The Netherlands
    J Am Coll Cardiol 53:501-10. 2009
    ..This study sought to examine whether exenatide is capable of reducing myocardial infarct size...
  25. doi request reprint Assessment of collateral artery function and growth in a pig model of stepwise coronary occlusion
    Daphne de Groot
    UMC Utrecht, Experimental Cardiology, G02 523, Heidelberglaan 100, NL 3584 CX Utrecht, The Netherlands
    Am J Physiol Heart Circ Physiol 300:H408-14. 2011
    ....
  26. doi request reprint Inducible cardiac ischaemia is related to a decrease in the whole-blood Toll-like receptor 2 and 4 response
    Ellen H A M Elsenberg
    Laboratory of Experimental Cardiology, University Medical Centre Utrecht, Utrecht, The Netherlands
    Clin Sci (Lond) 122:527-33. 2012
    ..These results point to a regulating role of TLRs in order to prevent excessive inflammatory events known to occur during acute ischaemia...
  27. doi request reprint Toll-like receptor 2 and 4 stimulation elicits an enhanced inflammatory response in human obese patients with atherosclerosis
    Vincent P W Scholtes
    Experimental Laboratory Cardiology, Department of Microbiology, University Medical Center Utrecht, Utrecht, The Netherlands
    Clin Sci (Lond) 121:205-14. 2011
    ..In conclusion, obesity is associated with an enhanced TLR response in patients suffering from established atherosclerotic disease...
  28. doi request reprint Circulating immunoglobulins are not associated with intraplaque mast cell number and other vulnerable plaque characteristics in patients with carotid artery stenosis
    Sanne Willems
    Laboratory of Experimental Cardiology, University Medical Center Utrecht, Utrecht, The Netherlands
    PLoS ONE 9:e88984. 2014
    ..In addition, the levels were related to other vulnerable plaque characteristics and baseline clinical data...
  29. doi request reprint Mast cells in human carotid atherosclerotic plaques are associated with intraplaque microvessel density and the occurrence of future cardiovascular events
    Sanne Willems
    Experimental Cardiology Laboratory room G02 523, University Medical Centre Utrecht, Heidelberglaan 100, 3584 CX, Utrecht, The Netherlands
    Eur Heart J 34:3699-706. 2013
    ....
  30. ncbi request reprint Reduction of myocardial infarct size by human mesenchymal stem cell conditioned medium
    Leo Timmers
    Department of Cardiology, University Medical Center Utrecht, Utrecht, The Netherlands
    Stem Cell Res 1:129-37. 2007
    ....
  31. pmc Circulating biomarkers for predicting cardiovascular disease risk; a systematic review and comprehensive overview of meta-analyses
    Thijs C van Holten
    Laboratory for Clinical Chemistry and Hematology, UMC Utrecht, Utrecht, The Netherlands
    PLoS ONE 8:e62080. 2013
    ..We performed a systematic review of meta-analyses on levels of serological biomarkers for atherothrombosis to compare the relevance of the most commonly studied biomarkers...
  32. ncbi request reprint Toll-like receptor 4 mediates maladaptive left ventricular remodeling and impairs cardiac function after myocardial infarction
    Leo Timmers
    Department of Cardiology, University Medical Center, Utrecht, The Netherlands
    Circ Res 102:257-64. 2008
    ..TLR4 may therefore constitute a novel target in the treatment of ischemic heart failure...
  33. ncbi request reprint Six-month healing of the nonocclusive coronary anastomotic connector in an off-pump porcine bypass model
    David Stecher
    From the Departments of Cardiothoracic Surgery, Cardiology, and Experimental Cardiology, Heart and Lungs Division, University Medical Center Utrecht, Utrecht, The Netherlands
    Innovations (Phila) 9:130-6; discussion 136. 2014
    ..This pilot study evaluates the anastomotic healing of the Excimer Laser Assisted Nonocclusive Anastomosis coronary connector at 6 months in a porcine off-pump coronary artery bypass (OPCAB) model...
  34. doi request reprint FLow-induced PRotrusions (FLIPRs): a platelet-derived platform for the retrieval of microparticles by monocytes and neutrophils
    Claudia Tersteeg
    From the Laboratory of Clinical Chemistry and Haematology C T, H F H, R T U, C M, P G d G, M R, Laboratory of Experimental Cardiology C T, G P, I E H, and Cell Microscopy Center, Department of Cell Biology H F H, UMC Utrecht, Utrecht, The Netherlands UMR S949 INSERM, EFS Alsace, Universite de Strasbourg, Strasbourg, France A E, C G Department of Clinical Chemistry, AMC Amsterdam, Amsterdam, The Netherlands R N and Department of Biochemistry, University of Cambridge, Cambridge, United Kingdom R W F
    Circ Res 114:780-91. 2014
    ..Platelets are the most important cells in the primary prevention of blood loss after injury. In addition, platelets are at the interface between circulating leukocytes and the (sub)endothelium regulating inflammatory responses...
  35. doi request reprint Toll-like receptor 2 and 4 response and expression on monocytes decrease rapidly in patients undergoing arterial surgery and are related to preoperative smoking
    Dik Versteeg
    Experimental Cardiology Laboratory, University Medical Center Utrecht, Utrecht, The Netherlands
    Shock 31:21-7. 2009
    ..These results point to a significant role for TLRs in the induction of postoperative immune tolerance. Furthermore, smoking is negatively related to baseline TLR response...
  36. doi request reprint A fibronectin-fibrinogen-tropoelastin coating reduces smooth muscle cell growth but improves endothelial cell function
    Claudia Tersteeg
    Department of Experimental Cardiology, UMC Utrecht, Utrecht, The Netherlands
    J Cell Mol Med 16:2117-26. 2012
    ..These data suggest that coating a mixture of fibronectin/fibrinogen/tropoelastin on a stent may promote reendothelialization, while keeping unfavourable processes such as restenosis and procoagulant activity limited...
  37. ncbi request reprint Biobanks and the search for predictive biomarkers of local and systemic outcome in atherosclerotic disease
    Rob Hurks
    Experimental Cardiology Laboratory, Suite G02 523, Heidelberglaan 100, 3584CX Utrecht, The Netherlands
    Thromb Haemost 101:48-54. 2009
    ..The search for the plaque protein signature that is predictive for adverse events might enable patient stratification that will allow individualized tailor made medicine and subsequently guide the choice for therapeutic interventions...
  38. ncbi request reprint The multifaceted functions of CXCL10 in cardiovascular disease
    Pleunie van den Borne
    Laboratory of Experimental Cardiology, University Medical Center Utrecht, P O Box 85500, 3508 GA, Utrecht, The Netherlands
    Biomed Res Int 2014:893106. 2014
    ..Furthermore, CXCL10 as a possible biomarker in CVD will be discussed. ..
  39. ncbi request reprint The CD200-CD200 Receptor Inhibitory Axis Controls Arteriogenesis and Local T Lymphocyte Influx
    Pleunie van den Borne
    Laboratory of Experimental Cardiology, University Medical Center, Utrecht, The Netherlands
    PLoS ONE 9:e98820. 2014
    ..Lack of CD200R signaling is accompanied by increased T lymphocyte recruitment to the collateral vasculature and results in enlargement of preexisting collateral arteries. ..
  40. doi request reprint Leukotriene B4 levels in human atherosclerotic plaques and abdominal aortic aneurysms
    Pleunie van den Borne
    Laboratory of Experimental Cardiology, University Medical Center Utrecht, Utrecht, The Netherlands
    PLoS ONE 9:e86522. 2014
    ..We hypothesized that LTB4 levels are associated with a vulnerable plaque phenotype and adverse clinical outcome. Furthermore, that LTB4 levels are associated with inflammatory AAA and adverse clinical outcome...
  41. doi request reprint Toll-like receptor 4 inhibitor TAK-242 treatment does not influence perfusion recovery in tissue ischemia
    Pleunie van den Borne
    Laboratory of Experimental Cardiology, University Medical Center Utrecht, Utrecht, the Netherlands Department of Surgery and Einthoven Laboratory of Experimental Vascular Medicine, Leiden University Medical Center, Leiden, The Netherlands and Interuniversity Cardiology Institute of the Netherlands, Utrecht, The Netherlands
    J Cardiovasc Pharmacol 63:16-22. 2014
    ..TAK-242 attenuated TLR4 responses in vivo but did not inhibit perfusion recovery in mice. In conclusion, TAK-242 does not negatively influence perfusion recovery following hind limb ischemia despite its TLR4 inhibiting properties...
  42. doi request reprint Proteomics of plaques and novel sources of potential biomarkers for atherosclerosis
    Onno B Bleijerveld
    Laboratory of Experimental Cardiology, University Medical Center Utrecht, Utrecht, The Netherlands
    Proteomics Clin Appl 7:490-503. 2013
    ....
  43. pmc In-vivo validation of a new non-invasive continuous ventricular stroke volume monitoring system in an animal model
    Maurits K Konings
    Department of Medical Technology and Clinical Physics, University Medical Center Utrecht, 100 Heidelberglaan, Utrecht 3584 CX, The Netherlands
    Crit Care 15:R165. 2011
    ..A prototype using this new method was built (the hemologic cardiac profiler, HCP) and validated against a reference method in a pig model during variations in cardiac output...
  44. doi request reprint Impaired recruitment of HHT-1 mononuclear cells to the ischaemic heart is due to an altered CXCR4/CD26 balance
    Simone Post
    Department of Cardiology, Division Heart and Lung, UMCU, Utrecht, The Netherlands
    Cardiovasc Res 85:494-502. 2010
    ..Stromal cell-derived factor-1alpha (SDF-1alpha) and the chemokine receptor CXCR4 are crucial for homing and negatively influenced by CD26. The aim of this study was to gain insight into the impaired homing of HHT1-MNCs...
  45. doi request reprint Insights into mechanisms behind arteriogenesis: what does the future hold?
    Melany C van Oostrom
    Experimental Cardiology, University Medical Center Utrecht, 3584 CX Utrecht, Heidelberglaan 100, The Netherlands
    J Leukoc Biol 84:1379-91. 2008
    ..Furthermore, individual differences in the arteriogenic response will be considered, in light of the effect this will have on the success of therapeutic strategies to improve blood flow to ischemic tissue...
  46. ncbi request reprint The nonocclusive laser-assisted coronary anastomotic connector in an off-pump porcine bypass model
    David Stecher
    Department of Cardiothoracic Surgery, University Medical Center Utrecht, Utrecht, The Netherlands Electronic address
    J Thorac Cardiovasc Surg 147:1390-1397.e2. 2014
    ....
  47. doi request reprint Deep proteome profiling of circulating granulocytes reveals bactericidal/permeability-increasing protein as a biomarker for severe atherosclerotic coronary stenosis
    Onno B Bleijerveld
    Biomolecular Mass Spectrometry and Proteomics, Bijvoet Center for Biomolecular Research and Utrecht Institute of Pharmaceutical Sciences, Utrecht University and Netherlands Proteomics Centre, Utrecht, The Netherlands
    J Proteome Res 11:5235-44. 2012
    ..Our data reveal bactericidal/permeability-increasing protein (BPI) as a promising biomarker for severe atherosclerotic coronary stenosis, being down-regulated in circulating granulocytes of CTO patients...
  48. doi request reprint Endothelial progenitor cell levels in obese men with the metabolic syndrome and the effect of simvastatin monotherapy vs. simvastatin/ezetimibe combination therapy
    Peter E Westerweel
    Department of Vascular Medicine, University Medical Center Utrecht, Utrecht, The Netherlands
    Eur Heart J 29:2808-17. 2008
    ..Second, we evaluated the effect on EPC levels of two lipid-lowering treatments...
  49. ncbi request reprint G-CSF administration after myocardial infarction in mice attenuates late ischemic cardiomyopathy by enhanced arteriogenesis
    Elisabeth Deindl
    Ludwig Maximilians University, Klinikum Grosshadern, Medical Department I, Marchioninistr 15, D 81377 Munich, Germany
    FASEB J 20:956-8. 2006
    ..5 vs. 17.2%). Our results demonstrate that G-CSF administration after MI stimulates arteriogenesis and attenuates ischemic cardiomyopathy after MI...
  50. ncbi request reprint Something is rotten in the state of angiogenesis -- H2S as gaseous stimulator of angiogenesis
    Imo E Hoefer
    Cardiovasc Res 76:1-2. 2007
  51. ncbi request reprint Arteriogenesis proceeds via ICAM-1/Mac-1- mediated mechanisms
    Imo E Hoefer
    Research Group for Experimental and Clinical Arteriogenesis at the Department of Cardiology, University of Freiburg, Freiburg, Germany
    Circ Res 94:1179-85. 2004
    ....
  52. ncbi request reprint Arteriogenesis depends on circulating monocytes and macrophage accumulation and is severely depressed in op/op mice
    Caroline E Bergmann
    Research Group for Experimental and Clinical Arteriogenesis, Freiberg, Germany
    J Leukoc Biol 80:59-65. 2006
    ..This study provides additional evidence for the preeminent role of monocytes/macrophages during arteriogenesis in a genuine model of monocyte deficiency, i.e., without pharmacological intervention...
  53. ncbi request reprint A new intra-arterial delivery platform for pro-arteriogenic compounds to stimulate collateral artery growth via transforming growth factor-beta1 release
    Sebastian Grundmann
    Department of Cardiology, AMC, University of Amsterdam, Amsterdam, The Netherlands
    J Am Coll Cardiol 50:351-8. 2007
    ..The purpose of this study was to develop a cytokine-eluting stent to stimulate collateral artery growth (arteriogenesis) in the peripheral circulation of the rabbit via local transforming growth factor (TGF)-beta1 release...
  54. ncbi request reprint Differential effects of MCP-1 and leptin on collateral flow and arteriogenesis
    Stephan H Schirmer
    Research Group for Experimental and Clinical Arteriogenesis, Department of Internal Medicine III Cardiology and Angiology, University Hospital Freiburg, Breisacher Strasse 66 ZKF, D 79106 Freiburg, Germany
    Cardiovasc Res 64:356-64. 2004
    ....
  55. ncbi request reprint Leukocyte subpopulations and arteriogenesis: specific role of monocytes, lymphocytes and granulocytes
    Imo E Hoefer
    Research Group for Experimental and Clinical Arteriogenesis, Department of Cardiology, University of Freiburg, Germany
    Atherosclerosis 181:285-93. 2005
    ..The role of these two cell types in arteriogenesis remains yet to be clarified, which was the aim of the current study...
  56. ncbi request reprint Experimental models of arteriogenesis: differences and implications
    Imo E Hoefer
    Department of Experimental Cardiology, UMC, University of Utrecht, The Netherlands
    Lab Anim (NY) 35:36-44. 2006
    ....
  57. ncbi request reprint Direct evidence for tumor necrosis factor-alpha signaling in arteriogenesis
    Imo E Hoefer
    Department of Cardiology, University of Freiburg, Germany
    Circulation 105:1639-41. 2002
    ..We hypothesized that arteriogenesis is reduced in mice lacking functional TNF-alpha or p55 receptor. To test this hypothesis, we developed a novel microsphere-based murine model of hindlimb perfusion measurement...