W Antoinette Groenewegen

Summary

Affiliation: University Medical Center Utrecht
Country: The Netherlands

Publications

  1. ncbi A novel LQT3 mutation implicates the human cardiac sodium channel domain IVS6 in inactivation kinetics
    W Antoinette Groenewegen
    Department of Medical Physiology, University Medical Center Utrecht, P O Box 85060, 3508 AB, Utrecht, The Netherlands
    Cardiovasc Res 57:1072-8. 2003
  2. ncbi Cx40 polymorphism in human atrial fibrillation
    Richard N W Hauer
    University Medical Center, Utrecht, The Netherlands
    Adv Cardiol 42:284-91. 2006
  3. ncbi Polymorphisms in human connexin40 gene promoter are associated with increased risk of hypertension in men
    Mehran Firouzi
    Department of Medical Physiology, University Medical Center, Utrecht, The Netherlands
    J Hypertens 24:325-30. 2006
  4. ncbi Na+ channel mutation leading to loss of function and non-progressive cardiac conduction defects
    Lucas J Herfst
    Department of Medical Physiology, University Medical Center, Universiteitsweg 100, 3584CG, The, Utrecht, Netherlands
    J Mol Cell Cardiol 35:549-57. 2003
  5. ncbi A cardiac sodium channel mutation cosegregates with a rare connexin40 genotype in familial atrial standstill
    W Antoinette Groenewegen
    Department of Medical Physiology, University Medical Center, Utrecht, The Netherlands
    Circ Res 92:14-22. 2003
  6. ncbi Association of human connexin40 gene polymorphisms with atrial vulnerability as a risk factor for idiopathic atrial fibrillation
    Mehran Firouzi
    Department of Medical Physiology, University Medical Center Utrecht, The Netherlands
    Circ Res 95:e29-33. 2004
  7. ncbi The human Cx40 promoter polymorphism -44G-->A differentially affects transcriptional regulation by Sp1 and GATA4
    Mehran Firouzi
    Department of Medical Physiology, University Medical Center Utrecht, Yalelaan 50, 3584 CM Utrecht, The Netherlands
    Biochim Biophys Acta 1759:491-6. 2006
  8. doi Functional analysis of novel KCNQ2 mutations found in patients with Benign Familial Neonatal Convulsions
    Linda Volkers
    Complex Genetics Section, DBG Department of Medical Genetics, University Medical Center Utrecht, The Netherlands
    Neurosci Lett 462:24-9. 2009
  9. doi Heterogeneous Connexin43 distribution in heart failure is associated with dispersed conduction and enhanced susceptibility to ventricular arrhythmias
    Mohamed Boulaksil
    Interuniversity Cardiology Institute of The Netherlands, Utrecht, The Netherlands
    Eur J Heart Fail 12:913-21. 2010
  10. ncbi Compound heterozygosity for mutations (W156X and R225W) in SCN5A associated with severe cardiac conduction disturbances and degenerative changes in the conduction system
    Connie R Bezzina
    Experimental and Molecular Cardiology Group, Academic Medical Center, Amsterdam, The Netherlands
    Circ Res 92:159-68. 2003

Collaborators

Detail Information

Publications11

  1. ncbi A novel LQT3 mutation implicates the human cardiac sodium channel domain IVS6 in inactivation kinetics
    W Antoinette Groenewegen
    Department of Medical Physiology, University Medical Center Utrecht, P O Box 85060, 3508 AB, Utrecht, The Netherlands
    Cardiovasc Res 57:1072-8. 2003
    ..The Long QT3 syndrome is associated with mutations in the cardiac sodium channel gene SCN5A...
  2. ncbi Cx40 polymorphism in human atrial fibrillation
    Richard N W Hauer
    University Medical Center, Utrecht, The Netherlands
    Adv Cardiol 42:284-91. 2006
    ..Reentry is promoted by spatial dispersion of refractoriness that can be expressed as a coefficient of dispersion (CD)...
  3. ncbi Polymorphisms in human connexin40 gene promoter are associated with increased risk of hypertension in men
    Mehran Firouzi
    Department of Medical Physiology, University Medical Center, Utrecht, The Netherlands
    J Hypertens 24:325-30. 2006
    ..In the present study, we examined the hypothesis that these polymorphic variants are associated with hypertension and that they interact with blood pressure in healthy individuals...
  4. ncbi Na+ channel mutation leading to loss of function and non-progressive cardiac conduction defects
    Lucas J Herfst
    Department of Medical Physiology, University Medical Center, Universiteitsweg 100, 3584CG, The, Utrecht, Netherlands
    J Mol Cell Cardiol 35:549-57. 2003
    ....
  5. ncbi A cardiac sodium channel mutation cosegregates with a rare connexin40 genotype in familial atrial standstill
    W Antoinette Groenewegen
    Department of Medical Physiology, University Medical Center, Utrecht, The Netherlands
    Circ Res 92:14-22. 2003
    ..We propose that, although the functional effect of each genetic change is relatively benign, the combined effect of genetic changes eventually progresses to total AS...
  6. ncbi Association of human connexin40 gene polymorphisms with atrial vulnerability as a risk factor for idiopathic atrial fibrillation
    Mehran Firouzi
    Department of Medical Physiology, University Medical Center Utrecht, The Netherlands
    Circ Res 95:e29-33. 2004
    ..031; odds ratios 5.3 and 6.2). This study provides strong evidence linking Cx40 polymorphisms to enhanced atrial vulnerability and increased risk of AF. The full text of this article is available online at http://circres.ahajournals.org...
  7. ncbi The human Cx40 promoter polymorphism -44G-->A differentially affects transcriptional regulation by Sp1 and GATA4
    Mehran Firouzi
    Department of Medical Physiology, University Medical Center Utrecht, Yalelaan 50, 3584 CM Utrecht, The Netherlands
    Biochim Biophys Acta 1759:491-6. 2006
    ....
  8. doi Functional analysis of novel KCNQ2 mutations found in patients with Benign Familial Neonatal Convulsions
    Linda Volkers
    Complex Genetics Section, DBG Department of Medical Genetics, University Medical Center Utrecht, The Netherlands
    Neurosci Lett 462:24-9. 2009
    ....
  9. doi Heterogeneous Connexin43 distribution in heart failure is associated with dispersed conduction and enhanced susceptibility to ventricular arrhythmias
    Mohamed Boulaksil
    Interuniversity Cardiology Institute of The Netherlands, Utrecht, The Netherlands
    Eur J Heart Fail 12:913-21. 2010
    ..To investigate determinants of the increased arrhythmogenic susceptibility, we studied cardiac remodelling and arrhythmogenicity in CHF patients and in a mouse model of chronic pressure overload...
  10. ncbi Compound heterozygosity for mutations (W156X and R225W) in SCN5A associated with severe cardiac conduction disturbances and degenerative changes in the conduction system
    Connie R Bezzina
    Experimental and Molecular Cardiology Group, Academic Medical Center, Amsterdam, The Netherlands
    Circ Res 92:159-68. 2003
    ..The morphological changes within the heart of the deceased sibling may have occurred secondary to the Na+ channel abnormality and contributed to the severity of the disorder in this individual...
  11. ncbi Congenital atrial standstill associated with coinheritance of a novel SCN5A mutation and connexin 40 polymorphisms
    Naomasa Makita
    Department of Cardiovascular Medicine, Hokkaido University Graduate School of Medicine, Sapporo, Japan
    Heart Rhythm 2:1128-34. 2005
    ..Incomplete penetrance observed in atrial standstill has been attributed in part to the digenic inheritance of polymorphisms in the atrial-specific gap junction connexin 40 (Cx40) in conjunction with an SCN5A mutation...