D Grobbee

Summary

Affiliation: University Medical Center
Country: The Netherlands

Publications

  1. ncbi Spurious systolic hypertension in young adults; prevalence of high brachial systolic blood pressure and low central pressure and its determinants
    Hans T Hulsen
    Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, The Netherlands
    J Hypertens 24:1027-32. 2006
  2. ncbi Implications of trial results: the potentially misleading notions of number needed to treat and average duration of life gained
    J Lubsen
    SOCAR Research SA, Nyon, Switzerland
    Lancet 356:1757-9. 2000
  3. ncbi Atherosclerotic disease regression with statins: studies using vascular markers
    Diederick E Grobbee
    Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, HP D01 335, P O Box 85500, Utrecht 3508 GA, The Netherlands
    Int J Cardiol 96:447-59. 2004
  4. ncbi Epidemiology in the right direction: the importance of descriptive research
    Diederick E Grobbee
    Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, The Netherlands
    Eur J Epidemiol 19:741-4. 2004
  5. ncbi Statin treatment and progression of atherosclerotic plaque burden
    Diederick E Grobbee
    Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, The Netherlands
    Drugs 63:893-911. 2003
  6. ncbi [Possibilities and limitations of genetic research; an advisory report from the Advisory Council on Health Research]
    D E Grobbee
    Universitair Medisch Centrum Utrecht, Julius Centrum voor Gezondheidswetenschappen en Eerstelijnsgeneeskunde, Postbus 85 500, 3508 GA Utrecht
    Ned Tijdschr Geneeskd 146:1571-3. 2002
  7. pmc Cardiovascular mortality in Dutch men during 1996 European football championship: longitudinal population study
    D R Witte
    Julius Centre for General Practice and Patient Oriented Research, University Medical Centre Utrecht, Huispostnummer D01 335, 3584 CX Utrecht, Netherlands
    BMJ 321:1552-4. 2000
  8. ncbi Use of hormones in the menopausal transition period in the Netherlands between 1993 and 1997
    Franzel J B van Duijnhoven
    Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, The Netherlands
    Maturitas 53:462-75. 2006
  9. ncbi Heart disease risk determines menopausal age rather than the reverse
    Helen S Kok
    Julius Center for Health Sciences and Primary Care, Utrecht University, Utrecht, The Netherlands
    J Am Coll Cardiol 47:1976-83. 2006
  10. ncbi Postmenopausal status and early menopause as independent risk factors for cardiovascular disease: a meta-analysis
    Femke Atsma
    Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, The Netherlands
    Menopause 13:265-79. 2006

Collaborators

Detail Information

Publications64

  1. ncbi Spurious systolic hypertension in young adults; prevalence of high brachial systolic blood pressure and low central pressure and its determinants
    Hans T Hulsen
    Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, The Netherlands
    J Hypertens 24:1027-32. 2006
    ..To investigate the prevalence and determinants of spurious systolic hypertension (SSH) in a population-based sample of young adults and estimate their 20-year risk of coronary heart disease...
  2. ncbi Implications of trial results: the potentially misleading notions of number needed to treat and average duration of life gained
    J Lubsen
    SOCAR Research SA, Nyon, Switzerland
    Lancet 356:1757-9. 2000
    ..He must justly represent the known risks and benefits such that his patient can make a reasonably Informed choice. Should the physician cite the number needed to treat or the average duration of life gained to clarify his explanations?..
  3. ncbi Atherosclerotic disease regression with statins: studies using vascular markers
    Diederick E Grobbee
    Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, HP D01 335, P O Box 85500, Utrecht 3508 GA, The Netherlands
    Int J Cardiol 96:447-59. 2004
    ..Hence, imaging studies support early intervention with statins in coronary heart disease patients, irrespective of lipid level...
  4. ncbi Epidemiology in the right direction: the importance of descriptive research
    Diederick E Grobbee
    Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, The Netherlands
    Eur J Epidemiol 19:741-4. 2004
  5. ncbi Statin treatment and progression of atherosclerotic plaque burden
    Diederick E Grobbee
    Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, The Netherlands
    Drugs 63:893-911. 2003
    ....
  6. ncbi [Possibilities and limitations of genetic research; an advisory report from the Advisory Council on Health Research]
    D E Grobbee
    Universitair Medisch Centrum Utrecht, Julius Centrum voor Gezondheidswetenschappen en Eerstelijnsgeneeskunde, Postbus 85 500, 3508 GA Utrecht
    Ned Tijdschr Geneeskd 146:1571-3. 2002
    ..The Netherlands Federation of Societies for Medical Research has produced guidelines which researchers should follow when carrying out their research...
  7. pmc Cardiovascular mortality in Dutch men during 1996 European football championship: longitudinal population study
    D R Witte
    Julius Centre for General Practice and Patient Oriented Research, University Medical Centre Utrecht, Huispostnummer D01 335, 3584 CX Utrecht, Netherlands
    BMJ 321:1552-4. 2000
    ..To investigate whether an important football match increases stress to such an extent that it triggers acute myocardial infarction and stroke...
  8. ncbi Use of hormones in the menopausal transition period in the Netherlands between 1993 and 1997
    Franzel J B van Duijnhoven
    Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, The Netherlands
    Maturitas 53:462-75. 2006
    ..To describe the patterns and to assess the indicators of hormone use during the menopausal transition period in a Dutch population...
  9. ncbi Heart disease risk determines menopausal age rather than the reverse
    Helen S Kok
    Julius Center for Health Sciences and Primary Care, Utrecht University, Utrecht, The Netherlands
    J Am Coll Cardiol 47:1976-83. 2006
    ..The purpose of this study was to investigate whether a harmful cardiovascular risk profile accelerates menopause...
  10. ncbi Postmenopausal status and early menopause as independent risk factors for cardiovascular disease: a meta-analysis
    Femke Atsma
    Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, The Netherlands
    Menopause 13:265-79. 2006
    ..The aim was to obtain valid estimates of the cardiovascular disease risk associated with postmenopausal status and early menopause...
  11. ncbi Influence of estrogen receptor alpha and progesterone receptor polymorphisms on the effects of hormone therapy on mammographic density
    Franzel J B van Duijnhoven
    Julius Center for Health Sciences and Primary Care, University Medical Center, Utrecht, Mail drop Str 6 131, P O Box 85500, 3508 GA Utrecht, The Netherlands
    Cancer Epidemiol Biomarkers Prev 15:462-7. 2006
    ..In conclusion, our results suggest that specific polymorphisms in the ESR1 and PGR genes may make women more susceptible to the effects of hormone therapy use on mammographic density...
  12. ncbi Cumulative genetic defects in carcinogen metabolism may increase breast cancer risk (The Netherlands)
    Olga L van der Hel
    Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, PO Box 85500, 3508 GA Utrecht, The Netherlands
    Cancer Causes Control 16:675-81. 2005
    ..45 (95% CI 1.24-4.86), compared to women with zero putative at risk genotypes. In conclusion, the results of this study suggest that presence of three or more putative at risk genotypes increases breast cancer risk...
  13. ncbi Relations between body composition, functional and hormonal parameters and quality of life in healthy postmenopausal women
    Corinne E I Lebrun
    Julius Center for Health Sciences and Primary Care, University Medical Center, Utrecht, The Netherlands Department of Internal Medicine, Erasmus University Medical Center Rotterdam, The Netherlands
    Maturitas 55:82-92. 2006
    ..To investigate whether body composition, functional status and serum hormone levels are associated with quality of life in healthy postmenopausal women...
  14. ncbi Lower birth weight predicts metabolic syndrome in young adults: the Atherosclerosis Risk in Young Adults (ARYA)-study
    Made K Ramadhani
    Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, P O Box 85500, 3508 GA Utrecht, The Netherlands
    Atherosclerosis 184:21-7. 2006
    ..To study the relationship between intrauterine growth and the metabolic syndrome, particularly fasting serum lipids in young adulthood...
  15. ncbi The 1944-1945 Dutch famine and subsequent overall cancer incidence
    Sjoerd G Elias
    Julius Center for Health Sciences and Primary Care, Room Str 6 119, University Medical Center Utrecht, P O Box 85060, 3508 AB Utrecht, The Netherlands
    Cancer Epidemiol Biomarkers Prev 14:1981-5. 2005
    ..In conclusion, we found no indications that this brief famine has affected overall cancer risk, exclusive of breast cancer. Counteracting increased caloric intake following the famine, however, may have obscured any relation...
  16. ncbi Noninvasive arterial measurements of vascular damage in healthy young adults: relation to coronary heart disease risk
    Marijke J C A van Trijp
    Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, and Dept of Internal Medicine, St Antonius Hospital, Nieuwegein, The Netherlands
    Ann Epidemiol 16:71-7. 2006
    ..Our aim was to study whether AIx is related to coronary heart disease (CHD) risk and to compare the strength of the relations of AIx, PWV, and CIMT with cardiovascular risk in healthy young adults...
  17. ncbi Measurements of breast density: no ratio for a ratio
    Gerco Haars
    Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Stratenum, P O Box 85500, 3508 GA Utrecht, The Netherlands
    Cancer Epidemiol Biomarkers Prev 14:2634-40. 2005
    ..Although relative density is a relevant prognostic factor, inferences about the etiology of breast density should be made on the basis of absolute measures...
  18. ncbi The estrogen receptor alpha gene and breast cancer risk (The Netherlands)
    N Charlotte Onland-Moret
    Julius Center for Health Sciences and Primary Care, UMC Utrecht, Room St 6 131, PO Box 85500, 3508, GA Utrecht, The Netherlands
    Cancer Causes Control 16:1195-202. 2005
    ..The selection of these polymorphisms was based on previously published associations with osteoporosis and spontaneous abortions...
  19. ncbi Carotid intima-media thickness and the risk of new vascular events in patients with manifest atherosclerotic disease: the SMART study
    Joke M Dijk
    Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Huispostnummer Str 6 131, PO Box 85060, 3508 BA Utrecht, The Netherlands
    Eur Heart J 27:1971-8. 2006
    ..Currently, little is known about the relationship between CIMT and new vascular events in patients with manifest arterial disease. We aimed to assess the strength of this relationship...
  20. ncbi Depression and cardiovascular mortality: a role for n-3 fatty acids?
    Marjolein H Kamphuis
    Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, Netherlands
    Am J Clin Nutr 84:1513-7. 2006
    ..Recent studies indicate that depression plays an important role in the occurrence of cardiovascular diseases (CVDs). The underlying mechanisms are not well understood...
  21. pmc Peroxisome proliferator-activated receptor gamma-2 P12A polymorphism and risk of acute myocardial infarction, coronary heart disease and ischemic stroke: a case-cohort study and meta-analyses
    Mohammad Hadi Zafarmand
    Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Heidelberglaan 100, Str 6 131, 3584 CX, Utrecht, The Netherlands
    Vasc Health Risk Manag 4:427-36. 2008
    ..Yet, the risk relation has not been confirmed, and data on ischemic stroke (IS) is scarce. We therefore investigated the role of this polymorphism on occurrence of AMI, coronary heart disease (CHD) and IS...
  22. doi Variations in the uncoupling protein-3 gene are associated with specific obesity phenotypes
    Annet F M van Abeelen
    Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Room Str 6 131, PO Box 85500, 3508 GA Utrecht, The Netherlands
    Eur J Endocrinol 158:669-76. 2008
    ..Single nucleotide polymorphisms (SNPs) in UCP-3 might result in a reduced function or expression of UCP-3 and therefore lead to an increased capacity to store energy as fat...
  23. doi Pulse pressure amplification and risk of cardiovascular disease
    Marie Elise Nijdam
    Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, The Netherlands
    Am J Hypertens 21:388-92. 2008
    ..The purpose of this study was to investigate the relationship between PPA and cardiovascular risk factors and cardiovascular risk in a population-based sample of 40- to 80-year old men...
  24. doi Elevated blood pressure and electrocardiographic frontal T axis and spatial QRS-T angle changes in postmenopausal women
    Femke Atsma
    Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, The Netherlands
    J Electrocardiol 41:360-4. 2008
    ..We determined whether increased blood pressure is a risk factor for changes in these parameters in postmenopausal women free of left ventricular hypertrophy...
  25. doi Effect of testosterone supplementation on functional mobility, cognition, and other parameters in older men: a randomized controlled trial
    Marielle H Emmelot-Vonk
    Department of Geriatric Medicine, University Medical Center Utrecht, Utrecht, The Netherlands
    JAMA 299:39-52. 2008
    ..Serum testosterone levels decline significantly with aging. Testosterone supplementation to older men might beneficially affect the aging processes...
  26. ncbi No increased incidence of diabetes in antidepressant users
    Mirjam J Knol
    Julius Center for Health Sciences and Primary Care, Utrecht, The Netherlands
    Int Clin Psychopharmacol 22:382-6. 2007
    ..12-1.68) for AD and BD users compared with no AD and no BD users. We did not find an increased risk of diabetes in individuals using ADs. The association between BD use and diabetes was partly explained by chronic somatic comorbidity...
  27. pmc Sodium and potassium intake and risk of cardiovascular events and all-cause mortality: the Rotterdam Study
    Johanna M Geleijnse
    Division of Human Nutrition, Wageningen University, PO Box 8129, 6700 EV Wageningen, The Netherlands
    Eur J Epidemiol 22:763-70. 2007
    ..We examined sodium and potassium intake in relation to cardiovascular disease (CVD) and mortality in an unselected older population...
  28. ncbi High dietary glycemic load and glycemic index increase risk of cardiovascular disease among middle-aged women: a population-based follow-up study
    Joline W J Beulens
    Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, The Netherlands
    J Am Coll Cardiol 50:14-21. 2007
    ..The goal of this work was to assess whether high dietary glycemic load and glycemic index are associated with an increased risk of cardiovascular disease (CVD)...
  29. ncbi Dietary phytoestrogen intake and cognitive function in older women
    Sanne Kreijkamp-Kaspers
    Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, The Netherlands
    J Gerontol A Biol Sci Med Sci 62:556-62. 2007
    ..Aging is associated with a decline in cognitive function; we explored the possible influence of dietary phytoestrogens on this decline...
  30. ncbi Effect of rosuvastatin on progression of carotid intima-media thickness in low-risk individuals with subclinical atherosclerosis: the METEOR Trial
    John R Crouse
    Department of Medicine, Wake Forest University, Winston Salem, NC 27157, USA
    JAMA 297:1344-53. 2007
    ..Atherosclerosis is often advanced before symptoms appear and it is not clear whether treatment is beneficial in middle-aged individuals with a low Framingham risk score (FRS) and mild to moderate subclinical atherosclerosis...
  31. ncbi Carotid intima-media thickness in low-risk individuals with asymptomatic atherosclerosis: baseline data from the METEOR study
    John R Crouse
    Wake Forest University, Winston Salem, NC 27157, USA
    Curr Med Res Opin 23:641-8. 2007
    ..We present baseline data from the METEOR study, a randomized, placebo-controlled trial evaluating the efficacy of rosuvastatin 40 mg on changes in CIMT. We set out to compare differences in CIMT between several subgroups of individuals...
  32. ncbi Analysis of case-cohort data: a comparison of different methods
    N Charlotte Onland-Moret
    Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Room Str 6 131, PO Box 85500, 3508 GA Utrecht, The Netherlands
    J Clin Epidemiol 60:350-5. 2007
    ..However, adaptation of the model is necessary because of the sampling. We compared three methods that were proposed in the literature, which differ in weighting of study subjects: Prentice's, Barlow's, and Self and Prentice's method...
  33. ncbi Low levels of adiponectin predict worsening of arterial morphology and function
    Stefan Störk
    Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, The Netherlands
    Atherosclerosis 194:e147-53. 2007
    ..We conclude that low levels of adiponectin are associated with adverse changes in morphology and function of central arteries over time independently of other cardiovascular risk factors in postmenopausal non-diabetic women...
  34. ncbi Common genetic variations in CCK, leptin, and leptin receptor genes are associated with specific human eating patterns
    Mariken de Krom
    Department of Pharmacology and Anatomy, Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, The Netherlands
    Diabetes 56:276-80. 2007
    ..In conclusion, we identified common allelic variants specifically associated with distinctly different eating patterns, namely extreme snacking behavior or excessive portion size...
  35. ncbi Serum ferritin is a risk factor for stroke in postmenopausal women
    Daphne L van der A
    Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, HP Str 6 131, PO Box 85500, 3508 GA Utrecht, The Netherlands
    Stroke 36:1637-41. 2005
    ..Iron is an essential element for the human body. It has, however, been suggested that excessive iron stores may increase the risk of vascular disease. So far, epidemiologic studies on stroke are sparse...
  36. ncbi Is the association between flow-mediated dilation and cardiovascular risk limited to low-risk populations?
    Daniel R Witte
    Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Heiderberglaan 100, 3584 CX Utrecht, The Netherlands
    J Am Coll Cardiol 45:1987-93. 2005
    ..The aim of this research was to study whether the relation between endothelial function measured by flow-mediated dilation (FMD) of the brachial artery and cardiovascular risk factors is affected by the baseline cardiovascular risk...
  37. ncbi Dietary phytoestrogens and breast cancer risk
    Lital Keinan-Boker
    Julius Center for Health Sciences and Primary Care, University Medical Center, Utrecht, Netherlands
    Am J Clin Nutr 79:282-8. 2004
    ..A high intake of phytoestrogens, particularly isoflavones, has been suggested to decrease breast cancer risk. Results from human studies are inconclusive...
  38. ncbi Alcohol consumption in relation to aortic stiffness and aortic wave reflections: a cross-sectional study in healthy postmenopausal women
    Aafje Sierksma
    Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, The Netherlands
    Arterioscler Thromb Vasc Biol 24:342-8. 2004
    ..Moderate alcohol consumption has been postulated to be cardioprotective. Such an effect might be reflected in large-artery properties, such as arterial stiffness and wave reflections...
  39. ncbi Carotid intima-media thickness measurements in intervention studies: design options, progression rates, and sample size considerations: a point of view
    Michiel L Bots
    Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, The Netherlands
    Stroke 34:2985-94. 2003
    ..We discuss the various options and provide a pooled estimate of CIMT progression. In addition, we quantify the effect of these choices on the sample size for a RCT...
  40. ncbi Adolescent blood pressure and blood pressure tracking into young adulthood are related to subclinical atherosclerosis: the Atherosclerosis Risk in Young Adults (ARYA) study
    Lydia E Vos
    Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, The Netherlands
    Am J Hypertens 16:549-55. 2003
    ..Our aim was to study the relationships of adolescent BP and tracking of BP into young adulthood with subclinical atherosclerosis, as assessed by carotid intima-media thickness (CIMT), at the age of 28 years...
  41. ncbi NAT2 slow acetylation and GSTM1 null genotypes may increase postmenopausal breast cancer risk in long-term smoking women
    Olga L van der Hel
    Julius Center for Health Sciences and Primary Care, University Medical Center, Utrecht, The Netherlands
    Pharmacogenetics 13:399-407. 2003
    ....
  42. ncbi Serum insulin-like growth factor binding protein-2 levels as an indicator of functional ability in elderly men
    Annewieke W van den Beld
    Department of Internal Medicine III, Room D4, Erasmus University Medical Center, 40 Dr Molewaterplein, 3015 GD Rotterdam, The Netherlands
    Eur J Endocrinol 148:627-34. 2003
    ....
  43. ncbi Does the beneficial effect of HRT on endothelial function depend on lipid changes
    Marlies E Ossewaarde
    Julius Centre for Health Sciences and Primary Care, University Medical Centre Utrecht HP D01 335, Heidelberglaan 100, 3584 CX Utrecht, Netherlands
    Maturitas 45:47-54. 2003
    ....
  44. ncbi Plasma and urinary sex hormones are differently related to lipids in healthy postmenopausal women
    Marlies E Ossewaarde
    Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Heidelberglaan 100, 3584 CX, Utrecht, The Netherlands
    Maturitas 44:181-7. 2003
    ..Endogenous sex hormones can be measured in plasma and urine. We determined the extent to which these two methods provide different information on hormonal status by relating them to lipid profile in postmenopausal women...
  45. ncbi Arterial stiffness in postmenopausal women: determinants of pulse wave velocity
    Corinne E I Lebrun
    Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht and Department of Internal Medicine, Erasmus University Medical Center Rotterdam, Rotterdam, The Netherlands
    J Hypertens 20:2165-72. 2002
    ..Increased PWV marks an increased risk of stroke, coronary heart disease, and death within 10-12 years...
  46. pmc Prospective cohort study of routine use of risk assessment scales for prediction of pressure ulcers
    Lisette Schoonhoven
    Julius Centre for Health Sciences and Primary Care, University Medical Centre Utrecht, PO Box 85500, 3508 GA, Utrecht, Netherlands
    BMJ 325:797. 2002
    ..To evaluate whether risk assessment scales can be used to identify patients who are likely to get pressure ulcers...
  47. ncbi Urinary albumin excretion predicts cardiovascular and noncardiovascular mortality in general population
    Hans L Hillege
    Trial Coordination Center, Department of Cardiology, University Hospital of Groningen, Groningen, The Netherlands
    Circulation 106:1777-82. 2002
    ..Therefore, we examined the relationship between urinary albumin excretion and all-cause mortality and mortality caused by cardiovascular (CV) disease and non-CV disease in the general population...
  48. ncbi Alcohol consumption and risk of peripheral arterial disease: the Rotterdam study
    Rozemarijn Vliegenthart
    Department of Epidemiology and Biostatistics, Erasmus University Medical School, Rotterdam, The Netherlands
    Am J Epidemiol 155:332-8. 2002
    ..65 (95% CI: 0.48, 0.87), 0.66 (95% CI: 0.42, 1.05), and 0.41 (95% CI: 0.21, 0.77), respectively. In conclusion, an inverse association between alcohol consumption and peripheral arterial disease was found in nonsmoking men and women...
  49. ncbi Breast cancer risk after caloric restriction during the 1944-1945 Dutch famine
    Sjoerd G Elias
    Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, The Netherlands
    J Natl Cancer Inst 96:539-46. 2004
    ..We examined whether caloric restriction imposed as a consequence of the 1944-1945 Dutch famine reduced the risk of breast cancer in women participating in a Dutch breast cancer screening program...
  50. ncbi GSTM1 null genotype, red meat consumption and breast cancer risk (The Netherlands)
    Olga L van der Hel
    Julius Center for Health Sciences and Primary Care, University Medical Center, Utrecht, P O Box 85500, 3508 GA Utrecht, The Netherlands
    Cancer Causes Control 15:295-303. 2004
    ..We studied whether polymorphisms in N-acetyltransferase 1 and 2 and Glutathione S-transferase M1 and T1 genes modify the association between meat consumption and breast cancer...
  51. ncbi Dietary phytoestrogens and vascular function in postmenopausal women: a cross-sectional study
    Sanne Kreijkamp-Kaspers
    Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, The Netherlands
    J Hypertens 22:1381-8. 2004
    ..To investigate the effects of low levels of intake of phytoestrogens in Western habitual diet on vascular function...
  52. ncbi Age at menopause, cause-specific mortality and total life expectancy
    Marlies E Ossewaarde
    Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, The Netherlands
    Epidemiology 16:556-62. 2005
    ..The net effect on mortality is unclear. We determined the association of age at menopause with longevity and with the balance between cardiovascular and cancer mortality...
  53. ncbi Higher dietary intake of lignans is associated with better cognitive performance in postmenopausal women
    Oscar H Franco
    Julius Center for Health Sciences and Primary Care, University Medical Center, Utrecht, The Netherlands
    J Nutr 135:1190-5. 2005
    ..02 (1.11-3.71)]. Isoflavone intake was not related to cognitive function. From our results we conclude that higher dietary intake of lignans is associated with better cognitive function in postmenopausal women...
  54. ncbi Cyp17, urinary sex steroid levels and breast cancer risk in postmenopausal women
    N Charlotte Onland-Moret
    Julius Center for Health Sciences and Primary Care, UMC Utrecht, 3508 GA Utrecht, The Netherlands
    Cancer Epidemiol Biomarkers Prev 14:815-20. 2005
    ..However, these increased sex steroid levels are not translated into an increased breast cancer risk in these women...
  55. ncbi Presence of the metabolic syndrome does not impair coronary collateral vessel formation in patients with documented coronary artery disease
    Jobien K Olijhoek
    Department of Internal Medicine, Section of Vascular Medicine, University Medical Centre Utrecht, F02 126, Heidelberglaan 100, 3584 CX Utrecht, The Netherlands
    Diabetes Care 28:683-9. 2005
    ..The aim of the present study was to determine the influence of the metabolic syndrome and insulin resistance on the presence of coronary collaterals...
  56. ncbi Prospective study on usual dietary phytoestrogen intake and cardiovascular disease risk in Western women
    Yvonne T van der Schouw
    Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Room Str 6 131, PO Box 85500, 3508 GA Utrecht, Netherlands
    Circulation 111:465-71. 2005
    ..We investigated whether habitual low phytoestrogen intake is associated with manifest cardiovascular disease risk...
  57. ncbi Randomized controlled trial of the effects of soy protein containing isoflavones on vascular function in postmenopausal women
    Sanne Kreijkamp-Kaspers
    The Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Netherlands
    Am J Clin Nutr 81:189-95. 2005
    ..The incidence of cardiovascular disease increases after menopause, possibly because of the decline in estrogen. Soy protein, a rich source of estrogen-like isoflavones, is hypothesized to improve vascular function...
  58. ncbi Dietary phytoestrogens and plasma lipids in Dutch postmenopausal women; a cross-sectional study
    Sanne Kreijkamp-Kaspers
    Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, PO Box 85500 Room D 01 335 Utrecht, GA3508 The Netherlands
    Atherosclerosis 178:95-100. 2005
    ..Little is known about the effects of intake within the range of western diets on these endpoints. Design: We conducted a population-based cross-sectional study in 301 women aged 60-75 years...
  59. ncbi Dietary intake of menaquinone is associated with a reduced risk of coronary heart disease: the Rotterdam Study
    Johanna M Geleijnse
    Department of Epidemiology and Biostatistics, Erasmus Medical Center Rotterdam, Rotterdam, The Netherlands
    J Nutr 134:3100-5. 2004
    ..71 (0.50, 1.00) and 0.48 (0.32, 0.71), respectively]. Phylloquinone intake was not related to any of the outcomes. These findings suggest that an adequate intake of menaquinone could be important for CHD prevention...
  60. ncbi Effect of soy protein containing isoflavones on cognitive function, bone mineral density, and plasma lipids in postmenopausal women: a randomized controlled trial
    Sanne Kreijkamp-Kaspers
    The Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, The Netherlands
    JAMA 292:65-74. 2004
    ..Isoflavones, estrogenlike compounds naturally occurring in plant foods, might confer positive effects with fewer adverse effects...
  61. ncbi Measuring Effects on intima media Thickness: an Evaluation Of Rosuvastatin in subclinical atherosclerosis--the rationale and methodology of the METEOR study
    John Robert Crouse
    Department of Medicine, Section on Endocrinology Metabolism, Wake Forest University School of Medicine, Medical Center Blvd, Winston Salem, NC 27157, USA
    Cardiovasc Drugs Ther 18:231-8. 2004
    ....
  62. ncbi Indicators for the total duration of premenopausal endogenous estrogen exposure in relation to BMD
    Maria L C Hagemans
    Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Room D 01 335, PO Box 85500, 3508 GA Utrecht, The Netherlands
    Hum Reprod 19:2163-9. 2004
    ..The present study investigates whether combining more information on reproductive factors is useful in estimating individual total duration of exposure to endogenous estrogens...
  63. ncbi Body mass index and short-term weight change in relation to mortality in Dutch women after age 50 y
    Shoko Maru
    Julius Center for Health Sciences and Primary Care, University Medical Center, Utrecht, Netherlands
    Am J Clin Nutr 80:231-6. 2004
    ..The question of whether weight loss increases a person's longevity is important given the high prevalence of obesity and the large number of people trying to lose weight in industrialized countries...
  64. ncbi Dietary intake of phytoestrogens is associated with a favorable metabolic cardiovascular risk profile in postmenopausal U.S.women: the Framingham study
    Miriam J J de Kleijn
    Julius Center for General Practice and Patient Oriented Research, University Medical Center, Utrecht, The Netherlands
    J Nutr 132:276-82. 2002
    ..55 points (95% CI, -0.82 to -0.28). In conclusion, high intake of phytoestrogens in postmenopausal women appears to be associated with a favorable metabolic cardiovascular risk profile...