Reinoud Gosens


Affiliation: University of Groningen
Country: The Netherlands


  1. Wu X, Van Dijk E, Bos I, Kistemaker L, Gosens R. Mouse Lung Tissue Slice Culture. Methods Mol Biol. 2019;1940:297-311 pubmed publisher
    ..Here we describe the methodology involved in preparing and culturing PCLS followed by detailed practical information about their possible applications. ..
  2. Ng Blichfeldt J, Schrik A, Kortekaas R, Noordhoek J, Heijink I, Hiemstra P, et al. Retinoic acid signaling balances adult distal lung epithelial progenitor cell growth and differentiation. EBioMedicine. 2018;36:461-474 pubmed publisher
    ..FUND: This project is funded by the Lung Foundation Netherlands (Longfonds) grant (RG, MK, JS, PSH) and W2/W3 Professorship Award by the Helmholtz Association, Berlin, Germany (MK). ..
  3. van den Berg M, Meurs H, Gosens R. Targeting arginase and nitric oxide metabolism in chronic airway diseases and their co-morbidities. Curr Opin Pharmacol. 2018;40:126-133 pubmed publisher
    ..This review focusses on the role of arginase, NOS and ADMA in co-morbidities of asthma and COPD and speculates on their possible connection. ..
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    Gosens R, Grootte Bromhaar M, Maarsingh H, ten Damme A, Meurs H, Zaagsma J, et al. Bradykinin augments EGF-induced airway smooth muscle proliferation by activation of conventional protein kinase C isoenzymes. Eur J Pharmacol. 2006;535:253-62 pubmed
    ..In addition, the results show that PKC isozyme-specificity underlies stimulus-specific differences in mitogenic capacity for bradykinin and PMA. ..
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    Gosens R, Dueck G, Rector E, Nunes R, Gerthoffer W, Unruh H, et al. Cooperative regulation of GSK-3 by muscarinic and PDGF receptors is associated with airway myocyte proliferation. Am J Physiol Lung Cell Mol Physiol. 2007;293:L1348-58 pubmed
    ..Moreover, muscarinic receptors mediate PKC-dependent GSK-3 inhibition, and this appears to be a primary mechanism underpinning augmentation of PDGF-induced cell growth. ..
  6. Kistemaker L, Gosens R. Acetylcholine beyond bronchoconstriction: roles in inflammation and remodeling. Trends Pharmacol Sci. 2015;36:164-71 pubmed publisher
  7. Gosens R, Grainge C. Bronchoconstriction and airway biology: potential impact and therapeutic opportunities. Chest. 2015;147:798-803 pubmed publisher
    ..Furthermore, we highlight potential impacts of therapies influencing mechanical forces on airway structure and function in asthma. ..
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    Gosens R, Mutawe M, Martin S, Basu S, Bos S, Tran T, et al. Caveolae and caveolins in the respiratory system. Curr Mol Med. 2008;8:741-53 pubmed
    ..We review the role of caveolae and caveolins in lung cells and discuss their involvement in cellular signaling associated with asthma, COPD, lung cancer, idiopathic pulmonary fibrosis and pulmonary vascular defects. ..
  9. Gosens R, Baarsma H, Heijink I, Oenema T, Halayko A, Meurs H, et al. De novo synthesis of {beta}-catenin via H-Ras and MEK regulates airway smooth muscle growth. FASEB J. 2010;24:757-68 pubmed publisher
    ..Gosens, R., Baarsma, H. A., Heijink, I. H., Oenema, T. A., Halayko, A. J., Meurs, H., Schmidt, M. De novo synthesis of beta-catenin via H-Ras and MEK regulates airway smooth muscle growth. ..

More Information


  1. Spanjer A, Baarsma H, Oostenbrink L, Jansen S, Kuipers C, Lindner M, et al. TGF-β-induced profibrotic signaling is regulated in part by the WNT receptor Frizzled-8. FASEB J. 2016;30:1823-35 pubmed publisher
    ..A., Oostenbrink, L. M., Jansen, S. R., Kuipers, C. C., Lindner, M., Postma, D. S., Meurs, H., Heijink, I. H., Gosens, R., Königshoff, M. TGF-β-induced profibrotic signaling is regulated in part by the WNT receptor Frizzled-8. ..
  2. Kumawat K, Koopmans T, Menzen M, Prins A, Smit M, Halayko A, et al. Cooperative signaling by TGF-β1 and WNT-11 drives sm-α-actin expression in smooth muscle via Rho kinase-actin-MRTF-A signaling. Am J Physiol Lung Cell Mol Physiol. 2016;311:L529-37 pubmed publisher
    ..The present study thus demonstrates a WNT-11-dependent Rho kinase-actin-MRTF-A signaling axis that regulates the expression of sm-α-actin in ASM cells. ..
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    Gosens R, Dueck G, Gerthoffer W, Unruh H, Zaagsma J, Meurs H, et al. p42/p44 MAP kinase activation is localized to caveolae-free membrane domains in airway smooth muscle. Am J Physiol Lung Cell Mol Physiol. 2007;292:L1163-72 pubmed
    ..This reveals that directed trafficking of plasma membrane EGFR is an essential element of signal transduction leading to p42/p44 MAP kinase activation. ..
  4. Baarsma H, Bos S, Meurs H, Visser K, Smit M, Schols A, et al. Pharmacological inhibition of GSK-3 in a guinea pig model of LPS-induced pulmonary inflammation: I. Effects on lung remodeling and pathology. Respir Res. 2013;14:113 pubmed publisher
    ..The kinase acts as a negative regulator in ?-catenin signalling and is critically involved in the smad pathway. Activation of both pathways may contribute to pulmonary features of chronic obstructive pulmonary disease (COPD)...
  5. Koopmans T, Gosens R. Revisiting asthma therapeutics: focus on WNT signal transduction. Drug Discov Today. 2018;23:49-62 pubmed publisher
    ..In this review, we revisit asthma therapeutics by examining whether WNT signalling is a valid therapeutic target for asthma. ..