- Towards a double controlled conditionally replicative adenovirus for potent and specific melanoma cell killW M Gommans
Department of Therapeutic Gene Modulation, University of Groningen A. Deusinglaan 1, Groningen, The Netherlands
J Control Release 116:e64-6. 2006
- An ex vivo human model system to evaluate specificity of replicating and non-replicating gene therapy agentsM G Rots
Department of Therapeutic Gene Modulation, Groningen University Institute for Drug Exploration, 9713 AV Groningen, The Netherlands
J Gene Med 8:35-41. 2006..We present a clinically relevant tissue slice technology to preclinically test improved vector characteristics...
- The carcinoma-specific epithelial glycoprotein-2 promoter controls efficient and selective gene expression in an adenoviral contextW M Gommans
Department of Therapeutic Gene Modulation, University Center for Pharmacy, University Groningen, Groningen, The Netherlands
Cancer Gene Ther 13:150-8. 2006..This study demonstrates the value of the EGP-2 promoter to restrict transgene expression to a broad range of tumor types, thereby preventing liver toxicity...
- Highly efficient and carcinoma-specific adenoviral replication restricted by the EGP-2 promoterW M Gommans
Department of Therapeutic Gene Modulation, Groningen University Institute for Drug Exploration, The Netherlands
J Control Release 117:1-10. 2007..This report clearly shows the potency of the EGP-2 promoter to mediate highly efficient and specific adenoviral replication for carcinoma gene therapy...