E J Giltay

Summary

Affiliation: University Medical Center
Country: The Netherlands

Publications

  1. doi Osteoporosis and vertebral fractures in men aged 60-74 years
    Morten Frost
    Department of Endocrinology, Odense University Hospital, Kloevervaenget 6, Odense 5000, Denmark
    Age Ageing 41:171-7. 2012
  2. doi Self-rated health and physician-rated health as independent predictors of mortality in elderly men
    Erik J Giltay
    Department of Psychiatry, Leiden University Medical Center, P O Box 9600, 2300 RC, Leiden, The Netherlands
    Age Ageing 41:165-71. 2012
  3. ncbi Low respiratory function increases the risk of depressive symptoms in later life in men
    Erik J Giltay
    Department of Psychiatry, Leiden University Medical Center, Leiden, 2300 RC Leiden, Netherlands
    Psychosom Med 72:53-60. 2010
  4. ncbi Psychotic symptoms in patients undergoing coronary artery bypass grafting and heart valve operation
    Erik J Giltay
    GGZ Delfland, Institute of Mental Health, P O Box 5016, 2600 GA Delft, The Netherlands
    Eur J Cardiothorac Surg 30:140-7. 2006
  5. ncbi Serum markers of brain-cell damage and C-reactive protein are unaffected by electroconvulsive therapy
    Erik J Giltay
    GGZ Delfland, Institute of Mental Health, Delft, The Netherlands
    World J Biol Psychiatry 9:231-5. 2008
  6. ncbi Lifestyle and dietary correlates of dispositional optimism in men: The Zutphen Elderly Study
    Erik J Giltay
    Department of Psychiatry, Leiden University Medical Center, Leiden, The Netherlands
    J Psychosom Res 63:483-90. 2007
  7. ncbi Effects of sex steroids on the neurotransmitter-specific aromatic amino acids phenylalanine, tyrosine, and tryptophan in transsexual subjects
    Erik J Giltay
    Department of Psychiatry, Leiden University Medical Center, Leiden, The Netherlands
    Neuroendocrinology 88:103-10. 2008
  8. ncbi Cardiovascular risk profile and subsequent disability and mental well-being: the Zutphen Elderly Study
    Erik J Giltay
    Department of Psychiatry, Leiden University Medical Center, Leiden, The Netherlands
    Am J Geriatr Psychiatry 16:874-82. 2008
  9. doi Serum cholesterol, apolipoprotein E genotype and depressive symptoms in elderly European men: the FINE study
    Erik J Giltay
    Leiden University Medical Center, Department of Psychiatry, Leiden, The Netherlands
    J Affect Disord 115:471-7. 2009
  10. doi C-reactive protein levels and ageing male symptoms in hypogonadal men treated with testosterone supplementation
    E J Giltay
    Department of Psychiatry, Leiden University Medical Center, Leiden, The Netherlands
    Andrologia 40:398-400. 2008

Detail Information

Publications68

  1. doi Osteoporosis and vertebral fractures in men aged 60-74 years
    Morten Frost
    Department of Endocrinology, Odense University Hospital, Kloevervaenget 6, Odense 5000, Denmark
    Age Ageing 41:171-7. 2012
    ..The choice of reference values for dual X-ray absorptiometry (DXA) is debated. We evaluated the prevalence of osteoporosis and vertebral deformities in a population-based sample of men...
  2. doi Self-rated health and physician-rated health as independent predictors of mortality in elderly men
    Erik J Giltay
    Department of Psychiatry, Leiden University Medical Center, P O Box 9600, 2300 RC, Leiden, The Netherlands
    Age Ageing 41:165-71. 2012
    ..When assessing health status, physicians may focus on objective symptoms and diagnoses, whereas individuals may focus more on subjective symptoms, functional limitations and quality of life...
  3. ncbi Low respiratory function increases the risk of depressive symptoms in later life in men
    Erik J Giltay
    Department of Psychiatry, Leiden University Medical Center, Leiden, 2300 RC Leiden, Netherlands
    Psychosom Med 72:53-60. 2010
    ..Chronic lung diseases are associated with a high prevalence of depression, but the association of poor respiratory function with depressive symptoms has not been established in prospective population-based cohort studies...
  4. ncbi Psychotic symptoms in patients undergoing coronary artery bypass grafting and heart valve operation
    Erik J Giltay
    GGZ Delfland, Institute of Mental Health, P O Box 5016, 2600 GA Delft, The Netherlands
    Eur J Cardiothorac Surg 30:140-7. 2006
    ..Whether psychosis, the symptom of delirium that may be recognized most promptly, is similarly associated with these factors and outcomes is largely unknown...
  5. ncbi Serum markers of brain-cell damage and C-reactive protein are unaffected by electroconvulsive therapy
    Erik J Giltay
    GGZ Delfland, Institute of Mental Health, Delft, The Netherlands
    World J Biol Psychiatry 9:231-5. 2008
    ..Serum levels of markers of brain cell leakage and inflammation remained low following one ECT session, suggesting that ECT does not cause direct brain cell leakage, nor an inflammatory response...
  6. ncbi Lifestyle and dietary correlates of dispositional optimism in men: The Zutphen Elderly Study
    Erik J Giltay
    Department of Psychiatry, Leiden University Medical Center, Leiden, The Netherlands
    J Psychosom Res 63:483-90. 2007
    ..We therefore studied whether dispositional optimism was associated with healthy lifestyle and dietary habits...
  7. ncbi Effects of sex steroids on the neurotransmitter-specific aromatic amino acids phenylalanine, tyrosine, and tryptophan in transsexual subjects
    Erik J Giltay
    Department of Psychiatry, Leiden University Medical Center, Leiden, The Netherlands
    Neuroendocrinology 88:103-10. 2008
    ..The aim of this study was to assess whether sex steroids affect plasma levels of these aromatic amino acids...
  8. ncbi Cardiovascular risk profile and subsequent disability and mental well-being: the Zutphen Elderly Study
    Erik J Giltay
    Department of Psychiatry, Leiden University Medical Center, Leiden, The Netherlands
    Am J Geriatr Psychiatry 16:874-82. 2008
    ..It is insufficiently known whether "classic" cardiovascular risk factors are associated with subsequent functional disability and mental well-being in elderly men...
  9. doi Serum cholesterol, apolipoprotein E genotype and depressive symptoms in elderly European men: the FINE study
    Erik J Giltay
    Leiden University Medical Center, Department of Psychiatry, Leiden, The Netherlands
    J Affect Disord 115:471-7. 2009
    ..Using a Mendelian randomization design, the potential association between apolipoprotein E (APOE) genotype (affecting lifetime cholesterol levels) and depressive symptoms was studied...
  10. doi C-reactive protein levels and ageing male symptoms in hypogonadal men treated with testosterone supplementation
    E J Giltay
    Department of Psychiatry, Leiden University Medical Center, Leiden, The Netherlands
    Andrologia 40:398-400. 2008
    ..22; P < 0.001), while adjusting for smoking, alcohol use, age, and body mass index. Low-grade inflammation may be involved in the pathogenesis of subjective symptoms of androgen deficiency in ageing men...
  11. ncbi Potential side effects of androgen deprivation treatment in sex offenders
    Erik J Giltay
    Department of Psychiatry, Leiden University Medical Center, Leiden, The Netherlands
    J Am Acad Psychiatry Law 37:53-8. 2009
    ..Effective and safe management of sex offenders treated with testosterone-deprivation therapy should include careful monitoring of side effects and their prevention and treatment...
  12. ncbi Effects of testosterone supplementation on depressive symptoms and sexual dysfunction in hypogonadal men with the metabolic syndrome
    Erik J Giltay
    Department of Psychiatry, Leiden University Medical Center, Leiden, The Netherlands
    J Sex Med 7:2572-82. 2010
    ..Low testosterone levels in men are associated with the metabolic syndrome (MetS) as well as with depressive symptoms, low vitality, and sexual dysfunction...
  13. doi Respiratory function and other biological risk factors for completed suicide: 40 years of follow-up of European cohorts of the Seven Countries Study
    Erik J Giltay
    Leiden University Medical Center, Department of Psychiatry, Leiden, The Netherlands
    J Affect Disord 120:249-53. 2010
    ..Prospective cohort studies on biological risk factors of completed suicide are scarce. We aimed to test which biological risk factors independently identify subjects at increased risk of suicidal death...
  14. pmc Apolipoprotein E genotype modifies the association between midlife lung function and cognitive function in old age
    Erik J Giltay
    Leiden University Medical Center, Department of Psychiatry, NL 2300 RC Leiden, The Netherlands
    Dement Geriatr Cogn Disord 28:433-41. 2009
    ....
  15. ncbi Dispositional optimism and the risk of depressive symptoms during 15 years of follow-up: the Zutphen Elderly Study
    Erik J Giltay
    GGZ Delfland, Institute of Mental Health, P O Box 5016, 2600 GA Delft, The Netherlands
    J Affect Disord 91:45-52. 2006
    ....
  16. ncbi The sex difference of plasma homovanillic acid is unaffected by cross-sex hormone administration in transsexual subjects
    Erik J Giltay
    Geestelijke Gezondheidszorg Delfland, Institute of Mental Health, PO Box 5016, 2600 GA Delft, The Netherlands
    J Endocrinol 187:109-16. 2005
    ....
  17. ncbi Effects of sex steroid deprivation/administration on hair growth and skin sebum production in transsexual males and females
    E J Giltay
    Research Institute for Endocrinology, Reproduction and Metabolism, University Hospital Vrije Universiteit, The Netherlands
    J Clin Endocrinol Metab 85:2913-21. 2000
    ..In the virtual absence of androgens, hair growth continues but at a slower rate. In women, after 12 months of androgen administration, hair diameters have not reached values of adult men...
  18. ncbi High stability of markers of cardiovascular risk in blood samples
    Erik J Giltay
    Division of Human Nutrition and Epidemiology, Wageningen University, The Netherlands
    Clin Chem 49:652-5. 2003
  19. ncbi Oral and transdermal estrogens both lower plasma total homocysteine in male-to-female transsexuals
    Erik J Giltay
    Department of Human Nutrition and Epidemiology, Wageningen University, P O Box 8129, Netherlands
    Atherosclerosis 168:139-46. 2003
    ..Thus, oral and transdermal estrogens decrease plasma tHcy to a similar degree (by geometric mean -26%), which suggests that a hepatic mechanism is unlikely to play an important role in the decline of tHcy levels...
  20. ncbi Dispositional optimism and the risk of cardiovascular death: the Zutphen Elderly Study
    Erik J Giltay
    GGZ Delfland, Institute of Mental Health, Delft
    Arch Intern Med 166:431-6. 2006
    ..We aimed to determine whether dispositional optimism is a stable trait over time and whether it is independently related to lower cardiovascular mortality in elderly men...
  21. ncbi Established risk factors for coronary heart disease are unrelated to androgen-induced baldness in female-to-male transsexuals
    E J Giltay
    Department of Endocrinology, Andrology Unit, Vrije University Medical Center, Amsterdam, The Netherlands
    J Endocrinol 180:107-12. 2004
    ..Therefore, our findings do not support the idea that MPB serves as an indicator of increased CHD risk through androgenic effects on classic CHD risk factors...
  22. ncbi Raloxifene and hormone replacement therapy increase arachidonic acid and docosahexaenoic acid levels in postmenopausal women
    Erik J Giltay
    Psychiatric Center GGZ Delfland, Delft, The Netherlands
    J Endocrinol 182:399-408. 2004
    ..Short term administration of raloxifene in elderly men did not affect AA or DHA. The synthesis of AA and DHA from precursors may be enhanced through an estrogen receptor-dependent pathway...
  23. ncbi Dispositional optimism and all-cause and cardiovascular mortality in a prospective cohort of elderly dutch men and women
    Erik J Giltay
    Psychiatric Center GGZ Delfland, Delft Division of Human Nutrition, Wageningen University, Wageningen, The Netherlands
    Arch Gen Psychiatry 61:1126-35. 2004
    ..Major depression is known to be related to higher cardiovascular mortality. However, epidemiological data regarding dispositional optimism in relation to mortality are scanty...
  24. ncbi Docosahexaenoic acid concentrations are higher in women than in men because of estrogenic effects
    Erik J Giltay
    Psychiatric Center GGZ Delfland, Delft, Netherlands
    Am J Clin Nutr 80:1167-74. 2004
    ..During pregnancy there is a high demand for docosahexaenoic acid (DHA), which is needed for formation of the fetal brain. Women who do not consume marine foods must synthesize DHA from fatty acid precursors in vegetable foods...
  25. ncbi Electroconvulsive therapy (ECT) in a patient with a dual-chamber sensing, VDDR pacemaker
    Erik J Giltay
    Psychiatric Center, GGZ Delfland, Delft, The Netherlands
    J ECT 21:35-8. 2005
    ..Because previous case reports involved old pacemaker models, it is unclear whether electroconvulsive therapy (ECT) may interfere with modern pacemaker function. Intracardiac voltages during ECT have not been measured previously...
  26. ncbi In vivo effects of sex steroids on lymphocyte responsiveness and immunoglobulin levels in humans
    E J Giltay
    Research Institute for Endocrinology, Reproduction, and Metabolism, University Hospital Vrije Universiteit, Amsterdam, The Netherlands
    J Clin Endocrinol Metab 85:1648-57. 2000
    ..These changes may be direct or indirect through the effects on other hormones...
  27. ncbi Androgens and ankylosing spondylitis: a role in the pathogenesis?
    E J Giltay
    Institute of Endocrinology, Reproduction and Metabolism, Hospital Vrije Universiteit, Amsterdam, The Netherlands
    Ann N Y Acad Sci 876:340-64; discussion 365. 1999
    ..Consequently, the role of sex steroids in the pathogenesis is still insufficiently elucidated...
  28. doi Impact of childhood life events and trauma on the course of depressive and anxiety disorders
    J G F M Hovens
    Department of Psychiatry, Leiden University Medical Center, The Netherlands
    Acta Psychiatr Scand 126:198-207. 2012
    ..Data on the impact of childhood life events and childhood trauma on the clinical course of depressive and anxiety disorders are limited...
  29. doi Pre-adult versus adult onset major depressive disorder in a naturalistic patient sample: the Leiden Routine Outcome Monitoring Study
    M S van Noorden
    Department of Psychiatry, Leiden University Medical Center, Leiden, The Netherlands
    Psychol Med 41:1407-17. 2011
    ..As data from naturalistic psychiatric specialty care settings are scarce, we examined phenotypic differences between pre-adult and adult onset MDD in a large sample of consecutive out-patients...
  30. ncbi n-3 fatty acids and cardiovascular events after myocardial infarction
    Daan Kromhout
    Division of Human Nutrition, Wageningen University, Wageningen, The Netherlands
    N Engl J Med 363:2015-26. 2010
    ....
  31. ncbi Predictors of outcome in outpatients with anxiety disorders: the Leiden routine outcome monitoring study
    A Schat
    Leiden University Medical Centre, Department of Psychiatry, P O Box 7500, 2300 RC Leiden, The Netherlands Electronic address
    J Psychiatr Res 47:1876-85. 2013
    ..A comprehensive ROM screening process at intake may aid clinicians in the identification of patients at risk of chronicity...
  32. pmc No effects of n-3 fatty acid supplementation on serum total testosterone levels in older men: the Alpha Omega Trial
    E J Giltay
    Department of Psychiatry, Leiden University Medical Center, Leiden, The Netherlands
    Int J Androl 35:680-7. 2012
    ..0 nmol/L). We conclude that n-3 fatty acids supplementation did not affect serum total testosterone in men who had had a MI...
  33. doi Psychiatric disorders in Huntington's disease: a 2-year follow-up study
    W Reedeker
    Department of Psychiatry, Leiden University Medical Center, The Netherlands
    Psychosomatics 53:220-9. 2012
    ....
  34. doi Metabolic syndrome abnormalities are associated with severity of anxiety and depression and with tricyclic antidepressant use
    A K B van Reedt Dortland
    Department of Psychiatry, Leiden University Medical Centre, The Netherlands
    Acta Psychiatr Scand 122:30-9. 2010
    ..There might also be an association between the MetSyn and anxiety and depression, but its nature is unclear. We aimed to investigate whether diagnosis, symptom severity and antidepressant use are associated with the MetSyn...
  35. doi Suicidality in Huntington's disease
    A A M Hubers
    Department of Psychiatry, Leiden University Medical Center, Leiden, The Netherlands
    J Affect Disord 136:550-7. 2012
    ..In Huntington's disease (HD) the risk of suicide is increased. Since suicidality may precede suicide, this study investigates prevalence, clinical associations and predictors of suicidality in HD...
  36. ncbi Differential effects of cross-sex hormonal treatment on plasma asymmetric dimethylarginine (ADMA) in healthy male-to-female and female-to-male transsexuals
    Mathijs C Bunck
    Department of Endocrinology, VU University Medical Center, Amsterdam, The Netherlands
    Atherosclerosis 206:245-50. 2009
    ..We investigated the effects of cross-sex hormone treatment (CHT) on plasma ADMA concentration in an open-label study in 40 male-to-female (M-F) and 14 female-to-male (F-M) transsexuals...
  37. pmc A common and functional mineralocorticoid receptor haplotype enhances optimism and protects against depression in females
    M D Klok
    Division of Medical Pharmacology, Leiden Amsterdam Center for Drug Research, Leiden University Medical Center, Leiden, The Netherlands
    Transl Psychiatry 1:e62. 2011
    ..We propose that common functional MR haplotypes are important determinants of inter-individual variability in resilience to depression in women by differentially mediating cortisol effects on the stress system...
  38. doi Predictive value of geriatric assessment for patients older than 70 years, treated with chemotherapy
    A A Aaldriks
    Institute of Mental Health, GGZ Delfland, Delft, The Netherlands
    Crit Rev Oncol Hematol 79:205-12. 2011
    ..However, its meaning for a proper selection of elderly patients before chemotherapy and, even more important, the influence of chemotherapy on the outcome of geriatric assessment is unknown...
  39. ncbi Effect of low doses of n-3 fatty acids on cardiovascular diseases in 4,837 post-myocardial infarction patients: design and baseline characteristics of the Alpha Omega Trial
    Johanna M Geleijnse
    Division of Human Nutrition, Wageningen University, Wageningen, The Netherlands
    Am Heart J 159:539-546.e2. 2010
    ..There is a need for food-based trials to establish the efficacy of low doses of n-3 fatty acids in CVD prevention...
  40. ncbi Gonadal and adrenal sex steroids in ankylosing spondylitis
    L J Gooren
    Department of Endocrinology, University Hospital Vrije Universiteit, Amsterdam, The Netherlands
    Rheum Dis Clin North Am 26:969-87. 2000
    ..Alternative explanations for the higher male prevalence of AS may be found in the different chromosomal configuration and body composition of men and women...
  41. doi Risk of depressive symptoms in the oldest old subjects with chronic obstructive pulmonary disease: the Leiden 85-plus study
    Nathaly Rius Ottenheim
    Department of Psychiatry, Leiden University Medical Center, Leiden, The Netherlands
    Am J Geriatr Psychiatry 18:388-94. 2010
    ..The authors aimed to determine whether oldest old persons with COPD are at increased risk of developing depressive symptoms...
  42. ncbi Long-term treatment of transsexuals with cross-sex hormones: extensive personal experience
    Louis J Gooren
    Department of Endocrinology, Vrije Universiteit University Medical Center, De Boelelaan 1118, 1081 HV Amsterdam, The Netherlands
    J Clin Endocrinol Metab 93:19-25. 2008
    ..Transsexuals receive cross-sex hormone treatment. Its short-term use appears reasonably safe. Little is known about its long-term use. This report offers some perspectives...
  43. ncbi The importance of childhood trauma and childhood life events for chronicity of depression in adults
    Jenneke E Wiersma
    Department of Psychiatry and Institute for Research in Extramural Medicine, VU University Medical Center and Academic Outpatient Clinic for Affective Disorders, GGZ inGeest, Amsterdam, The Netherlands
    J Clin Psychiatry 70:983-9. 2009
    ....
  44. doi Childhood life events and childhood trauma in adult patients with depressive, anxiety and comorbid disorders vs. controls
    J G F M Hovens
    Leiden University Medical Center, Department of Psychiatry, The Netherlands
    Acta Psychiatr Scand 122:66-74. 2010
    ..To investigate the association between childhood life events, childhood trauma and the presence of anxiety, depressive or comorbid anxiety and depressive disorders in adulthood...
  45. ncbi 4G/4G genotype of PAI-1 gene is associated with reduced risk of stroke in elderly
    Tiny Hoekstra
    Division of Human Nutrition, Wageningen University, Netherlands
    Stroke 34:2822-8. 2003
    ..We investigated whether plasma PAI-1 and 4G/5G genotype would predict the occurrence of cardiovascular events at old age...
  46. ncbi Acute-phase proteins in relation to neuropsychiatric symptoms and use of psychotropic medication in Huntington׳s disease
    J A Bouwens
    Department of Psychiatry, Leiden University Medical Center, The Netherlands Electronic address
    Eur Neuropsychopharmacol 24:1248-56. 2014
    ..This study provides evidence that HD mutation carriers who use antipsychotics are prone to develop an acute-phase response. ..
  47. doi Phenomenology of depression in older compared with younger adults: meta-analysis
    J M Hegeman
    Department of Psychiatry, Leiden University Medical Centre, Albinusdreef 2, 2333 ZA Leiden, The Netherlands
    Br J Psychiatry 200:275-81. 2012
    ..Late-life depression may differ from early-life depression in its phenomenology...
  48. doi Correlates of apathy in Huntington's disease
    E van Duijn
    Leiden University Medical Center, Department of Psychiatry, B1 P, PO Box 9600, 2300 RC Leiden, The Netherlands
    J Neuropsychiatry Clin Neurosci 22:287-94. 2010
    ..After exclusion of 10 depressed patients, apathy was independently associated with male sex, worse global functioning, and higher use of neuroleptics and benzodiazepines...
  49. doi Gender differences in clinical characteristics in a naturalistic sample of depressive outpatients: the Leiden Routine Outcome Monitoring Study
    Martijn S van Noorden
    Department of Psychiatry, Leiden University Medical Center, Leiden, The Netherlands
    J Affect Disord 125:116-23. 2010
    ..We therefore determined gender differences in comorbidity, symptom patterns and subjective health status in these outpatients in a mental healthcare setting...
  50. ncbi Effects of sex steroids on components of the insulin resistance syndrome in transsexual subjects
    Jolanda M H Elbers
    Department of Endocrinology, Andrology Unit, Wageningen University, The Netherlands
    Clin Endocrinol (Oxf) 58:562-71. 2003
    ..These differences are attributed to sex-specific sex steroid profiles, but the effects of sex steroids on the individual components of the insulin resistance syndrome remain incompletely understood...
  51. ncbi Association of n-3 long-chain PUFA and fish intake with depressive symptoms and low dispositional optimism in older subjects with a history of myocardial infarction
    Ondine van de Rest
    Division of Human Nutrition, Wageningen University, 6700 EV Wageningen, The Netherlands
    Br J Nutr 103:1381-7. 2010
    ..In conclusion, intake of EPA+DHA was positively associated with dispositional optimism assessed with the 4Q, but not with optimism assessed with the LOT-R or with depressive symptoms...
  52. doi Associations between serum lipids and major depressive disorder: results from the Netherlands Study of Depression and Anxiety (NESDA)
    Arianne K B van Reedt Dortland
    Leiden University Medical Centre, Department of Psychiatry, PO Box 9600, 2300 RC Leiden, The Netherlands
    J Clin Psychiatry 71:729-36. 2010
    ..However, previous studies did not always take into consideration potentially mediating factors or heterogeneity of symptoms, which may clarify contradicting findings...
  53. ncbi Serum and urine tissue kallikrein concentrations in male-to-female transsexuals treated with antiandrogens and estrogens
    Margrita H Slagter
    Department of Endocrinology, VU University Medical Centre, Amsterdam, The Netherlands
    Clin Chem 52:1356-65. 2006
    ..Our purpose was to examine serum and urinary tissue kallikrein concentration changes in male-to-female transsexuals before and after treatment with antiandrogens and estrogens...
  54. doi The influence of psychiatric comorbidity on the dexamethasone/CRH test in major depression
    Gerthe Veen
    Department of Psychiatry, Leiden University Medical Center, PO Box 9600, 2300 RC Leiden, The Netherlands
    Eur Neuropsychopharmacol 19:409-15. 2009
    ..The present study investigated whether comorbidity of anxiety or somatoform disorders might be an explaining factor for this finding...
  55. doi Routine outcome monitoring in the Netherlands: practical experiences with a web-based strategy for the assessment of treatment outcome in clinical practice
    E de Beurs
    Department of Psychiatry, Leiden University Medical Centre, The Netherlands
    Clin Psychol Psychother 18:1-12. 2011
    ..In addition, ROM furthers research as the data can be used to study the phenomenology of psychiatric disorders and the outcome of treatments delivered in everyday practice...
  56. ncbi Review of studies of androgen treatment of female-to-male transsexuals: effects and risks of administration of androgens to females
    Louis J G Gooren
    Department of Endocrinology, Andrology Unit, VU University Medical Center, Amsterdam, The Netherlands
    J Sex Med 5:765-76. 2008
    ..Naturally, androgens may have virilizing effects in women. It is often believed that androgens have deleterious effects on cardiovascular risks...
  57. doi The structure and dimensionality of the Inventory of Depressive Symptomatology Self Report (IDS-SR) in patients with depressive disorders and healthy controls
    Klaas J Wardenaar
    Department of Psychiatry, Leiden University Medical Center, Leiden, The Netherlands
    J Affect Disord 125:146-54. 2010
    ..However previous factoranalytical studies have found mixed results. Therefore, the present study tested which factor structure underlies the IDS-SR and, in addition, if the factors can be used as unidimensional subscales...
  58. ncbi Measurement of psychopathology in Huntington's disease: the critical role of caregivers
    Erik van Duijn
    Center for Mental Health Care Delfland, Delft, The Netherlands
    J Nerv Ment Dis 198:329-33. 2010
    ....
  59. ncbi Men and women, so different, so similar: observations from cross-sex hormone treatment of transsexual subjects
    L J Gooren
    Emeritus VU University Medical Center, Amsterdam, The Netherlands
    Andrologia 46:570-5. 2014
    ..The insights gained with these studies should lead to a better appreciation of the role of sex steroids in cardiovascular disease and diabetes mellitus which presently do not receive due attention. ..
  60. doi The relationship between disease activity and depressive symptoms severity and optimism--results from the IMPROVED study
    L Heimans
    Department of Rheumatology, Leiden University Medical Center, PO Box 9600, 2300 RC, Leiden, The Netherlands
    Clin Rheumatol 32:1751-7. 2013
    ..Depression scores are associated with pain and unwell being but not with swollen joint counts and inflammatory parameters...
  61. ncbi Effect of testosterone administration on serum and urine kallikrein concentrations in female-to-male transsexuals
    Margrita H Slagter
    Department of Endocrinology, Vrije Universiteit University Medical Centre, Amsterdam, The Netherlands, and Department of Pathology and Laboratory Medicine, Mount Sinai Hospital, Toronto, ON, Canada
    Clin Chem 52:1546-51. 2006
    ..To gain insight into in vivo kallikrein regulation we measured kallikrein concentrations in serum and urinary tissue in female-to-male transsexuals before and after testosterone administration...
  62. doi Salivary cortisol, serum lipids, and adiposity in patients with depressive and anxiety disorders
    Gerthe Veen
    Department of Psychiatry, Leiden University Medical Center, PO Box 9600, 2300 RC Leiden, The Netherlands
    Metabolism 58:821-7. 2009
    ..These data lend support to the hypothesis that the relationship between affective disorders and cardiovascular disease is partly mediated by HPA-axis perturbations...
  63. doi Development and validation of a 30-item short adaptation of the Mood and Anxiety Symptoms Questionnaire (MASQ)
    Klaas J Wardenaar
    Department of Psychiatry, Leiden University Medical Centre, Leiden, The Netherlands
    Psychiatry Res 179:101-6. 2010
    ..In conclusion, the MASQ-D30 is a valid instrument to assess dimensional aspects of depression and anxiety and can easily be implemented in psychopathology studies...
  64. doi Telomere length and mortality in elderly men: the Zutphen Elderly Study
    Joyce M J Houben
    Department of Health Risk Analysis and Toxicology, NUTRIM School for Nutrition, Toxicology and Metabolism, Maastricht University Medical Centre, The Netherlands
    J Gerontol A Biol Sci Med Sci 66:38-44. 2011
    ..These results suggest that LTL decreases with increasing age and that LTL is not related to mortality in men aged more than 70 years...
  65. doi Hypokinesia in Huntington's disease co-occurs with cognitive and global dysfunctioning
    Nanda Reedeker
    Department of Psychiatry, Leiden University Medical Center, Leiden, The Netherlands
    Mov Disord 25:1612-8. 2010
    ..In conclusion, the presence of moderate to severe hypokinesia in HD patients co-occurs with executive cognitive dysfunction and adversely affects global functioning...
  66. ncbi Effects of childhood trauma on HPA-axis reactivity in women free of lifetime psychopathology
    Ellen R Klaassens
    Department of Psychiatry, Leiden University Medical Center LUMC, Albinusdreef 2, 2333 ZA Leiden, The Netherlands
    Prog Neuropsychopharmacol Biol Psychiatry 33:889-94. 2009
    ..Although basal cortisol patterns were similar in the two groups, exposure to childhood trauma seemed to be related to a blunted HPA-axis reactivity in women who were free of current or lifetime psychopathology...
  67. ncbi Blood pressure response to fish oil supplementation: metaregression analysis of randomized trials
    Johanna M Geleijnse
    Division of Human Nutrition and Epidemiology, Wageningen University, The Netherlands
    J Hypertens 20:1493-9. 2002
    ..The antihypertensive effect of fish oil was estimated from randomized trials using metaregression analysis. Modification of the blood pressure (BP) effect by age, gender, blood pressure, and body mass index was examined...
  68. doi Trauma exposure and hypothalamic-pituitary- adrenal axis functioning in mentally healthy Dutch peacekeeping veterans, 10-25 years after deployment
    Ellen R Klaassens
    Department of Psychiatry, Leiden University Medical Center LUMC, Leiden, The Netherlands
    J Trauma Stress 23:124-31. 2010
    ..The authors concluded that this study does not support the idea that HPA-axis functioning is durably altered by trauma exposure during adulthood in men...