Rachel H Giles

Summary

Affiliation: University Medical Center Utrecht
Country: The Netherlands

Publications

  1. ncbi Tumor suppressors APC and VHL: gatekeepers of the intestine and kidney
    Rachel H Giles
    Department Medical Oncology, University Medical Center Utrecht, Utrecht, The Netherlands
    Prog Mol Subcell Biol 40:151-81. 2005
  2. ncbi Allele-specific regulation of primary cilia function by the von Hippel-Lindau tumor suppressor
    Martijn P Lolkema
    Department of Medical Oncology, University Medical Center Utrecht, Heidelberglaan 100, Utrecht, The Netherlands
    Eur J Hum Genet 16:73-8. 2008
  3. ncbi Caught up in a Wnt storm: Wnt signaling in cancer
    Rachel H Giles
    Hubrecht Laboratory, Netherlands Institute for Developmental Biology, Uppsalalaan 8, 3584 CT, Utrecht, The Netherlands
    Biochim Biophys Acta 1653:1-24. 2003
  4. doi von Hippel-Lindau tumor suppressor mutants faithfully model pathological hypoxia-driven angiogenesis and vascular retinopathies in zebrafish
    Ellen van Rooijen
    Hubrecht Institute, Royal Netherlands Academy of Arts and Sciences and University Medical Center Utrecht, Utrecht, The Netherlands
    Dis Model Mech 3:343-53. 2010
  5. ncbi The von Hippel-Lindau tumour suppressor interacts with microtubules through kinesin-2
    Martijn P Lolkema
    Department of Medical Oncology, University Medical Center Utrecht, Heidelberglaan 100, rm F02 126, 3584 CX Utrecht, The Netherlands
    FEBS Lett 581:4571-6. 2007
  6. ncbi Tumor suppression by the von Hippel-Lindau protein requires phosphorylation of the acidic domain
    Martijn P Lolkema
    Department of Medical Oncology, University Medical Center Utrecht, Heidelberglaan 100, 3584 CX Utrecht, The Netherlands
    J Biol Chem 280:22205-11. 2005
  7. doi Genetic analysis of von Hippel-Lindau disease
    Morgan Nordstrom-O'Brien
    Department of Medical Oncology, University Medical Center Utrecht, Universiteitsweg 100, Utrecht, The Netherlands
    Hum Mutat 31:521-37. 2010
  8. doi Zebrafish mutants in the von Hippel-Lindau tumor suppressor display a hypoxic response and recapitulate key aspects of Chuvash polycythemia
    Ellen van Rooijen
    Department of Medical Oncology, University Medical Center, Utrecht, The Netherlands
    Blood 113:6449-60. 2009
  9. ncbi Circulating mitochondrial nucleic acids have prognostic value for survival in patients with advanced prostate cancer
    Niven Mehra
    Department of Medical Oncology, University Medical Center Utrecht, 3508 GA Utrecht, The Netherlands
    Clin Cancer Res 13:421-6. 2007
  10. doi Mobility of the von Hippel-Lindau tumour suppressor protein is regulated by kinesin-2
    Dorus A Mans
    Laboratory of Experimental Oncology, Department of Medical Oncology, University Medical Center Utrecht, Utrecht, The Netherlands
    Exp Cell Res 314:1229-36. 2008

Collaborators

  • Emile E Voest
  • Rene F Ketting
  • Rene H Medema
  • Paul J van Diest
  • Nicholas Katsanis
  • Rob B van der Luijt
  • Frank C P Holstege
  • Branko Braam
  • Laurien H Ulfman
  • Richard P Hill
  • Michael Ohh
  • Hans Clevers
  • Martijn P Lolkema
  • Ellen van Rooijen
  • Sander G Basten
  • Dorus A Mans
  • Stefan Schulte-Merker
  • Niven Mehra
  • Moniek van Beest
  • Ive Logister
  • Freek J van Eeden
  • Jeanine M Roodhart
  • Morgan Nordstrom-O'Brien
  • Fredericus J van Eeden
  • Jeroen Korving
  • Astrid E Greijer
  • Nancy van Daal
  • Maarten Penning
  • Jolanda Maas
  • Cristel M Snijckers
  • Hans A R Bluyssen
  • Ad J M Gillis
  • Leendert H J Looijenga
  • Hans Stoop
  • Zachary G Heath
  • Sven Willekers
  • Nikolina Babala
  • Joost Sp Vermaat
  • Trudy N Jonges
  • Erica E Davis
  • Gisela Gg Slaats
  • Ans M van den Ouweland
  • Arnold Baars
  • Aram van Brussel
  • Joost S Vermaat
  • Danielle F Majoor-Krakauer
  • Marlies H Langenberg
  • Els O Witteveen
  • Jeroen Bussmann
  • Thorsten Schwerte
  • Victor W M van Hinsbergh
  • Pien M Delis-van Diemen
  • Gerrit A Meijer
  • Carina van Rooijen
  • Laura G Daenen
  • Remond J A Fijneman
  • Stefano Volpi
  • Mascha van Noort
  • Carla H van Gils
  • Laurens V Beerepoot
  • Michelle L Gervais
  • Maartje Los
  • Anita S Jorna
  • Martijn F B G Gebbink
  • Martijn P J K Lolkema
  • Michelle Boone
  • Cristel M J T Snijckers

Detail Information

Publications20

  1. ncbi Tumor suppressors APC and VHL: gatekeepers of the intestine and kidney
    Rachel H Giles
    Department Medical Oncology, University Medical Center Utrecht, Utrecht, The Netherlands
    Prog Mol Subcell Biol 40:151-81. 2005
  2. ncbi Allele-specific regulation of primary cilia function by the von Hippel-Lindau tumor suppressor
    Martijn P Lolkema
    Department of Medical Oncology, University Medical Center Utrecht, Heidelberglaan 100, Utrecht, The Netherlands
    Eur J Hum Genet 16:73-8. 2008
    ..Furthermore, reduction of cellular levels of VHL in this cell system was associated with fewer ciliated cells, suggesting a role for VHL in ciliary maintenance...
  3. ncbi Caught up in a Wnt storm: Wnt signaling in cancer
    Rachel H Giles
    Hubrecht Laboratory, Netherlands Institute for Developmental Biology, Uppsalalaan 8, 3584 CT, Utrecht, The Netherlands
    Biochim Biophys Acta 1653:1-24. 2003
    ....
  4. doi von Hippel-Lindau tumor suppressor mutants faithfully model pathological hypoxia-driven angiogenesis and vascular retinopathies in zebrafish
    Ellen van Rooijen
    Hubrecht Institute, Royal Netherlands Academy of Arts and Sciences and University Medical Center Utrecht, Utrecht, The Netherlands
    Dis Model Mech 3:343-53. 2010
    ..Importantly, they will allow for a cost-effective, non-invasive and efficient way to screen for novel pharmacological agents and combinatorial treatments...
  5. ncbi The von Hippel-Lindau tumour suppressor interacts with microtubules through kinesin-2
    Martijn P Lolkema
    Department of Medical Oncology, University Medical Center Utrecht, Heidelberglaan 100, rm F02 126, 3584 CX Utrecht, The Netherlands
    FEBS Lett 581:4571-6. 2007
    ..The interaction with kinesin-2 facilitates pVHL binding to microtubules. These data suggest that microtubule-dependent functions of pVHL are influenced by kinesin-2...
  6. ncbi Tumor suppression by the von Hippel-Lindau protein requires phosphorylation of the acidic domain
    Martijn P Lolkema
    Department of Medical Oncology, University Medical Center Utrecht, Heidelberglaan 100, 3584 CX Utrecht, The Netherlands
    J Biol Chem 280:22205-11. 2005
    ..We propose that phosphorylation of the acidic domain plays a role in the regulation of proper fibronectin matrix deposition and that this may be relevant for the development of VHL-associated malignancies...
  7. doi Genetic analysis of von Hippel-Lindau disease
    Morgan Nordstrom-O'Brien
    Department of Medical Oncology, University Medical Center Utrecht, Universiteitsweg 100, Utrecht, The Netherlands
    Hum Mutat 31:521-37. 2010
    ..This easy-to-use compilation of VHL mutations is intended to facilitate research and function as a necessary adjunct for physicians when providing patient information...
  8. doi Zebrafish mutants in the von Hippel-Lindau tumor suppressor display a hypoxic response and recapitulate key aspects of Chuvash polycythemia
    Ellen van Rooijen
    Department of Medical Oncology, University Medical Center, Utrecht, The Netherlands
    Blood 113:6449-60. 2009
    ..They will contribute to our understanding of hypoxic signaling, hematopoiesis, and VHL-associated disease progression...
  9. ncbi Circulating mitochondrial nucleic acids have prognostic value for survival in patients with advanced prostate cancer
    Niven Mehra
    Department of Medical Oncology, University Medical Center Utrecht, 3508 GA Utrecht, The Netherlands
    Clin Cancer Res 13:421-6. 2007
    ..We assessed whether we could distinguish poor from good prognosis patients at presentation in our clinic by means of quantifying circulating cell-free mitochondrial and genomic nucleic acids in plasma...
  10. doi Mobility of the von Hippel-Lindau tumour suppressor protein is regulated by kinesin-2
    Dorus A Mans
    Laboratory of Experimental Oncology, Department of Medical Oncology, University Medical Center Utrecht, Utrecht, The Netherlands
    Exp Cell Res 314:1229-36. 2008
    ..From these data we suggest that mobility of a subcellular pool of pVHL is regulated by the ATP-dependent kinesin-2 motor. Kinesin-2 driven mobility of cytoplasmic pVHL might enable pVHL to function as a tumour suppressor...
  11. doi All along the watchtower: is the cilium a tumor suppressor organelle?
    Dorus A Mans
    Department of Medical Oncology, University Medical Center Utrecht, The Netherlands
    Biochim Biophys Acta 1786:114-25. 2008
    ..Furthermore, we predict that we are just now seeing the tip of the iceberg, and that the list of cancers associated with altered ciliary signalling will grow exponentially in the next few years...
  12. ncbi The von Hippel-Lindau tumor suppressor protein influences microtubule dynamics at the cell periphery
    Martijn P Lolkema
    Department of Medical Oncology, University Medical Center Utrecht, Utrecht, The Netherlands
    Exp Cell Res 301:139-46. 2004
    ..Here we propose a complementary method to directly measure VHL-induced subcellular changes in microtubule dynamics, which may serve as a tool to study the effect of MT binding proteins such as VHL...
  13. pmc Late release of circulating endothelial cells and endothelial progenitor cells after chemotherapy predicts response and survival in cancer patients
    Jeanine M Roodhart
    Department of Medical Oncology, University Medical Center Utrecht, Utrecht, The Netherlands
    Neoplasia 12:87-94. 2010
    ..The correlation with a clinical response and survival provides further support for the biologic relevance of these cells in patients' prognosis and stresses their possible use as a therapeutic target...
  14. pmc Mutations in LRRC50 Predispose Zebrafish and Humans to Seminomas
    Sander G Basten
    Department of Medical Oncology, University Medical Center Utrecht, Utrecht, The Netherlands
    PLoS Genet 9:e1003384. 2013
    ..Together, our study introduces an animal model for seminoma and suggests LRRC50 to be a novel tumor suppressor implicated in human seminoma pathogenesis...
  15. ncbi Progenitor marker CD133 mRNA is elevated in peripheral blood of cancer patients with bone metastases
    Niven Mehra
    Department of Medical Oncology and Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, The Netherlands
    Clin Cancer Res 12:4859-66. 2006
    ....
  16. pmc LRRC50, a conserved ciliary protein implicated in polycystic kidney disease
    Ellen van Rooijen
    Hubrecht Institute, Developmental Biology and Stem Cell Research, University Medical Center Utrecht, Utrecht, Netherlands
    J Am Soc Nephrol 19:1128-38. 2008
    ....
  17. pmc Reduced cilia frequencies in human renal cell carcinomas versus neighboring parenchymal tissue
    Sander G Basten
    Department of Nephrology and Hypertension, University Medical Center Utrecht, Heidelberglaan 100, 3584, CX, Utrecht, The Netherlands
    Cilia 2:2. 2013
    ..abstract:..
  18. pmc Functional aspects of primary cilia in signaling, cell cycle and tumorigenesis
    Sander G Basten
    Department of Nephrology and Hypertension, University Medical Center Utrecht, Heidelberglaan 100, Utrecht, F03, 223, 3584 CX, The Netherlands
    Cilia 2:6. 2013
    ....
  19. ncbi Fibronectin is a hypoxia-independent target of the tumor suppressor VHL
    Hans A R Bluyssen
    Department of Medical Oncology, University Medical Center Utrecht, P O Box 85500, 3500 GA, Utrecht, The Netherlands
    FEBS Lett 556:137-42. 2004
    ..Thus regulation of fibronectin deposition by VHL occurs at the transcriptional level, irrespective of oxygen levels...
  20. pmc Presence of HIF-1 and related genes in normal mucosa, adenomas and carcinomas of the colorectum
    Astrid E Greijer
    Department of Pathology, VU University Medical Centre, PO Box 7057, 1007 MB Amsterdam, The Netherlands
    Virchows Arch 452:535-44. 2008
    ....