Mirjam I Geerlings

Summary

Affiliation: University Medical Center Utrecht
Country: The Netherlands

Publications

  1. pmc Recent life events pose greatest risk for onset of major depressive disorder during mid-life
    Bauke T Stegenga
    Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, The Netherlands
    J Affect Disord 136:505-13. 2012
  2. pmc The natural course and outcome of major depressive disorder in primary care: the PREDICT-NL study
    Bauke T Stegenga
    Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Stratenum 6 131, P O Box 85500, 3508 GA Utrecht, The Netherlands
    Soc Psychiatry Psychiatr Epidemiol 47:87-95. 2012
  3. pmc Differential impact of risk factors for women and men on the risk of major depressive disorder
    Bauke T Stegenga
    Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, The Netherlands
    Ann Epidemiol 22:388-96. 2012
  4. pmc Progression of White Matter Lesion Volume and Health-Related Quality of Life in Patients with Symptomatic Atherosclerotic Disease: The SMART-MR Study
    Anne M Grool
    Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Stratenum 6 131, P O Box 85500, 3508 GA Utrecht, The Netherlands
    J Aging Res 2011:280630. 2011
  5. pmc Association between subcortical vascular lesion location and cognition: a voxel-based and tract-based lesion-symptom mapping study. The SMART-MR study
    J Matthijs Biesbroek
    Department of Neurology, Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, Utrecht, The Netherlands
    PLoS ONE 8:e60541. 2013
  6. doi request reprint Associations of current and remitted major depressive disorder with brain atrophy: the AGES-Reykjavik Study
    M I Geerlings
    University Medical Center Utrecht, Julius Center for Health Sciences and Primary Care, The Netherlands
    Psychol Med 43:317-28. 2013
  7. pmc Depressive symptoms, antidepressant use, and brain volumes on MRI in a population-based cohort of old persons without dementia
    Mirjam I Geerlings
    University Medical Center Utrecht, Julius Center for Health Sciences and Primary Care, Utrecht, The Netherlands
    J Alzheimers Dis 30:75-82. 2012
  8. pmc Prediction of depression in European general practice attendees: the PREDICT study
    Michael King
    Department of Mental Health Sciences, UCL, London, UK
    BMC Public Health 6:6. 2006
  9. doi request reprint Brain volumes and cerebrovascular lesions on MRI in patients with atherosclerotic disease. The SMART-MR study
    Mirjam I Geerlings
    Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, 3508 GA Utrecht, The Netherlands
    Atherosclerosis 210:130-6. 2010
  10. ncbi request reprint Endogenous sex hormones, cognitive decline, and future dementia in old men
    Mirjam I Geerlings
    University Medical Center Utrecht, Julius Center for Health Sciences and Primary Care, Utrecht, The Netherlands
    Ann Neurol 60:346-55. 2006

Detail Information

Publications72

  1. pmc Recent life events pose greatest risk for onset of major depressive disorder during mid-life
    Bauke T Stegenga
    Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, The Netherlands
    J Affect Disord 136:505-13. 2012
    ..The authors examined an additive model for the association of life events and age with onset of major depressive disorder (MDD) and whether the combination of life events and age posed greater risk than the sum of their independent effects...
  2. pmc The natural course and outcome of major depressive disorder in primary care: the PREDICT-NL study
    Bauke T Stegenga
    Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Stratenum 6 131, P O Box 85500, 3508 GA Utrecht, The Netherlands
    Soc Psychiatry Psychiatr Epidemiol 47:87-95. 2012
    ..To examine the natural course and outcome of major depressive disorder (MDD) in primary care over 39 months...
  3. pmc Differential impact of risk factors for women and men on the risk of major depressive disorder
    Bauke T Stegenga
    Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, The Netherlands
    Ann Epidemiol 22:388-96. 2012
    ..Our aim is to examine which risk factors have a greater impact in women than in men on the risk of major depressive disorder (MDD) and whether factors differ between a possible recurrent MDD and a first onset of MDD...
  4. pmc Progression of White Matter Lesion Volume and Health-Related Quality of Life in Patients with Symptomatic Atherosclerotic Disease: The SMART-MR Study
    Anne M Grool
    Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Stratenum 6 131, P O Box 85500, 3508 GA Utrecht, The Netherlands
    J Aging Res 2011:280630. 2011
    ..76, 95% CI -3.11 to -0.42), but did not influence changes in physical functioning. Conclusions. Progression of WML volume contributes to a decline in mental functioning in patients with symptomatic atherosclerotic disease...
  5. pmc Association between subcortical vascular lesion location and cognition: a voxel-based and tract-based lesion-symptom mapping study. The SMART-MR study
    J Matthijs Biesbroek
    Department of Neurology, Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, Utrecht, The Netherlands
    PLoS ONE 8:e60541. 2013
    ..Lacunar lesions (LLs) and white matter lesions (WMLs) affect cognition. We assessed whether lesions located in specific white matter tracts were associated with cognitive performance taking into account total lesion burden...
  6. doi request reprint Associations of current and remitted major depressive disorder with brain atrophy: the AGES-Reykjavik Study
    M I Geerlings
    University Medical Center Utrecht, Julius Center for Health Sciences and Primary Care, The Netherlands
    Psychol Med 43:317-28. 2013
    ..To examine whether lifetime DSM-IV diagnosis of major depressive disorder (MDD), including age at onset and number of episodes, is associated with brain atrophy in older persons without dementia...
  7. pmc Depressive symptoms, antidepressant use, and brain volumes on MRI in a population-based cohort of old persons without dementia
    Mirjam I Geerlings
    University Medical Center Utrecht, Julius Center for Health Sciences and Primary Care, Utrecht, The Netherlands
    J Alzheimers Dis 30:75-82. 2012
    ....
  8. pmc Prediction of depression in European general practice attendees: the PREDICT study
    Michael King
    Department of Mental Health Sciences, UCL, London, UK
    BMC Public Health 6:6. 2006
    ..However, we lack reliable and valid methods of risk estimation. This protocol paper introduces PREDICT, an international research study to address this risk estimation...
  9. doi request reprint Brain volumes and cerebrovascular lesions on MRI in patients with atherosclerotic disease. The SMART-MR study
    Mirjam I Geerlings
    Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, 3508 GA Utrecht, The Netherlands
    Atherosclerosis 210:130-6. 2010
    ..To estimate brain volumes, white matter lesion (WML) volume and asymptomatic infarcts on MRI in a large cohort of patients with atherosclerotic disease...
  10. ncbi request reprint Endogenous sex hormones, cognitive decline, and future dementia in old men
    Mirjam I Geerlings
    University Medical Center Utrecht, Julius Center for Health Sciences and Primary Care, Utrecht, The Netherlands
    Ann Neurol 60:346-55. 2006
    ..To estimate the association of endogenous levels of bioavailable testosterone and estradiol with risk for cognitive decline and dementia in old men...
  11. doi request reprint White matter lesions and lacunar infarcts are independently and differently associated with brain atrophy: the SMART-MR study
    Auke P A Appelman
    Department of Radiology, University Medical Center Utrecht, Utrecht, The Netherlands
    Cerebrovasc Dis 29:28-35. 2010
    ..To investigate the independent association of white matter lesions (WML) and lacunar infarcts (LI) with measures of global brain atrophy on MRI...
  12. ncbi request reprint No increased incidence of diabetes in antidepressant users
    Mirjam J Knol
    Julius Center for Health Sciences and Primary Care, Utrecht, The Netherlands
    Int Clin Psychopharmacol 22:382-6. 2007
    ..12-1.68) for AD and BD users compared with no AD and no BD users. We did not find an increased risk of diabetes in individuals using ADs. The association between BD use and diabetes was partly explained by chronic somatic comorbidity...
  13. doi request reprint Location of cerebrovascular and degenerative changes, depressive symptoms and cognitive functioning in later life: the SMART-Medea study
    Anne M Grool
    Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, The Netherlands
    J Neurol Neurosurg Psychiatry 82:1093-100. 2011
    ..Structural changes in critical brain regions may underlie both conditions. The authors examined associations of infarcts, white-matter lesions (WML) and atrophy at different locations with depressive symptoms and cognitive functioning...
  14. doi request reprint Homocysteine, progression of ventricular enlargement, and cognitive decline: the Second Manifestations of ARTerial disease-Magnetic Resonance study
    Hadassa M Jochemsen
    Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, The Netherlands
    Alzheimers Dement 9:302-9. 2013
    ..We examined whether homocysteine increased the risk for cognitive decline and brain atrophy, and evaluated the modifying effect of age...
  15. doi request reprint The association of depression with cardiovascular mortality is partly explained by health status. The FINE Study
    Marjolein H Kamphuis
    Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, The Netherlands
    J Affect Disord 114:184-92. 2009
    ..We investigated to what extent subjective health status explained the apparent association between depressive symptoms and cardiovascular mortality in older European men...
  16. ncbi request reprint Basal hypothalamic pituitary adrenal axis activity and hippocampal volumes: the SMART-Medea study
    Arnoud J G Knoops
    Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, The Netherlands
    Biol Psychiatry 67:1191-8. 2010
    ....
  17. doi request reprint Homocysteine and progression of generalized small-vessel disease: the SMART-MR Study
    Raoul P Kloppenborg
    From the Department of Neurology R P K, M V, P J N, Academic Medical Center, Amsterdam and Departments of Neurology R P K, Internal Medicine F L V, and Radiology W P T M M, and Julius Center for Health Sciences and Primary Care R P K, M I G, Y v d G, University Medical Center Utrecht, The Netherlands
    Neurology 82:777-83. 2014
    ..Assuming the involvement of homocysteine in a generalized small-vessel disease, we investigated the association of homocysteine levels with progression of white matter lesions, lacunar infarcts, and kidney disease...
  18. doi request reprint Antidepressant use is related to larger white matter lesion volume in patients with symptomatic atherosclerotic disease: the SMART-MR study
    Anne M Grool
    Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Stratenum 6 131, PO Box 85500, 3508 GA, Utrecht, The Netherlands
    J Neurol 260:197-206. 2013
    ..Future studies are needed to determine whether this may be a direct effect, or whether other underlying diseases for which antidepressants are prescribed influence this relation...
  19. doi request reprint Depression, anxiety and physical function: exploring the strength of causality
    Bauke T Stegenga
    Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, The Netherlands
    J Epidemiol Community Health 66:e25. 2012
    ..Depression, anxiety and physical function may be bi-directionally related. We aim to estimate the strength of the longitudinal associations between depression, anxiety and physical function...
  20. doi request reprint Vascular brain lesions, brain atrophy, and cognitive decline. The Second Manifestations of ARTerial disease--Magnetic Resonance (SMART-MR) study
    Minke Kooistra
    Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, The Netherlands
    Neurobiol Aging 35:35-41. 2014
    ..Our findings suggest that in patients with symptomatic atherosclerotic disease, the combination of brain atrophy and WMLs or brain infarcts accelerates cognitive decline over 4 years...
  21. doi request reprint Blood pressure and progression of brain atrophy: the SMART-MR Study
    Hadassa M Jochemsen
    Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, The Netherlands
    JAMA Neurol 70:1046-53. 2013
    ..Yet, prospective evidence is limited, and the relation remains unclear in patients with manifest arterial disease...
  22. doi request reprint Does recognition of depression in primary care affect outcome? The PREDICT-NL study
    Marjolein H Kamphuis
    Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, The Netherlands
    Fam Pract 29:16-23. 2012
    ..Detection rates of depression in primary care are <50%. Studies showed similar outcome after 12 months for recognized and unrecognized depression. Outcome beyond 12 months is less well studied...
  23. doi request reprint Serum angiotensin-converting enzyme and recurrent vascular events. The SMART-MR study
    Hadassa M Jochemsen
    Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, The Netherlands
    Atherosclerosis 224:486-91. 2012
    ..However, little data are available on the association of direct measures of ACE activity with vascular risk and disease. We examined whether serum ACE levels were associated with the risk of recurrent vascular events...
  24. ncbi request reprint Total cerebral blood flow, white matter lesions and brain atrophy: the SMART-MR study
    Auke P A Appelman
    Department of Radiology, University Medical Center Utrecht, Utrecht, The Netherlands
    J Cereb Blood Flow Metab 28:633-9. 2008
    ..d. decrease in CBF 0.18%, 95% CI: 0.02 to 0.34%. Our findings suggest that cerebral hypoperfusion in the presence of WML may be associated with subcortical brain atrophy...
  25. doi request reprint Loss of entorhinal cortex and hippocampal volumes compared to whole brain volume in normal aging: the SMART-Medea study
    Arnoud J G Knoops
    University Medical Center Utrecht, Department of Radiology, Utrecht, The Netherlands
    Psychiatry Res 203:31-7. 2012
    ....
  26. doi request reprint Angiotensin-converting enzyme and progression of white matter lesions and brain atrophy--the SMART-MR study
    Hadassa M Jochemsen
    Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, The Netherlands
    J Alzheimers Dis 29:39-49. 2012
    ..This suggests both detrimental and beneficial effects of high ACE levels on the brain...
  27. doi request reprint Depression, hypothalamic pituitary adrenal axis, and hippocampal and entorhinal cortex volumes--the SMART Medea study
    Lotte Gerritsen
    Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, The Netherlands
    Biol Psychiatry 70:373-80. 2011
    ..We investigated the association of MDD and history of depression with hippocampal and entorhinal cortex volumes and whether HPA axis activity explained this association...
  28. doi request reprint Cerebral small vessel disease and risk of death, ischemic stroke, and cardiac complications in patients with atherosclerotic disease: the Second Manifestations of ARTerial disease-Magnetic Resonance (SMART-MR) study
    Mandy M A Conijn
    Department of Radiology, UMC Utrecht, 3508 GA Utrecht, The Netherlands
    Stroke 42:3105-9. 2011
    ..We assessed whether lacunar infarcts and white matter lesions on MRI increased the risk of vascular and nonvascular death and future vascular events in patients with atherosclerotic disease...
  29. doi request reprint APOE ε4 differentially influences change in memory performance depending on age. The SMART-MR study
    Hadassa M Jochemsen
    University Medical Center Utrecht, Julius Center for Health Sciences and Primary Care, Utrecht, The Netherlands
    Neurobiol Aging 33:832.e15-22. 2012
    ..25; 95% CI, -0.52 to 0.01). Our findings suggest that the APOE ε4 allele has a differential effect on change in verbal memory performance depending on age, consistent with the hypothesis of antagonistic pleiotropy...
  30. doi request reprint A clinical prediction rule for detecting major depressive disorder in primary care: the PREDICT-NL study
    Nicolaas P A Zuithoff
    Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, 3508 GA Utrecht, The Netherlands
    Fam Pract 26:241-50. 2009
    ..Major depressive disorder often remains unrecognized in primary care...
  31. doi request reprint Lacunar infarcts in deep white matter are associated with higher and more fluctuating depressive symptoms during three years follow-up
    Anne M Grool
    Julius Center for Health Sciences and Primary Care, Department of Radiology, University Medical Center Utrecht, Utrecht, The Netherlands
    Biol Psychiatry 73:169-76. 2013
    ..We examined the influence of lacunar infarcts and white matter lesions (WML) on severity and course of depressive symptoms during 3 years follow-up...
  32. doi request reprint Salivary cortisol, APOE-ε4 allele and cognitive decline in a prospective study of older persons
    Lotte Gerritsen
    University Medical Center Utrecht, Julius Center for Health Sciences and Primary Care, The Netherlands
    Neurobiol Aging 32:1615-25. 2011
    ..We determined whether salivary cortisol levels were associated with cognitive decline at follow-up in older persons and whether this association was modified by the APOE-ε4 allele...
  33. doi request reprint A comorbid anxiety disorder does not result in an excess risk of death among patients with a depressive disorder
    Wijnand Laan
    Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, The Netherlands
    J Affect Disord 135:284-91. 2011
    ..Mortality due to comorbidity of two mental disorders may be even more increased. Therefore, we investigated the mortality among patients with depression, with anxiety and with both diagnoses...
  34. ncbi request reprint Autonomic dysfunction: a link between depression and cardiovascular mortality? The FINE Study
    Marjolein H Kamphuis
    Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, The Netherlands
    Eur J Cardiovasc Prev Rehabil 14:796-802. 2007
    ..Depression is associated with an increased risk of cardiovascular diseases (CVD) in vascular patients as well as in the general population. We investigated whether autonomic dysfunction could explain this relationship...
  35. ncbi request reprint Association of white matter lesions and lacunar infarcts with executive functioning: the SMART-MR study
    Mirjam I Geerlings
    Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, The Netherlands
    Am J Epidemiol 170:1147-55. 2009
    ..Both were not associated with worse memory. Results suggest that subcortical ischemic vascular lesions are associated with decreased executive functioning, but not with memory functioning, independent of brain atrophy...
  36. doi request reprint Diabetes mellitus and progression of vascular brain lesions and brain atrophy in patients with symptomatic atherosclerotic disease. The SMART-MR study
    Minke Kooistra
    Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, The Netherlands
    J Neurol Sci 332:69-74. 2013
    ..We assessed whether DM increased the rate of progression of brain atrophy, vascular brain lesions, and cognitive decline in patients with symptomatic atherosclerotic disease...
  37. doi request reprint Microbleeds, lacunar infarcts, white matter lesions and cerebrovascular reactivity -- a 7 T study
    Mandy M A Conijn
    Department of Radiology, University Medical Center Utrecht, PO Box 85500, 3508 GA, Utrecht, The Netherlands
    Neuroimage 59:950-6. 2012
    ....
  38. doi request reprint White matter lesions and brain atrophy: more than shared risk factors? A systematic review
    Auke P A Appelman
    Department of Radiology, University Medical Center Utrecht, Utrecht, The Netherlands
    Cerebrovasc Dis 28:227-42. 2009
    ....
  39. doi request reprint Age-related changes in hypothalamic-pituitary-adrenal axis activity in patients with manifest arterial disease
    Arnoud J G Knoops
    University Medical Center Utrecht, Julius Center for Health Sciences and Primary Care, Stratenum 6 131, PO Box 85500, 3508 GA, Utrecht, The Netherlands
    Endocrine 37:231-8. 2010
    ..02) and higher mean cortisol after dexamethasone (β log transformed = 0.01; 95%CI 0.002-0.02). In patients with arterial disease, HPA axis activity showed reduced variability with older age, independent of cardiovascular risk factors...
  40. ncbi request reprint Unpredictable bias when using the missing indicator method or complete case analysis for missing confounder values: an empirical example
    Mirjam J Knol
    Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Str 6 131, PO Box 85500, 3508 GA Utrecht, The Netherlands
    J Clin Epidemiol 63:728-36. 2010
    ..Using empirical data, we demonstrated the degree and direction of bias in the effect estimate when using these methods compared with multiple imputation (MI)...
  41. doi request reprint Blood pressure and progression of cerebral atrophy in patients with vascular disease
    Anneloes L M Vlek
    Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, The Netherlands
    Am J Hypertens 22:1183-9. 2009
    ..This study aimed to assess the progression of cerebral atrophy and to evaluate possible associations with blood pressure (BP) in patients with pre-existing vascular disease...
  42. doi request reprint Visual rating of the hippocampus in non-demented elders: Does it measure hippocampal atrophy or other indices of brain atrophy? The SMART-MR study
    Arnoud J G Knoops
    Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, The Netherlands
    Hippocampus 19:1115-22. 2009
    ..001), and the GMF decreased with increasing HCSF score (P = 0.008). In this nondemented population, visual rating of the medial temporal lobe reflects hippocampal atrophy as well as global and subcortical atrophy...
  43. doi request reprint Risk factors for onset of multiple or long major depressive episodes versus single and short episodes
    Bauke T Stegenga
    Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Stratenum 6 131, P O Box 85500, 3508 GA, Utrecht, The Netherlands
    Soc Psychiatry Psychiatr Epidemiol 48:1067-75. 2013
    ..Major depressive disorder may vary according to number and duration of episodes. It is unclear whether risk factors for onset of multiple or long episodes of depression (MDE) differ from risk factors for the onset of single and short ones...
  44. pmc The Patient Health Questionnaire-9 for detection of major depressive disorder in primary care: consequences of current thresholds in a crosssectional study
    Nicolaas P A Zuithoff
    University Medical Center Utrecht, Julius Center for Health Sciences and Primary Care, The Netherlands
    BMC Fam Pract 11:98. 2010
    ..In this study, we present the reliability, construct validity and accuracy of the PHQ-9 and PHQ-2 to detect major depressive disorder in primary care...
  45. doi request reprint Unexpected lower prevalence of depression in patients with diabetes: selection bias in a waiting room population
    Miriam J Knol
    Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, The Netherlands
    Epidemiology 20:419-23. 2009
    ..We initially studied the association between diabetes and depression in general practice attendees. Subsequently, we investigated whether our findings were influenced by selection bias...
  46. ncbi request reprint Physical inactivity, depression, and risk of cardiovascular mortality
    Marjolein H Kamphuis
    Julius Center for Health Sciences and Primary Care, University Medical Center, Utrecht, The Netherlands
    Med Sci Sports Exerc 39:1693-9. 2007
    ..One of the hypotheses to explain this relation is that depressed subjects become physically inactive. We set out to determine the role of physical inactivity in the relation between depressive symptoms and cardiovascular mortality...
  47. doi request reprint Efficient detection of cerebral microbleeds on 7.0 T MR images using the radial symmetry transform
    Hugo J Kuijf
    Image Sciences Institute, University Medical Center Utrecht, Utrecht, The Netherlands
    Neuroimage 59:2266-73. 2012
    ..The RST outperforms published semi-automated methods in terms of either a higher sensitivity or less false positives, and requires much less human rater time...
  48. doi request reprint Mood problems increase the risk of mortality in patients with lacunar infarcts: the SMART-MR study
    Anne M Grool
    Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Stratenum 6 131, PO Box 85500, 3508 GA Utrecht, The Netherlands
    Psychosom Med 74:234-40. 2012
    ..We investigated the influence of cerebral small vessel disease (CSVD), characterized by white matter lesions (WMLs) and lacunar infarcts, on the relationship between mood mortality during 6 years follow-up...
  49. pmc Perforating arteries originating from the posterior communicating artery: a 7.0-Tesla MRI study
    Mandy M A Conijn
    Department of Radiology, University Medical Center Utrecht, The Netherlands
    Eur Radiol 19:2986-92. 2009
    ....
  50. ncbi request reprint Estimating interaction on an additive scale between continuous determinants in a logistic regression model
    Mirjam J Knol
    Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, The Netherlands
    Int J Epidemiol 36:1111-8. 2007
    ..The objective of the present study was to provide the methods to estimate interaction between continuous determinants and to illustrate these methods with a clinical example...
  51. doi request reprint Personality characteristics and hypothalamic-pituitary-adrenal axis regulation in older persons
    Lotte Gerritsen
    Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, The Netherlands
    Am J Geriatr Psychiatry 17:1077-84. 2009
    ..To investigate the cross-sectional association between personality characteristics and hypothalamic-pituitary-adrenal (HPA) axis regulation in older persons...
  52. ncbi request reprint Brain volumes and risk of cardiovascular events and mortality. The SMART-MR study
    Pieternella H van der Veen
    Department of Radiology, University Medical Center Utrecht, Utrecht, The Netherlands Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, The Netherlands
    Neurobiol Aging 35:1624-31. 2014
    ..35-2.13), and ischemic stroke (HR 1.96, 95% CI: 1.43-2.69), independent of cardiovascular risk factors. These results suggest that brain volumes are an important determinant of poor outcome in patients with high cardiovascular risk...
  53. doi request reprint Longitudinal changes in brain volumes and cerebrovascular lesions on MRI in patients with manifest arterial disease: the SMART-MR study
    Pieternella H van der Veen
    Department of Radiology, University Medical Center Utrecht, The Netherlands Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, The Netherlands
    J Neurol Sci 337:112-8. 2014
    ..Additionally, patients with cerebrovascular and peripheral arterial disease showed the most prominent progression of atrophy and lesions...
  54. pmc Reporting and methods in clinical prediction research: a systematic review
    Walter Bouwmeester
    Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, The Netherlands
    PLoS Med 9:1-12. 2012
    ..We investigated the reporting and methods of prediction studies, focusing on aims, designs, participant selection, outcomes, predictors, statistical power, statistical methods, and predictive performance measures...
  55. doi request reprint Schizophrenia risk factors constitute general risk factors for psychiatric symptoms in the population
    Elemi J Breetvelt
    Rudolf Magnus Institute of Neuroscience, Department of Psychiatry, University Medical Center Utrecht, Utrecht, The Netherlands
    Schizophr Res 120:184-90. 2010
    ..However, to our knowledge no large-scale studies have been conducted which examine the specificity of these risk factors in the general population...
  56. doi request reprint Homocysteine and cerebral small vessel disease in patients with symptomatic atherosclerotic disease. The SMART-MR study
    Raoul P Kloppenborg
    Department of Neurology, Academic Medical Center, Amsterdam, The Netherlands
    Atherosclerosis 216:461-6. 2011
    ..We evaluated the association between homocysteine and cSVD in a large cohort of patients with symptomatic atherosclerotic disease...
  57. ncbi request reprint Depression and cardiovascular mortality: a role for n-3 fatty acids?
    Marjolein H Kamphuis
    Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, Netherlands
    Am J Clin Nutr 84:1513-7. 2006
    ..Recent studies indicate that depression plays an important role in the occurrence of cardiovascular diseases (CVDs). The underlying mechanisms are not well understood...
  58. ncbi request reprint Depressive symptoms as risk factor of cardiovascular mortality in older European men: the Finland, Italy and Netherlands Elderly (FINE) study
    Marjolein H Kamphuis
    Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht The Netherlands
    Eur J Cardiovasc Prev Rehabil 13:199-206. 2006
    ..We investigated to what extent depressive symptoms are a true risk factor for cardiovascular mortality in elderly men...
  59. ncbi request reprint Hippocampal subfield volumes at 7T in early Alzheimer's disease and normal aging
    Laura E M Wisse
    Department of Neurology, Brain Center Rudolf Magnus, UMC Utrecht, Utrecht, The Netherlands Julius Center for Health Sciences and Primary Care, UMC Utrecht, Utrecht, The Netherlands
    Neurobiol Aging 35:2039-45. 2014
    ..Future, larger studies should determine which subfields are affected earliest in the disease process and what mechanisms underlie the volume loss. ..
  60. pmc Cortical microinfarcts on 7T MRI in patients with spontaneous intracerebral hemorrhage
    Susanne J van Veluw
    Department of Neurology and Neurosurgery, Brain Center Rudolf Magnus, University Medical Center Utrecht, Utrecht, The Netherlands
    J Cereb Blood Flow Metab 34:1104-6. 2014
    ..This explorative study shows, for the first time, that microinfarcts appear to be a very common vascular comorbidity in spontaneous ICH. Future larger studies should further assess the etiological significance of these lesions. ..
  61. ncbi request reprint Depressive symptoms in subjects with diagnosed and undiagnosed type 2 diabetes
    Mirjam J Knol
    Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, Netherlands
    Psychosom Med 69:300-5. 2007
    ..To investigate if disturbed glucose homeostasis or known diagnosis of diabetes was associated with depressive symptoms. The reason for the increased prevalence of depression in patients with Type 2 diabetes mellitus (DM2) is unknown...
  62. pmc The psychiatric case register middle Netherlands
    Hugo M Smeets
    Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, The Netherlands
    BMC Psychiatry 11:106. 2011
    ..In 2010 the follow-up period was over ten years. In this paper we describe the content, aims and research potential of this case register...
  63. ncbi request reprint When one depends on the other: reporting of interaction in case-control and cohort studies
    Mirjam J Knol
    Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Netherlands
    Epidemiology 20:161-6. 2009
    ..We did a survey of epidemiologic studies published in leading journals to examine how interaction is assessed and reported...
  64. doi request reprint Visualization of cerebral microbleeds with dual-echo T2*-weighted magnetic resonance imaging at 7.0 T
    Mandy M A Conijn
    Department of Radiology, University Medical Center Utrecht, Utrecht, Netherlands
    J Magn Reson Imaging 32:52-9. 2010
    ..To assess the visualization of cerebral microbleeds with dual echo T2*-weighted imaging at 7.0 T magnetic resonance imaging (MRI)...
  65. doi request reprint Prevalence of common mental disorders in general practice attendees across Europe
    Michael King
    Department of Mental Health Sciences, Royal Free and University College Medical School, London, UK
    Br J Psychiatry 192:362-7. 2008
    ..There is evidence that the prevalence of common mental disorders varies across Europe...
  66. ncbi request reprint Use of hippocampal and amygdalar volumes on magnetic resonance imaging to predict dementia in cognitively intact elderly people
    Tom den Heijer
    Department of Epidemiology and Biostatistics, Erasmus Medical Center, Rotterdam, The Netherlands
    Arch Gen Psychiatry 63:57-62. 2006
    ..Whether atrophy of these structures is also present in persons without cognitive impairment who later develop dementia is unknown...
  67. ncbi request reprint Dietary intake of antioxidants and risk of Alzheimer disease
    Marianne J Engelhart
    Department of Epidemiology and Biostatistics, Erasmus Medical Center, 3000 DR Rotterdam, The Netherlands
    JAMA 287:3223-9. 2002
    ..Therefore, the risk of Alzheimer disease might be reduced by intake of antioxidants that counteract the detrimental effects of oxidative stress...
  68. ncbi request reprint Low levels of endogenous androgens increase the risk of atherosclerosis in elderly men: the Rotterdam study
    A Elisabeth Hak
    Department of Epidemiology and Biostatistics, Erasmus Medical Center, 3000 CA Rotterdam, The Netherlands
    J Clin Endocrinol Metab 87:3632-9. 2002
    ..In women, positive associations between levels of testosterone and aortic atherosclerosis were largely due to adverse cardiovascular disease risk factors...
  69. ncbi request reprint Sex hormones and neuropathology in elderly men: the HAAS
    Dorothea Strozyk
    Laboratory of Epidemiology, Demography and Biometry, National Institutes on Aging, National Institutes of Health, Bethesda, MD 20892, USA
    Neurobiol Aging 28:62-8. 2007
    ..This community-based autopsy study suggests that peripheral levels of sex hormones are associated with neurofibrillary tangles and micro-infarcts, but not with other neuropathologic markers of brain disease in elderly men...
  70. ncbi request reprint Endogenous estradiol and risk of dementia in women and men: the Rotterdam Study
    Mirjam I Geerlings
    Department of Epidemiology and Biostatistics, Erasmus Medical Center, Rotterdam, The Netherlands
    Ann Neurol 53:607-15. 2003
    ..The findings do not support the hypothesis that higher levels of endogenous estradiol reduce risk of dementia, neither in women nor in men...
  71. ncbi request reprint Inflammatory proteins in plasma and the risk of dementia: the rotterdam study
    Marianne J Engelhart
    Department of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands
    Arch Neurol 61:668-72. 2004
    ..Increased levels of inflammatory proteins have been found in the brains and plasma samples of patients with dementia. Whether the levels of inflammatory proteins in plasma samples are elevated before clinical onset of dementia is unclear...
  72. ncbi request reprint Higher estrogen levels are not associated with larger hippocampi and better memory performance
    Tom den Heijer
    Department of Epidemiology, Erasmus MC, PO Box 1738, 3000 DR Rotterdam, The Netherlands
    Arch Neurol 60:213-20. 2003
    ..Animal study findings have shown beneficial effects of estrogen on the brain, particularly on the hippocampus, a structure related to memory performance and early Alzheimer disease...