Research Topics
Species | Ronald T GansevoortSummaryAffiliation: University Medical Center Groningen Country: The Netherlands Publications
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Publications
Evaluation of measures of urinary albumin excretionRonald T Gansevoort
Department of Nephrology, University Medical Center, Groningen, The Netherlands
Am J Epidemiol 164:725-7. 2006..Consequently, values for the within-person coefficient of variation will therefore be different when they are measured in a portion of a 24-hour urine collection in comparison with a spot morning urine sample...
Challenges for the present CKD classification systemRon T Gansevoort
Department of Nephrology, University Medical Center Groningen, Groningen, The Netherlands
Curr Opin Nephrol Hypertens 19:308-14. 2010..This classification system was immediately widely embraced. However, soon after its introduction concerns were expressed. In this review we discuss the major points of concern that have been brought forward...
Albuminuria: all you need to predict outcomes in chronic kidney disease?Ron T Gansevoort
Department of Nephrology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
Curr Opin Nephrol Hypertens 19:513-8. 2010..In current approaches, further evaluation will only include measurement of albuminuria in case of eGFR less than 60 ml/min/1.73 m. We will review whether this screening approach is correct...
Lower estimated GFR and higher albuminuria are associated with adverse kidney outcomes. A collaborative meta-analysis of general and high-risk population cohortsRon T Gansevoort
Department of Nephrology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
Kidney Int 80:93-104. 2011..Thus, lower eGFR and higher albuminuria are risk factors for ESRD, acute kidney injury and progressive CKD in both general and high-risk populations, independent of each other and of cardiovascular risk factors...
Glomerular and tubular damage markers are elevated in patients with diabetesFerdau L Nauta
Department of Nephrology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
Diabetes Care 34:975-81. 2011....
Development and validation of a general population renal risk scoreNynke Halbesma
Division of Nephrology, Department of Medicine, University Medical Center Groningen, University Hospital Groningen, Groningen, The Netherlands
Clin J Am Soc Nephrol 6:1731-8. 2011..73 m² during follow-up were defined as having progressive CKD. Possible predictors for progressive CKD were selected on the basis of univariable logistic regression analyses...
Do albuminuria and hs-CRP add to the International Diabetes Federation definition of the metabolic syndrome in predicting outcome?Marije van der Velde
Division of Nephrology, Department of Medicine, University Medical Center Groningen, University Hospital Groningen, Groningen, The Netherlands
Nephrol Dial Transplant 27:2275-83. 2012....
Gender differences in predictors of the decline of renal function in the general populationNynke Halbesma
Division of Nephrology, Department of Medicine, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
Kidney Int 74:505-12. 2008..These studies show that there are gender differences in the standard predictors of the decline in renal function...
Screening for albuminuria identifies individuals at increased renal riskMarije van der Velde
Division of Nephrology, Department of Internal Medicine, University Medical Center Groningen, Groningen, The Netherlands
J Am Soc Nephrol 20:852-62. 2009..Screening for albuminuria identifies patients at increased risk for progressive renal disease, 40 to 50% of whom were previously undiagnosed or untreated...
Urinary albumin excretion as a predictor of the development of hypertension in the general populationAuke H Brantsma
Division of Nephrology, Department of Medicine, University Medical Center Groningen, PO Box 30.001, Groningen, 9700 RB The Netherlands
J Am Soc Nephrol 17:331-5. 2006..In conclusion, these findings support the hypothesis that mild renal damage may precede the development of hypertension...
What predicts progression and regression of urinary albumin excretion in the nondiabetic population?Auke H Brantsma
Division of Nephrology, Department of Medicine, University Medical Center Groningen, PO Box 30 001, 9700 RB Groningen, The Netherlands
J Am Soc Nephrol 18:637-45. 2007....
Changes in renal risk factors versus renal function outcome during follow-up in a population-based cohort studyNynke Halbesma
Division of Nephrology, Department of Medicine, University Medical Center Groningen UMCG, University of Groningen, Groningen, The Netherlands
Nephrol Dial Transplant 25:1846-53. 2010..Therefore, the aim of this study was to investigate whether besides the baseline values of these risk factors, changes in risk factors are associated with subsequent rate of renal function loss...
Cardiovascular and renal outcome in subjects with K/DOQI stage 1-3 chronic kidney disease: the importance of urinary albumin excretionAuke H Brantsma
Division of Nephrology, Department of Internal Medicine, University Medical Center Groningen, Groningen, The Netherlands
Nephrol Dial Transplant 23:3851-8. 2008..In this study we evaluated cardiovascular and renal outcome in subjects with stage 1 and 2 CKD. For comparison, we also studied these outcomes in stage 3 CKD...
Extended prognostic value of urinary albumin excretion for cardiovascular eventsAuke H Brantsma
Division of Nephrology, Department of Medicine, University Medical Center Groningen, P O Box 30 001, 9700 RB Groningen, The Netherlands
J Am Soc Nephrol 19:1785-91. 2008..Future studies are required to determine the optimal interval of repeat testing and its cost-effectiveness...
Macroalbuminuria is a better risk marker than low estimated GFR to identify individuals at risk for accelerated GFR loss in population screeningNynke Halbesma
Division of Nephrology, Department of Medicine, University Medical Center Groningen, P.O. Box 30.001, 9700 RB Groningen, The Netherlands
J Am Soc Nephrol 17:2582-90. 2006..However, macroalbuminuria is a better risk marker than low eGFR or erythrocyturia to identify in population screening of individuals who are at risk for accelerated GFR loss...
Impact of weight change on albuminuria in the general populationAminu K Bello
Division of Nephrology, Department of Medicine, University Medical Center Groningen, 9700 RB Groningen, The Netherlands
Nephrol Dial Transplant 22:1619-27. 2007..The impact of weight change on albuminuria and its possible mechanism has not been studied yet in the general population. We investigated this issue in a cohort of the Northern European population...
Comparison of the yield of different screening approaches to detect chronic kidney diseaseMarije van der Velde
Division of Nephrology, Department of Internal Medicine, University Medical Center Groningen, Groningen, The Netherlands
Nephrol Dial Transplant 25:3222-30. 2010....
High protein intake associates with cardiovascular events but not with loss of renal functionNynke Halbesma
Division of Nephrology, Department of Medicine, University Medical Center Groningen, University Hospital Groningen, Groningen, Netherlands
J Am Soc Nephrol 20:1797-804. 2009..In summary, in the general population, high protein intake does not promote accelerated decline of renal function but does associate with an increased risk for cardiovascular events...
Selection on albuminuria enhances the efficacy of screening for cardiovascular risk factorsAkin Ozyilmaz
Division of Nephrology, Department of Medicine, University Medical Center Groningen and University of Groningen, Groningen, The Netherlands
Nephrol Dial Transplant 25:3560-8. 2010..As albuminuria is easy to measure, we tested whether a screening approach in which detailed risk factor measurement is done only after selection of subjects with an elevated albuminuria results in a higher yield of subjects at risk...
Urinary albumin excretion and its relation with C-reactive protein and the metabolic syndrome in the prediction of type 2 diabetesAuke H Brantsma
Division of Nephrology, Department of Medicine, University Medical Center Groningen, P.O. Box 30, 001, 9700 RB, Groningen, Netherlands
Diabetes Care 28:2525-30. 2005..CONCLUSIONS: UAE predicts type 2 diabetes independent of the metabolic syndrome and other known risk markers of development of type 2 diabetes. The predictive value of UAE was modified by the level of CRP...
Effect of first myocardial ischemic event on renal functionWouter B A Eijkelkamp
Department of Clinical Pharmacology, Division of Nephrology, University Medical Center Groningen, Groningen, The Netherlands
Am J Cardiol 100:7-12. 2007....
Apparent loss of urinary albumin during long-term frozen storage: HPLC vs immunonephelometryJacoline W Brinkman
Department of Clinical Pharmacology, University Medical Center Groningen and University of Groningen, Groningen, The Netherlands
Clin Chem 53:1520-6. 2007..We investigated whether this technique is affected by sample temperature, particularly freezing...
Urinary vitamin D binding protein: a potential novel marker of renal interstitial inflammation and fibrosisKatarina Mirković
Department of Internal Medicine, Division of Nephrology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands
PLoS ONE 8:e55887. 2013..20, p = 0.005), independently of albuminuria. UVDBP may be a novel urinary biomarker of tubulointerstitial damage. Prospectively designed studies are required to validate our findings and confirm its relevance in the clinical setting...
Better understanding of ADPKD results in potential new treatment options: ready for the cure?Esther Meijer
Division of Nephrology, Department of Internal Medicine, University Medical Center Groningen, Groningen, The Netherlands
J Nephrol 21:133-8. 2008..Clinical trials have been started to investigate the efficacy and safety of these agents for treating ADPKD in humans...
Therapeutic potential of vasopressin V2 receptor antagonist in a mouse model for autosomal dominant polycystic kidney disease: optimal timing and dosing of the drugE Meijer
Division of Nephrology, Department of Internal Medicine, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
Nephrol Dial Transplant 26:2445-53. 2011..We questioned whether we could reduce the side effects without influencing the renoprotective effect by starting the treatment later in the disease or by lowering drug dosage...
Copeptin, a surrogate marker of vasopressin, is associated with disease severity in autosomal dominant polycystic kidney diseaseEsther Meijer
Division of Nephrology, Department of Internal Medicine, University Medical Center Groningen, PO Box 30 001, 9700 RB Groningen, The Netherlands
Clin J Am Soc Nephrol 6:361-8. 2011..However, it is unknown whether endogenous vasopressin concentration is associated with disease severity in patients with ADPKD...
Prolonged frozen storage of urine reduces the value of albuminuria for mortality predictionJacoline W Brinkman
Clin Chem 53:153-4. 2007
Falsely low urinary albumin concentrations after prolonged frozen storage of urine samplesJacoline W Brinkman
Department of Clinical Pharmacology, University of Groningen and University Medical Center Groningen, The Netherlands
Clin Chem 51:2181-3. 2005
Urinary pH affects albumin concentrations after prolonged frozen storageJacoline W Brinkman
Nephrol Dial Transplant 22:3670. 2007
