M R Fokkema

Summary

Affiliation: University Hospital Groningen
Country: The Netherlands

Publications

  1. ncbi Polyunsaturated fatty acid status of Dutch vegans and omnivores
    M R Fokkema
    Department of Pathology and Laboratory Medicine, Groningen University Hospital, Groningen, The Netherlands
    Prostaglandins Leukot Essent Fatty Acids 63:279-85. 2000
  2. ncbi Short-term carnitine supplementation does not augment LCPomega3 status of vegans and lacto-ovo-vegetarians
    M Rebecca Fokkema
    Department of Pathology and Laboratory Medicine, University Hospital Groningen, CMC V, Room Y1 165, PO Box 30 001, NL 9700 RB Groningen, The Netherlands
    J Am Coll Nutr 24:58-64. 2005
  3. ncbi Assessment of essential fatty acid and omega3-fatty acid status by measurement of erythrocyte 20:3omega9 (Mead acid), 22:5omega6/20:4omega6 and 22:5omega6/22:6omega3
    M R Fokkema
    Department of Pathology and Laboratory Medicine, Groningen University Hospital, The Netherlands
    Prostaglandins Leukot Essent Fatty Acids 67:345-56. 2002
  4. ncbi Plasma total homocysteine increases from day 20 to 40 in breastfed but not formula-fed low-birthweight infants
    M R Fokkema
    Department of Pathology and Laboratory Medicine, Groningen University Hospital, The Netherlands
    Acta Paediatr 91:507-11. 2002
  5. ncbi Influence of vitamin-optimized plasma homocysteine cutoff values on the prevalence of hyperhomocysteinemia in healthy adults
    M R Fokkema
    Department of Pathology and Laboratory Medicine, University Hospital Groningen, NL 9700 RB Groningen, The Netherlands
    Clin Chem 47:1001-7. 2001
  6. ncbi Short-term supplementation of low-dose gamma-linolenic acid (GLA), alpha-linolenic acid (ALA), or GLA plus ALA does not augment LCP omega 3 status of Dutch vegans to an appreciable extent
    M R Fokkema
    Department of Pathology and Laboratory Medicine, Groningen University Hospital, Groningen, The Netherlands
    Prostaglandins Leukot Essent Fatty Acids 63:287-92. 2000
  7. ncbi Low diagnostic value of fasting and post-methionine load homocysteine tests. A study in Dutch subjects with homocysteine test indications
    M R Fokkema
    Department of Pathology and Laboratory Medicine, University Hospital Groningen, CMC-V, Room Y1.165, P.O. Box 30.001, NL-9700 RB, Groningen, The Netherlands
    Clin Chim Acta 331:153-7. 2003
  8. ncbi Low essential fatty acid and B-vitamin status in a subgroup of patients with schizophrenia and its response to dietary supplementation
    R F J Kemperman
    Department of Pathology and Laboratory Medicine, CMC V, Room Y3 181, University Medical Center Groningen, P O Box 30 001, 9700 RB Groningen, The Netherlands
    Prostaglandins Leukot Essent Fatty Acids 74:75-85. 2006
  9. ncbi Fasting vs nonfasting plasma homocysteine concentrations for diagnosis of hyperhomocysteinemia
    M Rebecca Fokkema
    Departments of Pathology and Laboratory Medicine, University Hospital Groningen, NL-9700 RB Groningen, The Netherlands
    Clin Chem 49:818-21. 2003
  10. ncbi Controlled study on folate status following folic acid supplementation and discontinuation in women of child-bearing age
    D Joyce Bakker
    Department of Pathology and Laboratory Medicine, University Medical Center Groningen, Groningen, The Netherlands
    Ann Clin Biochem 46:231-4. 2009

Collaborators

Detail Information

Publications20

  1. ncbi Polyunsaturated fatty acid status of Dutch vegans and omnivores
    M R Fokkema
    Department of Pathology and Laboratory Medicine, Groningen University Hospital, Groningen, The Netherlands
    Prostaglandins Leukot Essent Fatty Acids 63:279-85. 2000
    ..Higher 18:3 omega 6 and 20:3 omega 6 in their TG may reflect higher hepatic 20:4 omega 6 production rate, whereas higher 20:4 omega 6 and 22:4 omega 6 in omnivores indicates 20:4 omega 6 intake from meat...
  2. ncbi Short-term carnitine supplementation does not augment LCPomega3 status of vegans and lacto-ovo-vegetarians
    M Rebecca Fokkema
    Department of Pathology and Laboratory Medicine, University Hospital Groningen, CMC V, Room Y1 165, PO Box 30 001, NL 9700 RB Groningen, The Netherlands
    J Am Coll Nutr 24:58-64. 2005
    ..We investigated whether carnitine supplementation augments the LCPomega3 status of apparently healthy vegans and lacto-ovo-vegetarians, who are expected to have low carnitine status...
  3. ncbi Assessment of essential fatty acid and omega3-fatty acid status by measurement of erythrocyte 20:3omega9 (Mead acid), 22:5omega6/20:4omega6 and 22:5omega6/22:6omega3
    M R Fokkema
    Department of Pathology and Laboratory Medicine, Groningen University Hospital, The Netherlands
    Prostaglandins Leukot Essent Fatty Acids 67:345-56. 2002
    ..We determined cut-off values for biochemical EFAD, omega3-and omega3/22:6omega3 [docosahexaenoic acid (DHA)]-deficiency by measurement of erythrocyte 20:3omega9 (Mead acid), 22:5omega6/20:4omega6 and 22:5omega6/22:6omega3, respectively...
  4. ncbi Plasma total homocysteine increases from day 20 to 40 in breastfed but not formula-fed low-birthweight infants
    M R Fokkema
    Department of Pathology and Laboratory Medicine, Groningen University Hospital, The Netherlands
    Acta Paediatr 91:507-11. 2002
    ..7) micromol l(-1). Conclusion: Increasing plasma total homocysteine in breastfed babies to higher levels compared with formula-fed babies may be caused by a gradually developing suboptimal B-vitamin status in lactating women...
  5. ncbi Influence of vitamin-optimized plasma homocysteine cutoff values on the prevalence of hyperhomocysteinemia in healthy adults
    M R Fokkema
    Department of Pathology and Laboratory Medicine, University Hospital Groningen, NL 9700 RB Groningen, The Netherlands
    Clin Chem 47:1001-7. 2001
    ..Results were compared with those obtained using European Concerted Action Project (ECAP) cutoff values...
  6. ncbi Short-term supplementation of low-dose gamma-linolenic acid (GLA), alpha-linolenic acid (ALA), or GLA plus ALA does not augment LCP omega 3 status of Dutch vegans to an appreciable extent
    M R Fokkema
    Department of Pathology and Laboratory Medicine, Groningen University Hospital, Groningen, The Netherlands
    Prostaglandins Leukot Essent Fatty Acids 63:287-92. 2000
    ..The reach of a DHA plateau already at low dietary ALA intakes suggests that dietary DHA causes a non-functional DHA surplus, or is, alternatively, important for maintaining DHA status at a functionally relevant level...
  7. ncbi Low diagnostic value of fasting and post-methionine load homocysteine tests. A study in Dutch subjects with homocysteine test indications
    M R Fokkema
    Department of Pathology and Laboratory Medicine, University Hospital Groningen, CMC-V, Room Y1.165, P.O. Box 30.001, NL-9700 RB, Groningen, The Netherlands
    Clin Chim Acta 331:153-7. 2003
    ..CONCLUSIONS: Employment of a 10 micro mol/l (American Heart Association) or 9.3 micro mol/l (vitamin-optimized reference) cut-off value leaves no indications for tHcy testing from an evidence-based point-of-view...
  8. ncbi Low essential fatty acid and B-vitamin status in a subgroup of patients with schizophrenia and its response to dietary supplementation
    R F J Kemperman
    Department of Pathology and Laboratory Medicine, CMC V, Room Y3 181, University Medical Center Groningen, P O Box 30 001, 9700 RB Groningen, The Netherlands
    Prostaglandins Leukot Essent Fatty Acids 74:75-85. 2006
    ..Correction seems indicated in view of the possible relation of poor EFA and B-vitamin status with some of their psychiatric symptoms, but notably to reduce their high risk of cardiovascular disease...
  9. ncbi Fasting vs nonfasting plasma homocysteine concentrations for diagnosis of hyperhomocysteinemia
    M Rebecca Fokkema
    Departments of Pathology and Laboratory Medicine, University Hospital Groningen, NL-9700 RB Groningen, The Netherlands
    Clin Chem 49:818-21. 2003
  10. ncbi Controlled study on folate status following folic acid supplementation and discontinuation in women of child-bearing age
    D Joyce Bakker
    Department of Pathology and Laboratory Medicine, University Medical Center Groningen, Groningen, The Netherlands
    Ann Clin Biochem 46:231-4. 2009
    ..We studied FA kinetics up to 12 weeks discontinuation of eight weeks 500 microg/d FA in 27 healthy Dutch women of child-bearing age...
  11. ncbi Is docosahexaenoic acid (DHA) essential? Lessons from DHA status regulation, our ancient diet, epidemiology and randomized controlled trials
    Frits A J Muskiet
    Pathology and Laboratory Medicine, Groningen University Hospital, The Netherlands
    J Nutr 134:183-6. 2004
  12. ncbi High contents of both docosahexaenoic and arachidonic acids in milk of women consuming fish from lake Kitangiri (Tanzania): targets for infant formulae close to our ancient diet?
    Remko S Kuipers
    Pathology and Laboratory Medicine, Groningen University Hospital, CMC V, Room Y 1 165, P O Box 30 001, 9700 RB Groningen, The Netherlands
    Prostaglandins Leukot Essent Fatty Acids 72:279-88. 2005
    ..We conclude that the milk AA, DHA and EPA contents of Doromoni women might provide us with clues to optimize infant formulae and perhaps the milk of Western women...
  13. ncbi Plasma choline and betaine and their relation to plasma homocysteine in normal pregnancy
    Francien V Velzing-Aarts
    Pathology and Laboratory Medicine, Groningen University Hospital, Groningen, Netherlands
    Am J Clin Nutr 81:1383-9. 2005
    ..Plasma concentrations of total homocysteine (tHcy) decrease during pregnancy. This reduction has been investigated in relation to folate status, but no study has addressed the possible role of betaine and its precursor choline...
  14. ncbi Increased intima-media thickness after early-onset preeclampsia
    Judith Blaauw
    Department of Obstetrics and Gynecology, University Medical Center Groningen, Groningen, The Netherlands
    Obstet Gynecol 107:1345-51. 2006
    ..The association between increased IMT and (preeclamptic) pregnancy leads to the question of which comes first, which should be addressed in follow-up studies. LEVEL OF EVIDENCE: II-2...
  15. ncbi Maternal and fetal brain contents of docosahexaenoic acid (DHA) and arachidonic acid (AA) at various essential fatty acid (EFA), DHA and AA dietary intakes during pregnancy in mice
    Saskia A van Goor
    Department of Pathology and Laboratory Medicine, University Medical Center Groningen, Groningen, The Netherlands
    Prostaglandins Leukot Essent Fatty Acids 78:159-69. 2008
    ..The inverse relationship between fetal brain AA and DHA suggests the need of a maternal dietary DHA/AA balance, at least in mice...
  16. ncbi The effects on plasma, red cell and platelet fatty acids of taking 12 g/day of ethyl-eicosapentaenoate for 16 months: dihomogammalinolenic, arachidonic and docosahexaenoic acids and relevance to Inuit metabolism
    David Horrobin
    Laxdale Ltd, Kings Park House, Laurelhill Business Park, Stirling, FK7 9JQ, Scotland, UK
    Prostaglandins Leukot Essent Fatty Acids 68:301-4. 2003
    ..The implications for understanding of fatty acid metabolism in humans are discussed...
  17. ncbi Optimization of folic acid, vitamin B(12), and vitamin B(6) supplements in pediatric patients with sickle cell disease
    Fey P L van der Dijs
    Analytic Diagnostic Center, , The Netherlands Antilles
    Am J Hematol 69:239-46. 2002
    ..5-5 U.S. 1998 RDA), and 6 mg vitamin B(6) (4.6-10 U.S. 1998 RDA). This combination may by simple and relatively inexpensive means reduce these patients' inherently high risk of endothelial damage...
  18. ncbi Reference change values for brain natriuretic peptides revisited
    M Rebecca Fokkema
    Clin Chem 52:1602-3. 2006
  19. ncbi Erythrocyte membrane fatty acids in benign and progressive forms of multiple sclerosis
    Marcus Koch
    Department of Neurology, University Medical Center Groningen, Hanzeplein 1, 9713 GZ Groningen, The Netherlands
    J Neurol Sci 244:123-6. 2006
    ..There is no good explanation why a proportion of patients with multiple sclerosis (MS) have a relatively benign form of the disease. An imbalance between saturated and unsaturated fatty acids (FA) might influence the disease course of MS...
  20. ncbi Higher erythrocyte 22:6n-3 and 22:5n-6, and lower 22:5n-3 suggest higher Delta-4-desaturation capacity in women of childbearing age
    Ella N Smit
    Br J Nutr 89:739-40. 2003