C G Figdor

Summary

Affiliation: University of Nijmegen
Country: The Netherlands

Publications

  1. ncbi request reprint How C-type lectins detect pathogens
    Alessandra Cambi
    Department of Tumor Immunology, Nijmegen Centre for Molecular Life Sciences, Radboud University, Nijmegen, The Netherlands
    Cell Microbiol 7:481-8. 2005
  2. ncbi request reprint C-type lectin receptors on dendritic cells and Langerhans cells
    Carl G Figdor
    Department of Tumor Immunology, Nijmegen Centre for Molecular Life Sciences, NCMLS 187 TIL, Postbox 9101, 6500HB Nijmegen, The Netherlands
    Nat Rev Immunol 2:77-84. 2002
  3. ncbi request reprint Molecular characterization of dendritic cells operating at the interface of innate or acquired immunity
    C G Figdor
    Department of Immunology, Nijmegen Center for Molecular Life Sciences, NCMLS 187 Til University Medical Center Postbox 9101, 6500 HB The, Nijmegen, Netherlands
    Pathol Biol (Paris) 51:61-3. 2003
  4. ncbi request reprint DC-SIGN, a dentritic cell-specific HIV-1 receptor present in placenta that infects T cells in trans-a review
    T B Geijtenbeek
    Department of Tumor Immunology, University Medical Center St Radboud, Philips van Leydenlaan 25, Nijmegen, 6525 EX, The Netherlands
    Placenta 22:S19-23. 2001
  5. ncbi request reprint DC-SIGN-ICAM-2 interaction mediates dendritic cell trafficking
    T B Geijtenbeek
    Department of Tumor Immunology, University Medical Center St Radboud, Philips van Leydenlaan 25, Nijmegen 6525 EX, The Netherlands
    Nat Immunol 1:353-7. 2000
  6. ncbi request reprint The dendritic cell-specific CC-chemokine DC-CK1 is expressed by germinal center dendritic cells and attracts CD38-negative mantle zone B lymphocytes
    E Lindhout
    Department of Tumor Immunology, University Medical Center, Nijmegen, The Netherlands
    J Immunol 166:3284-9. 2001
  7. ncbi request reprint A single amino acid in the cytoplasmic domain of the beta 2 integrin lymphocyte function-associated antigen-1 regulates avidity-dependent inside-out signaling
    D A Bleijs
    Department of Tumor Immunology, University Medical Center Nijmegen, Philips van Leydenlaan 25, Nijmegen 6525 EX, The Netherlands
    J Biol Chem 276:10338-46. 2001
  8. ncbi request reprint DC-SIGN, a dendritic cell-specific HIV-1-binding protein that enhances trans-infection of T cells
    T B Geijtenbeek
    Department of Tumor Immunology, University Medical Center St Radboud, Nijmegen, The Netherlands
    Cell 100:587-97. 2000
  9. ncbi request reprint Dynamic cell adhesion and migration on nanoscale grooved substrates
    E Lamers
    Department of Biomaterials, Radboud University Nijmegen Medical Centre 309 PB, PO Box 9101, 6500HB Nijmegen, The Netherlands
    Eur Cell Mater 23:182-93; discussion 193-4. 2012
  10. pmc Dendritic cell vaccination and immune monitoring
    E H J G Aarntzen
    Department of Medical Oncology, Nijmegen Centre for Molecular Life Sciences, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Cancer Immunol Immunother 57:1559-68. 2008

Collaborators

Detail Information

Publications88

  1. ncbi request reprint How C-type lectins detect pathogens
    Alessandra Cambi
    Department of Tumor Immunology, Nijmegen Centre for Molecular Life Sciences, Radboud University, Nijmegen, The Netherlands
    Cell Microbiol 7:481-8. 2005
    ..Moreover, the cross-talk of C-type lectins with other receptors, such as Toll-like receptors, will be discussed, highlighting the emerging model that microbial recognition is based on a complex network of interacting receptors...
  2. ncbi request reprint C-type lectin receptors on dendritic cells and Langerhans cells
    Carl G Figdor
    Department of Tumor Immunology, Nijmegen Centre for Molecular Life Sciences, NCMLS 187 TIL, Postbox 9101, 6500HB Nijmegen, The Netherlands
    Nat Rev Immunol 2:77-84. 2002
    ..It is now becoming clear that lectin receptors not only serve as antigen receptors but also regulate the migration of dendritic cells and their interaction with lymphocytes...
  3. ncbi request reprint Molecular characterization of dendritic cells operating at the interface of innate or acquired immunity
    C G Figdor
    Department of Immunology, Nijmegen Center for Molecular Life Sciences, NCMLS 187 Til University Medical Center Postbox 9101, 6500 HB The, Nijmegen, Netherlands
    Pathol Biol (Paris) 51:61-3. 2003
    ..ALCAM is linked to the cytoskeleton and might play a role in DC migration. Measurements of cell/cell contacts at single molecular levels using optical traps is a useful tool to investigate intercellular interactions...
  4. ncbi request reprint DC-SIGN, a dentritic cell-specific HIV-1 receptor present in placenta that infects T cells in trans-a review
    T B Geijtenbeek
    Department of Tumor Immunology, University Medical Center St Radboud, Philips van Leydenlaan 25, Nijmegen, 6525 EX, The Netherlands
    Placenta 22:S19-23. 2001
    ..The interaction of DC-SIGN with HIV gp120 may be an important target for therapeutic intervention and vaccine development...
  5. ncbi request reprint DC-SIGN-ICAM-2 interaction mediates dendritic cell trafficking
    T B Geijtenbeek
    Department of Tumor Immunology, University Medical Center St Radboud, Philips van Leydenlaan 25, Nijmegen 6525 EX, The Netherlands
    Nat Immunol 1:353-7. 2000
    ..Thus, DC-SIGN is central to the unusual trafficking capacity of DCs, further supported by the expression of DC-SIGN on precursors in blood and on immature and mature DCs in both peripheral and lymphoid tissues...
  6. ncbi request reprint The dendritic cell-specific CC-chemokine DC-CK1 is expressed by germinal center dendritic cells and attracts CD38-negative mantle zone B lymphocytes
    E Lindhout
    Department of Tumor Immunology, University Medical Center, Nijmegen, The Netherlands
    J Immunol 166:3284-9. 2001
    ..The findings that GCDC produce DC-CK1 and attract mantle zone B cells support a key role for GCDC in the development of GCs and memory B cell formation...
  7. ncbi request reprint A single amino acid in the cytoplasmic domain of the beta 2 integrin lymphocyte function-associated antigen-1 regulates avidity-dependent inside-out signaling
    D A Bleijs
    Department of Tumor Immunology, University Medical Center Nijmegen, Philips van Leydenlaan 25, Nijmegen 6525 EX, The Netherlands
    J Biol Chem 276:10338-46. 2001
    ....
  8. ncbi request reprint DC-SIGN, a dendritic cell-specific HIV-1-binding protein that enhances trans-infection of T cells
    T B Geijtenbeek
    Department of Tumor Immunology, University Medical Center St Radboud, Nijmegen, The Netherlands
    Cell 100:587-97. 2000
    ..We propose that DC-SIGN efficiently captures HIV-1 in the periphery and facilitates its transport to secondary lymphoid organs rich in T cells, to enhance infection in trans of these target cells...
  9. ncbi request reprint Dynamic cell adhesion and migration on nanoscale grooved substrates
    E Lamers
    Department of Biomaterials, Radboud University Nijmegen Medical Centre 309 PB, PO Box 9101, 6500HB Nijmegen, The Netherlands
    Eur Cell Mater 23:182-93; discussion 193-4. 2012
    ..From this study, we conclude that grooves with a pitch of 600 nm may be favourable to enhance fast wound closure, thereby promoting tissue regeneration...
  10. pmc Dendritic cell vaccination and immune monitoring
    E H J G Aarntzen
    Department of Medical Oncology, Nijmegen Centre for Molecular Life Sciences, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Cancer Immunol Immunother 57:1559-68. 2008
    ..Therefore, it is obvious that current DC-based protocols need to be improved. For this reason, we study in small proof of principle trials the fate, interactions and effectiveness of the injected DC...
  11. doi request reprint Dendritic cell vaccines in melanoma: from promise to proof?
    W J Lesterhuis
    Department of Medical Oncology, Nijmegen Centre for Molecular Life Sciences, Radboud University Nijmegen Medical Centre, PO Box 9101, 6500 HB Nijmegen, The Netherlands
    Crit Rev Oncol Hematol 66:118-34. 2008
    ..The different variables in preparing and administering DC vaccines are discussed in this context and the immunological and clinical results of studies with DC vaccines in melanoma patients are summarized...
  12. ncbi request reprint BLC (CXCL13) is expressed by different dendritic cell subsets in vitro and in vivo
    J L Vissers
    Department of Tumor Immunology, University Medical Center Nijmegen St Radboud, The Netherlands
    Eur J Immunol 31:1544-9. 2001
    ..Furthermore, CD40/CD40 ligand interactions could modulate this process by down-regulating the expression of BLC...
  13. pmc Dual-color superresolution microscopy reveals nanoscale organization of mechanosensory podosomes
    K van den Dries
    Department of Tumor Immunology, Nijmegen Centre for Molecular Life Sciences, Radboud University Nijmegen Medical Centre, 6500 HB Nijmegen, Netherlands
    Mol Biol Cell 24:2112-23. 2013
    ..Our findings call for a reevaluation of the current "core-ring" model and provide a novel structural framework for further understanding the collective behavior of podosome clusters. ..
  14. ncbi request reprint Genomic organization, chromosomal localization, and 5' upstream region of the human DC-STAMP gene
    F C Hartgers
    Department of Tumor Immunology, University Medical Center Nijmegen St Radbound, Research Tower, 5th Floor, Geert Grooteplein Zuid 28, 6525 GA Nijmegen, The Netherlands
    Immunogenetics 53:145-9. 2001
  15. doi request reprint A large-scale (19)F MRI-based cell migration assay to optimize cell therapy
    F Bonetto
    Department of Tumor Immunology, Nijmegen Center for Molecular Life Sciences, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands
    NMR Biomed 25:1095-103. 2012
    ..Hence, we show that the cell density in cell bolus injections has a decisive impact on migration, and this may explain the limited migration observed using large cell numbers in the clinic...
  16. ncbi request reprint The actin cytoskeleton regulates LFA-1 ligand binding through avidity rather than affinity changes
    Y van Kooyk
    Department of Tumor Immunology, University Hospital Nijmegen St Radboud, 6525 EX Nijmegen, The Netherlands
    J Biol Chem 274:26869-77. 1999
    ..From these data we conclude that LFA-1-mediated cell adhesion to ICAM-1 is predominantly regulated by receptor clustering and that affinity alterations do not necessarily coincide with strong ICAM-1 binding...
  17. ncbi request reprint Identification of DC-SIGN, a novel dendritic cell-specific ICAM-3 receptor that supports primary immune responses
    T B Geijtenbeek
    Department of Tumor Immunology, University Medical Center St Radboud, Nijmegen, The Netherlands
    Cell 100:575-85. 2000
    ..Since antibodies against DC-SIGN inhibit DC-induced proliferation of resting T cells, our findings predict that DC-SIGN enables T cell receptor engagement by stabilization of the DC-T cell contact zone...
  18. doi request reprint Targeting dendritic cells with antigen via dendritic cell-associated promoters
    V Moulin
    Department of Tumor Immunology, Nijmegen Centre for Molecular Life Sciences, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Cancer Gene Ther 19:303-11. 2012
    ..These experiments demonstrate that our DC-directed promoter constructs are potential tools to restrict antigen expression in DC and could be implemented to modulate DC function by the introduction of relevant proteins...
  19. ncbi request reprint Heme is a potent inducer of inflammation in mice and is counteracted by heme oxygenase
    F A Wagener
    Department of Tumor Immunology, University Medical Center Nijmegen, The Netherlands
    Blood 98:1802-11. 2001
    ....
  20. ncbi request reprint Avidity regulation of integrins: the driving force in leukocyte adhesion
    Y van Kooyk
    Department of Tumor Immunology, University Medical Center Nijmegen, St Radboud, P Van Leydenlaan 25, 6525 EX, The, Nijmegen, Netherlands
    Curr Opin Cell Biol 12:542-7. 2000
    ....
  21. pmc Efficient loading of dendritic cells following cryo and radiofrequency ablation in combination with immune modulation induces anti-tumour immunity
    M H M G M den Brok
    Department of Tumor Immunology, Nijmegen Centre for Molecular Life Sciences, Radboud University Nijmegen Medical Centre, PO Box 9101, Nijmegen 6500 HB, The Netherlands
    Br J Cancer 95:896-905. 2006
    ..Therefore, in situ tumour destruction in combination with immune modulation creates a unique, 'in situ DC-vaccine' that is readily applicable in the clinic without prior knowledge of tumour antigens...
  22. ncbi request reprint Quantitative analysis of chemokine expression by dendritic cell subsets in vitro and in vivo
    J L Vissers
    Department of Tumor Immunology, University Medical Center Nijmegen St. Radboud, Nijmegen, The Netherlands
    J Leukoc Biol 69:785-93. 2001
    ..These data indicate that different DC subsets in vitro and in vivo can express the same chemokines to attract leukocytes...
  23. doi request reprint Imaging of cellular therapies
    M Srinivas
    Department of Tumor Immunology, Nijmegen Centre for Molecular Life Sciences, The Netherlands
    Adv Drug Deliv Rev 62:1080-93. 2010
    ..Finally, we discuss future developments, including the emergence of multimodal imaging technology for cell tracking from the preclinical to the clinical realm...
  24. ncbi request reprint The Achilles' heel of HIV
    R Torensma
    Nijmegen Center for Molecular LifeSciences, Nijmegen, The Netherlands
    Med Hypotheses 58:386-7. 2002
    ..Blocking viral entry is another way to prevent viral spread. Here, we describe a method to block HIV entry by inhibiting the association of the two viral proteins that are involved in viral entry...
  25. ncbi request reprint The threshold at which substrate nanogroove dimensions may influence fibroblast alignment and adhesion
    W A Loesberg
    Radboud University Nijmegen Medical Centre, Department Periodontology and Biomaterials, THK 309, P O Box 9101, 6500 HB, Nijmegen, The Netherlands
    Biomaterials 28:3944-51. 2007
    ..We conclude that fibroblast cells cultured on nanotopography experience a threshold feature size of 35 nm, below this value contact guidance does no longer exist...
  26. pmc Interplay between myosin IIA-mediated contractility and actin network integrity orchestrates podosome composition and oscillations
    K van den Dries
    Department of Tumor Immunology, Radboud University Nijmegen Medical Centre, 6500 HB Nijmegen, The Netherlands
    Nat Commun 4:1412. 2013
    ..We demonstrate a previously unrecognized interplay between actin and myosin IIA in podosomes, providing novel mechanistic insights into how actomyosin-based structures allow dendritic cells to sense the extracellular environment...
  27. doi request reprint Targets for active immunotherapy against pediatric solid tumors
    J F M Jacobs
    Department of Pediatric Hemato Oncology, Radboud University Medical Centre Nijmegen, Nijmegen, The Netherlands
    Cancer Immunol Immunother 58:831-41. 2009
    ..In this review we discuss the current status of cancer immunotherapy in children, focusing on the identification of tumor-specific antigens on pediatric solid tumors...
  28. ncbi request reprint DC-STAMP, a novel multimembrane-spanning molecule preferentially expressed by dendritic cells
    F C Hartgers
    Department of Tumor Immunology, University Medical Center Nijmegen St Radboud, Nijmegen, The Netherlands
    Eur J Immunol 30:3585-90. 2000
    ..Therefore, we propose that DC-STAMP is a novel DC-specific multimembrane-spanning protein, representing a new group of transmembrane proteins...
  29. ncbi request reprint In situ detection of antigen-specific T cells in cryo-sections using MHC class I tetramers after dendritic cell vaccination of melanoma patients
    I J M de Vries
    Department of Tumor Immunology, Medical Oncology and Pediatric Hemato Oncology, Radboud University Nijmegen Medical Centre, Nijmegen Centre for Molecular Life Sciences, Nijmegen, The Netherlands
    Cancer Immunol Immunother 56:1667-76. 2007
    ....
  30. ncbi request reprint Modulation of integrin expression on rat bone marrow cells by substrates with different surface characteristics
    P J ter Brugge
    Department of Biomaterials, College of Dental Science, University Medical Center Nijmegen, Nijmegen, The Netherlands
    Tissue Eng 8:615-26. 2002
    ..Based on our results, we conclude that the studied materials are capable of influencing the expression of integrins by RBM cells cultured on relevant implant materials...
  31. ncbi request reprint Ligand-conjugated quantum dots monitor antigen uptake and processing by dendritic cells
    Alessandra Cambi
    Department of Molecular Biology, Max Planck Institute for Biophysical Chemistry, Gottingen, Germany
    Nano Lett 7:970-7. 2007
    ..The antigen-coated QDs specific uptake and persistence in live DCs open the possibility for tracking antigen-presenting cells in vivo...
  32. ncbi request reprint Binding of the adhesion and pathogen receptor DC-SIGN by monocytes is regulated by the density of Lewis X molecules
    Karlijn Gijzen
    Department of Tumor Immunology, Nijmegen Centre for Molecular Life Sciences, Radboud University Nijmegen Medical Centre, PO Box 9101, 6500 HB Nijmegen, The Netherlands
    Mol Immunol 44:2481-6. 2007
    ..Regulating the number of ligands endows monocytes with the capacity to modulate binding to DC-SIGN. This may result in a bi-directional cross-talk between DC and monocytes, to modulate innate and/or adaptive immune responses...
  33. ncbi request reprint Sensitivity of magnetic resonance imaging of dendritic cells for in vivo tracking of cellular cancer vaccines
    Pauline Verdijk
    Department of Tumorimmunology, Nijmegen Centre for Molecular Life Science, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Int J Cancer 120:978-84. 2007
    ....
  34. ncbi request reprint Relevance of DC-SIGN in DC-induced T cell proliferation
    Karlijn Gijzen
    Department of Tumor Immunology, NCMLS 278, Radboud University Nijmegen Medical Centre, Geert Grooteplein 26 28, 6525 GA Nijmegen, The Netherlands
    J Leukoc Biol 81:729-40. 2007
    ..This study indicates an initial and transient role for DC-SIGN in T cell proliferation, which becomes apparent when T cell proliferation is low and when the percentage of DC-SIGN binding PBL is high...
  35. ncbi request reprint Long-term engagement of CD6 and ALCAM is essential for T-cell proliferation induced by dendritic cells
    Aukje W Zimmerman
    Department of Tumor Immunology, Nijmegen Centre for Molecular Life Sciences, The Netherlands
    Blood 107:3212-20. 2006
    ....
  36. ncbi request reprint Phenotypic and functional characterization of mature dendritic cells from pediatric cancer patients
    Joannes F M Jacobs
    Department of Pediatric Hemato Oncology, Nijmegen Centre of Molecular Life Sciences, Radboud University Medical Centre Nijmegen, Nijmegen, The Netherlands
    Pediatr Blood Cancer 49:924-7. 2007
    ..We studied whether sufficient amounts of mature monocyte-derived DCs can be cultured from peripheral blood of pediatric cancer patients...
  37. doi request reprint Human and murine model cell lines for dendritic cell biology evaluated
    Suzanne F G van Helden
    Department of Tumor Immunology, Nijmegen Centre for Molecular Life Sciences, Radboud University Nijmegen Medical Centre, Geert Grooteplein Zuid 28, PO Box 9101, 6500 HB Nijmegen, The Netherlands
    Immunol Lett 117:191-7. 2008
    ..We conclude that, although none of these cell lines fully recapitulates all cell biological or immunological features of primary DCs, some of these cell lines provide valuable tools to study specific aspects of DC biology...
  38. ncbi request reprint Nanoscale organization of the pathogen receptor DC-SIGN mapped by single-molecule high-resolution fluorescence microscopy
    Bärbel I de Bakker
    Applied Optics Group, Faculty of Science and Technology, MESA Institute for Nanotechnology, University of Twente, The Netherlands
    Chemphyschem 8:1473-80. 2007
    ..Our data also illustrate the potential of NSOM as an ultrasensitive, high-resolution technique to probe nanometer-scale organization of molecules on the cell membrane...
  39. ncbi request reprint In vivo targeting of DC-SIGN-positive antigen-presenting cells in a nonhuman primate model
    Candida F Pereira
    Department of Tumor Immunology, Nijmegen Centre for Molecular Life Sciences, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    J Immunother 30:705-14. 2007
    ..In conclusion, this is the first study that shows specific targeting of APCs in vivo by using antibodies directed against DC-SIGN...
  40. doi request reprint Targeting DCIR on human plasmacytoid dendritic cells results in antigen presentation and inhibits IFN-alpha production
    Friederike Meyer-Wentrup
    Department of Tumor Immunology, Radboud University Nijmegen Medical Centre and Nijmegen Centre for Molecular Life Sciences, Nijmegen, The Netherlands
    Blood 111:4245-53. 2008
    ..Collectively, the data show that targeting of DCIR can modulate human pDC function and may be applied in disease prevention and treatment...
  41. pmc Dendritic cell interaction with Candida albicans critically depends on N-linked mannan
    Alessandra Cambi
    Department of Tumor Immunology, Nijmegen Centre for Molecular Life Sciences, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    J Biol Chem 283:20590-9. 2008
    ..Better insight in the carbohydrate recognition profile of C-type lectins will ultimately provide relevant information for the development of new drugs targeting specific fungal cell wall antigens...
  42. ncbi request reprint Monocyte cell surface glycosaminoglycans positively modulate IL-4-induced differentiation toward dendritic cells
    Els den Dekker
    Department of Tumor Immunology, Nijmegen Centre for Molecular Life Sciences, Nijmegen, The Netherlands
    J Immunol 180:3680-8. 2008
    ..Together, these data demonstrate that monocyte cell surface chondroitin sulfates play an important role in the IL-4-driven differentiation of monocytes into DCs...
  43. doi request reprint Interaction of acute lymphopblastic leukemia cells with C-type lectins DC-SIGN and L-SIGN
    Karlijn Gijzen
    Department of Tumor Immunology, Nijmegen Centre for Molecular Life Sciences, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Exp Hematol 36:860-70. 2008
    ..Additional studies are necessary to ascertain the possible role of these results in terms of disease pathogenesis and their potential as target to eradicate leukemic cells...
  44. ncbi request reprint No advantage of cell-penetrating peptides over receptor-specific antibodies in targeting antigen to human dendritic cells for cross-presentation
    Paul J Tacken
    Department of Tumor Immunology, Nijmegen Centre for Molecular Life Sciences, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    J Immunol 180:7687-96. 2008
    ..Given the specificity with which Abs recognize their targets, this favors the use of DC receptor-specific Abs for in vivo vaccination strategies...
  45. ncbi request reprint Identification of different binding sites in the dendritic cell-specific receptor DC-SIGN for intercellular adhesion molecule 3 and HIV-1
    Teunis B H Geijtenbeek
    Department of Molecular Cell Biology, Vrije University Medical Center Amsterdam, The Netherlands
    J Biol Chem 277:11314-20. 2002
    ..This study provides a basis for the design of drugs that inhibit or alter interactions of DC-SIGN with gp120 but not with ICAM-3 or vice versa and that have a therapeutic value in immunological diseases and/or HIV-1 infections...
  46. ncbi request reprint The dendritic cell-specific adhesion receptor DC-SIGN internalizes antigen for presentation to T cells
    Anneke Engering
    Department of Molecular Cell Biology, Vrye Universiteit Medical Center, Van der Boechorststraat 7, 1081 BT Amsterdam, The Netherlands
    J Immunol 168:2118-26. 2002
    ..These data point to a novel function of the adhesion receptor DC-SIGN as an efficient DC-specific Ag receptor that can be used as a target to induce viral and antitumor immunity...
  47. ncbi request reprint Effective induction of naive and recall T-cell responses by targeting antigen to human dendritic cells via a humanized anti-DC-SIGN antibody
    Paul J Tacken
    Department of Tumor Immunology, Nijmegen Centre for Molecular Life Sciences, Radboud University Nijmegen Medical Centre, Nijmegen, PO Box 9101, 6500 HB Nijmegen, The Netherlands
    Blood 106:1278-85. 2005
    ..This identifies DC-SIGN as a promising target molecule for DC-based vaccination strategies...
  48. ncbi request reprint Dual function of C-type lectin-like receptors in the immune system
    Alessandra Cambi
    Department of Tumor Immunology, Nijmegen Center for Molecular Life Sciences, NCMLS 187 TIL, Postbox 9101, 6500HB Nijmegen, The Netherlands
    Curr Opin Cell Biol 15:539-46. 2003
    ..Although major differences in the cytoplasmic domains of these receptors might predict their function, recent findings show that differences in glycosylation of ligands can dramatically alter C-type lectin-like receptor usage...
  49. ncbi request reprint Expression of the dendritic cell-associated C-type lectin DC-SIGN by inflammatory matrix metalloproteinase-producing macrophages in rheumatoid arthritis synovium and interaction with intercellular adhesion molecule 3-positive T cells
    Peter L E M van Lent
    Department of Rheumatology, University Medical Centre Nijmegen, Nijmegen, The Netherlands
    Arthritis Rheum 48:360-9. 2003
    ....
  50. pmc Microdomains of the C-type lectin DC-SIGN are portals for virus entry into dendritic cells
    Alessandra Cambi
    Dept of Tumor Immunology, Nijmegen Center for Molecular Life Sciences, University Medical Center Nijmegen, P O Box 9101, 6500 HB Nijmegen, Netherlands
    J Cell Biol 164:145-55. 2004
    ....
  51. ncbi request reprint The C-type lectin DC-SIGN (CD209) is an antigen-uptake receptor for Candida albicans on dendritic cells
    Alessandra Cambi
    Department of Tumor Immunology, Nijmegen Center for Molecular Life Sciences, University Medical Center Nijmegen, Nijmegen, The Netherlands
    Eur J Immunol 33:532-8. 2003
    ..albicans receptor expressed by DC. Together, these results demonstrate that DC-SIGN is an exquisite pathogen-uptake receptor that captures not only viruses but also fungi...
  52. ncbi request reprint Ceramic hydroxyapatite coating on titanium implants drives selective bone marrow stromal cell adhesion
    Ruurd Torensma
    Department of Tumor Immunology, UMC Nijmegen, Nijmegen, The Netherlands
    Clin Oral Implants Res 14:569-77. 2003
    ..These results demonstrate that hydroxyapatite ceramics are selective in cell recruitment from the bone marrow, explaining the differences found in vivo for these coatings compared with titanium...
  53. doi request reprint PGE2-mediated podosome loss in dendritic cells is dependent on actomyosin contraction downstream of the RhoA-Rho-kinase axis
    Suzanne F G van Helden
    Department of Tumor Immunology, Nijmegen Centre for Molecular Life Sciences, Radboud University Nijmegen Medical Centre, PO Box 9101, 6500 HB Nijmegen, The Netherlands
    J Cell Sci 121:1096-106. 2008
    ....
  54. pmc Maturation of monocyte-derived dendritic cells with Toll-like receptor 3 and 7/8 ligands combined with prostaglandin E2 results in high interleukin-12 production and cell migration
    A C Inge Boullart
    Department of Tumor Immunology, Nijmegen Centre for Molecular Life Science, Radboud University Nijmegen Medical Centre, P O Box 9101, 6500 HB Nijmegen, The Netherlands
    Cancer Immunol Immunother 57:1589-97. 2008
    ..We propose a novel clinical grade maturation protocol in which TLR ligands poly(I:C) and R848 are combined with PGE2 to generate DC with both high migratory capacity and IL-12p70 production upon T cell encounter...
  55. ncbi request reprint An automated multi well cell track system to study leukocyte migration
    Daniëlle J E B Krooshoop
    Department of Tumor Immunology, NCMLS, Nijmegen, The Netherlands
    J Immunol Methods 280:89-102. 2003
    ..The analysis of multiple wells in parallel makes this set-up appropriate in high throughput screening in which multiple components are simultaneously tested for their effect on cell migration...
  56. ncbi request reprint Maturation of dendritic cells is a prerequisite for inducing immune responses in advanced melanoma patients
    I Jolanda M de Vries
    Department of Tumor Immunology, University Medical Center St Radboud Nijmegen and Nijmegen Center for Molecular Life Sciences, Nijmegen, The Netherlands
    Clin Cancer Res 9:5091-100. 2003
    ..We have investigated the capacity of immature and mature monocyte-derived DCs pulsed with melanoma-associated peptides (gp100 and tyrosinase) to induce a primary cytotoxic T-lymphocyte response in vivo...
  57. ncbi request reprint Dendritic-cell immunotherapy: from ex vivo loading to in vivo targeting
    Paul J Tacken
    Nijmegen Centre for Molecular Life Sciences, Radboud University Nijmegen Medical Centre, Tumour Immunology, Postbox 9101, Nijmegen, 6500HB, Netherlands
    Nat Rev Immunol 7:790-802. 2007
    ..Here, we discuss how direct targeting of antigens to DC surface receptors in vivo might replace laborious and expensive ex vivo culturing, and facilitate large-scale application of DC-based vaccination therapies...
  58. ncbi request reprint Analysis of dendritic cell trafficking using EGFP-transgenic mice
    Andreas A O Eggert
    Tumor Immunology Laboratory, University Medical Center Nijmegen St Radboud, P O Box 9101, 6500 HB Nijmegen, The Netherlands
    Immunol Lett 89:17-24. 2003
    ..c. injection. Subsequent quantitative, phenotypical and ultrastuctural analysis demonstrate that DC generated from EGFP-transgenic mice are well suited to study the migratory behavior, distribution and phenotype of DC in vivo...
  59. ncbi request reprint Different faces of the heme-heme oxygenase system in inflammation
    Frank A D T G Wagener
    Department of Tumor Immunology, University Medical Center Nijmegen, P O Box 9101, 6500 HB Nijmegen, The Netherlands
    Pharmacol Rev 55:551-71. 2003
    ..Pre-induction of HO activity has been demonstrated to ameliorate inflammation and mediate potent resistance to oxidative injury. A better understanding of the complex heme-heme..
  60. ncbi request reprint Immunomonitoring tumor-specific T cells in delayed-type hypersensitivity skin biopsies after dendritic cell vaccination correlates with clinical outcome
    I Jolanda M de Vries
    Department of Tumor Immunology, Radbond University Nijmegen Medical Center, Geert Grooteplein 26 28, 6500 HB Nijmegen, Netherlands
    J Clin Oncol 23:5779-87. 2005
    ..In this study, we investigated the predictive value of the presence or absence of antigen-specific T cells in biopsies from delayed-type hypersensitivity (DTH) sites...
  61. doi request reprint In vivo colocalization of antigen and CpG [corrected] within dendritic cells is associated with the efficacy of cancer immunotherapy
    Stefan Nierkens
    Department of Tumor Immunology, Nijmegen Centre for Molecular Life Sciences, Radboud University Medical Centre, Nijmegen, The Netherlands
    Cancer Res 68:5390-6. 2008
    ..These data might aid in the design of future immunotherapeutic strategies for cancer patients...
  62. ncbi request reprint Activation of human plasmacytoid dendritic cells by TLR9 impairs Fc gammaRII-mediated uptake of immune complexes and presentation by MHC class II
    Daniel Benitez-Ribas
    Department of Tumor Immunology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    J Immunol 181:5219-24. 2008
    ..We hypothesize that pDC, once activated via TLR9-ligands reaching the late endosomes, can only present initially sampled Ags and thus are protected from uptake and processing of additional potential self-Ags...
  63. ncbi request reprint Peptide fine specificity of anti-glycoprotein 100 CTL is preserved following transfer of engineered TCR alpha beta genes into primary human T lymphocytes
    Niels Schaft
    Clinical and Tumor Immunology, Department of Medical Oncology, Erasmus Medical Center Daniel den Hoed, Groene Hilledijk 301, 3075 EA Rotterdam, The Netherlands
    J Immunol 170:2186-94. 2003
    ....
  64. ncbi request reprint Maximizing dendritic cell migration in cancer immunotherapy
    Pauline Verdijk
    Radboud University Nijmegen Medical Centre, Department of Tumor Immunology, Nijmegen Centre for Molecular Life Sciences, Geert Grooteplein 28, Nijmegen, The Netherlands
    Expert Opin Biol Ther 8:865-74. 2008
    ..The success of dendritic cell (DC)-based immunotherapy in inducing cellular immunity against tumors is highly dependent on accurate delivery and trafficking of the DC to T-cell-rich areas of secondary lymphoid tissues...
  65. ncbi request reprint Effective migration of antigen-pulsed dendritic cells to lymph nodes in melanoma patients is determined by their maturation state
    I Jolanda M de Vries
    Department of Tumor Immunology, University Medical Center Nijmegen, 6500 HB Nijmegen, The Netherlands
    Cancer Res 63:12-7. 2003
    ..Our present findings demonstrate that the ability of dendritic cells to mount a proper immune response correlates with their ability to migrate both in vitro and in vivo...
  66. ncbi request reprint Phenotypical and functional characterization of clinical grade dendritic cells
    I Jolanda M de Vries
    Department of Tumot Immunology, University Medical Center St Radboud, Nijmegen, The Netherlands
    J Immunother 25:429-38. 2002
    ..In conclusion, a culture procedure was established to generate large numbers of monocyte-derived immature and mature DC that retain their morphologic, phenotypic, and functional characteristics in vitro and can be visualized in situ...
  67. ncbi request reprint Distinct kinetic and mechanical properties govern ALCAM-mediated interactions as shown by single-molecule force spectroscopy
    Joost Te Riet
    Department of Tumour Immunology 278, Nijmegen Centre for Molecular Life Sciences NCMLS, Radboud University Nijmegen Medical Centre, PO Box 9101, 6500HB Nijmegen, The Netherlands
    J Cell Sci 120:3965-76. 2007
    ....
  68. ncbi request reprint Presence and localization of T-cell subsets in relation to melanocyte differentiation antigen expression and tumour regression as assessed by immunohistochemistry and molecular analysis of microdissected T cells
    Monique R Bernsen
    Department of Pathology, University Medical Center Nijmegen, Nijmegen, The Netherlands
    J Pathol 202:70-9. 2004
    ..Full understanding of these processes can only be achieved by performing more dynamic analyses of the local host-tumour interactions...
  69. pmc Organization of the integrin LFA-1 in nanoclusters regulates its activity
    Alessandra Cambi
    Department of Tumor Immunology, Nijmegen Centre for Molecular Life Sciences, Radboud University Nijmegen Medical Centre, 6500 HB Nijmegen, The Netherlands
    Mol Biol Cell 17:4270-81. 2006
    ....
  70. ncbi request reprint Synergy between in situ cryoablation and TLR9 stimulation results in a highly effective in vivo dendritic cell vaccine
    Martijn H M G M den Brok
    Department of Tumor Immunology, Nijmegen Center for Molecular Life Sciences, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands
    Cancer Res 66:7285-92. 2006
    ..Therefore, in situ tumor destruction in combination with CpG-oligodeoxynucleotide administration creates a unique "in situ DC vaccine" that is readily applicable in the clinic...
  71. ncbi request reprint A critical role for prostaglandin E2 in podosome dissolution and induction of high-speed migration during dendritic cell maturation
    Suzanne F G van Helden
    Department of Tumor Immunology, Nijmegen Centre for Molecular Life Sciences, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    J Immunol 177:1567-74. 2006
    ..Together, these results show that maturation-induced podosome dissolution and loss of alpha(5)beta(1) integrin activity allow human DCs to undergo the transition from an adhesive to a highly migratory phenotype...
  72. pmc Plasmacytoid dendritic cells of melanoma patients present exogenous proteins to CD4+ T cells after Fc gamma RII-mediated uptake
    Daniel Benitez-Ribas
    Department of Tumor Immunology, Radboud University Nijmegen Medical Centre and Nijmegen Centre for Molecular Life Sciences, 6500 HB Nijmegen, Netherlands
    J Exp Med 203:1629-35. 2006
    ..Antigen presentation by pDCs may thus modulate the strength and quality of the secondary phase of an immune response...
  73. ncbi request reprint Development of 111In-labeled tumor-associated antigen peptides for monitoring dendritic-cell-based vaccination
    Peter Laverman
    Department of Nuclear Medicine, Radboud University Nijmegen Medical Centre, PO Box 9101, 6500 HB Nijmegen, The Netherlands
    Nucl Med Biol 33:453-8. 2006
    ..However, little is known about the fate of the MHC-peptide complex after injection of these peptide-loaded DC. The aim of the present study was to develop radiolabeled, tumor-derived peptides to monitor their binding to MHC Class I...
  74. ncbi request reprint Magnetic resonance tracking of dendritic cells in melanoma patients for monitoring of cellular therapy
    I Jolanda M de Vries
    Department of Tumor Immunology, Radboud University Nijmegen Medical Center and Nijmegen Center for Molecular Life Sciences, Geert Grooteplein 28, 6500 HB Nijmegen, The Netherlands
    Nat Biotechnol 23:1407-13. 2005
    ..MRI cell tracking using iron oxides appears clinically safe and well suited to monitor cellular therapy in humans...
  75. ncbi request reprint Dendritic cells: tools and targets for antitumor vaccination
    Martijn H M G M den Brok
    Department of Tumor Immunology, Nijmegen Centre for Molecular Life Sciences, Radboud University Medical Centre, 6500 HB Nijmegen, The Netherlands
    Expert Rev Vaccines 4:699-710. 2005
    ....
  76. ncbi request reprint Elevated CXCL16 expression by synovial macrophages recruits memory T cells into rheumatoid joints
    Robbert van der Voort
    Nijmegen Center for Molecular Life Sciences, University Medical Center St Radboud, Nijmegen, The Netherlands
    Arthritis Rheum 52:1381-91. 2005
    ..This study was undertaken to examine the presence of CXCR6+ T cells and of CXCL16, the only ligand for CXCR6, in the joints of patients with rheumatoid arthritis (RA)...
  77. ncbi request reprint C-type lectins on dendritic cells and their interaction with pathogen-derived and endogenous glycoconjugates
    Karlijn Gijzen
    Department of Tumor Immunology, Nijmegen Centre for Molecular Life Sciences, Radboud University Nijmegen Medical Centre, The Netherlands
    Curr Protein Pept Sci 7:283-94. 2006
    ..When CLRs bind endogenous glycosylated ligands they mediate several processes like cell-cell adhesion and clearance of aberrant cells like tumor cells or apoptotic cells...
  78. ncbi request reprint Targeting antigens to dendritic cells in vivo
    Paul J Tacken
    Department of Tumor Immunology, Nijmegen Centre for Molecular Life Sciences, Radboud University Nijmegen Medical Centre, Nijmegen, 6500 HB Nijmegen, The Netherlands
    Immunobiology 211:599-608. 2006
    ..The present review focuses on the various antigen delivery systems that are currently in use and the DC surface receptors they target...
  79. ncbi request reprint Cytoskeletal restraints regulate homotypic ALCAM-mediated adhesion through PKCalpha independently of Rho-like GTPases
    Aukje W Zimmerman
    Department of Tumor Immunology, University Medical Center St Radboud, Nijmegen, The Netherlands
    J Cell Sci 117:2841-52. 2004
    ..We conclude that PKCalpha plays a dominant role in cytoskeleton-dependent avidity modulation of ALCAM...
  80. ncbi request reprint Novel monoclonal antibodies detect elevated levels of the chemokine CCL18/DC-CK1 in serum and body fluids in pathological conditions
    Robbert van der Voort
    Department of Tumor Immunology, Nijmegen Center for Molecular Life Scences, University Medical Center St Radboud, Nijmegen, P O Box 9101, 6500 HB Nijmegen, The Netherlands
    J Leukoc Biol 77:739-47. 2005
    ..CCL18/DC-CK1 may therefore function as an agonist (for naive T and B cells) and as an antagonist for CCR3-expressing leukocytes such as eosinophils...
  81. ncbi request reprint Dendritic cell immunotherapy: mapping the way
    Carl G Figdor
    Department of Tumor Immunology, Nijmegen Center for Molecular Life Sciences, University Medical Center Nijmegen, PO Box 9101, 6500HB Nijmegen, The Netherlands
    Nat Med 10:475-80. 2004
    ..Although early clinical trials indicate that DC vaccines can induce immune responses in some cancer patients, careful study design and use of standardized clinical and immunological criteria are needed...
  82. ncbi request reprint In situ tumor ablation creates an antigen source for the generation of antitumor immunity
    Martijn H M G M den Brok
    Department of Tumor Immunology, Nijmegen Center for Molecular Life Sciences, Nijmegen, The Netherlands
    Cancer Res 64:4024-9. 2004
    ..These results illustrate that in situ tumor destruction can provide a useful antigen source for the induction of antitumor immunity, provided that additional immunostimulatory signals are coadministered...
  83. ncbi request reprint Phenotypical and functional characterization of clinical-grade dendritic cells
    I Jolanda M de Vries
    Department of Tumor Immunology, Nijmegen Center for Molecular Life Sciences, University Medical Center Nijmegen, Nijmegen, The Netherlands
    Methods Mol Med 109:113-26. 2005
    ..In this chapter we discuss the usefulness of standardized clinical and immunological criteria and the need for careful study design to further optimize the use of dendritic cells and to unequivocally prove their efficacy...
  84. ncbi request reprint The dendritic cell-derived protein DC-STAMP is highly conserved and localizes to the endoplasmic reticulum
    Dagmar Eleveld-Trancikova
    NCMLS 187 TIL University Medical Center, Postbox 9101, 6500 HB Nijmegen, The Netherlands
    J Leukoc Biol 77:337-43. 2005
    ..These data imply that DC-STAMP may exert its effect in the ER...
  85. ncbi request reprint Dectin-1 interaction with tetraspanin CD37 inhibits IL-6 production
    Friederike Meyer-Wentrup
    Department of Tumor Immunology, Nijmegen Centre for Molecular Life Sciences, University Medical Centre, Nijmegen, The Netherlands
    J Immunol 178:154-62. 2007
    ..Taken together, these findings show that tetraspanin CD37 is important for dectin-1 stabilization in APC membranes and controls dectin-1-mediated IL-6 production...
  86. ncbi request reprint Migration of dendritic cell based cancer vaccines: in vivo veritas?
    Gosse J Adema
    Department of Tumor Immunology, Nijmegen Center for Molecular Life Sciences, and Medical Oncology, Nijmegen, The Netherlands
    Curr Opin Immunol 17:170-4. 2005
    ..Recent advances have been made in understanding DC migration in the context of DC-based vaccines...
  87. ncbi request reprint "Sweet talk": closing in on C type lectin signaling
    Friederike Meyer-Wentrup
    Department of Tumor Immunology, Nijmegen Centre of Molecular Life Sciences, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Immunity 22:399-400. 2005
    ....
  88. ncbi request reprint Levels of complexity in pathogen recognition by C-type lectins
    Alessandra Cambi
    Department of Tumor Immunology, Nijmegen Centre for Molecular Life Sciences, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Curr Opin Immunol 17:345-51. 2005
    ..Crosstalk between these receptors results in a network of multimolecular complexes, adding a further level of complexity in pathogen recognition...