Research Topics
Genomes and GenesSpecies | Sarah DurstonSummaryAffiliation: University Medical Center Utrecht Country: The Netherlands Publications
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Detail Information
Publications
Anatomical MRI of the developing human brain: what have we learned?S Durston
Department of Child and Adolescent Psychiatry, University Medical Center Utrecht, The Netherlands
J Am Acad Child Adolesc Psychiatry 40:1012-20. 2001..To critically review and integrate the existing literature on magnetic resonance imaging (MRI) studies of the normally developing brain in childhood and adolescence and discuss the implications for clinical MRI studies...- A shift from diffuse to focal cortical activity with development: the authors' replySarah Durston
Sackler Institute for Developmental Psychobiology, Weill Medical College of Cornell University, New York, USA
Dev Sci 9:18-20. 2006 - A shift from diffuse to focal cortical activity with developmentSarah Durston
Sackler Institute for Developmental Psychobiology, Weill Medical College of Cornell University, New York, USA
Dev Sci 9:1-8. 2006..Our longitudinal findings, relative to our cross-sectional ones, show attenuated activation in dorsolateral prefrontal cortical areas, paralleled by increased focal activation in ventral prefrontal regions related to task performance... - What have we learned about cognitive development from neuroimaging?Sarah Durston
Sackler Institute for Developmental Psychobiology, Weill Medical College of Cornell University, New York, NY 10021, USA
Neuropsychologia 44:2149-57. 2006..Finally, the relevance of normative studies for understanding neural and cognitive changes in developmental disorders is discussed... - Activation in ventral prefrontal cortex is sensitive to genetic vulnerability for attention-deficit hyperactivity disorderSarah Durston
Rudolf Magnus Institute of Neuroscience, Department of Child and Adolescent Psychiatry, University Medical Center Utrecht, 3584 CX Utrecht, The Netherlands
Biol Psychiatry 60:1062-70. 2006..Neuroimaging measures may serve as an intermediate phenotype in genetic studies of ADHD, as they are putatively more closely linked to gene expression than a clinical diagnosis... - Differential effects of DRD4 and DAT1 genotype on fronto-striatal gray matter volumes in a sample of subjects with attention deficit hyperactivity disorder, their unaffected siblings, and controlsS Durston
Department of Child and Adolescent Psychiatry, Rudolf Magnus Institute for Neuroscience, University Medical Center Utrecht, Utrecht, The Netherlands
Mol Psychiatry 10:678-85. 2005.... - Magnetic resonance imaging of boys with attention-deficit/hyperactivity disorder and their unaffected siblingsSarah Durston
Rudolf Magnus Institute of Neuroscience, Department of Psychiatry, University Medical Center Utrecht, Utrecht, The Netherlands
J Am Acad Child Adolesc Psychiatry 43:332-40. 2004..To study the influence of increased familial risk for attention-deficit/hyperactivity disorder (ADHD) on brain morphology... - Parametric manipulation of conflict and response competition using rapid mixed-trial event-related fMRIS Durston
Sackler Institute for Developmental Psychobiology, Weill Medical College of Cornell University, New York, NY 10021, USA
Neuroimage 20:2135-41. 2003.... - A review of the biological bases of ADHD: what have we learned from imaging studies?Sarah Durston
Department of Child and Adolescent Psychiatry, University Medical Center Utrecht, The Netherlands
Ment Retard Dev Disabil Res Rev 9:184-95. 2003..The future impact of new MR imaging methodologies on the field is discussed... 
Familial vulnerability to ADHD affects activity in the cerebellum in addition to the prefrontal systemsMartijn J Mulder
Department of Child and Adolescent Psychiatry, Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, Heidelberglaan 100, 3584 CX Utrecht, The Netherlands
J Am Acad Child Adolesc Psychiatry 47:68-75. 2008..In this study, we investigated whether cerebellar systems are sensitive to familial risk for ADHD in addition to frontostriatal circuitry...- Changes in the developmental trajectories of striatum in autismMarieke Langen
Department of Child and Adolescent Psychiatry, Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, Utrecht, The Netherlands
Biol Psychiatry 66:327-33. 2009..The objective was to examine brain development in a homogeneous sample of subjects with high-functioning autism... 
Differential brain development with low and high IQ in attention-deficit/hyperactivity disorderPatrick de Zeeuw
Neuroimaging Lab, Department of Child and Adolescent Psychiatry, Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, Utrecht, The Netherlands
PLoS ONE 7:e35770. 2012....- Neural and behavioral correlates of expectancy violations in attention-deficit hyperactivity disorderSarah Durston
Sackler Institute for Developmental Psychobiology, Weill Medical College of Cornell University, New York, USA
J Child Psychol Psychiatry 48:881-9. 2007..Therefore, we hypothesized that the ability to predict the occurrence of frequent events would be compromised in ADHD, as well as the ability to adapt behavior when expectancy was violated... - Caudate nucleus is enlarged in high-functioning medication-naive subjects with autismMarieke Langen
Department of Child and Adolescent Psychiatry, Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, Utrecht, The Netherlands
Biol Psychiatry 62:262-6. 2007..Earlier studies investigating basal ganglia in autism have included subjects on neuroleptics known to affect basal ganglia volumes. Therefore, we investigated these structures in medication-naive subjects with autism... - No evidence for structural brain changes in young adolescents at ultra high risk for psychosisTim B Ziermans
Department of Child and Adolescent Psychiatry, Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, Heidelberglaan 100, Utrecht, The Netherlands
Schizophr Res 112:1-6. 2009..However, the timing of these changes has not been established. We investigated structural brain changes in a sample of young adolescents (12-18 years) at ultra high-risk for psychosis (UHR)... - No differences in MR-based volumetry between 2- and 7-year-old children with autism spectrum disorder and developmental delayMijke Zeegers
Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, Utrecht, The Netherlands
Brain Dev 31:725-30. 2009..In addition, to study the association of intellectual functioning on brain volumes in children with ASD or developmental delay... - Dopamine transporter genotype conveys familial risk of attention-deficit/hyperactivity disorder through striatal activationSarah Durston
Department of Child and Adolescent Psychiatry, Rudolf Magnus Institute for Neurosciences, Neuroimaging Lab, HP A 01 468, University Medical Center Utrecht, Heidelberglaan 100, 3584 CX Utrecht, The Netherlands
J Am Acad Child Adolesc Psychiatry 47:61-7. 2008..We hypothesized that the DAT1 genotype would affect brain activation patterns in a manner similar to that of stimulant medication, with the lesser expressing allele mirroring its effects... - Differentiating frontostriatal and fronto-cerebellar circuits in attention-deficit/hyperactivity disorderSarah Durston
Neuroimaging Laboratory, Department of Child and Adolescent Psychiatry, Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, Utrecht, The Netherlands
Biol Psychiatry 69:1178-84. 2011..This could be useful as a template for investigating the neurobiology of ADHD and, ultimately, clinically... - Functional connectivity between cognitive control regions is sensitive to familial risk for ADHDMartijn J Mulder
Rudolf Magnus Institute of Neuroscience, Department of Child and Adolescent Psychiatry, Neuroimaging Lab, University Medical Center Utrecht, Utrecht, The Netherlands
Hum Brain Mapp 32:1511-8. 2011..Results suggest that changes in connectivity associated with cognitive control may be suitable as an intermediate phenotype for future studies... - The neurobiology of repetitive behavior: of mice…Marieke Langen
Department of Child and Adolescent Psychiatry, Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, The Netherlands
Neurosci Biobehav Rev 35:345-55. 2011..Although the exact nature of these imbalances are not yet fully understood, synthesizing the literature in this area provides a framework for studying the neurobiological systems involved in repetitive behavior... - Evidence of developmental differences in implicit sequence learning: an fMRI study of children and adultsKathleen M Thomas
Weill Medical College of Cornell University, USA
J Cogn Neurosci 16:1339-51. 2004..These results challenge the idea of developmental invariance in implicit learning and instead support a view of parallel developments in implicit and explicit learning systems... - The neurobiology of repetitive behavior: …and menMarieke Langen
Department of Child and Adolescent Psychiatry, Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, The Netherlands
Neurosci Biobehav Rev 35:356-65. 2011..These findings suggest a model for classifying repetitive behavior by its neuroanatomical correlates... - Decreased frontostriatal microstructural organization in attention deficit/hyperactivity disorderPatrick de Zeeuw
Neuroimaging Lab, Department of Child and Adolescent Psychiatry, Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, The Netherlands
Hum Brain Mapp 33:1941-51. 2012..A correlation with attention problems for controls suggests that frontostriatal organization is relevant to ADHD-related behaviors... - Increased gray-matter volume in medication-naive high-functioning children with autism spectrum disorderSaskia J M C Palmen
Department of Child and Adolescent Psychiatry, Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, Utrecht, The Netherlands
Psychol Med 35:561-70. 2005.... - Basic impairments in regulating the speed-accuracy tradeoff predict symptoms of attention-deficit/hyperactivity disorderMartijn J Mulder
Rudolf Magnus Institute of Neuroscience, Department of Child and Adolescent Psychiatry, University Medical Center Utrecht, The Netherlands
Biol Psychiatry 68:1114-9. 2010..Theoretical accounts of ADHD have often focused on higher-order cognitive processes and typically assume that basic processes are unaffected. It is an open question whether this is indeed the case... - Progressive structural brain changes during development of psychosisTim B Ziermans
Department of Child and Adolescent Psychiatry, Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, The Netherlands
Schizophr Bull 38:519-30. 2012..Ultra-high risk (UHR) for psychosis has been associated with widespread structural brain changes in young adults. The onset of these changes and their subsequent progression over time are not well understood... - Imaging genetics in ADHD: a focus on cognitive controlSarah Durston
Neuroimaging Laboratory, Rudolf Magnus Institute of Neuroscience, Department of Child and Adolescent Psychiatry, University Medical Center Utrecht, Heidelberglaan 100, Utrecht, The Netherlands
Neurosci Biobehav Rev 33:674-89. 2009..Other avenues of investigation are suggested by a combination of data- and theory-driven approaches in both genetics and neuroimaging... - Imaging the developing brain: what have we learned about cognitive development?B J Casey
Sackler Institute for Developmental Psychobiology, Weill Medical College of Cornell University, 1300 York Avenue, Box 140, New York, NY 10021, USA
Trends Cogn Sci 9:104-10. 2005..Brain regions associated with more basic functions such as sensory and motor processes mature first, followed by association areas involved in top-down control of behavior... - No evidence for preferential involvement of medial temporal lobe structures in high-functioning autismSaskia J M C Palmen
Rudolf Magnus Institute of Neuroscience, Department of Child, University Medical Center Utrecht, Utrecht, The Netherlands
Psychol Med 36:827-34. 2006..Here, we investigate amygdala and hippocampus volumes in medication-naive subjects with high-functioning autism... - Imaging genetics in ADHDSarah Durston
Department of Child and Adolescent Psychiatry, Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht HP A 01 468, Heidelberglaan 100, 3584 CX Utrecht, The Netherlands
Neuroimage 53:832-8. 2010.... - Deficits in Cognitive Control, Timing and Reward Sensitivity Appear to be Dissociable in ADHDPatrick de Zeeuw
Neuroimaging Lab, Developmental Disorders Unit, Department of Psychiatry, Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, Utrecht, The Netherlands
PLoS ONE 7:e51416. 2012..These results support a neurobiological framework of separate biological pathways to ADHD with separable cognitive deficits... - Differential patterns of striatal activation in young children with and without ADHDSarah Durston
Sackler Institute for Developmental Psychobiology, Weill Medical College of Cornell University, New York, New York 10021, USA
Biol Psychiatry 53:871-8. 2003..ADHD children show a slightly different cognitive profile at 6 to 10 years of age that is paralleled by a relative lack of or delay in the maturation of ventral frontostriatal circuitry... - Converging methods in studying attention-deficit/hyperactivity disorder: what can we learn from neuroimaging and genetics?Sarah Durston
Rudolf Magnus Institute of Neuroscience, Department of Child and Adolescent Psychiatry, Neuroimaging Lab, HP A 01 468, University Medical Center Utrecht, Heidelberglaan 100, 3584 CX Utrecht, The Netherlands
Dev Psychopathol 20:1133-43. 2008.... - New potential leads in the biology and treatment of attention deficit-hyperactivity disorderB J Casey
Sackler Institute for Developmental Psychobiology, Weill Medical College of Cornell University, New York, New York 10021, USA
Curr Opin Neurol 20:119-24. 2007..This review highlights recent neuroimaging and genetic studies of attention deficit-hyperactivity disorder that may inform biologically targeted interventions and treatments... - Radiological findings in autistic and developmentally delayed childrenMijke Zeegers
Rudolf Magnus Institute of Neuroscience, Department of Child and Adolescent Psychiatry, University Medical Center Utrecht, The Netherlands
Brain Dev 28:495-9. 2006.... - From behavior to cognition to the brain and back: what have we learned from functional imaging studies of attention deficit hyperactivity disorder?B J Casey
Am J Psychiatry 163:957-60. 2006 - Converging evidence for a fronto-basal-ganglia network for inhibitory control of action and cognitionAdam R Aron
Department of Psychology, University of California, San Diego, La Jolla, California 92093, USA
J Neurosci 27:11860-4. 2007