Robin Pf Dullaart

Summary

Affiliation: University Medical Center Groningen
Country: The Netherlands

Publications

  1. doi request reprint The positive relationship of serum paraoxonase-1 activity with apolipoprotein E is abrogated in metabolic syndrome
    Robin P F Dullaart
    Department of Endocrinology, University of Groningen, The Netherlands
    Atherosclerosis 230:6-11. 2013
  2. doi request reprint Role of HDL cholesterol and estimates of HDL particle composition in future development of type 2 diabetes in the general population: the PREVEND study
    Ali Abbasi
    Department of Epidemiology, University Medical Center Groningen, University of Groningen, Groningen 9700 RB, The Netherlands
    J Clin Endocrinol Metab 98:E1352-9. 2013
  3. doi request reprint The inverse relation of HDL anti-oxidative functionality with serum amyloid a is lost in metabolic syndrome subjects
    Robin P F Dullaart
    Department of Endocrinology, Center for Liver, Digestive and Metabolic Diseases, University Medical Center Groningen and University of Groningen, Groningen
    Obesity (Silver Spring) 21:361-6. 2013
  4. ncbi request reprint Statin and fibrate combination does not additionally lower plasma cholesteryl ester transfer in type 2 diabetes mellitus
    Rindert de Vries
    Department of Endocrinology, University Medical Center Groningen, University of Groningen, Groningen 9700 RB, The Netherlands
    Clin Lab 58:1231-9. 2012
  5. doi request reprint Lower carotid intima media thickness is predicted by higher serum bilirubin in both non-diabetic and Type 2 diabetic subjects
    Robin P F Dullaart
    Department of Endocrinology, University Medical Center Groningen, Groningen, The Netherlands
    Clin Chim Acta 414:161-5. 2012
  6. doi request reprint Pancreatic β-cell function relates positively to HDL functionality in well-controlled type 2 diabetes mellitus
    Robin P F Dullaart
    Department of Endocrinology, Center for Liver, Digestive and Metabolic Diseases, University Medical Center Groningen and University of Groningen, Groningen, The Netherlands
    Atherosclerosis 222:567-73. 2012
  7. doi request reprint Type 2 diabetes mellitus interacts with obesity and common variations in PLTP to affect plasma phospholipid transfer protein activity
    R P F Dullaart
    Department of Endocrinology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    J Intern Med 271:490-8. 2012
  8. pmc A role for CETP TaqIB polymorphism in determining susceptibility to atrial fibrillation: a nested case control study
    Folkert W Asselbergs
    Department of Cardiology, University Medical Center Groningen, Groningen, The Netherlands
    BMC Med Genet 7:39. 2006
  9. pmc The first Dutch SDHB founder deletion in paraganglioma-pheochromocytoma patients
    Jean Pierre Bayley
    Department of Human Genetics, Leiden University Medical Center, Leiden, The Netherlands
    BMC Med Genet 10:34. 2009
  10. doi request reprint HDL cholesterol response to GH replacement is associated with common cholesteryl ester transfer protein gene variation (-629C>A) and modified by glucocorticoid treatment
    Robin P F Dullaart
    Department of Endocrinology Laboratory Centre, University of Groningen and University Medical Centre Groningen, PO Box 30001, 9700 RB Groningen, The Netherlands
    Eur J Endocrinol 162:227-34. 2010

Collaborators

Detail Information

Publications75

  1. doi request reprint The positive relationship of serum paraoxonase-1 activity with apolipoprotein E is abrogated in metabolic syndrome
    Robin P F Dullaart
    Department of Endocrinology, University of Groningen, The Netherlands
    Atherosclerosis 230:6-11. 2013
    ..Here we determined relationships of serum PON-1 activity with apoE in subjects without and with metabolic syndrome (MetS)...
  2. doi request reprint Role of HDL cholesterol and estimates of HDL particle composition in future development of type 2 diabetes in the general population: the PREVEND study
    Ali Abbasi
    Department of Epidemiology, University Medical Center Groningen, University of Groningen, Groningen 9700 RB, The Netherlands
    J Clin Endocrinol Metab 98:E1352-9. 2013
    ....
  3. doi request reprint The inverse relation of HDL anti-oxidative functionality with serum amyloid a is lost in metabolic syndrome subjects
    Robin P F Dullaart
    Department of Endocrinology, Center for Liver, Digestive and Metabolic Diseases, University Medical Center Groningen and University of Groningen, Groningen
    Obesity (Silver Spring) 21:361-6. 2013
    ..Anti-oxidative properties of high density lipoproteins (HDL) are relevant for atheroprotection. HDL carry serum amyloid A (SAA), which may impair HDL functionality. We questioned whether HDL anti-oxidative capacity is determined by SAA...
  4. ncbi request reprint Statin and fibrate combination does not additionally lower plasma cholesteryl ester transfer in type 2 diabetes mellitus
    Rindert de Vries
    Department of Endocrinology, University Medical Center Groningen, University of Groningen, Groningen 9700 RB, The Netherlands
    Clin Lab 58:1231-9. 2012
    ..We tested the extent to which plasma CET and cholesterol esterification (EST) are decreased by statin and fibrate combination therapy compared to statin and fibrate administration alone in type 2 diabetic patients...
  5. doi request reprint Lower carotid intima media thickness is predicted by higher serum bilirubin in both non-diabetic and Type 2 diabetic subjects
    Robin P F Dullaart
    Department of Endocrinology, University Medical Center Groningen, Groningen, The Netherlands
    Clin Chim Acta 414:161-5. 2012
    ..We assessed relationships of IMT with serum total bilirubin in non-diabetic and Type 2 diabetic subjects without clinically manifest cardiovascular disease...
  6. doi request reprint Pancreatic β-cell function relates positively to HDL functionality in well-controlled type 2 diabetes mellitus
    Robin P F Dullaart
    Department of Endocrinology, Center for Liver, Digestive and Metabolic Diseases, University Medical Center Groningen and University of Groningen, Groningen, The Netherlands
    Atherosclerosis 222:567-73. 2012
    ....
  7. doi request reprint Type 2 diabetes mellitus interacts with obesity and common variations in PLTP to affect plasma phospholipid transfer protein activity
    R P F Dullaart
    Department of Endocrinology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    J Intern Med 271:490-8. 2012
    ..We investigated whether the diabetic state is able to amplify relationships between obesity and PLTP gene variations with circulating PLTP levels...
  8. pmc A role for CETP TaqIB polymorphism in determining susceptibility to atrial fibrillation: a nested case control study
    Folkert W Asselbergs
    Department of Cardiology, University Medical Center Groningen, Groningen, The Netherlands
    BMC Med Genet 7:39. 2006
    ..We aimed to investigate the association between several environmental factors and loci of candidate genes, which might be related to the presence of AF...
  9. pmc The first Dutch SDHB founder deletion in paraganglioma-pheochromocytoma patients
    Jean Pierre Bayley
    Department of Human Genetics, Leiden University Medical Center, Leiden, The Netherlands
    BMC Med Genet 10:34. 2009
    ..The majority of variants of the SDH genes are missense and nonsense mutations. To date few large deletions of the SDH genes have been described...
  10. doi request reprint HDL cholesterol response to GH replacement is associated with common cholesteryl ester transfer protein gene variation (-629C>A) and modified by glucocorticoid treatment
    Robin P F Dullaart
    Department of Endocrinology Laboratory Centre, University of Groningen and University Medical Centre Groningen, PO Box 30001, 9700 RB Groningen, The Netherlands
    Eur J Endocrinol 162:227-34. 2010
    ..We determined the extent to which the changes in HDL-C in response to GH replacement are predicted by the -629C>A CETP promoter polymorphism, and questioned whether this association is modified by concomitant glucocorticoid treatment...
  11. doi request reprint Plasma apolipoprotein M is reduced in metabolic syndrome but does not predict intima media thickness
    Robin P F Dullaart
    Department of Endocrinology, University Medical Center Groningen and University of Groningen, Groningen, The Netherlands
    Clin Chim Acta 406:129-33. 2009
    ..Plasma apoM is decreased in obese mouse models. We hypothesized that plasma apoM is lower in metabolic syndrome (MetS) subjects, and determined whether intima media thickness (IMT) is associated with apoM...
  12. ncbi request reprint The association of HDL cholesterol concentration with the -629C>A CETP promoter polymorphism is not fully explained by its relationship with plasma cholesteryl ester transfer
    R P F Dullaart
    Department of Endocrinology, University of Groningen, Hanzeplein 1, PO Box 30 001, 9700 RB Groningen, The Netherlands
    Scand J Clin Lab Invest 68:99-105. 2008
    ..In this study, we determined the contributions of the CETP -629 C>A genotype, plasma CETP mass and cholesteryl ester transfer to HDL cholesterol...
  13. doi request reprint High plasma lecithin:cholesterol acyltransferase activity does not predict low incidence of cardiovascular events: possible attenuation of cardioprotection associated with high HDL cholesterol
    Robin P F Dullaart
    Department of Endocrinology, University of Groningen and University Medical Center Groningen, PO Box 30001, 9700 RB Groningen, The Netherlands
    Atherosclerosis 208:537-42. 2010
    ..001). These HRs were unchanged after non-HDL cholesterol and triglyceride adjustment. In conclusion, high plasma LCAT activity does not predict reduced CVD risk, and may attenuate cardioprotection associated with higher HDL cholesterol...
  14. ncbi request reprint Plasma semicarbazide-sensitive amine oxidase is moderately decreased by pronounced exogenous hyperinsulinemia but is not associated with insulin sensitivity and body fat
    R P F Dullaart
    Department of Endocrinology, Groningen University Medical Center, University of Groningen, Groningen, The Netherlands
    Scand J Clin Lab Invest 66:559-65. 2006
    ..We tested the relationships of soluble SSAO, as reflected by its plasma activity, with insulin sensitivity and indices of body fat, and determined whether insulin is involved in regulating plasma SSAO activity...
  15. doi request reprint Common variation in the CETP gene and the implications for cardiovascular disease and its treatment: an updated analysis
    Robin P F Dullaart
    Department of Endocrinology, University Medical Center Groningen, PO Box 30 001, 9700 RB Groningen, The Netherlands
    Pharmacogenomics 9:747-63. 2008
    ..Likewise, no definite conclusion can be made at present concerning the effect of this CETP polymorphism on the lipid response to diet intervention...
  16. ncbi request reprint CETP inhibition in cardiovascular risk management: a critical appraisal
    R P F Dullaart
    University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    Eur J Clin Invest 37:90-8. 2007
    ..We propose that low HDL cholesterol in the context of high triglycerides, such as found in type 2 diabetes mellitus, could become an important indication area for this new class of drugs...
  17. doi request reprint Glucocorticoid replacement is associated with hypertriglyceridaemia, elevated glucose and higher non-HDL cholesterol and may diminish the association of HDL cholesterol with the -629C>A CETP promoter polymorphism in GH-receiving hypopituitary patients
    Robin P F Dullaart
    Department of Endocrinology, University of Groningen, University Medical Centre Groningen, Groningen, The Netherlands
    Clin Endocrinol (Oxf) 69:359-66. 2008
    ....
  18. doi request reprint High plasma C-reactive protein (CRP) is related to low paraoxonase-I (PON-I) activity independently of high leptin and low adiponectin in type 2 diabetes mellitus
    Robin P F Dullaart
    Department of Endocrinology, University Medical Centre Groningen, University of Groningen, Groningen, The Netherlands
    Clin Endocrinol (Oxf) 70:221-6. 2009
    ..In type 2 diabetic and control subjects, we determined the relationship of CRP with paraoxonase-I when taking account of plasma levels of pro- and anti-inflammatory adipokines...
  19. ncbi request reprint Lower plasma adiponectin is a marker of increased intima-media thickness associated with type 2 diabetes mellitus and with male gender
    Robin P F Dullaart
    Department of Endocrinology, University Medical Center Groningen, University of Groningen, PO Box 30 001, 9700 RB Groningen, The Netherlands
    Eur J Endocrinol 156:387-94. 2007
    ....
  20. doi request reprint Serum paraoxonase-I activity is unaffected by short-term administration of simvastatin, bezafibrate, and their combination in type 2 diabetes mellitus
    R P F Dullaart
    University of Groningen and University Medical Centre Groningen, Groningen, The Netherlands
    Eur J Clin Invest 39:200-3. 2009
    ..We studied whether statin and fibrate treatment, alone and in combination, affect serum paraoxonase-I activity in conjunction with changes in HDL cholesterol in diabetic patients...
  21. doi request reprint Fibroblast cholesterol efflux to plasma from metabolic syndrome subjects is not defective despite low high-density lipoprotein cholesterol
    Robin P F Dullaart
    Department of Endocrinology, University of Groningen and University Medical Center Groningen, PO Box 30001, 9700 RB Groningen, The Netherlands
    Eur J Endocrinol 158:53-60. 2008
    ....
  22. ncbi request reprint Phospholipid transfer protein activity is determined by type 2 diabetes mellitus and metabolic syndrome, and is positively associated with serum transaminases
    Robin P F Dullaart
    Department of Endocrinology, University of Groningen and University Medical Centre Groningen, Groningen, The Netherlands
    Clin Endocrinol (Oxf) 68:375-81. 2008
    ..In this study, we examined the relationship between plasma PLTP activity and liver enzymes in subjects with and without DM and MetS...
  23. doi request reprint Plasma lecithin: cholesterol acyltransferase activity modifies the inverse relationship of C-reactive protein with HDL cholesterol in nondiabetic men
    R P F Dullaart
    Department of Endocrinology, University of Groningen and University Medical Center Groningen, PO Box 30001, 9700 RB Groningen, The Netherlands
    Biochim Biophys Acta 1801:84-8. 2010
    ..It is hypothesized that LCAT could mitigate HDL's anti-inflammatory or antioxidative properties at higher HDL-C concentrations...
  24. doi request reprint Plasma lecithin: cholesterol acyltransferase activity is elevated in metabolic syndrome and is an independent marker of increased carotid artery intima media thickness
    Robin P F Dullaart
    Department of Endocrinology, University Medical Center Groningen, P O Box 30001, 9700 RB Groningen, The Netherlands
    J Clin Endocrinol Metab 93:4860-6. 2008
    ....
  25. ncbi request reprint Carotid artery intima media thickness is inversely related to serum free thyroxine in euthyroid subjects
    Robin P F Dullaart
    Department of Endocrinology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    Clin Endocrinol (Oxf) 67:668-73. 2007
    ..In euthyroid subjects, we determined whether carotid artery intima media thickness (IMT), a measure of subclinical atherosclerosis, is related to thyroid function...
  26. doi request reprint Carotid intima media thickness is associated with plasma adiponectin but not with the leptin:adiponectin ratio independently of metabolic syndrome
    Robin P F Dullaart
    Department of Endocrinology, University Medical Centre Groningen and University of Groningen, Groningen, The Netherlands
    Atherosclerosis 211:393-6. 2010
    ..We determined associations of carotid intima media thickness (IMT) with the L:A ratio taking account of cardiovascular risk factors in a high risk population...
  27. doi request reprint Plasma cholesteryl ester transfer, but not cholesterol esterification, is related to lipoprotein-associated phospholipase A2: possible contribution to an atherogenic lipoprotein profile
    Robin P F Dullaart
    Department of Endocrinology, University of Groningen and University Medical Center Groningen, 9700 RB Groningen, The Netherlands
    J Clin Endocrinol Metab 96:1077-84. 2011
    ....
  28. ncbi request reprint Type 2 diabetes mellitus is associated with differential effects on plasma cholesteryl ester transfer protein and phospholipid transfer protein activities and concentrations
    R P F Dullaart
    Department of Endocrinology, State University Hospital, Groningen, The Netherlands
    Scand J Clin Lab Invest 64:205-15. 2004
    ..Human plasma contains two lipid transfer proteins, cholesteryl ester transfer protein (CETP) and phospholipid transfer protein (PLTP), which are crucial in reverse cholesterol transport...
  29. doi request reprint Atorvastatin affects low density lipoprotein and non-high density lipoprotein cholesterol relations with apolipoprotein B in type 2 diabetes mellitus: modification by triglycerides and cholesteryl ester transfer protein
    Paul Jwh Kappelle
    University Medical Centre Groningen, Department of Endocrinology, P O Box 30001 9700 RB Groningen, The Netherlands
    Expert Opin Ther Targets 13:743-51. 2009
    ..Non-HDL-cholesterol (non-HDL-C) and apolipoprotein (apo) B are proposed as treatment targets. The extent to which statin therapy affects relationships of LDL-C and non-HDL-C with apoB was examined in type 2 diabetes...
  30. ncbi request reprint Increased cholesterol efflux from cultured fibroblasts to plasma from hypertriglyceridemic type 2 diabetic patients: roles of pre beta-HDL, phospholipid transfer protein and cholesterol esterification
    R De Vries
    Department of Endocrinology, University Medical Centre Groningen, University of Groningen, PO Box 30 001, Groningen, 9700 RB, The Netherlands
    Atherosclerosis 196:733-41. 2008
    ..Unaltered pre beta-HDL formation in diabetic hypertriglyceridemia, despite low apo A-I, could contribute to maintenance of cholesterol efflux...
  31. doi request reprint The ability of plasma to stimulate fibroblast cholesterol efflux is associated with the -629C-->A cholesteryl ester transfer protein promoter polymorphism: role of lecithin: cholesterol acyltransferase activity
    S E Borggreve
    Department of Endocrinology, University of Groningen and University Medical Center Groningen, Groningen, The Netherlands
    Biochim Biophys Acta 1781:10-5. 2008
    ....
  32. ncbi request reprint Antiproteinuric therapy decreases LDL-cholesterol as well as HDL-cholesterol in non-diabetic proteinuric patients: relationships with cholesteryl ester transfer protein mass and adiponectin
    J A Krikken
    University Medical Center Groningen, Division of Nephrology, Hanzeplein 1, Department of Internal Medicine, 9713 GZ Groningen, The Netherlands
    Expert Opin Ther Targets 13:497-504. 2009
    ....
  33. ncbi request reprint Elevated plasma phospholipid transfer protein activity is a determinant of carotid intima-media thickness in type 2 diabetes mellitus
    R De Vries
    Department of Endocrinology, University Medical Center Groningen, University of Groningen, P O Box 30 001, RB 9700 Groningen, The Netherlands
    Diabetologia 49:398-404. 2006
    ..We analysed the relationship between carotid artery intima-media thickness (IMT), an established marker of atherosclerosis, and PLTP activity in diabetic patients and control subjects...
  34. ncbi request reprint Life expectancy in differentiated thyroid cancer: a novel approach to survival analysis
    T P Links
    Department of Endocrinology, University Hospital Center Groningen, P O Box 30 001, 9700 RB Groningen, The Netherlands
    Endocr Relat Cancer 12:273-80. 2005
    ..Overall, treatment including radioiodine is safe but unsuccessful in 20% of the patients. Age is not a disease-specific risk factor and should not be used as an independent factor in treatment algorithms...
  35. ncbi request reprint Cellular cholesterol efflux to plasma from moderately hypercholesterolaemic type 1 diabetic patients is enhanced, and is unaffected by simvastatin treatment
    R De Vries
    Department of Endocrinology, University of Groningen and University Medical Center Groningen, P O Box 30 001, Groningen, 9700, The Netherlands
    Diabetologia 48:1105-13. 2005
    ..Cellular cholesterol efflux to plasma is important in reverse cholesterol transport and may be affected by simvastatin in type 1 diabetes mellitus...
  36. ncbi request reprint [Tissue-specific changes in cortisol metabolism and their potential role in the metabolic syndrome]
    M N Kerstens
    Universitair Medisch Centrum Groningen, Afd Endocrinologie, Postbus 30 001, 9700 RB Groningen
    Ned Tijdschr Geneeskd 149:871-6. 2005
    ..Pharmacological inhibition of IIbettaHSD type I activity provides an interesting mechanism for the development of novel therapeutic agents for type-2 diabetes mellitus...
  37. ncbi request reprint Decreased cortisol production in male type 1 diabetic patients
    M N Kerstens
    Department of Endocrinology, University Hospital Groningen, PO Box 30 001, 9700 RB Groningen, The Netherlands
    Eur J Clin Invest 33:589-94. 2003
    ..It is unclear whether cortisol production and the 11betaHSD-mediated cortisol to cortisone interconversion are different between type 1 diabetic patients and healthy subjects...
  38. ncbi request reprint Human plasma phospholipid transfer protein activity is decreased by acute hyperglycaemia: studies without and with hyperinsulinaemia in Type 1 diabetes mellitus
    P H N Oomen
    Department of Endocrinology, University Hospital Groningen, Groningen, The Netherlands
    Diabet Med 22:768-74. 2005
    ..In the present study, we evaluated the separate effects of hyperglycaemia and hyperinsulinaemia in C-peptide-negative Type 1 diabetic patients...
  39. ncbi request reprint No effects of acute hyperglycaemia and hyperinsulinaemia on skin microcirculation and endothelial markers in Type II diabetes mellitus
    P H N Oomen
    Department of Internal Medicine, Division of General Internal Medicine, University Hospital, Groningen, The Netherlands
    Scand J Clin Lab Invest 64:119-27. 2004
    ....
  40. ncbi request reprint Short-term moderate sodium restriction induces relative hyperfiltration in normotensive normoalbuminuric Type I diabetes mellitus
    P T Luik
    Department of Medicine, Division of Nephrology, University Hospital, Groningen, The Netherlands
    Diabetologia 45:535-41. 2002
    ..Sodium restriction might seem a logical form of treatment but data on its renal effects is conflicting. We therefore studied the effects of sodium restriction on renal haemodynamics in uncomplicated Type I diabetes mellitus...
  41. ncbi request reprint The influence of the ACE ( I/D) polymorphism on systemic and renal vascular responses to angiotensins in normotensive, normoalbuminuric Type 1 diabetes mellitus
    P T Luik
    Department of Internal Medicine, Division of Nephrology, University Hospital Groningen, Hanzeplein 1, PO Box 30 001, 9700 RB, Groningen, The Netherlands
    Diabetologia 46:1131-9. 2003
    ..To analyse these consequences, we assessed renal and systemic responsiveness to angiotensin I infusion, with the response to angiotensin II as reference...
  42. ncbi request reprint Alterations in high-density lipoprotein metabolism and reverse cholesterol transport in insulin resistance and type 2 diabetes mellitus: role of lipolytic enzymes, lecithin:cholesterol acyltransferase and lipid transfer proteins
    S E Borggreve
    Department of Endocrinology, University Hospital Groningen, Groningen, The Netherlands
    Eur J Clin Invest 33:1051-69. 2003
    ....
  43. doi request reprint Assessing the functional properties of high-density lipoproteins: an emerging concept in cardiovascular research
    Michela Triolo
    Department of Pediatrics, University of Groningen, University Medical Center Groningen, Hanzeplein 1, 9713 GZ Groningen, The Netherlands
    Biomark Med 7:457-72. 2013
    ....
  44. ncbi request reprint Low plasma aldosterone despite normal plasma renin activity in uncomplicated type 1 diabetes mellitus: effects of RAAS stimulation
    P T Luik
    University Hospital Groningen, and Martini Ziekenhuis, Groningen, The Netherlands
    Eur J Clin Invest 33:787-93. 2003
    ..Therefore, we studied plasma renin activity and plasma aldosterone in uncomplicated type 1 diabetes mellitus by evaluating the effects of endogenous (sodium restriction) and exogenous (angiotensin I infusion) stimulation...
  45. ncbi request reprint A low-saturated-fat, low-cholesterol diet decreases plasma CETP activity and pre beta-HDL formation but does not affect cellular cholesterol efflux to plasma from type 1 diabetic patients
    R De Vries
    Department of Endocrinology, University of Groningen and University Medical Center, Groningen
    Scand J Clin Lab Invest 65:729-37. 2005
    ..Reduction in dietary saturated fat and cholesterol intake does not adversely affect cellular cholesterol efflux to plasma from type 1 diabetic patients, despite a drop in pre beta-HDL formation...
  46. ncbi request reprint Treatment with intramuscular vascular endothelial growth factor gene compared with placebo for patients with diabetes mellitus and critical limb ischemia: a double-blind randomized trial
    Y H Kusumanto
    Department of Internal Medicine, University of Groningen and University Medical Center Groningen, 9700 RB Groningen, The Netherlands
    Hum Gene Ther 17:683-91. 2006
    ..However, significant and meaningful improvement was found in patients treated with a VEGF165-containing plasmid. There were no substantial adverse events...
  47. ncbi request reprint Outcome in patients with differentiated thyroid cancer with negative diagnostic whole-body scanning and detectable stimulated thyroglobulin
    K M van Tol
    Department of Endocrinology, University Hospital Groningen, University of Groningen, The Netherlands
    Eur J Endocrinol 148:589-96. 2003
    ..High-dose iodine-131 treatment of patients who have a negative (131)I diagnostic whole-body scan (WBS) is advocated. However, the therapeutic benefit of this "blind" treatment is not clear...
  48. ncbi request reprint Plasma adiponectin is modestly decreased during 24-hour insulin infusion but not after inhibition of lipolysis by Acipimox
    R P F Dullaart
    Department of Endocrinology, Groningen University Medical Center, The Netherlands
    Scand J Clin Lab Invest 65:523-31. 2005
    ..We tested the hypothesis that prolonged exogenous insulin infusion decreases plasma adiponectin, and examined whether a possible effect of insulin on plasma adiponectin is attributable to inhibition of lipolysis...
  49. ncbi request reprint Plasma cholesteryl ester transfer protein mass and phospholipid transfer protein activity are associated with leptin in type 2 diabetes mellitus
    R P F Dullaart
    Department of Endocrinology, University of Groningen and University Medical Center Groningen, Groningen, The Netherlands
    Biochim Biophys Acta 1771:113-8. 2007
    ..In conclusion, both plasma CETP mass and PLTP activity are associated with plasma leptin in type 2 diabetes. The elevated CET in these patients is not independently related to any of the measured plasma adipokines...
  50. ncbi request reprint Acute hyperglycemia and hyperinsulinemia enhance vasodilatation in Type 1 diabetes mellitus without increasing capillary permeability and inducing endothelial dysfunction
    P H N Oomen
    Division of General Internal Medicine, University Hospital Groningen, Hanzeplein 1, 9700 RB, Groningen, The Netherlands
    Microvasc Res 63:1-9. 2002
    ..The acute hyperglycemia- and hyperinsulinemia-induced vasodilatation is not accompanied by changes in microvascular permeability or endothelial markers...
  51. ncbi request reprint Malignant aldosterone-producing adrenal tumour: reoccurrence with glucocorticoid excess without hyperaldosteronism
    E M Abma
    Department of Endocrinology, University Medical Center Hospital Groningen, University of Groningen, Groningen, The Netherlands
    Neth J Med 66:252-5. 2008
    ..Although malignant aldosterone-producing adrenal tumours are very rare, the present case underscores that clinicians should be aware that primary hyperaldosteronism can occur in the context of adrenocortical carcinoma...
  52. ncbi request reprint Salt loading affects cortisol metabolism in normotensive subjects: relationships with salt sensitivity
    Michiel N Kerstens
    Departments of Endocrinology, University Hospital Groningen, 9700 RB Groningen, The Netherlands
    J Clin Endocrinol Metab 88:4180-5. 2003
    ..Changes in circulating cortisol might contribute to individual sodium-induced alterations in insulin sensitivity...
  53. ncbi request reprint Post-heparin plasma lipoprotein lipase, but not hepatic lipase activity, is related to plasma adiponectin in type 2 diabetic patients and healthy subjects
    Rindert de Vries
    Department of Endocrinology, Groningen University Medical Center, Groningen, The Netherlands
    Clin Lab 51:403-9. 2005
    ..It seems unlikely that plasma adiponectin predicts the effects of the diabetic state as such on high plasma triglycerides and low HDL cholesterol...
  54. ncbi request reprint The effect of cholesteryl ester transfer protein -629C->A promoter polymorphism on high-density lipoprotein cholesterol is dependent on serum triglycerides
    Susanna E Borggreve
    Department of Endocrinology, University Medical Centre Groningen, P O Box 30 001, 9700 RB Groningen, The Netherlands
    J Clin Endocrinol Metab 90:4198-204. 2005
    ..The effect of the closely linked CETP TaqIB polymorphism on HDL-C has been suggested to be modified by obesity and hyperinsulinemia...
  55. ncbi request reprint Role of lipases, lecithin:cholesterol acyltransferase and cholesteryl ester transfer protein in abnormal high density lipoprotein metabolism in insulin resistance and type 2 diabetes mellitus
    Rindert de Vries
    Department of Endocrinology, University Hospital Groningen, The Netherlands
    Clin Lab 49:601-13. 2003
    ....
  56. ncbi request reprint Cellular cholesterol efflux to plasma from proteinuric patients is elevated and remains unaffected by antiproteinuric treatment
    Liffert Vogt
    Department of Internal Medicine, Division of Nephrology, room 4 045, University Medical Center Groningen, University of Groningen, Hanzeplein 1, 9718 NX Groningen, The Netherlands
    Nephrol Dial Transplant 21:101-6. 2006
    ..The first step in RCT, cellular cholesterol efflux to plasma, may be altered in proteinuria, consequent to changes in pre-beta high-density lipoprotein (HDL) formation and plasma phospholipid transfer protein (PLTP) activity...
  57. ncbi request reprint Plasma cholesteryl ester transfer is a determinant of intima-media thickness in type 2 diabetic and nondiabetic subjects: role of CETP and triglycerides
    Rindert de Vries
    Department of Endocrinology, University Medical Center Groningen, P O Box 30001, 9700 RB, Hanzeplein 1, Groningen, 9713 GZ Netherlands
    Diabetes 54:3554-9. 2005
    ..These data, therefore, provide a rationale to evaluate the effects of CETP inhibitor treatment on plasma CET and on cardiovascular risk in diabetes-associated hypertriglyceridemia...
  58. ncbi request reprint An increased coronary risk is paradoxically associated with common cholesteryl ester transfer protein gene variations that relate to higher high-density lipoprotein cholesterol: a population-based study
    Susanna E Borggreve
    Department of Endocrinology, University Medical Center Groningen and University of Groningen, Hanzeplein 1, P O Box 30 001, 9700 RB Groningen, The Netherlands
    J Clin Endocrinol Metab 91:3382-8. 2006
    ....
  59. ncbi request reprint Immediate postoperative radiotherapy in residual nonfunctioning pituitary adenoma: beneficial effect on local control without additional negative impact on pituitary function and life expectancy
    Alfons C M van den Bergh
    Department of Radiation Oncology, University Medical Center Groningen, Groningen, The Netherlands
    Int J Radiat Oncol Biol Phys 67:863-9. 2007
    ..To demonstrate the benefit of immediate postoperative radiotherapy in residual nonfunctioning pituitary adenoma (NFA) in perspective to the need for hormonal substitution and life expectancy...
  60. ncbi request reprint Low dietary sodium and exogenous angiotensin II infusion decrease plasma adiponectin concentrations in healthy men
    A Titia Lely
    Department of Internal Medicine, Division of Nephrology, Hanzeplein 1, 9713 GZ Groningen, The Netherlands
    J Clin Endocrinol Metab 92:1821-6. 2007
    ..Adiponectin has antiinflammatory and vascular protective effects and may improve insulin sensitivity. Animal data suggest a role of the renin-angiotensin aldosterone system (RAAS) in the regulation of adiponectin...
  61. ncbi request reprint High plasma cholesteryl ester transfer protein levels may favour reduced incidence of cardiovascular events in men with low triglycerides
    Susanna E Borggreve
    Department of Endocrinology, University Medical Centre Groningen, University of Groningen, Hanzeplein 1, PO Box 30 001, 9700 RB Groningen, The Netherlands
    Eur Heart J 28:1012-8. 2007
    ..We determined the relationship of plasma CETP with incident CVD in a population with relatively low triglycerides...
  62. ncbi request reprint Concerted actions of cholesteryl ester transfer protein and phospholipid transfer protein in type 2 diabetes: effects of apolipoproteins
    Geesje M Dallinga-Thie
    Department of Vascular Medicine, Erasmus University Medical Center, Rotterdam, The Netherlands
    Curr Opin Lipidol 18:251-7. 2007
    ..Plasma lipid transfer proteins play an essential role in lipoprotein metabolism. It is thus vital to understand their pathophysiology and determine which factors influence their functioning in type 2 diabetes...
  63. ncbi request reprint Letter in response to recent paper by Fournier et al
    Robin P F Dullaart
    Atherosclerosis 164:379-80. 2002
  64. ncbi request reprint Analysis of cortisol and other stress-related hormones in patients with Ménière's disease
    Nynke Van Cruijsen
    Department of Otorhinolaryngology, University Medical Centre Groningen, Groningen, The Netherlands
    Otol Neurotol 26:1214-9. 2005
    ..To evaluate cortisol and catecholamine levels in patients with Ménière's disease...
  65. ncbi request reprint Cortisol metabolism and glucose intolerance
    Michiel N Kerstens
    J Clin Endocrinol Metab 88:2951; author reply 2951-2. 2003
  66. ncbi request reprint Lipid management in the proteinuric patient: do not overlook the importance of proteinuria reduction
    Liffert Vogt
    Department of Internal Medicine, Division of Nephrology, University Medical Center Groningen, Hanzeplein 1, 9713 GX Groningen, The Netherlands
    Nephrol Dial Transplant 19:5-8. 2004
  67. ncbi request reprint Salt sensitivity and 11beta-hydroxysteroid dehydrogenase type 2 activity
    Michiel N Kerstens
    Am J Hypertens 17:283-4. 2004
  68. ncbi request reprint Angiotensin administration stimulates renal 11 beta-hydroxysteroid dehydrogenase activity in healthy men
    Michiel N Kerstens
    Department of Endocrinology, University Hospital Groningen, Groningen, The Netherlands
    Kidney Int 65:2065-70. 2004
    ....
  69. ncbi request reprint Lack of radiation optic neuropathy in 72 patients treated for pituitary adenoma
    Alfons C M van den Bergh
    Department of Radiation Oncology, University Hospital Groningen, PPO Box 30 001, 9700 RB Groningen, The Netherlands
    J Neuroophthalmol 24:200-5. 2004
    ..53% (95% CI, 0.26%-0.96%). An additional 14 single RON cases have been reported, bringing the total of adequately documented RON cases to 25. RON is a rare complication after external beam radiation therapy for NFA...
  70. ncbi request reprint A novel apoA-I mutation (L178P) leads to endothelial dysfunction, increased arterial wall thickness, and premature coronary artery disease
    G Kees Hovingh
    Department of Vascular Medicine, Academic Medical Center, Amsterdam, The Netherlands
    J Am Coll Cardiol 44:1429-35. 2004
    ..We investigated the consequences of an apolipoprotein A-I (apoA-I) gene defect with regard to lipid metabolism, endothelial function, arterial wall thickness, and coronary artery disease (CAD) risk...
  71. ncbi request reprint Diagnostic I-131 scintigraphy in patients with differentiated thyroid cancer: no additional value of higher scan dose
    Thi T H Phan
    Department of Endocrinology, University Hospital Groningen, The Netherlands
    Ann Nucl Med 18:641-6. 2004
    ..The applied diagnostic I-131 doses vary between 37 and 370 MBq. The aim of this study was to determine the yield of a diagnostic scan with 370 MBq I-131 in patients with a negative diagnostic scan with 74 MBq I-131...
  72. ncbi request reprint Derangements of intravascular remodeling of lipoproteins in type 2 diabetes mellitus: consequences for atherosclerosis development
    Geesje M Dallinga-Thie
    Laboratory of Experimental Vascular Medicine G1 113, Academic Medical Center Amsterdam, PO Box 22660, 1100DD Amsterdam, The Netherlands
    Curr Diab Rep 8:65-70. 2008
    ..Despite low HDL cholesterol, plasma's ability to stimulate cellular cholesterol efflux, reflecting an early step in the reverse cholesterol transport pathway, appears to be maintained, perhaps implicating a compensatory mechanism...
  73. ncbi request reprint Plasma phospholipid transfer protein activity, a determinant of HDL kinetics in vivo
    Robin P F Dullaart
    Clin Endocrinol (Oxf) 67:316-7; author reply 317. 2007
  74. doi request reprint Association of cholesteryl ester transfer protein genotypes with CETP mass and activity, lipid levels, and coronary risk
    Alexander Thompson
    Department of Public Health and Primary Care, University of Cambridge, Strangeways Research Laboratory, Worts Causeway, Cambridge, England CB1 8RN
    JAMA 299:2777-88. 2008
    ..The importance of the cholesteryl ester transfer protein (CETP) pathway in coronary disease is uncertain. Study of CETP genotypes can help better understand the relevance of this pathway to lipid metabolism and disease risk...
  75. ncbi request reprint Better yield of (18)fluorodeoxyglucose-positron emission tomography in patients with metastatic differentiated thyroid carcinoma during thyrotropin stimulation
    Karin M van Tol
    Department of Endocrinology, University Hospital Groningen, The Netherlands
    Thyroid 12:381-7. 2002
    ..To detect metastatic or recurrent differentiated thyroid carcinoma FDG-PET should be performed during hypothyroidism, leading to TSH stimulation...