Research Topics
| Edward DompelingSummaryAffiliation: University Hospital Maastricht Country: The Netherlands Publications
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Detail Information
Publications
Biomarkers in exhaled breath condensate indicate presence and severity of cystic fibrosis in childrenCharlotte M H H T Robroeks
Department of Paediatric Pulmonology, University Hospital Maastricht, Maastricht, The Netherlands
Pediatr Allergy Immunol 19:652-9. 2008..Longitudinal data are necessary to further confirm the role of these markers for the management of CF in children...
Cytokines in exhaled breath condensate of children with asthma and cystic fibrosisCharlotte M H H T Robroeks
Department of Paediatric Pulmonology, University Hospital Maastricht, Maastricht, The Netherlands
Ann Allergy Asthma Immunol 96:349-55. 2006..Inflammatory mediators in exhaled breath condensate (EBC) indicate ongoing inflammation in the lungs and might differentiate between asthma and cystic fibrosis (CF)...- Exhaled nitric oxide and biomarkers in exhaled breath condensate indicate the presence, severity and control of childhood asthmaC M H H T Robroeks
Department of Paediatric Pulmonology, University Hospital Maastricht, Maastricht, The Netherlands
Clin Exp Allergy 37:1303-11. 2007..Their ability to indicate an asthma diagnosis, and to assess asthma severity and control, is largely unknown... - Comparison of the anti-inflammatory effects of extra-fine hydrofluoroalkane-beclomethasone vs fluticasone dry powder inhaler on exhaled inflammatory markers in childhood asthmaCharlotte M H H T Robroeks
Department of Paediatric Pulmonology, University Hospital Maastricht, Maastricht, The Netherlands
Ann Allergy Asthma Immunol 100:601-7. 2008..Therefore, extra-fine hydrofluoroalkane-beclomethasone may be particularly useful for treating peripheral airway inflammation in asthma... - Structural lung changes, lung function, and non-invasive inflammatory markers in cystic fibrosisCharlotte M H H T Robroeks
Paediatric Pulmonology, University Hospital Maastricht, Maastricht, The Netherlands
Pediatr Allergy Immunol 21:493-500. 2010..Future longitudinal studies should reveal whether non-invasive monitoring of airway inflammation in CF adds to better follow-up of patients... - Feasibility of exhaled nitric oxide measurements at various flow rates in children with asthmaCharlotte M H H T Robroeks
University Hospital Maastricht, Department of Paediatric Pulmonology, Maastricht, The Netherlands
Pediatr Allergy Immunol 21:e222-8. 2010..A significant learning effect was present. The long-term reproducibility of alveolar and bronchial NO values during 6 months was moderate... - Prevention of asthma in genetically susceptible children: a multifaceted intervention trial focussed on feasibility in general practiceTanja Maas
Department of General Practice, Care and Public Health Research Institute, Maastricht University, Maastricht, The Netherlands
Pediatr Allergy Immunol 22:794-802. 2011..Although the effectiveness of the multifaceted allergen-reducing interventions for the prevention of asthma in susceptible children was showed to be proven, the feasibility was not clear... - Childhood asthma: exhaled markers of airway inflammation, asthma control score, and lung function testsPhilippe P R Rosias
Department of Pediatric Pulmonology, University Hospital Maastricht, The Netherlands
Pediatr Pulmonol 38:107-14. 2004..To further evaluate the clinical utility of exhaled markers in monitoring childhood asthma, more studies are required on a wider range of asthma severity, and preferably with repeated measurements of markers and of asthma control... - Elevated inflammatory markers at preschool age precede persistent wheezing at school ageKim D G van de Kant
Department of Paediatric Pulmonology, School for Public Health and Primary Care, Maastricht University Medical Centre, Maastricht, The Netherlands
Pediatr Allergy Immunol 23:259-64. 2012.... - Free radicals in exhaled breath condensate in cystic fibrosis and healthy subjectsPhilippe P R Rosias
Department of Pediatric Pulmonology, University Hospital of Maastricht, Maastricht, The Netherlands
Free Radic Res 40:901-9. 2006..Addition of hydrogen peroxide resulted in increased radical signal intensity. Detection of free radicals in EBC of children with CF and healthy subjects is feasible using EPR spectroscopy... - Interactive effect of family history and environmental factors on respiratory tract-related morbidity in infancySandra Kuiper
Department of General Practice, Care and Public Health Research Institute, University of Maastricht, Maastricht, The Netherlands
J Allergy Clin Immunol 120:388-95. 2007..Family and environmental factors affect the development of respiratory morbidity. How these factors interact is unclear... 
Early diagnosis of asthma in young children by using non-invasive biomarkers of airway inflammation and early lung function measurements: study protocol of a case-control studyKim D G van de Kant
Department of Paediatric Pulmonology, Maastricht University Medical Centre MUMC, Maastricht, The Netherlands
BMC Public Health 9:210. 2009..In addition, aetiological factors, including gene polymorphisms and gene expression profiles, in relation to the development of asthma are studied...- Impact of bacterial colonization on exhaled inflammatory markers in wheezing preschool childrenKim D G van de Kant
Department of Paediatric Pulmonology, School for Public Health and Primary Care CAPHRI, Maastricht University Medical Centre MUMC, PO Box 5800, 6202 AZ, Maastricht, The Netherlands
J Breath Res 6:046001. 2012..The various elevated exhaled inflammatory markers indicate increased airway inflammation in wheezing preschool children. In the presence of wheeze, we found no evidence for bacterial induced airway inflammation... - Actual asthma control in a paediatric outpatient clinic population: do patients perceive their actual level of control?Sanne C Hammer
Department of Paediatric Pulmonology, University Hospital Maastricht, Maastricht, The Netherlands
Pediatr Allergy Immunol 19:626-33. 2008..Poorly controlled disease was related to several aspects of asthma management, which are potentially accessible for improvements... - Exhaled breath condensate in children: pearls and pitfallsPhilippe P R Rosias
Division of Paediatric Respiratory Medicine, Department of Paediatrics, University Hospital Maastricht, Maastricht, The Netherlands
Pediatr Allergy Immunol 15:4-19. 2004..Meanwhile, when using this technique or when interpreting research data, one should be fully aware of the possible methodological pitfalls... - Structuring and validating a cost-effectiveness model of primary asthma prevention amongst childrenG Feljandro P Ramos
Department of General Practice, CAPHRI School for Public Health and Primary Care, Maastricht University, Maastricht, The Netherlands
BMC Med Res Methodol 11:150. 2011..In this paper, we describe a procedure to structure and validate a model for the primary prevention of asthma in children... - Chronic bronchiolitis in a 5-yr-old child after exposure to sulphur mustard gasE Dompeling
Dept of Paediatric Pulmonology, University Hospital Maastricht, The Netherlands
Eur Respir J 23:343-6. 2004..High resolution computed tomography scan showed multiple bronchiectasis. The histological picture of an open lung biopsy was best described as a "chronic bronchiolitis"... - Clinical use of exhaled volatile organic compounds in pulmonary diseases: a systematic reviewKim D G van de Kant
Department of Pediatric Pulmonology, School for Public Health and Primary Care CAPHRI, Maastricht University Medical Center MUMC, P, O, Box 5800, 6202, AZ, Maastricht, The Netherlands
Respir Res 13:117. 2012..Despite these promising findings, multiple challenges such as further standardization and validation of the diverse techniques need to be mastered before VOCs can be applied into clinical practice... - Exhaled breath profiling in diagnosing wheezy preschool childrenKim D G van de Kant
Dept of Paediatric Pulmonology, School for Public Health and Primary Care, Caphri, Maastricht University Medical Centre, Maastricht, The Netherlands
Eur Respir J 41:183-8. 2013..VOC profiles are able to distinguish children with and without recurrent wheeze with a reasonable accuracy. This proof of principle paves the way for additional research on VOCs in preschool wheezing... - Increased cytokines, chemokines and soluble adhesion molecules in exhaled breath condensate of asthmatic childrenC M H H T Robroeks
Department of Paediatric Pulmonology, Maastricht University Medical Centre, Maastricht, The Netherlands
Clin Exp Allergy 40:77-84. 2010..However, the use of a glass condenser system combined with a sensitive analytical technique may increase the possibility to assess these biomarkers in EBC in a reliable way... - Breath condenser coatings affect measurement of biomarkers in exhaled breath condensateP P Rosias
Dept of Paediatric Pulmonology, University Hospital Maastricht, Maastricht, The Netherlands
Eur Respir J 28:1036-41. 2006..Guidelines for exhaled breath condensate standardisation should include the most valid condenser coating to measure a specific biomarker... - Biomarker reproducibility in exhaled breath condensate collected with different condensersP P Rosias
Dept of Paediatric Pulmonology, Caphri Research Institute, University Hospital Maastricht, PO Box 5800, 6202 AZ Maastricht, The Netherlands
Eur Respir J 31:934-42. 2008..However, biomarker reproducibility in exhaled breath condensate in healthy adults was not influenced by the type of condenser... - Mode and place of delivery, gastrointestinal microbiota, and their influence on asthma and atopyFrederika A van Nimwegen
Department of Epidemiology, CAPHRI School for Public Health and Primary Care, Maastricht University Medical Centre, Maastricht, The Netherlands
J Allergy Clin Immunol 128:948-55.e1-3. 2011..However, results are inconsistent, and the hypothesized intermediate role of the microbiota in the association between birth mode and atopic manifestations has not been studied yet... - Volatile organic compounds in exhaled breath as a diagnostic tool for asthma in childrenJ W Dallinga
Department of Health Risk Analysis and Toxicology, Nutrition and Toxicology Research Institute Maastricht, Maastricht University, Maastricht, The Netherlands
Clin Exp Allergy 40:68-76. 2010..The correct diagnosis of asthma in young children is often hard to achieve, resulting in undertreatment of asthmatic children and overtreatment in transient wheezers... - A motivational interviewing intervention to PREvent PAssive Smoke Exposure (PREPASE) in children with a high risk of asthma: design of a randomised controlled trialSasha G Hutchinson
Department of Paediatric Pulmonology, Maastricht University Medical Centre MUMC CAPHRI School for Public Health and Primary Care, P O Box 616, Maastricht, MD 6200, The Netherlands
BMC Public Health 13:177. 2013..The aim of the PREPASE study is to test the effectiveness of such an intervention program towards eliminating or reducing of PS exposure in children at risk for asthma. This article describes the protocol of the PREPASE study... - A systematic review of CD14 and toll-like receptors in relation to asthma in Caucasian childrenEster MM Klaassen
Department of Paediatric Pulmonology, School for Public Health and Primary Care CAPHRI, Maastricht University Medical Centre MUMC, P, O, Box 5800, Maastricht, 6202 AZ, The Netherlands
Allergy Asthma Clin Immunol 9:10. 2013..Future studies should include haplotype analysis and take environmental factors into account to further clarify the role of CD14 and toll-like receptors on childhood asthma... - The primary prevention of asthma in children study: design of a multifaceted prevention programSandra Kuiper
Department of General Practice, Care and Public Health Research Institute, University of Maastricht, Maastricht, The Netherlands
Pediatr Allergy Immunol 16:321-31. 2005..Of these 92 infants, 45 (20 boys) were allocated to an intervention group and 47 (24 boys) to a control group. Until now all infants have been followed for at least 1 yr... - Environmental exposure reduction in high-risk newborns: where do we start?Hubert J A M Schönberger
Department of Family Practice, Research Institute ExTra, University Maastricht, Maastricht, The Netherlands
Ann Allergy Asthma Immunol 91:531-8. 2003.... - Association between first-degree familial predisposition of asthma and atopy (total IgE) in newbornsS Kuiper
Department of General Practice, University Hospital Maastricht, Maastricht, The Netherlands
Clin Exp Allergy 36:594-601. 2006..It is generally thought that infants with a first-degree familial predisposition of asthma are at higher risk of developing asthma than infants without predisposition... - The PREVASC study: the clinical effect of a multifaceted educational intervention to prevent childhood asthmaH J A M Schönberger
Dept of General Practice, Research Institute Caphri, University Maastricht, Maastricht, The Netherlands
Eur Respir J 25:660-70. 2005..Follow-up is necessary to confirm whether the intervention can actually prevent the development of asthma... - Compliance of asthmatic families with a primary prevention programme of asthma and effectiveness of measures to reduce inhalant allergens--a randomized trialH J A M Schönberger
Department of General Practice, Research Institute Caphri, University Maastricht, Maastricht, The Netherlands
Clin Exp Allergy 34:1024-31. 2004..Compliance to and the effect of pre- and post-natal exposure reduction measures to prevent asthma in high-risk children from asthmatic families were studied... - Randomised controlled study of clinical efficacy of spacer therapy in asthma with regard to electrostatic chargeE Dompeling
Department of Paediatric Pulmonology, University Hospital Maastricht, P Debyelaan 25, PO Box 5800, 6202 AZ Maastricht, Netherlands
Arch Dis Child 84:178-82. 2001..Several laboratory studies found a clear negative influence of electrostatic charge (ESC) on plastic spacers on the delivery of aerosol...