Edward Dompeling

Summary

Affiliation: University Hospital Maastricht
Country: The Netherlands

Publications

  1. doi Comparison of the anti-inflammatory effects of extra-fine hydrofluoroalkane-beclomethasone vs fluticasone dry powder inhaler on exhaled inflammatory markers in childhood asthma
    Charlotte M H H T Robroeks
    Department of Paediatric Pulmonology, University Hospital Maastricht, Maastricht, The Netherlands
    Ann Allergy Asthma Immunol 100:601-7. 2008
  2. ncbi Exhaled nitric oxide and biomarkers in exhaled breath condensate indicate the presence, severity and control of childhood asthma
    C M H H T Robroeks
    Department of Paediatric Pulmonology, University Hospital Maastricht, Maastricht, The Netherlands
    Clin Exp Allergy 37:1303-11. 2007
  3. ncbi Cytokines in exhaled breath condensate of children with asthma and cystic fibrosis
    Charlotte M H H T Robroeks
    Department of Paediatric Pulmonology, University Hospital Maastricht, Maastricht, The Netherlands
    Ann Allergy Asthma Immunol 96:349-55. 2006
  4. doi Biomarkers in exhaled breath condensate indicate presence and severity of cystic fibrosis in children
    Charlotte M H H T Robroeks
    Department of Paediatric Pulmonology, University Hospital Maastricht, Maastricht, The Netherlands
    Pediatr Allergy Immunol 19:652-9. 2008
  5. doi Structural lung changes, lung function, and non-invasive inflammatory markers in cystic fibrosis
    Charlotte M H H T Robroeks
    Paediatric Pulmonology, University Hospital Maastricht, Maastricht, The Netherlands
    Pediatr Allergy Immunol 21:493-500. 2010
  6. doi Feasibility of exhaled nitric oxide measurements at various flow rates in children with asthma
    Charlotte M H H T Robroeks
    University Hospital Maastricht, Department of Paediatric Pulmonology, Maastricht, The Netherlands
    Pediatr Allergy Immunol 21:e222-8. 2010
  7. doi Impact of bacterial colonization on exhaled inflammatory markers in wheezing preschool children
    Kim D G van de Kant
    Department of Paediatric Pulmonology, School for Public Health and Primary Care CAPHRI, Maastricht University Medical Centre MUMC, PO Box 5800, 6202 AZ, Maastricht, The Netherlands
    J Breath Res 6:046001. 2012
  8. doi Prevention of asthma in genetically susceptible children: a multifaceted intervention trial focussed on feasibility in general practice
    Tanja Maas
    Department of General Practice, Care and Public Health Research Institute, Maastricht University, Maastricht, The Netherlands
    Pediatr Allergy Immunol 22:794-802. 2011
  9. ncbi Childhood asthma: exhaled markers of airway inflammation, asthma control score, and lung function tests
    Philippe P R Rosias
    Department of Pediatric Pulmonology, University Hospital Maastricht, The Netherlands
    Pediatr Pulmonol 38:107-14. 2004
  10. doi Elevated inflammatory markers at preschool age precede persistent wheezing at school age
    Kim D G van de Kant
    Department of Paediatric Pulmonology, School for Public Health and Primary Care, Maastricht University Medical Centre, Maastricht, The Netherlands
    Pediatr Allergy Immunol 23:259-64. 2012

Detail Information

Publications36

  1. doi Comparison of the anti-inflammatory effects of extra-fine hydrofluoroalkane-beclomethasone vs fluticasone dry powder inhaler on exhaled inflammatory markers in childhood asthma
    Charlotte M H H T Robroeks
    Department of Paediatric Pulmonology, University Hospital Maastricht, Maastricht, The Netherlands
    Ann Allergy Asthma Immunol 100:601-7. 2008
    ..Therefore, extra-fine hydrofluoroalkane-beclomethasone may be particularly useful for treating peripheral airway inflammation in asthma...
  2. ncbi Exhaled nitric oxide and biomarkers in exhaled breath condensate indicate the presence, severity and control of childhood asthma
    C M H H T Robroeks
    Department of Paediatric Pulmonology, University Hospital Maastricht, Maastricht, The Netherlands
    Clin Exp Allergy 37:1303-11. 2007
    ..Their ability to indicate an asthma diagnosis, and to assess asthma severity and control, is largely unknown...
  3. ncbi Cytokines in exhaled breath condensate of children with asthma and cystic fibrosis
    Charlotte M H H T Robroeks
    Department of Paediatric Pulmonology, University Hospital Maastricht, Maastricht, The Netherlands
    Ann Allergy Asthma Immunol 96:349-55. 2006
    ..Inflammatory mediators in exhaled breath condensate (EBC) indicate ongoing inflammation in the lungs and might differentiate between asthma and cystic fibrosis (CF)...
  4. doi Biomarkers in exhaled breath condensate indicate presence and severity of cystic fibrosis in children
    Charlotte M H H T Robroeks
    Department of Paediatric Pulmonology, University Hospital Maastricht, Maastricht, The Netherlands
    Pediatr Allergy Immunol 19:652-9. 2008
    ..Longitudinal data are necessary to further confirm the role of these markers for the management of CF in children...
  5. doi Structural lung changes, lung function, and non-invasive inflammatory markers in cystic fibrosis
    Charlotte M H H T Robroeks
    Paediatric Pulmonology, University Hospital Maastricht, Maastricht, The Netherlands
    Pediatr Allergy Immunol 21:493-500. 2010
    ..Future longitudinal studies should reveal whether non-invasive monitoring of airway inflammation in CF adds to better follow-up of patients...
  6. doi Feasibility of exhaled nitric oxide measurements at various flow rates in children with asthma
    Charlotte M H H T Robroeks
    University Hospital Maastricht, Department of Paediatric Pulmonology, Maastricht, The Netherlands
    Pediatr Allergy Immunol 21:e222-8. 2010
    ..A significant learning effect was present. The long-term reproducibility of alveolar and bronchial NO values during 6 months was moderate...
  7. doi Impact of bacterial colonization on exhaled inflammatory markers in wheezing preschool children
    Kim D G van de Kant
    Department of Paediatric Pulmonology, School for Public Health and Primary Care CAPHRI, Maastricht University Medical Centre MUMC, PO Box 5800, 6202 AZ, Maastricht, The Netherlands
    J Breath Res 6:046001. 2012
    ..The various elevated exhaled inflammatory markers indicate increased airway inflammation in wheezing preschool children. In the presence of wheeze, we found no evidence for bacterial induced airway inflammation...
  8. doi Prevention of asthma in genetically susceptible children: a multifaceted intervention trial focussed on feasibility in general practice
    Tanja Maas
    Department of General Practice, Care and Public Health Research Institute, Maastricht University, Maastricht, The Netherlands
    Pediatr Allergy Immunol 22:794-802. 2011
    ..Although the effectiveness of the multifaceted allergen-reducing interventions for the prevention of asthma in susceptible children was showed to be proven, the feasibility was not clear...
  9. ncbi Childhood asthma: exhaled markers of airway inflammation, asthma control score, and lung function tests
    Philippe P R Rosias
    Department of Pediatric Pulmonology, University Hospital Maastricht, The Netherlands
    Pediatr Pulmonol 38:107-14. 2004
    ..To further evaluate the clinical utility of exhaled markers in monitoring childhood asthma, more studies are required on a wider range of asthma severity, and preferably with repeated measurements of markers and of asthma control...
  10. doi Elevated inflammatory markers at preschool age precede persistent wheezing at school age
    Kim D G van de Kant
    Department of Paediatric Pulmonology, School for Public Health and Primary Care, Maastricht University Medical Centre, Maastricht, The Netherlands
    Pediatr Allergy Immunol 23:259-64. 2012
    ....
  11. ncbi Free radicals in exhaled breath condensate in cystic fibrosis and healthy subjects
    Philippe P R Rosias
    Department of Pediatric Pulmonology, University Hospital of Maastricht, Maastricht, The Netherlands
    Free Radic Res 40:901-9. 2006
    ..Addition of hydrogen peroxide resulted in increased radical signal intensity. Detection of free radicals in EBC of children with CF and healthy subjects is feasible using EPR spectroscopy...
  12. doi Integrative genomic analysis identifies a role for intercellular adhesion molecule 1 in childhood asthma
    Ester M M Klaassen
    Department of Pediatric Pulmonology, School for Public Health and Primary Care CAPHRI, Maastricht University Medical Centre MUMC, Maastricht, The Netherlands
    Pediatr Allergy Immunol 25:166-72. 2014
    ..We aimed to employ an integrative genomic approach investigating inflammation markers on DNA, mRNA, and protein level at preschool age in relationship to asthma development...
  13. ncbi Interactive effect of family history and environmental factors on respiratory tract-related morbidity in infancy
    Sandra Kuiper
    Department of General Practice, Care and Public Health Research Institute, University of Maastricht, Maastricht, The Netherlands
    J Allergy Clin Immunol 120:388-95. 2007
    ..Family and environmental factors affect the development of respiratory morbidity. How these factors interact is unclear...
  14. pmc Clinical use of exhaled volatile organic compounds in pulmonary diseases: a systematic review
    Kim D G van de Kant
    Department of Pediatric Pulmonology, School for Public Health and Primary Care CAPHRI, Maastricht University Medical Center MUMC, P, O, Box 5800, 6202, AZ, Maastricht, The Netherlands
    Respir Res 13:117. 2012
    ..Despite these promising findings, multiple challenges such as further standardization and validation of the diverse techniques need to be mastered before VOCs can be applied into clinical practice...
  15. doi Exhaled breath profiling in diagnosing wheezy preschool children
    Kim D G van de Kant
    Dept of Paediatric Pulmonology, School for Public Health and Primary Care, Caphri, Maastricht University Medical Centre, Maastricht, The Netherlands
    Eur Respir J 41:183-8. 2013
    ..VOC profiles are able to distinguish children with and without recurrent wheeze with a reasonable accuracy. This proof of principle paves the way for additional research on VOCs in preschool wheezing...
  16. pmc A motivational interviewing intervention to PREvent PAssive Smoke Exposure (PREPASE) in children with a high risk of asthma: design of a randomised controlled trial
    Sasha G Hutchinson
    Department of Paediatric Pulmonology, Maastricht University Medical Centre MUMC CAPHRI School for Public Health and Primary Care, P O Box 616, Maastricht, MD 6200, The Netherlands
    BMC Public Health 13:177. 2013
    ..The aim of the PREPASE study is to test the effectiveness of such an intervention program towards eliminating or reducing of PS exposure in children at risk for asthma. This article describes the protocol of the PREPASE study...
  17. pmc Early diagnosis of asthma in young children by using non-invasive biomarkers of airway inflammation and early lung function measurements: study protocol of a case-control study
    Kim D G van de Kant
    Department of Paediatric Pulmonology, Maastricht University Medical Centre MUMC, Maastricht, The Netherlands
    BMC Public Health 9:210. 2009
    ..In addition, aetiological factors, including gene polymorphisms and gene expression profiles, in relation to the development of asthma are studied...
  18. pmc Multifactorial intervention for children with asthma and overweight (Mikado): study design of a randomised controlled trial
    Maartje Willeboordse
    Department of Paediatric Respiratory Medicine, School for Public Health and Primary Care CAPHRI, Maastricht University Medical Centre MUMC, P, Debyelaan 25, P, O, Box 5800, Maastricht, AZ, 6202, The Netherlands
    BMC Public Health 13:494. 2013
    ..In children this is hardly studied. The Mikado study aims to evaluate the effectiveness of a long term multifactorial weight reduction intervention, on asthma characteristics in children with asthma and a high body weight...
  19. ncbi Exhaled breath condensate in children: pearls and pitfalls
    Philippe P R Rosias
    Division of Paediatric Respiratory Medicine, Department of Paediatrics, University Hospital Maastricht, Maastricht, The Netherlands
    Pediatr Allergy Immunol 15:4-19. 2004
    ..Meanwhile, when using this technique or when interpreting research data, one should be fully aware of the possible methodological pitfalls...
  20. doi Actual asthma control in a paediatric outpatient clinic population: do patients perceive their actual level of control?
    Sanne C Hammer
    Department of Paediatric Pulmonology, University Hospital Maastricht, Maastricht, The Netherlands
    Pediatr Allergy Immunol 19:626-33. 2008
    ..Poorly controlled disease was related to several aspects of asthma management, which are potentially accessible for improvements...
  21. pmc Sex differences in the relationship between asthma and overweight in Dutch children: a survey study
    Maartje Willeboordse
    Department of Pediatric Respiratory Medicine, School for Public Health and Primary Care CAPHRI, Maastricht University Medical Center MUMC, Maastricht, The Netherlands
    PLoS ONE 8:e77574. 2013
    ..The aim of this study is to clarify the association between asthma and Body Mass Index (BMI) in children and whether this association is influenced by sex...
  22. pmc Structuring and validating a cost-effectiveness model of primary asthma prevention amongst children
    G Feljandro P Ramos
    Department of General Practice, CAPHRI School for Public Health and Primary Care, Maastricht University, Maastricht, The Netherlands
    BMC Med Res Methodol 11:150. 2011
    ..In this paper, we describe a procedure to structure and validate a model for the primary prevention of asthma in children...
  23. ncbi Chronic bronchiolitis in a 5-yr-old child after exposure to sulphur mustard gas
    E Dompeling
    Dept of Paediatric Pulmonology, University Hospital Maastricht, The Netherlands
    Eur Respir J 23:343-6. 2004
    ..Infectious exacerbations of the child's lung disease occurred. High resolution computed tomography scan showed multiple bronchiectasis. The histological picture of an open lung biopsy was best described as a "chronic bronchiolitis"...
  24. ncbi Breath condenser coatings affect measurement of biomarkers in exhaled breath condensate
    P P Rosias
    Dept of Paediatric Pulmonology, University Hospital Maastricht, Maastricht, The Netherlands
    Eur Respir J 28:1036-41. 2006
    ..Guidelines for exhaled breath condensate standardisation should include the most valid condenser coating to measure a specific biomarker...
  25. doi Increased cytokines, chemokines and soluble adhesion molecules in exhaled breath condensate of asthmatic children
    C M H H T Robroeks
    Department of Paediatric Pulmonology, Maastricht University Medical Centre, Maastricht, The Netherlands
    Clin Exp Allergy 40:77-84. 2010
    ..However, the use of a glass condenser system combined with a sensitive analytical technique may increase the possibility to assess these biomarkers in EBC in a reliable way...
  26. doi Biomarker reproducibility in exhaled breath condensate collected with different condensers
    P P Rosias
    Dept of Paediatric Pulmonology, Caphri Research Institute, University Hospital Maastricht, PO Box 5800, 6202 AZ Maastricht, The Netherlands
    Eur Respir J 31:934-42. 2008
    ..However, biomarker reproducibility in exhaled breath condensate in healthy adults was not influenced by the type of condenser...
  27. doi Mode and place of delivery, gastrointestinal microbiota, and their influence on asthma and atopy
    Frederika A van Nimwegen
    Department of Epidemiology, CAPHRI School for Public Health and Primary Care, Maastricht University Medical Centre, Maastricht, The Netherlands
    J Allergy Clin Immunol 128:948-55.e1-3. 2011
    ..However, results are inconsistent, and the hypothesized intermediate role of the microbiota in the association between birth mode and atopic manifestations has not been studied yet...
  28. doi Volatile organic compounds in exhaled breath as a diagnostic tool for asthma in children
    J W Dallinga
    Department of Health Risk Analysis and Toxicology, Nutrition and Toxicology Research Institute Maastricht, Maastricht University, Maastricht, The Netherlands
    Clin Exp Allergy 40:68-76. 2010
    ..The correct diagnosis of asthma in young children is often hard to achieve, resulting in undertreatment of asthmatic children and overtreatment in transient wheezers...
  29. ncbi Diplopia and strabismus convergens mimicking symptoms of tuberculous meningitis as side-effects of isoniazid
    Edward Dompeling
    Department of Paediatric Pulmonology, University Hospital of Maastricht, Maastricht, The Netherlands
    Eur J Pediatr 163:503-4. 2004
  30. pmc A systematic review of CD14 and toll-like receptors in relation to asthma in Caucasian children
    Ester MM Klaassen
    Department of Paediatric Pulmonology, School for Public Health and Primary Care CAPHRI, Maastricht University Medical Centre MUMC, P, O, Box 5800, Maastricht, 6202 AZ, The Netherlands
    Allergy Asthma Clin Immunol 9:10. 2013
    ..Future studies should include haplotype analysis and take environmental factors into account to further clarify the role of CD14 and toll-like receptors on childhood asthma...
  31. ncbi The primary prevention of asthma in children study: design of a multifaceted prevention program
    Sandra Kuiper
    Department of General Practice, Care and Public Health Research Institute, University of Maastricht, Maastricht, The Netherlands
    Pediatr Allergy Immunol 16:321-31. 2005
    ..Of these 92 infants, 45 (20 boys) were allocated to an intervention group and 47 (24 boys) to a control group. Until now all infants have been followed for at least 1 yr...
  32. ncbi Environmental exposure reduction in high-risk newborns: where do we start?
    Hubert J A M Schönberger
    Department of Family Practice, Research Institute ExTra, University Maastricht, Maastricht, The Netherlands
    Ann Allergy Asthma Immunol 91:531-8. 2003
    ....
  33. ncbi Association between first-degree familial predisposition of asthma and atopy (total IgE) in newborns
    S Kuiper
    Department of General Practice, University Hospital Maastricht, Maastricht, The Netherlands
    Clin Exp Allergy 36:594-601. 2006
    ..It is generally thought that infants with a first-degree familial predisposition of asthma are at higher risk of developing asthma than infants without predisposition...
  34. ncbi The PREVASC study: the clinical effect of a multifaceted educational intervention to prevent childhood asthma
    H J A M Schönberger
    Dept of General Practice, Research Institute Caphri, University Maastricht, Maastricht, The Netherlands
    Eur Respir J 25:660-70. 2005
    ..Follow-up is necessary to confirm whether the intervention can actually prevent the development of asthma...
  35. ncbi Compliance of asthmatic families with a primary prevention programme of asthma and effectiveness of measures to reduce inhalant allergens--a randomized trial
    H J A M Schönberger
    Department of General Practice, Research Institute Caphri, University Maastricht, Maastricht, The Netherlands
    Clin Exp Allergy 34:1024-31. 2004
    ..Compliance to and the effect of pre- and post-natal exposure reduction measures to prevent asthma in high-risk children from asthmatic families were studied...
  36. pmc Randomised controlled study of clinical efficacy of spacer therapy in asthma with regard to electrostatic charge
    E Dompeling
    Department of Paediatric Pulmonology, University Hospital Maastricht, P Debyelaan 25, PO Box 5800, 6202 AZ Maastricht, Netherlands
    Arch Dis Child 84:178-82. 2001
    ..Several laboratory studies found a clear negative influence of electrostatic charge (ESC) on plastic spacers on the delivery of aerosol...