Gerard Dijkstra

Summary

Affiliation: University Hospital Groningen
Country: The Netherlands

Publications

  1. ncbi request reprint Blockade of NF-kappaB activation and donation of nitric oxide: new treatment options in inflammatory bowel disease?
    G Dijkstra
    Dept of Gastroenterology and Hepatology, University Hospital Groningen, The Netherlands
    Scand J Gastroenterol Suppl . 2002
  2. ncbi request reprint Expression of nitric oxide synthases and formation of nitrotyrosine and reactive oxygen species in inflammatory bowel disease
    G Dijkstra
    Department of Gastroenterology and Hepatology, University Hospital Groningen, The Netherlands
    J Pathol 186:416-21. 1998
  3. ncbi request reprint Increased expression of inducible nitric oxide synthase in circulating monocytes from patients with active inflammatory bowel disease
    G Dijkstra
    Dept of Internal Medicine, University Hospital, Groningen, The Netherlands
    Scand J Gastroenterol 37:546-54. 2002
  4. ncbi request reprint Targeting nitric oxide in the gastrointestinal tract
    Gerard Dijkstra
    Department of Gastroenterology and Hepatology, University Hospital Groningen, PO Box 30 001, 9700 RB Groningen, The Netherlands
    Curr Opin Investig Drugs 5:529-36. 2004
  5. ncbi request reprint Opposite effect of oxidative stress on inducible nitric oxide synthase and haem oxygenase-1 expression in intestinal inflammation: anti-inflammatory effect of carbon monoxide
    Gerard Dijkstra
    Department of Gastroenterology and Hepatology, University Hospital Groningen, The Netherlands
    J Pathol 204:296-303. 2004
  6. doi request reprint Runt-related transcription factor 3 is associated with ulcerative colitis and shows epistasis with solute carrier family 22, members 4 and 5
    Rinse K Weersma
    Department of Gastroenterology and Hepatology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    Inflamm Bowel Dis 14:1615-22. 2008
  7. doi request reprint Confirmation of multiple Crohn's disease susceptibility loci in a large Dutch-Belgian cohort
    Rinse K Weersma
    Department of Gastroenterology and Hepatology, University Medical Center Groningen, University of Groningen, The Netherlands
    Am J Gastroenterol 104:630-8. 2009
  8. doi request reprint Differences in genetic background between active smokers, passive smokers, and non-smokers with Crohn's disease
    Frans van der Heide
    Department of Gastroenterology and Hepatology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    Am J Gastroenterol 105:1165-72. 2010
  9. doi request reprint Up-regulation and cytoprotective role of epithelial multidrug resistance-associated protein 1 in inflammatory bowel disease
    Hans Blokzijl
    Department of Gastroenterology and Hepatology, University Medical Center Groningen, University of Groningen, 9700 RB, Groningen, The Netherlands
    J Biol Chem 283:35630-7. 2008
  10. doi request reprint Genetic analysis in a Dutch study sample identifies more ulcerative colitis susceptibility loci and shows their additive role in disease risk
    Eleonora A M Festen
    Department of Gastroenterology and Hepatology, University Medical Centre Groningen, University of Groningen, Groningen, The Netherlands
    Am J Gastroenterol 105:395-402. 2010

Detail Information

Publications56

  1. ncbi request reprint Blockade of NF-kappaB activation and donation of nitric oxide: new treatment options in inflammatory bowel disease?
    G Dijkstra
    Dept of Gastroenterology and Hepatology, University Hospital Groningen, The Netherlands
    Scand J Gastroenterol Suppl . 2002
    ..However, NF-kappaB regulated genes like inducible nitric oxide synthase (iNOS) are also involved in cell survival mechanisms...
  2. ncbi request reprint Expression of nitric oxide synthases and formation of nitrotyrosine and reactive oxygen species in inflammatory bowel disease
    G Dijkstra
    Department of Gastroenterology and Hepatology, University Hospital Groningen, The Netherlands
    J Pathol 186:416-21. 1998
    ..One may speculate that NO has a protective role when during active inflammation other mucosal defence systems are impaired...
  3. ncbi request reprint Increased expression of inducible nitric oxide synthase in circulating monocytes from patients with active inflammatory bowel disease
    G Dijkstra
    Dept of Internal Medicine, University Hospital, Groningen, The Netherlands
    Scand J Gastroenterol 37:546-54. 2002
    ..In view of the possible role of NO in monocyte function, we also studied iNOS expression in relation to markers of monocyte activation...
  4. ncbi request reprint Targeting nitric oxide in the gastrointestinal tract
    Gerard Dijkstra
    Department of Gastroenterology and Hepatology, University Hospital Groningen, PO Box 30 001, 9700 RB Groningen, The Netherlands
    Curr Opin Investig Drugs 5:529-36. 2004
    ..Lumenal donation of NO could therefore block NFkappaB activation and be a treatment option in inflammatory conditions of the bowel...
  5. ncbi request reprint Opposite effect of oxidative stress on inducible nitric oxide synthase and haem oxygenase-1 expression in intestinal inflammation: anti-inflammatory effect of carbon monoxide
    Gerard Dijkstra
    Department of Gastroenterology and Hepatology, University Hospital Groningen, The Netherlands
    J Pathol 204:296-303. 2004
    ..These findings suggest that iNOS (NF-kappaB driven) and HO-1 (AP-1 driven) represent mutually exclusive survival mechanisms in intestinal epithelial cells...
  6. doi request reprint Runt-related transcription factor 3 is associated with ulcerative colitis and shows epistasis with solute carrier family 22, members 4 and 5
    Rinse K Weersma
    Department of Gastroenterology and Hepatology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    Inflamm Bowel Dis 14:1615-22. 2008
    ..We studied the association of RUNX3 in a cohort of IBD patients and analyzed the interaction with SLC22A4/5. RUNX3 and OCTN1 mRNA expression was assessed in inflamed and noninflamed mucosa from patients and controls...
  7. doi request reprint Confirmation of multiple Crohn's disease susceptibility loci in a large Dutch-Belgian cohort
    Rinse K Weersma
    Department of Gastroenterology and Hepatology, University Medical Center Groningen, University of Groningen, The Netherlands
    Am J Gastroenterol 104:630-8. 2009
    ..A genome-wide association scan by the Wellcome Trust Case Control Consortium (WTCCC) recently identified several novel susceptibility loci...
  8. doi request reprint Differences in genetic background between active smokers, passive smokers, and non-smokers with Crohn's disease
    Frans van der Heide
    Department of Gastroenterology and Hepatology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    Am J Gastroenterol 105:1165-72. 2010
    ..We studied allelic associations of 19 confirmed variants located in 14 CD-associated genes or loci, in CD patients stratified for active smoking at diagnosis and passive smoking in childhood...
  9. doi request reprint Up-regulation and cytoprotective role of epithelial multidrug resistance-associated protein 1 in inflammatory bowel disease
    Hans Blokzijl
    Department of Gastroenterology and Hepatology, University Medical Center Groningen, University of Groningen, 9700 RB, Groningen, The Netherlands
    J Biol Chem 283:35630-7. 2008
    ..These data show that MRP1 protects intestinal epithelial cells against inflammation-induced apoptotic cell death and provides a functional role for MRP1 in the inflamed intestinal epithelium of IBD patients...
  10. doi request reprint Genetic analysis in a Dutch study sample identifies more ulcerative colitis susceptibility loci and shows their additive role in disease risk
    Eleonora A M Festen
    Department of Gastroenterology and Hepatology, University Medical Centre Groningen, University of Groningen, Groningen, The Netherlands
    Am J Gastroenterol 105:395-402. 2010
    ..Genetic susceptibility is known to make a major contribution to the pathogenesis of ulcerative colitis (UC). Recently, three studies, including a genome-wide association study (GWAS), reported novel UC risk loci...
  11. ncbi request reprint Association of interleukin-1 receptor-associated kinase M (IRAK-M) and inflammatory bowel diseases
    Rinse K Weersma
    Department of Gastroenterology and Hepatology, University Medical Center Groningen and University of Groningen, Groningen, The Netherlands
    Scand J Gastroenterol 42:827-33. 2007
    ..IRAK-M is situated on chromosome 12q14, a susceptibility locus for IBD, which makes it a good candidate gene. The objective of the study was to analyze a large cohort of IBD patients for the association between IBD and IRAK-M...
  12. ncbi request reprint ATG16L1 and IL23R are associated with inflammatory bowel diseases but not with celiac disease in the Netherlands
    Rinse K Weersma
    Department of Gastroenterology and Hepatology, University Medical Center Groningen, The Netherlands
    Am J Gastroenterol 103:621-7. 2008
    ..We performed a case-control study for the association of IBD with IL23R and ATG16L1 in a Dutch cohort. We also looked at the association of IL23R and ATG16L1 with celiac disease...
  13. pmc Evolution of Costs of Inflammatory Bowel Disease over Two Years of Follow-Up
    Mirthe E van der Valk
    Department of Gastroenterology and Hepatology, University Medical Centre Utrecht, Utrecht, The Netherlands
    PLoS ONE 11:e0142481. 2016
    ..We aimed to explore the evolution of IBD-related costs over two years of follow-up...
  14. doi request reprint Prior colorectal neoplasia is associated with increased risk of ileoanal pouch neoplasia in patients with inflammatory bowel disease
    Lauranne A A P Derikx
    Inflammatory Bowel Disease Center, Department of Gastroenterology and Hepatology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Gastroenterology 146:119-28.e1. 2014
    ..We aimed to determine the cumulative incidence of pouch neoplasia in patients with IBD and identify risk factors for developing pouch neoplasia...
  15. doi request reprint Interplay of host genetics and gut microbiota underlying the onset and clinical presentation of inflammatory bowel disease
    Floris Imhann
    Department of Gastroenterology and Hepatology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands
    Gut . 2016
    ..Therefore, we performed a case-control analysis of the gut microbiota, the host genome and the clinical phenotypes of IBD...
  16. doi request reprint Comparison of Costs and Quality of Life in Ulcerative Colitis Patients with an Ileal Pouch-Anal Anastomosis, Ileostomy and Anti-TNFα Therapy
    Mirthe E van der Valk
    Department of Gastroenterology and Hepatology, University Medical Centre Utrecht, Utrecht, The Netherlands
    J Crohns Colitis 9:1016-23. 2015
    ..We compared the costs and quality of life of UC patients with a pouch reconstruction, an ileostomy or anti-tumour necrosis factor α (TNFα) therapy...
  17. doi request reprint Self-reported disability in patients with inflammatory bowel disease largely determined by disease activity and illness perceptions
    Mike van der Have
    1Department of Gastroenterology and Hepatology, University Medical Center Utrecht, the Netherlands 2Medical Psychology Section, Leiden University Medical Center, Leiden, the Netherlands 3Department of Gastroenterology and Hepatology, VU University Medical Center, Amsterdam, the Netherlands 4Department of Gastroenterology and Hepatology, Orbis Medical Center, Sittard, the Netherlands 5Department of Gastroenterology and Hepatology, University Medical Center Groningen, Groningen, the Netherlands 6University of Groningen, Groningen, the Netherlands 7Department of Gastroenterology and Hepatology, Radboud University Nijmegen Medical Center, Nijmegen, the Netherlands 8Division of Gastroenterology and Hepatology, Maastricht University Medical Center, Maastricht, the Netherlands 9Department of Gastroenterology and Hepatology, Academic Medical Center, Amsterdam, the Netherlands 10Department of Gastroenterology and Hepatology, Leiden University Medical Center, Leiden, the Netherlands 11Department of Gastroenterology and Hepatology, Erasmus University Medical Center, Rotterdam, the Netherlands 12Department of Gastroenterology and Hepatology, Slingeland Hospital, Doetinchem, the Netherlands 13Department of Gastroenterology and Hepatology, Diaconessenhuis, Leiden, the Netherlands 14Department of Gastroenterology and Hepatology, Onze Lieve Vrouwe Gasthuis, Amsterdam, the Netherlands 15Department of Gastroenterology and Hepatology, College of Pharmacy
    Inflamm Bowel Dis 21:369-77. 2015
    ..We assessed factors related to self-reported disability and the relationship between disability and direct health care costs...
  18. doi request reprint Risk factors of work disability in patients with inflammatory bowel disease--a Dutch nationwide web-based survey: work disability in inflammatory bowel disease
    Mirthe E van der Valk
    Department of Gastroenterology and Hepatology, University Medical Centre Utrecht, Utrecht, The Netherlands
    J Crohns Colitis 8:590-7. 2014
    ..Inflammatory bowel disease (IBD) is associated with high costs to society. Few data on the impact of IBD on work disability and potential predictive factors are available...
  19. ncbi request reprint Decreased P-glycoprotein (P-gp/MDR1) expression in inflamed human intestinal epithelium is independent of PXR protein levels
    Hans Blokzijl
    Department of Gastroenterology and Hepatology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    Inflamm Bowel Dis 13:710-20. 2007
    ..Here we compared intestinal MDR1 mRNA and protein expression in uninflamed and inflamed intestinal epithelium (IE) of patients with gastrointestinal inflammatory disorders to healthy controls...
  20. doi request reprint Active and passive smoking behaviour and cessation plans of patients with Crohn's disease and ulcerative colitis
    Frans van der Heide
    Department of Gastroenterology and Hepatology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    J Crohns Colitis 4:125-31. 2010
    ..This makes different changes in smoking behaviour after diagnosis between CD and UC likely. Changes in active smoking, cessation plans and passive smoking were studied in IBD patients...
  21. pmc Pooled Resequencing of 122 Ulcerative Colitis Genes in a Large Dutch Cohort Suggests Population-Specific Associations of Rare Variants in MUC2
    Marijn C Visschedijk
    Department of Gastroenterology and Hepatology, University of Groningen, University Medical Centre Groningen, 9700 RB, Groningen, The Netherlands
    PLoS ONE 11:e0159609. 2016
    ..In conclusion, this study has identified a putative role for MUC2 on UC susceptibility in the Dutch population and suggests a population-specific contribution of rare variants to UC. ..
  22. doi request reprint Intrauterine exposure and pharmacology of conventional thiopurine therapy in pregnant patients with inflammatory bowel disease
    Bindia Jharap
    Department of Gastroenterology and Hepatology, VU University Medical Center, Amsterdam, The Netherlands
    Gut 63:451-7. 2014
    ..We performed a study in pregnant patients with IBD who were using thiopurines, in order to determine the influence of pregnancy on thiopurine metabolism and to assess intrauterine exposure of the fetus to thiopurines...
  23. doi request reprint Healthcare costs of inflammatory bowel disease have shifted from hospitalisation and surgery towards anti-TNFα therapy: results from the COIN study
    Mirthe Emilie van der Valk
    Department of Gastroenterology and Hepatology, University Medical Centre Utrecht, Utrecht, The Netherlands
    Gut 63:72-9. 2014
    ..We aimed to assess the healthcare costs and productivity losses in a large cohort of IBD patients...
  24. doi request reprint Effects of active and passive smoking on disease course of Crohn's disease and ulcerative colitis
    Frans van der Heide
    Department of Gastroenterology and Hepatology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    Inflamm Bowel Dis 15:1199-207. 2009
    ..We studied the effects of active and passive smoking in Dutch IBD patients...
  25. doi request reprint Effects of active and passive smoking on Crohn's disease and ulcerative colitis in a cohort from a regional hospital
    Frans van der Heide
    Department of Gastroenterology and Hepatology, University Medical Center Groningen, University of Groningen, The Netherlands
    Eur J Gastroenterol Hepatol 23:255-61. 2011
    ..Earlier, we studied the effects of active and passive smoking in CD and UC patients from a university hospital. This study was conducted to assess the same effects in patients from a regional hospital...
  26. doi request reprint Thiopurines are associated with a reduction in surgical re-resections in patients with Crohn's disease: a long-term follow-up study in a regional and academic cohort
    Ellen S van Loo
    Department of Surgery, University Medical Center Groningen, Groningen, the Netherlands Department of Surgery, Scheper Ziekenhuis, Emmen, The Netherlands Department of Gastroenterology and Hepatology, University Medical Center Groningen, Groningen, the Netherlands Wenckebach Institute, Post Graduate School of Medicine, University Medical Center Groningen, Groningen, the Netherlands Departments of Surgery, and Gastroenterology, Medical Center Leeuwarden, Leeuwarden, The Netherlands and Department of Surgery, Isala Klinieken, Zwolle, The Netherlands
    Inflamm Bowel Dis 19:2801-8. 2013
    ..Therefore, we analyzed which factors were involved in surgical recurrence of CD in a large cohort of patients with CD operated in a regional and a university hospital...
  27. doi request reprint Westernized high-fat diet accelerates weight loss in dextran sulfate sodium-induced colitis in mice, which is further aggravated by supplementation of heme
    Elise M J van der Logt
    Department of Gastroenterology and Hepatology, University Medical Center Groningen, Hanzeplein 1, 9700 RB Groningen, The Netherlands
    J Nutr Biochem 24:1159-65. 2013
    ..Our data warrant a detailed analysis of the association of (red) meat-containing diets and the development of IBD...
  28. doi request reprint Malignant transformation of perianal and enterocutaneous fistulas is rare: results of 17 years of follow-up from The Netherlands
    Judith E Baars
    Department of Gastroenterology and Hepatology, Erasmus Medical Center, Gravendijkwal 230, Rotterdam, The Netherlands
    Scand J Gastroenterol 46:319-25. 2011
    ..We investigated adenocarcinoma originating from perianal and enterocutaneous fistulas in both CD patients and non-CD patients from nine large, mostly tertiary referral, hospitals in The Netherlands...
  29. doi request reprint The role of gut microbiota in health and disease: In vitro modeling of host-microbe interactions at the aerobe-anaerobe interphase of the human gut
    Julius Z H von Martels
    Department of Gastroenterology and Hepatology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands Electronic address
    Anaerobe . 2017
    ..This review discusses the role of gut microbiota in health and disease and gives an overview of the characteristics and applications of these novel host-microbe co-culture systems...
  30. doi request reprint Predicting Endoscopic Disease Activity in Crohn's Disease: A New and Validated Noninvasive Disease Activity Index (The Utrecht Activity Index)
    Itta M Minderhoud
    Department of Internal Medicine and Gastroenterology, Tergooi Hospital, Hilversum, the Netherlands Center for Medical Decision Making, Department of Public Health, Erasmus Medical Center Rotterdam, Rotterdam, The Netherlands Department of Gastroenterology, VU Medical Center, Amsterdam, The Netherlands Department of Gastroenterology, Erasmus Medical Center Rotterdam, Rotterdam, the Netherlands Center for Inflammatory Bowel Diseases, UCLA Health System, Los Angeles, California Department of Gastroenterology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands Department of Gastroenterology, University Medical Center Utrecht, Utrecht, the Netherlands and Department of Gastroenterology, Meander Medical Center, Amersfoort, The Netherlands
    Inflamm Bowel Dis 21:2453-9. 2015
    ....
  31. doi request reprint HSPA6 is an ulcerative colitis susceptibility factor that is induced by cigarette smoke and protects intestinal epithelial cells by stabilizing anti-apoptotic Bcl-XL
    Anouk Regeling
    Department of Gastroenterology and Hepatology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands Electronic address
    Biochim Biophys Acta 1862:788-96. 2016
    ..Here, we performed transcriptome profiling of cigarette smoke extract (CSE)-exposed DLD-1 and Jurkat cells (T-lymphocytes) and related this to UC susceptibility genes with protective functions in the intestinal epithelium...
  32. pmc Gastrointestinal pH and Transit Time Profiling in Healthy Volunteers Using the IntelliCap System Confirms Ileo-Colonic Release of ColoPulse Tablets
    Jacoba M Maurer
    University of Groningen, University Medical Center Groningen, Department of Clinical Pharmacy and Pharmacology, Groningen, The Netherlands
    PLoS ONE 10:e0129076. 2015
    ..This information will complete the in vivo release-profile of ColoPulse tablets...
  33. pmc A simple coculture system shows mutualism between anaerobic faecalibacteria and epithelial Caco-2 cells
    Mehdi Sadaghian Sadabad
    Departments of Medical Microbiology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands
    Sci Rep 5:17906. 2015
    ....
  34. doi request reprint The ATG16L1-T300A allele impairs clearance of pathosymbionts in the inflamed ileal mucosa of Crohn's disease patients
    Mehdi Sadaghian Sadabad
    Department of Gastroenterology and Hepatology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands Department of Medical Microbiology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands
    Gut 64:1546-52. 2015
    ..We investigated the effect of inflammation on the composition of microbiota in the ileal mucosa of CD patients in relation to the ATG16L1 risk status...
  35. doi request reprint Adenomas in patients with inflammatory bowel disease are associated with an increased risk of advanced neoplasia
    Fiona D M van Schaik
    Department of Gastroenterology and Hepatology, University Medical Center Utrecht, Utrecht, The Netherlands
    Inflamm Bowel Dis 19:342-9. 2013
    ..We compared the risk of advanced neoplasia (AN, defined as HGD or CRC) in IBD patients with adenomas to IBD patients without adenomas and patients without IBD with adenomas...
  36. pmc Impact of human granulocyte and monocyte isolation procedures on functional studies
    Lu Zhou
    Department of Gastroenterology and Hepatology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    Clin Vaccine Immunol 19:1065-74. 2012
    ....
  37. doi request reprint Diffuse enteritis after colectomy for ulcerative colitis: two case reports and review of the literature
    Sietske Corporaal
    Department of Gastroenterology and Hepatology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    Eur J Gastroenterol Hepatol 21:710-5. 2009
    ..The majority typically presented shortly after colectomy and responded well to steroids. The pathogenesis of this enteritis is unknown, but seems to be distinct from Crohn's disease and may be associated with UC and colectomy...
  38. doi request reprint Evidence for local expansion of IgA plasma cell precursors in human ileum
    Saravanan Yuvaraj
    Department of Cell Biology, Section Immunology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    J Immunol 183:4871-8. 2009
    ..A second wave of expansion of IgA-committed cells occurs locally within the lamina propria as evidenced by the high frequency of clonally related cells...
  39. ncbi request reprint Synthesis and evaluation of a fluorine-18 labeled antisense oligonucleotide as a potential PET tracer for iNOS mRNA expression
    Erik F J de Vries
    PET Center, Groningen University Hospital, P O Box 30 001, 9700 RB Groningen, The Netherlands
    Nucl Med Biol 31:605-12. 2004
    ..However, neither uptake nor efflux showed any selectivity for iNOS expressing cells. The oligonucleotide showed a high level of non-specific binding, which may have obscured its specific hybridization to iNOS mRNA...
  40. doi request reprint Human scFv SIgA expressed on Lactococcus lactis as a vector for the treatment of mucosal disease
    Saravanan Yuvaraj
    Department of Cell Biology, Section Immunology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    Mol Nutr Food Res 52:913-20. 2008
    ..Expression of specific antibodies on bacteria may allow local delivery of anticancer agents produced by such bacteria in conjunction with the antibody and provides a new avenue in the quest for targeted drug delivery...
  41. ncbi request reprint Absence of association between the multidrug resistance (MDR1) gene and inflammatory bowel disease
    Liekele E Oostenbrug
    Department of Gastroenterology and Hepatology, University Medical Center Groningen, University of Groningen, The Netherlands
    Scand J Gastroenterol 41:1174-82. 2006
    ..The purpose of this study was to examine the involvement of this gene in IBD in a large population of Dutch patients with IBD and family-based controls...
  42. doi request reprint Reduced ischemia-reoxygenation injury in rat intestine after luminal preservation with a tailored solution
    Anne Margot Roskott
    Department of Surgery, University Medical Center Groningen, Groningen, The Netherlands
    Transplantation 90:622-9. 2010
    ..This study was designed to test the effects of luminal preservation with an alternative preservation solution in addition to the common vascular flush with UW solution on graft viability after preservation and ex vivo reoxygenation...
  43. ncbi request reprint Early bacterial dependent induction of inducible nitric oxide synthase (iNOS) in epithelial cells upon transfer of CD45RB(high) CD4(+) T cells in a model for experimental colitis
    Gerard Dijkstra
    Department of Gastroenterology and Hepatology, University of Groningen, University Medical Center Groningen, The Netherlands
    Inflamm Bowel Dis 13:1467-74. 2007
    ..Both the role of inducible nitric oxide synthase (iNOS) in the development of inflammatory bowel disease (IBD) as well as the molecular details governing its mucosal induction remain unclear...
  44. doi request reprint Smoking behavior in liver transplant recipients
    Frans van der Heide
    Department of Gastroenterology and Hepatology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    Liver Transpl 15:648-55. 2009
    ..In conclusion, smoking is a serious problem after OLT and increases the risk for malignancy. Prevention programs should focus not only on active smokers but also on former smokers...
  45. pmc Proton pump inhibitors affect the gut microbiome
    Floris Imhann
    University of Groningen and University Medical Center Groningen, Department of Gastroenterology and Hepatology, Groningen, The Netherlands
    Gut 65:740-8. 2016
    ..The gut microbiome plays an important role in enteric infections, by resisting or promoting colonisation by pathogens. In this study, we investigated the influence of PPI use on the gut microbiome...
  46. doi request reprint Ulcerative colitis patients with an inflammatory response upon mesalazine cannot be desensitized: a randomized study
    Dorien J Buurman
    Department of Gastroenterology and Hepatology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    Scand J Gastroenterol 50:399-405. 2015
    ....
  47. doi request reprint Adalimumab and infliximab are equally effective for Crohn's disease in patients not previously treated with anti-tumor necrosis factor-α agents
    Christine Kestens
    Department of Gastroenterology and Hepatology, University Medical Center Utrecht, The Netherlands
    Clin Gastroenterol Hepatol 11:826-31. 2013
    ..We compared the effectiveness and safety of IFX and ADA in carefully matched cohorts...
  48. ncbi request reprint Matrix metalloproteinases as profibrotic factors in terminal ileum in Crohn's disease
    Nienke Warnaar
    Department of Surgery, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    Inflamm Bowel Dis 12:863-9. 2006
    ..This study analyzes spatial expression of MMP-1, MMP-3, MMP-9, tissue inhibitor of MMP-1, and collagen III to get better insight in tissue remodeling of terminal ileum of CD patients...
  49. doi request reprint The genetic background of inflammatory bowel disease: from correlation to causality
    Werna Tc Uniken Venema
    Department of Gastroenterology and Hepatology, University of Groningen and University Medical Center Groningen, Groningen, The Netherlands
    J Pathol . 2016
    ..Furthermore, we discuss the future role of genetics in unravelling disease mechanisms in IBD. Copyright © 2016 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd...
  50. doi request reprint Allogeneic Bone Marrow-Derived Mesenchymal Stromal Cells Promote Healing of Refractory Perianal Fistulas in Patients With Crohn's Disease
    Ilse Molendijk
    Department of Gastroenterology and Hepatology, Leiden University Medical Center, Leiden, The Netherlands
    Gastroenterology 149:918-27.e6. 2015
    ..We evaluated the effects of local administration of bone marrow-derived mesenchymal stromal cells (MSCs) to these patients from healthy donors in a double-blind, placebo-controlled study...
  51. pmc Performance of the Montreal classification for inflammatory bowel diseases
    Lieke M Spekhorst
    Lieke M Spekhorst, Marijn C Visschedijk, Rudi Alberts, Eleonora A Festen, Gerard Dijkstra, Rinse K Weersma, Department of Gastroenterology and Hepatology, University of Groningen and University Medical Centre Groningen, 9700 RB Groningen, The Netherlands
    World J Gastroenterol 20:15374-81. 2014
    ..To validate the Montreal classification system for Crohn's disease (CD) and ulcerative colitis (UC) within the Netherlands...
  52. doi request reprint Correlation of genetic risk and messenger RNA expression in a Th17/IL23 pathway analysis in inflammatory bowel disease
    Karin Fransen
    Departments of Genetics, and Gastroenterology and Hepatology, University Medical Centre Groningen, University of Groningen, Groningen, The Netherlands
    Inflamm Bowel Dis 20:777-82. 2014
    ..So far, it is unknown whether and how associated risk variants affect expression of the genes encoding for Th17/IL23 pathway proteins...
  53. doi request reprint A non-invasive, low-cost study design to determine the release profile of colon drug delivery systems: a feasibility study
    Marina J M Maurer
    Department of Hospital and Clinical Pharmacy, University Medical Center Groningen, University of Groningen, PO Box 30001, 9700 RB, Groningen, The Netherlands
    Pharm Res 29:2070-8. 2012
    ..We introduce an isotope dual-label approach ((13)C- and (15)N(2)-urea) for colon drug delivery systems that can be performed in a one-day, non-invasive study-design...
  54. ncbi request reprint Inflammatory bowel disease after liver transplantation: a role for cytomegalovirus infection
    Robert C Verdonk
    Department of Gastroenterology and Hepatology, University Medical Center Groningen, The Netherlands
    Scand J Gastroenterol 41:205-11. 2006
    ..Cytomegalovirus (CMV) infection has been suggested to play a role in the pathogenesis of IBD. The aim of this study was to investigate the role of CMV infection in the development of IBD after OLT...
  55. ncbi request reprint Relative contributions of NOS isoforms during experimental colitis: endothelial-derived NOS maintains mucosal integrity
    Bruce A Vallance
    Division of Gastroenterology, British Columbia s Children s Hospital, Vancouver, British Columbia, V6H 3V4
    Am J Physiol Gastrointest Liver Physiol 287:G865-74. 2004
    ..These results identify a protective role for both iNOS and eNOS during colitis, with eNOS deficiency resulting in impaired intestinal defense against lumenal bacteria and increased susceptibility to colitis...
  56. pmc Calprotectin: a novel noninvasive marker for intestinal allograft monitoring
    Debra Sudan
    Department of Transplant, University of Nebraska Medical Center, Omaha, NE 68198, USA
    Ann Surg 246:311-5. 2007
    ..To identify a noninvasive screening test for intestinal allograft monitoring...