Arjan Diepstra

Summary

Affiliation: University Medical Center Groningen
Country: The Netherlands

Publications

  1. doi request reprint Serum chemokine levels in Hodgkin lymphoma patients: highly increased levels of CCL17 and CCL22
    Marijke Niens
    Department of Medical Genetics, Unviersity Medical Centre Groningen, University of Groningen, Groningen, The Netherlands
    Br J Haematol 140:527-36. 2008
  2. pmc Epidemiology of classical Hodgkin lymphoma and its association with Epstein Barr virus in Northern China
    Xin Huang
    Department of Pathology and Medical Biology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    PLoS ONE 6:e21152. 2011
  3. ncbi request reprint HLA class II expression by Hodgkin Reed-Sternberg cells is an independent prognostic factor in classical Hodgkin's lymphoma
    Arjan Diepstra
    Department of Pathology and Laboratory Medicine, University Medical Center Groningen, University of Groningen, The Netherlands
    J Clin Oncol 25:3101-8. 2007
  4. ncbi request reprint Association with HLA class I in Epstein-Barr-virus-positive and with HLA class III in Epstein-Barr-virus-negative Hodgkin's lymphoma
    A Diepstra
    Department of Pathology, University Medical Centre Groningen, University of Groningen, Groningen, The Netherlands
    Lancet 365:2216-24. 2005
  5. doi request reprint HLA-G protein expression as a potential immune escape mechanism in classical Hodgkin's lymphoma
    A Diepstra
    Department of Pathology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    Tissue Antigens 71:219-26. 2008
  6. doi request reprint Latent Epstein-Barr virus infection of tumor cells in classical Hodgkin's lymphoma predicts adverse outcome in older adult patients
    Arjan Diepstra
    Department of Pathology and Medical Biology, University Medical Center Groningen, Hanzeplein 1, PO Box 30 001, 9700 RB Groningen, The Netherlands
    J Clin Oncol 27:3815-21. 2009
  7. pmc HLA associations in classical Hodgkin lymphoma: EBV status matters
    Xin Huang
    Department of Pathology and Medical Biology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands
    PLoS ONE 7:e39986. 2012
  8. pmc HLA-A*02:07 is a protective allele for EBV negative and a susceptibility allele for EBV positive classical Hodgkin lymphoma in China
    Xin Huang
    Department of Pathology and Medical Biology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands
    PLoS ONE 7:e31865. 2012
  9. pmc Expression of HLA class I and HLA class II by tumor cells in Chinese classical Hodgkin lymphoma patients
    Xin Huang
    Department of Pathology and Medical Biology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    PLoS ONE 5:e10865. 2010
  10. ncbi request reprint HLA-A*02 is associated with a reduced risk and HLA-A*01 with an increased risk of developing EBV+ Hodgkin lymphoma
    Marijke Niens
    Department of Genetics, University Medical Center Groningen, University of Groningen, 9700 RB Groningen, The Netherlands
    Blood 110:3310-5. 2007

Collaborators

Detail Information

Publications28

  1. doi request reprint Serum chemokine levels in Hodgkin lymphoma patients: highly increased levels of CCL17 and CCL22
    Marijke Niens
    Department of Medical Genetics, Unviersity Medical Centre Groningen, University of Groningen, Groningen, The Netherlands
    Br J Haematol 140:527-36. 2008
    ..CCL17 and CCL22 were the only chemokines with increased serum levels in the vast majority of HL patients, which provides further insight into the molecular mechanism(s) leading to infiltrations of reactive lymphocytes in HL...
  2. pmc Epidemiology of classical Hodgkin lymphoma and its association with Epstein Barr virus in Northern China
    Xin Huang
    Department of Pathology and Medical Biology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    PLoS ONE 6:e21152. 2011
    ..This is the first report on epidemiological features of cHL patients from Northern regions of China. These features are compared to data from a previously published Dutch cHL population...
  3. ncbi request reprint HLA class II expression by Hodgkin Reed-Sternberg cells is an independent prognostic factor in classical Hodgkin's lymphoma
    Arjan Diepstra
    Department of Pathology and Laboratory Medicine, University Medical Center Groningen, University of Groningen, The Netherlands
    J Clin Oncol 25:3101-8. 2007
    ..The neoplastic Hodgkin Reed-Sternberg (HRS) cells in classical Hodgkin's lymphoma (cHL) are derived from B cells. The frequency of HLA class II downregulation and its effect on prognosis are unknown...
  4. ncbi request reprint Association with HLA class I in Epstein-Barr-virus-positive and with HLA class III in Epstein-Barr-virus-negative Hodgkin's lymphoma
    A Diepstra
    Department of Pathology, University Medical Centre Groningen, University of Groningen, Groningen, The Netherlands
    Lancet 365:2216-24. 2005
    ..Because presentation of EBV antigenic peptides can elicit vigorous immune responses, we investigated associations of the HLA region with EBV-positive and EBV-negative Hodgkin's lymphoma...
  5. doi request reprint HLA-G protein expression as a potential immune escape mechanism in classical Hodgkin's lymphoma
    A Diepstra
    Department of Pathology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    Tissue Antigens 71:219-26. 2008
    ..Our results suggest that induction of HLA-G protein expression in HRS cells contributes to the modulation of immune responses observed in cHL...
  6. doi request reprint Latent Epstein-Barr virus infection of tumor cells in classical Hodgkin's lymphoma predicts adverse outcome in older adult patients
    Arjan Diepstra
    Department of Pathology and Medical Biology, University Medical Center Groningen, Hanzeplein 1, PO Box 30 001, 9700 RB Groningen, The Netherlands
    J Clin Oncol 27:3815-21. 2009
    ..In classical Hodgkin's lymphoma (cHL), the impact of tumor cell Epstein-Barr virus (EBV) status on clinical outcome is controversial...
  7. pmc HLA associations in classical Hodgkin lymphoma: EBV status matters
    Xin Huang
    Department of Pathology and Medical Biology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands
    PLoS ONE 7:e39986. 2012
    ..Furthermore several new protective and predisposing HLA class I and II associations for the EBV+, the EBV- and the entire cHL population were identified...
  8. pmc HLA-A*02:07 is a protective allele for EBV negative and a susceptibility allele for EBV positive classical Hodgkin lymphoma in China
    Xin Huang
    Department of Pathology and Medical Biology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands
    PLoS ONE 7:e31865. 2012
    ..028), EBV- cHL vs controls (p = 0.045) and EBV+ vs EBV- cHL cases (p = 2×10(-5)). In conclusion, HLA-A*02:07 is a predisposing allele for EBV+ cHL and a protective allele for EBV- cHL in the northern Chinese population...
  9. pmc Expression of HLA class I and HLA class II by tumor cells in Chinese classical Hodgkin lymphoma patients
    Xin Huang
    Department of Pathology and Medical Biology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    PLoS ONE 5:e10865. 2010
    ..HLA expression (in relation to EBV) in Asian cHL patients has not been previously investigated...
  10. ncbi request reprint HLA-A*02 is associated with a reduced risk and HLA-A*01 with an increased risk of developing EBV+ Hodgkin lymphoma
    Marijke Niens
    Department of Genetics, University Medical Center Groningen, University of Groningen, 9700 RB Groningen, The Netherlands
    Blood 110:3310-5. 2007
    ..It is known that HLA-A*02 can present EBV-derived peptides and can evoke an effective immune response, which may explain the protective phenotype...
  11. ncbi request reprint The human leukocyte antigen class I region is associated with EBV-positive Hodgkin's lymphoma: HLA-A and HLA complex group 9 are putative candidate genes
    Marijke Niens
    Department of Medical Genetics, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    Cancer Epidemiol Biomarkers Prev 15:2280-4. 2006
    ..HLA-A represents the most interesting target because of its consistent expression in EBV-positive Hodgkin's lymphoma cases and its ability to present EBV-derived peptides to cytotoxic T cells...
  12. pmc Low frequency of FAS mutations in Reed-Sternberg cells of Hodgkin's lymphoma
    Ewerton M Maggio
    Department of Pathology and Laboratory Medicine, University Medical Center Groningen, The Netherlands
    Am J Pathol 162:29-35. 2003
    ..Our data show that FAS mutations are rare and suggest that overexpression of c-FLIP, which was present in all cases, is involved in the resistance to FAS-mediated apoptosis...
  13. doi request reprint MiR-17/106b seed family regulates p21 in Hodgkin's lymphoma
    Johan H Gibcus
    Department of Pathology, Division of Pathology, University Medical Centre Groningen, University of Groningen, The Netherlands
    J Pathol 225:609-17. 2011
    ..Thus, in HL high miR-17/106b expression contributes to a dysfunctional p53 pathway and thereby also to the malignant phenotype...
  14. ncbi request reprint High expression of B-cell receptor inducible gene BIC in all subtypes of Hodgkin lymphoma
    Anke van den Berg
    Pathology and Laboratory Medicine, University Medical Center Groningen, Groningen, The Netherlands
    Genes Chromosomes Cancer 37:20-8. 2003
    ..In normal tissue, BIC is expressed weakly in a minority of germinal center B cells. Expression of BIC can be modified/influenced by BcR triggering, indicating that BIC might play a role in the selection of B cells...
  15. pmc PML nuclear bodies and SATB1 are associated with HLA class I expression in EBV+ Hodgkin lymphoma
    Yuxuan Liu
    Department of Pathology and Medical Biology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands
    PLoS ONE 8:e72930. 2013
    ..In conclusion, both PML and SATB1 are correlated to HLA class I expression levels in EBV+ cHL. ..
  16. pmc Expression of the c-Met oncogene by tumor cells predicts a favorable outcome in classical Hodgkin's lymphoma
    Chuanhui Xu
    Department of Pathology and Medical Biology, University Medical Center Groningen, PO Box 30 001, Hanzeplein 1, HPC EA10, 9700, RB Groningen, The Netherlands
    Haematologica 97:572-8. 2012
    ..We studied the function and prognostic significance of c-Met and hepatocyte growth factor protein expression in patients with classical Hodgkin's lymphoma...
  17. ncbi request reprint Global correlation of genome and transcriptome changes in classical Hodgkin lymphoma
    Joost Kluiver
    Department of Pathology and Laboratory Medicine, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    Hematol Oncol 25:21-9. 2007
    ..FSCN1 and IRAK1 mapping at genomic loci (7p and Xq) that frequently showed gain were overexpressed in cHL cell lines and might be involved in the pathogenesis of cHL...
  18. ncbi request reprint A factorial experiment for optimizing the PCR conditions in routine genotyping
    Marijke Niens
    Department of Medical Genetics, University Medical Center Groningen, Groningen, The Netherlands
    Biotechnol Appl Biochem 42:157-62. 2005
    ..However, the condition leading to the highest signals is not necessarily the best operational condition. The best operational condition is minimally sensitive to random pipetting fluctuations and yields reliable genotypes as well...
  19. doi request reprint Multiple HLA class I and II associations in classical Hodgkin lymphoma and EBV status defined subgroups
    Xin Huang
    Department of Pathology and Medical Biology, University Medical Center Groningen, University of Groningen, The Netherlands
    Blood 118:5211-7. 2011
    ..Furthermore, several new protective and predisposing HLA class I and II associations for the EBV(+), the EBV(-), and the entire cHL population were identified...
  20. pmc Plasma thymus and activation-regulated chemokine as an early response marker in classical Hodgkin's lymphoma
    Wouter J Plattel
    Department of Hematology, University of Groningen, University Medical Center Groningen, The Netherlands
    Haematologica 97:410-5. 2012
    ..To define its value as a marker to monitor treatment response, we correlated serial plasma thymus and activation-regulated chemokine levels with clinical response in newly diagnosed and relapsed classical Hodgkin's lymphoma patients...
  21. ncbi request reprint Clonal relation in a case of CLL, ALCL, and Hodgkin composite lymphoma
    Anke van den Berg
    Department of Pathology and Laboratory Medicine, University and University Hospital Groningen, Groningen, The Netherlands
    Blood 100:1425-9. 2002
    ..The findings indicate transformation of the CLL cells into a large cell lymphoma with anaplastic morphology and a Hodgkin component...
  22. ncbi request reprint Common and differential chemokine expression patterns in rs cells of NLP, EBV positive and negative classical Hodgkin lymphomas
    Ewerton M Maggio
    Department of Pathology and Laboratory Medicine, University Hospital Groningen, Groningen, The Netherlands
    Int J Cancer 99:665-72. 2002
    ..The results indicate that RS cells produce a complex pattern of chemokines that are involved in the recruitment of reactive cells and contribute to the paradox of an extensive but ineffective host immune response...
  23. pmc Insulin-like growth factor 1 receptor is a prognostic factor in classical Hodgkin lymphoma
    Zheng Liang
    Department of Pathology and Medical Biology, University of Groningen and University Medical Center Groningen, Groningen, Netherlands Laboratory of Cancer Cell Biology, Tianjin Medical University Cancer Institute and Hospital, Tianjin, China Department of Otolaryngology, Tianjin Medical University General Hospital, Tianjin, China
    PLoS ONE 9:e87474. 2014
    ..In conclusion, IGF-1R expression in HRS cells predicts a favorable outcome, despite the oncogenic effect of IGF-1R in cHL cell lines...
  24. ncbi request reprint Proteomics analysis of Hodgkin lymphoma: identification of new players involved in the cross-talk between HRS cells and infiltrating lymphocytes
    Yue Ma
    Department of Pathology and Laboratory Medicine, Centre for Medical Biomics, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    Blood 111:2339-46. 2008
    ..Proteomics analyses of HL cell line supernatant allowed detection of new secreted proteins, which may add to our insights in the interaction between HRS cells and infiltrating lymphocytes and in some instances might serve as biomarkers...
  25. doi request reprint miRNA profiling of B-cell subsets: specific miRNA profile for germinal center B cells with variation between centroblasts and centrocytes
    Lu Ping Tan
    Department of Pathology and Laboratory Medicine, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    Lab Invest 89:708-16. 2009
    ..In conclusion, miRNA profiles of naïve, GC and memory B cells were established and validated by miRNA ISH. Within the GC cells, a marked difference was observed between the light and the dark zone...
  26. doi request reprint The microenvironment in classical Hodgkin lymphoma: an actively shaped and essential tumor component
    Yuxuan Liu
    Department of Pathology and Medical Biology, University of Groningen, University Medical Center Groningen, Netherlands Electronic address
    Semin Cancer Biol 24:15-22. 2014
    ..In addition, the tumor cells produce immune suppressive cytokines that inhibit cytotoxic responses. In this review the relevance of the microenvironment in the pathogenesis of cHL will be discussed. ..
  27. ncbi request reprint Germline FAS gene mutation in a case of ALPS and NLP Hodgkin lymphoma
    Anke van den Berg
    Department of Pathology and Laboratory Medicine, University Hospital Groningen, The Netherlands
    Blood 99:1492-4. 2002
    ..Because ALPS and NLP HL are both highly infrequent conditions, the occurrence in at least 3 families suggests a causative relationship between germline FAS gene mutations and NLP HL...
  28. ncbi request reprint Chemokines, cytokines and their receptors in Hodgkin's lymphoma cell lines and tissues
    E Maggio
    Department of Pathology, University Hospital of Groningen, The Netherlands
    Ann Oncol 13:52-6. 2002
    ..These molecules with specific receptor affinities contribute, for example by attracting TH2-like T cells, to the maintenance of a favorable environment for survival of RS cells...