Eske M Derks

Summary

Affiliation: University Medical Center Utrecht
Country: The Netherlands

Publications

  1. pmc Kraepelin was right: a latent class analysis of symptom dimensions in patients and controls
    Eske M Derks
    Department of Psychiatry, Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, Heidelberglaan 100, 3584 CX Utrecht, The Netherlands
    Schizophr Bull 38:495-505. 2012
  2. doi Antipsychotic drug treatment in first-episode psychosis: should patients be switched to a different antipsychotic drug after 2, 4, or 6 weeks of nonresponse?
    Eske M Derks
    Rudolf Magnus Institute of Neuroscience, Department of Psychiatry, University Medical Centre Utrecht, Utrecht, The Netherlands
    J Clin Psychopharmacol 30:176-80. 2010
  3. pmc Investigation of the genetic association between quantitative measures of psychosis and schizophrenia: a polygenic risk score analysis
    Eske M Derks
    Department of Psychiatry, Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, The Netherlands
    PLoS ONE 7:e37852. 2012
  4. doi No evidence that common genetic risk variation is shared between schizophrenia and autism
    Jacob A S Vorstman
    Rudolf Magnus Institute of Neuroscience, Department of Psychiatry, University Medical Center Utrecht, Utrecht, The Netherlands
    Am J Med Genet B Neuropsychiatr Genet 162:55-60. 2013
  5. pmc Genetic schizophrenia risk variants jointly modulate total brain and white matter volume
    Afke F Terwisscha van Scheltinga
    Department of Psychiatry, Rudolf Magnus Institute of Neuroscience, University Medical Centre Utrecht, Utrecht
    Biol Psychiatry 73:525-31. 2013
  6. pmc The identification of family subtype based on the assessment of subclinical levels of psychosis in relatives
    Eske M Derks
    University Medical Center Utrecht, Department of Psychiatry, Rudolf Magnus Institute of Neuroscience, AMC APC, room PA1 179 Meibergdreef, Amsterdam, AZ 51105, The Netherlands
    BMC Psychiatry 12:71. 2012
  7. pmc The treatment of hallucinations in schizophrenia spectrum disorders
    Iris E C Sommer
    Neuroscience Division, Psychiatry Department, University Medical Centre Utrecht and Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, PO Box 85500, 3508 GA, Utrecht, The Netherlands
    Schizophr Bull 38:704-14. 2012
  8. pmc Assumptions and properties of limiting pathway models for analysis of epistasis in complex traits
    Sven Stringer
    Department of Psychiatry, Amsterdam Medical Center, Amsterdam, The Netherlands Department of Psychiatry, Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, Utrecht, The Netherlands Queensland Brain Institute, University of Queensland, Brisbane, Australia
    PLoS ONE 8:e68913. 2013
  9. pmc Focal and global brain measurements in siblings of patients with schizophrenia
    Heleen B M Boos
    Rudolf Magnus Institute of Neuroscience, Department of Psychiatry, University Medical Center Utrecht, The Netherlands
    Schizophr Bull 38:814-25. 2012
  10. pmc Segment-wise genome-wide association analysis identifies a candidate region associated with schizophrenia in three independent samples
    Thomas E Gladwin
    Department of Psychiatry, Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, Utrecht, The Netherlands
    PLoS ONE 7:e38828. 2012

Detail Information

Publications13

  1. pmc Kraepelin was right: a latent class analysis of symptom dimensions in patients and controls
    Eske M Derks
    Department of Psychiatry, Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, Heidelberglaan 100, 3584 CX Utrecht, The Netherlands
    Schizophr Bull 38:495-505. 2012
    ..In conclusion, symptom heterogeneity is more pronounced in bipolar disorder compared with schizophrenia. Reducing phenotypic heterogeneity within psychosis patients and controls may facilitate etiological research...
  2. doi Antipsychotic drug treatment in first-episode psychosis: should patients be switched to a different antipsychotic drug after 2, 4, or 6 weeks of nonresponse?
    Eske M Derks
    Rudolf Magnus Institute of Neuroscience, Department of Psychiatry, University Medical Centre Utrecht, Utrecht, The Netherlands
    J Clin Psychopharmacol 30:176-80. 2010
    ..However, as the increase in prediction accuracy is modest, it is uncertain whether this improvement is clinically relevant...
  3. pmc Investigation of the genetic association between quantitative measures of psychosis and schizophrenia: a polygenic risk score analysis
    Eske M Derks
    Department of Psychiatry, Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, The Netherlands
    PLoS ONE 7:e37852. 2012
    ..This does not necessarily imply that a genetic basis is nonexistent, but does suggest that it is distinct from the polygenic risk score for schizophrenia...
  4. doi No evidence that common genetic risk variation is shared between schizophrenia and autism
    Jacob A S Vorstman
    Rudolf Magnus Institute of Neuroscience, Department of Psychiatry, University Medical Center Utrecht, Utrecht, The Netherlands
    Am J Med Genet B Neuropsychiatr Genet 162:55-60. 2013
    ..These findings provide important novel insights into shared and distinct elements of the genetic architecture of autism and schizophrenia...
  5. pmc Genetic schizophrenia risk variants jointly modulate total brain and white matter volume
    Afke F Terwisscha van Scheltinga
    Department of Psychiatry, Rudolf Magnus Institute of Neuroscience, University Medical Centre Utrecht, Utrecht
    Biol Psychiatry 73:525-31. 2013
    ..It is likely that subsets of disease-associated SNPs are associated with distinct heritable disease-associated phenotypes. Therefore, we examined the shared genetic susceptibility modulating schizophrenia and brain volume...
  6. pmc The identification of family subtype based on the assessment of subclinical levels of psychosis in relatives
    Eske M Derks
    University Medical Center Utrecht, Department of Psychiatry, Rudolf Magnus Institute of Neuroscience, AMC APC, room PA1 179 Meibergdreef, Amsterdam, AZ 51105, The Netherlands
    BMC Psychiatry 12:71. 2012
    ..We will introduce a more refined method to distinguish between family subtypes based on psychosis dimension profiles in the relatives of schizophrenia patients...
  7. pmc The treatment of hallucinations in schizophrenia spectrum disorders
    Iris E C Sommer
    Neuroscience Division, Psychiatry Department, University Medical Centre Utrecht and Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, PO Box 85500, 3508 GA, Utrecht, The Netherlands
    Schizophr Bull 38:704-14. 2012
    ..Electroconvulsive therapy (ECT) is considered a last resort for treatment-resistant psychosis. Although several studies showed clinical improvement, a specific reduction in hallucination severity has never been demonstrated...
  8. pmc Assumptions and properties of limiting pathway models for analysis of epistasis in complex traits
    Sven Stringer
    Department of Psychiatry, Amsterdam Medical Center, Amsterdam, The Netherlands Department of Psychiatry, Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, Utrecht, The Netherlands Queensland Brain Institute, University of Queensland, Brisbane, Australia
    PLoS ONE 8:e68913. 2013
    ..Together with theoretical, empirical, and pragmatic arguments we conclude that in outbred populations the contribution of additive genetic variance is likely to be much more important than the contribution of non-additive variance. ..
  9. pmc Focal and global brain measurements in siblings of patients with schizophrenia
    Heleen B M Boos
    Rudolf Magnus Institute of Neuroscience, Department of Psychiatry, University Medical Center Utrecht, The Netherlands
    Schizophr Bull 38:814-25. 2012
    ..This large magnetic resonance imaging study examined brain structures in patients with schizophrenia, their nonpsychotic siblings, and healthy control subjects using global and focal brain measurements...
  10. pmc Segment-wise genome-wide association analysis identifies a candidate region associated with schizophrenia in three independent samples
    Thomas E Gladwin
    Department of Psychiatry, Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, Utrecht, The Netherlands
    PLoS ONE 7:e38828. 2012
    ..We conclude that considering relatively wide segments of chromosomes may reveal reliable relationships between the genome and schizophrenia, suggesting novel methodological possibilities as well as raising theoretical questions...
  11. pmc The relationship of DNA methylation with age, gender and genotype in twins and healthy controls
    Marco P Boks
    Rudolf Magnus Institute of Neuroscience, Department of Psychiatry, University Medical Center Utrecht, Utrecht, The Netherlands
    PLoS ONE 4:e6767. 2009
    ..The identification of CpG loci of which DNA methylation levels are under genetic control or are related to age or gender will facilitate further studies into the role of DNA methylation and disease...
  12. doi The influence of semantic top-down processing in auditory verbal hallucinations
    Kirstin Daalman
    Department of Psychiatry, Neuroscience Division, University Medical Center Utrecht and Rudolf Magnus Institute for Neuroscience, Heidelberglaan 100, 3584 CX Utrecht, The Netherlands
    Schizophr Res 139:82-6. 2012
    ..g., expectations), reducing the influence of bottom-up information coming from the sense organs. This bias predisposes to false perceptions, i.e., hallucinations...
  13. pmc Underestimated effect sizes in GWAS: fundamental limitations of single SNP analysis for dichotomous phenotypes
    Sven Stringer
    Department of Psychiatry, Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, Utrecht, The Netherlands
    PLoS ONE 6:e27964. 2011
    ..Therefore, when a multi-locus model of disease risk is assumed, a multi SNP analysis may be more appropriate...