Research Topics
| Eske M DerksSummaryAffiliation: University Medical Center Utrecht Country: The Netherlands Publications
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Detail Information
Publications
Kraepelin was right: a latent class analysis of symptom dimensions in patients and controlsEske M Derks
Department of Psychiatry, Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, Heidelberglaan 100, 3584 CX Utrecht, The Netherlands
Schizophr Bull 38:495-505. 2012..In conclusion, symptom heterogeneity is more pronounced in bipolar disorder compared with schizophrenia. Reducing phenotypic heterogeneity within psychosis patients and controls may facilitate etiological research...
Antipsychotic drug treatment in first-episode psychosis: should patients be switched to a different antipsychotic drug after 2, 4, or 6 weeks of nonresponse?Eske M Derks
Rudolf Magnus Institute of Neuroscience, Department of Psychiatry, University Medical Centre Utrecht, Utrecht, The Netherlands
J Clin Psychopharmacol 30:176-80. 2010..However, as the increase in prediction accuracy is modest, it is uncertain whether this improvement is clinically relevant...- Genetic schizophrenia risk variants jointly modulate total brain and white matter volumeAfke F Terwisscha van Scheltinga
Department of Psychiatry, Rudolf Magnus Institute of Neuroscience, University Medical Centre Utrecht, Utrecht
Biol Psychiatry 73:525-31. 2013..It is likely that subsets of disease-associated SNPs are associated with distinct heritable disease-associated phenotypes. Therefore, we examined the shared genetic susceptibility modulating schizophrenia and brain volume... - The treatment of hallucinations in schizophrenia spectrum disordersIris E C Sommer
Neuroscience Division, Psychiatry Department, University Medical Centre Utrecht and Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, PO Box 85500, 3508 GA, Utrecht, The Netherlands
Schizophr Bull 38:704-14. 2012..Electroconvulsive therapy (ECT) is considered a last resort for treatment-resistant psychosis. Although several studies showed clinical improvement, a specific reduction in hallucination severity has never been demonstrated... - No evidence that common genetic risk variation is shared between schizophrenia and autismJacob A S Vorstman
Rudolf Magnus Institute of Neuroscience, Department of Psychiatry, University Medical Center Utrecht, Utrecht, The Netherlands
Am J Med Genet B Neuropsychiatr Genet 162:55-60. 2013..These findings provide important novel insights into shared and distinct elements of the genetic architecture of autism and schizophrenia... - Focal and global brain measurements in siblings of patients with schizophreniaHeleen B M Boos
Rudolf Magnus Institute of Neuroscience, Department of Psychiatry, University Medical Center Utrecht, The Netherlands
Schizophr Bull 38:814-25. 2012..This large magnetic resonance imaging study examined brain structures in patients with schizophrenia, their nonpsychotic siblings, and healthy control subjects using global and focal brain measurements... - Segment-wise genome-wide association analysis identifies a candidate region associated with schizophrenia in three independent samplesThomas E Gladwin
Department of Psychiatry, Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, Utrecht, The Netherlands
PLoS ONE 7:e38828. 2012..We conclude that considering relatively wide segments of chromosomes may reveal reliable relationships between the genome and schizophrenia, suggesting novel methodological possibilities as well as raising theoretical questions... - Investigation of the genetic association between quantitative measures of psychosis and schizophrenia: a polygenic risk score analysisEske M Derks
Department of Psychiatry, Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, The Netherlands
PLoS ONE 7:e37852. 2012..This does not necessarily imply that a genetic basis is nonexistent, but does suggest that it is distinct from the polygenic risk score for schizophrenia... - The relationship of DNA methylation with age, gender and genotype in twins and healthy controlsMarco P Boks
Rudolf Magnus Institute of Neuroscience, Department of Psychiatry, University Medical Center Utrecht, Utrecht, The Netherlands
PLoS ONE 4:e6767. 2009..The identification of CpG loci of which DNA methylation levels are under genetic control or are related to age or gender will facilitate further studies into the role of DNA methylation and disease... - The influence of semantic top-down processing in auditory verbal hallucinationsKirstin Daalman
Department of Psychiatry, Neuroscience Division, University Medical Center Utrecht and Rudolf Magnus Institute for Neuroscience, Heidelberglaan 100, 3584 CX Utrecht, The Netherlands
Schizophr Res 139:82-6. 2012..g., expectations), reducing the influence of bottom-up information coming from the sense organs. This bias predisposes to false perceptions, i.e., hallucinations... - The identification of family subtype based on the assessment of subclinical levels of psychosis in relativesEske M Derks
University Medical Center Utrecht, Department of Psychiatry, Rudolf Magnus Institute of Neuroscience, AMC APC, room PA1 179 Meibergdreef, Amsterdam, AZ 51105, The Netherlands
BMC Psychiatry 12:71. 2012..We will introduce a more refined method to distinguish between family subtypes based on psychosis dimension profiles in the relatives of schizophrenia patients... - Underestimated effect sizes in GWAS: fundamental limitations of single SNP analysis for dichotomous phenotypesSven Stringer
Department of Psychiatry, Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, Utrecht, The Netherlands
PLoS ONE 6:e27964. 2011..Therefore, when a multi-locus model of disease risk is assumed, a multi SNP analysis may be more appropriate...