Damiaan Denys

Summary

Affiliation: University Medical Center Utrecht
Country: The Netherlands

Publications

  1. ncbi Prediction of response to paroxetine and venlafaxine by serotonin-related genes in obsessive-compulsive disorder in a randomized, double-blind trial
    Damiaan Denys
    Department of Psychiatry, The Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, Utrecht, The Netherlands
    J Clin Psychiatry 68:747-53. 2007
  2. ncbi Pharmacotherapy of obsessive-compulsive disorder and obsessive-compulsive spectrum disorders
    Damiaan Denys
    Department of Anxiety Disorders, Rudolf Magnus Institute of Neuroscience, Utrecht, The Netherlands
    Psychiatr Clin North Am 29:553-84, xi. 2006
  3. ncbi Association between serotonergic candidate genes and specific phenotypes of obsessive compulsive disorder
    Damiaan Denys
    Rudolf Magnus Institute of Neuroscience, Department of Psychiatry University Medical Center Utrecht, Utrecht, The Netherlands
    J Affect Disord 91:39-44. 2006
  4. doi Catechol-O-methyltranferase gene expression is associated with response to citalopram in obsessive-compulsive disorder
    Nienke C C Vulink
    Department of Psychiatry, AMC, University of Amsterdam, Amsterdam, The Netherlands
    Int J Psychiatry Clin Pract 16:277-83. 2012
  5. ncbi Effects of paroxetine and venlafaxine on immune parameters in patients with obsessive compulsive disorder
    Damiaan Denys
    Department of Psychiatry, UMC, Rudolf Magnus Institute of Neuroscience, B 01 206, P O Box 85500, 3508 GA Utrecht, The Netherlands
    Psychoneuroendocrinology 31:355-60. 2006
  6. ncbi Quetiapine augments the effect of citalopram in non-refractory obsessive-compulsive disorder: a randomized, double-blind, placebo-controlled study of 76 patients
    Nienke C C Vulink
    Rudolf Magnus Institute of Neuroscience, Department of Psychiatry, University Medical Centre Utrecht, Utrecht, The Netherlands
    J Clin Psychiatry 70:1001-8. 2009
  7. ncbi A double-blind, randomized, placebo-controlled trial of quetiapine addition in patients with obsessive-compulsive disorder refractory to serotonin reuptake inhibitors
    Damiaan Denys
    Rudolf Magnus Institute of Neuroscience, Department of Psychiatry, University Medical Center Utrecht, Utrecht, The Netherlands
    J Clin Psychiatry 65:1040-8. 2004
  8. ncbi Female hormones affect symptom severity in obsessive-compulsive disorder
    Nienke C C Vulink
    The Rudolf Magnus Institute of Neuroscience, Department of Psychiatry, University Medical Center Utrecht, Utrecht, The Netherlands
    Int Clin Psychopharmacol 21:171-5. 2006
  9. doi Deep brain stimulation of the nucleus accumbens for treatment-refractory obsessive-compulsive disorder
    Damiaan Denys
    Department of Psychiatry, Academic Medical Center, University of Amsterdam, The Netherlands
    Arch Gen Psychiatry 67:1061-8. 2010
  10. doi Deep brain stimulation for obsessive-compulsive disorders: long-term analysis of quality of life
    Pieter Ooms
    Department of Psychiatry, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    J Neurol Neurosurg Psychiatry 85:153-8. 2014

Collaborators

Detail Information

Publications59

  1. ncbi Prediction of response to paroxetine and venlafaxine by serotonin-related genes in obsessive-compulsive disorder in a randomized, double-blind trial
    Damiaan Denys
    Department of Psychiatry, The Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, Utrecht, The Netherlands
    J Clin Psychiatry 68:747-53. 2007
    ..The purpose of the present study was to determine whether polymorphisms of the serotonin transporter (5-HTT), 5-HT1B, and 5-HT2A receptor genes affect the efficacy of SRI treatment in OCD...
  2. ncbi Pharmacotherapy of obsessive-compulsive disorder and obsessive-compulsive spectrum disorders
    Damiaan Denys
    Department of Anxiety Disorders, Rudolf Magnus Institute of Neuroscience, Utrecht, The Netherlands
    Psychiatr Clin North Am 29:553-84, xi. 2006
    ..In case of non-response, treatment options comprise adding another drug, increasing the dose, switching drugs, or changing the mode of delivery...
  3. ncbi Association between serotonergic candidate genes and specific phenotypes of obsessive compulsive disorder
    Damiaan Denys
    Rudolf Magnus Institute of Neuroscience, Department of Psychiatry University Medical Center Utrecht, Utrecht, The Netherlands
    J Affect Disord 91:39-44. 2006
    ..The purpose of the present study was to investigate the role of the serotonin transporter (5-HTT) and serotonin 5-HT1B and 5-HT2A receptor genes in OCD...
  4. doi Catechol-O-methyltranferase gene expression is associated with response to citalopram in obsessive-compulsive disorder
    Nienke C C Vulink
    Department of Psychiatry, AMC, University of Amsterdam, Amsterdam, The Netherlands
    Int J Psychiatry Clin Pract 16:277-83. 2012
    ..To determine whether polymorphisms of the dopamine D(2) receptor (DRD2) and catechol-O-methyl-transferase (COMT) receptor genes affect the efficacy of quetiapine addition to citalopram in patients with OCD...
  5. ncbi Effects of paroxetine and venlafaxine on immune parameters in patients with obsessive compulsive disorder
    Damiaan Denys
    Department of Psychiatry, UMC, Rudolf Magnus Institute of Neuroscience, B 01 206, P O Box 85500, 3508 GA Utrecht, The Netherlands
    Psychoneuroendocrinology 31:355-60. 2006
    ..This study was carried out to investigate whether treatment with paroxetine and venlafaxine modifies the immune function in OCD and whether this modification is related to treatment outcome...
  6. ncbi Quetiapine augments the effect of citalopram in non-refractory obsessive-compulsive disorder: a randomized, double-blind, placebo-controlled study of 76 patients
    Nienke C C Vulink
    Rudolf Magnus Institute of Neuroscience, Department of Psychiatry, University Medical Centre Utrecht, Utrecht, The Netherlands
    J Clin Psychiatry 70:1001-8. 2009
    ..To assess the efficacy of quetiapine addition to citalopram in treatment-naive or medication-free obsessive-compulsive disorder (OCD) patients...
  7. ncbi A double-blind, randomized, placebo-controlled trial of quetiapine addition in patients with obsessive-compulsive disorder refractory to serotonin reuptake inhibitors
    Damiaan Denys
    Rudolf Magnus Institute of Neuroscience, Department of Psychiatry, University Medical Center Utrecht, Utrecht, The Netherlands
    J Clin Psychiatry 65:1040-8. 2004
    ..This study was conducted to evaluate the efficacy and tolerability of quetiapine in addition to an SRI for treatment-refractory patients with OCD...
  8. ncbi Female hormones affect symptom severity in obsessive-compulsive disorder
    Nienke C C Vulink
    The Rudolf Magnus Institute of Neuroscience, Department of Psychiatry, University Medical Center Utrecht, Utrecht, The Netherlands
    Int Clin Psychopharmacol 21:171-5. 2006
    ..Because reproductive cycle events influence the symptom severity of OCD, the menstrual cycle should be taken into account when assessing the severity of OCD symptoms during pharmacological studies...
  9. doi Deep brain stimulation of the nucleus accumbens for treatment-refractory obsessive-compulsive disorder
    Damiaan Denys
    Department of Psychiatry, Academic Medical Center, University of Amsterdam, The Netherlands
    Arch Gen Psychiatry 67:1061-8. 2010
    ..Even when the best available treatments are applied, approximately 10% of patients remain severely afflicted and run a long-term deteriorating course of OCD...
  10. doi Deep brain stimulation for obsessive-compulsive disorders: long-term analysis of quality of life
    Pieter Ooms
    Department of Psychiatry, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    J Neurol Neurosurg Psychiatry 85:153-8. 2014
    ..To evaluate the long-term effects of deep brain stimulation (DBS) on quality of life (QOL) in therapy-refractory obsessive-compulsive disorder (OCD) patients...
  11. doi Deep brain stimulation restores frontostriatal network activity in obsessive-compulsive disorder
    Martijn Figee
    Department of Psychiatry, Academic Medical Center, Amsterdam, The Netherlands
    Nat Neurosci 16:386-7. 2013
    ..Our findings suggest that DBS is able to reduce maladaptive activity and connectivity of the stimulated region...
  12. doi Deep brain stimulation of the accumbens increases dopamine, serotonin, and noradrenaline in the prefrontal cortex
    Addy van Dijk
    Department of Psychiatry, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    J Neurochem 123:897-903. 2012
    ..These results provide further evidence for the distal effects of DBS and corroborate previous clinical and pre-clinical findings of altered neuronal activity in prefrontal areas...
  13. ncbi Effects of quetiapine on cognitive functioning in obsessive-compulsive disorder
    Femke de Geus
    Department of Psychiatry, Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, Utrecht, The Netherlands
    Int Clin Psychopharmacol 22:77-84. 2007
    ..It is proposed that this failure may be caused by attention difficulties owing to somnolence...
  14. ncbi A double-blind switch study of paroxetine and venlafaxine in obsessive-compulsive disorder
    Damiaan Denys
    Rudolf Magnus Institute of Neuroscience, Department of Psychiatry, University Medical Center Utrecht, Utrecht, The Netherlands
    J Clin Psychiatry 65:37-43. 2004
    ..However, no controlled research has been published yet that prospectively examined the effects of changing SRIs. This article describes the first double-blind switch study of 2 SRIs in patients with OCD...
  15. doi Deep brain stimulation for obsessive-compulsive disorder is associated with cortisol changes
    Pelle P de Koning
    Department of Psychiatry, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Psychoneuroendocrinology 38:1455-9. 2013
    ..The increase in Y-BOCS (39%), and HAM-D (78%) scores correlated strongly with increased UFC levels in the OFF condition. Our findings indicate that symptom changes following DBS for OCD patients are associated with changes in UFC levels...
  16. doi Lipopolysaccharide-induced cytokine production in obsessive-compulsive disorder and generalized social anxiety disorder
    Sjoerd Fluitman
    The Rudolf Magnus Institute of Neuroscience, Department of Psychiatry, University Medical Center Utrecht, Utrecht, The Netherlands
    Psychiatry Res 178:313-6. 2010
    ..This supports the idea of immunological involvement in the pathophysiology of OCD and suggests that GSAD and OCD might be different in immunological respect...
  17. ncbi Quetiapine addition in obsessive-compulsive disorder: is treatment outcome affected by type and dose of serotonin reuptake inhibitors?
    Damiaan Denys
    The Rudolf Magnus Institute of Neuroscience, Department of Psychiatry, University Medical Center Utrecht, Utrecht, The Netherlands
    Biol Psychiatry 61:412-4. 2007
    ..The purpose of this study was to assess the effect of type and dose of serotonin reuptake inhibitors (SRIs) on treatment outcome in quetiapine addition trials for obsessive-compulsive disorder...
  18. ncbi Symptom dimensions in obsessive-compulsive disorder: factor analysis on a clinician-rated scale and a self-report measure
    Damiaan Denys
    Department of Psychiatry, University Medical Centre, Utrecht, The Netherlands
    Psychopathology 37:181-9. 2004
    ..This means that the use of both clinician-administered and self-report measures is recommended, so that the entire spectrum of symptoms is represented...
  19. ncbi A double blind comparison of venlafaxine and paroxetine in obsessive-compulsive disorder
    Damiaan Denys
    Department of Psychiatry, University Medical Center B 01 206, PO Box 85500, 3508 GA Utrecht, The Netherlands
    J Clin Psychopharmacol 23:568-75. 2003
    ..These results show that venlafaxine was equally effective to paroxetine in treating patients with OCD. Venlafaxine may be a useful therapy for obsessive-compulsive patients, but is not superior to SSRIs...
  20. ncbi A score for predicting response to pharmacotherapy in obsessive-compulsive disorder
    Damiaan Denys
    Rudolf Magnus Institute of Neuroscience, Department of Psychiatry, University Medical Center Utrecht, The Netherlands
    Int Clin Psychopharmacol 18:315-22. 2003
    ..63-0.8), demonstrating a reasonable discriminatory power. This study is the first to present a model that can estimate by the use of prediction rules the probability of treatment response to antidepressants in patients with OCD...
  21. doi Surgery for psychiatric disorders
    Judy Luigjes
    Department of Psychiatry, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    World Neurosurg 80:S31.e17-28. 2013
    ..In addition, new indications for DBS and new target options should be explored in preclinical research. ..
  22. doi Review of atypical antipsychotics in anxiety
    Nienke C C Vulink
    Department of Psychiatry, Academic Medical Center, University of Amsterdam, The Netherlands
    Eur Neuropsychopharmacol 21:429-49. 2011
    ..In addition, higher dropout rates and side effects from treatment with atypical antipsychotics may limit the use of atypical antipsychotics in patients with anxiety disorders...
  23. doi Current status of deep brain stimulation for obsessive-compulsive disorder: a clinical review of different targets
    Pelle P de Koning
    Department of Psychiatry, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Curr Psychiatry Rep 13:274-82. 2011
    ..We conclude that DBS may be a promising and safe therapy for treatment-resistant OCD...
  24. doi Dysfunctional reward circuitry in obsessive-compulsive disorder
    Martijn Figee
    Department of Psychiatry, Academic Medical Center, Amsterdam, The Netherlands
    Biol Psychiatry 69:867-74. 2011
    ..This is the first functional imaging study to investigate explicitly reward circuitry in OCD...
  25. ncbi Sexual pleasure in women with obsessive-compulsive disorder?
    Nienke C C Vulink
    The Rudolf Magnus Institute of Neuroscience, Department of Psychiatry, University Medical Center Utrecht UMCU, B 01 206, P O Box 85500, 3508 GA Utrecht, The Netherlands
    J Affect Disord 91:19-25. 2006
    ..This study compared subjective appreciation of sexuality and sexual functioning between OCD patients and healthy subjects and controlled for the influence of medication or OCD subtypes on sexual functioning and satisfaction...
  26. ncbi Association between the dopamine D2 receptor TaqI A2 allele and low activity COMT allele with obsessive-compulsive disorder in males
    Damiaan Denys
    Rudolf Magnus Institute of Neuroscience, Department of Psychiatry University Medical Center Utrecht, Utrecht, The Netherlands
    Eur Neuropsychopharmacol 16:446-50. 2006
    ..Mounting evidence suggests the involvement of the dopamine system in the pathophysiology of obsessive-compulsive disorder...
  27. ncbi The role of dopamine in obsessive-compulsive disorder: preclinical and clinical evidence
    Damiaan Denys
    Rudolf Magnus Institute of Neuroscience, Department of Psychiatry, University Medical Center Utrecht, Utrecht, The Netherlands
    J Clin Psychiatry 65:11-7. 2004
    ..In this review, the preclinical and clinical evidence on the role of dopamine in OCD is summarized...
  28. pmc Compulsive carnival song whistling following cardiac arrest: a case study
    A Rosaura Polak
    Department of Anxiety Disorders, Academic Medical Center AMC, University of Amsterdam UvA, Meibergdreef 5, Amsterdam, 1105 AZ, The Netherlands
    BMC Psychiatry 12:75. 2012
    ..In this case report, we describe a patient who developed compulsivity following cardiac arrest. We review diagnostic options, underlying mechanisms and possible treatments...
  29. pmc Comparison of the effectiveness of trauma-focused cognitive behavioral therapy and paroxetine treatment in PTSD patients: design of a randomized controlled trial
    A Rosaura Polak
    Academic Medical Center, Department of Anxiety Disorders, University of Amsterdam, Meibergdreef 5, Amsterdam 1105 AZ, The Netherlands
    BMC Psychiatry 12:166. 2012
    ..International guidelines recommend trauma-focused psychological interventions for all PTSD patients as first-line treatment (NICE). However, no clear-cut evidence is available to support this recommendation...
  30. doi Co-occurrence of obsessive-compulsive disorder and substance use disorder in the general population
    Rianne M Blom
    Department of Psychiatry, Academical Medical Centre, University of Amsterdam, Amsterdam, The Netherlands
    Addiction 106:2178-85. 2011
    ..The aim of this study is to compare the co-occurrence of OCD with SUD to the co-occurrence of SUD with other psychiatric disorders in a representative community sample...
  31. ncbi Use of factor analysis to detect potential phenotypes in obsessive-compulsive disorder
    Damiaan Denys
    Department of Psychiatry, University Medical Center, HP B 01 206, PO Box 85500, GA Utrecht 3508, The Netherlands
    Psychiatry Res 128:273-80. 2004
    ..We observed significant differences in sex distribution, age of onset, Y-BOCS scores and familial prevalence of OCD in relation to the symptom dimensions. These findings provide further evidence for distinct clinical phenotypes in OCD...
  32. ncbi Emerging skin-picking behaviour after serotonin reuptake inhibitor-treatment in patients with obsessive-compulsive disorder: possible mechanisms and implications for clinical care
    Damiaan Denys
    Department of Psychiatry, University Medical Centre, Utrecht, The Netherlands
    J Psychopharmacol 17:127-9. 2003
    ..Two case reports are presented demonstrating that SSRI-treatment may induce or aggravate pathological skin-picking behaviour. Possible mechanisms of SSRI-induced pathological skin-picking and implications for clinical care are discussed...
  33. ncbi New pharmacotherapeutic approaches to obsessive-compulsive disorder
    Martijn Figee
    Department of Psychiatry, Academic Medical Centre, University of Amsterdam, The Netherlands
    CNS Spectr 14:13-23. 2009
    ..Lastly, successful treatment with an SSRI results in both serotonergic and dopaminergic changes, but more research is necessary in order to define the biological characteristics of responders and nonresponders...
  34. ncbi Bupropion for patients with obsessive-compulsive disorder: an open-label, fixed-dose study
    Nienke C C Vulink
    Department of Psychiatry, University Medical Center Utrecht, The Rudolf Magnus Institute of Neuroscience, Utrecht, The Netherlands
    J Clin Psychiatry 66:228-30. 2005
    ..In the present study, we examined the efficacy of bupropion for patients with obsessive-compulsive disorder (OCD)...
  35. ncbi Spatial working memory in obsessive-compulsive disorder improves with clinical response: A functional MRI study
    Nic J A van der Wee
    Rudolf Magnus Institute of Neuroscience, Department of Psychiatry, University Medical Center Utrecht, Heidelberglaan 100, 3584 X Utrecht, The Netherlands
    Eur Neuropsychopharmacol 17:16-23. 2007
    ..Our preliminary findings suggests that spatial working memory deficits in OCD and their functional anatomical correlates, as assessed with a spatial n-back task, are, at least to some extent, state dependent...
  36. ncbi Cognitive functioning in psychiatric disorders following deep brain stimulation
    Isidoor O Bergfeld
    Department of Psychiatry, Academic Medical Center, University of Amsterdam, P O Box 22660, 1100 DD Amsterdam, The Netherlands
    Brain Stimul 6:532-7. 2013
    ..Although cognitive deterioration has repeatedly been shown in patients with Parkinson's disease following DBS, the impact of DBS on cognitive functioning in psychiatric patients has not yet been reviewed...
  37. doi Neurosurgical targets for compulsivity: what can we learn from acquired brain lesions?
    Martijn Figee
    Department of Psychiatry, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Neurosci Biobehav Rev 37:328-39. 2013
    ..These case reports provide strong evidence supporting the rationale for DBS in the ventral striatum and internal capsule for treatment of compulsivity and reveal the putamen and fronto-parietal cortex as promising new targets...
  38. doi Deep brain stimulation increases impulsivity in two patients with obsessive-compulsive disorder
    Judy Luigjes
    Department of Psychiatry, Academic Medical Center, University of Amsterdam, The Netherlands
    Int Clin Psychopharmacol 26:338-40. 2011
    ..Location and amplitude of stimulation might be critical in inducing these behaviours. These two cases underline the importance of a careful clinical assessment of impulsive behaviours during DBS for OCD...
  39. ncbi Predictors of pharmacotherapy response in anxiety disorders
    Damiaan Denys
    Rudolf Magnus Institute of Neuroscience, Department of Psychiatry, University Medical Center, 3508 GA Utrecht, The Netherlands
    Curr Psychiatry Rep 7:252-7. 2005
    ..Prediction of treatment response may be founded on demographic and clinical variables, neurochemical and electrophysiologic parameters, imaging studies, and genetic markers...
  40. doi Compulsivity in mouse strains homologous with chromosomes 7p and 15q linked to obsessive-compulsive disorder
    Martien J H Kas
    Department of Neuroscience and Pharmacology, Rudolf Magnus Institute of Neuroscience, University Medical Centre Utrecht, Utrecht, The Netherlands
    Am J Med Genet B Neuropsychiatr Genet 153:252-9. 2010
    ..Genetic fine mapping of compulsivity in mice provides new opportunities to reveal mechanisms underlying this significant psychiatric trait...
  41. ncbi A case of venlafaxine-induced inhibition of T-lymphocyte proliferation
    Damiaan Denys
    Department of Psychiatry, University Medical Center, Utrecht, The Netherlands
    Psychopharmacology (Berl) 164:432. 2002
  42. ncbi Low level of dopaminergic D2 receptor binding in obsessive-compulsive disorder
    Damiaan Denys
    Rudolf Magnus Institute of Neuroscience, Department of Psychiatry, University Medical Center Utrecht, Utrecht, The Netherlands
    Biol Psychiatry 55:1041-5. 2004
    ..Despite growing evidence for involvement of the dopaminergic system in obsessive-compulsive disorder (OCD), the functional anatomy of the dopaminergic system in the basal ganglia has been investigated sparsely...
  43. doi Relation between structural and functional connectivity in major depressive disorder
    Bart de Kwaasteniet
    Department of Psychiatry, Brain Imaging Center, Amsterdam, The Netherlands
    Biol Psychiatry 74:40-7. 2013
    ..Here, we used a multimodal neuroimaging approach to investigate the relation between structural connectivity and functional connectivity within the frontolimbic network...
  44. pmc Misophonia: diagnostic criteria for a new psychiatric disorder
    Arjan Schröder
    Department of Psychiatry, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    PLoS ONE 8:e54706. 2013
    ..This condition is relatively unknown and has hitherto never been described, although the phenomenon has anecdotally been named misophonia...
  45. doi Unilateral deep brain stimulation in the nucleus accumbens core does not affect local monoamine release
    Addy van Dijk
    Department of Psychiatry, Academic Medical Center, University of Amsterdam, Postbus 22660, 1100 DD Amsterdam, The Netherlands
    J Neurosci Methods 202:113-8. 2011
    ..For future directions it is interesting to note that several microdialysis and electrophysiology studies have shown effects of DBS in areas distant from the stimulation target...
  46. ncbi Decreased TNF-alpha and NK activity in obsessive-compulsive disorder
    Damiaan Denys
    Rudolf Magnus Institute of Neuroscience, Department of Psychiatry, University Medical Center Utrecht, Utrecht, The Netherlands
    Psychoneuroendocrinology 29:945-52. 2004
    ..This study was carried out to investigate whether obsessive-compulsive disorder is associated with altered activity of the immune system, and whether these changes are related to particular clinical characteristics...
  47. ncbi Synergistic dopamine increase in the rat prefrontal cortex with the combination of quetiapine and fluvoxamine
    Damiaan Denys
    Department of Psychiatry, The Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, P O Box 85500, 3508 GA Utrecht, The Netherlands
    Psychopharmacology (Berl) 176:195-203. 2004
    ....
  48. doi Smoking cessation and weight loss after chronic deep brain stimulation of the nucleus accumbens: therapeutic and research implications: case report
    Mariska Mantione
    Department of Psychiatry, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Neurosurgery 66:E218; discussion E218. 2010
    ..In this case report, we describe a patient who quit smoking and lost weight without any effort, and we review the underlying mechanisms of action...
  49. ncbi Quetiapine addition to serotonin reuptake inhibitor treatment in patients with treatment-refractory obsessive-compulsive disorder: an open-label study
    Damiaan Denys
    Department of Psychiatry, University Medical Center, Utrecht, The Netherlands
    J Clin Psychiatry 63:700-3. 2002
    ..The objective of this study was to examine whether addition of the atypical antipsychotic quetiapine to SRIs is useful for patients with OCD who do not respond to SRI monotherapy...
  50. pmc Update on repetitive transcranial magnetic stimulation in obsessive-compulsive disorder: different targets
    Rianne M Blom
    Department of Psychiatry, Academic Medical Center, University of Amsterdam, PA 3 127, P O Box 75867, 1070 AW, Amsterdam, The Netherlands
    Curr Psychiatry Rep 13:289-94. 2011
    ..In general, rTMS appears to be effective in open-label studies; however, this has not yet been replicated in randomized, sham-controlled trials...
  51. doi Is deep brain stimulation a treatment option for anorexia nervosa?
    Marloes S Oudijn
    Department of Psychiatry, Academic Medical Centre, University of Amsterdam, Meibergdreef 5, 1105, AZ Amsterdam, The Netherlands
    BMC Psychiatry 13:277. 2013
    ..Possible targets for DBS in AN are the ACC, the ventral anterior limb of the capsula interna (vALIC) and the VS. We suggest conducting larger efficacy studies that also explore the functional effects of DBS in AN. ..
  52. doi Incidence and prevalence of "diagnosed OCD" in a primary care, treatment seeking, population
    Joris Veldhuis
    Department of Psychiatry, Academic Medical Centre, University of Amsterdam, Amsterdam, The Netherlands
    Int J Psychiatry Clin Pract 16:85-92. 2012
    ..To obtain valid and accurate estimates of the incidence and prevalence of OCD in a treatment-seeking primary care population and to compare these estimates with estimates from epidemiological community studies...
  53. doi Incidence rates and risk factors of bipolar disorder in the general population: a population-based cohort study
    Jojanneke S Kroon
    Department of Psychiatry, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Bipolar Disord 15:306-13. 2013
    ..To estimate the incidence rates (IRs) of bipolar I and bipolar II disorders in the general population according to sociodemographic population characteristics...
  54. pmc Testing the effects of Δ9-THC and D-cycloserine on extinction of conditioned fear in humans
    Floris Klumpers
    Experimental Psychology and Helmholtz Institute, Utrecht University, Utrecht, The Netherlands
    J Psychopharmacol 26:471-8. 2012
    ..The apparent discrepancy between these findings and the results from (pre-)clinical trials is discussed in terms of room for improvement in these systems in healthy volunteers, and the lack of specificity of THC as a CB(1) agonist...
  55. pmc Body integrity identity disorder
    Rianne M Blom
    Department of Psychiatry, Academic Medical Centre, University of Amsterdam, Amsterdam, The Netherlands
    PLoS ONE 7:e34702. 2012
    ..Aim of the study is to broaden the knowledge of BIID amongst medical professionals, by describing all who deal with BIID...
  56. doi Deep brain stimulation in obsessive-compulsive disorder
    Damiaan Denys
    Department of Psychiatry, AMC, Netherlands Institute for Neuroscience, Amsterdam, The Netherlands
    Prog Brain Res 175:419-27. 2009
    ..The speed of the effect of deep brain stimulation causes fundamental assumptions on the pathophysiology of obsessive-compulsive disorder...
  57. ncbi Adjunctive quetiapine for serotonin reuptake inhibitor-resistant obsessive-compulsive disorder: a meta-analysis of randomized controlled treatment trials
    Naomi A Fineberg
    Hertfordshire Partnership NHS Trust, UK
    Int Clin Psychopharmacol 21:337-43. 2006
    ..008), the clinical significance of which was limited by between-study heterogeneity. The mechanism underlying the effect may involve serotonin and/or dopamine neurotransmission...
  58. ncbi Axis I and II comorbidity in a large sample of patients with obsessive-compulsive disorder
    Damiaan Denys
    University Medical Center B 01 206, P O Box 85500, 3508 GA Utrecht, The Netherlands
    J Affect Disord 80:155-62. 2004
    ....
  59. ncbi Predicting pharmacotherapy outcome from a retrospective chart study?
    Carla de Bruijn
    J Clin Psychiatry 68:167; author reply 167-8. 2007