D Denys

Summary

Affiliation: University Medical Center Utrecht
Country: The Netherlands

Publications

  1. ncbi Association between serotonergic candidate genes and specific phenotypes of obsessive compulsive disorder
    Damiaan Denys
    Rudolf Magnus Institute of Neuroscience, Department of Psychiatry University Medical Center Utrecht, Utrecht, The Netherlands
    J Affect Disord 91:39-44. 2006
  2. ncbi Association between the dopamine D2 receptor TaqI A2 allele and low activity COMT allele with obsessive-compulsive disorder in males
    Damiaan Denys
    Rudolf Magnus Institute of Neuroscience, Department of Psychiatry University Medical Center Utrecht, Utrecht, The Netherlands
    Eur Neuropsychopharmacol 16:446-50. 2006
  3. ncbi Effects of paroxetine and venlafaxine on immune parameters in patients with obsessive compulsive disorder
    Damiaan Denys
    Department of Psychiatry, UMC, Rudolf Magnus Institute of Neuroscience, B 01 206, P O Box 85500, 3508 GA Utrecht, The Netherlands
    Psychoneuroendocrinology 31:355-60. 2006
  4. ncbi Predictors of pharmacotherapy response in anxiety disorders
    Damiaan Denys
    Rudolf Magnus Institute of Neuroscience, Department of Psychiatry, University Medical Center, 3508 GA Utrecht, The Netherlands
    Curr Psychiatry Rep 7:252-7. 2005
  5. ncbi The role of dopamine in obsessive-compulsive disorder: preclinical and clinical evidence
    Damiaan Denys
    Rudolf Magnus Institute of Neuroscience, Department of Psychiatry, University Medical Center Utrecht, Utrecht, The Netherlands
    J Clin Psychiatry 65:11-7. 2004
  6. ncbi Use of factor analysis to detect potential phenotypes in obsessive-compulsive disorder
    Damiaan Denys
    Department of Psychiatry, University Medical Center, HP B 01 206, PO Box 85500, GA Utrecht 3508, The Netherlands
    Psychiatry Res 128:273-80. 2004
  7. ncbi A double-blind, randomized, placebo-controlled trial of quetiapine addition in patients with obsessive-compulsive disorder refractory to serotonin reuptake inhibitors
    Damiaan Denys
    Rudolf Magnus Institute of Neuroscience, Department of Psychiatry, University Medical Center Utrecht, Utrecht, The Netherlands
    J Clin Psychiatry 65:1040-8. 2004
  8. ncbi Decreased TNF-alpha and NK activity in obsessive-compulsive disorder
    Damiaan Denys
    Rudolf Magnus Institute of Neuroscience, Department of Psychiatry, University Medical Center Utrecht, Utrecht, The Netherlands
    Psychoneuroendocrinology 29:945-52. 2004
  9. ncbi Synergistic dopamine increase in the rat prefrontal cortex with the combination of quetiapine and fluvoxamine
    Damiaan Denys
    Department of Psychiatry, The Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, P O Box 85500, 3508 GA Utrecht, The Netherlands
    Psychopharmacology (Berl) 176:195-203. 2004
  10. ncbi Quetiapine addition to serotonin reuptake inhibitor treatment in patients with treatment-refractory obsessive-compulsive disorder: an open-label study
    Damiaan Denys
    Department of Psychiatry, University Medical Center, Utrecht, The Netherlands
    J Clin Psychiatry 63:700-3. 2002

Collaborators

Detail Information

Publications42

  1. ncbi Association between serotonergic candidate genes and specific phenotypes of obsessive compulsive disorder
    Damiaan Denys
    Rudolf Magnus Institute of Neuroscience, Department of Psychiatry University Medical Center Utrecht, Utrecht, The Netherlands
    J Affect Disord 91:39-44. 2006
    ..The purpose of the present study was to investigate the role of the serotonin transporter (5-HTT) and serotonin 5-HT1B and 5-HT2A receptor genes in OCD...
  2. ncbi Association between the dopamine D2 receptor TaqI A2 allele and low activity COMT allele with obsessive-compulsive disorder in males
    Damiaan Denys
    Rudolf Magnus Institute of Neuroscience, Department of Psychiatry University Medical Center Utrecht, Utrecht, The Netherlands
    Eur Neuropsychopharmacol 16:446-50. 2006
    ..Mounting evidence suggests the involvement of the dopamine system in the pathophysiology of obsessive-compulsive disorder...
  3. ncbi Effects of paroxetine and venlafaxine on immune parameters in patients with obsessive compulsive disorder
    Damiaan Denys
    Department of Psychiatry, UMC, Rudolf Magnus Institute of Neuroscience, B 01 206, P O Box 85500, 3508 GA Utrecht, The Netherlands
    Psychoneuroendocrinology 31:355-60. 2006
    ..This study was carried out to investigate whether treatment with paroxetine and venlafaxine modifies the immune function in OCD and whether this modification is related to treatment outcome...
  4. ncbi Predictors of pharmacotherapy response in anxiety disorders
    Damiaan Denys
    Rudolf Magnus Institute of Neuroscience, Department of Psychiatry, University Medical Center, 3508 GA Utrecht, The Netherlands
    Curr Psychiatry Rep 7:252-7. 2005
    ..Prediction of treatment response may be founded on demographic and clinical variables, neurochemical and electrophysiologic parameters, imaging studies, and genetic markers...
  5. ncbi The role of dopamine in obsessive-compulsive disorder: preclinical and clinical evidence
    Damiaan Denys
    Rudolf Magnus Institute of Neuroscience, Department of Psychiatry, University Medical Center Utrecht, Utrecht, The Netherlands
    J Clin Psychiatry 65:11-7. 2004
    ..In this review, the preclinical and clinical evidence on the role of dopamine in OCD is summarized...
  6. ncbi Use of factor analysis to detect potential phenotypes in obsessive-compulsive disorder
    Damiaan Denys
    Department of Psychiatry, University Medical Center, HP B 01 206, PO Box 85500, GA Utrecht 3508, The Netherlands
    Psychiatry Res 128:273-80. 2004
    ..We observed significant differences in sex distribution, age of onset, Y-BOCS scores and familial prevalence of OCD in relation to the symptom dimensions. These findings provide further evidence for distinct clinical phenotypes in OCD...
  7. ncbi A double-blind, randomized, placebo-controlled trial of quetiapine addition in patients with obsessive-compulsive disorder refractory to serotonin reuptake inhibitors
    Damiaan Denys
    Rudolf Magnus Institute of Neuroscience, Department of Psychiatry, University Medical Center Utrecht, Utrecht, The Netherlands
    J Clin Psychiatry 65:1040-8. 2004
    ..This study was conducted to evaluate the efficacy and tolerability of quetiapine in addition to an SRI for treatment-refractory patients with OCD...
  8. ncbi Decreased TNF-alpha and NK activity in obsessive-compulsive disorder
    Damiaan Denys
    Rudolf Magnus Institute of Neuroscience, Department of Psychiatry, University Medical Center Utrecht, Utrecht, The Netherlands
    Psychoneuroendocrinology 29:945-52. 2004
    ..This study was carried out to investigate whether obsessive-compulsive disorder is associated with altered activity of the immune system, and whether these changes are related to particular clinical characteristics...
  9. ncbi Synergistic dopamine increase in the rat prefrontal cortex with the combination of quetiapine and fluvoxamine
    Damiaan Denys
    Department of Psychiatry, The Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, P O Box 85500, 3508 GA Utrecht, The Netherlands
    Psychopharmacology (Berl) 176:195-203. 2004
    ....
  10. ncbi Quetiapine addition to serotonin reuptake inhibitor treatment in patients with treatment-refractory obsessive-compulsive disorder: an open-label study
    Damiaan Denys
    Department of Psychiatry, University Medical Center, Utrecht, The Netherlands
    J Clin Psychiatry 63:700-3. 2002
    ..The objective of this study was to examine whether addition of the atypical antipsychotic quetiapine to SRIs is useful for patients with OCD who do not respond to SRI monotherapy...
  11. ncbi Emerging skin-picking behaviour after serotonin reuptake inhibitor-treatment in patients with obsessive-compulsive disorder: possible mechanisms and implications for clinical care
    Damiaan Denys
    Department of Psychiatry, University Medical Centre, Utrecht, The Netherlands
    J Psychopharmacol 17:127-9. 2003
    ..Two case reports are presented demonstrating that SSRI-treatment may induce or aggravate pathological skin-picking behaviour. Possible mechanisms of SSRI-induced pathological skin-picking and implications for clinical care are discussed...
  12. ncbi A score for predicting response to pharmacotherapy in obsessive-compulsive disorder
    Damiaan Denys
    Rudolf Magnus Institute of Neuroscience, Department of Psychiatry, University Medical Center Utrecht, The Netherlands
    Int Clin Psychopharmacol 18:315-22. 2003
    ..63-0.8), demonstrating a reasonable discriminatory power. This study is the first to present a model that can estimate by the use of prediction rules the probability of treatment response to antidepressants in patients with OCD...
  13. ncbi A double blind comparison of venlafaxine and paroxetine in obsessive-compulsive disorder
    Damiaan Denys
    Department of Psychiatry, University Medical Center B 01 206, PO Box 85500, 3508 GA Utrecht, The Netherlands
    J Clin Psychopharmacol 23:568-75. 2003
    ..These results show that venlafaxine was equally effective to paroxetine in treating patients with OCD. Venlafaxine may be a useful therapy for obsessive-compulsive patients, but is not superior to SSRIs...
  14. ncbi A case of venlafaxine-induced inhibition of T-lymphocyte proliferation
    Damiaan Denys
    Department of Psychiatry, University Medical Center, Utrecht, The Netherlands
    Psychopharmacology (Berl) 164:432. 2002
  15. ncbi The adequacy of pharmacotherapy in outpatients with obsessive-compulsive disorder
    D Denys
    Department of Psychiatry, University Medical Center, Utrecht, The Netherlands
    Int Clin Psychopharmacol 17:109-14. 2002
    ..A large proportion of patients with OCD fail to receive adequate treatment. Many patients were prescribed SRIs at doses below those recommended for the guidelines...
  16. ncbi [The inheritance of obsessive-compulsive disorders]
    D A Denys
    Universitair Medisch Centrum Utrecht, Rudolf Magnus Instituut voor Neurowetenschappen, afd Psychiatrie, Postbus 85 500, 3508 GA Utrecht
    Ned Tijdschr Geneeskd 147:2166-9. 2003
    ..Segregation analyses suggest Mendelian inheritance of a dominant allele. In addition to one gene with a major effect, genes with smaller effects also play a role...
  17. ncbi A double-blind switch study of paroxetine and venlafaxine in obsessive-compulsive disorder
    Damiaan Denys
    Rudolf Magnus Institute of Neuroscience, Department of Psychiatry, University Medical Center Utrecht, Utrecht, The Netherlands
    J Clin Psychiatry 65:37-43. 2004
    ..However, no controlled research has been published yet that prospectively examined the effects of changing SRIs. This article describes the first double-blind switch study of 2 SRIs in patients with OCD...
  18. ncbi [Inadequate pharmacotherapy in patients with obsessive-compulsive disorder]
    D Denys
    Universitair Medisch Centrum, afd Psychiatrie, Heidelberglaan 100, 3584 CX, Utrecht
    Ned Tijdschr Geneeskd 145:914-8. 2001
    ..To determine the adequacy of drug treatment for patients with obsessive compulsive disorder (OCD)...
  19. doi Quetiapine augments the effect of citalopram in non-refractory obsessive-compulsive disorder: a randomized, double-blind, placebo-controlled study of 76 patients
    Nienke C C Vulink
    Rudolf Magnus Institute of Neuroscience, Department of Psychiatry, University Medical Centre Utrecht, Utrecht, The Netherlands
    J Clin Psychiatry 70:1001-8. 2009
    ..To assess the efficacy of quetiapine addition to citalopram in treatment-naive or medication-free obsessive-compulsive disorder (OCD) patients...
  20. ncbi Prediction of response to paroxetine and venlafaxine by serotonin-related genes in obsessive-compulsive disorder in a randomized, double-blind trial
    Damiaan Denys
    Department of Psychiatry, The Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, Utrecht, The Netherlands
    J Clin Psychiatry 68:747-53. 2007
    ..The purpose of the present study was to determine whether polymorphisms of the serotonin transporter (5-HTT), 5-HT1B, and 5-HT2A receptor genes affect the efficacy of SRI treatment in OCD...
  21. ncbi Quetiapine addition in obsessive-compulsive disorder: is treatment outcome affected by type and dose of serotonin reuptake inhibitors?
    Damiaan Denys
    The Rudolf Magnus Institute of Neuroscience, Department of Psychiatry, University Medical Center Utrecht, Utrecht, The Netherlands
    Biol Psychiatry 61:412-4. 2007
    ..The purpose of this study was to assess the effect of type and dose of serotonin reuptake inhibitors (SRIs) on treatment outcome in quetiapine addition trials for obsessive-compulsive disorder...
  22. ncbi Effects of quetiapine on cognitive functioning in obsessive-compulsive disorder
    Femke de Geus
    Department of Psychiatry, Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, Utrecht, The Netherlands
    Int Clin Psychopharmacol 22:77-84. 2007
    ..It is proposed that this failure may be caused by attention difficulties owing to somnolence...
  23. ncbi Axis I and II comorbidity in a large sample of patients with obsessive-compulsive disorder
    Damiaan Denys
    University Medical Center B 01 206, P O Box 85500, 3508 GA Utrecht, The Netherlands
    J Affect Disord 80:155-62. 2004
    ....
  24. ncbi [Body dysmorphic disorder in 3-8% of patients in outpatient dermatology and plastic surgery clinics]
    N C C Vulink
    Universitair Medisch Centrum Utrecht, B 01 206, Postbus 85 500, 3508 GA Utrecht
    Ned Tijdschr Geneeskd 150:97-100. 2006
    ..To determine the 6-month prevalence of body dysmorphic disorder (BDD) in outpatient clinics of dermatology and plastic surgery in a university medical centre...
  25. ncbi Bupropion for patients with obsessive-compulsive disorder: an open-label, fixed-dose study
    Nienke C C Vulink
    Department of Psychiatry, University Medical Center Utrecht, The Rudolf Magnus Institute of Neuroscience, Utrecht, The Netherlands
    J Clin Psychiatry 66:228-30. 2005
    ..In the present study, we examined the efficacy of bupropion for patients with obsessive-compulsive disorder (OCD)...
  26. ncbi Sexual pleasure in women with obsessive-compulsive disorder?
    Nienke C C Vulink
    The Rudolf Magnus Institute of Neuroscience, Department of Psychiatry, University Medical Center Utrecht UMCU, B 01 206, P O Box 85500, 3508 GA Utrecht, The Netherlands
    J Affect Disord 91:19-25. 2006
    ..This study compared subjective appreciation of sexuality and sexual functioning between OCD patients and healthy subjects and controlled for the influence of medication or OCD subtypes on sexual functioning and satisfaction...
  27. ncbi Female hormones affect symptom severity in obsessive-compulsive disorder
    Nienke C C Vulink
    The Rudolf Magnus Institute of Neuroscience, Department of Psychiatry, University Medical Center Utrecht, Utrecht, The Netherlands
    Int Clin Psychopharmacol 21:171-5. 2006
    ..Because reproductive cycle events influence the symptom severity of OCD, the menstrual cycle should be taken into account when assessing the severity of OCD symptoms during pharmacological studies...
  28. ncbi Pharmacotherapy of obsessive-compulsive disorder and obsessive-compulsive spectrum disorders
    Damiaan Denys
    Department of Anxiety Disorders, Rudolf Magnus Institute of Neuroscience, Utrecht, The Netherlands
    Psychiatr Clin North Am 29:553-84, xi. 2006
    ..In case of non-response, treatment options comprise adding another drug, increasing the dose, switching drugs, or changing the mode of delivery...
  29. ncbi New pharmacotherapeutic approaches to obsessive-compulsive disorder
    Martijn Figee
    Department of Psychiatry, Academic Medical Centre, University of Amsterdam, The Netherlands
    CNS Spectr 14:13-23. 2009
    ..Lastly, successful treatment with an SSRI results in both serotonergic and dopaminergic changes, but more research is necessary in order to define the biological characteristics of responders and nonresponders...
  30. ncbi Symptom dimensions in obsessive-compulsive disorder: factor analysis on a clinician-rated scale and a self-report measure
    Damiaan Denys
    Department of Psychiatry, University Medical Centre, Utrecht, The Netherlands
    Psychopathology 37:181-9. 2004
    ..This means that the use of both clinician-administered and self-report measures is recommended, so that the entire spectrum of symptoms is represented...
  31. doi Body dysmorphic disorder screening in maxillofacial outpatients presenting for orthognathic surgery
    N C C Vulink
    The Rudolf Magnus Institute of Neuroscience, Department of Psychiatry, The Netherlands
    Int J Oral Maxillofac Surg 37:985-91. 2008
    ..The high prevalence of problems related to psychosocial functioning and the occurrence of BDD in maxillofacial patients means that maxillofacial surgeons should take psychological concerns about physical defects into account...
  32. doi Lipopolysaccharide-induced cytokine production in obsessive-compulsive disorder and generalized social anxiety disorder
    Sjoerd Fluitman
    The Rudolf Magnus Institute of Neuroscience, Department of Psychiatry, University Medical Center Utrecht, Utrecht, The Netherlands
    Psychiatry Res 178:313-6. 2010
    ..This supports the idea of immunological involvement in the pathophysiology of OCD and suggests that GSAD and OCD might be different in immunological respect...
  33. ncbi Spatial working memory in obsessive-compulsive disorder improves with clinical response: A functional MRI study
    Nic J A van der Wee
    Rudolf Magnus Institute of Neuroscience, Department of Psychiatry, University Medical Center Utrecht, Heidelberglaan 100, 3584 X Utrecht, The Netherlands
    Eur Neuropsychopharmacol 17:16-23. 2007
    ..Our preliminary findings suggests that spatial working memory deficits in OCD and their functional anatomical correlates, as assessed with a spatial n-back task, are, at least to some extent, state dependent...
  34. doi Deep brain stimulation of the nucleus accumbens for treatment-refractory obsessive-compulsive disorder
    Damiaan Denys
    Department of Psychiatry, Academic Medical Center, University of Amsterdam, The Netherlands
    Arch Gen Psychiatry 67:1061-8. 2010
    ..Even when the best available treatments are applied, approximately 10% of patients remain severely afflicted and run a long-term deteriorating course of OCD...
  35. ncbi Low level of dopaminergic D2 receptor binding in obsessive-compulsive disorder
    Damiaan Denys
    Rudolf Magnus Institute of Neuroscience, Department of Psychiatry, University Medical Center Utrecht, Utrecht, The Netherlands
    Biol Psychiatry 55:1041-5. 2004
    ..Despite growing evidence for involvement of the dopaminergic system in obsessive-compulsive disorder (OCD), the functional anatomy of the dopaminergic system in the basal ganglia has been investigated sparsely...
  36. ncbi Perception of facial expressions in obsessive-compulsive disorder: a dimensional approach
    B Montagne
    Department of Psychiatry, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Eur Psychiatry 23:26-8. 2008
    ..Results showed that the High Risk Assessment and Checking subtype was more sensitive in perceiving the emotions fear and happiness. This suggests that altered affective processing may underlie the clinical manifestation of OCD...
  37. doi Compulsivity in mouse strains homologous with chromosomes 7p and 15q linked to obsessive-compulsive disorder
    Martien J H Kas
    Department of Neuroscience and Pharmacology, Rudolf Magnus Institute of Neuroscience, University Medical Centre Utrecht, Utrecht, The Netherlands
    Am J Med Genet B Neuropsychiatr Genet 153:252-9. 2010
    ..Genetic fine mapping of compulsivity in mice provides new opportunities to reveal mechanisms underlying this significant psychiatric trait...
  38. doi Deep brain stimulation in obsessive-compulsive disorder
    Damiaan Denys
    Department of Psychiatry, AMC, Netherlands Institute for Neuroscience, Amsterdam, The Netherlands
    Prog Brain Res 175:419-27. 2009
    ..The speed of the effect of deep brain stimulation causes fundamental assumptions on the pathophysiology of obsessive-compulsive disorder...
  39. doi Smoking cessation and weight loss after chronic deep brain stimulation of the nucleus accumbens: therapeutic and research implications: case report
    Mariska Mantione
    Department of Psychiatry, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Neurosurgery 66:E218; discussion E218. 2010
    ..In this case report, we describe a patient who quit smoking and lost weight without any effort, and we review the underlying mechanisms of action...
  40. ncbi Adjunctive quetiapine for serotonin reuptake inhibitor-resistant obsessive-compulsive disorder: a meta-analysis of randomized controlled treatment trials
    Naomi A Fineberg
    Hertfordshire Partnership NHS Trust, UK
    Int Clin Psychopharmacol 21:337-43. 2006
    ..008), the clinical significance of which was limited by between-study heterogeneity. The mechanism underlying the effect may involve serotonin and/or dopamine neurotransmission...
  41. ncbi Predicting pharmacotherapy outcome from a retrospective chart study?
    Carla de Bruijn
    J Clin Psychiatry 68:167; author reply 167-8. 2007
  42. ncbi Pitfalls in factor analytic techniques
    Femke de Geus
    Am J Psychiatry 161:579-80. 2004