Petra Denig

Summary

Affiliation: University Medical Center Groningen
Country: The Netherlands

Publications

  1. pmc The effect of a patient-oriented treatment decision aid for risk factor management in patients with diabetes (PORTDA-diab): study protocol for a randomised controlled trial
    Petra Denig
    Department of Clinical Pharmacology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands
    Trials 13:219. 2012
  2. doi request reprint Medication adherence affects treatment modifications in patients with type 2 diabetes
    Jaco Voorham
    Department of Clinical Pharmacology, Faculty of Medical Science, University Medical Center Groningen, University of Groningen, The Netherlands
    Clin Ther 33:121-34. 2011
  3. ncbi request reprint An educational programme for peer review groups to improve treatment of chronic heart failure and diabetes mellitus type 2 in general practice
    Willeke N Kasje
    Department of Clinical Pharmacology, University of Groningen, The Netherlands
    J Eval Clin Pract 12:613-21. 2006
  4. doi request reprint Identifying targets to improve treatment in type 2 diabetes; the Groningen Initiative to aNalyse Type 2 diabetes Treatment (GIANTT) observational study
    Jaco Voorham
    Department of Clinical Pharmacology, Department of Epidemiology, University Medical Center Groningen, University of Groningen, The Netherlands
    Pharmacoepidemiol Drug Saf 19:1078-86. 2010
  5. ncbi request reprint Uptake of angiotensin II receptor blockers in the treatment of hypertension
    Jacoba P Greving
    Department of Clinical Pharmacology, University Medical Center Groningen, PO Box 196, 9700, AD, Groningen, The Netherlands
    Eur J Clin Pharmacol 61:461-6. 2005
  6. ncbi request reprint [Quality of the treatment of type 2 diabetes: results from the GIANTT project 2004-2007]
    Jaco Voorham
    Universitair Medisch Centrum Groningen, Afd Klinische Farmacologie, Groningen, The Netherlands
    Ned Tijdschr Geneeskd 154:A775. 2010
  7. pmc Differential effects of comorbidity on antihypertensive and glucose-regulating treatment in diabetes mellitus--a cohort study
    Jaco Voorham
    Department of Clinical Pharmacology, Faculty of Medical Science, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    PLoS ONE 7:e38707. 2012
  8. pmc A longitudinal study examining adherence to guidelines in diabetes care according to different definitions of adequacy and timeliness
    Grigory Sidorenkov
    Department of Clinical Pharmacology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    PLoS ONE 6:e24278. 2011
  9. pmc Methods to identify the target population: implications for prescribing quality indicators
    Liana Martirosyan
    Department of Clinical Pharmacology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    BMC Health Serv Res 10:137. 2010
  10. doi request reprint Association between performance measures and glycemic control among patients with diabetes in a community-wide primary care cohort
    Grigory Sidorenkov
    Department of Clinical Pharmacology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands
    Med Care 51:172-9. 2013

Detail Information

Publications43

  1. pmc The effect of a patient-oriented treatment decision aid for risk factor management in patients with diabetes (PORTDA-diab): study protocol for a randomised controlled trial
    Petra Denig
    Department of Clinical Pharmacology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands
    Trials 13:219. 2012
    ..As secondary aim, we want to evaluate the impact of different presentation formats, and learn more from the experiences of the healthcare providers and patients with the decision aid...
  2. doi request reprint Medication adherence affects treatment modifications in patients with type 2 diabetes
    Jaco Voorham
    Department of Clinical Pharmacology, Faculty of Medical Science, University Medical Center Groningen, University of Groningen, The Netherlands
    Clin Ther 33:121-34. 2011
    ..Although adherence problems are often mentioned in surveys as a reason for not intensifying treatment, observational studies have shown inconclusive results...
  3. ncbi request reprint An educational programme for peer review groups to improve treatment of chronic heart failure and diabetes mellitus type 2 in general practice
    Willeke N Kasje
    Department of Clinical Pharmacology, University of Groningen, The Netherlands
    J Eval Clin Pract 12:613-21. 2006
    ..The aim is to evaluate the effect of the programme on adherence to treatment guidelines in general practice...
  4. doi request reprint Identifying targets to improve treatment in type 2 diabetes; the Groningen Initiative to aNalyse Type 2 diabetes Treatment (GIANTT) observational study
    Jaco Voorham
    Department of Clinical Pharmacology, Department of Epidemiology, University Medical Center Groningen, University of Groningen, The Netherlands
    Pharmacoepidemiol Drug Saf 19:1078-86. 2010
    ..Assessment of quality of cardiometabolic risk management in diabetes in primary care...
  5. ncbi request reprint Uptake of angiotensin II receptor blockers in the treatment of hypertension
    Jacoba P Greving
    Department of Clinical Pharmacology, University Medical Center Groningen, PO Box 196, 9700, AD, Groningen, The Netherlands
    Eur J Clin Pharmacol 61:461-6. 2005
    ..To examine trends in prescribing of angiotensin II receptor blockers (ARBs) as initial and second-line treatment of hypertension...
  6. ncbi request reprint [Quality of the treatment of type 2 diabetes: results from the GIANTT project 2004-2007]
    Jaco Voorham
    Universitair Medisch Centrum Groningen, Afd Klinische Farmacologie, Groningen, The Netherlands
    Ned Tijdschr Geneeskd 154:A775. 2010
    ..To describe the quality of diabetes care at the primary care level using the risk factors HbA1c, blood pressure and LDL cholesterol...
  7. pmc Differential effects of comorbidity on antihypertensive and glucose-regulating treatment in diabetes mellitus--a cohort study
    Jaco Voorham
    Department of Clinical Pharmacology, Faculty of Medical Science, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    PLoS ONE 7:e38707. 2012
    ..We hypothesized that these effects differ according to expected priority of the conditions...
  8. pmc A longitudinal study examining adherence to guidelines in diabetes care according to different definitions of adequacy and timeliness
    Grigory Sidorenkov
    Department of Clinical Pharmacology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    PLoS ONE 6:e24278. 2011
    ..We assessed quality of diabetes care by looking at single processes versus clinical pathways. In addition, we evaluated the impact of time period definitions on this quality assessment...
  9. pmc Methods to identify the target population: implications for prescribing quality indicators
    Liana Martirosyan
    Department of Clinical Pharmacology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    BMC Health Serv Res 10:137. 2010
    ..We compared these two approaches regarding the outcome of the prescribing quality assessment and their ability to identify treated and undertreated patients...
  10. doi request reprint Association between performance measures and glycemic control among patients with diabetes in a community-wide primary care cohort
    Grigory Sidorenkov
    Department of Clinical Pharmacology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands
    Med Care 51:172-9. 2013
    ..Performance measures are used for assessing quality of care. Higher performance shown by these measures is expected to reflect better care, but little is known whether they predict better patient outcomes...
  11. ncbi request reprint Determinants for the adoption of angiotensin II receptor blockers by general practitioners
    Jacoba P Greving
    Department of Clinical Pharmacology, University Medical Center Groningen, The Netherlands
    Soc Sci Med 63:2890-8. 2006
    ..Aside from determinants related to the patient population, adoption of a new drug class among Dutch GPs is still determined more by their reliance on promotional information than by their use of professional information sources...
  12. pmc Perceived barriers for treatment of chronic heart failure in general practice; are they affecting performance?
    Willeke N Kasje
    Department of Clinical Pharmacology, University Medical Center Groningen, A Deusinglaan 1, 9713 AV Groningen, The Netherlands
    BMC Fam Pract 6:19. 2005
    ....
  13. doi request reprint Comparing adverse event rates of oral blood glucose-lowering drugs reported by patients and healthcare providers: a post-hoc analysis of observational studies published between 1999 and 2011
    Liana Hakobyan
    Department of Clinical Pharmacology, University Medical Center Groningen, University of Groningen, The Netherlands
    Drug Saf 34:1191-202. 2011
    ..Several studies showed that patients report bothersome or symptomatic ADEs more frequently than providers, but no comparisons to an external reference or gold standard have been made...
  14. pmc A pilot qualitative study to explore stakeholder opinions regarding prescribing quality indicators
    Liana Martirosyan
    Department of Clinical Pharmacology, University Medical Centre Groningen, University of Groningen, Groningen, The Netherlands
    BMC Health Serv Res 12:191. 2012
    ..Knowledge regarding the opinions and preferences of all involved parties regarding prescribing quality information is important for effective use of prescribing quality indicators...
  15. pmc Trends in hyperlipidemia and hypertension management in type 2 diabetes patients from 1998-2004: a longitudinal observational study
    Jacoba P Greving
    Department of Clinical Pharmacology, University Medical Center Groningen, University of Groningen, The Netherlands
    Cardiovasc Diabetol 6:25. 2007
    ..The objective is to assess trends in risk factor treatment, and identify determinants for medication adjustments in patients with uncontrolled hypertension and/or hyperlipidemia...
  16. ncbi request reprint Claims in advertisements for antihypertensive drugs in a Dutch medical journal
    Jacoba P Greving
    Department of Clinical Pharmacology, University Medical Center Groningen, University of Groningen, The Netherlands
    J Hypertens 25:713-22. 2007
    ..Advertising claims must not conflict with the official summary of product characteristics. After a drug has been approved, new clinical evidence may become available...
  17. ncbi request reprint Physicians' attitudes towards treatment guidelines: differences between teaching and nonteaching hospitals
    Jacoba P Greving
    Department of Clinical Pharmacology, University Medical Center Groningen, A Deusinglaan 1, 9713 AV, Groningen, The Netherlands
    Eur J Clin Pharmacol 62:129-33. 2006
    ..To investigate whether physicians' attitudes towards treatment guidelines for primary and secondary care differ between teaching and nonteaching hospitals shortly before and 4 years after the guidelines' introduction...
  18. doi request reprint Is albuminuria screening and treatment optimal in patients with type 2 diabetes in primary care? Observational data of the GIANTT cohort
    Merel E Hellemons
    Department of Clinical Pharmacology, University Medical Center Groningen, Groningen, The Netherlands
    Nephrol Dial Transplant 28:706-15. 2013
    ..We evaluated guideline adherence and factors associated with albuminuria screening and treatment in T2DM patients in primary care...
  19. doi request reprint Self-reported adverse drug events and the role of illness perception and medication beliefs in ambulatory heart failure patients: A cross-sectional survey
    Ruth H E De Smedt
    Department of Clinical Pharmacology, University of Medical Center Groningen, Graduate School for Health Research SHARE, University of Groningen, The Netherlands
    Int J Nurs Stud 48:1540-50. 2011
    ..Several demographic and clinical variables have been identified as potential risk factors for ADEs but limited knowledge is available on the impact of HF patients' beliefs and perceptions on their experience of ADEs...
  20. ncbi request reprint Physician, organizational, and patient factors associated with suboptimal blood pressure management in type 2 diabetic patients in primary care
    Carel F Schaars
    Department of Clinical Pharmacology, University of Groningen, Groningen, The Netherlands
    Diabetes Care 27:123-8. 2004
    ..To assess the quality of hypertension care in patients with type 2 diabetes in general practice and identify physician, organizational, and patient factors associated with suboptimal care...
  21. pmc Do treatment quality indicators predict cardiovascular outcomes in patients with diabetes?
    Grigory Sidorenkov
    Department of Clinical Pharmacology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands Research Institute SHARE of the Graduate School of Medical Sciences, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands
    PLoS ONE 8:e78821. 2013
    ..To this end, treatment quality indicators have been developed and tested against intermediate outcomes. No studies have tested whether these treatment quality indicators also predict hard patient outcomes...
  22. doi request reprint Treatment quality indicators predict short-term outcomes in patients with diabetes: a prospective cohort study using the GIANTT database
    Grigory Sidorenkov
    Department of Clinical Pharmacology, University Medical Center Groningen, The Netherlands
    BMJ Qual Saf 22:339-47. 2013
    ..To assess whether quality indicators for treatment of cardiovascular and renal risk factors are associated with short-term outcomes in patients with diabetes...
  23. doi request reprint Development of a minimal set of prescribing quality indicators for diabetes management on a general practice level
    Liana Martirosyan
    Department of Clinical Pharmacology, University Medical Center Groningen, University of Groningen, The Netherlands
    Pharmacoepidemiol Drug Saf 21:1053-9. 2012
    ..To identify the relevant prescribing quality domains of type 2 diabetes mellitus care as a basis for the selection of a minimal set of prescribing quality indicators from a set of previously validated indicators...
  24. doi request reprint A systematic literature review: prescribing indicators related to type 2 diabetes mellitus and cardiovascular risk management
    Liana Martirosyan
    Department of Clinical Pharmacology, University Medical Centre Groningen, University of Groningen, The Netherlands
    Pharmacoepidemiol Drug Saf 19:319-34. 2010
    ..Valid prescribing indicators (PI) are needed for reliable assessment of prescribing quality. The purpose of this study is to describe the validity of existing PI for type 2 diabetes mellitus and cardiovascular risk management...
  25. doi request reprint Cross-sectional versus sequential quality indicators of risk factor management in patients with type 2 diabetes
    Jaco Voorham
    Department of Clinical Pharmacology, University Medical Center Groningen, Groningen, The Netherlands
    Med Care 46:133-41. 2008
    ..The fairness of quality assessment methods is under debate. Quality indicators incorporating the longitudinal nature of care have been advocated but their usefulness in comparison to more commonly used cross-sectional measures is not clear...
  26. ncbi request reprint Limited effect of patient and disease characteristics on compliance with hospital antimicrobial guidelines
    Peter G M Mol
    Department of Clinical Pharmacology, University Medical Centre Groningen, Netherlands
    Eur J Clin Pharmacol 62:297-305. 2006
    ..We explored to what extent patient and disease characteristics were associated with compliance with guideline recommendations for three common infections...
  27. doi request reprint Medication beliefs, treatment complexity, and non-adherence to different drug classes in patients with type 2 diabetes
    Sieta T de Vries
    Department of Clinical Pharmacology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands Electronic address
    J Psychosom Res 76:134-8. 2014
    ..To assess the relationship of patients' medication beliefs and treatment complexity with unintentional and intentional non-adherence for three therapeutic groups commonly used by patients with type 2 diabetes...
  28. doi request reprint Review: relation between quality-of-care indicators for diabetes and patient outcomes: a systematic literature review
    Grigory Sidorenkov
    University Medical Center Groningen, University of Groningen, The Netherlands
    Med Care Res Rev 68:263-89. 2011
    ..Studies performed on different levels of analysis and studies of lower quality gave similar results. For many widely used quality indicators, there is insufficient evidence that they are predictive of better patient outcomes...
  29. pmc A review of methods used in assessing non-serious adverse drug events in observational studies among type 2 diabetes mellitus patients
    Liana Hakobyan
    Department of Clinical Pharmacology, University Medical Center Groningen, University of Groningen, The Netherlands
    Health Qual Life Outcomes 9:83. 2011
    ..Better protocols are needed on how to assess adverse drug events not only in clinical trials but also in observational studies...
  30. pmc The impact of new insights and revised practice guidelines on prescribing drugs in the treatment of Type 2 diabetes mellitus
    René Lub
    Department of Clinical Pharmacology, University of Groningen, Groningen, The Netherlands
    Br J Clin Pharmacol 62:660-5. 2006
    ..The aim of this study was to investigate the impact of new insights and revised guidelines on initial and follow-up treatment with antihyperglycaemic drugs over the period 1998-2003...
  31. doi request reprint Primary prevention of major cardiovascular and cerebrovascular events with statins in diabetic patients: a meta-analysis
    Folgerdiena M de Vries
    Unit of PharmacoEpidemiology PharmacoEconomics, Department of Pharmacy, University of Groningen, Groningen, The Netherlands
    Drugs 72:2365-73. 2012
    ..Individual trials have shown varying data on the efficacy of treatment with lipid-lowering statin therapy in the primary prevention of such events in diabetes...
  32. doi request reprint The impact of perceived adverse effects on medication changes in heart failure patients
    Ruth H E De Smedt
    Department of Clinical Pharmacology, University of Groningen, The Netherlands
    J Card Fail 16:135-41.e2. 2010
    ..Given the importance of patient safety and well-being, we quantified the likelihood and type of medication changes observed after 5 possible adverse effects (AE) perceived by heart failure (HF) patients...
  33. doi request reprint Do we need individualised prescribing quality assessment? The case of diabetes treatment
    Petra Denig
    Department of Clinical Pharmacology, University of Groningen, Groningen, The Netherland
    Int J Clin Pharm 33:145-9. 2011
    ..We do recommend further development of indicators that better address subpopulations in need of adjusted treatment, such as elderly or patients with comorbidity...
  34. ncbi request reprint Physician, organisational and patient characteristics explaining the use of angiotensin converting enzyme inhibitors in heart failure treatment: a multilevel study
    Willeke N Kasje
    Department of Clinical Pharmacology, University of Groningen, A Deusinglaan 1, 9713AV, Groningen, The Netherlands
    Eur J Clin Pharmacol 61:145-51. 2005
    ..The aim was to assess the influence of physician, organisational and patient characteristics on the treatment of chronic heart failure with angiotensin converting enzyme (ACE) inhibitors in primary care...
  35. ncbi request reprint Trends in prescribing for heart failure in Dutch primary care from 1996 to 2000
    Lisa G Pont
    Drug Utilisation Studies, Department of Clinical Pharmacology, University of Groningen, The Netherlands
    Pharmacoepidemiol Drug Saf 12:327-34. 2003
    ..The aim of this study is to explore trends in primary care prescribing for chronic heart failure (CHF) over a 5-year period (1996-2000)...
  36. doi request reprint Post-approval safety issues with innovative drugs: a European cohort study
    Peter G M Mol
    Department of Clinical Pharmacology, University Medical Center Groningen, University of Groningen, FB20, P O Box 196, 9700 AD, Groningen, The Netherlands
    Drug Saf 36:1105-15. 2013
    ..For innovative, often first-in-class drugs, safety knowledge at time of approval is often even less extensive and these may require tighter scrutiny post approval...
  37. pmc Reasons of general practitioners for not prescribing lipid-lowering medication to patients with diabetes: a qualitative study
    Elisabeth Ab
    Department of Clinical Pharmacology, University Medical Centre Groningen, University of Groningen, Groningen, The Netherlands
    BMC Fam Pract 10:24. 2009
    ..Lipid-lowering medication remains underused, even in high-risk populations. The objective of this study was to determine factors underlying general practitioners' decisions not to prescribe such drugs to patients with type 2 diabetes...
  38. ncbi request reprint Influence of elevated cardiometabolic risk factor levels on treatment changes in type 2 diabetes
    Jaco Voorham
    Clinical Pharmacology, University of Groningen, Groningen, The Netherlands
    Diabetes Care 31:501-3. 2008
    ..The low overall action rates observed for blood pressure and especially lipid management cannot sufficiently be explained by the use of treatment thresholds higher than those indicated by guidelines...
  39. ncbi request reprint Does comorbidity explain trends in prescribing of newer antihypertensive agents?
    Jacoba P Greving
    Department of Clinical Pharmacology, University of Groningen, The Netherlands
    J Hypertens 22:2209-15. 2004
    ..The association between comorbidity and trends in prescribing of angiotensin-converting enzyme inhibitors (ACE-I) and angiotensin II receptor blockers (ARBs) was examined for the period 1996-2000...
  40. pmc Computerized extraction of information on the quality of diabetes care from free text in electronic patient records of general practitioners
    Jaco Voorham
    Sector F, Department of Clinical Pharmacology, Groningen, The Netherlands
    J Am Med Inform Assoc 14:349-54. 2007
    ..This study evaluated a computerized method for extracting numeric clinical measurements related to diabetes care from free text in electronic patient records (EPR) of general practitioners...
  41. ncbi request reprint Connecting pre-marketing clinical research and medical practice: opinion-based study of core issues and possible changes in drug regulation
    Nicolien F Wieringa
    Department of Social Pharmacy and Pharmacoepidemiology, University of Groningen, The Netherlands
    Int J Technol Assess Health Care 19:202-19. 2003
    ..To identify core issues that contribute to the gap between pre-marketing clinical research and practice as seen from the perspective of medical practice, as well as possible changes and potential barriers for dosing this gap...
  42. ncbi request reprint Validity of performance indicators for assessing prescribing quality: the case of asthma
    Lisa G Pont
    Department of Clinical Pharmacology, University of Groningen, The Netherlands
    Eur J Clin Pharmacol 59:833-40. 2004
    ..Indicators that are associated with sub-optimal treatment in one of the four steps of asthma management were assessed...
  43. ncbi request reprint The value of clinical judgement analysis for improving the quality of doctors' prescribing decisions
    Petra Denig
    Department of Clinical Pharmacology, Medical Faculty, University of Groningen, The Netherlands
    Med Educ 36:770-80. 2002
    ..e. on what doctors do in practice. Studies in other fields have shown that another form of feedback based on the analysis of judgements may be useful as well...