Sanne de Wit
Affiliation: University of Amsterdam
Country: The Netherlands
- Corticostriatal connectivity underlies individual differences in the balance between habitual and goal-directed action controlSanne de Wit
Amsterdam Center for the Study of Adaptive Control in Brain and Behavior, Department of Developmental Psychology, University of Amsterdam, 1018 XA Amsterdam, The Netherlands
J Neurosci 32:12066-75. 2012..These findings suggest that integrity of dissociable corticostriatal pathways underlies individual differences in action control in the healthy population, which may ultimately mediate vulnerability to impulse control disorders...
- Habitual versus goal-directed action control in Parkinson diseaseSanne de Wit
Department of Psychology, Amsterdam Center for Study of Adaptive Control in Brain and Behavior Acacia, University of Amsterdam, Roeterstraat 15, 1018 WB, The Netherlands
J Cogn Neurosci 23:1218-29. 2011..If anything our results suggest a disease severity-dependent deficit in goal-directed behavior. These results are discussed in the context of Parkinson disease and the neurobiology of habitual and goal-directed behavior...
- Differential engagement of the ventromedial prefrontal cortex by goal-directed and habitual behavior toward food pictures in humansSanne de Wit
Amsterdam Center for the Study of Adaptive Control in Brain and Behavior Acacia, Department of Psychology, University of Amsterdam, 1018 WB Amsterdam, The Netherlands
J Neurosci 29:11330-8. 2009..We can therefore exclude a purely Pavlovian account of ventromedial prefrontal function and unequivocally demonstrate its involvement in the acquisition as well as deployment of goal-directed knowledge...
- Resolution of conflict between goal-directed actions: outcome encoding and neural control processesSanne de Wit
Department of Experimental Psychology, University of Cambridge
J Exp Psychol Anim Behav Process 35:382-93. 2009..Furthermore, Experiment 2 shows that once goal-directed control has been established the dorsomedial prefrontal cortex is not directly involved in its maintenance but rather plays a central role in conflict resolution processes...
- Reliance on habits at the expense of goal-directed control following dopamine precursor depletionSanne de Wit
Behavioral and Clinical Neuroscience Institute, University of Cambridge, Cambridge, UK
Psychopharmacology (Berl) 219:621-31. 2012..Recent animal studies have implicated dopamine in the reinforcement of stimulus-response habits, as well as in flexible, goal-directed action. However, the role of dopamine in human action control is still not well understood...
- Associative theories of goal-directed behaviour: a case for animal-human translational modelsSanne de Wit
Department of Psychology, Amsterdam Center for the Study of Adaptive Control in Brain and Behavior Acacia, University of Amsterdam, Amsterdam, The Netherlands
Psychol Res 73:463-76. 2009....
- Dorsomedial prefrontal cortex resolves response conflict in ratsSanne de Wit
Department of Experimental Psychology, University of Cambridge, Cambridge CB2 3EB, United Kingdom
J Neurosci 26:5224-9. 2006..Whereas rats with a functional dmPFC are able to resolve this conflict, inactivation of dmPFC using an infusion of muscimol produced a deficit by selectively interfering with their ability to inhibit the incorrect, competing response...
- Disruption in the balance between goal-directed behavior and habit learning in obsessive-compulsive disorderClaire M Gillan
Department of Experimental Psychology and Psychiatry, University of Cambridge, Cambridge, UK
Am J Psychiatry 168:718-26. 2011..This study investigated whether the urge to perform compulsive acts is mediated by a disruption in the balance between flexible, goal-directed action control and habitual behavior...
- Neurocognitive endophenotypes of impulsivity and compulsivity: towards dimensional psychiatryTrevor W Robbins
Behavioural and Clinical Neuroscience Institute, University of Cambridge, Cambridge CB2 3EB, UK
Trends Cogn Sci 16:81-91. 2012..We argue that this approach has important implications for the future classification of psychiatric disorders, genetics and therapeutics...
- The interaction between discriminative stimuli and outcomes during instrumental learningAnthony Dickinson
Department of Experimental Psychology, University of Cambridge, Cambridge, UK
Q J Exp Psychol B 56:127-39. 2003..These results are discussed in relation to the associative structures mediating the discriminative control of instrumental performance...