Rudolf A de Boer

Summary

Affiliation: University Medical Center Groningen
Country: The Netherlands

Publications

  1. pmc New roles for renin and prorenin in heart failure and cardiorenal crosstalk
    Nicolas F Schroten
    Department of Cardiology, University Medical Center Groningen, University of Groningen, Hanzeplein 1, PO Box 30 001, 9700 RB Groningen, The Netherlands
    Heart Fail Rev 17:191-201. 2012
  2. pmc Heart failure-associated anemia: bone marrow dysfunction and response to erythropoietin
    Willem Peter T Ruifrok
    Department of Cardiology, University Medical Center Groningen, University of Groningen, Hanzeplein 1, 9713 GZ Groningen, The Netherlands
    J Mol Med (Berl) 89:377-87. 2011
  3. ncbi request reprint Genetics in heart failure: where are we headed?
    Rudolf A de Boer
    Department of Cardiology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    Congest Heart Fail 12:329-32. 2006
  4. doi request reprint Pharmacogenetics in heart failure: promises and challenges
    Rudolf A de Boer
    University Medical Centre Groningen, Thoraxcentre, Department of Cardiology, P O Box 30 001, Groningen 9700RB, The Netherlands
    Expert Opin Pharmacother 10:1713-25. 2009
  5. doi request reprint Influence of diabetes mellitus and hyperglycemia on prognosis in patients > or =70 years old with heart failure and effects of nebivolol (data from the Study of Effects of Nebivolol Intervention on Outcomes and Rehospitalization in Seniors with heart f
    Rudolf A de Boer
    Department of Cardiology, University Medical Center Groningen, The University of Groningen, Groningen, The Netherlands
    Am J Cardiol 106:78-86.e1. 2010
  6. doi request reprint Galectin-3: a novel mediator of heart failure development and progression
    Rudolf A de Boer
    Department of Cardiology, University Medical Centre Groningen, PO Box 30 001, Hanzeplein 1, 9700 RB, Groningen, The Netherlands
    Eur J Heart Fail 11:811-7. 2009
  7. pmc Galectin-3 in cardiac remodeling and heart failure
    Rudolf A de Boer
    Department of Cardiology, Division of Experimental Cardiology, University Medical Center Groningen, PO Box 30 001, Groningen, 9700 RB, The Netherlands
    Curr Heart Fail Rep 7:1-8. 2010
  8. ncbi request reprint Extracellular signal regulated kinase and SMAD signaling both mediate the angiotensin II driven progression towards overt heart failure in homozygous TGR(mRen2)27
    Rudolf A de Boer
    Thoraxcenter, Department of Cardiology, University Hospital Groningen, PO Box 30001, 9700 RB, Groningen, The Netherlands
    J Mol Med (Berl) 82:678-87. 2004
  9. pmc Renal dysfunction is associated with shorter telomere length in heart failure
    Liza S M Wong
    Department of Cardiology, University Medical Center Groningen, University of Groningen, Hanzeplein 1, Groningen, The Netherlands
    Clin Res Cardiol 98:629-34. 2009
  10. doi request reprint Inflammation and anaemia in a broad spectrum of patients with heart failure
    Lennaert Kleijn
    Department of Cardiology, University Medical Center Groningen, Groningen, The Netherlands
    Heart 98:1237-41. 2012

Detail Information

Publications82

  1. pmc New roles for renin and prorenin in heart failure and cardiorenal crosstalk
    Nicolas F Schroten
    Department of Cardiology, University Medical Center Groningen, University of Groningen, Hanzeplein 1, PO Box 30 001, 9700 RB Groningen, The Netherlands
    Heart Fail Rev 17:191-201. 2012
    ..Renin and prorenin are pivotal since these are at the base of all of these pathways...
  2. pmc Heart failure-associated anemia: bone marrow dysfunction and response to erythropoietin
    Willem Peter T Ruifrok
    Department of Cardiology, University Medical Center Groningen, University of Groningen, Hanzeplein 1, 9713 GZ Groningen, The Netherlands
    J Mol Med (Berl) 89:377-87. 2011
    ..Altogether, these results suggest that BM dysfunction is an important contributor to HF-associated anemia and that EPO is not an effective agent to treat HF-associated anemia...
  3. ncbi request reprint Genetics in heart failure: where are we headed?
    Rudolf A de Boer
    Department of Cardiology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    Congest Heart Fail 12:329-32. 2006
    ..It is expected that in the future we will be able to overcome these problems and apply the knowledge gained by genetic analyses to target and optimize treatment...
  4. doi request reprint Pharmacogenetics in heart failure: promises and challenges
    Rudolf A de Boer
    University Medical Centre Groningen, Thoraxcentre, Department of Cardiology, P O Box 30 001, Groningen 9700RB, The Netherlands
    Expert Opin Pharmacother 10:1713-25. 2009
    ..Prospective large-scale pharmacogenetic studies are warranted as we believe that they will identify new targets for therapy and specific populations that benefit from specific treatments...
  5. doi request reprint Influence of diabetes mellitus and hyperglycemia on prognosis in patients > or =70 years old with heart failure and effects of nebivolol (data from the Study of Effects of Nebivolol Intervention on Outcomes and Rehospitalization in Seniors with heart f
    Rudolf A de Boer
    Department of Cardiology, University Medical Center Groningen, The University of Groningen, Groningen, The Netherlands
    Am J Cardiol 106:78-86.e1. 2010
    ..Nebivolol was less effective in the patients with diabetes and HF than in those with HF but without diabetes who were > or =70 years old...
  6. doi request reprint Galectin-3: a novel mediator of heart failure development and progression
    Rudolf A de Boer
    Department of Cardiology, University Medical Centre Groningen, PO Box 30 001, Hanzeplein 1, 9700 RB, Groningen, The Netherlands
    Eur J Heart Fail 11:811-7. 2009
    ..This review summarizes the most recent advances in galectin-3 research, with an emphasis on the role galectin-3 plays in the development and progression of HF...
  7. pmc Galectin-3 in cardiac remodeling and heart failure
    Rudolf A de Boer
    Department of Cardiology, Division of Experimental Cardiology, University Medical Center Groningen, PO Box 30 001, Groningen, 9700 RB, The Netherlands
    Curr Heart Fail Rep 7:1-8. 2010
    ..Future studies should focus on galectin-3 biology to better address the usefulness of galectin-3 as a biomarker and probe the usefulness of anti-galectin-3 therapy in treating heart failure...
  8. ncbi request reprint Extracellular signal regulated kinase and SMAD signaling both mediate the angiotensin II driven progression towards overt heart failure in homozygous TGR(mRen2)27
    Rudolf A de Boer
    Thoraxcenter, Department of Cardiology, University Hospital Groningen, PO Box 30001, 9700 RB, Groningen, The Netherlands
    J Mol Med (Berl) 82:678-87. 2004
    ..This process is prevented by both AT1 receptor blockade and TYR, and therefore inhibition of either pathway is equally efficacious in restoring LV function and architecture...
  9. pmc Renal dysfunction is associated with shorter telomere length in heart failure
    Liza S M Wong
    Department of Cardiology, University Medical Center Groningen, University of Groningen, Hanzeplein 1, Groningen, The Netherlands
    Clin Res Cardiol 98:629-34. 2009
    ..We explored the association between leukocyte telomere length, a marker for biological age, and renal function in patients with CHF...
  10. doi request reprint Inflammation and anaemia in a broad spectrum of patients with heart failure
    Lennaert Kleijn
    Department of Cardiology, University Medical Center Groningen, Groningen, The Netherlands
    Heart 98:1237-41. 2012
    ..Although inflammation is assumed to be an important cause of anaemia, the association between anaemia and inflammatory markers in patients with HF has not been well established...
  11. doi request reprint Erythropoietin stimulates normal endothelial progenitor cell-mediated endothelial turnover, but attributes to neovascularization only in the presence of local ischemia
    B Daan Westenbrink
    Department of Cardiology, Thoraxcenter, University Medical Center Groningen, Hanzeplein 1, P O Box 30001, 9700 RB Groningen, The Netherlands
    Cardiovasc Drugs Ther 22:265-74. 2008
    ..We aimed to evaluate whether ischemia is required for erythropoietin (EPO) induced stimulation of endothelial progenitor cells (EPCs) and their related effects on endothelial and cardiac function...
  12. ncbi request reprint Vascular endothelial growth factor is crucial for erythropoietin-induced improvement of cardiac function in heart failure
    B Daan Westenbrink
    Department of Cardiology, Thoraxcenter, University Medical Center Groningen, University of Groningen, Hanzeplein 1, PO Box 30001, Groningen 9700 RB, The Netherlands
    Cardiovasc Res 87:30-9. 2010
    ..We intended to delineate the mechanisms of erythropoietin (EPO)-induced cardiac vascular endothelial growth factor (VEGF) production and to establish if VEGF is crucial for EPO-induced improvement of cardiac performance...
  13. ncbi request reprint Induction of kidney injury molecule-1 in homozygous Ren2 rats is attenuated by blockade of the renin-angiotensin system or p38 MAP kinase
    Martin H de Borst
    Dept of Pathology and Laboratory Medicine, Univ Medical Center Groningen and Univ of Groningen, PO Box 30 001, 9700 RB Groningen, The Netherlands
    Am J Physiol Renal Physiol 292:F313-20. 2007
    ..01). Kim-1 is associated with development of RAS-mediated renal damage. Antifibrotic treatment through RAS blockade or p38 MAP kinase inhibition reduced Kim-1 in the homozygous Ren2 model...
  14. doi request reprint Plasma renin and outcome in the community: data from PREVEND
    Rudolf A de Boer
    Department of Cardiology, University of Groningen, University Medical Centre Groningen, Hanzeplein 1, Groningen 9713GZ, The Netherlands
    Eur Heart J 33:2351-9. 2012
    ..The renin-angiotensin system plays a central role in patients with established cardiovascular (CV) disease, but the prognostic effect of plasma renin in the community is unclear...
  15. doi request reprint The vitamin D receptor activator paricalcitol prevents fibrosis and diastolic dysfunction in a murine model of pressure overload
    Laura M G Meems
    Department of Cardiology, University of Groningen, University Medical Center Groningen, P O Box 30 001, Postal code AB43, 9700 RB Groningen, The Netherlands
    J Steroid Biochem Mol Biol 132:282-9. 2012
    ..We hypothesized that activation of the VDR by paricalcitol would prevent fibrosis and LV diastolic dysfunction in an established murine model of cardiac remodeling...
  16. doi request reprint Metformin improves cardiac function in a nondiabetic rat model of post-MI heart failure
    Meimei Yin
    University Medical Center Groningen, Thorax Center, Department of Cardiology, University of Groningen, The Netherlands
    Am J Physiol Heart Circ Physiol 301:H459-68. 2011
    ..Altogether our results indicate that metformin may have potential to attenuate heart failure development after myocardial infarction, in the absence of diabetes and independent of systemic glucose levels...
  17. doi request reprint Anaemia is associated with shorter leucocyte telomere length in patients with chronic heart failure
    Liza S M Wong
    Department of Cardiology, University Medical Center Groningen, University of Groningen, Hanzeplein 1, Groningen, The Netherlands
    Eur J Heart Fail 12:348-53. 2010
    ..We hypothesize that short telomere length contributes to the susceptibility to develop anaemia in patients with CHF...
  18. doi request reprint Genome-wide association study on plasma levels of midregional-proadrenomedullin and C-terminal-pro-endothelin-1
    Niek Verweij
    Department of Cardiology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands
    Hypertension 61:602-8. 2013
    ..The discovery of genetic variants in the kallikrein-kinin system and in the genes encoding pre-pro-ET-1 and pre-pro-ADM provides novel insights into the (co-)regulation of these vasoactive peptides in the vascular system...
  19. doi request reprint Circulating leukocyte and carotid atherosclerotic plaque telomere length: interrelation, association with plaque characteristics, and restenosis after endarterectomy
    Jardi Huzen
    University Medical Centre Groningen, Department of Cardiology, University of Groningen, Hanzeplein 1, PO Box 9700 RB Groningen, The Netherlands
    Arterioscler Thromb Vasc Biol 31:1219-25. 2011
    ..The goal of the present study was to determine whether leukocyte telomere length is related to atherosclerotic plaque telomere length and whether it is associated with plaque characteristics or recurrence of disease...
  20. pmc Gaseous hydrogen sulfide protects against myocardial ischemia-reperfusion injury in mice partially independent from hypometabolism
    Pauline M Snijder
    Department of Pathology and Medical Biology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands
    PLoS ONE 8:e63291. 2013
    ..We investigated whether gaseous H2S administration is protective in cardiac IRI and whether non-hypometabolic concentrations of H2S have similar protective properties...
  21. doi request reprint Incidence and epidemiology of new onset heart failure with preserved vs. reduced ejection fraction in a community-based cohort: 11-year follow-up of PREVEND
    Frank P Brouwers
    Department of Cardiology, University Medical Center Groningen, University of Groningen, PO Box 30 001, Hanzeplein 1, 9713 GZ Groningen, The Netherlands
    Eur Heart J 34:1424-31. 2013
    ..Data on epidemiology and prediction of new onset HFpEF, compared with HFrEF, have not been described...
  22. doi request reprint Prognostic value of changes in galectin-3 levels over time in patients with heart failure: data from CORONA and COACH
    A Rogier van der Velde
    Department of Cardiology, Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    Circ Heart Fail 6:219-26. 2013
    ..The importance and clinical use of repeated measurements of galectin-3 have not yet been reported...
  23. doi request reprint Genetic and pharmacological inhibition of galectin-3 prevents cardiac remodeling by interfering with myocardial fibrogenesis
    Lili Yu
    Department of Cardiology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    Circ Heart Fail 6:107-17. 2013
    ..Galectin-3 has been implicated in the development of organ fibrosis. It is unknown whether it is a relevant therapeutic target in cardiac remodeling and heart failure...
  24. doi request reprint Renal effects of long-term darbepoetin alpha treatment in hypertensive TGR(mRen2)27 rats
    Anne Roos S Frenay
    Department of Pathology and Medical Biology, University Medical Center Groningen and University of Groningen, Groningen, The Netherlands
    J Renin Angiotensin Aldosterone Syst 13:232-8. 2012
    ..Since the development of renal interstitial abnormalities are often associated with ischaemia, we studied the effects of the long-acting EPO analogue darbepoetin alpha (DA) on kidney damage in TGR(mRen2)27 (Ren2) rats...
  25. doi request reprint Telomere length and psychological well-being in patients with chronic heart failure
    Jardi Huzen
    Department of Cardiology, University Medical Center Groningen, Hanzeplein 1, 9700 RB Groningen, The Netherlands
    Age Ageing 39:223-7. 2010
    ..Shorter telomere length indicates a more advanced biological age. It is unknown whether psychological well-being is associated with telomere length in patients with the somatic condition of chronic heart failure (CHF)...
  26. pmc AKIP1, a cardiac hypertrophy induced protein that stimulates cardiomyocyte growth via the Akt pathway
    Hongjuan Yu
    Department of Cardiology, University Medical Center Groningen, University of Groningen, Hanzeplein 1, 9713 GZ Groningen, P O Box 30 001, Groningen 9700 RB, The Netherlands
    Int J Mol Sci 14:21378-93. 2013
    ..In conclusion, our results show that AKIP1 is induced in hypertrophic hearts and can stimulate adaptive cardiomyocyte growth, which involves Akt signaling. ..
  27. doi request reprint Bone marrow dysfunction in chronic heart failure patients
    B Daan Westenbrink
    Department of Cardiology, Thoraxcenter, University Medical Center Groningen, Hanzeplein 1, PO Box 30001, Groningen 9700 RB, The Netherlands
    Eur J Heart Fail 12:676-84. 2010
    ..To investigate whether chronic heart failure (CHF) is associated with a general dysfunction of the haematopoietic compartment...
  28. doi request reprint Vitamin D status and outcomes in heart failure patients
    Licette C Y Liu
    Department of Cardiology, University Medical Center Groningen, University of Groningen, The Netherlands
    Eur J Heart Fail 13:619-25. 2011
    ..The aims of this study were to determine whether a low vitamin D status is associated with prognosis in HF and whether activation of the renin-angiotensin system (RAS) and inflammatory markers could explain this potential association...
  29. doi request reprint Suicidal erythrocyte death, eryptosis, as a novel mechanism in heart failure-associated anaemia
    Hasan Mahmud
    Department of Cardiology, University Medical Center Groningen, University of Groningen, Hanzeplein 1, Groningen 9713 GZ, The Netherlands
    Cardiovasc Res 98:37-46. 2013
    ..Excessive eryptosis may lead to anaemia. We aimed to study the role of eryptosis in heart failure (HF)-associated anaemia...
  30. pmc Metformin in non-diabetic patients presenting with ST elevation myocardial infarction: rationale and design of the glycometabolic intervention as adjunct to primary percutaneous intervention in ST elevation myocardial infarction (GIPS)-III trial
    Chris P H Lexis
    Department of Cardiology, University Medical Center Groningen, University of Groningen, Hanzeplein 1, 9700 RB, PO Box 30 001, Groningen, The Netherlands
    Cardiovasc Drugs Ther 26:417-26. 2012
    ..We will study the efficacy of metformin with the aim to preserve left ventricular ejection fraction in non-diabetic patients presenting with ST elevation myocardial infarction (STEMI)...
  31. doi request reprint Influence of age on the prognostic value of mid-regional pro-adrenomedullin in the general population
    Frank P Brouwers
    Department of Cardiology, University Medical Center Groningen, University of Groningen, The Netherlands
    Heart 98:1348-53. 2012
    ..The aim of this study was to evaluate the prognostic performance of MR-proADM in the general population, controlling for these potential confounders...
  32. doi request reprint Possible association between telomere length and renal dysfunction in patients with chronic heart failure
    Pim van der Harst
    Department of Cardiology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    Am J Cardiol 102:207-10. 2008
    ..Further studies will be needed to determine whether shorter leukocyte telomere length is the cause or consequence in this population and whether it plays a role in the prognosis of renal dysfunction in HF...
  33. ncbi request reprint Nebivolol: third-generation beta-blockade
    Rudolf A de Boer
    University Medical Center Groningen, Thoraxcenter, Department of Cardiology, Groningen, The Netherlands
    Expert Opin Pharmacother 8:1539-50. 2007
    ..This review describes experimental and clinical data regarding this selective beta-blocker with vasodilating and antioxidant effects...
  34. ncbi request reprint Erythropoietin improves left ventricular function and coronary flow in an experimental model of ischemia-reperfusion injury
    Peter van der Meer
    Department of Cardiology, University Hospital Groningen, Groningen, The Netherlands
    Eur J Heart Fail 6:853-9. 2004
    ..Recently, it has been shown that in patients with chronic heart failure (CHF), EPO treatment improved cardiac function. In the present study we assessed the role of EPO and EPO-receptor (EPO-R) in the heart...
  35. doi request reprint Erythropoietin in cardiac disease: new features of an old drug
    Willem Peter T Ruifrok
    Department of Cardiology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    Eur J Pharmacol 585:270-7. 2008
    ....
  36. doi request reprint Telomere length and outcome in heart failure
    Pim van der Harst
    Department of Cardiology, University Medical Center Groningen, University of Groningen, Hanzeplein 1, 9700 RB Groningen, The Netherlands
    Ann Med 42:36-44. 2010
    ..Senescence is a potential factor in the pathogenesis and progression of heart failure. In heart failure telomeres are shorter, but the prognostic value associated with telomere length has not been defined...
  37. pmc Aging, telomeres and heart failure
    Liza S M Wong
    Division of Experimental Cardiology, Department of Cardiology, University Medical Center Groningen, University of Groningen, Hanzeplein 1, 9700 RB Groningen, The Netherlands
    Heart Fail Rev 15:479-86. 2010
    ..In this review, we will elaborate on the current knowledge of aging of the heart, telomere biology and its potential role in the development of heart failure...
  38. ncbi request reprint Glucagon-like peptide 1 prevents reactive oxygen species-induced endothelial cell senescence through the activation of protein kinase A
    Hisko Oeseburg
    Department of Cardiology, University Medical Center Groningen, University of Groningen, Antonius Deusinglaan 1, 9713AV Groningen, The Netherlands
    Arterioscler Thromb Vasc Biol 30:1407-14. 2010
    ..Here we investigated whether the antidiabetic hormone glucagon-like peptide 1 (GLP-1) could prevent oxidative stress-induced cellular senescence in endothelial cells...
  39. ncbi request reprint Increased expression of cardiac angiotensin II type 1 (AT(1)) receptors decreases myocardial microvessel density after experimental myocardial infarction
    Rudolf A de Boer
    Thoraxcenter, Department of Cardiology, Hanzeplein 1, 9713 GZ, PO Box 30 001, 9700 RB, University Hospital, Groningen, The Netherlands
    Cardiovasc Res 57:434-42. 2003
    ..To study the effects of increased levels of myocardial angiotensin II type 1 (AT(1)) receptor on microvascular growth following myocardial infarction (MI)...
  40. ncbi request reprint Telomere length of circulating leukocytes is decreased in patients with chronic heart failure
    Pim van der Harst
    Department of Cardiology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    J Am Coll Cardiol 49:1459-64. 2007
    ..This study sought to test the hypothesis that patients with chronic heart failure (CHF) have shorter telomeres compared with age-balanced and gender-balanced healthy individuals...
  41. doi request reprint Sustained postoperative anaemia is associated with an impaired outcome after coronary artery bypass graft surgery: insights from the IMAGINE trial
    B Daan Westenbrink
    Department of Cardiology, Thoraxcenter, University Medical Center Groningen, Hanzeplein 1, P O Box 30001, Groningen 9700 RB, The Netherlands
    Heart 97:1590-6. 2011
    ..To investigate the association between sustained postoperative anaemia and outcome after coronary artery bypass graft (CABG) surgery...
  42. ncbi request reprint The VEGF +405 CC promoter polymorphism is associated with an impaired prognosis in patients with chronic heart failure: a MERIT-HF substudy
    Peter van der Meer
    Department of Cardiology, University Hospital Groningen, Hanzeplein 1, 9700 RB Groningen, The Netherlands
    J Card Fail 11:279-84. 2005
    ..We investigated the association between two VEGF polymorphisms and morbidity and mortality in patients with CHF...
  43. doi request reprint Activation of liver X receptor-alpha reduces activation of the renal and cardiac renin-angiotensin-aldosterone system
    Irma Kuipers
    Department of Experimental Cardiology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    Lab Invest 90:630-6. 2010
    ..In conclusion, LXR-alpha activation blunts ISO-induced increases in mRNA expression of renin, AT(1)R and ACE in the heart and kidney. These findings suggest a role for LXR-alpha in RAAS regulation...
  44. doi request reprint Cyclical stretch induces structural changes in atrial myocytes
    Anne Margreet de Jong
    Department of Cardiology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    J Cell Mol Med 17:743-53. 2013
    ..This model can contribute to investigating the mechanisms involved in the remodelling process caused by stretch and to the testing of pharmaceutical agents...
  45. doi request reprint Short-term vitamin D3 supplementation lowers plasma renin activity in patients with stable chronic heart failure: an open-label, blinded end point, randomized prospective trial (VitD-CHF trial)
    Nicolas F Schroten
    Department of Cardiology, University Medical Centre Groningen, University of Groningen, Groningen, The Netherlands
    Am Heart J 166:357-364.e2. 2013
    ..Vitamin D may inhibit renin transcription and lower PRA. We investigated whether vitamin D3 (VitD3) supplementation lowers PRA in CHF patients...
  46. doi request reprint Left-dominant arrhythmogenic cardiomyopathy in a large family: associated desmosomal or nondesmosomal genotype?
    Judith A Groeneweg
    Department of Cardiology, University Medical Center Utrecht and Interuniversity Cardiology Institute of the Netherlands, Utrecht, The Netherlands
    Heart Rhythm 10:548-59. 2013
    ..419C>T, have been described. Recently, a nondesmosomal phospholamban (PLN) mutation (c.40_42delAGA) has been identified, causing dilated cardiomyopathy and arrhythmias...
  47. pmc A genome-wide association study of circulating galectin-3
    Rudolf A de Boer
    Department of Cardiology, University of Groningen, University Medical Center Groningen, The Netherlands
    PLoS ONE 7:e47385. 2012
    ..97 × 10(-465) and rs4652 P = 1.50 × 10(-421)) and were also associated with LGALS3 gene-expression. The origins of our associations should be further validated by means of functional experiments...
  48. pmc Early and late effects of the DPP-4 inhibitor vildagliptin in a rat model of post-myocardial infarction heart failure
    Meimei Yin
    University Medical Center Groningen, University of Groningen, Department of Cardiology, Groningen, The Netherlands
    Cardiovasc Diabetol 10:85. 2011
    ..We hypothesized that the DPP-4 inhibitor vildagliptin will increase levels of GLP-1 and may exert protective effects on cardiac function after MI...
  49. doi request reprint Activation of liver X receptors with T0901317 attenuates cardiac hypertrophy in vivo
    Irma Kuipers
    Department of Experimental Cardiology, University Medical Center Groningen, PO Box 30 001, 9700 RB Groningen, The Netherlands
    Eur J Heart Fail 12:1042-50. 2010
    ..Liver X receptor has also been shown to exert anti-proliferative and anti-inflammatory properties. In this study, we evaluated the effect of LXR activation on cardiac hypertrophy in vitro and in vivo...
  50. pmc Predictive value of plasma galectin-3 levels in heart failure with reduced and preserved ejection fraction
    Rudolf A de Boer
    Department of Cardiology, University Medical Centre Groningen, University of Groningen, PO Box 30 001, Hanzeplein 1, 9700 RB, Groningen, The Netherlands
    Ann Med 43:60-8. 2011
    ..We studied the prognostic value of base-line galectin-3 in a large HF cohort, with preserved and reduced left ventricular ejection fraction (LVEF), and compared this to other biomarkers...
  51. doi request reprint Telomere biology in cardiovascular disease: the TERC-/- mouse as a model for heart failure and ageing
    Liza S M Wong
    Department of Cardiology, University Medical Center Groningen, University of Groningen, Hanzeplein 1, 9700RB Groningen, The Netherlands
    Cardiovasc Res 81:244-52. 2009
    ..The TERC(-/-) mice provide exciting opportunities to expand our knowledge of telomere biology in cardiovascular disease and the potential identification of novel targets of treatment...
  52. doi request reprint Prognostic value of renin and prorenin in heart failure patients with decreased kidney function
    Mariusz K Szymanski
    Department of Cardiology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    Am Heart J 162:487-93. 2011
    ..We aimed to investigate the prognostic value of active plasma renin concentration (APRC) and prorenin in patients with HF treated with RAAS-blocking agents and its relationship with kidney function parameters...
  53. ncbi request reprint Anemia is associated with an increased central venous pressure and mortality in a broad spectrum of cardiovascular patients
    Lennaert Kleijn
    Department of Cardiology, Thoraxcenter, University Medical Center Groningen, University of Groningen, Hanzeplein 1, P O Box 30001, 9700 RB, Groningen, The Netherlands
    Clin Res Cardiol 103:467-76. 2014
    ..Therefore, we investigated the association between hemoglobin (Hb) levels, hemodynamics and outcome in a broad spectrum of cardiovascular patients...
  54. doi request reprint Regulation of the (pro)renin-renin receptor in cardiac remodelling
    Hasan Mahmud
    University Medical Center Groningen, Thorax Center, Department of Cardiology, University of Groningen, The Netherlands
    J Cell Mol Med 16:722-9. 2012
    ..These results demonstrate that (P)RR expression is strongly up-regulated both in rodent models of heart failure and in the failing human heart, hinting to a potential role for (P)RR in cardiac pathophysiology...
  55. ncbi request reprint The emerging role of telomere biology in cardiovascular disease
    Jardi Huzen
    Department of Cardiology, University Medical Centre Groningen, University of Groningen, Hanzeplein 1, 9700 RB Groningen, The Netherlands
    Front Biosci (Landmark Ed) 15:35-45. 2010
    ..If telomeres can be proven to be not only associated but also causally involved in the pathogenesis of cardiovascular disease it might provide exciting new avenues for the development of future preventive and therapeutic strategies...
  56. pmc Telomere length of circulating leukocyte subpopulations and buccal cells in patients with ischemic heart failure and their offspring
    Liza S M Wong
    Department of Cardiology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    PLoS ONE 6:e23118. 2011
    ..We additionally measured TL of offspring of patients and controls to examine heritability throughout different cell types...
  57. doi request reprint Erythropoiesis stimulation in acute ischemic syndromes
    Willem Peter T Ruifrok
    Department of Cardiology, University Medical Center Groningen, University of Groningen, PO Box 30 001, 9700 RB Groningen, The Netherlands
    Heart Fail Clin 6:313-21. 2010
    ..Large, randomized, placebo-controlled clinical trials are underway to give a final verdict on EPO treatment for acute coronary syndromes...
  58. doi request reprint Anemia in chronic heart failure: etiology and treatment options
    B Daan Westenbrink
    Department of Cardiology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    Curr Opin Cardiol 23:141-7. 2008
    ..The review will describe current advances in the understanding of the pathophysiology of anemia and the potential therapeutic effects of recombinant human erythropoietin...
  59. ncbi request reprint Effect of metformin on left ventricular function after acute myocardial infarction in patients without diabetes: the GIPS-III randomized clinical trial
    Chris P H Lexis
    University of Groningen, University Medical Center Groningen, Department of Cardiology, Groningen, The Netherlands
    JAMA 311:1526-35. 2014
    ..Metformin treatment is associated with improved outcome after myocardial infarction in patients with diabetes. In animal experimental studies metformin preserves left ventricular function...
  60. pmc Cardiac function and architecture are maintained in a model of cardiorestricted overexpression of the prorenin-renin receptor
    Hasan Mahmud
    University of Groningen, University Medical Center Groningen, Department of Cardiology, Groningen, The Netherlands
    PLoS ONE 9:e89929. 2014
    ..It is concluded that increased myocardial (P)RR expression is unlikely to have a major role in pathological cardiac remodeling...
  61. pmc Seventy-five genetic loci influencing the human red blood cell
    Pim van der Harst
    Department of Cardiology, University of Groningen, University Medical Center Groningen, 9700 RB Groningen, The Netherlands
    Nature 492:369-75. 2012
    ..Our findings provide extensive new insights into genetic mechanisms and biological pathways controlling red blood cell formation and function...
  62. doi request reprint Identification of hypertrophy- and heart failure-associated genes by combining in vitro and in vivo models
    Bo Lu
    Department of Cardiology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    Physiol Genomics 44:443-54. 2012
    ..Moreover it provides insight in the differences between the different etiology models and neurohormonal effects...
  63. doi request reprint Replication of the five novel loci for uric acid concentrations and potential mediating mechanisms
    Pim van der Harst
    Department of Cardiology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    Hum Mol Genet 19:387-95. 2010
    ..011), fractional UA excretion (P = 3.36 x 10(-5)) and high-sensitive CRP (P = 1.18 x 10(-3)) also after adjusting for serum UA levels. We argue that GCKR locus affects serum UA levels through a factor that also affects triglycerides...
  64. doi request reprint Telomere biology in heart failure
    Liza S M Wong
    Department of Cardiology, University Medical Center Groningen, University of Groningen, Groningen, Hanzeplein 1, 9700 RB Groningen, The Netherlands
    Eur J Heart Fail 10:1049-56. 2008
    ..In heart failure, telomere length is severely reduced. In the current review, we will discuss the emerging role of telomere biology in the pathophysiology of heart failure...
  65. doi request reprint Nuclear hormone receptors as regulators of the renin-angiotensin-aldosterone system
    Irma Kuipers
    Department of Cardiology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    Hypertension 51:1442-8. 2008
  66. pmc A role for CETP TaqIB polymorphism in determining susceptibility to atrial fibrillation: a nested case control study
    Folkert W Asselbergs
    Department of Cardiology, University Medical Center Groningen, Groningen, The Netherlands
    BMC Med Genet 7:39. 2006
    ..We aimed to investigate the association between several environmental factors and loci of candidate genes, which might be related to the presence of AF...
  67. pmc Telomere biology in healthy aging and disease
    Hisko Oeseburg
    Department of Cardiology, University Medical Center Groningen, University of Groningen, Hanzeplein 1, 9700RB Groningen, The Netherlands
    Pflugers Arch 459:259-68. 2010
    ..In the current review, we will discuss the role of telomere biology in relation to aging and aging associated diseases...
  68. pmc Animal models of cardiorenal syndrome: a review
    Mariusz K Szymanski
    Department of Cardiology, University Medical Center Groningen, Groningen, The Netherlands
    Heart Fail Rev 17:411-20. 2012
    ..Finally, we propose several requirements that a new animal model should meet to serve as a tool for studies on the cardiorenal syndrome...
  69. doi request reprint Long-term effects of fosinopril and pravastatin on cardiovascular events in subjects with microalbuminuria:Ten years of follow-up of Prevention of Renal and Vascular End-stage Disease Intervention Trial (PREVEND IT)
    Frank P Brouwers
    Department of Cardiology, Thoraxcenter, Universitair Medical Center Groningen, University of Groningen, The Netherlands
    Am Heart J 161:1171-8. 2011
    ..We obtained extended follow-up data to approximately 10 years to investigate the long-term effects of fosinopril 20 mg and pravastatin 40 mg on cardiovascular outcomes in subjects with UAE >15 mg per 24 hours...
  70. ncbi request reprint Vitamin D deficiency: universal risk factor for multifactorial diseases?
    Martin H de Borst
    Departments of Nephrology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    Curr Drug Targets 12:97-106. 2011
    ..Further exploration of the multifaceted actions of vitamin D may pave the way for disease-overriding intervention strategies...
  71. ncbi request reprint Rapid bedside measurement of brain natriuretic peptide in patients with chronic heart failure
    Geert Tjeerdsma
    Department of Cardiology Thoraxcentre, University Hospital Groningen, P O Box 30 001, The Netherlands
    Int J Cardiol 86:143-9; discussion 149-52. 2002
    ..We compared a new, rapid, BNP assay with a conventional BNP measurement and evaluated the applicability to current practice by comparing it with standard clinical parameters...
  72. doi request reprint The cardioprotective effects of metformin
    Saloua El Messaoudi
    Department of Pharmacology Toxicology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Curr Opin Lipidol 22:445-53. 2011
    ..It has been suggested that metformin might exert direct protective effects on the heart...
  73. ncbi request reprint Universal risk factors for multifactorial diseases: LifeLines: a three-generation population-based study
    Ronald P Stolk
    Department of Epidemiology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    Eur J Epidemiol 23:67-74. 2008
    ..LifeLines will contribute to the understanding of how universal risk factors are modified to influence the individual susceptibility to multifactorial diseases, not only at one stage of life but cumulatively over time: the lifeline...
  74. ncbi request reprint The imbalance between oxygen demand and supply as a potential mechanism in the pathophysiology of heart failure: the role of microvascular growth and abnormalities
    Rudolf A de Boer
    The Department of Cardiology, University Hospital, Thoraxcenter, Groningen, The Netherlands
    Microcirculation 10:113-26. 2003
    ..Therapies aimed at the restoration of the microcirculation are proposed to preserve and improve myocardial function...
  75. pmc Diabetes, glycemic control, and new-onset heart failure in patients with stable coronary artery disease: data from the heart and soul study
    Joost P van Melle
    Department of Cardiology, Thoraxcenter, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    Diabetes Care 33:2084-9. 2010
    ..Diabetes is a predictor of both coronary artery disease (CAD) and heart failure. It is unknown to what extent the association between diabetes and heart failure is influenced by other risk factors for heart failure...
  76. ncbi request reprint Both antiplatelet and anticoagulant therapy may favorably affect outcome in patients with advanced heart failure. A retrospective analysis of the PRIME-II trial
    Rudolf A de Boer
    Department of Cardiology, University Hospital Groningen, P O Box 30 001, 9700 RM, Groningen, The Netherlands
    Thromb Res 116:279-85. 2005
    ..We performed a post-hoc analysis to evaluate the effect of the use of anti-thrombotic therapy with APT and OAC...
  77. pmc The Plk1 inhibitor BI 2536 temporarily arrests primary cardiac fibroblasts in mitosis and generates aneuploidy in vitro
    Bo Lu
    Department of Cardiology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    PLoS ONE 5:e12963. 2010
    ..In conclusion, cardiomyocytes could be enriched using BI 2536, but the formation of aneuploidy in proliferating cells most likely limits this in vitro application and does not allow its use in putative cell based therapies...
  78. pmc Pharmacoepigenetics in heart failure
    Irene Mateo Leach
    Department of Cardiology, University Medical Center Groningen, University of Groningen, 9700RB Groningen, The Netherlands
    Curr Heart Fail Rep 7:83-90. 2010
    ..In this review, we discuss recent evidence of epigenetic changes that play an important role in the development of cardiac hypertrophy and heart failure and may dictate response to therapy...
  79. doi request reprint DHRS7c, a novel cardiomyocyte-expressed gene that is down-regulated by adrenergic stimulation and in heart failure
    Bo Lu
    Department of Cardiology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    Eur J Heart Fail 14:5-13. 2012
    ..Here we screened for gene expression profiles correlated to heart failure...
  80. doi request reprint Estradiol-induced, endothelial progenitor cell-mediated neovascularization in male mice with hind-limb ischemia
    Willem Peter T Ruifrok
    Department of Cardiology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    Vasc Med 14:29-36. 2009
    ....
  81. ncbi request reprint Specific MAP-kinase blockade protects against renal damage in homozygous TGR(mRen2)27 rats
    Martin H de Borst
    Departments of Pathology and Laboratory Medicine, University Hospital Groningen, Groningen, The Netherlands
    Lab Invest 83:1761-70. 2003
    ..In homozygous Ren2 rats, renal damage was ameliorated by a nonhypotensive dose of an AT(1)-RA and, similarly, by blockade of ERK or p38. This suggests that ERK and p38 are involved in AngII-mediated renal damage...
  82. ncbi request reprint Efficacy of angiotensin II type 1 receptor blockade on reperfusion-induced arrhythmias and mortality early after myocardial infarction is increased in transgenic rats with cardiac angiotensin II type 1 overexpression
    Rudolf A de Boer
    Thoraxcenter, Department of Cardiology, University Hospital Groningen, P O Box 30 001, Groningen, The Netherlands
    J Cardiovasc Pharmacol 39:610-9. 2002
    ..05). A smaller, nonsignificant effect was observed in SD rats (63% to 81%). AT1R blockade is beneficial only when the AT1R was overexpressed, both in reducing the reperfusion-induced arrhythmias and mortality early after MI...