Philip G de Groot

Summary

Affiliation: University Medical Center Utrecht
Country: The Netherlands

Publications

  1. doi request reprint A heparin-bonded vascular graft generates no systemic effect on markers of hemostasis activation or detectable heparin-induced thrombocytopenia-associated antibodies in humans
    Jan M M Heyligers
    Department of Vascular Surgery, University Medical Center Utrecht, Utrecht, The Netherlands
    J Vasc Surg 47:324-9; discussion 329. 2008
  2. doi request reprint The significance of autoantibodies against β2-glycoprotein I
    Philip G de Groot
    Department of Clinical Chemistry and Haematology, University Medical Center, Heidelberglaan 100, Utrecht, The Netherlands
    Blood 120:266-74. 2012
  3. doi request reprint Pathophysiology of thrombotic APS: where do we stand?
    P G de Groot
    Department of Clinical Chemistry and Haematology, University Medical Center, Utrecht, The Netherlands
    Lupus 21:704-7. 2012
  4. doi request reprint The future of antiphospholipid antibody testing
    Philip G de Groot
    Department of Clinical Chemistry and Haematology, University Medical Center, Heidelberglaan 100, Utrecht, The Netherlands
    Semin Thromb Hemost 38:412-20. 2012
  5. doi request reprint Recent developments in our understanding of the antiphospholipid syndrome
    P G de Groot
    Department of Clinical Chemistry and Haematology, University Medical Center, Utrecht, The Netherlands
    Int J Lab Hematol 34:223-31. 2012
  6. doi request reprint The role of LRP8 (ApoER2') in the pathophysiology of the antiphospholipid syndrome
    P G de Groot
    Department of Clinical Chemistry and Haematology, University Medical Center, Utrecht, The Netherlands
    Lupus 19:389-93. 2010
  7. doi request reprint Mechanisms of anti-phospholipid antibody formation and action
    Philip G de Groot
    University Medical Centre, Department of Clinical Chemistry and Haematology, Utrecht, The Netherlands
    Thromb Res 127:S40-2. 2011
  8. doi request reprint β(2) -Glycoprotein I: evolution, structure and function
    P G de Groot
    Department of Clinical Chemistry and Hematology, University Medical Center, Utrecht, The Netherlands
    J Thromb Haemost 9:1275-84. 2011
  9. doi request reprint Twenty-two years of failure to set up undisputed assays to detect patients with the antiphospholipid syndrome
    Philip G de Groot
    Department of Clinical Chemistry and Haematology, University Medical Centre, Utrecht, Germany
    Semin Thromb Hemost 34:347-55. 2008
  10. ncbi request reprint The binding site in {beta}2-glycoprotein I for ApoER2' on platelets is located in domain V
    Menno van Lummel
    Department of Haematology and Rheumatology, University Medical Center, 3508GA Utrecht, The Netherlands
    J Biol Chem 280:36729-36. 2005

Collaborators

Detail Information

Publications58

  1. doi request reprint A heparin-bonded vascular graft generates no systemic effect on markers of hemostasis activation or detectable heparin-induced thrombocytopenia-associated antibodies in humans
    Jan M M Heyligers
    Department of Vascular Surgery, University Medical Center Utrecht, Utrecht, The Netherlands
    J Vasc Surg 47:324-9; discussion 329. 2008
    ....
  2. doi request reprint The significance of autoantibodies against β2-glycoprotein I
    Philip G de Groot
    Department of Clinical Chemistry and Haematology, University Medical Center, Heidelberglaan 100, Utrecht, The Netherlands
    Blood 120:266-74. 2012
    ..In this overview, we will summarize our knowledge on the etiology of the autoantibodies, and we will discuss the evidence that identify autoantibodies against β(2)-glycoprotein I as the culprit of APS...
  3. doi request reprint Pathophysiology of thrombotic APS: where do we stand?
    P G de Groot
    Department of Clinical Chemistry and Haematology, University Medical Center, Utrecht, The Netherlands
    Lupus 21:704-7. 2012
    ..Animal models in which passive transfer of patient antibodies into mice resulted in an increased thrombotic response have provided novel insights in the importance of this protein in the pathology of APS...
  4. doi request reprint The future of antiphospholipid antibody testing
    Philip G de Groot
    Department of Clinical Chemistry and Haematology, University Medical Center, Heidelberglaan 100, Utrecht, The Netherlands
    Semin Thromb Hemost 38:412-20. 2012
    ..Based on the progress we have made in our understanding of the physiology of β2GPI, it should be possible to design assays that can better predict the consequences of the presence of aPL in the circulation...
  5. doi request reprint Recent developments in our understanding of the antiphospholipid syndrome
    P G de Groot
    Department of Clinical Chemistry and Haematology, University Medical Center, Utrecht, The Netherlands
    Int J Lab Hematol 34:223-31. 2012
    ..Recent studies on the structure and function of β(2) -glycoprotein I have provided novel insights into the importance of this protein in physiology and its role in the pathology of the antiphospholipid syndrome...
  6. doi request reprint The role of LRP8 (ApoER2') in the pathophysiology of the antiphospholipid syndrome
    P G de Groot
    Department of Clinical Chemistry and Haematology, University Medical Center, Utrecht, The Netherlands
    Lupus 19:389-93. 2010
    ....
  7. doi request reprint Mechanisms of anti-phospholipid antibody formation and action
    Philip G de Groot
    University Medical Centre, Department of Clinical Chemistry and Haematology, Utrecht, The Netherlands
    Thromb Res 127:S40-2. 2011
    ....
  8. doi request reprint β(2) -Glycoprotein I: evolution, structure and function
    P G de Groot
    Department of Clinical Chemistry and Hematology, University Medical Center, Utrecht, The Netherlands
    J Thromb Haemost 9:1275-84. 2011
    ..In this review, we will highlight and summarize the current knowledge on this protein...
  9. doi request reprint Twenty-two years of failure to set up undisputed assays to detect patients with the antiphospholipid syndrome
    Philip G de Groot
    Department of Clinical Chemistry and Haematology, University Medical Centre, Utrecht, Germany
    Semin Thromb Hemost 34:347-55. 2008
    ....
  10. ncbi request reprint The binding site in {beta}2-glycoprotein I for ApoER2' on platelets is located in domain V
    Menno van Lummel
    Department of Haematology and Rheumatology, University Medical Center, 3508GA Utrecht, The Netherlands
    J Biol Chem 280:36729-36. 2005
    ..The binding site in beta(2)GPI for interaction with apoER2' does not overlap with the hydrophobic insertion loop in domain V...
  11. doi request reprint The glycoprotein Ib-IX-V complex contributes to tissue factor-independent thrombin generation by recombinant factor VIIa on the activated platelet surface
    Cees Weeterings
    Department of Clinical Chemistry and Haematology, University Medical Center Utrecht, Utrecht, The Netherlands
    Blood 112:3227-33. 2008
    ..The rFVIIa-GPIbalpha interaction could contribute to cessation of bleeding after administration of rFVIIa to patients with bleeding disorders...
  12. ncbi request reprint Recombinant factor VIIa restores aggregation of alphaIIbbeta3-deficient platelets via tissue factor-independent fibrin generation
    Ton Lisman
    Thrombosis and Hemostasis Laboratory, Department of Hematology, University Medical Centre, Utrecht, The Netherlands
    Blood 103:1720-7. 2004
    ..In conclusion, the efficacy of rFVIIa in GT patients might be explained by induction of alphaIIbbeta3-independent platelet aggregation, which compensates the lack of alphaIIbbeta3-dependent aggregation...
  13. doi request reprint Antiphospholipid antibodies and risk of myocardial infarction and ischaemic stroke in young women in the RATIO study: a case-control study
    Rolf T Urbanus
    Department of Clinical Chemistry and Haematology, University Medical Centre Utrecht, Utrecht, Netherlands
    Lancet Neurol 8:998-1005. 2009
    ....
  14. ncbi request reprint beta2-Glycoprotein I inhibits von Willebrand factor dependent platelet adhesion and aggregation
    Janine J J Hulstein
    Laboratory for Thrombosis and Haemostasis, Department of Clinical Chemistry and Haematology, University Medical Centre Utrecht, Utrecht, The Netherlands
    Blood 110:1483-91. 2007
    ..This mode of action could contribute to the thrombosis and consumptive thrombocytopenia observed in patients with anti-beta(2) GPI antibodies...
  15. pmc Activated factor V is a cofactor for the activation of factor XI by thrombin in plasma
    Coen Maas
    Department of Clinical Chemistry and Haematology, University Medical Center Utrecht, Heidelberglaan 100, 3584 CX Utrecht, The Netherlands
    Proc Natl Acad Sci U S A 107:9083-7. 2010
    ..In conclusion, we propose a role for (activated) factor V as a cofactor in the activation of factor XI by thrombin. These findings offer insights into the coagulation system in both health and disease...
  16. doi request reprint Venous thrombosis risk associated with plasma hypofibrinolysis is explained by elevated plasma levels of TAFI and PAI-1
    Mirjam E Meltzer
    Department of Clinical Chemistry and Hematology, University Medical Center Utrecht, Utrecht, The Netherlands
    Blood 116:113-21. 2010
    ..In conclusion, CLT reflects levels of all fibrinolytic factors except t-PA. Plasminogen, TAFI, PAI-1, and t-PA are associated with venous thrombosis. However, plasminogen and t-PA levels may reflect underlying risk factors...
  17. doi request reprint Plasma levels of fibrinolytic proteins and the risk of myocardial infarction in men
    Mirjam E Meltzer
    Department of Clinical Chemistry and Hematology, University Medical Center Utrecht, Utrecht, The Netherlands
    Blood 116:529-36. 2010
    ..Concluding, elevated alpha2-antiplasmin levels are independently associated with risk of myocardial infarction. t-PA, PAI-1, and plasminogen levels appear to reflect other cardiovascular risk factors...
  18. pmc Synergistic effects of hypofibrinolysis and genetic and acquired risk factors on the risk of a first venous thrombosis
    Mirjam E Meltzer
    Department of Clinical Chemistry and Hematology, University Medical Center Utrecht, Utrecht, The Netherlands
    PLoS Med 5:e97. 2008
    ..Here, we investigated the combined effect of hypofibrinolysis with established risk factors associated with hypercoagulability...
  19. ncbi request reprint Fibrin-incorporated vitronectin is involved in platelet adhesion and thrombus formation through homotypic interactions with platelet-associated vitronectin
    Ya Ping Wu
    Department of Nephrology C3P25, University Medical Centre, Albinusdreef 2, 2333 ZA Leiden, The Netherlands
    Blood 104:1034-41. 2004
    ..This report demonstrates for the first time that self-assembly of VN may provide a physiologically relevant contribution to platelet aggregation on a blood clot...
  20. doi request reprint Targeted phosphotyrosine profiling of glycoprotein VI signaling implicates oligophrenin-1 in platelet filopodia formation
    Onno B Bleijerveld
    Biomolecular Mass Spectrometry and Proteomics and Bijvoet Center for Biomolecular Research and Utrecht Institute for Pharmaceutical Sciences, Utrecht University, Utrecht, The Netherlands
    Arterioscler Thromb Vasc Biol 33:1538-43. 2013
    ..Here, we explore phosphotyrosine signaling events downstream of GPVI with site-specific detail...
  21. doi request reprint The impact of the fibrinolytic system on the risk of venous and arterial thrombosis
    Mirjam E Meltzer
    Department of Clinical Chemistry and Hematology, University Medical Center Utrecht, Utrecht, The Netherlands
    Semin Thromb Hemost 35:468-77. 2009
    ..These properties may be more relevant in arterial than in venous thrombosis...
  22. doi request reprint Immune responses against domain I of β(2)-glycoprotein I are driven by conformational changes: domain I of β(2)-glycoprotein I harbors a cryptic immunogenic epitope
    Bas de Laat
    Department of Clinical Chemistry and Hematology, University Medical Center Utrecht, Utrecht, The Netherlands
    Arthritis Rheum 63:3960-8. 2011
    ..We hypothesized that a conformational change could be a trigger for the formation of antibodies against domain I of β(2)GPI. Therefore, we investigated whether immune responses against β(2)GPI are related to its conformation...
  23. doi request reprint Tissue factor-independent effects of recombinant factor VIIa on hemostasis
    Cees Weeterings
    Department of Clinical Chemistry and Hematology, University Medical Center, Utrecht, The Netherlands
    Semin Hematol 45:S12-5. 2008
    ....
  24. ncbi request reprint Variations in glycosylation of von Willebrand factor with O-linked sialylated T antigen are associated with its plasma levels
    Carina J M van Schooten
    Laboratory for Thrombosis and Haemostasis, Department of Clinical Chemistry and Haematology, University Medical Center Utrecht, Utrecht, The Netherlands
    Blood 109:2430-7. 2007
    ....
  25. pmc Cleavage of von Willebrand factor by granzyme M destroys its factor VIII binding capacity
    Martine J Hollestelle
    Department of Clinical Chemistry and Hematology, University Medical Center Utrecht, Utrecht, The Netherlands
    PLoS ONE 6:e24216. 2011
    ....
  26. pmc Circulating biomarkers for predicting cardiovascular disease risk; a systematic review and comprehensive overview of meta-analyses
    Thijs C van Holten
    Laboratory for Clinical Chemistry and Hematology, UMC Utrecht, Utrecht, The Netherlands
    PLoS ONE 8:e62080. 2013
    ..We performed a systematic review of meta-analyses on levels of serological biomarkers for atherothrombosis to compare the relevance of the most commonly studied biomarkers...
  27. pmc Misfolded proteins activate factor XII in humans, leading to kallikrein formation without initiating coagulation
    Coen Maas
    Department of Clinical Chemistry and Haematology, University Medical Center Utrecht, Utrecht, The Netherlands
    J Clin Invest 118:3208-18. 2008
    ..These results show that the kallikrein-kinin system can be activated by Factor XII, in a process separate from the coagulation cascade, and point to a protective role for Factor XII following activation by misfolded protein aggregates...
  28. ncbi request reprint The presence of active von Willebrand factor under various pathological conditions
    Evelyn Groot
    Laboratory for Thrombosis and Haemostasis, Department of Clinical Chemistry and Haematology, University Medical Center Utrecht, The Netherlands
    Curr Opin Hematol 14:284-9. 2007
    ..To highlight mechanisms that regulate the balance between latent and active von Willebrand factor (VWF), and describe pathological conditions leading to increased levels of active VWF...
  29. ncbi request reprint Dimers of beta 2-glycoprotein I increase platelet deposition to collagen via interaction with phospholipids and the apolipoprotein E receptor 2'
    Bianca C H Lutters
    Department of Haematology, University Medical Center, and Institute of Biomembranes, Utrecht University, 3508GA Utrecht, The Netherlands
    J Biol Chem 278:33831-8. 2003
    ..These results demonstrate that dimeric beta 2GPI induces increased platelet adhesion and thrombus formation, which depends on activation via apoER2'...
  30. ncbi request reprint An experimental model to study the in vivo survival of von Willebrand factor. Basic aspects and application to the R1205H mutation
    Peter J Lenting
    Laboratory for Thrombosis and Haemostasis, Department of Haematology G 03 647, University Medical Center Utrecht, Heidelberglaan 100, 3465 CX Utrecht, The Netherlands
    J Biol Chem 279:12102-9. 2004
    ....
  31. ncbi request reprint Fibrinolysis and the risk of venous and arterial thrombosis
    Mirjam E Meltzer
    Department of Clinical Chemistry and Hematology, University Medical Center Utrecht, Utrecht, The Netherlands
    Curr Opin Hematol 14:242-8. 2007
    ..In this review, we evaluated studies that investigated the association between fibrinolysis and thrombosis...
  32. doi request reprint Reduced plasma fibrinolytic capacity as a potential risk factor for a first myocardial infarction in young men
    Mirjam E Meltzer
    Department of Clinical Chemistry and Haematology, University Medical Centre, Utrecht, The Netherlands
    Br J Haematol 145:121-7. 2009
    ..Our study suggests that hypofibrinolysis increases the risk of a first myocardial infarction in young men, although the causality of this association remains to be determined...
  33. ncbi request reprint Heparin immobilization reduces thrombogenicity of small-caliber expanded polytetrafluoroethylene grafts
    Jan M M Heyligers
    Department of Vascular Surgery, University Medical Center, Utrecht, The Netherlands
    J Vasc Surg 43:587-91. 2006
    ..This study was performed to evaluate the thrombogenicity of heparin-bonded ePTFE grafts compared with standard ePTFE in a newly developed human ex vivo model...
  34. ncbi request reprint Antiphospholipid antibodies: update on detection, pathophysiology, and treatment
    Philip G de Groot
    Departments of Haematology and Rheumatology and Clinical Immunology, University Medical Centre, Heidelberglaan 100, 3584 CX Utrecht, The Netherlands
    Curr Opin Hematol 11:165-9. 2004
    ..It is not possible to identify patients with the syndrome for certain. This paper reviews the substantial and promising headway made in the past year...
  35. doi request reprint Indications for a protective function of beta2-glycoprotein I in thrombotic thrombocytopenic purpura
    Vivian X Du
    Clinical Chemistry and Haematology, University Medical Centre, Utrecht, The Netherlands
    Br J Haematol 159:94-103. 2012
    ..Our findings suggest that β(2) GPI may protect from the effects of hyper-functional VWF by inhibiting its interaction with platelets...
  36. ncbi request reprint Elevated levels of von Willebrand Factor in cirrhosis support platelet adhesion despite reduced functional capacity
    Ton Lisman
    Thrombosis and Haemostasis Laboratory, Department of Haematology, University Medical Centre, Utrecht, The Netherlands
    Hepatology 44:53-61. 2006
    ..This phenomenon might compensate for defects in platelet number and function in patients with cirrhosis...
  37. ncbi request reprint Beta2-glycoprotein I and LDL-receptor family members
    Philip G de Groot
    Department of Haematology and Rheumatology and Clinical Immunology, University Medical Center, Heidelberglaan 100, 3584CX Utrecht, The Netherlands
    Thromb Res 114:455-9. 2004
    ..In combination with new information on the complex interaction between antiphospholipid antibodies, the protein beta2-Glycoprotein I, and cellular surfaces have opened new avenues for the understanding of the pathology of this syndrome...
  38. doi request reprint A fibronectin-fibrinogen-tropoelastin coating reduces smooth muscle cell growth but improves endothelial cell function
    Claudia Tersteeg
    Department of Experimental Cardiology, UMC Utrecht, Utrecht, The Netherlands
    J Cell Mol Med 16:2117-26. 2012
    ..These data suggest that coating a mixture of fibronectin/fibrinogen/tropoelastin on a stent may promote reendothelialization, while keeping unfavourable processes such as restenosis and procoagulant activity limited...
  39. doi request reprint F8 gene mutation type and inhibitor development in patients with severe hemophilia A: systematic review and meta-analysis
    Samantha C Gouw
    Department of Pediatrics, Wilhelmina Children s Hospital, University Medical Center Utrecht, Utrecht, The Netherlands
    Blood 119:2922-34. 2012
    ..6-1.5), and the risk in small deletions/insertions and missense mutations was lower (pooled OR = 0.5; 95% CI, 0.4-0.6 and OR = 0.3; 95% CI, 0.2-0.4, respectively). The relative risks for developing high titer inhibitors were similar...
  40. ncbi request reprint Current insight into diagnostics and pathophysiology of the antiphospolipid syndrome
    Rolf T Urbanus
    Department of Clinical Chemistry and Haematology, University Medical Centre Utrecht, Heidelberglaan 100, 3584CX Utrecht, The Netherlands
    Blood Rev 22:93-105. 2008
    ..In vivo data should provide more insight into the importance of the interaction with individual receptors...
  41. pmc Up-regulation of platelet activation in hemophilia A
    Esther R van Bladel
    Department of Clinical Chemistry and Hematology Van Creveldlaboratory, University Medical Center Utrecht, Heidelberglaan 100 G03 550, 3584 CX Utrecht, The Netherlands
    Haematologica 96:888-95. 2011
    ....
  42. doi request reprint New insights into the role of erythrocytes in thrombus formation
    Vivian X Du
    Department of Clinical Chemistry and Hematology, University Medical Center Utrecht, Utrecht, The Netherlands
    Semin Thromb Hemost 40:72-80. 2014
    ..This review will provide more in-detail information of existing and new hypotheses regarding the role of erythrocytes in thrombus formation. ..
  43. pmc Autoantibodies directed against domain I of beta2-glycoprotein I
    Bas de Laat
    Department of Clinical Chemistry and Hematology, University Medical Center Utrecht, 3584CX Utrecht, The Netherlands
    Curr Rheumatol Rep 13:70-6. 2011
    ..This review discusses several studies that have investigated a role for domain I within the antiphospholipid syndrome on a predominantly diagnostic level...
  44. ncbi request reprint Elevated levels of D-dimer and fragment 1+2 upon central venous catheter insertion and factor V Leiden predict subclavian vein thrombosis
    Flip H Jansen
    Department of Haematology, University Medical Center Utrecht, Heidelberglaan 100, 3584 CX Utrecht, The Netherlands
    Haematologica 90:499-504. 2005
    ..We studied whether the determination of D-dimer levels, fragment 1+2 levels and factor V Leiden can identify patients at high risk of developing subclavian vein thrombosis...
  45. ncbi request reprint Tests for lupus anticoagulant revisited
    Ronald H W M Derksen
    Department of Rheumatology and Clinical Immunology F02 127, University Medical Center Utrecht, Heidelberglaan 100, 3584 GA Utrecht, The Netherlands
    Thromb Res 114:521-6. 2004
  46. doi request reprint Antiphospholipid antibodies--we are not quite there yet
    Rolf T Urbanus
    Department of Clinical Chemistry and Haematology, University Medical Center Utrecht, Utrecht, The Netherlands
    Blood Rev 25:97-106. 2011
    ..We are in need of better assays to detect those individuals at risk for thrombosis and population-based prospective studies to provide us with accurate risk assessments...
  47. ncbi request reprint beta 2 Glycoprotein I--a key player in the antiphospholipid syndrome
    Bianca C H Lutters
    Department of Haematology, University Medical Center, Utrecht, The Netherlands
    Isr Med Assoc J 4:958-62. 2002
  48. ncbi request reprint Reduced plasma fibrinolytic potential is a risk factor for venous thrombosis
    Ton Lisman
    Thrombosis and Haemostasis Laboratory, Department of Haematology G 03 647, University Medical Centre, Heidelberglaan 100, 3584 CX Utrecht, The Netherlands
    Blood 105:1102-5. 2005
    ..6 for 90th percentile). Taken together, these results indicate that plasma hypofibrinolysis constitutes a risk factor for venous thrombosis, with a doubling of the risk at clot lysis times that are present in 10% of the population...
  49. doi request reprint Chronic dysfunction of the endothelium is associated with mortality in acute coronary syndrome patients
    Agon Hyseni
    Department of Clinical Chemistry and Haematology, University Medical Center Utrecht, The Netherlands
    Thromb Res 131:198-203. 2013
    ..The aim of this study was to investigate the relationship between platelet and endothelial cell activation markers and mortality in patients presenting with ACS...
  50. doi request reprint From antibody to clinical phenotype, the black box of the antiphospholipid syndrome: pathogenic mechanisms of the antiphospholipid syndrome
    Vivian X Du
    Clinical Chemistry and Hematology, University Medical Center Utrecht, Utrecht, The Netherlands Sanquin Research, Sanquin Blood Supply Foundation, Amsterdam, The Netherlands
    Thromb Res 132:319-26. 2013
    ....
  51. pmc Platelet activation determines angiopoietin-1 and VEGF levels in malaria: implications for their use as biomarkers
    Judith Brouwers
    Department of Clinical Chemistry and Haematology, University Medical Centre, Utrecht, The Netherlands
    PLoS ONE 8:e64850. 2013
    ....
  52. ncbi request reprint Glycation induces formation of amyloid cross-beta structure in albumin
    Barend Bouma
    Department of Medical Oncology, University Medical Center Utrecht, Heidelberglaan 100, 3584 CX Utrecht, The Netherlands
    J Biol Chem 278:41810-9. 2003
    ..This would explain how glycated ligands and amyloid ligands can bind to the same multiligand "cross-beta structure" receptors and to tPA...
  53. ncbi request reprint Enhancement of fibrinolytic potential in vitro by anticoagulant drugs targeting activated factor X, but not by those inhibiting thrombin or tissue factor
    Ton Lisman
    Thrombosis and Haemostasis Laboratory, Department of Haematology, University Medical Centre, Utrecht, The Netherlands
    Blood Coagul Fibrinolysis 14:557-62. 2003
    ..On the other hand, the induction of hyperfibrinolysis by these compounds might increase the risk of bleeding complications...
  54. ncbi request reprint The role of von Willebrand factor in platelet function
    Philip G de Groot
    University Medical Center, Utrecht, The Netherlands
    Semin Thromb Hemost 28:133-8. 2002
    ..After a first layer of platelets has been formed, vWF is also crucial as a link between platelets in the forming thrombus. In this article, the current knowledge on the role of vWF in primary hemostasis is reviewed...
  55. ncbi request reprint Recombinant factor VIIa improves clot formation but not fibrolytic potential in patients with cirrhosis and during liver transplantation
    Ton Lisman
    Thrombosis and Haemostasis Laboratory, Department of Haematology G 03 647, University Medical Center, P O Box 85500, 3508 GA Utrecht, The Netherlands
    Hepatology 35:616-21. 2002
    ..In conclusion, this study shows no evidence for an antifibrinolytic effect of rFVIIa in cirrhotic patients or in patients undergoing OLT...
  56. ncbi request reprint Thrombopoietin increases platelet adhesion under flow and decreases rolling
    Erim Van Os
    Thrombosis and Haemostasis Laboratory, Department of Haematology, University Medical Centre Utrecht, Utrecht, The Netherlands
    Br J Haematol 121:482-90. 2003
    ..Thus, TPO potentiates the direct and firm attachment of platelets to surface-coated ligands for alphaIIbbeta3, possibly by increasing the ligand affinity of the integrin...
  57. ncbi request reprint Recombinant factor VIIa enhances deposition of platelets with congenital or acquired alpha IIb beta 3 deficiency to endothelial cell matrix and collagen under conditions of flow via tissue factor-independent thrombin generation
    Ton Lisman
    Thrombosis and Haemostasis Laboratory, Department of Haematology, University Medical Centre, Utrecht, The Netherlands
    Blood 101:1864-70. 2003
    ..The enhanced generation of platelet procoagulant surface facilitates fibrin formation, so that lack of platelet aggregate formation might be compensated for...
  58. ncbi request reprint Haemostatic abnormalities in patients with liver disease
    Ton Lisman
    Thrombosis and Haemostasis Laboratory, Department of Haematology G 03 647, University Medical Centre, Utrecht, The Netherlands
    J Hepatol 37:280-7. 2002