Paul E de Jong

Summary

Affiliation: University Medical Center Groningen
Country: The Netherlands

Publications

  1. ncbi request reprint Equations used to predict glomerular filtration rate perform poorly in kidney transplant recipients
    Paul E de Jong
    Division of Nephrology, Department of Medicine, University Medical Center, University of Groningen, 9700 RB Groningen, The Netherlands
    Nat Clin Pract Nephrol 2:300-1. 2006
  2. pmc Measurement of coronary calcium scores or exercise testing as initial screening tool in asymptomatic subjects with ST-T changes on the resting ECG: an evaluation study
    Christiane A Geluk
    Department of Cardiology, Thoraxcenter, University Medical Center Groningen, University of Groningen, The Netherlands
    BMC Cardiovasc Disord 7:19. 2007
  3. doi request reprint Focus on microalbuminuria to improve cardiac and renal protection
    Paul E de Jong
    Division of Nephrology, Department of Medicine, University Medical Center Groningen, Groningen, The Netherlands
    Nephron Clin Pract 111:c204-10; discussion c211. 2009
  4. ncbi request reprint Renoprotective therapy: is it blood pressure or albuminuria that matters?
    Paul E de Jong
    Division of Nephrology, Department of Medicine, University Medical Center Groningen, 9713 GZ Groningen, Netherlands
    Lancet 365:913-4. 2005
  5. ncbi request reprint Macroalbuminuria and microalbuminuria: do both predict renal and cardiovascular events with similar strength?
    Paul E de Jong
    Department of Medicine, University Medical Centre Groningen, University of Groningen, Groningen, The Netherlands
    J Nephrol 20:375-80. 2007
  6. ncbi request reprint Prevention of chronic kidney disease: the next step forward!
    Paul E de Jong
    Division of Nephrology, Department of Medicine, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    Nephrology (Carlton) 11:240-4. 2006
  7. ncbi request reprint Proteinuria lowering needs a multifactorial and individualized approach to halt progression of renal disease
    Paul E de Jong
    Division of Nephrology, University Medical Center Groningen, Groningen, The Netherlands
    Nat Clin Pract Nephrol 4:654-5. 2008
  8. doi request reprint Screening for chronic kidney disease: where does Europe go?
    Paul E de Jong
    Department of Medicine, Division of Nephrology, University Medical Center Groningen, Hanzeplein 1, 9713 EZ Groningen, Netherlands
    Clin J Am Soc Nephrol 3:616-23. 2008
  9. ncbi request reprint Screening, monitoring, and treatment of albuminuria: Public health perspectives
    Paul E de Jong
    Division of Nephrology, Department of Medicine, University Medical Center Groningen, Groningen University, Hanzeplein 1, 9713 GZ Groningen, The Netherlands
    J Am Soc Nephrol 17:2120-6. 2006
  10. ncbi request reprint Screening techniques for detecting chronic kidney disease
    Paul E de Jong
    Division of Nephrology, Department of Medicine, University Medical Center Groningen, University of Groningen, The Netherlands
    Curr Opin Nephrol Hypertens 14:567-72. 2005

Detail Information

Publications103 found, 100 shown here

  1. ncbi request reprint Equations used to predict glomerular filtration rate perform poorly in kidney transplant recipients
    Paul E de Jong
    Division of Nephrology, Department of Medicine, University Medical Center, University of Groningen, 9700 RB Groningen, The Netherlands
    Nat Clin Pract Nephrol 2:300-1. 2006
  2. pmc Measurement of coronary calcium scores or exercise testing as initial screening tool in asymptomatic subjects with ST-T changes on the resting ECG: an evaluation study
    Christiane A Geluk
    Department of Cardiology, Thoraxcenter, University Medical Center Groningen, University of Groningen, The Netherlands
    BMC Cardiovasc Disord 7:19. 2007
    ..However, it is not clear which test should be preferred as initial diagnostic test. We evaluated the prevalence of documented coronary artery disease (CAD) according to calcium scores and exercise test results...
  3. doi request reprint Focus on microalbuminuria to improve cardiac and renal protection
    Paul E de Jong
    Division of Nephrology, Department of Medicine, University Medical Center Groningen, Groningen, The Netherlands
    Nephron Clin Pract 111:c204-10; discussion c211. 2009
    ..In this review, we will show evidence that screening for albuminuria may be of great benefit, not only as an argument to start treatment to prevent progressive renal function loss, but also to prevent cardiovascular events...
  4. ncbi request reprint Renoprotective therapy: is it blood pressure or albuminuria that matters?
    Paul E de Jong
    Division of Nephrology, Department of Medicine, University Medical Center Groningen, 9713 GZ Groningen, Netherlands
    Lancet 365:913-4. 2005
  5. ncbi request reprint Macroalbuminuria and microalbuminuria: do both predict renal and cardiovascular events with similar strength?
    Paul E de Jong
    Department of Medicine, University Medical Centre Groningen, University of Groningen, Groningen, The Netherlands
    J Nephrol 20:375-80. 2007
    ..When promoting routine screening for albuminuria, one should realize, moreover, that such projects will most likely be much more cost-effective when directed to preventing not only renal end points, but also CV end points...
  6. ncbi request reprint Prevention of chronic kidney disease: the next step forward!
    Paul E de Jong
    Division of Nephrology, Department of Medicine, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    Nephrology (Carlton) 11:240-4. 2006
    ..Because microalbuminuria not only indicates increased renal but also enhanced cardiovascular risk, the benefits of such screening programmes may have a much greater affect than only preventing renal disease...
  7. ncbi request reprint Proteinuria lowering needs a multifactorial and individualized approach to halt progression of renal disease
    Paul E de Jong
    Division of Nephrology, University Medical Center Groningen, Groningen, The Netherlands
    Nat Clin Pract Nephrol 4:654-5. 2008
    ..The data do, however, encourage an individualized and more active approach to preventing end-stage renal disease in individuals with proteinuric chronic kidney disease...
  8. doi request reprint Screening for chronic kidney disease: where does Europe go?
    Paul E de Jong
    Department of Medicine, Division of Nephrology, University Medical Center Groningen, Hanzeplein 1, 9713 EZ Groningen, Netherlands
    Clin J Am Soc Nephrol 3:616-23. 2008
    ....
  9. ncbi request reprint Screening, monitoring, and treatment of albuminuria: Public health perspectives
    Paul E de Jong
    Division of Nephrology, Department of Medicine, University Medical Center Groningen, Groningen University, Hanzeplein 1, 9713 GZ Groningen, The Netherlands
    J Am Soc Nephrol 17:2120-6. 2006
    ....
  10. ncbi request reprint Screening techniques for detecting chronic kidney disease
    Paul E de Jong
    Division of Nephrology, Department of Medicine, University Medical Center Groningen, University of Groningen, The Netherlands
    Curr Opin Nephrol Hypertens 14:567-72. 2005
    ....
  11. ncbi request reprint [Population screening for urinary protein loss: a sensible action]
    P E de Jong
    Universitair Medisch Centrum Groningen, afd Nefrologie, Postbus 30 001, 9700 RB Groningen
    Ned Tijdschr Geneeskd 151:1055-8. 2007
    ..In both conditions, treatment with RAAS blockade is indicated and is aimed at both cardiac and renal protection. There are arguments indicating that screening of the general population for urinary protein loss is cost-effective...
  12. ncbi request reprint Risk factors for chronic transplant dysfunction and cardiovascular disease are related to accumulation of advanced glycation end-products in renal transplant recipients
    Jasper W L Hartog
    University Medical Center Groningen, University of Groningen, Department of Medicine, Division of Nephrology, PO Box 30 001, 9700 RB Groningen, The Netherlands
    Nephrol Dial Transplant 21:2263-9. 2006
    ..We aimed to investigate which factors are associated with tissue AGE accumulation in renal transplant recipients...
  13. pmc Copeptin, a surrogate marker of vasopressin, is associated with disease severity in autosomal dominant polycystic kidney disease
    Esther Meijer
    Division of Nephrology, Department of Internal Medicine, University Medical Center Groningen, PO Box 30 001, 9700 RB Groningen, The Netherlands
    Clin J Am Soc Nephrol 6:361-8. 2011
    ..However, it is unknown whether endogenous vasopressin concentration is associated with disease severity in patients with ADPKD...
  14. doi request reprint Lower estimated glomerular filtration rate and higher albuminuria are associated with all-cause and cardiovascular mortality. A collaborative meta-analysis of high-risk population cohorts
    Marije van der Velde
    Department of Nephrology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    Kidney Int 79:1341-52. 2011
    ..Thus, lower eGFR and higher albuminuria are risk factors for all-cause and cardiovascular mortality in high-risk populations, independent of each other and of cardiovascular risk factors...
  15. ncbi request reprint Renal function dependent association of AGTR1 polymorphism (A1166C) and electrocardiographic left-ventricular hypertrophy
    Tom D J Smilde
    Thorax Center, Department of Cardiology, University Medical Center Groningen, Groningen, The Netherlands
    Am J Hypertens 20:1097-103. 2007
    ..We studied whether renal function modulates the association between RAS polymorphisms and LVH in a cross-sectional study of 8592 inhabitants of Groningen...
  16. pmc Early renal abnormalities in autosomal dominant polycystic kidney disease
    Esther Meijer
    Division of Nephrology, Department of Medicine, University Medical Center Groningen, Groningen, The Netherlands
    Clin J Am Soc Nephrol 5:1091-8. 2010
    ..A pivotal question will be when to initiate such treatment, and monitoring disease progression will thus become more important. Therefore, the prevalence of renal abnormalities in ADPKD at different ages was evaluated...
  17. doi request reprint Development and validation of a general population renal risk score
    Nynke Halbesma
    Division of Nephrology, Department of Medicine, University Medical Center Groningen, University Hospital Groningen, Groningen, The Netherlands
    Clin J Am Soc Nephrol 6:1731-8. 2011
    ..73 m² during follow-up were defined as having progressive CKD. Possible predictors for progressive CKD were selected on the basis of univariable logistic regression analyses...
  18. doi request reprint N-terminal pro-B-type natriuretic peptide and mortality in renal transplant recipients versus the general population
    Leendert H Oterdoom
    Department of Internal Medicine, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    Transplantation 87:1562-70. 2009
    ..Mortality rates are higher in renal transplant recipients (RTR) than in the general population (GP). It is unknown what risk factors account for this difference...
  19. ncbi request reprint Elevated levels of C-reactive protein independently predict accelerated deterioration of graft function in renal transplant recipients
    Rutger M van Ree
    Department of Medicine, University Medical Center Groningen, PO Box 30 001, 9700 RB Groningen, The Netherlands
    Nephrol Dial Transplant 22:246-53. 2007
    ..In this prospective study, we investigated whether CRP could be of use as a clinical marker for early identification of renal transplant recipients at increased risk of deterioration of graft function...
  20. doi request reprint Gender differences in predictors of the decline of renal function in the general population
    Nynke Halbesma
    Division of Nephrology, Department of Medicine, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    Kidney Int 74:505-12. 2008
    ..These studies show that there are gender differences in the standard predictors of the decline in renal function...
  21. doi request reprint Exploration of the difference in incidence of renal replacement therapy between Flanders and the Netherlands--investigation of explanatory variables
    Annemieke Visser
    Department of Health Sciences, Graduate School for Health Research, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    Nephrol Dial Transplant 27:803-9. 2012
    ..This study investigates the difference in the incidence of renal replacement therapy (RRT) between Flanders and the Netherlands and possible explanations for this difference...
  22. doi request reprint Urinary creatinine excretion reflecting muscle mass is a predictor of mortality and graft loss in renal transplant recipients
    Leendert H Oterdoom
    Department of Medicine, University Medical Center Groningen, Groningen, The Netherlands
    Transplantation 86:391-8. 2008
    ..Skeletal muscle mainly determines peripheral insulin resistance, and could therefore affect outcome...
  23. ncbi request reprint Cost-effectiveness of screening for albuminuria with subsequent fosinopril treatment to prevent cardiovascular events: A pharmacoeconomic analysis linked to the prevention of renal and vascular endstage disease (PREVEND) study and the prevention of renal
    Jarir Atthobari
    Department of Social Pharmacy, Pharmacoepidemiology and Pharmacotherapy, Groningen UniversityInstitute for Drug Exploration, Groningen, The Netherlands
    Clin Ther 28:432-44. 2006
    ....
  24. pmc Impact of the preintervention rate of renal function decline on outcome of renoprotective intervention
    A Titia Lely
    Department of Internal Medicine, Division of Nephrology, University Medical Center Groningen, University of Groningen, Hanzeplein 1, 9713 GZ Groningen, Netherlands
    Clin J Am Soc Nephrol 3:54-60. 2008
    ..There are no data showing that this provides groups with similar baseline rates of renal function loss. Accordingly, the impact of preintervention rate of renal function loss (slope) on outcome of studies has not been established...
  25. ncbi request reprint An increased coronary risk is paradoxically associated with common cholesteryl ester transfer protein gene variations that relate to higher high-density lipoprotein cholesterol: a population-based study
    Susanna E Borggreve
    Department of Endocrinology, University Medical Center Groningen and University of Groningen, Hanzeplein 1, P O Box 30 001, 9700 RB Groningen, The Netherlands
    J Clin Endocrinol Metab 91:3382-8. 2006
    ....
  26. ncbi request reprint Involvement of renal ACE activity in proteinuria-associated renal damage in untreated and treated adriamycin nephrotic rats
    Hendrik Bos
    Department of Nephrology, Groningen University, Groningen, The Netherlands
    J Renin Angiotensin Aldosterone Syst 4:106-12. 2003
    ..Renal ACE activity is a consistent marker of individual differences in proteinuria-associated renal damage: further studies are needed to investigate a possible pathogenetic role in renal damage...
  27. ncbi request reprint C-reactive protein modifies the relationship between blood pressure and microalbuminuria
    Erik M Stuveling
    Department of Medicine, University Medical Center, Groningen, The Netherlands
    Hypertension 43:791-6. 2004
    ..0004). No significant interactions between other risk factors and CRP with respect to the risk of microalbuminuria were encountered. Thus, CRP modifies the relation between blood pressure and microalbuminuria...
  28. ncbi request reprint Validation of insulin resistance indexes in a stable renal transplant population
    Leendert H Oterdoom
    Renal Transplant Program, University of Groningen and University Medical Center Groningen, P O Box 30 001, 9700 RB Groningen, Netherlands
    Diabetes Care 28:2424-9. 2005
    ..The purpose of this study was to investigate the validity of established insulin resistance indexes, based on fasting blood parameters, in a stable renal transplant population...
  29. ncbi request reprint Abdominal obesity and smoking are important determinants of C-reactive protein in renal transplant recipients
    Rutger M van Ree
    Renal Transplant Program, University Medical Center Groningen, Groningen, The Netherlands
    Nephrol Dial Transplant 20:2524-31. 2005
    ..However, it may also reflect a low-grade immune-mediated response to the graft. In this study we investigated the factors associated with CRP in a renal transplant population...
  30. doi request reprint External validation of the KORA S4/F4 prediction models for the risk of developing type 2 diabetes in older adults: the PREVEND study
    Ali Abbasi
    Department of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands
    Eur J Epidemiol 27:47-52. 2012
    ..However, the models need to be corrected for intercept and slope to acquire good calibration for application in a different setting...
  31. doi request reprint Urinary creatinine excretion, an indirect measure of muscle mass, is an independent predictor of cardiovascular disease and mortality in the general population
    Leendert H Oterdoom
    Department of Internal Medicine, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    Atherosclerosis 207:534-40. 2009
    ..We aimed to determine whether muscle mass, as reflected by 24h urinary creatinine excretion, is associated with CVD and whether this depends on insulin resistance...
  32. ncbi request reprint The association between atherosclerotic risk factors and renal function in the general population
    Jacobien C Verhave
    Department of Medicine, Division of Nephrology, Groningen University Medical Center, Groningen, The Netherlands
    Kidney Int 67:1967-73. 2005
    ..Generalized atherosclerosis is increasingly recognized as an important cause of end-stage renal disease (ESRD). We questioned to what extent atherosclerotic risk factors determine renal function in the general population...
  33. doi request reprint Vasopressin, copeptin, and renal concentrating capacity in patients with autosomal dominant polycystic kidney disease without renal impairment
    Debbie Zittema
    Department of Nephrology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    Clin J Am Soc Nephrol 7:906-13. 2012
    ..It is clinically acknowledged that ADPKD patients have impaired urine concentrating capacity, but the mechanism behind this observation is unknown...
  34. ncbi request reprint The effect of statins on urinary albumin excretion and glomerular filtration rate: results from both a randomized clinical trial and an observational cohort study
    Jarir Atthobari
    Department of Social Pharmacy, Pharmacoepidemiology and Pharmacotherapy, Groningen University for Drug Exploration GUIDE, Antonius Deusinglaan 1, 9713 AV, Groningen, The Netherlands
    Nephrol Dial Transplant 21:3106-14. 2006
    ....
  35. ncbi request reprint Relation of electrocardiographic abnormalities to levels of serum C-reactive protein
    Folkert W Asselbergs
    Department of Clinical Pharmacology, University of Groningen, Antonius Deusinglaan 1, 9713 AV Groningen, The Netherlands
    Am J Cardiol 91:1358-60. 2003
  36. doi request reprint Albuminuria, proteinuria, and novel urine biomarkers as predictors of long-term allograft outcomes in kidney transplant recipients
    Ferdau L Nauta
    Department of Internal Medicine, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    Am J Kidney Dis 57:733-43. 2011
    ....
  37. doi request reprint Copeptin, a surrogate marker of vasopressin, is associated with microalbuminuria in a large population cohort
    Esther Meijer
    Department of Internal Medicine, Division of Nephrology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    Kidney Int 77:29-36. 2010
    ..If future studies show that this association is causal, then drinking more water or pharmacological intervention to decrease plasma vasopressin may have beneficial effects on the kidney, especially in the elderly...
  38. ncbi request reprint Determinants of insulin resistance in renal transplant recipients
    Leendert H Oterdoom
    Renal Transplant Program, University Medical Center Groningen and University of Groningen, Groningen, The Netherlands
    Transplantation 83:29-35. 2007
    ..It is not known to date which factors relate to this excess insulin resistance. Therefore, we investigated which factors are related to insulin resistance long-term after renal transplantation...
  39. ncbi request reprint Mild renal dysfunction is associated with electrocardiographic left ventricular hypertrophy
    Tom D J Smilde
    Department of Cardiology, Thoraxcenter, University Hospital Groningen, Hanzeplein 1, P O Box 30001, 9700 RB Gronigen, The Netherlands
    Am J Hypertens 18:342-7. 2005
    ..We studied the relation between renal dysfunction and LVH in a cross-sectional study in 8592 inhabitants from Groningen, The Netherlands...
  40. ncbi request reprint A central body fat distribution is related to renal function impairment, even in lean subjects
    Sara Joan Pinto-Sietsma
    Division of Nephrology, Department of Internal Medicine, University Hospital Groningen, Groningen, The Netherlands
    Am J Kidney Dis 41:733-41. 2003
    ..Whether this depends on fat distribution is not known. We hypothesize that in addition to overweight, fat distribution may be associated with renal function abnormalities...
  41. ncbi request reprint Social participation after successful kidney transplantation
    Sijrike F van der Mei
    Department of Health Sciences, Northern Centre for Healthcare Research NCH, University Medical Centre Groningen UMCG, University of Groningen, The Netherlands
    Disabil Rehabil 29:473-83. 2007
    ..To explore and describe the degree of social participation after kidney transplantation and to examine associated factors...
  42. ncbi request reprint Long-term effects of pravastatin and fosinopril on peripheral endothelial function in albuminuric subjects
    Folkert W Asselbergs
    Department of Cardiology, University Medical Center Groningen, Groningen, The Netherlands
    Atherosclerosis 196:349-55. 2008
    ..01). In conclusion, after 4 years of follow-up, pravastatin treatment tended to increase FMD and this effect was predominantly present in men. Fosinopril treatment did not modify FMD during long-term follow-up...
  43. doi request reprint Influence of age on the prognostic value of mid-regional pro-adrenomedullin in the general population
    Frank P Brouwers
    Department of Cardiology, University Medical Center Groningen, University of Groningen, The Netherlands
    Heart 98:1348-53. 2012
    ..The aim of this study was to evaluate the prognostic performance of MR-proADM in the general population, controlling for these potential confounders...
  44. doi request reprint Do albuminuria and hs-CRP add to the International Diabetes Federation definition of the metabolic syndrome in predicting outcome?
    Marije van der Velde
    Division of Nephrology, Department of Medicine, University Medical Center Groningen, University Hospital Groningen, Groningen, The Netherlands
    Nephrol Dial Transplant 27:2275-83. 2012
    ....
  45. ncbi request reprint Fasting insulin modifies the relation between age and renal function
    Leendert H Oterdoom
    Department of Medicine, University Medical Center Groningen, Hanzeplein 1, Postbus 30 001, 9700 RB Groningen, The Netherlands
    Nephrol Dial Transplant 22:1587-92. 2007
    ..This population-based study is the first to investigate whether fasting insulin concentrations modify the relationship between age and renal function in a general non-diabetic population...
  46. pmc Influence of age and measure of eGFR on the association between renal function and cardiovascular events
    Marije van der Velde
    Division of Nephrology, Department of Internal Medicine, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    Clin J Am Soc Nephrol 5:2053-9. 2010
    ..This study investigates whether the association between estimated GFR (eGFR) and cardiovascular (CV) outcome differs for different measures of eGFR and different age groups...
  47. ncbi request reprint Effects of relative blood volume-controlled hemodialysis on blood pressure and volume status in hypertensive patients
    Judith J Dasselaar
    Dialysis Centre Groningen, University Medical Centre Groningen, Groningen, The Netherlands
    ASAIO J 53:357-64. 2007
    ..Although the mean weight did not change, the reductions in cardiothoracic ratio and extracellular water suggest that HD with BVT resulted in optimization of volume status...
  48. doi request reprint Lower estimated GFR and higher albuminuria are associated with adverse kidney outcomes. A collaborative meta-analysis of general and high-risk population cohorts
    Ron T Gansevoort
    Department of Nephrology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    Kidney Int 80:93-104. 2011
    ..Thus, lower eGFR and higher albuminuria are risk factors for ESRD, acute kidney injury and progressive CKD in both general and high-risk populations, independent of each other and of cardiovascular risk factors...
  49. ncbi request reprint Impact of statins in microalbuminuric subjects with the metabolic syndrome: a substudy of the PREVEND Intervention Trial
    Christiane A Geluk
    Department of Cardiology, Thoraxcenter, University Medical Center Groningen, University of Groningen, Postbus 30001, Hanzeplein 1, 9700 RB, Groningen, The Netherlands
    Eur Heart J 26:1314-20. 2005
    ..We evaluated the impact of pravastatin treatment on the incidence of major adverse cardiac events in microalbuminuric subjects with the metabolic syndrome...
  50. ncbi request reprint What predicts progression and regression of urinary albumin excretion in the nondiabetic population?
    Auke H Brantsma
    Division of Nephrology, Department of Medicine, University Medical Center Groningen, PO Box 30 001, 9700 RB Groningen, The Netherlands
    J Am Soc Nephrol 18:637-45. 2007
    ....
  51. doi request reprint Screen-and-treat strategies for albuminuria to prevent cardiovascular and renal disease: cost-effectiveness of nationwide and targeted interventions based on analysis of cohort data from the Netherlands
    Cornelis Boersma
    Unit of Pharmacoepidemiology and Pharmacoeconomics, Department of Pharmacy, University of Groningen, Groningen, The Netherlands
    Clin Ther 32:1103-21. 2010
    ..Albuminuria is a marker for renal and cardiovascular (CV) risk, allowing early diagnosis of subjects with elevated renal and CV risk...
  52. ncbi request reprint Effects of fosinopril and pravastatin on cardiovascular events in subjects with microalbuminuria
    Folkert W Asselbergs
    Department of Clinical Pharmacology, University of Groningen, Groningen, The Netherlands
    Circulation 110:2809-16. 2004
    ..We assessed whether therapeutic intervention aimed at lowering urinary albumin excretion would reduce cardiovascular events in microalbuminuric subjects (15 to 300 mg/24 hours)...
  53. doi request reprint Changes in renal risk factors versus renal function outcome during follow-up in a population-based cohort study
    Nynke Halbesma
    Division of Nephrology, Department of Medicine, University Medical Center Groningen UMCG, University of Groningen, Groningen, The Netherlands
    Nephrol Dial Transplant 25:1846-53. 2010
    ..Therefore, the aim of this study was to investigate whether besides the baseline values of these risk factors, changes in risk factors are associated with subsequent rate of renal function loss...
  54. doi request reprint Copeptin, a surrogate marker for vasopressin, is associated with kidney function decline in subjects with autosomal dominant polycystic kidney disease
    Wendy E Boertien
    Department of Nephrology, University Medical Center Groningen, Groningen, The Netherlands
    Nephrol Dial Transplant 27:4131-7. 2012
    ..It is, however, unknown whether endogenous vasopressin concentration is associated with kidney function decline in subjects with ADPKD...
  55. ncbi request reprint Urinary albumin excretion as a predictor of the development of hypertension in the general population
    Auke H Brantsma
    Division of Nephrology, Department of Medicine, University Medical Center Groningen, PO Box 30 001, Groningen, 9700 RB The Netherlands
    J Am Soc Nephrol 17:331-5. 2006
    ..In conclusion, these findings support the hypothesis that mild renal damage may precede the development of hypertension...
  56. ncbi request reprint Urinary albumin excretion and its relation with C-reactive protein and the metabolic syndrome in the prediction of type 2 diabetes
    Auke H Brantsma
    Division of Nephrology, Department of Medicine, University Medical Center Groningen, P O Box 30, 001, 9700 RB, Groningen, Netherlands
    Diabetes Care 28:2525-30. 2005
    ..To investigate urinary albumin excretion (UAE) and its relation with C-reactive protein (CRP) and the metabolic syndrome in the prediction of the development of type 2 diabetes...
  57. pmc Glomerular and tubular damage markers are elevated in patients with diabetes
    Ferdau L Nauta
    Department of Nephrology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    Diabetes Care 34:975-81. 2011
    ....
  58. ncbi request reprint Effects of anti-proteinuric therapy with angiotensin-converting-enzyme inhibition on renal protein catabolism in the adriamycin-induced nephrotic rat
    Marijke Haas
    Department of Clinical Pharmacology, Groningen University Institute for Drug Exploration, University of Groningen, P O Box 196, NL 9700 AD Groningen, The Netherlands
    Clin Sci (Lond) 105:51-7. 2003
    ..Taken together, the data suggest that proteinuria is toxic for the proximal tubular cells and that ACE inhibition protects the remaining functional tubular cells directly against destruction through decreasing hypercatabolism...
  59. ncbi request reprint Accepting or declining dialysis: considerations taken into account by elderly patients with end-stage renal disease
    Annemieke Visser
    Department of Health Sciences, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    J Nephrol 22:794-9. 2009
    ..This study explores the considerations taken into account by these patients in decision-making regarding renal replacement therapy...
  60. pmc Screening for albuminuria identifies individuals at increased renal risk
    Marije van der Velde
    Division of Nephrology, Department of Internal Medicine, University Medical Center Groningen, Groningen, The Netherlands
    J Am Soc Nephrol 20:852-62. 2009
    ..Screening for albuminuria identifies patients at increased risk for progressive renal disease, 40 to 50% of whom were previously undiagnosed or untreated...
  61. ncbi request reprint Comparison of amino acid oxidation and urea metabolism in haemodialysis patients during fasting and meal intake
    Jorden M Veeneman
    Department of Internal Medicine, Division of Nephrology, University Hospital Groningen and Groningen University Institute of Drug Exploration, The Netherlands
    Nephrol Dial Transplant 19:1533-41. 2004
    ..However, urea is hydrolysed in the intestine and the resulting ammonia could be used metabolically. The magnitude and dependence on protein intake of this process are unknown in HD patients...
  62. ncbi request reprint Oxidative metabolism appears to be reduced in long-term hemodialysis patients
    Jorden M Veeneman
    Department of Internal Medicine, Division of Nephrology, University Hospital Groningen, The Netherlands
    Am J Kidney Dis 46:102-10. 2005
    ..However, this method becomes inaccurate when the dynamics of whole-body bicarbonate production change during measurement, as is the case with HD patients during dialysis...
  63. doi request reprint Plasma procalcitonin is associated with obesity, insulin resistance, and the metabolic syndrome
    Ali Abbasi
    Department of Epidemiology, University Medical Center Groningen, Hanzeplein 1, PO Box 30 001, 9700 RB Groningen, The Netherlands
    J Clin Endocrinol Metab 95:E26-31. 2010
    ..Procalcitonin, a well-known biomarker of sepsis and bacterial infections, is produced by adipose tissue and has potential as a marker for chronic low-grade inflammation...
  64. pmc The effect of screening for cardio-renal risk factors on drug use in the general population
    Jarir Atthobari
    Department of Social Pharmacy, Pharmacoepidemiology and Pharmacotherapy, Groningen University for Drug Exploration GUIDE, University of Groningen, Groningen, The Netherlands
    Br J Clin Pharmacol 64:810-8. 2007
    ..To evaluate the effect of a cardio-renal screening programme on desired and undue drug use...
  65. ncbi request reprint Insulin resistance as putative cause of chronic renal transplant dysfunction
    Aiko P J de Vries
    Division of Nephrology Department of Medicine, Groningen University Medical Center, Groningen, The Netherlands
    Am J Kidney Dis 41:859-67. 2003
    ....
  66. doi request reprint N-terminal pro-B-type natriuretic peptide is an independent predictor of cardiovascular morbidity and mortality in the general population
    Gerard C M Linssen
    Department of Cardiology, Thoraxcenter, University Medical Center Groningen, Hanzeplein 1, PO Box 30 001, 9700 RB Groningen, The Netherlands
    Eur Heart J 31:120-7. 2010
    ..However, their prognostic value in the general population is less well established. The purpose of our study was to investigate the prognostic properties of NT-proBNP for death and cardiovascular (CV) events in the general population...
  67. ncbi request reprint The abnormal renal vasodilator response to D1-like receptor stimulation in conscious SHR can be normalized by AT1 blockade
    P A Marcel de Vries
    Departments of Clinical Pharmacology, Groningen University Institute for Drug Exploration GUIDE, State University, Groningen, The Netherlands
    J Cardiovasc Pharmacol 44:571-6. 2004
    ....
  68. ncbi request reprint Do severe systemic sequelae of proteinuria modulate the antiproteinuric response to chronic ACE inhibition?
    Hendrik Bos
    Department of Clinical Pharmacology, Faculty of Medical Sciences and Groningen University Institute of Drug Exploration GUIDE, University of Groningen, The Netherlands
    Nephrol Dial Transplant 17:793-7. 2002
    ..In the present study we therefore investigated whether the severity of systemic nephrosis, estimated from plasma cholesterol, predicts residual proteinuria during ACE inhibition...
  69. ncbi request reprint Renoprotective effects of VPI versus ACEI in normotensive nephrotic rats on different sodium intakes
    Gozewijn D Laverman
    Department of Medicine, Groningen University Institute of Drug Exploration GUIDE, University of Groningen, The Netherlands
    Kidney Int 63:64-71. 2003
    ..Therefore, in contrast with ACEI, VPI may be effective during high sodium intake...
  70. doi request reprint Albuminuria assessed from first-morning-void urine samples versus 24-hour urine collections as a predictor of cardiovascular morbidity and mortality
    Hiddo J Lambers Heerspink
    Department of Clinical Pharmacology, University Medical Center Groningen, P O Box 30 001, 9700 RB Groningen, The Netherlands
    Am J Epidemiol 168:897-905. 2008
    ..To predict cardiovascular morbidity and all-cause mortality, measuring ACR in a first-morning-void urine sample is a good alternative to measuring 24-hour UAE...
  71. ncbi request reprint The metabolic response to ingested protein is normal in long-term hemodialysis patients
    Jorden M Veeneman
    Department of Internal Medicine, Division of Nephrology, University Hospital Groningen, Groningen, The Netherlands
    Am J Kidney Dis 43:330-41. 2004
    ..Protein-energy malnutrition affects 30% to 50% of hemodialysis (HD) patients. This has been attributed to inadequate food intake, but may be caused by disturbances in utilization of ingested protein...
  72. pmc First morning voids are more reliable than spot urine samples to assess microalbuminuria
    Elsbeth C Witte
    Department of Nephrology, University Medical Center Groningen, University of Groningen, Antonius Deusinglaan 1, 9713 AV Groningen, The Netherlands
    J Am Soc Nephrol 20:436-43. 2009
    ..In conclusion, measurement of albuminuria in a first morning void, preferably as the ACR, is more reliable than a spot urine sample to diagnose and monitor microalbuminuria...
  73. ncbi request reprint Dual renin-angiotensin system blockade at optimal doses for proteinuria
    Gozewijn D Laverman
    Division of Nephrology, Faculty of Medical Sciences, University of Groningen, Hanzeplein 1, 9713 GZ Groningen, The Netherlands
    Kidney Int 62:1020-5. 2002
    ..The antiproteinuric effect of combining the angiotensin-converting enzyme (ACE) inhibitor lisinopril and the angiotensin II (Ang II) antagonist losartan was compared to that of the optimal antiproteinuric doses of monotherapy...
  74. ncbi request reprint Drawbacks of the use of indirect estimates of renal function to evaluate the effect of risk factors on renal function
    Jacobien C Verhave
    Division of Nephrology, Department of Medicine, University Medical Center, Groningen, The Netherlands
    J Am Soc Nephrol 15:1316-22. 2004
    ..For studying the relation of risk factors and renal function in large population studies, indirect estimates of renal function should be used with caution...
  75. ncbi request reprint C-reactive protein is associated with renal function abnormalities in a non-diabetic population
    Erik M Stuveling
    Internal Medicine, Trial Coordination Center, Department of Cardiology Thoraxcenter, University Hospital Groningen, and Clinical Pharmacology, University of Groningen, Groningen, The Netherlands
    Kidney Int 63:654-61. 2003
    ..We hypothesized that elevated CRP levels are associated with renal function abnormalities...
  76. ncbi request reprint Effects of fosinopril and pravastatin on carotid intima-media thickness in subjects with increased albuminuria
    Folkert W Asselbergs
    Department of Clinical Pharmacology, University of Groningen, Antonius Deusinglaan 1, 9713 AV, Groningen, The Netherlands
    Stroke 36:649-53. 2005
    ....
  77. ncbi request reprint Urinary albumin excretion predicts cardiovascular and noncardiovascular mortality in general population
    Hans L Hillege
    Trial Coordination Center, Department of Cardiology, University Hospital of Groningen, Groningen, The Netherlands
    Circulation 106:1777-82. 2002
    ..Therefore, we examined the relationship between urinary albumin excretion and all-cause mortality and mortality caused by cardiovascular (CV) disease and non-CV disease in the general population...
  78. pmc The impact of antihypertensive drug groups on urinary albumin excretion in a non-diabetic population
    Taco B M Monster
    Department of Social Pharmacy and Pharmacoepidemiology, Division of Nephrology, Groningen University Institute for Drug Exploration GUIDE, A Deisinglaan 1, 9713 AV Groningen, The Netherlands
    Br J Clin Pharmacol 53:31-6. 2002
    ..Antihypertensives may lower microalbuminuria. We questioned whether the use of different antihypertensive drug classes in general practice influences microalbuminuria as related to blood pressure in nondiabetic subjects...
  79. ncbi request reprint Cardiovascular risk factors are differently associated with urinary albumin excretion in men and women
    Jacobien C Verhave
    Division of Nephrology, Department of Medicine, University Medical Center Groningen, Groningen University Institute of Drug Exploration GUIDE, Hanzeplein 1, 9713 GZ Groningen, The Netherlands
    J Am Soc Nephrol 14:1330-5. 2003
    ..It is concluded that gender differences exist in the association between cardiovascular risk factors and UAE. This is consistent with a larger vascular susceptibility to these risk factors in men as compared with women...
  80. doi request reprint Association of urinary biomarkers with disease severity in patients with autosomal dominant polycystic kidney disease: a cross-sectional analysis
    Esther Meijer
    Division of Nephrology, Department of Internal Medicine, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    Am J Kidney Dis 56:883-95. 2010
    ....
  81. ncbi request reprint Accumulation of advanced glycation end products, measured as skin autofluorescence, in renal disease
    Jasper W L Hartog
    Department of Medicine, Groningen University Medical Center, P O Box 30 001, 9700 RB Groningen, The Netherlands
    Ann N Y Acad Sci 1043:299-307. 2005
    ..The availability of a simple, noninvasive method (AGE-Reader) to measure AGE accumulation may be used to monitor AGE accumulation in a clinical setting as well as in a study setting...
  82. pmc The impact of hormonal contraceptives on blood pressure, urinary albumin excretion and glomerular filtration rate
    Jarir Atthobari
    Department of Social Pharmacy, Pharmacoepidemiology and Pharmacotherapy, Groningen University for Drug Exploration GUIDE, Groningen, The Netherlands
    Br J Clin Pharmacol 63:224-31. 2007
    ..Data on long-term and withdrawal effects of HC use on these outcomes are, however, not available. We therefore studied whether the start and cessation of HC induce changes in BP, UAE and GFR...
  83. ncbi request reprint C-reactive protein and microalbuminuria differ in their associations with various domains of vascular disease
    Erik M Stuveling
    Department of Internal Medicine, University Medical Centre Groningen, Groningen, The Netherlands
    Atherosclerosis 172:107-14. 2004
    ..Thus, CRP and MA are risk markers for vascular disease, each showing a different risk profiling for different vascular beds...
  84. pmc The effect of hypertension and hypercholesterolemia screening with subsequent intervention letter on the use of blood pressure and lipid lowering drugs
    Jarir Atthobari
    Department of Social Pharmacy, Groningen University Institute for Drug Exploration GUIDE, Groningen, The Netherlands
    Br J Clin Pharmacol 57:328-36. 2004
    ..We also tested what predicting variables influenced the GP to actually prescribe blood pressure lowering drugs (BPLD) or lipid lowering drugs (LLD)...
  85. ncbi request reprint Macroalbuminuria is a better risk marker than low estimated GFR to identify individuals at risk for accelerated GFR loss in population screening
    Nynke Halbesma
    Division of Nephrology, Department of Medicine, University Medical Center Groningen, P O Box 30 001, 9700 RB Groningen, The Netherlands
    J Am Soc Nephrol 17:2582-90. 2006
    ..However, macroalbuminuria is a better risk marker than low eGFR or erythrocyturia to identify in population screening of individuals who are at risk for accelerated GFR loss...
  86. ncbi request reprint The effect of cholesteryl ester transfer protein -629C->A promoter polymorphism on high-density lipoprotein cholesterol is dependent on serum triglycerides
    Susanna E Borggreve
    Department of Endocrinology, University Medical Centre Groningen, P O Box 30 001, 9700 RB Groningen, The Netherlands
    J Clin Endocrinol Metab 90:4198-204. 2005
    ..The effect of the closely linked CETP TaqIB polymorphism on HDL-C has been suggested to be modified by obesity and hyperinsulinemia...
  87. ncbi request reprint Social participation and employment status after kidney transplantation: a systematic review
    Sijrike F van der Mei
    Department of Health Sciences, Northern Centre for Healthcare Research NCH, University Medical Centre Groningen UMCG, University of Groningen, P O Box 196, 9700 AD, Groningen, The Netherlands
    Qual Life Res 15:979-94. 2006
    ..To summarize and assess literature regarding social participation of recipients after successful kidney transplantation...
  88. doi request reprint Selection on albuminuria enhances the efficacy of screening for cardiovascular risk factors
    Akin Ozyilmaz
    Division of Nephrology, Department of Medicine, University Medical Center Groningen and University of Groningen, Groningen, The Netherlands
    Nephrol Dial Transplant 25:3560-8. 2010
    ..As albuminuria is easy to measure, we tested whether a screening approach in which detailed risk factor measurement is done only after selection of subjects with an elevated albuminuria results in a higher yield of subjects at risk...
  89. ncbi request reprint Automatic feedback control of relative blood volume changes during hemodialysis improves blood pressure stability during and after dialysis
    Casper F M Franssen
    Dialysis Center Groningen, Department of Internal Medicine, Division of Nephrology, University Medical Center Groningen and University of Groningen, Groningen, The Netherlands
    Hemodial Int 9:383-92. 2005
    ..05). The use of BVT in hypotension-prone patients is associated with higher systolic blood pressures for as long as 16 hr post-HD. BVT was not effective in reducing the post-HD target weight in this patient group...
  90. ncbi request reprint Factors determining social participation in the first year after kidney transplantation: a prospective study
    Sijrike F van der Mei
    Northern Center for Healthcare Research, University Medical Center Groningen, University of Groningen, The Netherlands
    Transplantation 84:729-37. 2007
    ....
  91. ncbi request reprint Metabolic syndrome is associated with impaired long-term renal allograft function; not all component criteria contribute equally
    Aiko P J de Vries
    Renal Transplant Program, Groningen University Medical Center, Groningen, The Netherlands
    Am J Transplant 4:1675-83. 2004
    ..Only systolic blood pressure and hypertriglyceridemia were independently associated with impaired renal allograft function beyond 1 year post-transplant in multivariate analyses...
  92. ncbi request reprint Better understanding of ADPKD results in potential new treatment options: ready for the cure?
    Esther Meijer
    Division of Nephrology, Department of Internal Medicine, University Medical Center Groningen, Groningen, The Netherlands
    J Nephrol 21:133-8. 2008
    ..Clinical trials have been started to investigate the efficacy and safety of these agents for treating ADPKD in humans...
  93. doi request reprint Screening and monitoring for albuminuria: the performance of the HemoCue point-of-care system
    Hiddo J Lambers Heerspink
    Department of Clinical Pharmacology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    Kidney Int 74:377-83. 2008
    ....
  94. doi request reprint Challenges for the present CKD classification system
    Ron T Gansevoort
    Department of Nephrology, University Medical Center Groningen, Groningen, The Netherlands
    Curr Opin Nephrol Hypertens 19:308-14. 2010
    ..This classification system was immediately widely embraced. However, soon after its introduction concerns were expressed. In this review we discuss the major points of concern that have been brought forward...
  95. ncbi request reprint Factors influencing serum cystatin C levels other than renal function and the impact on renal function measurement
    Eric L Knight
    Channing Laboratory, Renal Division, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, USA
    Kidney Int 65:1416-21. 2004
    ....
  96. ncbi request reprint The rate of progression of renal disease may not be slower in women compared with men: a patient-level meta-analysis
    Tazeen H Jafar
    New England Medical Center, Tufts University School of Medicine, Boston, MA, USA
    Nephrol Dial Transplant 18:2047-53. 2003
    ..Therefore, we undertook this analysis to explore the independent association of renal disease progression with gender...
  97. ncbi request reprint Addition of AT1 blocker fails to overcome resistance to ACE inhibition in adriamycin nephrosis
    Hendrik Bos
    Department of Clinical Pharmacology, Faculty of Medical Sciences and Groningen University Institute of Drug Exploration GUIDE, University of Groningen, Groningen, The Netherlands
    Kidney Int 61:473-80. 2002
    ..We studied whether co-treatment with an angiotensin II subtype 1 (AT1) receptor antagonist (AII-A) improves the individual antiproteinuric response of maximal ACE inhibition in established adriamycin nephrosis...
  98. ncbi request reprint Measurement of relative blood volume changes during haemodialysis: merits and limitations
    Judith J Dasselaar
    Dialysis Center Groningen, Hanzeplein 1, 9713 GZ Groningen, The Netherlands
    Nephrol Dial Transplant 20:2043-9. 2005
  99. ncbi request reprint Cost-effectiveness of screening for proteinuria
    Ron T Gansevoort
    JAMA 291:1442-3; author reply 1443. 2004
  100. ncbi request reprint Predictors of angiotensin-converting enzyme inhibitor-induced reduction of urinary albumin excretion in nondiabetic patients
    Ruud M A van de Wal
    St Antonius Hospital, Department of Cardiology, Koekoekslaan 1, 3435 CM, Nieuwegein, The Netherlands
    Hypertension 48:870-6. 2006
    ....
  101. ncbi request reprint Early detection of progressive chronic kidney disease: is it feasible?
    Ron T Gansevoort
    J Am Soc Nephrol 17:1218-20. 2006