Marco de Bruyn

Summary

Affiliation: University Medical Center Groningen
Country: The Netherlands

Publications

  1. pmc Frequency of Th17 CD20+ cells in the peripheral blood of rheumatoid arthritis patients is higher compared to healthy subjects
    Paul Eggleton
    Peninsula Medical School, University of Exeter, Heavitree Road, Exeter EX1 2LU, UK
    Arthritis Res Ther 13:R208. 2011
  2. pmc Melanoma-associated Chondroitin Sulfate Proteoglycan (MCSP)-targeted delivery of soluble TRAIL potently inhibits melanoma outgrowth in vitro and in vivo
    Marco de Bruyn
    Surgical Research Laboratories, Department of Surgery, University Medical Center Groningen Hanzeplein 1, University of Groningen, Groningen 9713 GZ, The Netherlands
    Mol Cancer 9:301. 2010
  3. pmc Carbon monoxide-releasing molecule-2 (CORM-2) attenuates acute hepatic ischemia reperfusion injury in rats
    Yunwei Wei
    Third Department of General Surgery, First Clinical Hospital Harbin, Harbin Medical University, Harbin 150001, Heilongjiang, China
    BMC Gastroenterol 10:42. 2010
  4. doi request reprint Cell surface delivery of TRAIL strongly augments the tumoricidal activity of T cells
    Marco de Bruyn
    Department of Surgery, Surgical Research Laboratories, University Medical Center Groningen UMCG, University of Groningen, Groningen, The Netherlands
    Clin Cancer Res 17:5626-37. 2011
  5. doi request reprint Antibody-based fusion proteins to target death receptors in cancer
    Marco de Bruyn
    Department of Surgery, Surgical Research Laboratories, University Medical Center Groningen, University of Groningen, Hanzeplein 1, 9713 GZ Groningen, The Netherlands
    Cancer Lett 332:175-83. 2013
  6. doi request reprint In vivo responses of human A375M melanoma to a σ ligand: 18F-FDG PET imaging
    Anna A Rybczynska
    University of Groningen, University Medical Center Groningen, Department of Nuclear Medicine and Molecular Imaging, Groningen, The Netherlands
    J Nucl Med 54:1613-20. 2013
  7. doi request reprint Therapeutic potential of Galectin-9 in human disease
    Valerie R Wiersma
    Department of Surgery, Surgical Research Laboratories, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    Med Res Rev 33:E102-26. 2013
  8. pmc Targeted delivery of CD40L promotes restricted activation of antigen-presenting cells and induction of cancer cell death
    Kim L Brunekreeft
    Department of Obstetrics and Gynecology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands
    Mol Cancer 13:85. 2014
  9. doi request reprint Selective elimination of pathogenic synovial fluid T-cells from rheumatoid arthritis and juvenile idiopathic arthritis by targeted activation of Fas-apoptotic signaling
    Edwin Bremer
    Department of Surgery, Surgical Research Laboratory, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    Immunol Lett 138:161-8. 2011

Collaborators

  • Anna A Rybczynska
  • Aren van Waarde
  • Philip H Elsinga
  • Wayel H Abdulahad
  • Harald Wajant
  • Edwin Bremer
  • Wijnand Helfrich
  • Kim L Brunekreeft
  • Valerie R Wiersma
  • Paul Eggleton
  • Yunwei Wei
  • Corinna Strohm
  • Daniela Siegmund
  • Götz U Grigoleit
  • Marloes J Gooden
  • Hans W Nijman
  • Richard C Haigh
  • Alexandra Kendall
  • Nick J Viner
  • Cees G M Kallenberg
  • Joanna M Tarr
  • Douwe F Samplonius
  • E Brouwers
  • Paul G Winyard
  • Wineke Armbrust
  • Ping Chen
  • Weihui Zhang

Detail Information

Publications9

  1. pmc Frequency of Th17 CD20+ cells in the peripheral blood of rheumatoid arthritis patients is higher compared to healthy subjects
    Paul Eggleton
    Peninsula Medical School, University of Exeter, Heavitree Road, Exeter EX1 2LU, UK
    Arthritis Res Ther 13:R208. 2011
    ..g., anti-CD20 antibodies, to alleviate RA is unclear. This study examined the proportions of IL-17-secreting lymphocytes in the blood of healthy subjects and RA patients and determined if Th17 cells belong to a CD20+ subset of T cells...
  2. pmc Melanoma-associated Chondroitin Sulfate Proteoglycan (MCSP)-targeted delivery of soluble TRAIL potently inhibits melanoma outgrowth in vitro and in vivo
    Marco de Bruyn
    Surgical Research Laboratories, Department of Surgery, University Medical Center Groningen Hanzeplein 1, University of Groningen, Groningen 9713 GZ, The Netherlands
    Mol Cancer 9:301. 2010
    ..Anti-MCSP:TRAIL was designed to 1. selectively accrete at the cell surface of MCSP-positive melanoma cells and inhibit MCSP tumorigenic signaling and 2. activate apoptotic TRAIL-signaling...
  3. pmc Carbon monoxide-releasing molecule-2 (CORM-2) attenuates acute hepatic ischemia reperfusion injury in rats
    Yunwei Wei
    Third Department of General Surgery, First Clinical Hospital Harbin, Harbin Medical University, Harbin 150001, Heilongjiang, China
    BMC Gastroenterol 10:42. 2010
    ..Here, we assessed whether CO released from CORM-2 protects against hepatic I/Ri in a rat model...
  4. doi request reprint Cell surface delivery of TRAIL strongly augments the tumoricidal activity of T cells
    Marco de Bruyn
    Department of Surgery, Surgical Research Laboratories, University Medical Center Groningen UMCG, University of Groningen, Groningen, The Netherlands
    Clin Cancer Res 17:5626-37. 2011
    ..Here, we present a novel strategy designed to selectively enhance the tumoricidal activity of T cells by targeted delivery of TNF-related apoptosis-inducing ligand (TRAIL) to the T-cell surface...
  5. doi request reprint Antibody-based fusion proteins to target death receptors in cancer
    Marco de Bruyn
    Department of Surgery, Surgical Research Laboratories, University Medical Center Groningen, University of Groningen, Hanzeplein 1, 9713 GZ Groningen, The Netherlands
    Cancer Lett 332:175-83. 2013
    ..Importantly, off-target binding by scFv:sTRAIL to normal cells showed no signs of toxicity. In this review, we highlight the rationale and perspectives of scFv:TRAIL/scFv:sFasL based fusion proteins for cancer therapy...
  6. doi request reprint In vivo responses of human A375M melanoma to a σ ligand: 18F-FDG PET imaging
    Anna A Rybczynska
    University of Groningen, University Medical Center Groningen, Department of Nuclear Medicine and Molecular Imaging, Groningen, The Netherlands
    J Nucl Med 54:1613-20. 2013
    ..Here, we aimed to assess whether the σ-ligand rimcazole inhibits growth of A375M melanoma xenografts in nude mice and whether rimcazole treatment changes (18)F-FDG uptake in vivo...
  7. doi request reprint Therapeutic potential of Galectin-9 in human disease
    Valerie R Wiersma
    Department of Surgery, Surgical Research Laboratories, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    Med Res Rev 33:E102-26. 2013
    ..Here, we review the biology and physiological role of this versatile lectin and discuss the therapeutic potential of Gal-9 in various diseases, including autoimmunity, asthma, infection, and cancer...
  8. pmc Targeted delivery of CD40L promotes restricted activation of antigen-presenting cells and induction of cancer cell death
    Kim L Brunekreeft
    Department of Obstetrics and Gynecology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands
    Mol Cancer 13:85. 2014
    ..Although CD40 agonists have clinical activity in humans, the associated systemic activation of the immune system triggers dose-limiting side-effects...
  9. doi request reprint Selective elimination of pathogenic synovial fluid T-cells from rheumatoid arthritis and juvenile idiopathic arthritis by targeted activation of Fas-apoptotic signaling
    Edwin Bremer
    Department of Surgery, Surgical Research Laboratory, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    Immunol Lett 138:161-8. 2011
    ..These findings indicate that scFvCD7:sFasL may be of therapeutic value for the selective elimination of pathogenic synovial T-cells of the T(H1) subtype in both RA and JIA...