Jan de Boer

Summary

Affiliation: University of Twente
Country: The Netherlands

Publications

  1. pmc The effect of bone marrow aspiration strategy on the yield and quality of human mesenchymal stem cells
    Eelco M Fennema
    Institute of Biomedical Technology, University of Twente, The Netherlands
    Acta Orthop 80:618-21. 2009
  2. pmc A mesenchymal stromal cell gene signature for donor age
    Hugo Alves
    Department of Tissue Regeneration, MIRA Institute for Biomedical Technology and Technical Medicine, University of Twente, Enschede, The Netherlands
    PLoS ONE 7:e42908. 2012
  3. pmc Endothelial differentiation of mesenchymal stromal cells
    Karolina Janeczek Portalska
    MIRA Institute for Biomedical Technology and Technical Medicine, University of Twente, Enschede, Overijssel, The Netherlands
    PLoS ONE 7:e46842. 2012
  4. ncbi request reprint Wnt signaling inhibits osteogenic differentiation of human mesenchymal stem cells
    Jan de Boer
    Institute for Biomedical Technology, University of Twente, Enschede, The Netherlands
    Bone 34:818-26. 2004
  5. ncbi request reprint Inhibition of histone acetylation as a tool in bone tissue engineering
    Jan de Boer
    Institute of Biomedical Technology, University of Twente, Enschede, The Netherlands
    Tissue Eng 12:2927-37. 2006
  6. ncbi request reprint Effects of Wnt signaling on proliferation and differentiation of human mesenchymal stem cells
    Jan de Boer
    Institute for Biomedical Technology, University of Twente, Twente, The Netherlands
    Tissue Eng 10:393-401. 2004
  7. ncbi request reprint Bioluminescent imaging: emerging technology for non-invasive imaging of bone tissue engineering
    Jan de Boer
    Institute for Biomedical Technology, University of Twente, Prof Bronkhorstlaan 10D, 3723 MB, Bilthoven, The Netherlands
    Biomaterials 27:1851-8. 2006
  8. pmc Delineation of amplification, hybridization and location effects in microarray data yields better-quality normalization
    Marc Hulsman
    Delft Bioinformatics Lab, Delft University of Technology, Mekelweg 4, Delft 2628 CD, The Netherlands
    BMC Bioinformatics 11:156. 2010
  9. doi request reprint The use of endothelial progenitor cells for prevascularized bone tissue engineering
    Jeroen Rouwkema
    Departments of Biomechanical Engineering, Twente University, Enschede, The Netherlands
    Tissue Eng Part A 15:2015-27. 2009
  10. doi request reprint Fabrication of bioactive composite scaffolds by electrospinning for bone regeneration
    Anandkumar Nandakumar
    Department of Tissue Regeneration, MIRA Institute for Biomedical Technology and Technical Medicine, University of Twente, 7500 AE Enschede, PO Box 217, The Netherlands
    Macromol Biosci 10:1365-73. 2010

Collaborators

Detail Information

Publications59

  1. pmc The effect of bone marrow aspiration strategy on the yield and quality of human mesenchymal stem cells
    Eelco M Fennema
    Institute of Biomedical Technology, University of Twente, The Netherlands
    Acta Orthop 80:618-21. 2009
    ..The source of these differences may be clinical differences in stem cell characteristics between individuals or the aspiration procedure itself...
  2. pmc A mesenchymal stromal cell gene signature for donor age
    Hugo Alves
    Department of Tissue Regeneration, MIRA Institute for Biomedical Technology and Technical Medicine, University of Twente, Enschede, The Netherlands
    PLoS ONE 7:e42908. 2012
    ..The gene signature presented here could be a useful tool for drug testing to rejuvenate hMSCs or for the selection of more potent, hMSCs for cell-based therapy...
  3. pmc Endothelial differentiation of mesenchymal stromal cells
    Karolina Janeczek Portalska
    MIRA Institute for Biomedical Technology and Technical Medicine, University of Twente, Enschede, Overijssel, The Netherlands
    PLoS ONE 7:e46842. 2012
    ..To conclude, we established a robust protocol for endothelial differentiation of hMSCs, including an immortalized MSC line (iMSCs) which allows for reproducible in vitro analysis in further studies...
  4. ncbi request reprint Wnt signaling inhibits osteogenic differentiation of human mesenchymal stem cells
    Jan de Boer
    Institute for Biomedical Technology, University of Twente, Enschede, The Netherlands
    Bone 34:818-26. 2004
    ..We conclude that Wnt signaling inhibits dexamethasone-induced osteogenesis in hMSCs. In future studies, we will try to limit release of lithium or Wnt3A from calcium phosphate scaffolds to the proliferative phase of osteogenesis...
  5. ncbi request reprint Inhibition of histone acetylation as a tool in bone tissue engineering
    Jan de Boer
    Institute of Biomedical Technology, University of Twente, Enschede, The Netherlands
    Tissue Eng 12:2927-37. 2006
    ..Finally, we observed that TSA treatment strongly enhanced bone formation of ex vivo cultured mouse calvaria, which warrants further exploration of TSA in bone tissue engineering...
  6. ncbi request reprint Effects of Wnt signaling on proliferation and differentiation of human mesenchymal stem cells
    Jan de Boer
    Institute for Biomedical Technology, University of Twente, Twente, The Netherlands
    Tissue Eng 10:393-401. 2004
    ..Moreover, our data suggest that hMSCs provide a valid in vitro model to study the role of Wnt signaling in mesenchymal biology...
  7. ncbi request reprint Bioluminescent imaging: emerging technology for non-invasive imaging of bone tissue engineering
    Jan de Boer
    Institute for Biomedical Technology, University of Twente, Prof Bronkhorstlaan 10D, 3723 MB, Bilthoven, The Netherlands
    Biomaterials 27:1851-8. 2006
    ..Furthermore, we reflect on technical developments that will make BLI even more promising for future application in bone tissue engineering research...
  8. pmc Delineation of amplification, hybridization and location effects in microarray data yields better-quality normalization
    Marc Hulsman
    Delft Bioinformatics Lab, Delft University of Technology, Mekelweg 4, Delft 2628 CD, The Netherlands
    BMC Bioinformatics 11:156. 2010
    ..Normalization is, however, far from a solved problem. Frequently, we encounter datasets with significant technical effects that currently available methods are not able to correct...
  9. doi request reprint The use of endothelial progenitor cells for prevascularized bone tissue engineering
    Jeroen Rouwkema
    Departments of Biomechanical Engineering, Twente University, Enschede, The Netherlands
    Tissue Eng Part A 15:2015-27. 2009
    ..The degree of organization, however, was higher. We conclude that EPC can be used for complex tissue engineering applications, but the differentiation stage of these cells is important...
  10. doi request reprint Fabrication of bioactive composite scaffolds by electrospinning for bone regeneration
    Anandkumar Nandakumar
    Department of Tissue Regeneration, MIRA Institute for Biomedical Technology and Technical Medicine, University of Twente, 7500 AE Enschede, PO Box 217, The Netherlands
    Macromol Biosci 10:1365-73. 2010
    ..The results of the study demonstrate that bioactive composite scaffolds prepared by electrospinning could find potential use in bone regeneration applications...
  11. doi request reprint Effect of chordin-like 1 on MC3T3-E1 and human mesenchymal stem cells
    Hugo Fernandes
    Department of Tissue Regeneration, University of Twente, Enschede, The Netherlands
    Cells Tissues Organs 191:443-52. 2010
    ..Our data point towards a novel, BMP-independent role of chordin-like 1 in hMSC proliferation...
  12. doi request reprint Molecular mechanisms of biomaterial-driven osteogenic differentiation in human mesenchymal stromal cells
    Ana M C Barradas
    Department of Tissue Regeneration, MIRA Institute for Biomedical Technology and Technical Medicine, University of Twente, Drienerlolaan 5, 7522 NB Enschede, The Netherlands
    Integr Biol (Camb) 5:920-31. 2013
    ..These genes, associated with the protein kinase A and GPCR signaling pathways, may herald the earliest response of MSC to bone-inducing ceramics. ..
  13. doi request reprint Bioinformatics-based selection of a model cell type for in vitro biomaterial testing
    Nathalie Groen
    Department of Tissue Regeneration, MIRA Institute for Biomedical Technology and Technical Medicine, University of Twente, Drienerlolaan 5, Enschede 7500 AE, The Netherlands
    Biomaterials 34:5552-61. 2013
    ..In the next phase, this cell line will be used to identify a target correlating with in vivo biomaterial performance and henceforth to develop an in vitro screening system...
  14. doi request reprint Endogenous collagen influences differentiation of human multipotent mesenchymal stromal cells
    Hugo Fernandes
    Department of Tissue Regeneration, University of Twente, Enschede, The Netherlands
    Tissue Eng Part A 16:1693-702. 2010
    ..In conclusion, the collagenous matrix supports both proliferation and differentiation of osteogenic hMSCs but, on the other hand, presents signals stimulating matrix remodeling and inhibiting osteoclastogenesis...
  15. doi request reprint A newly developed chemically crosslinked dextran-poly(ethylene glycol) hydrogel for cartilage tissue engineering
    Jojanneke M Jukes
    Department of Tissue Regeneration, MIRA Institute for Biomedical Technology and Technical Medicine, University of Twente, Enschede, The Netherlands
    Tissue Eng Part A 16:565-73. 2010
    ..Our data demonstrate the potential of dextran hydrogels for cartilage tissue engineering strategies...
  16. ncbi request reprint cAMP/PKA signaling inhibits osteogenic differentiation and bone formation in rodent models
    Ramakrishnaiah Siddappa
    Department of Tissue Regeneration, Institute for Biomedical Technology, University of Twente, Enschede, The Netherlands
    Tissue Eng Part A 15:2135-43. 2009
    ..The species discrepancy in response to various osteogenic signals is a critical need to be tested in clinically relevant models to translate the fundamental findings in lower species level to clinical applications...
  17. doi request reprint Predicting the therapeutic efficacy of MSC in bone tissue engineering using the molecular marker CADM1
    Anouk Mentink
    University of Twente, MIRA Institute for Biomedical Technology and Technical Medicine, Department of Tissue Regeneration, Drienerlolaan 5, 7522 NB Enschede, The Netherlands
    Biomaterials 34:4592-601. 2013
    ..Our bio-informatics driven approach may be used in other fields of cell therapy to establish diagnostic markers for clinical efficacy...
  18. doi request reprint Surface modifications by gas plasma control osteogenic differentiation of MC3T3-E1 cells
    Ana M C Barradas
    Department of Tissue Regeneration, MIRA Institute for Biomedical Research and Technical Medicine, University of Twente, PO Box 217, 7500 AE Enschede, The Netherlands
    Acta Biomater 8:2969-77. 2012
    ..This promising surface modification could be further explored for potential development of bone graft substitutes...
  19. ncbi request reprint In vitro and in vivo bioluminescent imaging of hypoxia in tissue-engineered grafts
    Jun Liu
    Department of Tissue Regeneration, University of Twente, Enschede, The Netherlands
    Tissue Eng Part C Methods 16:479-85. 2010
    ..We conclude that this reporter system is a versatile tool to investigate cellular O(2) availability in TE both in vitro and in vivo...
  20. doi request reprint The role of collagen crosslinking in differentiation of human mesenchymal stem cells and MC3T3-E1 cells
    Hugo Fernandes
    Department of Tissue Regeneration, University of Twente, Enschede, The Netherlands
    Tissue Eng Part A 15:3857-67. 2009
    ..In conclusion, collagen crosslinking harbors instructive properties in MC3T3-E1 differentiation but plays a more-passive role in differentiation of bone marrow-derived hMSCs...
  21. ncbi request reprint Donor variation and loss of multipotency during in vitro expansion of human mesenchymal stem cells for bone tissue engineering
    Ramakrishnaiah Siddappa
    Institute for Biomedical Technology, Department of Tissue Regeneration, University of Twente, Zuidhorst, P O Box 217, Enschede 7500 AE, The Netherlands
    J Orthop Res 25:1029-41. 2007
    ..The variability in ALP expression appears to be a result of sampling method and cellular heterogeneity among the donor population...
  22. doi request reprint Pro-osteogenic trophic effects by PKA activation in human mesenchymal stromal cells
    Joyce Doorn
    University of Twente, MIRA Institute for Biomedical Engineering and Technical Medicine, Drienerlolaan 5, 7500 AE Enschede, The Netherlands
    Biomaterials 32:6089-98. 2011
    ....
  23. pmc Endochondral bone tissue engineering using embryonic stem cells
    Jojanneke M Jukes
    Institute for Biomedical Technology, Department of Tissue Regeneration, University of Twente, Drienerlolaan 5, 7522 NB, Enschede, The Netherlands
    Proc Natl Acad Sci U S A 105:6840-5. 2008
    ..We report previously undescribed ESC-based bone tissue engineering under controlled reproducible conditions. Furthermore, our data indicate that ESCs can also be used as a model system to study endochondral bone formation...
  24. doi request reprint Engineering new bone via a minimally invasive route using human bone marrow-derived stromal cell aggregates, microceramic particles, and human platelet-rich plasma gel
    Anindita Chatterjea
    Department of Tissue Regeneration, MIRA Institute for Biomedical Technology and Technical Medicine, University of Twente, Enschede, The Netherlands
    Tissue Eng Part A 19:340-9. 2013
    ....
  25. doi request reprint A calcium-induced signaling cascade leading to osteogenic differentiation of human bone marrow-derived mesenchymal stromal cells
    Ana M C Barradas
    Department of Tissue Regeneration, MIRA Institute for Biomedical Technology and Technical Medicine, University of Twente, Drienerlolaan 5, 7522 NB Enschede, The Netherlands
    Biomaterials 33:3205-15. 2012
    ..We have demonstrated that hMSC osteogenesis can be induced via extracellular Ca(2+), a simple and economic way of priming hMSCs for bone tissue engineering applications...
  26. doi request reprint Streamlining the generation of an osteogenic graft by 3D culture of unprocessed bone marrow on ceramic scaffolds
    Anindita Chatterjea
    University of Twente, MIRA Institute for Biomedical Technology and Technical Medicine, Department of Tissue Regeneration, Enschede, The Netherlands
    J Tissue Eng Regen Med 6:103-12. 2012
    ..We conclude that human osteogenic grafts can be efficiently prepared by direct seeding of cells from unprocessed bone marrow...
  27. doi request reprint The effect of PKC activation and inhibition on osteogenic differentiation of human mesenchymal stem cells
    Jun Liu
    Mira Institute for Biomedical Technology, Department of Tissue Regeneration, University of Twente, Enschede, The Netherlands
    J Tissue Eng Regen Med 4:329-39. 2010
    ..In conclusion, inhibition of the conventional PKCs/PKCmicro and activation of PKCdelta could further benefit osteogenic differentiation of hMSCs in vitro and in vivo, which is currently under investigation...
  28. doi request reprint Differential bone-forming capacity of osteogenic cells from either embryonic stem cells or bone marrow-derived mesenchymal stem cells
    Sanne K Both
    Twente University, Institute for Biomedical Technology, Enschede, The Netherlands
    J Tissue Eng Regen Med 5:180-90. 2011
    ....
  29. ncbi request reprint The response of human mesenchymal stem cells to osteogenic signals and its impact on bone tissue engineering
    Ramakrishnaiah Siddappa
    University of Twente, Institute for Biomedical Technology, Department of Tissue Regeneration, P O Box 217, Enschede 7500 AE, The Netherlands
    Curr Stem Cell Res Ther 2:209-20. 2007
    ..We will discuss how and to what extent the process is different from that in other cell types with special emphasis on applications in bone tissue engineering...
  30. pmc A link between the accumulation of DNA damage and loss of multi-potency of human mesenchymal stromal cells
    Hugo Alves
    Department of Tissue Regeneration, MIRA Institute for Biomedical Technology and Technical Medicine, University of Twente, Enschede, The Netherlands
    J Cell Mol Med 14:2729-38. 2010
    ....
  31. doi request reprint Timing, rather than the concentration of cyclic AMP, correlates to osteogenic differentiation of human mesenchymal stem cells
    Ramakrishnaiah Siddappa
    MIRA Institute for Biomedical Technology and Technical Medicine, Department of Tissue Regeneration, University of Twente, Enschede, The Netherlands
    J Tissue Eng Regen Med 4:356-65. 2010
    ..Taken together, our results demonstrate that cAMP can either stimulate or inhibit osteogenesis in hMSCs, depending on the duration, rather than the strength, of the signal provided...
  32. ncbi request reprint Suppression of the immune system as a critical step for bone formation from allogeneic osteoprogenitors implanted in rats
    Anindita Chatterjea
    Department of Tissue Regeneration, MIRA Institute for Biomedical Technology and Technical Medicine, University of Twente, Enschede, The Netherlands
    J Cell Mol Med 18:134-42. 2014
    ..Overall, allografts comprising osteoprogenitors derived from allogeneic MSCs have the potential to be used in bone regeneration applications...
  33. pmc Effect of antioxidant supplementation on the total yield, oxidative stress levels, and multipotency of bone marrow-derived human mesenchymal stromal cells
    Hugo Alves
    Department of Tissue Regeneration, MIRA Institute for Biomedical Technology and Technical Medicine, University of Twente, Enschede, The Netherlands
    Tissue Eng Part A 19:928-37. 2013
    ..Concomitantly, oxidative DNA damage and ROS levels in hMSCs were reduced by antioxidants. We conclude that antioxidant supplementation during MSC expansion reduces the DNA damage load and increases the MSC yield...
  34. doi request reprint Forskolin enhances in vivo bone formation by human mesenchymal stromal cells
    Joyce Doorn
    Department of Tissue Regeneration, MIRA Institute for Biomedical Technology and Technical Medicine, University of Twente, Enschede, The Netherlands
    Tissue Eng Part A 18:558-67. 2012
    ..Our data show forskolin to be a novel agent that can be used to increase bone formation and also suggests a role for PKA in the delicate balance between adipogenic and osteogenic differentiation...
  35. doi request reprint Noninvasive imaging of bone-specific collagen I expression in a luciferase transgenic mouse model
    Jun Liu
    Department of Tissue Regeneration, MIRA Research Institute, University of Twente, Enschede, The Netherlands
    Tissue Eng Part C Methods 16:1297-304. 2010
    ..We conclude that Col(I)-Luc transgenic mice can be applied in the field of bone tissue engineering for monitoring bone repair processes and for investigating osteoinductive molecules or scaffolds...
  36. doi request reprint Effects of the architecture of tissue engineering scaffolds on cell seeding and culturing
    Ferry P W Melchels
    MIRA Institute for Biomedical Technology and Technical Medicine, Department of Polymer Chemistry and Biomaterials, University of Twente, P O Box 217, 7500 AE Enschede, The Netherlands
    Acta Biomater 6:4208-17. 2010
    ..Furthermore, novel scaffold designs are proposed to further improve the transport of oxygen and nutrients throughout the scaffolds and to create tissue engineering grafts with a designed, pre-fabricated vasculature...
  37. ncbi request reprint The effect of donor variation and senescence on endothelial differentiation of human mesenchymal stromal cells
    Karolina Janeczek Portalska
    1 Department of Tissue Regeneration, MIRA Institute for Biomedical Technology and Technical Medicine, University of Twente, Enschede, The Netherlands
    Tissue Eng Part A 19:2318-29. 2013
    ..Our results show the robustness of the endothelial differentiation protocol and the gene expression data give insight in the differences in endothelial differentiation between donors. ..
  38. ncbi request reprint A fast process for imprinting micro and nano patterns on electrospun fiber meshes at physiological temperatures
    Anandkumar Nandakumar
    Department of Tissue Regeneration, MIRA Institute for Biomedical Technology and Technical Medicine, University of Twente, PO Box 217, 7500AE Enschede, The Netherlands
    Small 9:3405-9. 2013
    ..Microgrooved electrospun fibers support upregulation of alkaline phosphatase and bone morphogenetic protein-2 gene expression when cells are cultured in osteogenic medium. ..
  39. ncbi request reprint Endothelial cells assemble into a 3-dimensional prevascular network in a bone tissue engineering construct
    Jeroen Rouwkema
    Institute for Biomedical Technology, University of Twente, Prof Bronkhorstlaan 10D, Bilthoven 3723MB, The Netherlands
    Tissue Eng 12:2685-93. 2006
    ..This finding is a strong indication that in vitro prevascularization is a promising strategy to improve implant vascularization in bone tissue engineering...
  40. ncbi request reprint Insulin-like growth factor-I enhances proliferation and differentiation of human mesenchymal stromal cells in vitro
    Joyce Doorn
    MIRA Institute for Biomedical Technology and Technical Medicine, University of Twente, Enschede, The Netherlands
    Tissue Eng Part A 19:1817-28. 2013
    ..Furthermore, we examined synergistic effects of bone morphogenetic protein-2 (BMP-2) and IGF-1 and, although IGF-1 enhanced BMP-2-induced mineralization, IGF-1 only slightly affected in vivo bone formation. ..
  41. doi request reprint Development and analysis of multi-layer scaffolds for tissue engineering
    Bernke J Papenburg
    Membrane Science and Technology, Faculty of Science and Technology, Institute for Biomedical Technology and Technical Medicine MIRA, University of Twente, P O Box 217, 7500 AE, Enschede, The Netherlands
    Biomaterials 30:6228-39. 2009
    ..Under dynamic conditions, medium flow through the channels improves nutrient availability to the cells on the various layers, drastically increasing cell proliferation on all layers...
  42. pmc An algorithm-based topographical biomaterials library to instruct cell fate
    Hemant V Unadkat
    Department of Tissue Regeneration, MIRA Institute for Biomedical Technology and Technical Medicine, University of Twente, 7500AE, Enschede, The Netherlands
    Proc Natl Acad Sci U S A 108:16565-70. 2011
    ..In conclusion, we demonstrate that randomized libraries of surface topographies can be broadly applied to unravel the interplay between cells and surface topography and to find improved material surfaces...
  43. pmc High-throughput assay for the identification of compounds regulating osteogenic differentiation of human mesenchymal stromal cells
    Hugo Alves
    Department of Tissue Regeneration, MIRA Institute for Biomedical Technology and Technical Medicine, University of Twente, Enschede, The Netherlands
    PLoS ONE 6:e26678. 2011
    ....
  44. pmc cAMP/PKA pathway activation in human mesenchymal stem cells in vitro results in robust bone formation in vivo
    Ramakrishnaiah Siddappa
    Department of Tissue Regeneration, Institute for Biomedical Technology, University of Twente, 7500 AE, Enschede, The Netherlands
    Proc Natl Acad Sci U S A 105:7281-6. 2008
    ..As a consequence, PKA activation results in robust in vivo bone formation by hMSCs derived from orthopedic patients...
  45. ncbi request reprint A rapid and efficient method for expansion of human mesenchymal stem cells
    Sanne K Both
    Institute for Biomedical Technology, University of Twente, Bilthoven, The Netherlands
    Tissue Eng 13:3-9. 2007
    ..On the basis of these results we have developed an efficient method to culture hMSCs by seeding the cells at 100 cells/cm2 in an alpha-minimal essential medium-based medium containing dexamethasone...
  46. doi request reprint Spheroid culture as a tool for creating 3D complex tissues
    Eelco Fennema
    Department of Tissue Regeneration, MIRA Institute for Biomedical Technology and Technical Medicine, University of Twente, Enschede, The Netherlands
    Trends Biotechnol 31:108-15. 2013
    ..Here, we review new possibilities that combine the strengths of spheroid culture with new microenvironment fabrication methods that allow for the creation of large numbers of highly reproducible, complex tissues...
  47. doi request reprint The influence of genetic factors on the osteoinductive potential of calcium phosphate ceramics in mice
    Ana M C Barradas
    Department of Tissue Regeneration, MIRA Institute for Biomedical Technology and Technical Medicine, University of Twente, Drienerlolaan 5, 7522 NB Enschede, The Netherlands
    Biomaterials 33:5696-705. 2012
    ..The mouse model here described can accelerate research of osteoinductive mechanisms triggered by CaP ceramics and potentially the development of therapies for bone regeneration...
  48. doi request reprint Inflammatory response and bone healing capacity of two porous calcium phosphate ceramics in critical size cortical bone defects
    Anindita Chatterjea
    Department of Tissue Regeneration, MIRA Institute for Biomedical Technology and Technical Medicine, University of Twente, Enschede, The Netherlands
    J Biomed Mater Res A 102:1399-407. 2014
    ..In conclusion, the two ceramics differed in the amount of bone formed after 8 weeks of implantation, whereas no differences were found in the duration of the inflammatory phase after implantation or initiation of new bone formation...
  49. ncbi request reprint Fiber diameter and texture of electrospun PEOT/PBT scaffolds influence human mesenchymal stem cell proliferation and morphology, and the release of incorporated compounds
    Lorenzo Moroni
    Institute for Biomedical Technology BMTI, University of Twente, P O Box 217, 7500 AE Enschede, The Netherlands
    Biomaterials 27:4911-22. 2006
    ....
  50. doi request reprint A small molecule approach to engineering vascularized tissue
    Joyce Doorn
    MIRA Institute for Biomedical Technology and Technical Medicine, Department of Tissue Regeneration, University of Twente, Enschede, The Netherlands
    Biomaterials 34:3053-63. 2013
    ..We showed that phenanthroline alone was sufficient to induce blood vessel formation in a Matrigel plug assay in vivo paving the way to its application in ischeamic-related diseases...
  51. doi request reprint Diverse effects of cyclic AMP variants on osteogenic and adipogenic differentiation of human mesenchymal stromal cells
    Joyce Doorn
    Department of Tissue Regeneration, MIRA Institute for Biomedical Technology and Technical Medicine, University of Twente, Enschede, The Netherlands
    Tissue Eng Part A 18:1431-42. 2012
    ....
  52. doi request reprint Critical Steps toward a tissue-engineered cartilage implant using embryonic stem cells
    Jojanneke M Jukes
    Department of Tissue Regeneration, Institute for Biomedical Technology, University of Twente, Enschede, The Netherlands
    Tissue Eng Part A 14:135-47. 2008
    ..We conclude that ES cells can be used as a cell source for cartilage tissue engineering, pending further optimization of the strategy...
  53. doi request reprint Skeletal tissue engineering using embryonic stem cells
    Jojanneke M Jukes
    MIRA Institute for Biomedical Technology and Technical Medicine, Department of Tissue Regeneration, University of Twente, Enschede, The Netherlands
    J Tissue Eng Regen Med 4:165-80. 2010
    ..In conclusion, there are still many challenges, but there is potential for ESCs in skeletal tissue engineering...
  54. pmc Fabrication of cell container arrays with overlaid surface topographies
    Roman Truckenmüller
    MIRA Institute for Biomedical Technology and Technical Medicine, Department of Tissue Regeneration, University of Twente, Drienerlolaan 5, 7522 NB, Enschede, The Netherlands
    Biomed Microdevices 14:95-107. 2012
    ..In future stem-cell-biological and tissue engineering applications, microcontainers fabricated using the proposed technology may act as geometrically defined artificial microenvironments or niches...
  55. ncbi request reprint Tissue assembly and organization: developmental mechanisms in microfabricated tissues
    Nicolas C Rivron
    Department of Tissue Regeneration, Institute for Biomedical Technology, University of Twente, Zuidhorst, P O Box 217, Enschede 7500 AE, The Netherlands
    Biomaterials 30:4851-8. 2009
    ....
  56. doi request reprint Boosting angiogenesis and functional vascularization in injectable dextran-hyaluronic acid hydrogels by endothelial-like mesenchymal stromal cells
    Karolina Janeczek Portalska
    1 Department of Tissue Regeneration, MIRA Institute for Biomedical Technology and Technical Medicine, University of Twente, Enschede, The Netherlands
    Tissue Eng Part A 20:819-29. 2014
    ..This work demonstrates that Dex-g-HA is an efficient delivery method of VEGF to induce angiogenesis. Additionally, functional neovascularization can be achieved in vitro and in vivo by the combination of Dex-g-HA with EL-MSC. ..
  57. doi request reprint Therapeutic applications of mesenchymal stromal cells: paracrine effects and potential improvements
    Joyce Doorn
    Department of Tissue Regeneration, MIRA Institute for Biomedical Technology and Technical Medicine, University of Twente, Enschede, The Netherlands
    Tissue Eng Part B Rev 18:101-15. 2012
    ..We will then evaluate therapeutic applications that currently try to utilize the trophic and/or immunomodulatory properties of MSCs, and we will also discuss new options to enhance their therapeutic effects...
  58. pmc Clinical application of human mesenchymal stromal cells for bone tissue engineering
    Anindita Chatterjea
    Department of Tissue Regeneration, MIRA Institute for Biomedical Technology and Technical Medicine, University of Twente, 7500 Enschede, The Netherlands
    Stem Cells Int 2010:215625. 2010
    ....
  59. ncbi request reprint Physicochemical composition of osteoporotic bone in the trichothiodystrophy premature aging mouse determined by confocal Raman microscopy
    Aart A van Apeldoorn
    Department of Polymer Chemistry and Biomaterials, Faculty of Technology and Sciences, University of Twente, PO Box 98, 3720 AB Bilthoven, The Netherlands
    J Gerontol A Biol Sci Med Sci 62:34-40. 2007
    ..In contrast, the bands representing the bone protein matrix were not affected in these mice...