Gerald de Haan

Summary

Affiliation: University of Groningen
Country: The Netherlands

Publications

  1. ncbi request reprint Distinct functional properties of highly purified hematopoietic stem cells from mouse strains differing in stem cell numbers
    G de Haan
    Department of Cell Biology, University of Groningen, The Netherlands
    Blood 96:1374-9. 2000
  2. ncbi request reprint A genetic and genomic approach to identify longevity genes in mice
    Gerald de Haan
    Department of Stem Cell Biology, University of Groningen, Antonius Deusinglaan 1, 9713 AV Groningen, The Netherlands
    Mech Ageing Dev 126:133-8. 2005
  3. ncbi request reprint In vitro generation of long-term repopulating hematopoietic stem cells by fibroblast growth factor-1
    Gerald de Haan
    Department of Stem Cell Biology, University of Groningen, A Deusinglaan 1, 9713 AV Groningen, The Netherlands
    Dev Cell 4:241-51. 2003
  4. ncbi request reprint A genetic and genomic analysis identifies a cluster of genes associated with hematopoietic cell turnover
    Gerald de Haan
    Department of Stem Cell Biology, University of Groningen, A Deusinglaan 1, 9713 AV Groningen, The Netherlands
    Blood 100:2056-62. 2002
  5. ncbi request reprint Hematopoietic stem cells: self-renewing or aging?
    Gerald de Haan
    Department of Stem Cell Biology, University of Groningen, Groningen, The Netherlands
    Cells Tissues Organs 171:27-37. 2002
  6. ncbi request reprint Efficient mobilization of haematopoietic progenitors after a single injection of pegylated recombinant human granulocyte colony-stimulating factor in mouse strains with distinct marrow-cell pool sizes
    G de Haan
    Department of Cell Biology, University of Groningen, Groningen, The Netherlands
    Br J Haematol 110:638-46. 2000
  7. ncbi request reprint A Limited role for p21Cip1/Waf1 in maintaining normal hematopoietic stem cell functioning
    Ronald van Os
    Department of Cell Biology, Section Stem Cell Biology, University Medical Center Groningen, A Deusinglaan 1, 9713 AV Groningen, Groningen, The Netherlands
    Stem Cells 25:836-43. 2007
  8. doi request reprint The combination of valproic acid and lithium delays hematopoietic stem/progenitor cell differentiation
    Marta A Walasek
    Department of Cell Biology, Section Stem Cell Biology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    Blood 119:3050-9. 2012
  9. doi request reprint Cellular barcoding tool for clonal analysis in the hematopoietic system
    Alice Gerrits
    Department of Cell Biology, Section Stem Cell Biology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    Blood 115:2610-8. 2010
  10. ncbi request reprint Identification of quantitative trait loci regulating haematopoietic parameters in B6AKRF2 mice
    Ronald van Os
    Department of Cell Biology, Section Stem Cell Biology, University Medical Centre Groningen, Groningen, The Netherlands
    Br J Haematol 132:80-90. 2006

Collaborators

Detail Information

Publications51

  1. ncbi request reprint Distinct functional properties of highly purified hematopoietic stem cells from mouse strains differing in stem cell numbers
    G de Haan
    Department of Cell Biology, University of Groningen, The Netherlands
    Blood 96:1374-9. 2000
    ..Such genetically determined quantitative and qualitative differences in stem cell behavior likely contribute to the dramatically different hematopoietic recovery rates observed in human transplant patients. (Blood. 2000;96:1374-1379)..
  2. ncbi request reprint A genetic and genomic approach to identify longevity genes in mice
    Gerald de Haan
    Department of Stem Cell Biology, University of Groningen, Antonius Deusinglaan 1, 9713 AV Groningen, The Netherlands
    Mech Ageing Dev 126:133-8. 2005
    ..As a proof of principle we describe preliminary studies in which variation in gene expression patterns in hematopoietic stem cells and brain were genetically linked to longevity...
  3. ncbi request reprint In vitro generation of long-term repopulating hematopoietic stem cells by fibroblast growth factor-1
    Gerald de Haan
    Department of Stem Cell Biology, University of Groningen, A Deusinglaan 1, 9713 AV Groningen, The Netherlands
    Dev Cell 4:241-51. 2003
    ..Our results show that the multipotential properties of stem cells are dependent on signaling through FGF receptors and that FGF-1 plays an important role in hematopoietic stem cell homeostasis...
  4. ncbi request reprint A genetic and genomic analysis identifies a cluster of genes associated with hematopoietic cell turnover
    Gerald de Haan
    Department of Stem Cell Biology, University of Groningen, A Deusinglaan 1, 9713 AV Groningen, The Netherlands
    Blood 100:2056-62. 2002
    ..Our data are consistent with the hypothesis that this isolated cell cycle QTL does not result from a mutation in a single gene but rather is a consequence of variable expression of a collection of highly linked genes...
  5. ncbi request reprint Hematopoietic stem cells: self-renewing or aging?
    Gerald de Haan
    Department of Stem Cell Biology, University of Groningen, Groningen, The Netherlands
    Cells Tissues Organs 171:27-37. 2002
    ..Although the mechanisms regulating stem cell plasticity are far from clear, it is challenging to discuss the potential relevance of these findings in the aging process...
  6. ncbi request reprint Efficient mobilization of haematopoietic progenitors after a single injection of pegylated recombinant human granulocyte colony-stimulating factor in mouse strains with distinct marrow-cell pool sizes
    G de Haan
    Department of Cell Biology, University of Groningen, Groningen, The Netherlands
    Br J Haematol 110:638-46. 2000
    ..Comparison of the AKXL strain distribution pattern for marrow cellularity with loci previously mapped in these strains showed complete concordance with Aat, a serine protease inhibitor mapping to chromosome 12...
  7. ncbi request reprint A Limited role for p21Cip1/Waf1 in maintaining normal hematopoietic stem cell functioning
    Ronald van Os
    Department of Cell Biology, Section Stem Cell Biology, University Medical Center Groningen, A Deusinglaan 1, 9713 AV Groningen, Groningen, The Netherlands
    Stem Cells 25:836-43. 2007
    ..Cumulatively, our data fail to support the notion that p21 is essential for stem cell function during steady-state hematopoiesis, but may be relatively more important under conditions of cellular stress...
  8. doi request reprint The combination of valproic acid and lithium delays hematopoietic stem/progenitor cell differentiation
    Marta A Walasek
    Department of Cell Biology, Section Stem Cell Biology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    Blood 119:3050-9. 2012
    ....
  9. doi request reprint Cellular barcoding tool for clonal analysis in the hematopoietic system
    Alice Gerrits
    Department of Cell Biology, Section Stem Cell Biology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    Blood 115:2610-8. 2010
    ..This cellular barcoding tool permits a simple, sensitive assessment of clonality and holds great promise for future gene therapy protocols in humans, and any other applications when clonal tracking is important...
  10. ncbi request reprint Identification of quantitative trait loci regulating haematopoietic parameters in B6AKRF2 mice
    Ronald van Os
    Department of Cell Biology, Section Stem Cell Biology, University Medical Centre Groningen, Groningen, The Netherlands
    Br J Haematol 132:80-90. 2006
    ..Surprisingly, stem and progenitor cell pool size and proliferation rate, as well as peripheral blood cell counts are all independently regulated...
  11. doi request reprint Engraftment of syngeneic bone marrow is not more efficient after intrafemoral transplantation than after traditional intravenous administration
    Ronald van Os
    Department of Cell Biology, Section Stem Cell Biology, University Medical Center Groningen, University of Groningen, The Netherlands
    Exp Hematol 38:1115-23. 2010
    ..Here, we investigated in a syngeneic mouse model whether engraftment and reconstitution can be improved by transplantation directly into the bone marrow...
  12. doi request reprint Repression of BMI1 in normal and leukemic human CD34(+) cells impairs self-renewal and induces apoptosis
    Aleksandra Rizo
    Department of Cell Biology, Section Stem Cell Biology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands
    Blood 114:1498-505. 2009
    ..Together our data indicate that BMI1 expression is required for maintenance and self-renewal of normal and leukemic stem and progenitor cells, and that expression of BMI1 protects cells against oxidative stress...
  13. ncbi request reprint Impaired hematopoietic stem cell functioning after serial transplantation and during normal aging
    Leonie M Kamminga
    University of Groningen, Department of Stem Cell Biology, Antonius Deusinglaan 1, 9713 AV Groningen, The Netherlands
    Stem Cells 23:82-92. 2005
    ..Our data clearly establish the relevance of an intrinsic, genetically controlled program associated with impaired stem cell functioning during aging...
  14. pmc Expression quantitative trait loci are highly sensitive to cellular differentiation state
    Alice Gerrits
    Department of Cell Biology, Section Stem Cell Biology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    PLoS Genet 5:e1000692. 2009
    ..Therefore, future genetical genomics studies should aim at studying multiple well-defined and highly purified cell types in order to construct as comprehensive a picture of the changing functional regulatory relationships as possible...
  15. ncbi request reprint Fibroblast growth factor-1 and -2 preserve long-term repopulating ability of hematopoietic stem cells in serum-free cultures
    Joyce S G Yeoh
    Department of Cell Biology, Section Stem Cell Biology, University Medical Centre Groningen, Antonius, The Netherlands
    Stem Cells 24:1564-72. 2006
    ..Importantly, although HSC activity is typically rapidly lost after short-term culture in vitro, our current protocol allows us to sustain stem cell repopulation potential for periods up to 5 weeks...
  16. doi request reprint Polycomb Cbx family members mediate the balance between haematopoietic stem cell self-renewal and differentiation
    Karin Klauke
    European Institute for the Biology of Ageing ERIBA, Section Ageing Biology and Stem Cells, University Medical Centre Groningen, University of Groningen, Groningen 9700 AD, The Netherlands
    Nat Cell Biol 15:353-62. 2013
    ..Taken together, the presence of distinct Cbx proteins confers target selectivity to PRC1 and provides a molecular balance between self-renewal and differentiation of HSCs...
  17. doi request reprint Counting stem cells: methodological constraints
    Leonid V Bystrykh
    Laboratory of Stem Cell Research, European Research Institute for the Biology of Ageing, University Medical Center Groningen, University of Groningen, The Netherlands
    Nat Methods 9:567-74. 2012
    ..We discuss how restriction enzyme choice, PCR bias, high-throughput sequencing depth and tagging method could affect the conclusions of clonal studies...
  18. ncbi request reprint Chemotherapy prior to autologous bone marrow transplantation impairs long-term engraftment in mice
    Estelle J K Noach
    Department of Stem Cell Biology, University of Groningen, University Hospital Groningen, A Deusinglaan 1, NL 9713 AV Groningen, The Netherlands
    Exp Hematol 31:528-34. 2003
    ..Autologous bone marrow transplantation in cancer patients is often preceded by multiple cycles of chemotherapy. In this study, we assessed in a mouse model whether stem cells were affected by prior chemotherapy...
  19. doi request reprint Keratinocyte growth factor prevents radiation damage to salivary glands by expansion of the stem/progenitor pool
    Isabelle M A Lombaert
    Department of Cell Biology, Section Radiation and Stress Cell Biology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    Stem Cells 26:2595-601. 2008
    ..Disclosure of potential conflicts of interest is found at the end of this article...
  20. doi request reprint Genetic screen identifies microRNA cluster 99b/let-7e/125a as a regulator of primitive hematopoietic cells
    Alice Gerrits
    Department of Cell Biology, Section Stem Cell Biology, University Medical Center Groningen, University of Groningen, The Netherlands
    Blood 119:377-87. 2012
    ..Finally, we performed genome-wide gene expression arrays and identified candidate target genes through which miR-125a may modulate HSPC fate...
  21. ncbi request reprint Long-term maintenance of human hematopoietic stem/progenitor cells by expression of BMI1
    Aleksandra Rizo
    Department of Cell Biology, Section Stem Cell Biology, University Medical Center, University of Groningen, Deusinglaan 1, Groningen, The Netherlands
    Blood 111:2621-30. 2008
    ..Thus, our data indicate that self-renewal of human hematopoietic stem cells is enhanced by BMI1, and we classify BMI1 as an intrinsic regulator of human stem/progenitor cell self-renewal...
  22. pmc Combining transcriptional profiling and genetic linkage analysis to uncover gene networks operating in hematopoietic stem cells and their progeny
    Alice Gerrits
    Department of Cell Biology, Section Stem Cell Biology, University Medical Center Groningen, University of Groningen, Antonius Deusinglaan 1, 9713 AV Groningen, The Netherlands
    Immunogenetics 60:411-22. 2008
    ..We review past studies of hematopoietic cells that utilized transcriptional profiling and/or genetic linkage analysis, and discuss several potential future applications of genetical genomics...
  23. doi request reprint Cytokine treatment improves parenchymal and vascular damage of salivary glands after irradiation
    Isabelle M A Lombaert
    Section of Radiation and Stress Cell Biology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    Clin Cancer Res 14:7741-50. 2008
    ..In this study, we investigate whether optimized mobilization of BMCs can further facilitate regeneration of radiation-damaged salivary glands...
  24. ncbi request reprint Epigenetic control of hematopoietic stem cell aging the case of Ezh2
    Gerald de Haan
    Department of Cell Biology, Section Stem Cell Biology, University Medical Center Groningen, University of Groningen, Antonius Deusinglaan 1, 9713 AV Groningen, The Netherlands
    Ann N Y Acad Sci 1106:233-9. 2007
    ..We provide evidence for the involvement of one of these Polycomb group genes, Ezh2, in aging of the hematopoietic stem cell system...
  25. doi request reprint Hematopoietic stem cell expansion: challenges and opportunities
    Marta A Walasek
    Department of Biology of Aging, Section Stem Cell Biology, European Research Institute for the Biology of Aging, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    Ann N Y Acad Sci 1266:138-50. 2012
    ..Here, we highlight early expansion attempts and review recent development in the extrinsic control of HSPC fate in vitro...
  26. pmc The Polycomb group gene Ezh2 prevents hematopoietic stem cell exhaustion
    Leonie M Kamminga
    Department of Cell Biology, Section Stem Cell Biology, University Medical Center Groningen, University of Groningen, The Netherlands
    Blood 107:2170-9. 2006
    ..Our data suggest that stabilization of the chromatin structure preserves HSC potential after replicative stress...
  27. ncbi request reprint Growth factor treatment prior to low-dose total body irradiation increases donor cell engraftment after bone marrow transplantation in mice
    Estelle J K Noach
    Department of Stem Cell Biology, University of Groningen, The Netherlands
    Blood 100:312-7. 2002
    ..We conclude that long-term donor cell engraftment can be strongly augmented by treatment of recipient mice prior to low-dose TBI with hematopoietic growth factors that act on primitive cells...
  28. doi request reprint Sca-1 is an early-response target of histone deacetylase inhibitors and marks hematopoietic cells with enhanced function
    Marta A Walasek
    Department of Biology of Aging, Section Stem Cell Biology, European Research Institute for the Biology of Aging, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    Exp Hematol 41:113-23.e2. 2013
    ..In conclusion, our results show that VPA modulates several genes involved in multiple signal transduction pathways, of which Sca-1 was shown to mark cells with increased self-renewal capacity in response to HDIs...
  29. pmc A statistical multiprobe model for analyzing cis and trans genes in genetical genomics experiments with short-oligonucleotide arrays
    Rudi Alberts
    Groningen Bioinformatics Centre GBiC, Groningen Biomolecular Sciences and Biotechnology Institute GBB, University of Groningen, 9751 NN, Haren, The Netherlands
    Genetics 171:1437-9. 2005
    ..It can also help in detecting alternative splicing, start, or termination...
  30. doi request reprint Aging of hematopoietic stem cells: Intrinsic changes or micro-environmental effects?
    Carolien M Woolthuis
    Department of Hematology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    Curr Opin Immunol 23:512-7. 2011
    ..Recently, changes in the clonal composition of the HSC compartment during aging have been put forward as a key factor. Here, we discuss these recent developments and speculate how they may be of clinical relevance...
  31. ncbi request reprint Selective expression of cholesterol metabolism genes in normal CD34+CD38- cells with a heterogeneous expression pattern in AML cells
    Susan D P W M Peeters
    Department of Hematology, University of Groningen and University Medical Center Groningen, Groningen, The Netherlands
    Exp Hematol 34:622-30. 2006
    ..To identify adenosine triphosphate-binding-cassette (ABC) transporters that are selectively expressed in normal and/or leukemic CD34+CD38- stem cells...
  32. doi request reprint Heterogeneity of young and aged murine hematopoietic stem cells revealed by quantitative clonal analysis using cellular barcoding
    Evgenia Verovskaya
    Laboratory of Ageing Biology and Stem Cells, European Research Institute for the Biology of Ageing, University Medical Centre Groningen, University of Groningen, Groningen, The Netherlands
    Blood 122:523-32. 2013
    ..Finally, we demonstrate that the pool of old HSCs is composed of multiple small clones, whereas the young HSC pool is dominated by fewer, but larger, clones. ..
  33. pmc Clonal analysis reveals multiple functional defects of aged murine hematopoietic stem cells
    Brad Dykstra
    Department of Cell Biology, European Research Institute on the Biology of Aging, University Medical Center Groningen, University of Groningen, 9700 RB Groningen, Netherlands
    J Exp Med 208:2691-703. 2011
    ....
  34. doi request reprint Hematopoietic stem cell quiescence: yet another role for p53
    Ronald van Os
    Department of Cell Biology, Section Stem Cell Biology, University Medical Center Groningen, 9713 AV Groningen, The Netherlands
    Cell Stem Cell 4:7-8. 2009
    ..Adding to this list, in this issue of Cell Stem Cell, Liu et al. (2009) show that p53 also plays a role in regulating hematopoietic stem cell quiescence...
  35. pmc A verification protocol for the probe sequences of Affymetrix genome arrays reveals high probe accuracy for studies in mouse, human and rat
    Rudi Alberts
    Groningen Bioinformatics Centre, Groningen Biomolecular Sciences and Biotechnology Institute, University of Groningen, 9751 NN Haren, The Netherlands
    BMC Bioinformatics 8:132. 2007
    ..To determine the accuracy of Affymetrix arrays, we developed an extensive verification protocol, for mouse arrays incorporating the NCBI RefSeq, NCBI UniGene Unique, NIA Mouse Gene Index, and UCSC mouse genome databases...
  36. ncbi request reprint Plant sterols cause macrothrombocytopenia in a mouse model of sitosterolemia
    Janine K Kruit
    Department of Pediatrics, Center for Liver, Digestive, and Metabolic Diseases, University Medical Centre Groningen, Groningen, The Netherlands
    J Biol Chem 283:6281-7. 2008
    ..Thus, accumulation of plant sterols is responsible for development of macrothrombocytopenia in sitosterolemia, and blocking intestinal plant sterol absorption provides an effective means of treatment...
  37. ncbi request reprint Modern genome-wide genetic approaches to reveal intrinsic properties of stem cells
    Gerald de Haan
    Department of Cell Biology, Stem Cell Biology, University Medical Center Groningen, Groningen, The Netherlands
    Curr Opin Hematol 13:249-53. 2006
    ..State-of-the art genome-wide tools are now becoming available to elucidate intrinsic properties of stem cells. Here, we review recent progress that has been made in this field...
  38. ncbi request reprint Hematopoietic stem cell aging and self-renewal
    Brad Dykstra
    Department of Cell Biology, Section Stem Cell Biology, University Medical Center Groningen, University of Groningen, Antonius Deusinglaan 1, Groningen, 9713 AV, The Netherlands
    Cell Tissue Res 331:91-101. 2008
    ..Further, whether the genetic dysregulation observed in old HSCs is a cause or an effect of cellular aging is unknown...
  39. doi request reprint Polycomb group proteins in hematopoietic stem cell aging and malignancies
    Karin Klauke
    Department of Cell Biology, Section of Stem Cell Biology, University Medical Center Groningen, University of Groningen, A Deusinglaan, Groningen, The Netherlands
    Int J Hematol 94:11-23. 2011
    ....
  40. ncbi request reprint Fibroblast growth factors as regulators of stem cell self-renewal and aging
    Joyce S G Yeoh
    Department of Cell Biology, Section Stem Cell Biology, University Medical Centre Groningen, Antonius Deusinglaan 1, 9713AV Groningen, The Netherlands
    Mech Ageing Dev 128:17-24. 2007
    ..These findings are useful and important to further our knowledge in stem cell biology and for therapeutic approaches...
  41. ncbi request reprint Signaling pathways in self-renewing hematopoietic and leukemic stem cells: do all stem cells need a niche?
    Aleksandra Rizo
    Department of Cell Biology, Section Stem Cell Biology, University Medical Centre Groningen, Groningen, The Netherlands
    Hum Mol Genet 15:R210-9. 2006
    ....
  42. pmc Rescue of salivary gland function after stem cell transplantation in irradiated glands
    Isabelle M A Lombaert
    Section Radiation and Stress Cell Biology, Department of Cell Biology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    PLoS ONE 3:e2063. 2008
    ..Our approach is the first proof for the potential use of stem cell transplantation to functionally rescue salivary gland deficiency...
  43. doi request reprint Undifferentiated embryonic cell transcription factor 1 regulates ESC chromatin organization and gene expression
    Susanne M Kooistra
    Department of Developmental Genetics, Groningen Biomolecular Sciences and Biotechnology Institute, University of Groningen, Haren, The Netherlands
    Stem Cells 28:1703-14. 2010
    ....
  44. ncbi request reprint Administration of low-dose cytarabine results in immediate S-phase arrest and subsequent activation of cell cycling in murine stem cells
    Kyrjon van Pelt
    Department of Hematology, Internal Medicine, University Hospital of Groningen, Groningen, The Netherlands
    Exp Hematol 33:226-31. 2005
    ..Hematopoietic stem cells (HSC) are considered to display a quiescent state with low turnover rate. We investigated the cell-cycle kinetics of HSC after a single dose of cytarabine (Ara-C)...
  45. ncbi request reprint Uncovering regulatory pathways that affect hematopoietic stem cell function using 'genetical genomics'
    Leonid Bystrykh
    Department of Stem Cell Biology, University of Groningen, Antonius Deusinglaan 1, 9713 AV Groningen, The Netherlands
    Nat Genet 37:225-32. 2005
    ..Our data are accessible through WebQTL, a web-based interface that allows custom genetic linkage analysis and identification of coregulated transcripts...
  46. ncbi request reprint Cellular memory and hematopoietic stem cell aging
    Leonie M Kamminga
    Department of Cell Biology, Section Stem Cell Biology, University Medical Center Groningen, University of Groningen, 9713 AV Groningen, The Netherlands
    Stem Cells 24:1143-9. 2006
    ..A model is suggested which describes how epigenetic regulation of gene transcription by modulation of the chromatin structure in stem cells can account for regulation of the aging program...
  47. ncbi request reprint Cerebellar heterokaryon formation increases with age and after irradiation
    Anita Wiersema
    Department of Cell Biology, Section Stem Cell Biology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    Stem Cell Res 1:150-4. 2007
    ..Our data suggest that age- and/or irradiation-induced dysfunctioning of Purkinje cells in the cerebellum is required for cell fusion...
  48. doi request reprint In vitro assays for cobblestone area-forming cells, LTC-IC, and CFU-C
    Ronald P van Os
    Department of Stem Cell Biology, University Medical Center Groningen, The Netherlands
    Methods Mol Biol 430:143-57. 2008
    ..Nevertheless, these in vitro assays provide an excellent method to screen for stem cell activity of a putative stem cell population or for screening the effect of a certain treatment on HSCs...
  49. doi request reprint Bone marrow transplantation in mice as a tool for studying the role of hematopoietic cells in metabolic and cardiovascular diseases
    Marcela Aparicio-Vergara
    Molecular Genetics, Medical Biology Section, Department of Pathology and Medical Biology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    Atherosclerosis 213:335-44. 2010
    ..Taken as a whole, this technology offers great advantages in efficiency and cost-effectiveness, and it is expected to continue to be a crucial technique in cardiovascular research work...
  50. ncbi request reprint Stem cell assays: something old, something new, something borrowed
    Ronald van Os
    Department of Stem Cell Biology, University of Groningen, The Netherlands
    Stem Cells 22:1181-90. 2004
    ..These assays should measure functionality of the putative stem cell population...
  51. ncbi request reprint Mobilized peripheral blood stem cells provide rapid reconstitution but impaired long-term engraftment in a mouse model
    J S G Yeoh
    Department of Cell Biology, Section Stem Cell Biology, University Medical Centre Groningen, Groningen, The Netherlands
    Bone Marrow Transplant 39:401-9. 2007
    ..Bone Marrow Transplantation (2007) 39, 401-409. doi:10.1038/sj.bmt.1705601; published online 12 February 2007...