Dick de Zeeuw

Summary

Affiliation: University Medical Center Groningen
Country: The Netherlands

Publications

  1. ncbi request reprint Early, but not late therapy with a vasopressin V1a-antagonist ameliorates the development of renal damage after 5/6 nephrectomy
    Willemijn A K M Windt
    Department of Clinical Pharmacology, Groningen Institute for Drug Evaluation GUIDE, University Medical Center Groningen, Antonius Deusinglaan 1 NL 9713 AV Groningen NL 9713, The Netherlands
    J Renin Angiotensin Aldosterone Syst 7:217-24. 2006
  2. pmc Trends in hyperlipidemia and hypertension management in type 2 diabetes patients from 1998-2004: a longitudinal observational study
    Jacoba P Greving
    Department of Clinical Pharmacology, University Medical Center Groningen, University of Groningen, The Netherlands
    Cardiovasc Diabetol 6:25. 2007
  3. ncbi request reprint Renal risk and renoprotection among ethnic groups with type 2 diabetic nephropathy: a post hoc analysis of RENAAL
    D de Zeeuw
    Department of Clinical Pharmacology, Groningen University Medical Center, Groningen, The Netherlands
    Kidney Int 69:1675-82. 2006
  4. doi request reprint Does the metabolic syndrome add to the diagnosis and treatment of cardiovascular disease?
    Dick de Zeeuw
    Department of Clinical Pharmacology, University Medical Center, Groningen, The Netherlands
    Nat Clin Pract Cardiovasc Med 5:S10-4. 2008
  5. doi request reprint Renal disease: a common and a silent killer
    Dick de Zeeuw
    Department of Clinical Pharmacology, University Medical Center, Groningen, The Netherlands
    Nat Clin Pract Cardiovasc Med 5:S27-35. 2008
  6. ncbi request reprint Albuminuria: a target for treatment of type 2 diabetic nephropathy
    Dick de Zeeuw
    Department of Clinical Pharmacology, University Medical Center Groningen, University of Groningen, Ant Deusinglaan 1, 9713 AV Groningen, The Netherlands
    Semin Nephrol 27:172-81. 2007
  7. doi request reprint Albuminuria: a great risk marker, but an underestimated target in diabetes
    Dick de Zeeuw
    Department of Clinical Pharmacology, University Medical Center Groningen, Sector F, PO Box 169, 9700 AD Groningen, The Netherlands
    Diabetes Care 31:S190-3. 2008
  8. doi request reprint Selective vitamin D receptor activation with paricalcitol for reduction of albuminuria in patients with type 2 diabetes (VITAL study): a randomised controlled trial
    Dick de Zeeuw
    University Medical Centre Groningen, University of Groningen, Groningen, Netherlands
    Lancet 376:1543-51. 2010
  9. ncbi request reprint Microalbuminuria as an early marker for cardiovascular disease
    Dick de Zeeuw
    Department of Clinical Pharmacology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    J Am Soc Nephrol 17:2100-5. 2006
  10. doi request reprint Unmet need in renal protection--do we need a more comprehensive approach?
    Dick de Zeeuw
    Department of Clinical Pharmacology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    Contrib Nephrol 171:157-60. 2011

Detail Information

Publications107 found, 100 shown here

  1. ncbi request reprint Early, but not late therapy with a vasopressin V1a-antagonist ameliorates the development of renal damage after 5/6 nephrectomy
    Willemijn A K M Windt
    Department of Clinical Pharmacology, Groningen Institute for Drug Evaluation GUIDE, University Medical Center Groningen, Antonius Deusinglaan 1 NL 9713 AV Groningen NL 9713, The Netherlands
    J Renin Angiotensin Aldosterone Syst 7:217-24. 2006
    ....
  2. pmc Trends in hyperlipidemia and hypertension management in type 2 diabetes patients from 1998-2004: a longitudinal observational study
    Jacoba P Greving
    Department of Clinical Pharmacology, University Medical Center Groningen, University of Groningen, The Netherlands
    Cardiovasc Diabetol 6:25. 2007
    ..The objective is to assess trends in risk factor treatment, and identify determinants for medication adjustments in patients with uncontrolled hypertension and/or hyperlipidemia...
  3. ncbi request reprint Renal risk and renoprotection among ethnic groups with type 2 diabetic nephropathy: a post hoc analysis of RENAAL
    D de Zeeuw
    Department of Clinical Pharmacology, Groningen University Medical Center, Groningen, The Netherlands
    Kidney Int 69:1675-82. 2006
    ..Since the RENAAL study was not powered to determine ethnic responses, these results underline the need for prospective trials where the aim is renal protection among different ethnic groups...
  4. doi request reprint Does the metabolic syndrome add to the diagnosis and treatment of cardiovascular disease?
    Dick de Zeeuw
    Department of Clinical Pharmacology, University Medical Center, Groningen, The Netherlands
    Nat Clin Pract Cardiovasc Med 5:S10-4. 2008
    ..The syndrome has, however, served and continues to serve a useful purpose in raising awareness of the metabolic consequences of obesity, and as a spur for research into metabolic risk factor interactions...
  5. doi request reprint Renal disease: a common and a silent killer
    Dick de Zeeuw
    Department of Clinical Pharmacology, University Medical Center, Groningen, The Netherlands
    Nat Clin Pract Cardiovasc Med 5:S27-35. 2008
    ....
  6. ncbi request reprint Albuminuria: a target for treatment of type 2 diabetic nephropathy
    Dick de Zeeuw
    Department of Clinical Pharmacology, University Medical Center Groningen, University of Groningen, Ant Deusinglaan 1, 9713 AV Groningen, The Netherlands
    Semin Nephrol 27:172-81. 2007
    ....
  7. doi request reprint Albuminuria: a great risk marker, but an underestimated target in diabetes
    Dick de Zeeuw
    Department of Clinical Pharmacology, University Medical Center Groningen, Sector F, PO Box 169, 9700 AD Groningen, The Netherlands
    Diabetes Care 31:S190-3. 2008
  8. doi request reprint Selective vitamin D receptor activation with paricalcitol for reduction of albuminuria in patients with type 2 diabetes (VITAL study): a randomised controlled trial
    Dick de Zeeuw
    University Medical Centre Groningen, University of Groningen, Groningen, Netherlands
    Lancet 376:1543-51. 2010
    ..We aimed to assess whether paricalcitol could be used to reduce albuminuria in patients with diabetic nephropathy...
  9. ncbi request reprint Microalbuminuria as an early marker for cardiovascular disease
    Dick de Zeeuw
    Department of Clinical Pharmacology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    J Am Soc Nephrol 17:2100-5. 2006
    ..In conclusion, albuminuria seems to be a sensitive marker very early in life for the susceptibility of an individual to CV disease. It therefore may be an ideal target for early primary prevention using CV-protective therapy regimens...
  10. doi request reprint Unmet need in renal protection--do we need a more comprehensive approach?
    Dick de Zeeuw
    Department of Clinical Pharmacology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    Contrib Nephrol 171:157-60. 2011
    ..Recent trials testing the effect of vitamin D receptor activators and the effect of statins indicate that drugs in these classes may become valuable extra tools (in addition to ACEi or ARB) to tackle the unmet need in renal protection...
  11. ncbi request reprint Albuminuria, a therapeutic target for cardiovascular protection in type 2 diabetic patients with nephropathy
    Dick de Zeeuw
    Department of Clinical Pharmacology, Groningen University Medical Center, Ant Deusinglaan 1, 9713 AV Groningen, Netherlands
    Circulation 110:921-7. 2004
    ..Albuminuria can be reduced with drugs that block the renin-angiotensin system (RAS). We questioned whether the short-term drug-induced change in albuminuria would predict the long-term cardioprotective efficacy of RAS intervention...
  12. doi request reprint An acute fall in estimated glomerular filtration rate during treatment with losartan predicts a slower decrease in long-term renal function
    Frank A Holtkamp
    Department of Clinical Pharmacology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    Kidney Int 80:282-7. 2011
    ..Hence, interpretation of trial results relying on slope-based GFR outcomes should separate the initial drug-induced GFR change from the subsequent long-term effect on GFR...
  13. doi request reprint Gender differences in predictors of the decline of renal function in the general population
    Nynke Halbesma
    Division of Nephrology, Department of Medicine, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    Kidney Int 74:505-12. 2008
    ..These studies show that there are gender differences in the standard predictors of the decline in renal function...
  14. ncbi request reprint Altered myogenic constriction and endothelium-derived hyperpolarizing factor-mediated relaxation in small mesenteric arteries of hypertensive subtotally nephrectomized rats
    Simone Vettoretti
    Department of Clinical Pharmacology, University Medical Center Groningen and Groningen Institute for Drug Exploration GUIDE, University of Groningen, The Netherlands
    J Hypertens 24:2215-23. 2006
    ..We investigated whether myogenic response and EDHF are altered in subtotally nephrectomized (sNX) rats and whether these changes are modifiable by chronic treatment with angiotensin-converting enzyme (ACE) inhibitor...
  15. ncbi request reprint Does angiotensin (1-7) contribute to the anti-proteinuric effect of ACE-inhibitors
    Els A Van der Wouden
    Department of Clinical Pharmocology, Division of Nephrology, Groningen University Institute for Drug Exploration GUIDE, University Medical Center Groningen, Groningen, The Netherlands
    J Renin Angiotensin Aldosterone Syst 6:96-101. 2005
    ..We conclude that systemic Ang (1-7) plays no major role in the anti-proteinuric and BPlowering effects of ACE-I in this rat model of adriamycin-induced nephrosis...
  16. ncbi request reprint Renal targeting of captopril using captopril-lysozyme conjugate enhances its antiproteinuric effect in adriamycin-induced nephrosis
    Willemijn A K M Windt
    Department of Clinical Pharmacology, Groningen University, Antonius Deusinglaan 1, 9713 AV Groningen, The Netherlands
    J Renin Angiotensin Aldosterone Syst 5:197-202. 2004
    ..We compared the antiproteinuric efficacy of captopril to that of the captopril-lysozyme conjugate in adriamycin-induced proteinuric rats fed with a high-sodium diet...
  17. ncbi request reprint Involvement of renal ACE activity in proteinuria-associated renal damage in untreated and treated adriamycin nephrotic rats
    Hendrik Bos
    Department of Nephrology, Groningen University, Groningen, The Netherlands
    J Renin Angiotensin Aldosterone Syst 4:106-12. 2003
    ..Renal ACE activity is a consistent marker of individual differences in proteinuria-associated renal damage: further studies are needed to investigate a possible pathogenetic role in renal damage...
  18. ncbi request reprint Renal function and risk for cardiovascular events in type 2 diabetic patients with hypertension: the RENAAL and LIFE studies
    Wouter B A Eijkelkamp
    Department of Clinical Pharmacology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    J Hypertens 25:871-6. 2007
    ....
  19. doi request reprint Renal endothelial function and blood flow predict the individual susceptibility to adriamycin-induced renal damage
    Peter Ochodnicky
    Department of Clinical Pharmacology, University Medical Center Groningen UMCG and Graduate School for Drug Exploration GUIDE, University of Groningen, The Netherlands
    Nephrol Dial Transplant 24:413-20. 2009
    ..Here we hypothesized that individual differences in endothelial function in vitro and renal perfusion in vivo predict the severity of renal damage in a model of adriamycin-induced nephropathy...
  20. doi request reprint Moderation of dietary sodium potentiates the renal and cardiovascular protective effects of angiotensin receptor blockers
    Hiddo J Lambers Heerspink
    Department of Clinical Pharmacology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    Kidney Int 82:330-7. 2012
    ..This underscores the avoidance of excessive sodium intake, particularly in type 2 diabetic patients receiving ARB therapy...
  21. ncbi request reprint A central body fat distribution is related to renal function impairment, even in lean subjects
    Sara Joan Pinto-Sietsma
    Division of Nephrology, Department of Internal Medicine, University Hospital Groningen, Groningen, The Netherlands
    Am J Kidney Dis 41:733-41. 2003
    ..Whether this depends on fat distribution is not known. We hypothesize that in addition to overweight, fat distribution may be associated with renal function abnormalities...
  22. ncbi request reprint C-reactive protein modifies the relationship between blood pressure and microalbuminuria
    Erik M Stuveling
    Department of Medicine, University Medical Center, Groningen, The Netherlands
    Hypertension 43:791-6. 2004
    ..0004). No significant interactions between other risk factors and CRP with respect to the risk of microalbuminuria were encountered. Thus, CRP modifies the relation between blood pressure and microalbuminuria...
  23. ncbi request reprint Albuminuria is a target for renoprotective therapy independent from blood pressure in patients with type 2 diabetic nephropathy: post hoc analysis from the Reduction of Endpoints in NIDDM with the Angiotensin II Antagonist Losartan (RENAAL) trial
    Wouter B A Eijkelkamp
    Department of Clinical Pharmacology, University Medical Center Groningen, University of Groningen, Groningen, Netherlands
    J Am Soc Nephrol 18:1540-6. 2007
    ..Antihypertensive treatment that is aimed at improving renal outcomes in patients with diabetic nephropathy may therefore require a dual strategy, targeting both SBP and albuminuria reduction...
  24. ncbi request reprint Effects of fosinopril and pravastatin on cardiovascular events in subjects with microalbuminuria
    Folkert W Asselbergs
    Department of Clinical Pharmacology, University of Groningen, Groningen, The Netherlands
    Circulation 110:2809-16. 2004
    ..We assessed whether therapeutic intervention aimed at lowering urinary albumin excretion would reduce cardiovascular events in microalbuminuric subjects (15 to 300 mg/24 hours)...
  25. ncbi request reprint The association between atherosclerotic risk factors and renal function in the general population
    Jacobien C Verhave
    Department of Medicine, Division of Nephrology, Groningen University Medical Center, Groningen, The Netherlands
    Kidney Int 67:1967-73. 2005
    ..Generalized atherosclerosis is increasingly recognized as an important cause of end-stage renal disease (ESRD). We questioned to what extent atherosclerotic risk factors determine renal function in the general population...
  26. doi request reprint Effect of a reduction in uric acid on renal outcomes during losartan treatment: a post hoc analysis of the reduction of endpoints in non-insulin-dependent diabetes mellitus with the Angiotensin II Antagonist Losartan Trial
    Yan Miao
    Department of Clinical Pharmacology, University Medical Centre Groningen, Antonius Deusinglaan 1, 9713 AV, Groningen, The Netherlands
    Hypertension 58:2-7. 2011
    ..These findings support the view that SUA may be a modifiable risk factor for renal disease...
  27. doi request reprint Albuminuria and blood pressure, independent targets for cardioprotective therapy in patients with diabetes and nephropathy: a post hoc analysis of the combined RENAAL and IDNT trials
    Frank A Holtkamp
    Department of Clinical Pharmacology, University Medical Center Groningen, University of Groningen, Antonius Deusinglaan 1, Groningen, The Netherlands
    Eur Heart J 32:1493-9. 2011
    ....
  28. ncbi request reprint Renal damage after myocardial infarction is prevented by renin-angiotensin-aldosterone-system intervention
    Willemijn A K M Windt
    Department of Clinical Pharmacology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    J Am Soc Nephrol 17:3059-66. 2006
    ..VPI treatment seemed to provide no additional renoprotection compared with sole ACEi after 6 wk of treatment in this model, despite a more pronounced ACE-inhibiting effect of VPI...
  29. ncbi request reprint Therapeutic resistance to angiotensin converting enzyme (ACE) inhibition is related to pharmacodynamic and -kinetic factors in 5/6 nephrectomized rats
    Willemijn A K M Windt
    Department of Clinical Pharmacology, Groningen Institute for Drug Evaluation, University Medical Center Groningen, University of Groningen, The Netherlands
    Eur J Pharmacol 580:231-40. 2008
    ..32, P=0.003). In conclusion, both pharmacodynamic and -kinetic factors account for the non-response to lisinopril. Whether these can be overcome simply by increasing drug dosage in non-responders should be investigated...
  30. ncbi request reprint Endothelial dysfunction and infarct-size relate to impaired EDHF response in rat experimental chronic heart failure
    Simone Gschwend
    Department of Clinical Pharmacology, University of Groningen, A Deusinglaan 1, 9713 AV, Groningen, The Netherlands
    Eur J Heart Fail 5:147-54. 2003
    ..Inconsistent results have been obtained concerning the role of endothelial dilative mediators nitric oxide (NO) and endothelium-derived hyperpolarizing factor (EDHF)...
  31. doi request reprint Identifying targets to improve treatment in type 2 diabetes; the Groningen Initiative to aNalyse Type 2 diabetes Treatment (GIANTT) observational study
    Jaco Voorham
    Department of Clinical Pharmacology, Department of Epidemiology, University Medical Center Groningen, University of Groningen, The Netherlands
    Pharmacoepidemiol Drug Saf 19:1078-86. 2010
    ..Assessment of quality of cardiometabolic risk management in diabetes in primary care...
  32. doi request reprint An initial reduction in serum uric acid during angiotensin receptor blocker treatment is associated with cardiovascular protection: a post-hoc analysis of the RENAAL and IDNT trials
    Paul A Smink
    Department of Clinical Pharmacology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    J Hypertens 30:1022-8. 2012
    ..Treatment with the angiotensin receptor blocker (ARB) losartan lowers SUA in contrast to other ARBs. Whether reductions in SUA during ARB therapy are associated with cardiovascular protection is unclear. We aimed to investigate this...
  33. ncbi request reprint Urinary albumin excretion as a predictor of the development of hypertension in the general population
    Auke H Brantsma
    Division of Nephrology, Department of Medicine, University Medical Center Groningen, PO Box 30 001, Groningen, 9700 RB The Netherlands
    J Am Soc Nephrol 17:331-5. 2006
    ..In conclusion, these findings support the hypothesis that mild renal damage may precede the development of hypertension...
  34. ncbi request reprint Endothelial function predicts the development of renal damage after combined nephrectomy and myocardial infarction
    Peter Ochodnicky
    Department of Clinical Pharmacology, University Medical Centre Groningen, The Netherlands
    J Am Soc Nephrol 17:S49-52. 2006
    ..Further exploration of the underlying mechanisms may lead to discovery of preventive renoprotective therapies...
  35. ncbi request reprint What predicts progression and regression of urinary albumin excretion in the nondiabetic population?
    Auke H Brantsma
    Division of Nephrology, Department of Medicine, University Medical Center Groningen, PO Box 30 001, 9700 RB Groningen, The Netherlands
    J Am Soc Nephrol 18:637-45. 2007
    ....
  36. doi request reprint Renal and cardio-protective effects of direct renin inhibition: a systematic literature review
    Hiddo J Lambers Heerspink
    Department of Clinical Pharmacology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    J Hypertens 27:2321-31. 2009
    ..This systematic review aims to delineate the effects of DRIs on surrogate markers of renal and cardiovascular function...
  37. pmc Comparison of different measures of urinary protein excretion for prediction of renal events
    Hiddo J Lambers Heerspink
    Department of Clinical Pharmacology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    J Am Soc Nephrol 21:1355-60. 2010
    ..In conclusion, measurement of the albumin:creatinine ratio in a first-morning void is the superior method to predict renal events in patients with type 2 diabetes and nephropathy...
  38. ncbi request reprint Uptake of angiotensin II receptor blockers in the treatment of hypertension
    Jacoba P Greving
    Department of Clinical Pharmacology, University Medical Center Groningen, PO Box 196, 9700, AD, Groningen, The Netherlands
    Eur J Clin Pharmacol 61:461-6. 2005
    ..To examine trends in prescribing of angiotensin II receptor blockers (ARBs) as initial and second-line treatment of hypertension...
  39. doi request reprint Is albuminuria screening and treatment optimal in patients with type 2 diabetes in primary care? Observational data of the GIANTT cohort
    Merel E Hellemons
    Department of Clinical Pharmacology, University Medical Center Groningen, Groningen, The Netherlands
    Nephrol Dial Transplant 28:706-15. 2013
    ..We evaluated guideline adherence and factors associated with albuminuria screening and treatment in T2DM patients in primary care...
  40. doi request reprint Association between performance measures and glycemic control among patients with diabetes in a community-wide primary care cohort
    Grigory Sidorenkov
    Department of Clinical Pharmacology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands
    Med Care 51:172-9. 2013
    ..Performance measures are used for assessing quality of care. Higher performance shown by these measures is expected to reflect better care, but little is known whether they predict better patient outcomes...
  41. doi request reprint Myocardial infarction does not further impair renal damage in 5/6 nephrectomized rats
    Willemijn A K M Windt
    Department of Clinical Pharmacology, University Medical Center Groningen, PO Box 196, NL 9700 AD, Groningen, The Netherlands
    Nephrol Dial Transplant 23:3103-10. 2008
    ..The effects of an MI on pre-existing severe renal function loss and the effects of RAAS intervention interrupting this hypothesized cardiorenal interaction are however unknown and clinically even more relevant...
  42. ncbi request reprint Beneficial effects of add-on hydrochlorothiazide in rats with myocardial infarction optimally treated with quinapril
    Bart Westendorp
    Department of Clinical Pharmacology, University of Groningen, The Netherlands
    Eur J Heart Fail 7:1085-94. 2005
    ..Therefore, we investigated whether hydrochlorothiazide (HCTZ) or dietary sodium restriction further improves survival in ACEi-treated rats with MI...
  43. ncbi request reprint Effects of anti-proteinuric therapy with angiotensin-converting-enzyme inhibition on renal protein catabolism in the adriamycin-induced nephrotic rat
    Marijke Haas
    Department of Clinical Pharmacology, Groningen University Institute for Drug Exploration, University of Groningen, P O Box 196, NL 9700 AD Groningen, The Netherlands
    Clin Sci (Lond) 105:51-7. 2003
    ..Taken together, the data suggest that proteinuria is toxic for the proximal tubular cells and that ACE inhibition protects the remaining functional tubular cells directly against destruction through decreasing hypercatabolism...
  44. ncbi request reprint Microalbuminuria and endothelial dysfunction: emerging targets for primary prevention of end-organ damage
    Peter Ochodnicky
    Department of Clinical Pharmacology, University Medical Center Groningen and Groningen Institute for Drug Exploration GUIDE, University of Groningen, The Netherlands
    J Cardiovasc Pharmacol 47:S151-62; discussion S172-6. 2006
    ..In near future, dietary components improving nitric oxide bioavailability, such as cocoa-derived flavanols may play important role in these preventive strategies...
  45. ncbi request reprint Individual titration for maximal blockade of the renin-angiotensin system in proteinuric patients: a feasible strategy?
    Liffert Vogt
    Division Nephrology, Department of Medicine, Groningen University Medical Center, Groningen, The Netherlands
    J Am Soc Nephrol 16:S53-7. 2005
    ..To further improve renoprotective treatment strategies, it is important to explore other modes of antiproteinuric intervention in patients with residual proteinuria during RAS blockade...
  46. ncbi request reprint Role of proteinuria in the regulation of renal renin-angiotensin system components in unilateral proteinuric rats
    Leo E Deelman
    Department of Clinical Pharmacology, University of Groningen, Groningen, 9713AV, The Netherlands
    J Renin Angiotensin Aldosterone Syst 4:38-42. 2003
    ..In conclusion, renal expression of ACE, AT2-R, and AT1-R mRNA is not mediated by protein leakage. Local intrarenal protein leakage did influence renal TGF-beta mRNA expression...
  47. pmc Impact of the preintervention rate of renal function decline on outcome of renoprotective intervention
    A Titia Lely
    Department of Internal Medicine, Division of Nephrology, University Medical Center Groningen, University of Groningen, Hanzeplein 1, 9713 GZ Groningen, Netherlands
    Clin J Am Soc Nephrol 3:54-60. 2008
    ..There are no data showing that this provides groups with similar baseline rates of renal function loss. Accordingly, the impact of preintervention rate of renal function loss (slope) on outcome of studies has not been established...
  48. ncbi request reprint Myocardial infarction enhances progressive renal damage in an experimental model for cardio-renal interaction
    Richard P E van Dokkum
    Department of Clinical Pharmacology, University Medical Center Groningen, Antonius Deusinglaan 1, NL 9713 AV Groningen, The Netherlands
    J Am Soc Nephrol 15:3103-10. 2004
    ..Finding the underlying mechanism will enable improved protection for both kidneys and heart...
  49. ncbi request reprint Endothelial dilatory function predicts individual susceptibility to renal damage in the 5/6 nephrectomized rat
    Simone Gschwend
    Department of Clinical Pharmacology, University of Groningen, A Deusinglaan 1, 9713 AV Groningen, The Netherlands
    J Am Soc Nephrol 13:2909-15. 2002
    ..This study demonstrates for the first time that individual renal endothelial dilatory function of the healthy rat predicts susceptibility to renal damage after 5/6 Nx, which seems to depend on individual endothelial NO and PG activity...
  50. ncbi request reprint The role of angiotensin(1-7) in renal vasculature of the rat
    Els A Van der Wouden
    Department of Clinical Pharmacology, Groningen University Institute for Drug Exploration, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    J Hypertens 24:1971-8. 2006
    ..Angiotensin(1-7) is an active component of the renin-angiotensin-aldosterone system. Its exact role in renal vascular function is unclear. We therefore studied the effects of angiotensin(1-7) on the renal vasculature in vitro and in vivo...
  51. pmc Differential effects of comorbidity on antihypertensive and glucose-regulating treatment in diabetes mellitus--a cohort study
    Jaco Voorham
    Department of Clinical Pharmacology, Faculty of Medical Science, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    PLoS ONE 7:e38707. 2012
    ..We hypothesized that these effects differ according to expected priority of the conditions...
  52. doi request reprint Effect of the urotensin receptor antagonist palosuran in hypertensive patients with type 2 diabetic nephropathy
    Liffert Vogt
    University Medical Center Groningen, University of Groningen, Hanzeplein 1, 9713 GZ Groningen, The Netherlands
    Hypertension 55:1206-9. 2010
    ..These results question whether urotensin receptor antagonism represents a new treatment strategy in this high-risk patient population...
  53. pmc Screening for albuminuria identifies individuals at increased renal risk
    Marije van der Velde
    Division of Nephrology, Department of Internal Medicine, University Medical Center Groningen, Groningen, The Netherlands
    J Am Soc Nephrol 20:852-62. 2009
    ..Screening for albuminuria identifies patients at increased risk for progressive renal disease, 40 to 50% of whom were previously undiagnosed or untreated...
  54. pmc First morning voids are more reliable than spot urine samples to assess microalbuminuria
    Elsbeth C Witte
    Department of Nephrology, University Medical Center Groningen, University of Groningen, Antonius Deusinglaan 1, 9713 AV Groningen, The Netherlands
    J Am Soc Nephrol 20:436-43. 2009
    ..In conclusion, measurement of albuminuria in a first morning void, preferably as the ACR, is more reliable than a spot urine sample to diagnose and monitor microalbuminuria...
  55. doi request reprint Albuminuria assessed from first-morning-void urine samples versus 24-hour urine collections as a predictor of cardiovascular morbidity and mortality
    Hiddo J Lambers Heerspink
    Department of Clinical Pharmacology, University Medical Center Groningen, P O Box 30 001, 9700 RB Groningen, The Netherlands
    Am J Epidemiol 168:897-905. 2008
    ..To predict cardiovascular morbidity and all-cause mortality, measuring ACR in a first-morning-void urine sample is a good alternative to measuring 24-hour UAE...
  56. pmc Effects of dietary sodium and hydrochlorothiazide on the antiproteinuric efficacy of losartan
    Liffert Vogt
    Department of Internal Medicine, Division of Nephrology, University Medical Center Groningen, University of Groningen, Groningen, Netherlands
    J Am Soc Nephrol 19:999-1007. 2008
    ..Combining these interventions in sodium status is an effective method to maximize the antiproteinuric efficacy of RAAS blockade...
  57. ncbi request reprint Albuminuria: what can we expect from the determination of nonimmunoreactive albumin?
    Stephan J L Bakker
    Department of Internal Medicine, University Medical Center Groningen, Hanzeplein 1, 9713 GZ Groningen, The Netherlands
    Curr Hypertens Rep 11:111-7. 2009
    ....
  58. ncbi request reprint Renoprotective effects of VPI versus ACEI in normotensive nephrotic rats on different sodium intakes
    Gozewijn D Laverman
    Department of Medicine, Groningen University Institute of Drug Exploration GUIDE, University of Groningen, The Netherlands
    Kidney Int 63:64-71. 2003
    ..Therefore, in contrast with ACEI, VPI may be effective during high sodium intake...
  59. ncbi request reprint Urinary albumin excretion and its relation with C-reactive protein and the metabolic syndrome in the prediction of type 2 diabetes
    Auke H Brantsma
    Division of Nephrology, Department of Medicine, University Medical Center Groningen, P O Box 30, 001, 9700 RB, Groningen, Netherlands
    Diabetes Care 28:2525-30. 2005
    ..To investigate urinary albumin excretion (UAE) and its relation with C-reactive protein (CRP) and the metabolic syndrome in the prediction of the development of type 2 diabetes...
  60. ncbi request reprint The abnormal renal vasodilator response to D1-like receptor stimulation in conscious SHR can be normalized by AT1 blockade
    P A Marcel de Vries
    Departments of Clinical Pharmacology, Groningen University Institute for Drug Exploration GUIDE, State University, Groningen, The Netherlands
    J Cardiovasc Pharmacol 44:571-6. 2004
    ....
  61. ncbi request reprint Do severe systemic sequelae of proteinuria modulate the antiproteinuric response to chronic ACE inhibition?
    Hendrik Bos
    Department of Clinical Pharmacology, Faculty of Medical Sciences and Groningen University Institute of Drug Exploration GUIDE, University of Groningen, The Netherlands
    Nephrol Dial Transplant 17:793-7. 2002
    ..In the present study we therefore investigated whether the severity of systemic nephrosis, estimated from plasma cholesterol, predicts residual proteinuria during ACE inhibition...
  62. doi request reprint N-terminal pro-B-type natriuretic peptide is an independent predictor of cardiovascular morbidity and mortality in the general population
    Gerard C M Linssen
    Department of Cardiology, Thoraxcenter, University Medical Center Groningen, Hanzeplein 1, PO Box 30 001, 9700 RB Groningen, The Netherlands
    Eur Heart J 31:120-7. 2010
    ..However, their prognostic value in the general population is less well established. The purpose of our study was to investigate the prognostic properties of NT-proBNP for death and cardiovascular (CV) events in the general population...
  63. ncbi request reprint Dual renin-angiotensin system blockade at optimal doses for proteinuria
    Gozewijn D Laverman
    Division of Nephrology, Faculty of Medical Sciences, University of Groningen, Hanzeplein 1, 9713 GZ Groningen, The Netherlands
    Kidney Int 62:1020-5. 2002
    ..The antiproteinuric effect of combining the angiotensin-converting enzyme (ACE) inhibitor lisinopril and the angiotensin II (Ang II) antagonist losartan was compared to that of the optimal antiproteinuric doses of monotherapy...
  64. ncbi request reprint Dietary sodium restriction specifically potentiates left ventricular ACE inhibition by zofenopril, and is associated with attenuated hypertrophic response in rats with myocardial infarction
    Bart Westendorp
    Department of Clinical Pharmacology, University of Groningen, Groningen, The Netherlands
    J Renin Angiotensin Aldosterone Syst 5:27-32. 2004
    ..In line with the latter, the aim of the present study was to explore whether dietary sodium restriction enhances the efficacy of ACE-I after MI...
  65. ncbi request reprint Proteinuria, a target for renoprotection in patients with type 2 diabetic nephropathy: lessons from RENAAL
    Dick de Zeeuw
    Department of Clinical Pharmacology, University Medical Center Groningen, Groningen, The Netherlands
    Kidney Int 65:2309-20. 2004
    ....
  66. ncbi request reprint Macroalbuminuria is a better risk marker than low estimated GFR to identify individuals at risk for accelerated GFR loss in population screening
    Nynke Halbesma
    Division of Nephrology, Department of Medicine, University Medical Center Groningen, P O Box 30 001, 9700 RB Groningen, The Netherlands
    J Am Soc Nephrol 17:2582-90. 2006
    ..However, macroalbuminuria is a better risk marker than low eGFR or erythrocyturia to identify in population screening of individuals who are at risk for accelerated GFR loss...
  67. pmc Renal targeting of captopril selectively enhances the intrarenal over the systemic effects of ACE inhibition in rats
    R Folgert G Haverdings
    Department of Pharmacokinetics and Drug Delivery, University of Groningen, The Netherlands
    Br J Pharmacol 136:1107-16. 2002
    ..5 These data demonstrate that intravenous administration of a captopril-lysozyme conjugate leads to more selective renal ACE inhibition and enhanced renal effects as well as less systemic effects compared to captopril itself...
  68. doi request reprint Cardiovascular and renal outcome in subjects with K/DOQI stage 1-3 chronic kidney disease: the importance of urinary albumin excretion
    Auke H Brantsma
    Division of Nephrology, Department of Internal Medicine, University Medical Center Groningen, Groningen, The Netherlands
    Nephrol Dial Transplant 23:3851-8. 2008
    ..In this study we evaluated cardiovascular and renal outcome in subjects with stage 1 and 2 CKD. For comparison, we also studied these outcomes in stage 3 CKD...
  69. ncbi request reprint Apparent loss of urinary albumin during long-term frozen storage: HPLC vs immunonephelometry
    Jacoline W Brinkman
    Department of Clinical Pharmacology, University Medical Center Groningen and University of Groningen, Groningen, The Netherlands
    Clin Chem 53:1520-6. 2007
    ..We investigated whether this technique is affected by sample temperature, particularly freezing...
  70. ncbi request reprint Low sodium diet inhibits the local counter-regulator effect of angiotensin-(1-7) on angiotensin II
    Anton J M Roks
    Department of Clinical Pharmacology, Groningen University Institute for Drug Exploration GUIDE, University of Groningen, Groningen, The Netherlands
    J Hypertens 22:2355-61. 2004
    ..The role of angiotensin receptor subtypes and the endothelium was assessed...
  71. ncbi request reprint Low sodium modifies the vascular effects of angiotensin-converting enzyme inhibitor therapy in healthy rats
    Menno J A Kocks
    Department of Clinical Pharmacology, University of Groningen, Antonius Deusinglaan 1, 9713 AV Groningen, The Netherlands
    J Pharmacol Exp Ther 310:1183-9. 2004
    ..These findings provide a rationale for further studies addressing the mechanism-of-actions of our therapies to find additional strategies to improve therapy response...
  72. ncbi request reprint Addition of AT1 blocker fails to overcome resistance to ACE inhibition in adriamycin nephrosis
    Hendrik Bos
    Department of Clinical Pharmacology, Faculty of Medical Sciences and Groningen University Institute of Drug Exploration GUIDE, University of Groningen, Groningen, The Netherlands
    Kidney Int 61:473-80. 2002
    ..We studied whether co-treatment with an angiotensin II subtype 1 (AT1) receptor antagonist (AII-A) improves the individual antiproteinuric response of maximal ACE inhibition in established adriamycin nephrosis...
  73. ncbi request reprint Update on microalbuminuria as a biomarker in renal and cardiovascular disease
    Hiddo J Lambers Heerspink
    Department of Clinical Pharmacology, The Netherlands bDepartment of Internal Medicine, The Netherlands
    Curr Opin Nephrol Hypertens 15:631-6. 2006
    ..To discuss recently published papers on the potential use of albuminuria as a predictor of cardiovascular and renal disease...
  74. ncbi request reprint Renoprotective therapy: is it blood pressure or albuminuria that matters?
    Paul E de Jong
    Division of Nephrology, Department of Medicine, University Medical Center Groningen, 9713 GZ Groningen, Netherlands
    Lancet 365:913-4. 2005
  75. ncbi request reprint The angiotensin II receptor antagonist telmisartan reduces urinary albumin excretion in patients with isolated systolic hypertension: results of a randomized, double-blind, placebo-controlled trial
    Liffert Vogt
    Department of Clinical Pharmacology and Internal Medicine, Division of Nephrology, University Medical Center, University of Groningen, The Netherlands
    J Hypertens 23:2055-61. 2005
    ....
  76. ncbi request reprint Best practice for hypertensive patients with kidney disease
    Dick de Zeeuw
    Department of Clinical Pharmacology, University of Groningen, Ant Deusingglaan 1, 9713 AV Groningen, The Netherlands
    Hosp Med 64:96-100. 2003
    ..The US National Kidney Foundation guidelines recommend that angiotensin-converting enzyme inhibitors and angiotensin type receptor antagonists are first choice therapy for these patients...
  77. ncbi request reprint Renoprotection: a matter of blood pressure reduction or agent-characteristics?
    Liffert Vogt
    Department of Internal Medicine, Division of Nephrology, University Hospital, Groningen, The Netherlands
    J Am Soc Nephrol 13:S202-7. 2002
    ..Future studies should further explore the renoprotective benefit of non-antihypertensive intervention measures, alone and in combination with antihypertensive strategies...
  78. ncbi request reprint Urinary albumin excretion predicts cardiovascular and noncardiovascular mortality in general population
    Hans L Hillege
    Trial Coordination Center, Department of Cardiology, University Hospital of Groningen, Groningen, The Netherlands
    Circulation 106:1777-82. 2002
    ..Therefore, we examined the relationship between urinary albumin excretion and all-cause mortality and mortality caused by cardiovascular (CV) disease and non-CV disease in the general population...
  79. ncbi request reprint Targeting of doxorubicin to the urinary bladder of the rat shows increased cytotoxicity in the bladder urine combined with an absence of renal toxicity
    Marijke Haas
    University of Groningen, The Netherlands
    J Drug Target 10:81-9. 2002
    ..A release of cytotoxic doxorubicin in the urinary bladder can be achieved by acidification of the urine. This technology, after further optimization, may provide an interesting tool for the treatment of bladder carcinoma...
  80. ncbi request reprint Does comorbidity explain trends in prescribing of newer antihypertensive agents?
    Jacoba P Greving
    Department of Clinical Pharmacology, University of Groningen, The Netherlands
    J Hypertens 22:2209-15. 2004
    ..The association between comorbidity and trends in prescribing of angiotensin-converting enzyme inhibitors (ACE-I) and angiotensin II receptor blockers (ARBs) was examined for the period 1996-2000...
  81. ncbi request reprint Cardiovascular risk factors are differently associated with urinary albumin excretion in men and women
    Jacobien C Verhave
    Division of Nephrology, Department of Medicine, University Medical Center Groningen, Groningen University Institute of Drug Exploration GUIDE, Hanzeplein 1, 9713 GZ Groningen, The Netherlands
    J Am Soc Nephrol 14:1330-5. 2003
    ..It is concluded that gender differences exist in the association between cardiovascular risk factors and UAE. This is consistent with a larger vascular susceptibility to these risk factors in men as compared with women...
  82. ncbi request reprint Drawbacks of the use of indirect estimates of renal function to evaluate the effect of risk factors on renal function
    Jacobien C Verhave
    Division of Nephrology, Department of Medicine, University Medical Center, Groningen, The Netherlands
    J Am Soc Nephrol 15:1316-22. 2004
    ..For studying the relation of risk factors and renal function in large population studies, indirect estimates of renal function should be used with caution...
  83. ncbi request reprint High dietary sodium blunts affects of angiotensin-converting enzyme inhibition on vascular angiotensin I-to-angiotensin II conversion in rats
    Menno J A Kocks
    Department of Internal Medicine, Division of Nephrology, University of Groningen, The Netherlands
    J Cardiovasc Pharmacol 42:601-6. 2003
    ..Thus, HS blunts the ACEi-induced reduction of functional vascular Ang I conversion compared with LS. Whether the blunted functional vascular conversion is causally related to the blunted blood pressure response remains to be elucidated...
  84. ncbi request reprint Microalbuminuria and C-reactive protein: similar messengers of cardiovascular risk?
    Stephan J L Bakker
    Department of Internal Medicine, University Medical Center Groningen, University of Groningen, Hanzeplein 1, 9713 GZ Groningen, The Netherlands
    Curr Hypertens Rep 7:379-84. 2005
    ....
  85. ncbi request reprint Physicians' attitudes towards treatment guidelines: differences between teaching and nonteaching hospitals
    Jacoba P Greving
    Department of Clinical Pharmacology, University Medical Center Groningen, A Deusinglaan 1, 9713 AV, Groningen, The Netherlands
    Eur J Clin Pharmacol 62:129-33. 2006
    ..To investigate whether physicians' attitudes towards treatment guidelines for primary and secondary care differ between teaching and nonteaching hospitals shortly before and 4 years after the guidelines' introduction...
  86. pmc initial angiotensin receptor blockade-induced decrease in albuminuria is associated with long-term renal outcome in type 2 diabetic patients with microalbuminuria: a post hoc analysis of the IRMA-2 trial
    Merel E Hellemons
    Department of Clinical Pharmacology, University ofGroningen, Groningen, The Netherlands
    Diabetes Care 34:2078-83. 2011
    ....
  87. doi request reprint Selection on albuminuria enhances the efficacy of screening for cardiovascular risk factors
    Akin Ozyilmaz
    Division of Nephrology, Department of Medicine, University Medical Center Groningen and University of Groningen, Groningen, The Netherlands
    Nephrol Dial Transplant 25:3560-8. 2010
    ..As albuminuria is easy to measure, we tested whether a screening approach in which detailed risk factor measurement is done only after selection of subjects with an elevated albuminuria results in a higher yield of subjects at risk...
  88. doi request reprint Immune modulation and graft protection by gene therapy in kidney transplantation
    Maria Sandovici
    Department of Clinical Pharmacology, Faculty of Medical Sciences, University Medical Center Groningen, The Netherlands
    Eur J Pharmacol 585:261-9. 2008
    ..In this article, we give an overview of the current state of gene therapy in experimental models of kidney transplantation...
  89. doi request reprint Screening and monitoring for albuminuria: the performance of the HemoCue point-of-care system
    Hiddo J Lambers Heerspink
    Department of Clinical Pharmacology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    Kidney Int 74:377-83. 2008
    ....
  90. pmc Is the randomized controlled drug trial in Europe lagging behind the USA?
    Hiddo J Lambers Heerspink
    Department of Clinical Pharmacology, University Medical Centre Groningen, University of Groningen, Groningen, The Netherlands
    Br J Clin Pharmacol 66:774-80. 2008
    ..The purpose of this study was to benchmark Europe's position on drugRCTs relative to the rest of the world, and to identify factors that may drive this performance...
  91. ncbi request reprint Endothelial dysfunction in chronic kidney disease: determinant of susceptibility to end-organ damage and therapeutic response
    Peter Ochodnicky
    Department of Clinical Pharmacology, University Medical Center Groningen UMCG and Groningen Institute for Drug Exploration GUIDE, University of Groningen, Groningen, The Netherlands
    J Nephrol 19:246-58. 2006
    ..Therefore, a specific manipulation of renal and systemic ED might provide benefits in various stages of CKD. ED thus may represent an ideal therapeutic target not only for treatment, but also for primary prevention of renal disease...
  92. ncbi request reprint Enhanced responses of blood pressure, renal function, and aldosterone to angiotensin I in the DD genotype are blunted by low sodium intake
    Frank G H van der Kleij
    Groningen University Institute for Drug Exploration, University Hospital, Hanzeplein 1, P O Box 30 001, 9700 RB Groningen, The Netherlands
    J Am Soc Nephrol 13:1025-33. 2002
    ..These results support the presence of gene-environment interactions between ACE genotypes and dietary sodium intake...
  93. ncbi request reprint Continuum of renoprotection with losartan at all stages of type 2 diabetic nephropathy: a post hoc analysis of the RENAAL trial results
    Giuseppe Remuzzi
    Clinical Research Center for Rare Diseases Aldo e Cele Daccò, Mario Negri Institute for Pharmacological Research, Via Gavazzeni 11, 24125 Bergamo, Italy
    J Am Soc Nephrol 15:3117-25. 2004
    ..Angiotensin II antagonism is a suitable and well-tolerated treatment for individuals with type 2 diabetes even with GFR levels approaching renal replacement therapy...
  94. ncbi request reprint Biochemical risk markers: a novel area for better prediction of renal risk?
    Erik M Stuveling
    Nephrol Dial Transplant 20:497-508. 2005
  95. ncbi request reprint Angiotensin II receptor antagonist telmisartan in isolated systolic hypertension (ARAMIS) study: efficacy and safety of telmisartan 20, 40 or 80 mg versus hydrochlorothiazide 12.5 mg or placebo
    Athanasios J Manolis
    Txanio General Hospital, Piraeus, Greece
    J Hypertens 22:1033-7. 2004
    ..5 mg, and are well tolerated, in lowering systolic blood pressure (SBP) in patients with isolated systolic hypertension (ISH)...
  96. ncbi request reprint Cost-effectiveness of early irbesartan treatment versus control (standard antihypertensive medications excluding ACE inhibitors, other angiotensin-2 receptor antagonists, and dihydropyridine calcium channel blockers) or late irbesartan treatment in patien
    Andrew J Palmer
    CORE Center for Outcomes Research, Buendtenmattstrasse 40, 4102 Binningen Basel, Switzerland
    Diabetes Care 27:1897-903. 2004
    ..The aim of this study was to determine the most cost-effective time point for initiation of irbesartan treatment in hypertensive patients with type 2 diabetes and renal disease...
  97. ncbi request reprint Renoprotection by blocking the RAAS in diabetic nephropathy--fact or fiction?
    Peter Rossing
    Nephrol Dial Transplant 21:2354-7; discussion 2357-8. 2006
  98. ncbi request reprint The rate of progression of renal disease may not be slower in women compared with men: a patient-level meta-analysis
    Tazeen H Jafar
    New England Medical Center, Tufts University School of Medicine, Boston, MA, USA
    Nephrol Dial Transplant 18:2047-53. 2003
    ..Therefore, we undertook this analysis to explore the independent association of renal disease progression with gender...
  99. ncbi request reprint The risk of developing end-stage renal disease in patients with type 2 diabetes and nephropathy: the RENAAL study
    William F Keane
    Department of Medicine, Hennepin County Medical Center, University of Minnesota Medical School, Minneapolis, Minnesota, USA
    Kidney Int 63:1499-507. 2003
    ..We examined the risk factors that predict loss of kidney function (doubling of serum creatinine) or ESRD (dialysis or transplantation) in patients with type 2 diabetes in whom blood pressure was controlled...
  100. ncbi request reprint A population-based screening for microalbuminuria among relatives of CKD patients: the Kidney Evaluation and Awareness Program in Sheffield (KEAPS)
    Aminu K Bello
    Sheffield Kidney Institute, The University of Sheffield, Sheffield, UK
    Am J Kidney Dis 52:434-43. 2008
    ..However, relatives of patients with CKD have not been investigated for microalbuminuria in the United Kingdom...
  101. ncbi request reprint Effect of losartan on microalbuminuria in normotensive patients with type 2 diabetes mellitus. A randomized clinical trial
    Adrienne A M Zandbergen
    Department of Internal Medicine, Ikazia Hospital and Erasmus University Medical Centre, Rotterdam, The Netherlands
    Ann Intern Med 139:90-6. 2003
    ..The effect of angiotensin-receptor antagonists in normotensive diabetic patients with microalbuminuria has not yet been reported...