Dick de Zeeuw

Summary

Affiliation: University of Groningen
Country: The Netherlands

Publications

  1. ncbi request reprint Albuminuria, a therapeutic target for cardiovascular protection in type 2 diabetic patients with nephropathy
    Dick de Zeeuw
    Department of Clinical Pharmacology, Groningen University Medical Center, Ant Deusinglaan 1, 9713 AV Groningen, Netherlands
    Circulation 110:921-7. 2004
  2. ncbi request reprint Proteinuria, a target for renoprotection in patients with type 2 diabetic nephropathy: lessons from RENAAL
    Dick de Zeeuw
    Department of Clinical Pharmacology, University Medical Center Groningen, Groningen, The Netherlands
    Kidney Int 65:2309-20. 2004
  3. ncbi request reprint Should albuminuria be a therapeutic target in patients with hypertension and diabetes?
    Dick de Zeeuw
    Department of Clinical Pharmacology, University Medical Center, Groningen, The Netherlands
    Am J Hypertens 17:11S-15S; quiz A2-4. 2004
  4. doi request reprint An acute fall in estimated glomerular filtration rate during treatment with losartan predicts a slower decrease in long-term renal function
    Frank A Holtkamp
    Department of Clinical Pharmacology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    Kidney Int 80:282-7. 2011
  5. ncbi request reprint Altered myogenic constriction and endothelium-derived hyperpolarizing factor-mediated relaxation in small mesenteric arteries of hypertensive subtotally nephrectomized rats
    Simone Vettoretti
    Department of Clinical Pharmacology, University Medical Center Groningen and Groningen Institute for Drug Exploration GUIDE, University of Groningen, The Netherlands
    J Hypertens 24:2215-23. 2006
  6. doi request reprint Gender differences in predictors of the decline of renal function in the general population
    Nynke Halbesma
    Division of Nephrology, Department of Medicine, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    Kidney Int 74:505-12. 2008
  7. ncbi request reprint Does angiotensin (1-7) contribute to the anti-proteinuric effect of ACE-inhibitors
    Els A Van der Wouden
    Department of Clinical Pharmocology, Division of Nephrology, Groningen University Institute for Drug Exploration GUIDE, University Medical Center Groningen, Groningen, The Netherlands
    J Renin Angiotensin Aldosterone Syst 6:96-101. 2005
  8. doi request reprint Renal endothelial function and blood flow predict the individual susceptibility to adriamycin-induced renal damage
    Peter Ochodnicky
    Department of Clinical Pharmacology, University Medical Center Groningen UMCG and Graduate School for Drug Exploration GUIDE, University of Groningen, The Netherlands
    Nephrol Dial Transplant 24:413-20. 2009
  9. ncbi request reprint Involvement of renal ACE activity in proteinuria-associated renal damage in untreated and treated adriamycin nephrotic rats
    Hendrik Bos
    Department of Nephrology, Groningen University, Groningen, The Netherlands
    J Renin Angiotensin Aldosterone Syst 4:106-12. 2003
  10. ncbi request reprint Renal function and risk for cardiovascular events in type 2 diabetic patients with hypertension: the RENAAL and LIFE studies
    Wouter B A Eijkelkamp
    Department of Clinical Pharmacology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    J Hypertens 25:871-6. 2007

Collaborators

Detail Information

Publications103 found, 100 shown here

  1. ncbi request reprint Albuminuria, a therapeutic target for cardiovascular protection in type 2 diabetic patients with nephropathy
    Dick de Zeeuw
    Department of Clinical Pharmacology, Groningen University Medical Center, Ant Deusinglaan 1, 9713 AV Groningen, Netherlands
    Circulation 110:921-7. 2004
    ..Albuminuria can be reduced with drugs that block the renin-angiotensin system (RAS). We questioned whether the short-term drug-induced change in albuminuria would predict the long-term cardioprotective efficacy of RAS intervention...
  2. ncbi request reprint Proteinuria, a target for renoprotection in patients with type 2 diabetic nephropathy: lessons from RENAAL
    Dick de Zeeuw
    Department of Clinical Pharmacology, University Medical Center Groningen, Groningen, The Netherlands
    Kidney Int 65:2309-20. 2004
    ....
  3. ncbi request reprint Should albuminuria be a therapeutic target in patients with hypertension and diabetes?
    Dick de Zeeuw
    Department of Clinical Pharmacology, University Medical Center, Groningen, The Netherlands
    Am J Hypertens 17:11S-15S; quiz A2-4. 2004
    ....
  4. doi request reprint An acute fall in estimated glomerular filtration rate during treatment with losartan predicts a slower decrease in long-term renal function
    Frank A Holtkamp
    Department of Clinical Pharmacology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    Kidney Int 80:282-7. 2011
    ..Hence, interpretation of trial results relying on slope-based GFR outcomes should separate the initial drug-induced GFR change from the subsequent long-term effect on GFR...
  5. ncbi request reprint Altered myogenic constriction and endothelium-derived hyperpolarizing factor-mediated relaxation in small mesenteric arteries of hypertensive subtotally nephrectomized rats
    Simone Vettoretti
    Department of Clinical Pharmacology, University Medical Center Groningen and Groningen Institute for Drug Exploration GUIDE, University of Groningen, The Netherlands
    J Hypertens 24:2215-23. 2006
    ..We investigated whether myogenic response and EDHF are altered in subtotally nephrectomized (sNX) rats and whether these changes are modifiable by chronic treatment with angiotensin-converting enzyme (ACE) inhibitor...
  6. doi request reprint Gender differences in predictors of the decline of renal function in the general population
    Nynke Halbesma
    Division of Nephrology, Department of Medicine, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    Kidney Int 74:505-12. 2008
    ..These studies show that there are gender differences in the standard predictors of the decline in renal function...
  7. ncbi request reprint Does angiotensin (1-7) contribute to the anti-proteinuric effect of ACE-inhibitors
    Els A Van der Wouden
    Department of Clinical Pharmocology, Division of Nephrology, Groningen University Institute for Drug Exploration GUIDE, University Medical Center Groningen, Groningen, The Netherlands
    J Renin Angiotensin Aldosterone Syst 6:96-101. 2005
    ..We conclude that systemic Ang (1-7) plays no major role in the anti-proteinuric and BPlowering effects of ACE-I in this rat model of adriamycin-induced nephrosis...
  8. doi request reprint Renal endothelial function and blood flow predict the individual susceptibility to adriamycin-induced renal damage
    Peter Ochodnicky
    Department of Clinical Pharmacology, University Medical Center Groningen UMCG and Graduate School for Drug Exploration GUIDE, University of Groningen, The Netherlands
    Nephrol Dial Transplant 24:413-20. 2009
    ..Here we hypothesized that individual differences in endothelial function in vitro and renal perfusion in vivo predict the severity of renal damage in a model of adriamycin-induced nephropathy...
  9. ncbi request reprint Involvement of renal ACE activity in proteinuria-associated renal damage in untreated and treated adriamycin nephrotic rats
    Hendrik Bos
    Department of Nephrology, Groningen University, Groningen, The Netherlands
    J Renin Angiotensin Aldosterone Syst 4:106-12. 2003
    ..Renal ACE activity is a consistent marker of individual differences in proteinuria-associated renal damage: further studies are needed to investigate a possible pathogenetic role in renal damage...
  10. ncbi request reprint Renal function and risk for cardiovascular events in type 2 diabetic patients with hypertension: the RENAAL and LIFE studies
    Wouter B A Eijkelkamp
    Department of Clinical Pharmacology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    J Hypertens 25:871-6. 2007
    ....
  11. doi request reprint Moderation of dietary sodium potentiates the renal and cardiovascular protective effects of angiotensin receptor blockers
    Hiddo J Lambers Heerspink
    Department of Clinical Pharmacology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    Kidney Int 82:330-7. 2012
    ..This underscores the avoidance of excessive sodium intake, particularly in type 2 diabetic patients receiving ARB therapy...
  12. ncbi request reprint Albuminuria is a target for renoprotective therapy independent from blood pressure in patients with type 2 diabetic nephropathy: post hoc analysis from the Reduction of Endpoints in NIDDM with the Angiotensin II Antagonist Losartan (RENAAL) trial
    Wouter B A Eijkelkamp
    Department of Clinical Pharmacology, University Medical Center Groningen, University of Groningen, Groningen, Netherlands
    J Am Soc Nephrol 18:1540-6. 2007
    ..Antihypertensive treatment that is aimed at improving renal outcomes in patients with diabetic nephropathy may therefore require a dual strategy, targeting both SBP and albuminuria reduction...
  13. ncbi request reprint Effects of fosinopril and pravastatin on cardiovascular events in subjects with microalbuminuria
    Folkert W Asselbergs
    Department of Clinical Pharmacology, University of Groningen, Groningen, The Netherlands
    Circulation 110:2809-16. 2004
    ..We assessed whether therapeutic intervention aimed at lowering urinary albumin excretion would reduce cardiovascular events in microalbuminuric subjects (15 to 300 mg/24 hours)...
  14. ncbi request reprint C-reactive protein modifies the relationship between blood pressure and microalbuminuria
    Erik M Stuveling
    Department of Medicine, University Medical Center, Groningen, The Netherlands
    Hypertension 43:791-6. 2004
    ..0004). No significant interactions between other risk factors and CRP with respect to the risk of microalbuminuria were encountered. Thus, CRP modifies the relation between blood pressure and microalbuminuria...
  15. ncbi request reprint Renal targeting of captopril using captopril-lysozyme conjugate enhances its antiproteinuric effect in adriamycin-induced nephrosis
    Willemijn A K M Windt
    Department of Clinical Pharmacology, Groningen University, Antonius Deusinglaan 1, 9713 AV Groningen, The Netherlands
    J Renin Angiotensin Aldosterone Syst 5:197-202. 2004
    ..We compared the antiproteinuric efficacy of captopril to that of the captopril-lysozyme conjugate in adriamycin-induced proteinuric rats fed with a high-sodium diet...
  16. ncbi request reprint Endothelial dysfunction and infarct-size relate to impaired EDHF response in rat experimental chronic heart failure
    Simone Gschwend
    Department of Clinical Pharmacology, University of Groningen, A Deusinglaan 1, 9713 AV, Groningen, The Netherlands
    Eur J Heart Fail 5:147-54. 2003
    ..Inconsistent results have been obtained concerning the role of endothelial dilative mediators nitric oxide (NO) and endothelium-derived hyperpolarizing factor (EDHF)...
  17. doi request reprint Effect of a reduction in uric acid on renal outcomes during losartan treatment: a post hoc analysis of the reduction of endpoints in non-insulin-dependent diabetes mellitus with the Angiotensin II Antagonist Losartan Trial
    Yan Miao
    Department of Clinical Pharmacology, University Medical Centre Groningen, Antonius Deusinglaan 1, 9713 AV, Groningen, The Netherlands
    Hypertension 58:2-7. 2011
    ..These findings support the view that SUA may be a modifiable risk factor for renal disease...
  18. ncbi request reprint Therapeutic resistance to angiotensin converting enzyme (ACE) inhibition is related to pharmacodynamic and -kinetic factors in 5/6 nephrectomized rats
    Willemijn A K M Windt
    Department of Clinical Pharmacology, Groningen Institute for Drug Evaluation, University Medical Center Groningen, University of Groningen, The Netherlands
    Eur J Pharmacol 580:231-40. 2008
    ..32, P=0.003). In conclusion, both pharmacodynamic and -kinetic factors account for the non-response to lisinopril. Whether these can be overcome simply by increasing drug dosage in non-responders should be investigated...
  19. doi request reprint Albuminuria and blood pressure, independent targets for cardioprotective therapy in patients with diabetes and nephropathy: a post hoc analysis of the combined RENAAL and IDNT trials
    Frank A Holtkamp
    Department of Clinical Pharmacology, University Medical Center Groningen, University of Groningen, Antonius Deusinglaan 1, Groningen, The Netherlands
    Eur Heart J 32:1493-9. 2011
    ....
  20. ncbi request reprint The association between atherosclerotic risk factors and renal function in the general population
    Jacobien C Verhave
    Department of Medicine, Division of Nephrology, Groningen University Medical Center, Groningen, The Netherlands
    Kidney Int 67:1967-73. 2005
    ..Generalized atherosclerosis is increasingly recognized as an important cause of end-stage renal disease (ESRD). We questioned to what extent atherosclerotic risk factors determine renal function in the general population...
  21. doi request reprint An initial reduction in serum uric acid during angiotensin receptor blocker treatment is associated with cardiovascular protection: a post-hoc analysis of the RENAAL and IDNT trials
    Paul A Smink
    Department of Clinical Pharmacology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    J Hypertens 30:1022-8. 2012
    ..Treatment with the angiotensin receptor blocker (ARB) losartan lowers SUA in contrast to other ARBs. Whether reductions in SUA during ARB therapy are associated with cardiovascular protection is unclear. We aimed to investigate this...
  22. ncbi request reprint Renal damage after myocardial infarction is prevented by renin-angiotensin-aldosterone-system intervention
    Willemijn A K M Windt
    Department of Clinical Pharmacology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    J Am Soc Nephrol 17:3059-66. 2006
    ..VPI treatment seemed to provide no additional renoprotection compared with sole ACEi after 6 wk of treatment in this model, despite a more pronounced ACE-inhibiting effect of VPI...
  23. ncbi request reprint Urinary albumin excretion as a predictor of the development of hypertension in the general population
    Auke H Brantsma
    Division of Nephrology, Department of Medicine, University Medical Center Groningen, PO Box 30 001, Groningen, 9700 RB The Netherlands
    J Am Soc Nephrol 17:331-5. 2006
    ..In conclusion, these findings support the hypothesis that mild renal damage may precede the development of hypertension...
  24. ncbi request reprint What predicts progression and regression of urinary albumin excretion in the nondiabetic population?
    Auke H Brantsma
    Division of Nephrology, Department of Medicine, University Medical Center Groningen, PO Box 30 001, 9700 RB Groningen, The Netherlands
    J Am Soc Nephrol 18:637-45. 2007
    ....
  25. ncbi request reprint Uptake of angiotensin II receptor blockers in the treatment of hypertension
    Jacoba P Greving
    Department of Clinical Pharmacology, University Medical Center Groningen, PO Box 196, 9700, AD, Groningen, The Netherlands
    Eur J Clin Pharmacol 61:461-6. 2005
    ..To examine trends in prescribing of angiotensin II receptor blockers (ARBs) as initial and second-line treatment of hypertension...
  26. doi request reprint Identifying targets to improve treatment in type 2 diabetes; the Groningen Initiative to aNalyse Type 2 diabetes Treatment (GIANTT) observational study
    Jaco Voorham
    Department of Clinical Pharmacology, Department of Epidemiology, University Medical Center Groningen, University of Groningen, The Netherlands
    Pharmacoepidemiol Drug Saf 19:1078-86. 2010
    ..Assessment of quality of cardiometabolic risk management in diabetes in primary care...
  27. doi request reprint Renal and cardio-protective effects of direct renin inhibition: a systematic literature review
    Hiddo J Lambers Heerspink
    Department of Clinical Pharmacology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    J Hypertens 27:2321-31. 2009
    ..This systematic review aims to delineate the effects of DRIs on surrogate markers of renal and cardiovascular function...
  28. ncbi request reprint Endothelial function predicts the development of renal damage after combined nephrectomy and myocardial infarction
    Peter Ochodnicky
    Department of Clinical Pharmacology, University Medical Centre Groningen, The Netherlands
    J Am Soc Nephrol 17:S49-52. 2006
    ..Further exploration of the underlying mechanisms may lead to discovery of preventive renoprotective therapies...
  29. pmc Comparison of different measures of urinary protein excretion for prediction of renal events
    Hiddo J Lambers Heerspink
    Department of Clinical Pharmacology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    J Am Soc Nephrol 21:1355-60. 2010
    ..In conclusion, measurement of the albumin:creatinine ratio in a first-morning void is the superior method to predict renal events in patients with type 2 diabetes and nephropathy...
  30. doi request reprint Is albuminuria screening and treatment optimal in patients with type 2 diabetes in primary care? Observational data of the GIANTT cohort
    Merel E Hellemons
    Department of Clinical Pharmacology, University Medical Center Groningen, Groningen, The Netherlands
    Nephrol Dial Transplant 28:706-15. 2013
    ..We evaluated guideline adherence and factors associated with albuminuria screening and treatment in T2DM patients in primary care...
  31. doi request reprint Association between performance measures and glycemic control among patients with diabetes in a community-wide primary care cohort
    Grigory Sidorenkov
    Department of Clinical Pharmacology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands
    Med Care 51:172-9. 2013
    ..Performance measures are used for assessing quality of care. Higher performance shown by these measures is expected to reflect better care, but little is known whether they predict better patient outcomes...
  32. ncbi request reprint Microalbuminuria and endothelial dysfunction: emerging targets for primary prevention of end-organ damage
    Peter Ochodnicky
    Department of Clinical Pharmacology, University Medical Center Groningen and Groningen Institute for Drug Exploration GUIDE, University of Groningen, The Netherlands
    J Cardiovasc Pharmacol 47:S151-62; discussion S172-6. 2006
    ..In near future, dietary components improving nitric oxide bioavailability, such as cocoa-derived flavanols may play important role in these preventive strategies...
  33. ncbi request reprint A central body fat distribution is related to renal function impairment, even in lean subjects
    Sara Joan Pinto-Sietsma
    Division of Nephrology, Department of Internal Medicine, University Hospital Groningen, Groningen, The Netherlands
    Am J Kidney Dis 41:733-41. 2003
    ..Whether this depends on fat distribution is not known. We hypothesize that in addition to overweight, fat distribution may be associated with renal function abnormalities...
  34. ncbi request reprint Beneficial effects of add-on hydrochlorothiazide in rats with myocardial infarction optimally treated with quinapril
    Bart Westendorp
    Department of Clinical Pharmacology, University of Groningen, The Netherlands
    Eur J Heart Fail 7:1085-94. 2005
    ..Therefore, we investigated whether hydrochlorothiazide (HCTZ) or dietary sodium restriction further improves survival in ACEi-treated rats with MI...
  35. pmc Impact of the preintervention rate of renal function decline on outcome of renoprotective intervention
    A Titia Lely
    Department of Internal Medicine, Division of Nephrology, University Medical Center Groningen, University of Groningen, Hanzeplein 1, 9713 GZ Groningen, Netherlands
    Clin J Am Soc Nephrol 3:54-60. 2008
    ..There are no data showing that this provides groups with similar baseline rates of renal function loss. Accordingly, the impact of preintervention rate of renal function loss (slope) on outcome of studies has not been established...
  36. doi request reprint Myocardial infarction does not further impair renal damage in 5/6 nephrectomized rats
    Willemijn A K M Windt
    Department of Clinical Pharmacology, University Medical Center Groningen, PO Box 196, NL 9700 AD, Groningen, The Netherlands
    Nephrol Dial Transplant 23:3103-10. 2008
    ..The effects of an MI on pre-existing severe renal function loss and the effects of RAAS intervention interrupting this hypothesized cardiorenal interaction are however unknown and clinically even more relevant...
  37. ncbi request reprint Early, but not late therapy with a vasopressin V1a-antagonist ameliorates the development of renal damage after 5/6 nephrectomy
    Willemijn A K M Windt
    Department of Clinical Pharmacology, Groningen Institute for Drug Evaluation GUIDE, University Medical Center Groningen, Antonius Deusinglaan 1 NL 9713 AV Groningen NL 9713, The Netherlands
    J Renin Angiotensin Aldosterone Syst 7:217-24. 2006
    ....
  38. ncbi request reprint The role of angiotensin(1-7) in renal vasculature of the rat
    Els A Van der Wouden
    Department of Clinical Pharmacology, Groningen University Institute for Drug Exploration, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    J Hypertens 24:1971-8. 2006
    ..Angiotensin(1-7) is an active component of the renin-angiotensin-aldosterone system. Its exact role in renal vascular function is unclear. We therefore studied the effects of angiotensin(1-7) on the renal vasculature in vitro and in vivo...
  39. pmc Differential effects of comorbidity on antihypertensive and glucose-regulating treatment in diabetes mellitus--a cohort study
    Jaco Voorham
    Department of Clinical Pharmacology, Faculty of Medical Science, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    PLoS ONE 7:e38707. 2012
    ..We hypothesized that these effects differ according to expected priority of the conditions...
  40. ncbi request reprint Myocardial infarction enhances progressive renal damage in an experimental model for cardio-renal interaction
    Richard P E van Dokkum
    Department of Clinical Pharmacology, University Medical Center Groningen, Antonius Deusinglaan 1, NL 9713 AV Groningen, The Netherlands
    J Am Soc Nephrol 15:3103-10. 2004
    ..Finding the underlying mechanism will enable improved protection for both kidneys and heart...
  41. ncbi request reprint Role of proteinuria in the regulation of renal renin-angiotensin system components in unilateral proteinuric rats
    Leo E Deelman
    Department of Clinical Pharmacology, University of Groningen, Groningen, 9713AV, The Netherlands
    J Renin Angiotensin Aldosterone Syst 4:38-42. 2003
    ..In conclusion, renal expression of ACE, AT2-R, and AT1-R mRNA is not mediated by protein leakage. Local intrarenal protein leakage did influence renal TGF-beta mRNA expression...
  42. ncbi request reprint Individual titration for maximal blockade of the renin-angiotensin system in proteinuric patients: a feasible strategy?
    Liffert Vogt
    Division Nephrology, Department of Medicine, Groningen University Medical Center, Groningen, The Netherlands
    J Am Soc Nephrol 16:S53-7. 2005
    ..To further improve renoprotective treatment strategies, it is important to explore other modes of antiproteinuric intervention in patients with residual proteinuria during RAS blockade...
  43. pmc Effects of dietary sodium and hydrochlorothiazide on the antiproteinuric efficacy of losartan
    Liffert Vogt
    Department of Internal Medicine, Division of Nephrology, University Medical Center Groningen, University of Groningen, Groningen, Netherlands
    J Am Soc Nephrol 19:999-1007. 2008
    ..Combining these interventions in sodium status is an effective method to maximize the antiproteinuric efficacy of RAAS blockade...
  44. ncbi request reprint The abnormal renal vasodilator response to D1-like receptor stimulation in conscious SHR can be normalized by AT1 blockade
    P A Marcel de Vries
    Departments of Clinical Pharmacology, Groningen University Institute for Drug Exploration GUIDE, State University, Groningen, The Netherlands
    J Cardiovasc Pharmacol 44:571-6. 2004
    ....
  45. doi request reprint Albuminuria assessed from first-morning-void urine samples versus 24-hour urine collections as a predictor of cardiovascular morbidity and mortality
    Hiddo J Lambers Heerspink
    Department of Clinical Pharmacology, University Medical Center Groningen, P O Box 30 001, 9700 RB Groningen, The Netherlands
    Am J Epidemiol 168:897-905. 2008
    ..To predict cardiovascular morbidity and all-cause mortality, measuring ACR in a first-morning-void urine sample is a good alternative to measuring 24-hour UAE...
  46. doi request reprint N-terminal pro-B-type natriuretic peptide is an independent predictor of cardiovascular morbidity and mortality in the general population
    Gerard C M Linssen
    Department of Cardiology, Thoraxcenter, University Medical Center Groningen, Hanzeplein 1, PO Box 30 001, 9700 RB Groningen, The Netherlands
    Eur Heart J 31:120-7. 2010
    ..However, their prognostic value in the general population is less well established. The purpose of our study was to investigate the prognostic properties of NT-proBNP for death and cardiovascular (CV) events in the general population...
  47. ncbi request reprint Do severe systemic sequelae of proteinuria modulate the antiproteinuric response to chronic ACE inhibition?
    Hendrik Bos
    Department of Clinical Pharmacology, Faculty of Medical Sciences and Groningen University Institute of Drug Exploration GUIDE, University of Groningen, The Netherlands
    Nephrol Dial Transplant 17:793-7. 2002
    ..In the present study we therefore investigated whether the severity of systemic nephrosis, estimated from plasma cholesterol, predicts residual proteinuria during ACE inhibition...
  48. ncbi request reprint Albuminuria: what can we expect from the determination of nonimmunoreactive albumin?
    Stephan J L Bakker
    Department of Internal Medicine, University Medical Center Groningen, Hanzeplein 1, 9713 GZ Groningen, The Netherlands
    Curr Hypertens Rep 11:111-7. 2009
    ....
  49. pmc Screening for albuminuria identifies individuals at increased renal risk
    Marije van der Velde
    Division of Nephrology, Department of Internal Medicine, University Medical Center Groningen, Groningen, The Netherlands
    J Am Soc Nephrol 20:852-62. 2009
    ..Screening for albuminuria identifies patients at increased risk for progressive renal disease, 40 to 50% of whom were previously undiagnosed or untreated...
  50. pmc First morning voids are more reliable than spot urine samples to assess microalbuminuria
    Elsbeth C Witte
    Department of Nephrology, University Medical Center Groningen, University of Groningen, Antonius Deusinglaan 1, 9713 AV Groningen, The Netherlands
    J Am Soc Nephrol 20:436-43. 2009
    ..In conclusion, measurement of albuminuria in a first morning void, preferably as the ACR, is more reliable than a spot urine sample to diagnose and monitor microalbuminuria...
  51. doi request reprint Effect of the urotensin receptor antagonist palosuran in hypertensive patients with type 2 diabetic nephropathy
    Liffert Vogt
    University Medical Center Groningen, University of Groningen, Hanzeplein 1, 9713 GZ Groningen, The Netherlands
    Hypertension 55:1206-9. 2010
    ..These results question whether urotensin receptor antagonism represents a new treatment strategy in this high-risk patient population...
  52. doi request reprint Albuminuria, estimated GFR, traditional risk factors, and incident cardiovascular disease: the PREVEND (Prevention of Renal and Vascular Endstage Disease) study
    Paul A Smink
    Department of Clinical Pharmacology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    Am J Kidney Dis 60:804-11. 2012
    ..This study assessed the contribution of each separately in correctly identifying individuals at cardiovascular risk in the general population beyond traditional risk markers...
  53. doi request reprint Influence of age on the prognostic value of mid-regional pro-adrenomedullin in the general population
    Frank P Brouwers
    Department of Cardiology, University Medical Center Groningen, University of Groningen, The Netherlands
    Heart 98:1348-53. 2012
    ..The aim of this study was to evaluate the prognostic performance of MR-proADM in the general population, controlling for these potential confounders...
  54. pmc A longitudinal study examining adherence to guidelines in diabetes care according to different definitions of adequacy and timeliness
    Grigory Sidorenkov
    Department of Clinical Pharmacology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    PLoS ONE 6:e24278. 2011
    ..We assessed quality of diabetes care by looking at single processes versus clinical pathways. In addition, we evaluated the impact of time period definitions on this quality assessment...
  55. ncbi request reprint Apparent loss of urinary albumin during long-term frozen storage: HPLC vs immunonephelometry
    Jacoline W Brinkman
    Department of Clinical Pharmacology, University Medical Center Groningen and University of Groningen, Groningen, The Netherlands
    Clin Chem 53:1520-6. 2007
    ..We investigated whether this technique is affected by sample temperature, particularly freezing...
  56. ncbi request reprint Macroalbuminuria is a better risk marker than low estimated GFR to identify individuals at risk for accelerated GFR loss in population screening
    Nynke Halbesma
    Division of Nephrology, Department of Medicine, University Medical Center Groningen, P O Box 30 001, 9700 RB Groningen, The Netherlands
    J Am Soc Nephrol 17:2582-90. 2006
    ..However, macroalbuminuria is a better risk marker than low eGFR or erythrocyturia to identify in population screening of individuals who are at risk for accelerated GFR loss...
  57. doi request reprint Cardiovascular and renal outcome in subjects with K/DOQI stage 1-3 chronic kidney disease: the importance of urinary albumin excretion
    Auke H Brantsma
    Division of Nephrology, Department of Internal Medicine, University Medical Center Groningen, Groningen, The Netherlands
    Nephrol Dial Transplant 23:3851-8. 2008
    ..In this study we evaluated cardiovascular and renal outcome in subjects with stage 1 and 2 CKD. For comparison, we also studied these outcomes in stage 3 CKD...
  58. ncbi request reprint Microalbuminuria as an early marker for cardiovascular disease
    Dick de Zeeuw
    Department of Clinical Pharmacology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    J Am Soc Nephrol 17:2100-5. 2006
    ..In conclusion, albuminuria seems to be a sensitive marker very early in life for the susceptibility of an individual to CV disease. It therefore may be an ideal target for early primary prevention using CV-protective therapy regimens...
  59. ncbi request reprint Urinary albumin excretion and its relation with C-reactive protein and the metabolic syndrome in the prediction of type 2 diabetes
    Auke H Brantsma
    Division of Nephrology, Department of Medicine, University Medical Center Groningen, P O Box 30, 001, 9700 RB, Groningen, Netherlands
    Diabetes Care 28:2525-30. 2005
    ..To investigate urinary albumin excretion (UAE) and its relation with C-reactive protein (CRP) and the metabolic syndrome in the prediction of the development of type 2 diabetes...
  60. ncbi request reprint Dietary sodium restriction specifically potentiates left ventricular ACE inhibition by zofenopril, and is associated with attenuated hypertrophic response in rats with myocardial infarction
    Bart Westendorp
    Department of Clinical Pharmacology, University of Groningen, Groningen, The Netherlands
    J Renin Angiotensin Aldosterone Syst 5:27-32. 2004
    ..In line with the latter, the aim of the present study was to explore whether dietary sodium restriction enhances the efficacy of ACE-I after MI...
  61. ncbi request reprint The angiotensin II receptor antagonist telmisartan reduces urinary albumin excretion in patients with isolated systolic hypertension: results of a randomized, double-blind, placebo-controlled trial
    Liffert Vogt
    Department of Clinical Pharmacology and Internal Medicine, Division of Nephrology, University Medical Center, University of Groningen, The Netherlands
    J Hypertens 23:2055-61. 2005
    ....
  62. pmc Extended prognostic value of urinary albumin excretion for cardiovascular events
    Auke H Brantsma
    Division of Nephrology, Department of Medicine, University Medical Center Groningen, P O Box 30 001, 9700 RB Groningen, The Netherlands
    J Am Soc Nephrol 19:1785-91. 2008
    ..Future studies are required to determine the optimal interval of repeat testing and its cost-effectiveness...
  63. ncbi request reprint Endothelial dilatory function predicts individual susceptibility to renal damage in the 5/6 nephrectomized rat
    Simone Gschwend
    Department of Clinical Pharmacology, University of Groningen, A Deusinglaan 1, 9713 AV Groningen, The Netherlands
    J Am Soc Nephrol 13:2909-15. 2002
    ..This study demonstrates for the first time that individual renal endothelial dilatory function of the healthy rat predicts susceptibility to renal damage after 5/6 Nx, which seems to depend on individual endothelial NO and PG activity...
  64. ncbi request reprint Renoprotective therapy: is it blood pressure or albuminuria that matters?
    Paul E de Jong
    Division of Nephrology, Department of Medicine, University Medical Center Groningen, 9713 GZ Groningen, Netherlands
    Lancet 365:913-4. 2005
  65. ncbi request reprint [Quality of the treatment of type 2 diabetes: results from the GIANTT project 2004-2007]
    Jaco Voorham
    Universitair Medisch Centrum Groningen, Afd Klinische Farmacologie, Groningen, The Netherlands
    Ned Tijdschr Geneeskd 154:A775. 2010
    ..To describe the quality of diabetes care at the primary care level using the risk factors HbA1c, blood pressure and LDL cholesterol...
  66. ncbi request reprint Effect of first myocardial ischemic event on renal function
    Wouter B A Eijkelkamp
    Department of Clinical Pharmacology, Division of Nephrology, University Medical Center Groningen, Groningen, The Netherlands
    Am J Cardiol 100:7-12. 2007
    ....
  67. ncbi request reprint C-reactive protein and microalbuminuria differ in their associations with various domains of vascular disease
    Erik M Stuveling
    Department of Internal Medicine, University Medical Centre Groningen, Groningen, The Netherlands
    Atherosclerosis 172:107-14. 2004
    ..Thus, CRP and MA are risk markers for vascular disease, each showing a different risk profiling for different vascular beds...
  68. ncbi request reprint Update on microalbuminuria as a biomarker in renal and cardiovascular disease
    Hiddo J Lambers Heerspink
    Department of Clinical Pharmacology, The Netherlands bDepartment of Internal Medicine, The Netherlands
    Curr Opin Nephrol Hypertens 15:631-6. 2006
    ..To discuss recently published papers on the potential use of albuminuria as a predictor of cardiovascular and renal disease...
  69. ncbi request reprint Low sodium modifies the vascular effects of angiotensin-converting enzyme inhibitor therapy in healthy rats
    Menno J A Kocks
    Department of Clinical Pharmacology, University of Groningen, Antonius Deusinglaan 1, 9713 AV Groningen, The Netherlands
    J Pharmacol Exp Ther 310:1183-9. 2004
    ..These findings provide a rationale for further studies addressing the mechanism-of-actions of our therapies to find additional strategies to improve therapy response...
  70. ncbi request reprint Evaluation of measures of urinary albumin excretion
    Ronald T Gansevoort
    Department of Nephrology, University Medical Center, Groningen, The Netherlands
    Am J Epidemiol 164:725-7. 2006
    ..Consequently, values for the within-person coefficient of variation will therefore be different when they are measured in a portion of a 24-hour urine collection in comparison with a spot morning urine sample...
  71. ncbi request reprint Addition of AT1 blocker fails to overcome resistance to ACE inhibition in adriamycin nephrosis
    Hendrik Bos
    Department of Clinical Pharmacology, Faculty of Medical Sciences and Groningen University Institute of Drug Exploration GUIDE, University of Groningen, Groningen, The Netherlands
    Kidney Int 61:473-80. 2002
    ..We studied whether co-treatment with an angiotensin II subtype 1 (AT1) receptor antagonist (AII-A) improves the individual antiproteinuric response of maximal ACE inhibition in established adriamycin nephrosis...
  72. ncbi request reprint Impaired coronary endothelial function in a rat model of spontaneous albuminuria
    Simone Gschwend
    Department of Clinical Pharmacology, Division of Nephrology, University of Groningen, Groningen, The Netherlands
    Kidney Int 62:181-91. 2002
    ..Our aim was to investigate if the MWF strain shows generalized endothelial dysfunction or endothelial dysfunction localized to the coronary vascular bed, and if so, determine which endothelial dilative mediators are involved...
  73. ncbi request reprint Albuminuria: a target for treatment of type 2 diabetic nephropathy
    Dick de Zeeuw
    Department of Clinical Pharmacology, University Medical Center Groningen, University of Groningen, Ant Deusinglaan 1, 9713 AV Groningen, The Netherlands
    Semin Nephrol 27:172-81. 2007
    ....
  74. ncbi request reprint Renoprotection: a matter of blood pressure reduction or agent-characteristics?
    Liffert Vogt
    Department of Internal Medicine, Division of Nephrology, University Hospital, Groningen, The Netherlands
    J Am Soc Nephrol 13:S202-7. 2002
    ..Future studies should further explore the renoprotective benefit of non-antihypertensive intervention measures, alone and in combination with antihypertensive strategies...
  75. ncbi request reprint Normalization of aortic function during arousal episodes in the hibernating ground squirrel
    Robert H Henning
    Groningen University Institute for Drug Exploration, Department of Clinical Pharmacology, Faculty of Medical Sciences, The Netherlands
    Life Sci 70:2071-83. 2002
    ..In addition, involvement of NO in agonist-mediated relaxation differs between the various stages of hibernation.Thus, hibernating animals have effectively developed mechanisms to preserve vascular function after cooling and rewarming...
  76. doi request reprint Selective vitamin D receptor activation with paricalcitol for reduction of albuminuria in patients with type 2 diabetes (VITAL study): a randomised controlled trial
    Dick de Zeeuw
    University Medical Centre Groningen, University of Groningen, Groningen, Netherlands
    Lancet 376:1543-51. 2010
    ..We aimed to assess whether paricalcitol could be used to reduce albuminuria in patients with diabetic nephropathy...
  77. ncbi request reprint Low sodium diet inhibits the local counter-regulator effect of angiotensin-(1-7) on angiotensin II
    Anton J M Roks
    Department of Clinical Pharmacology, Groningen University Institute for Drug Exploration GUIDE, University of Groningen, Groningen, The Netherlands
    J Hypertens 22:2355-61. 2004
    ..The role of angiotensin receptor subtypes and the endothelium was assessed...
  78. doi request reprint Renal disease: a common and a silent killer
    Dick de Zeeuw
    Department of Clinical Pharmacology, University Medical Center, Groningen, The Netherlands
    Nat Clin Pract Cardiovasc Med 5:S27-35. 2008
    ....
  79. ncbi request reprint Best practice for hypertensive patients with kidney disease
    Dick de Zeeuw
    Department of Clinical Pharmacology, University of Groningen, Ant Deusingglaan 1, 9713 AV Groningen, The Netherlands
    Hosp Med 64:96-100. 2003
    ..The US National Kidney Foundation guidelines recommend that angiotensin-converting enzyme inhibitors and angiotensin type receptor antagonists are first choice therapy for these patients...
  80. ncbi request reprint Optimal blood pressure control and antihypertensive regimens in hypertensive renal disease: the potential of exploring the mechanisms of response variability
    Menno J A Kocks
    Kidney Center, State University, Groningen, The Netherlands
    Curr Opin Nephrol Hypertens 11:135-40. 2002
    ..However, therapy response is a complex phenotype. Thus, careful study of gene-gene and gene-environment interactions will be needed in order to turn this type of knowledge into benefit for the patient...
  81. ncbi request reprint Does comorbidity explain trends in prescribing of newer antihypertensive agents?
    Jacoba P Greving
    Department of Clinical Pharmacology, University of Groningen, The Netherlands
    J Hypertens 22:2209-15. 2004
    ..The association between comorbidity and trends in prescribing of angiotensin-converting enzyme inhibitors (ACE-I) and angiotensin II receptor blockers (ARBs) was examined for the period 1996-2000...
  82. ncbi request reprint Coronary myogenic constriction antagonizes EDHF-mediated dilation: role of KCa channels
    Simone Gschwend
    Department of Clinical Pharmacology, University of Groningen, A Deusinglaan 1, 9713 AV Groningen, The Netherlands
    Hypertension 41:912-8. 2003
    ..Activation of KCa channels with NS1619 reduces myogenic constriction and profoundly increases EDHF-mediated dilation, specifically in coronary arteries, suggesting a potential therapeutic impact to reduce coronary risk in hypertension...
  83. ncbi request reprint Approaches and methods in gene therapy for kidney disease
    Els A Van der Wouden
    Department of Clinical Pharmacology, University of Groningen, A Deusinglaan 1, 9713 AV Groningen, The Netherlands
    J Pharmacol Toxicol Methods 50:13-24. 2004
    ..Moreover, the development of safer, nonimmunogenic vectors and the large-scale production could make clinical renal gene therapy a realistic possibility for the near future...
  84. ncbi request reprint Effects of anti-proteinuric therapy with angiotensin-converting-enzyme inhibition on renal protein catabolism in the adriamycin-induced nephrotic rat
    Marijke Haas
    Department of Clinical Pharmacology, Groningen University Institute for Drug Exploration, University of Groningen, P O Box 196, NL 9700 AD Groningen, The Netherlands
    Clin Sci (Lond) 105:51-7. 2003
    ..Taken together, the data suggest that proteinuria is toxic for the proximal tubular cells and that ACE inhibition protects the remaining functional tubular cells directly against destruction through decreasing hypercatabolism...
  85. ncbi request reprint Between-patient differences in the renal response to renin-angiotensin system intervention: clue to optimising renoprotective therapy?
    Gozewijn D Laverman
    Division of Nephrology, University Hospital Groningen, Groningen, 9713, The Netherlands
    J Renin Angiotensin Aldosterone Syst 3:205-13. 2002
    ....
  86. ncbi request reprint Cardiovascular risk factors are differently associated with urinary albumin excretion in men and women
    Jacobien C Verhave
    Division of Nephrology, Department of Medicine, University Medical Center Groningen, Groningen University Institute of Drug Exploration GUIDE, Hanzeplein 1, 9713 GZ Groningen, The Netherlands
    J Am Soc Nephrol 14:1330-5. 2003
    ..It is concluded that gender differences exist in the association between cardiovascular risk factors and UAE. This is consistent with a larger vascular susceptibility to these risk factors in men as compared with women...
  87. ncbi request reprint Cost-effectiveness of early irbesartan treatment versus control (standard antihypertensive medications excluding ACE inhibitors, other angiotensin-2 receptor antagonists, and dihydropyridine calcium channel blockers) or late irbesartan treatment in patien
    Andrew J Palmer
    CORE Center for Outcomes Research, Buendtenmattstrasse 40, 4102 Binningen Basel, Switzerland
    Diabetes Care 27:1897-903. 2004
    ..The aim of this study was to determine the most cost-effective time point for initiation of irbesartan treatment in hypertensive patients with type 2 diabetes and renal disease...
  88. ncbi request reprint Renal function as a predictor of outcome in a broad spectrum of patients with heart failure
    Hans L Hillege
    Medical Center Groningen, University of Groningen, The Netherlands
    Circulation 113:671-8. 2006
    ..The aim of this analysis was to evaluate the prognostic importance of renal function in a broader spectrum of patients with CHF...
  89. ncbi request reprint Dual renin-angiotensin system blockade at optimal doses for proteinuria
    Gozewijn D Laverman
    Division of Nephrology, Faculty of Medical Sciences, University of Groningen, Hanzeplein 1, 9713 GZ Groningen, The Netherlands
    Kidney Int 62:1020-5. 2002
    ..The antiproteinuric effect of combining the angiotensin-converting enzyme (ACE) inhibitor lisinopril and the angiotensin II (Ang II) antagonist losartan was compared to that of the optimal antiproteinuric doses of monotherapy...
  90. ncbi request reprint Renoprotection by blocking the RAAS in diabetic nephropathy--fact or fiction?
    Peter Rossing
    Nephrol Dial Transplant 21:2354-7; discussion 2357-8. 2006
  91. ncbi request reprint Effect of losartan on microalbuminuria in normotensive patients with type 2 diabetes mellitus. A randomized clinical trial
    Adrienne A M Zandbergen
    Department of Internal Medicine, Ikazia Hospital and Erasmus University Medical Centre, Rotterdam, The Netherlands
    Ann Intern Med 139:90-6. 2003
    ..The effect of angiotensin-receptor antagonists in normotensive diabetic patients with microalbuminuria has not yet been reported...
  92. ncbi request reprint The COOPERATE trial
    Liffert Vogt
    Lancet 361:1055-6. 2003
  93. ncbi request reprint Enhanced responses of blood pressure, renal function, and aldosterone to angiotensin I in the DD genotype are blunted by low sodium intake
    Frank G H van der Kleij
    Groningen University Institute for Drug Exploration, University Hospital, Hanzeplein 1, P O Box 30 001, 9700 RB Groningen, The Netherlands
    J Am Soc Nephrol 13:1025-33. 2002
    ..These results support the presence of gene-environment interactions between ACE genotypes and dietary sodium intake...
  94. ncbi request reprint Definition and classification of chronic kidney disease: a position statement from Kidney Disease: Improving Global Outcomes (KDIGO)
    Andrew S Levey
    Tufts New England Medical Center, Boston, Massachusetts 02111, USA
    Kidney Int 67:2089-100. 2005
    ..Kidney disease treatment by dialysis and transplantation should be noted. Simple, uniform classifications of CKD by cause and by risks for kidney disease progression and CVD should be developed...
  95. ncbi request reprint Progression of chronic kidney disease: the role of blood pressure control, proteinuria, and angiotensin-converting enzyme inhibition: a patient-level meta-analysis
    Tazeen H Jafar
    Tufts New England Medical Center, Boston, Massachusetts 02111, USA
    Ann Intern Med 139:244-52. 2003
    ..Angiotensin-converting enzyme (ACE) inhibitors reduce blood pressure and urine protein excretion and slow the progression of chronic kidney disease...
  96. ncbi request reprint Importance of baseline distribution of proteinuria in renal outcomes trials: lessons from the reduction of endpoints in NIDDM with the angiotensin II antagonist losartan (RENAAL) study
    Zhongxin Zhang
    Merck and Co, Inc, P O Box 4, BL 3 4, West Point, PA 19486, USA
    J Am Soc Nephrol 16:1775-80. 2005
    ....
  97. ncbi request reprint A French cost-consequence analysis of the renoprotective benefits of irbesartan in patients with type 2 diabetes and hypertension
    Andrew J Palmer
    CORE Center for Outcomes Research, Allschwil Basel, Switzerland
    Curr Med Res Opin 22:2095-100. 2006
    ..We performed a cost-consequence analysis in a French setting of the renoprotective benefit of irbesartan in hypertensive type 2 diabetes patients over a 25-year period...
  98. ncbi request reprint Angiotensin II receptor antagonist telmisartan in isolated systolic hypertension (ARAMIS) study: efficacy and safety of telmisartan 20, 40 or 80 mg versus hydrochlorothiazide 12.5 mg or placebo
    Athanasios J Manolis
    Txanio General Hospital, Piraeus, Greece
    J Hypertens 22:1033-7. 2004
    ..5 mg, and are well tolerated, in lowering systolic blood pressure (SBP) in patients with isolated systolic hypertension (ISH)...
  99. ncbi request reprint Rationale--Trial to Reduce Cardiovascular Events with Aranesp Therapy (TREAT): evolving the management of cardiovascular risk in patients with chronic kidney disease
    T Christian H Mix
    Department of Development and Medical Affairs, Amgen Inc, Thousand Oaks, Calif, USA
    Am Heart J 149:408-13. 2005
    ....
  100. ncbi request reprint Continuum of renoprotection with losartan at all stages of type 2 diabetic nephropathy: a post hoc analysis of the RENAAL trial results
    Giuseppe Remuzzi
    Clinical Research Center for Rare Diseases Aldo e Cele Daccò, Mario Negri Institute for Pharmacological Research, Via Gavazzeni 11, 24125 Bergamo, Italy
    J Am Soc Nephrol 15:3117-25. 2004
    ..Angiotensin II antagonism is a suitable and well-tolerated treatment for individuals with type 2 diabetes even with GFR levels approaching renal replacement therapy...
  101. pmc Renal targeting of captopril selectively enhances the intrarenal over the systemic effects of ACE inhibition in rats
    R Folgert G Haverdings
    Department of Pharmacokinetics and Drug Delivery, University of Groningen, The Netherlands
    Br J Pharmacol 136:1107-16. 2002
    ..5 These data demonstrate that intravenous administration of a captopril-lysozyme conjugate leads to more selective renal ACE inhibition and enhanced renal effects as well as less systemic effects compared to captopril itself...