Research Topics
Species | Wiepke CahnSummaryAffiliation: University Medical Center Country: The Netherlands Publications
| Collaborators
|
Detail Information
Publications
Brain volume changes in first-episode schizophrenia: a 1-year follow-up studyWiepke Cahn
Department of Psychiatry, University Medical Center Utrecht, Heidelberglaan 100, 3584 CX Utrecht, The Netherlands
Arch Gen Psychiatry 59:1002-10. 2002..One would expect global gray matter to decrease progressively, particularly in first-episode patients, because clinical deterioration is greatest in the early stages of the disease...
Tract-based analysis of magnetization transfer ratio and diffusion tensor imaging of the frontal and frontotemporal connections in schizophreniaRene C W Mandl
Department of Psychiatry, Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, Heidelberglaan 100, 3584 CX Utrecht, The Netherlands
Schizophr Bull 36:778-87. 2010..Focal reductions in myelin have been suggested in patients using magnetization transfer ratio (MTR) imaging but to what extent schizophrenia may be related to changes in MTR measured along entire fiber bundles is still unknown...
Changes in cortical thickness during the course of illness in schizophreniaNeeltje E M van Haren
Rudolf Magnus Institute of Neuroscience, Department of Psychiatry, University Medical Center Utrecht, Heidelberglaan, The Netherlands
Arch Gen Psychiatry 68:871-80. 2011..Whether cortical thickness changes in schizophrenia over time are more pronounced relative to the changes that can be attributed to normal aging has not been studied...- Focal and global brain measurements in siblings of patients with schizophreniaHeleen B M Boos
Rudolf Magnus Institute of Neuroscience, Department of Psychiatry, University Medical Center Utrecht, The Netherlands
Schizophr Bull 38:814-25. 2012..This large magnetic resonance imaging study examined brain structures in patients with schizophrenia, their nonpsychotic siblings, and healthy control subjects using global and focal brain measurements... - Differences in craving for cannabis between schizophrenia patients using risperidone, olanzapine or clozapineMarise Machielsen
Department of Psychiatry, Academic Medical Centre, Amsterdam, The Netherlands
J Psychopharmacol 26:189-95. 2012..Risperidone and clozapine show a maximal difference in D(2) receptor occupancy rate, dissociation rate and D(1)/D(2) ratio. Olanzapine is intermediate between risperidone and clozapine in these characteristics... - Classification of schizophrenia patients and healthy controls from structural MRI scans in two large independent samplesMireille Nieuwenhuis
Department of Psychiatry, Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, P O Box 85500 3508 GA Utrecht, The Netherlands
Neuroimage 61:606-12. 2012..Larger training samples gave more reliable models: Models based on sample sizes smaller than N=130 should be considered unstable and can even score below chance... - Cannabis use and progressive cortical thickness loss in areas rich in CB1 receptors during the first five years of schizophreniaMonica Rais
Rudolf Magnus Institute of Neuroscience, Department of Psychiatry, University Medical Center Utrecht, Utrecht, The Netherlands
Eur Neuropsychopharmacol 20:855-65. 2010..First-episode schizophrenia patients who use cannabis show a more pronounced cortical thinning than non-using patients in areas known for their high density of CB1 receptors, such as the ACC and the DLPFC... - Duration of untreated illness in schizophrenia is not associated with 5-year brain volume changeGeartsje Boonstra
Department of Psychiatry, University Medical Center Utrecht, P B 85500, 3508 GA, Utrecht, The Netherlands
Schizophr Res 132:84-90. 2011..We aimed to investigate the relationship between DUI, outcome and brain volume at illness onset or brain volume change during the first five years of the illness in first-episode patients... - Hippocampal volume change in schizophreniaP Cédric M P Koolschijn
Rudolf Magnus Institute of Neuroscience, Department of Psychiatry, A 01 126, University Medical Center Utrecht, PO Box 85060, 3584 CX Utrecht, The Netherlands
J Clin Psychiatry 71:737-44. 2010..The aim of this study is to examine the extent to which hippocampal volume change in patients with schizophrenia is confounded by effects of age and/or antipsychotic medication... - Focal gray matter changes in schizophrenia across the course of the illness: a 5-year follow-up studyNeeltje E M van Haren
Department of Psychiatry, Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, Utrecht, The Netherlands
Neuropsychopharmacology 32:2057-66. 2007..Moreover, the progression in left frontal density loss appears to be related to an increased number of psychotic episodes, with atypical antipsychotic medication attenuating these changes... - Excessive brain volume loss over time in cannabis-using first-episode schizophrenia patientsMonica Rais
Department of Psychiatry, University Medical Center Utrecht, Heidelberglaan 100, 3584CX Utrecht, The Netherlands
Am J Psychiatry 165:490-6. 2008..Progressive gray matter changes in patients who use cannabis may be more extensive than in those who do not... - Progressive brain volume loss in schizophrenia over the course of the illness: evidence of maturational abnormalities in early adulthoodNeeltje E M van Haren
Department of Psychiatry, Rudolf Magnus Institute of Neuroscience, University Medical Center, Utrecht, The Netherlands
Biol Psychiatry 63:106-13. 2008..Thus, one would expect the progression in brain volume change in schizophrenia to follow a more complex trajectory over time... - Brain volumes in relatives of patients with schizophrenia: a meta-analysisHeleen B M Boos
Department of Psychiatry, Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, 3508 GA Utrecht, The Netherlands
Arch Gen Psychiatry 64:297-304. 2007..Although several studies have investigated brain volumes in nonpsychotic relatives of patients with schizophrenia, results have been inconsistent... - Brain volumes as predictor of outcome in recent-onset schizophrenia: a multi-center MRI studyNeeltje E M van Haren
Department of Psychiatry A 01 126, University Medical Center Utrecht, 3584 CX Utrecht, The Netherlands
Schizophr Res 64:41-52. 2003..No significant correlations were found between the brain volume measures and any of these measures. Gray matter volume at illness onset does not predict outcome after 2 years in recent-onset schizophrenia... - Brain volume changes after withdrawal of atypical antipsychotics in patients with first-episode schizophreniaGeartsje Boonstra
Department of Psychiatry, Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, The Netherlands
J Clin Psychopharmacol 31:146-53. 2011..We found evidence suggestive of decreasing volumes of the putamen and nucleus accumbens over time after discontinuation of medication. This might suggest that discontinuation reverses effects of atypical medication... - Verbal memory in first-episode schizophrenia: heterogeneity in performance?Jasper Nuyen
Rudolf Magnus Institute of Neuroscience, Department of Psychiatry, University Medical Center, Utrecht, The Netherlands
J Int Neuropsychol Soc 11:152-62. 2005..Our results may suggest that combining the verbal memory performance of first-episode patients obscures meaningful heterogeneity. Alternatively, the cluster solution could merely reflect a continuum of severity... - Predictive value of cognition for different domains of outcome in recent-onset schizophreniaEsther A E Holthausen
University Medical Center Groningen, Department of Psychiatry, P O Box 30 001, 9700 RB Groningen, The Netherlands
Psychiatry Res 149:71-80. 2007..It seems that cognition most strongly predicts work performance, where having a cognitive deficit, regardless of the nature of the deficit, acts as a rate-limiting factor... - Microglia activation in recent-onset schizophrenia: a quantitative (R)-[11C]PK11195 positron emission tomography studyBart N Van Berckel
Department of Psychiatry, Rudolf Magnus Institute for Neuroscience, University Medical Center Utrecht, Utrecht, The Netherlands
Biol Psychiatry 64:820-2. 2008..Microglia activation can be quantified in vivo using (R)-[(11)C]PK11195 and positron emission tomography (PET). The purpose of this study was to investigate whether microglia activation occurs in patients with recent-onset schizophrenia... - More prolonged brain activity related to gaze cueing in schizophreniaMaurice J C M Magnée
Rudolf Magnus Institute of Neuroscience, Department of Child and Adolescent Psychiatry, University Medical Center, Heidelberglaan 100, 3584 CX Utrecht, The Netherlands
Clin Neurophysiol 122:506-11. 2011..Event Related Potentials (ERPs) can very accurately pinpoint the shifting of attention, and can therefore shed more light on cueing abilities in schizophrenia... - Expression QTL analysis of top loci from GWAS meta-analysis highlights additional schizophrenia candidate genesSimone de Jong
Department of Medical Genetics, University Medical Center Utrecht, Utrecht, The Netherlands
Eur J Hum Genet 20:1004-8. 2012..Our results identify new genes of interest and highlight again the involvement of the MHC region in schizophrenia susceptibility... - Cerebrospinal fluid D-serine and glycine concentrations are unaltered and unaffected by olanzapine therapy in male schizophrenic patientsSabine A Fuchs
Department of Metabolic and Endocrine Diseases and Department of Biomedical Genetics, University Medical Center Utrecht, Utrecht, The Netherlands
Eur Neuropsychopharmacol 18:333-8. 2008.... - Association study of copy number variants with brain volume in schizophrenia patients and healthy controlsAfke Terwisscha van Scheltinga
Department of Psychiatry, Rudolf Magnus Institute of Neuroscience, University Medical Centre Utrecht, Huispostnummer A00 241, Heidelberglaan 100, 3584 CX, Utrecht, The Netherlands
Psychiatry Res 200:1011-3. 2012..Although this could suggest a causal relationship, we found no association between global CNV burden and three brain volume measures (on a MRI scan) in a sample of 173 schizophrenia patients and 176 healthy controls... - Effects of exercise therapy on cardiorespiratory fitness in patients with schizophreniaThomas W Scheewe
Department of Psychiatry, Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, Utrecht, The Netherlands
Med Sci Sports Exerc 44:1834-42. 2012..We compared CRF in patients with schizophrenia to CRF of matched healthy controls and reference values. Also, we examined the effects of exercise therapy on CRF in patients with schizophrenia and in controls... - Genome-wide analysis shows increased frequency of copy number variation deletions in Dutch schizophrenia patientsJacobine E Buizer-Voskamp
Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, Utrecht, The Netherlands
Biol Psychiatry 70:655-62. 2011.... - The influence of informant characteristics on the reliability of family history interviewsKim H W Verweij
Department of Psychiatry, Rudolf Magnus Institute of Neuroscience, University Medical Centre Utrecht, The Netherlands
Twin Res Hum Genet 14:217-20. 2011..In addition, psychiatric status of the informant should be carefully addressed... - Neuronal substrate of the saccadic inhibition deficit in schizophrenia investigated with 3-dimensional event-related functional magnetic resonance imagingMathijs Raemaekers
Department of Psychiatry, University Medical Center Utrecht, Utrecht, The Netherlands
Arch Gen Psychiatry 59:313-20. 2002..The results indicate that abnormalities in this network, rather than the selective dysfunction of prefrontal brain regions, underlie the saccade inhibition deficit in schizophrenia... - Transcranial magnetic stimulation of left auditory cortex in patients with schizophrenia: effects on hallucinations and neurocognitionAlfredo A L d'Alfonso
Psychological Laboratory, Utrecht University, The Netherlands
J Neuropsychiatry Clin Neurosci 14:77-9. 2002..A statistically significant improvement was observed on a hallucination scale after 10 days of TMS at the left auditory cortex... - Exploring the nature of facial affect processing deficits in schizophreniaMascha van 't Wout
Helmholtz Institute, Experimental Psychology, Utrecht University, Heidelberglaan 2, 3584 CS, Utrecht, The Netherlands
Psychiatry Res 150:227-35. 2007.... - Caregiver burden in recent-onset schizophrenia and spectrum disorders: the influence of symptoms and personality traitsJiska E D Wolthaus
Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
J Nerv Ment Dis 190:241-7. 2002..These findings suggest that psychoeducational programs should address the severity of disorganization symptoms to reduce caregiver burden in the early phase of schizophrenia... - Recurrent CNVs disrupt three candidate genes in schizophrenia patientsTerry Vrijenhoek
Department of Human Genetics, Radboud University Nijmegen Medical Centre, 6500 HB Nijmegen, The Netherlands
Am J Hum Genet 83:504-10. 2008..Our study supports a role for rare CNVs in schizophrenia susceptibility and identifies at least three candidate genes for this complex disorder...