Wiepke Cahn

Summary

Affiliation: University Medical Center
Country: The Netherlands

Publications

  1. ncbi Brain volume changes in first-episode schizophrenia: a 1-year follow-up study
    Wiepke Cahn
    Department of Psychiatry, University Medical Center Utrecht, Heidelberglaan 100, 3584 CX Utrecht, The Netherlands
    Arch Gen Psychiatry 59:1002-10. 2002
  2. doi Exercise therapy, cardiorespiratory fitness and their effect on brain volumes: a randomised controlled trial in patients with schizophrenia and healthy controls
    Thomas W Scheewe
    Rudolf Magnus Institute of Neuroscience, Department of Psychiatry, University Medical Center Utrecht, Utrecht, The Netherlands
    Eur Neuropsychopharmacol 23:675-85. 2013
  3. pmc Tract-based analysis of magnetization transfer ratio and diffusion tensor imaging of the frontal and frontotemporal connections in schizophrenia
    Rene C W Mandl
    Department of Psychiatry, Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, Heidelberglaan 100, 3584 CX Utrecht, The Netherlands
    Schizophr Bull 36:778-87. 2010
  4. doi Changes in cortical thickness during the course of illness in schizophrenia
    Neeltje E M van Haren
    Rudolf Magnus Institute of Neuroscience, Department of Psychiatry, University Medical Center Utrecht, Heidelberglaan, The Netherlands
    Arch Gen Psychiatry 68:871-80. 2011
  5. pmc Focal and global brain measurements in siblings of patients with schizophrenia
    Heleen B M Boos
    Rudolf Magnus Institute of Neuroscience, Department of Psychiatry, University Medical Center Utrecht, The Netherlands
    Schizophr Bull 38:814-25. 2012
  6. doi Differences in craving for cannabis between schizophrenia patients using risperidone, olanzapine or clozapine
    Marise Machielsen
    Department of Psychiatry, Academic Medical Centre, Amsterdam, The Netherlands
    J Psychopharmacol 26:189-95. 2012
  7. doi Classification of schizophrenia patients and healthy controls from structural MRI scans in two large independent samples
    Mireille Nieuwenhuis
    Department of Psychiatry, Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, P O Box 85500 3508 GA Utrecht, The Netherlands
    Neuroimage 61:606-12. 2012
  8. doi Cannabis use and progressive cortical thickness loss in areas rich in CB1 receptors during the first five years of schizophrenia
    Monica Rais
    Rudolf Magnus Institute of Neuroscience, Department of Psychiatry, University Medical Center Utrecht, Utrecht, The Netherlands
    Eur Neuropsychopharmacol 20:855-65. 2010
  9. doi Duration of untreated illness in schizophrenia is not associated with 5-year brain volume change
    Geartsje Boonstra
    Department of Psychiatry, University Medical Center Utrecht, P B 85500, 3508 GA, Utrecht, The Netherlands
    Schizophr Res 132:84-90. 2011
  10. ncbi Focal gray matter changes in schizophrenia across the course of the illness: a 5-year follow-up study
    Neeltje E M van Haren
    Department of Psychiatry, Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, Utrecht, The Netherlands
    Neuropsychopharmacology 32:2057-66. 2007

Detail Information

Publications41

  1. ncbi Brain volume changes in first-episode schizophrenia: a 1-year follow-up study
    Wiepke Cahn
    Department of Psychiatry, University Medical Center Utrecht, Heidelberglaan 100, 3584 CX Utrecht, The Netherlands
    Arch Gen Psychiatry 59:1002-10. 2002
    ..One would expect global gray matter to decrease progressively, particularly in first-episode patients, because clinical deterioration is greatest in the early stages of the disease...
  2. doi Exercise therapy, cardiorespiratory fitness and their effect on brain volumes: a randomised controlled trial in patients with schizophrenia and healthy controls
    Thomas W Scheewe
    Rudolf Magnus Institute of Neuroscience, Department of Psychiatry, University Medical Center Utrecht, Utrecht, The Netherlands
    Eur Neuropsychopharmacol 23:675-85. 2013
    ..However, cardiorespiratory fitness improvement attenuated brain volume changes in schizophrenia patients and increased thickness in large areas of the left cortex in both schizophrenia patients and healthy controls...
  3. pmc Tract-based analysis of magnetization transfer ratio and diffusion tensor imaging of the frontal and frontotemporal connections in schizophrenia
    Rene C W Mandl
    Department of Psychiatry, Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, Heidelberglaan 100, 3584 CX Utrecht, The Netherlands
    Schizophr Bull 36:778-87. 2010
    ..Focal reductions in myelin have been suggested in patients using magnetization transfer ratio (MTR) imaging but to what extent schizophrenia may be related to changes in MTR measured along entire fiber bundles is still unknown...
  4. doi Changes in cortical thickness during the course of illness in schizophrenia
    Neeltje E M van Haren
    Rudolf Magnus Institute of Neuroscience, Department of Psychiatry, University Medical Center Utrecht, Heidelberglaan, The Netherlands
    Arch Gen Psychiatry 68:871-80. 2011
    ..Whether cortical thickness changes in schizophrenia over time are more pronounced relative to the changes that can be attributed to normal aging has not been studied...
  5. pmc Focal and global brain measurements in siblings of patients with schizophrenia
    Heleen B M Boos
    Rudolf Magnus Institute of Neuroscience, Department of Psychiatry, University Medical Center Utrecht, The Netherlands
    Schizophr Bull 38:814-25. 2012
    ..This large magnetic resonance imaging study examined brain structures in patients with schizophrenia, their nonpsychotic siblings, and healthy control subjects using global and focal brain measurements...
  6. doi Differences in craving for cannabis between schizophrenia patients using risperidone, olanzapine or clozapine
    Marise Machielsen
    Department of Psychiatry, Academic Medical Centre, Amsterdam, The Netherlands
    J Psychopharmacol 26:189-95. 2012
    ..Risperidone and clozapine show a maximal difference in D(2) receptor occupancy rate, dissociation rate and D(1)/D(2) ratio. Olanzapine is intermediate between risperidone and clozapine in these characteristics...
  7. doi Classification of schizophrenia patients and healthy controls from structural MRI scans in two large independent samples
    Mireille Nieuwenhuis
    Department of Psychiatry, Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, P O Box 85500 3508 GA Utrecht, The Netherlands
    Neuroimage 61:606-12. 2012
    ..Larger training samples gave more reliable models: Models based on sample sizes smaller than N=130 should be considered unstable and can even score below chance...
  8. doi Cannabis use and progressive cortical thickness loss in areas rich in CB1 receptors during the first five years of schizophrenia
    Monica Rais
    Rudolf Magnus Institute of Neuroscience, Department of Psychiatry, University Medical Center Utrecht, Utrecht, The Netherlands
    Eur Neuropsychopharmacol 20:855-65. 2010
    ..First-episode schizophrenia patients who use cannabis show a more pronounced cortical thinning than non-using patients in areas known for their high density of CB1 receptors, such as the ACC and the DLPFC...
  9. doi Duration of untreated illness in schizophrenia is not associated with 5-year brain volume change
    Geartsje Boonstra
    Department of Psychiatry, University Medical Center Utrecht, P B 85500, 3508 GA, Utrecht, The Netherlands
    Schizophr Res 132:84-90. 2011
    ..We aimed to investigate the relationship between DUI, outcome and brain volume at illness onset or brain volume change during the first five years of the illness in first-episode patients...
  10. ncbi Focal gray matter changes in schizophrenia across the course of the illness: a 5-year follow-up study
    Neeltje E M van Haren
    Department of Psychiatry, Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, Utrecht, The Netherlands
    Neuropsychopharmacology 32:2057-66. 2007
    ..Moreover, the progression in left frontal density loss appears to be related to an increased number of psychotic episodes, with atypical antipsychotic medication attenuating these changes...
  11. doi Hippocampal volume change in schizophrenia
    P Cédric M P Koolschijn
    Rudolf Magnus Institute of Neuroscience, Department of Psychiatry, A 01 126, University Medical Center Utrecht, PO Box 85060, 3584 CX Utrecht, The Netherlands
    J Clin Psychiatry 71:737-44. 2010
    ..The aim of this study is to examine the extent to which hippocampal volume change in patients with schizophrenia is confounded by effects of age and/or antipsychotic medication...
  12. doi Tract-based diffusion tensor imaging in patients with schizophrenia and their non-psychotic siblings
    Heleen B M Boos
    Rudolf Magnus Institute of Neuroscience, Department of Psychiatry, University Medical Center Utrecht, Heidelberglaan 100, 3584 CX Utrecht, The Netherlands
    Eur Neuropsychopharmacol 23:295-304. 2013
    ..However, changes in the arcuate fasciculus may be relevant to (the risk to develop) psychosis, while a general and widespread loss of fiber integrity may be related to illness progression...
  13. doi Abnormal rich club organization and functional brain dynamics in schizophrenia
    Martijn P van den Heuvel
    Department of Psychiatry, Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, Utrecht, The Netherlands
    JAMA Psychiatry 70:783-92. 2013
    ..Abnormal brain connectivity may have a key role in the pathophysiology of schizophrenia...
  14. pmc Expression QTL analysis of top loci from GWAS meta-analysis highlights additional schizophrenia candidate genes
    Simone de Jong
    Department of Medical Genetics, University Medical Center Utrecht, Utrecht, The Netherlands
    Eur J Hum Genet 20:1004-8. 2012
    ..Our results identify new genes of interest and highlight again the involvement of the MHC region in schizophrenia susceptibility...
  15. ncbi Progressive brain volume loss in schizophrenia over the course of the illness: evidence of maturational abnormalities in early adulthood
    Neeltje E M van Haren
    Department of Psychiatry, Rudolf Magnus Institute of Neuroscience, University Medical Center, Utrecht, The Netherlands
    Biol Psychiatry 63:106-13. 2008
    ..Thus, one would expect the progression in brain volume change in schizophrenia to follow a more complex trajectory over time...
  16. doi Excessive brain volume loss over time in cannabis-using first-episode schizophrenia patients
    Monica Rais
    Department of Psychiatry, University Medical Center Utrecht, Heidelberglaan 100, 3584CX Utrecht, The Netherlands
    Am J Psychiatry 165:490-6. 2008
    ..Progressive gray matter changes in patients who use cannabis may be more extensive than in those who do not...
  17. doi Altered white matter connectivity in never-medicated patients with schizophrenia
    Rene C W Mandl
    Rudolf Magnus Institute of Neuroscience, Department of Psychiatry, University Medical Center Utrecht, Heidelberglaan 100, Utrecht, The Netherlands
    Hum Brain Mapp 34:2353-65. 2013
    ..We interpret these group-related differences as disease-related axonal or glial aberrations that cannot be attributed to antipsychotic medication use...
  18. doi Association study of copy number variants with brain volume in schizophrenia patients and healthy controls
    Afke Terwisscha van Scheltinga
    Department of Psychiatry, Rudolf Magnus Institute of Neuroscience, University Medical Centre Utrecht, Huispostnummer A00 241, Heidelberglaan 100, 3584 CX, Utrecht, The Netherlands
    Psychiatry Res 200:1011-3. 2012
    ..Although this could suggest a causal relationship, we found no association between global CNV burden and three brain volume measures (on a MRI scan) in a sample of 173 schizophrenia patients and 176 healthy controls...
  19. ncbi Brain volumes in relatives of patients with schizophrenia: a meta-analysis
    Heleen B M Boos
    Department of Psychiatry, Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, 3508 GA Utrecht, The Netherlands
    Arch Gen Psychiatry 64:297-304. 2007
    ..Although several studies have investigated brain volumes in nonpsychotic relatives of patients with schizophrenia, results have been inconsistent...
  20. ncbi Brain volumes as predictor of outcome in recent-onset schizophrenia: a multi-center MRI study
    Neeltje E M van Haren
    Department of Psychiatry A 01 126, University Medical Center Utrecht, 3584 CX Utrecht, The Netherlands
    Schizophr Res 64:41-52. 2003
    ..No significant correlations were found between the brain volume measures and any of these measures. Gray matter volume at illness onset does not predict outcome after 2 years in recent-onset schizophrenia...
  21. doi Brain volume changes after withdrawal of atypical antipsychotics in patients with first-episode schizophrenia
    Geartsje Boonstra
    Department of Psychiatry, Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, The Netherlands
    J Clin Psychopharmacol 31:146-53. 2011
    ..We found evidence suggestive of decreasing volumes of the putamen and nucleus accumbens over time after discontinuation of medication. This might suggest that discontinuation reverses effects of atypical medication...
  22. pmc Brain volumes in schizophrenia: a meta-analysis in over 18 000 subjects
    Sander V Haijma
    Department of Psychiatry, University Medical Center Utrecht, Utrecht, Netherlands
    Schizophr Bull 39:1129-38. 2013
    ..Therefore, brain loss in schizophrenia is related to a combination of (early) neurodevelopmental processes-reflected in intracranial volume reduction-as well as illness progression. ..
  23. doi Family-wise automatic classification in schizophrenia
    Rene C W Mandl
    Department of Psychiatry, University Medical Center Utrecht, Rudolf Magnus Institute of Neuroscience, The Netherlands
    Schizophr Res 149:108-11. 2013
    ..54 to 0.72 using a support vector machine model. This inclusion of contextual information is especially useful in diseases where the classification features carry a heritable component. ..
  24. ncbi Predictive value of cognition for different domains of outcome in recent-onset schizophrenia
    Esther A E Holthausen
    University Medical Center Groningen, Department of Psychiatry, P O Box 30 001, 9700 RB Groningen, The Netherlands
    Psychiatry Res 149:71-80. 2007
    ..It seems that cognition most strongly predicts work performance, where having a cognitive deficit, regardless of the nature of the deficit, acts as a rate-limiting factor...
  25. doi More prolonged brain activity related to gaze cueing in schizophrenia
    Maurice J C M Magnée
    Rudolf Magnus Institute of Neuroscience, Department of Child and Adolescent Psychiatry, University Medical Center, Heidelberglaan 100, 3584 CX Utrecht, The Netherlands
    Clin Neurophysiol 122:506-11. 2011
    ..Event Related Potentials (ERPs) can very accurately pinpoint the shifting of attention, and can therefore shed more light on cueing abilities in schizophrenia...
  26. doi Microglia activation in recent-onset schizophrenia: a quantitative (R)-[11C]PK11195 positron emission tomography study
    Bart N Van Berckel
    Department of Psychiatry, Rudolf Magnus Institute for Neuroscience, University Medical Center Utrecht, Utrecht, The Netherlands
    Biol Psychiatry 64:820-2. 2008
    ..Microglia activation can be quantified in vivo using (R)-[(11)C]PK11195 and positron emission tomography (PET). The purpose of this study was to investigate whether microglia activation occurs in patients with recent-onset schizophrenia...
  27. ncbi Verbal memory in first-episode schizophrenia: heterogeneity in performance?
    Jasper Nuyen
    Rudolf Magnus Institute of Neuroscience, Department of Psychiatry, University Medical Center, Utrecht, The Netherlands
    J Int Neuropsychol Soc 11:152-62. 2005
    ..Our results may suggest that combining the verbal memory performance of first-episode patients obscures meaningful heterogeneity. Alternatively, the cluster solution could merely reflect a continuum of severity...
  28. doi Cerebrospinal fluid D-serine and glycine concentrations are unaltered and unaffected by olanzapine therapy in male schizophrenic patients
    Sabine A Fuchs
    Department of Metabolic and Endocrine Diseases and Department of Biomedical Genetics, University Medical Center Utrecht, Utrecht, The Netherlands
    Eur Neuropsychopharmacol 18:333-8. 2008
    ....
  29. pmc Impaired rich club connectivity in unaffected siblings of schizophrenia patients
    Guusje Collin
    To whom correspondence should be addressed Department of Psychiatry, University Medical Center Utrecht, Rudolf Magnus Institute of Neuroscience, PO Box 85500, Heidelberglaan 100, 3508 GA Utrecht, The Netherlands tel 31 88 75 58161, fax 31 88 75 55443, E mail
    Schizophr Bull 40:438-48. 2014
    ..Our findings support a central role for abnormal rich club organization in the etiology of schizophrenia. ..
  30. pmc A gene co-expression network in whole blood of schizophrenia patients is independent of antipsychotic-use and enriched for brain-expressed genes
    Simone de Jong
    Department of Medical Genetics, University Medical Center Utrecht, Utrecht, The Netherlands
    PLoS ONE 7:e39498. 2012
    ..This suggests that the MHC increases schizophrenia susceptibility via altered gene expression of regulatory genes in this network...
  31. ncbi Fluorescence of neutrophil granulocytes as a biomarker for clozapine use
    Wai Hong Man
    Department of Clinical Pharmacy, University Medical Center Utrecht, The Netherlands
    Eur Neuropsychopharmacol 23:1408-13. 2013
    ..Further research is needed to unravel the underlying mechanism and to investigate the true potential of FL3-fluorescence as a clozapine-adherence biomarker in clinical practice. ..
  32. doi Open, randomized trial of the effects of aripiprazole versus risperidone on social cognition in schizophrenia
    Arija Maat
    Department of Psychiatry, Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, Huispostnummer A 00 241, Postbus 85500, 3508 GA Utrecht, Utrecht, The Netherlands Electronic address
    Eur Neuropsychopharmacol 24:575-84. 2014
    ..Further research on the long-term effects of aripiprazole on cognition is warranted. ..
  33. ncbi Neuronal substrate of the saccadic inhibition deficit in schizophrenia investigated with 3-dimensional event-related functional magnetic resonance imaging
    Mathijs Raemaekers
    Department of Psychiatry, University Medical Center Utrecht, Utrecht, The Netherlands
    Arch Gen Psychiatry 59:313-20. 2002
    ..Functional localization of the affected brain structure(s) potentially provides a physiological measure for the investigation of vulnerability markers in schizophrenia...
  34. doi Effects of exercise therapy on cardiorespiratory fitness in patients with schizophrenia
    Thomas W Scheewe
    Department of Psychiatry, Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, Utrecht, The Netherlands
    Med Sci Sports Exerc 44:1834-42. 2012
    ..We compared CRF in patients with schizophrenia to CRF of matched healthy controls and reference values. Also, we examined the effects of exercise therapy on CRF in patients with schizophrenia and in controls...
  35. pmc Genome-wide analysis shows increased frequency of copy number variation deletions in Dutch schizophrenia patients
    Jacobine E Buizer-Voskamp
    Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, Utrecht, The Netherlands
    Biol Psychiatry 70:655-62. 2011
    ....
  36. doi The influence of informant characteristics on the reliability of family history interviews
    Kim H W Verweij
    Department of Psychiatry, Rudolf Magnus Institute of Neuroscience, University Medical Centre Utrecht, The Netherlands
    Twin Res Hum Genet 14:217-20. 2011
    ..In addition, psychiatric status of the informant should be carefully addressed...
  37. ncbi Transcranial magnetic stimulation of left auditory cortex in patients with schizophrenia: effects on hallucinations and neurocognition
    Alfredo A L d'Alfonso
    Psychological Laboratory, Utrecht University, The Netherlands
    J Neuropsychiatry Clin Neurosci 14:77-9. 2002
    ..A statistically significant improvement was observed on a hallucination scale after 10 days of TMS at the left auditory cortex...
  38. ncbi Caregiver burden in recent-onset schizophrenia and spectrum disorders: the influence of symptoms and personality traits
    Jiska E D Wolthaus
    Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    J Nerv Ment Dis 190:241-7. 2002
    ..These findings suggest that psychoeducational programs should address the severity of disorganization symptoms to reduce caregiver burden in the early phase of schizophrenia...
  39. ncbi Exploring the nature of facial affect processing deficits in schizophrenia
    Mascha van 't Wout
    Helmholtz Institute, Experimental Psychology, Utrecht University, Heidelberglaan 2, 3584 CS, Utrecht, The Netherlands
    Psychiatry Res 150:227-35. 2007
    ....
  40. pmc Recurrent CNVs disrupt three candidate genes in schizophrenia patients
    Terry Vrijenhoek
    Department of Human Genetics, Radboud University Nijmegen Medical Centre, 6500 HB Nijmegen, The Netherlands
    Am J Hum Genet 83:504-10. 2008
    ..Our study supports a role for rare CNVs in schizophrenia susceptibility and identifies at least three candidate genes for this complex disorder...