- Mdm2 induces mono-ubiquitination of FOXO4Arjan B Brenkman
Department of Physiological Chemistry and Centre for Biomedical Genetics, University Medical Centre Utrecht, Utrecht, The Netherlands
PLoS ONE 3:e2819. 2008..For example, the de-ubiquitinating enzyme USP7 removes ubiquitin from both FOXO and p53. However, Skp2 has been identified as E3 ligase for FOXO1, whereas Mdm2 is the prime E3 ligase for p53...
- Genome-wide analysis of FOXO3 mediated transcription regulation through RNA polymerase II profilingAstrid Eijkelenboom
Department of Molecular Cancer Research, University Medical Centre, Utrecht, The Netherlands
Mol Syst Biol 9:638. 2013..Combined, our data elucidate how FOXOs regulate gene transcription and provide insight into mechanisms by which FOXOs can induce different gene expression programs depending on chromatin architecture...
- A brief introduction to FOXOlogyB M Th Burgering
Laboratory of Physiological Chemistry, University Medical Center Utrecht, Stratenum, Utrecht, The Netherlands
Oncogene 27:2258-62. 2008..With this perspective, further studies on FOXO function and regulation may shed light on how age impacts on the onset and progression of disease...