J Peter H Burbach

Summary

Affiliation: University Medical Center Utrecht
Country: The Netherlands

Publications

  1. doi Contact in the genetics of autism and schizophrenia
    J Peter H Burbach
    Rudolf Magnus Institute of Neuroscience, Department of Neuroscience and Pharmacology, University Medical Center Utrecht, P O Box 85060, 3508 AB Utrecht, The Netherlands
    Trends Neurosci 32:69-72. 2009
  2. pmc The transcription factor Uncx4.1 acts in a short window of midbrain dopaminergic neuron differentiation
    Tamara I Rabe
    Department of Molecular Cell Biology, Max Planck Institute of Biophysical Chemistry, Am Fassberg 11, Goettingen, 37077, Germany
    Neural Dev 7:39. 2012
  3. doi What are neuropeptides?
    J Peter H Burbach
    Rudolf Magnus Institute of Neuroscience, Department of Neuroscience and Pharmacology, University Medical Center Utrecht, Utrecht, The Netherlands
    Methods Mol Biol 789:1-36. 2011
  4. doi Neuropeptides from concept to online database www.neuropeptides.nl
    J Peter H Burbach
    Rudolf Magnus Institute of Neuroscience, Department of Neuroscience and Pharmacology, University Medical Center Utrecht, AB Utrecht, The Netherlands
    Eur J Pharmacol 626:27-48. 2010
  5. doi Retinoic acid-dependent and -independent gene-regulatory pathways of Pitx3 in meso-diencephalic dopaminergic neurons
    Frank M J Jacobs
    Rudolf Magnus Institute, Department of Neuroscience and Pharmacology, UMC Utrecht, Utrecht, The Netherlands
    Development 138:5213-22. 2011
  6. doi Pitx3 potentiates Nurr1 in dopamine neuron terminal differentiation through release of SMRT-mediated repression
    Frank M J Jacobs
    Department of Neuroscience and Pharmacology, University Medical Center Utrecht, Universiteitsweg 100, 3584 CG, Utrecht, The Netherlands
    Development 136:531-40. 2009
  7. ncbi Early developmental failure of substantia nigra dopamine neurons in mice lacking the homeodomain gene Pitx3
    Marten P Smidt
    Rudolf Magnus Institute of Neuroscience, Department of Pharmacology and Anatomy, University Medical Center, Universiteitsweg 100, 3584 CG Utrecht, The Netherlands
    Development 131:1145-55. 2004
  8. pmc Identification of Dlk1, Ptpru and Klhl1 as novel Nurr1 target genes in meso-diencephalic dopamine neurons
    Frank M J Jacobs
    Rudolf Magnus Institute of Neuroscience, Department of Neuroscience and Pharmacology, University Medical Center Utrecht, Universiteitsweg 100, 3584 CG, Utrecht, The Netherlands
    Development 136:2363-73. 2009
  9. ncbi Retinoic acid counteracts developmental defects in the substantia nigra caused by Pitx3 deficiency
    Frank M J Jacobs
    Rudolf Magnus Institute of Neuroscience, Department of Pharmacology and Anatomy, University Medical Center Utrecht, Universiteitsweg 100, 3584 CG Utrecht, The Netherlands
    Development 134:2673-84. 2007
  10. ncbi Identification of forkhead transcription factors in cortical and dopaminergic areas of the adult murine brain
    Patrick J E C Wijchers
    Rudolf Magnus Institute of Neuroscience, Department of Pharmacology and Anatomy, University Medical Center Utrecht, Universiteitsweg 100, 3584 CG Utrecht, The Netherlands
    Brain Res 1068:23-33. 2006

Collaborators

Detail Information

Publications43

  1. doi Contact in the genetics of autism and schizophrenia
    J Peter H Burbach
    Rudolf Magnus Institute of Neuroscience, Department of Neuroscience and Pharmacology, University Medical Center Utrecht, P O Box 85060, 3508 AB Utrecht, The Netherlands
    Trends Neurosci 32:69-72. 2009
    ..These findings raise the possibility that these neuropsychiatric disorders share pathogenic mechanisms and that similar defects in biological pathways of brain development might underlie the phenotypic spectrum of these disorders...
  2. pmc The transcription factor Uncx4.1 acts in a short window of midbrain dopaminergic neuron differentiation
    Tamara I Rabe
    Department of Molecular Cell Biology, Max Planck Institute of Biophysical Chemistry, Am Fassberg 11, Goettingen, 37077, Germany
    Neural Dev 7:39. 2012
    ..The goal of the current study was to analyze in which midbrain neuronal subgroups Uncx4.1 is expressed and to examine whether this factor plays a role in the early development of these neuronal subgroups...
  3. doi What are neuropeptides?
    J Peter H Burbach
    Rudolf Magnus Institute of Neuroscience, Department of Neuroscience and Pharmacology, University Medical Center Utrecht, Utrecht, The Netherlands
    Methods Mol Biol 789:1-36. 2011
    ..All classical neuropeptides as well as putative neuropeptides from the latter families are presented as a resource...
  4. doi Neuropeptides from concept to online database www.neuropeptides.nl
    J Peter H Burbach
    Rudolf Magnus Institute of Neuroscience, Department of Neuroscience and Pharmacology, University Medical Center Utrecht, AB Utrecht, The Netherlands
    Eur J Pharmacol 626:27-48. 2010
    ....
  5. doi Retinoic acid-dependent and -independent gene-regulatory pathways of Pitx3 in meso-diencephalic dopaminergic neurons
    Frank M J Jacobs
    Rudolf Magnus Institute, Department of Neuroscience and Pharmacology, UMC Utrecht, Utrecht, The Netherlands
    Development 138:5213-22. 2011
    ..In conclusion, our data reveal several RA-dependent and -independent aspects of the Pitx3-regulated gene cascade, suggesting that Pitx3 acts on multiple levels in the molecular subset-specification of mdDA neurons...
  6. doi Pitx3 potentiates Nurr1 in dopamine neuron terminal differentiation through release of SMRT-mediated repression
    Frank M J Jacobs
    Department of Neuroscience and Pharmacology, University Medical Center Utrecht, Universiteitsweg 100, 3584 CG, Utrecht, The Netherlands
    Development 136:531-40. 2009
    ....
  7. ncbi Early developmental failure of substantia nigra dopamine neurons in mice lacking the homeodomain gene Pitx3
    Marten P Smidt
    Rudolf Magnus Institute of Neuroscience, Department of Pharmacology and Anatomy, University Medical Center, Universiteitsweg 100, 3584 CG Utrecht, The Netherlands
    Development 131:1145-55. 2004
    ..However, an overall lower activity was observed. The results suggest that Pitx3 is specifically required for the formation of the SNc subfield at the onset of dopaminergic neuron differentiation...
  8. pmc Identification of Dlk1, Ptpru and Klhl1 as novel Nurr1 target genes in meso-diencephalic dopamine neurons
    Frank M J Jacobs
    Rudolf Magnus Institute of Neuroscience, Department of Neuroscience and Pharmacology, University Medical Center Utrecht, Universiteitsweg 100, 3584 CG, Utrecht, The Netherlands
    Development 136:2363-73. 2009
    ....
  9. ncbi Retinoic acid counteracts developmental defects in the substantia nigra caused by Pitx3 deficiency
    Frank M J Jacobs
    Rudolf Magnus Institute of Neuroscience, Department of Pharmacology and Anatomy, University Medical Center Utrecht, Universiteitsweg 100, 3584 CG Utrecht, The Netherlands
    Development 134:2673-84. 2007
    ..Here, we propose a novel mechanism in which RA is involved in mdDA neuronal development and maintenance, providing new insights into subset-specific vulnerability in PD...
  10. ncbi Identification of forkhead transcription factors in cortical and dopaminergic areas of the adult murine brain
    Patrick J E C Wijchers
    Rudolf Magnus Institute of Neuroscience, Department of Pharmacology and Anatomy, University Medical Center Utrecht, Universiteitsweg 100, 3584 CG Utrecht, The Netherlands
    Brain Res 1068:23-33. 2006
    ..These forkhead transcription factors may play a role in maintenance and survival of developing and adult neurons...
  11. ncbi Developmental origin and fate of meso-diencephalic dopamine neurons
    Simone M Smits
    Rudolf Magnus Institute of Neuroscience, Department of Pharmacology and Anatomy, University Medical Center Utrecht, Universiteitsweg 100, 3584 CG Utrecht, The Netherlands
    Prog Neurobiol 78:1-16. 2006
    ..The data indicate that these specific subsets may explain the specific response of these neurons to toxins and genetic ablation...
  12. pmc Semaphorin 3F is a bifunctional guidance cue for dopaminergic axons and controls their fasciculation, channeling, rostral growth, and intracortical targeting
    Sharon M Kolk
    Department of Neuroscience and Pharmacology, Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, 3584 CG Utrecht, The Netherlands
    J Neurosci 29:12542-57. 2009
    ..In all, this study provides a framework for additional dissection of the molecular basis of mdDA pathway development and disease...
  13. ncbi Involvement of Nurr1 in specifying the neurotransmitter identity of ventral midbrain dopaminergic neurons
    Simone M Smits
    Rudolf Magnus Institute of Neuroscience, Department of Pharmacology and Anatomy, University Medical Center Utrecht, Universiteitsweg 100, 3584 CG Utrecht, The Netherlands
    Eur J Neurosci 18:1731-8. 2003
    ..5 and 14.5. Here we demonstrate that induction of VMAT2 and DAT specifically in mesDA neurons requires Nurr1 expression, whereas AADC expression in mesDA neurons is induced independently of Nurr1 function...
  14. ncbi Molecular and cellular alterations in the Pitx3-deficient midbrain dopaminergic system
    Simone M Smits
    Rudolf Magnus Institute of Neuroscience, Department of Pharmacology and Anatomy, University Medical Center Utrecht, Universiteitsweg 100, 3584 CG Utrecht, The Netherlands
    Mol Cell Neurosci 30:352-63. 2005
    ..In conclusion, ak mice display specific molecular and cellular alterations in the mDA system that provide new insights in compensatory mechanisms present in mDA-associated disorders such as PD...
  15. pmc FoxO6 transcriptional activity is regulated by Thr26 and Ser184, independent of nucleo-cytoplasmic shuttling
    Lars P van der Heide
    Rudolf Magnus Institute of Neuroscience, Department of Pharmacology and Anatomy, University Medical Center Utrecht, Universiteitsweg 100, 3584 CG Utrecht, The Netherlands
    Biochem J 391:623-9. 2005
    ..In summary, FoxO6 is not a constitutively active transcription factor and can be regulated by growth factors in a Thr26- and Ser184-dependent manner, independent of shuttling to the cytosol...
  16. ncbi Spatial and temporal expression of FoxO transcription factors in the developing and adult murine brain
    Marco F M Hoekman
    Department of Pharmacology and Anatomy, Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, Universiteitsweg 100, 3584 CG Utrecht, The Netherlands
    Gene Expr Patterns 6:134-40. 2006
    ..5 and E14. In summary, the presented data show FoxO factors to be expressed in the adult and developing mouse brain, in a spatially end temporally restricted manner...
  17. pmc A co-segregating microduplication of chromosome 15q11.2 pinpoints two risk genes for autism spectrum disorder
    Bert van der Zwaag
    Department of Neuroscience and Pharmacology, Rudolf Magnus Institute of Neuroscience, UMC Utrecht, Utrecht, The Netherlands
    Am J Med Genet B Neuropsychiatr Genet 153:960-6. 2010
    ..247), which suggests that our findings should be interpreted with caution and indicates the need for studies that include large numbers of control subjects to ascertain the impact of these changes on a population scale...
  18. ncbi Sciatic nerve regeneration in mice and rats: recovery of sensory innervation is followed by a slowly retreating neuropathic pain-like syndrome
    Christina F Vogelaar
    Rudolf Magnus Institute of Neuroscience, Department of Pharmacology and Anatomy, Universiteitsweg 100, 3584 CG Utrecht, The Netherlands
    Brain Res 1027:67-72. 2004
    ..The development of neuropathic pain following successful sensory recovery has not been described before in crush-lesioned animals and may provide an important new parameter to assess full sensory recovery...
  19. ncbi The role of Munc18-1 in docking and exocytosis of peptide hormone vesicles in the anterior pituitary
    Niki Korteweg
    Molecular Neuroscience, Rudolf Magnus Institute, University of Utrecht, Utrecht, The Netherlands
    Biol Cell 97:445-55. 2005
    ..The soluble protein Munc18-1 is essential for synaptic vesicle secretion [Verhage, Maia, Plomp, Brussaard, Heeroma, Vermeer, Toonen, Hammer, van den Berg, Missler, et al. (2000) Science 287, 864-869.]...
  20. ncbi Homeobox gene Pitx3 and its role in the development of dopamine neurons of the substantia nigra
    Marten P Smidt
    Department of Pharmacology and Anatomy, Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, Universiteitsweg 100, 3584 CG, Utrecht, The Netherlands
    Cell Tissue Res 318:35-43. 2004
    ..Molecular analysis of the underlying mechanisms might provide new insights for understanding the selective degeneration observed in Parkinson patients...
  21. ncbi Molecular programming of stem cells into mesodiencephalic dopaminergic neurons
    J Peter H Burbach
    Rudolf Magnus Institute of Neuroscience, Department of Pharmacology and Anatomy, University Medical Center Utrecht, PO Box 85060, 3508 AB Utrecht, The Netherlands
    Trends Neurosci 29:601-3. 2006
    ..Lmx1a also initiated a developmental program that drove an mdDA phenotype in mouse embryonic stem cells. This indicates that these factors can be exploited in cell-replacement strategies for treatment of Parkinson's disease...
  22. pmc A passport to neurotransmitter identity
    Marten P Smidt
    Neuroscience and Pharmacology, University Medical Center Utrecht, Universiteitsweg 100, 3584 CG Utrecht, The Netherlands
    Genome Biol 10:229. 2009
    ..Comparison of a regulatory network that specifies dopaminergic neurons in Caenorhabditis elegans to the development of vertebrate dopamine systems in the mouse reveals a possible partial conservation of such a network...
  23. ncbi Species differences in brain pre-pro-neurotensin/neuromedin N mRNA distribution: the expression pattern in mice resembles more closely that of primates than rats
    Simone M Smits
    Rudolf Magnus Institute of Neuroscience, Department of Pharmacology and Anatomy, University Medical Center Utrecht, Universiteitsweg 100, 3584 CG, The Netherlands
    Brain Res Mol Brain Res 125:22-8. 2004
    ..Moreover, these data indicate that the distribution in mice resembles most that of primates than rats...
  24. ncbi Decreased thalamic expression of the homeobox gene DLX1 in psychosis
    Marjan Kromkamp
    Department of Pharmacology, Rudolf Magnus Institute for Neurosciences, University Medical Center, Utrecht, The Netherlands
    Arch Gen Psychiatry 60:869-74. 2003
    ..Homeobox genes involved in development and differentiation of the brain could play an important role in these disorders...
  25. ncbi Molecular mechanisms underlying midbrain dopamine neuron development and function
    Marten P Smidt
    Department of Pharmacology and Anatomy, Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, Universiteitsweg 100, 3584 CG, Utrecht, The Netherlands
    Eur J Pharmacol 480:75-88. 2003
    ..Finally, we analyse the potential of the mesencephalic dopaminergic system to adapt to gene dysfunction...
  26. pmc Social Responsiveness Scale-aided analysis of the clinical impact of copy number variations in autism
    Emma van Daalen
    Department of Child and Adolescent Psychiatry, University Medical Centre, Utrecht, The Netherlands
    Neurogenetics 12:315-23. 2011
    ..Our study extends the scope of genome-wide CNV profiling beyond de novo CNVs in sporadic patients and may aid in uncovering missing heritability in genome-wide screening studies of complex psychiatric disorders...
  27. ncbi Endogenous cannabinoids are not involved in cocaine reinforcement and development of cocaine-induced behavioural sensitization
    Heidi M B Lesscher
    Department of Pharmacology and Anatomy, Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, Stratenum, Universiteitsweg 100, 3584 CG Utrecht, The Netherlands
    Eur Neuropsychopharmacol 15:31-7. 2005
    ..These findings suggest that CB1 receptors are not involved in acute cocaine reinforcement nor in cocaine-induced behavioural sensitization...
  28. pmc Gene-network analysis identifies susceptibility genes related to glycobiology in autism
    Bert van der Zwaag
    Department of Neuroscience and Pharmacology, Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, Utrecht, The Netherlands
    PLoS ONE 4:e5324. 2009
    ..Our findings suggest that the occurrence of genomic gains and losses of genes associated with glycobiology are important contributors to the development of ASD...
  29. ncbi Transcription factors in the development of midbrain dopamine neurons
    J Peter H Burbach
    Rudolf Magnus Institute of Neuroscience, Department of Pharmacology and Anatomy, University Medical Center Utrecht, Utrecht, The Netherlands
    Ann N Y Acad Sci 991:61-8. 2003
    ....
  30. ncbi Development of the mouse hypothalamo-neurohypophysial system in the munc18-1 null mutant that lacks regulated secretion
    Niki Korteweg
    Rudolf Magnus Institute of Neuroscience, Department of Pharmacology and Anatomy, University Medical Centre Utrecht, Universiteitsweg 100, 3584 CG Utrecht, The Netherlands
    Eur J Neurosci 19:2944-52. 2004
    ..Thus, the communication between the outgrowing neurons and the pituicytes could serve to integrate these two cell types to constitute a functional peptidergic system...
  31. ncbi Cloning and analysis of the murine Foxi2 transcription factor
    Patrick J E C Wijchers
    Rudolf Magnus Institute of Neuroscience, Department of Pharmacology and Anatomy, University Medical Center Utrecht, Universiteitsweg 100, 3584 CG Utrecht, The Netherlands
    Biochim Biophys Acta 1731:133-8. 2005
    ..Since FoxI factors are thought to be implicated in the regulation of cell fate, the highly restricted expression pattern of Foxi2 suggestive of a possible role in controlling cellular identity...
  32. ncbi How to make a mesodiencephalic dopaminergic neuron
    Marten P Smidt
    Department of Pharmacology and Anatomy, Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, 3508 AB Utrecht corrected The Netherlands
    Nat Rev Neurosci 8:21-32. 2007
    ..Here, we follow the developmental path of these neurons with the goal of generating a molecular code that could be exploited in cell-replacement strategies to treat diseases such as Parkinson's disease...
  33. pmc In control of biology: of mice, men and Foxes
    Patrick J E C Wijchers
    Rudolf Magnus Institute of Neuroscience, Department of Pharmacology and Anatomy, University Medical Center Utrecht, Universiteitsweg 100, 3584 CG Utrecht, The Netherlands
    Biochem J 397:233-46. 2006
    ..Finally, we will discuss how novel insights gained from involvement of 'Foxes' in the mechanisms underlying human pathology may create new opportunities for treatment strategies...
  34. pmc Molecular marker differences relate to developmental position and subsets of mesodiencephalic dopaminergic neurons
    Simone M Smits
    Department of Neuroscience and Pharmacology, Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, Utrecht, The Netherlands
    PLoS ONE 8:e76037. 2013
    ..In the adult stage more of such subsets specific expressed genes are present and may represent a molecular map defining molecularly distinct groups of mdDA neurons. ..
  35. doi Copy-number variation in sporadic amyotrophic lateral sclerosis: a genome-wide screen
    Hylke M Blauw
    Department of Neurology, Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, Utrecht, Netherlands
    Lancet Neurol 7:319-26. 2008
    ....
  36. ncbi Homeobox gene expression in adult dorsal root ganglia during sciatic nerve regeneration: is regeneration a recapitulation of development?
    Christina F Vogelaar
    Department of Pharmacology and Anatomy, Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, Universiteitsweg 100, 3584 CG, Utrecht, The Netherlands
    Eur J Pharmacol 480:233-50. 2003
    ..This mechanism may be the basis of pharmacological strategies to stimulate regeneration...
  37. doi Contactins in the neurobiology of autism
    Amila Zuko
    Department of Neuroscience and Pharmacology, Brain Center Rudolf Magnus, UMC Medical Center Utrecht, 3584 CG Utrecht, The Netherlands
    Eur J Pharmacol 719:63-74. 2013
    ..A future task will be to establish if proposed pharmacological strategies to counteract ASD-related symptomes can also be applied to reversal of phenotypes caused by genetic defects in these CNTN genes. ..
  38. ncbi CNS expression pattern of Lmx1b and coexpression with ptx genes suggest functional cooperativity in the development of forebrain motor control systems
    Ceriel H J Asbreuk
    Rudolf Magnus Institute of Neuroscience, Department of Pharmacology and Anatomy, University Medical Center, Universiteitsweg 100, 3584 CG, Utrecht, The Netherlands
    Mol Cell Neurosci 21:410-20. 2002
    ..These data point to a combinatorial gene network that allows Lmx1b to diversify its regulatory actions by cooperation with specific Ptx genes...
  39. ncbi Mu-opioid receptors are not involved in acute cocaine-induced locomotor activity nor in development of cocaine-induced behavioral sensitization in mice
    Heidi M B Lesscher
    Department of Pharmacology and Anatomy, Rudolf Magnus Institute of Neuroscience, UMC Utrecht, Stratenum, Universiteitsweg 100, Utrecht, The Netherlands
    Neuropsychopharmacology 30:278-85. 2005
    ..The present findings suggest that mu-opioid receptors are not required for the acute locomotor response to cocaine nor are they essential for the development of cocaine-induced behavioral sensitization...
  40. ncbi U-SPECT-I: a novel system for submillimeter-resolution tomography with radiolabeled molecules in mice
    Freek J Beekman
    Department of Nuclear Medicine, Image Sciences Institute, University Medical Center Utrecht, Utrecht, The Netherlands
    J Nucl Med 46:1194-200. 2005
    ..Here, we present a SPECT system (U-SPECT-I) dedicated to radionuclide imaging of murine organs at a submillimeter resolution...
  41. ncbi FoxO6, a novel member of the FoxO class of transcription factors with distinct shuttling dynamics
    Frank M J Jacobs
    Rudolf Magnus Institute of Neuroscience, Department of Pharmacology and Anatomy, University Medical Center, Universiteitsweg 100, 3584 CG Utrecht, The Netherlands
    J Biol Chem 278:35959-67. 2003
    ..In conclusion, the data presented here gives a new view on regulation of FoxO-function through multiple phosphorylation events and other mechanisms involved in the nuclear exclusion of FoxO-proteins...
  42. ncbi Regulation of gene promoters of hypothalamic peptides
    J Peter H Burbach
    Department of Pharmacology, Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, Universiteitsweg 100, 3584 CG Utrecht, The Netherlands
    Front Neuroendocrinol 23:342-69. 2002
    ..Others are essential to provide cell-specific expression of the peptidergic gene during development and mature regulation...
  43. doi Contactins: structural aspects in relation to developmental functions in brain disease
    Amila Zuko
    Department of Neuroscience and Pharmacology, Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, Utrecht, The Netherlands
    Adv Protein Chem Struct Biol 84:143-80. 2011
    ..The present data indicate that Cntn4, -5, and -6 proteins may be part of heteromeric receptor complexes as well as serve as ligands themselves...