Research Topics
Genomes and Genes
| J Peter H BurbachSummaryAffiliation: University Medical Center Utrecht Country: The Netherlands Publications
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Detail Information
Publications
Contact in the genetics of autism and schizophreniaJ Peter H Burbach
Rudolf Magnus Institute of Neuroscience, Department of Neuroscience and Pharmacology, University Medical Center Utrecht, P O Box 85060, 3508 AB Utrecht, The Netherlands
Trends Neurosci 32:69-72. 2009..These findings raise the possibility that these neuropsychiatric disorders share pathogenic mechanisms and that similar defects in biological pathways of brain development might underlie the phenotypic spectrum of these disorders...- What are neuropeptides?J Peter H Burbach
Rudolf Magnus Institute of Neuroscience, Department of Neuroscience and Pharmacology, University Medical Center Utrecht, Utrecht, The Netherlands
Methods Mol Biol 789:1-36. 2011..All classical neuropeptides as well as putative neuropeptides from the latter families are presented as a resource... - Neuropeptides from concept to online database www.neuropeptides.nlJ Peter H Burbach
Rudolf Magnus Institute of Neuroscience, Department of Neuroscience and Pharmacology, University Medical Center Utrecht, AB Utrecht, The Netherlands
Eur J Pharmacol 626:27-48. 2010.... - Retinoic acid-dependent and -independent gene-regulatory pathways of Pitx3 in meso-diencephalic dopaminergic neuronsFrank M J Jacobs
Rudolf Magnus Institute, Department of Neuroscience and Pharmacology, UMC Utrecht, Utrecht, The Netherlands
Development 138:5213-22. 2011..In conclusion, our data reveal several RA-dependent and -independent aspects of the Pitx3-regulated gene cascade, suggesting that Pitx3 acts on multiple levels in the molecular subset-specification of mdDA neurons... 
Early developmental failure of substantia nigra dopamine neurons in mice lacking the homeodomain gene Pitx3Marten P Smidt
Rudolf Magnus Institute of Neuroscience, Department of Pharmacology and Anatomy, University Medical Center, Universiteitsweg 100, 3584 CG Utrecht, The Netherlands
Development 131:1145-55. 2004..However, an overall lower activity was observed. The results suggest that Pitx3 is specifically required for the formation of the SNc subfield at the onset of dopaminergic neuron differentiation...- Pitx3 potentiates Nurr1 in dopamine neuron terminal differentiation through release of SMRT-mediated repressionFrank M J Jacobs
Department of Neuroscience and Pharmacology, University Medical Center Utrecht, Universiteitsweg 100, 3584 CG, Utrecht, The Netherlands
Development 136:531-40. 2009.... 
Identification of Dlk1, Ptpru and Klhl1 as novel Nurr1 target genes in meso-diencephalic dopamine neuronsFrank M J Jacobs
Rudolf Magnus Institute of Neuroscience, Department of Neuroscience and Pharmacology, University Medical Center Utrecht, Universiteitsweg 100, 3584 CG, Utrecht, The Netherlands
Development 136:2363-73. 2009....- Retinoic acid counteracts developmental defects in the substantia nigra caused by Pitx3 deficiencyFrank M J Jacobs
Rudolf Magnus Institute of Neuroscience, Department of Pharmacology and Anatomy, University Medical Center Utrecht, Universiteitsweg 100, 3584 CG Utrecht, The Netherlands
Development 134:2673-84. 2007..Here, we propose a novel mechanism in which RA is involved in mdDA neuronal development and maintenance, providing new insights into subset-specific vulnerability in PD... - Identification of forkhead transcription factors in cortical and dopaminergic areas of the adult murine brainPatrick J E C Wijchers
Rudolf Magnus Institute of Neuroscience, Department of Pharmacology and Anatomy, University Medical Center Utrecht, Universiteitsweg 100, 3584 CG Utrecht, The Netherlands
Brain Res 1068:23-33. 2006..These forkhead transcription factors may play a role in maintenance and survival of developing and adult neurons... - Semaphorin 3F is a bifunctional guidance cue for dopaminergic axons and controls their fasciculation, channeling, rostral growth, and intracortical targetingSharon M Kolk
Department of Neuroscience and Pharmacology, Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, 3584 CG Utrecht, The Netherlands
J Neurosci 29:12542-57. 2009..In all, this study provides a framework for additional dissection of the molecular basis of mdDA pathway development and disease... - Involvement of Nurr1 in specifying the neurotransmitter identity of ventral midbrain dopaminergic neuronsSimone M Smits
Rudolf Magnus Institute of Neuroscience, Department of Pharmacology and Anatomy, University Medical Center Utrecht, Universiteitsweg 100, 3584 CG Utrecht, The Netherlands
Eur J Neurosci 18:1731-8. 2003..5 and 14.5. Here we demonstrate that induction of VMAT2 and DAT specifically in mesDA neurons requires Nurr1 expression, whereas AADC expression in mesDA neurons is induced independently of Nurr1 function... - Developmental origin and fate of meso-diencephalic dopamine neuronsSimone M Smits
Rudolf Magnus Institute of Neuroscience, Department of Pharmacology and Anatomy, University Medical Center Utrecht, Universiteitsweg 100, 3584 CG Utrecht, The Netherlands
Prog Neurobiol 78:1-16. 2006..The data indicate that these specific subsets may explain the specific response of these neurons to toxins and genetic ablation... - Molecular and cellular alterations in the Pitx3-deficient midbrain dopaminergic systemSimone M Smits
Rudolf Magnus Institute of Neuroscience, Department of Pharmacology and Anatomy, University Medical Center Utrecht, Universiteitsweg 100, 3584 CG Utrecht, The Netherlands
Mol Cell Neurosci 30:352-63. 2005..In conclusion, ak mice display specific molecular and cellular alterations in the mDA system that provide new insights in compensatory mechanisms present in mDA-associated disorders such as PD... - FoxO6 transcriptional activity is regulated by Thr26 and Ser184, independent of nucleo-cytoplasmic shuttlingLars P van der Heide
Rudolf Magnus Institute of Neuroscience, Department of Pharmacology and Anatomy, University Medical Center Utrecht, Universiteitsweg 100, 3584 CG Utrecht, The Netherlands
Biochem J 391:623-9. 2005..In summary, FoxO6 is not a constitutively active transcription factor and can be regulated by growth factors in a Thr26- and Ser184-dependent manner, independent of shuttling to the cytosol... - A co-segregating microduplication of chromosome 15q11.2 pinpoints two risk genes for autism spectrum disorderBert van der Zwaag
Department of Neuroscience and Pharmacology, Rudolf Magnus Institute of Neuroscience, UMC Utrecht, Utrecht, The Netherlands
Am J Med Genet B Neuropsychiatr Genet 153:960-6. 2010..247), which suggests that our findings should be interpreted with caution and indicates the need for studies that include large numbers of control subjects to ascertain the impact of these changes on a population scale... - Spatial and temporal expression of FoxO transcription factors in the developing and adult murine brainMarco F M Hoekman
Department of Pharmacology and Anatomy, Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, Universiteitsweg 100, 3584 CG Utrecht, The Netherlands
Gene Expr Patterns 6:134-40. 2006..5 and E14. In summary, the presented data show FoxO factors to be expressed in the adult and developing mouse brain, in a spatially end temporally restricted manner... - Sciatic nerve regeneration in mice and rats: recovery of sensory innervation is followed by a slowly retreating neuropathic pain-like syndromeChristina F Vogelaar
Rudolf Magnus Institute of Neuroscience, Department of Pharmacology and Anatomy, Universiteitsweg 100, 3584 CG Utrecht, The Netherlands
Brain Res 1027:67-72. 2004..The development of neuropathic pain following successful sensory recovery has not been described before in crush-lesioned animals and may provide an important new parameter to assess full sensory recovery... - The role of Munc18-1 in docking and exocytosis of peptide hormone vesicles in the anterior pituitaryNiki Korteweg
Molecular Neuroscience, Rudolf Magnus Institute, University of Utrecht, Utrecht, The Netherlands
Biol Cell 97:445-55. 2005..The soluble protein Munc18-1 is essential for synaptic vesicle secretion [Verhage, Maia, Plomp, Brussaard, Heeroma, Vermeer, Toonen, Hammer, van den Berg, Missler, et al. (2000) Science 287, 864-869.]... - Homeobox gene Pitx3 and its role in the development of dopamine neurons of the substantia nigraMarten P Smidt
Department of Pharmacology and Anatomy, Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, Universiteitsweg 100, 3584 CG, Utrecht, The Netherlands
Cell Tissue Res 318:35-43. 2004..Molecular analysis of the underlying mechanisms might provide new insights for understanding the selective degeneration observed in Parkinson patients... - Species differences in brain pre-pro-neurotensin/neuromedin N mRNA distribution: the expression pattern in mice resembles more closely that of primates than ratsSimone M Smits
Rudolf Magnus Institute of Neuroscience, Department of Pharmacology and Anatomy, University Medical Center Utrecht, Universiteitsweg 100, 3584 CG, The Netherlands
Brain Res Mol Brain Res 125:22-8. 2004..Moreover, these data indicate that the distribution in mice resembles most that of primates than rats... - Molecular mechanisms underlying midbrain dopamine neuron development and functionMarten P Smidt
Department of Pharmacology and Anatomy, Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, Universiteitsweg 100, 3584 CG, Utrecht, The Netherlands
Eur J Pharmacol 480:75-88. 2003..Finally, we analyse the potential of the mesencephalic dopaminergic system to adapt to gene dysfunction... - Molecular programming of stem cells into mesodiencephalic dopaminergic neuronsJ Peter H Burbach
Rudolf Magnus Institute of Neuroscience, Department of Pharmacology and Anatomy, University Medical Center Utrecht, PO Box 85060, 3508 AB Utrecht, The Netherlands
Trends Neurosci 29:601-3. 2006..Lmx1a also initiated a developmental program that drove an mdDA phenotype in mouse embryonic stem cells. This indicates that these factors can be exploited in cell-replacement strategies for treatment of Parkinson's disease... - A passport to neurotransmitter identityMarten P Smidt
Neuroscience and Pharmacology, University Medical Center Utrecht, Universiteitsweg 100, 3584 CG Utrecht, The Netherlands
Genome Biol 10:229. 2009..Comparison of a regulatory network that specifies dopaminergic neurons in Caenorhabditis elegans to the development of vertebrate dopamine systems in the mouse reveals a possible partial conservation of such a network... - Decreased thalamic expression of the homeobox gene DLX1 in psychosisMarjan Kromkamp
Department of Pharmacology, Rudolf Magnus Institute for Neurosciences, University Medical Center, Utrecht, The Netherlands
Arch Gen Psychiatry 60:869-74. 2003..CONCLUSION: Decreased thalamic expression of DLX1 in schizophrenia and bipolar disorder with psychosis suggests shared genetic deficits in expression of this homeobox gene... - Social Responsiveness Scale-aided analysis of the clinical impact of copy number variations in autismEmma van Daalen
Department of Child and Adolescent Psychiatry, University Medical Centre, Utrecht, The Netherlands
Neurogenetics 12:315-23. 2011..Our study extends the scope of genome-wide CNV profiling beyond de novo CNVs in sporadic patients and may aid in uncovering missing heritability in genome-wide screening studies of complex psychiatric disorders... - Endogenous cannabinoids are not involved in cocaine reinforcement and development of cocaine-induced behavioural sensitizationHeidi M B Lesscher
Department of Pharmacology and Anatomy, Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, Stratenum, Universiteitsweg 100, 3584 CG Utrecht, The Netherlands
Eur Neuropsychopharmacol 15:31-7. 2005..These findings suggest that CB1 receptors are not involved in acute cocaine reinforcement nor in cocaine-induced behavioural sensitization... - Gene-network analysis identifies susceptibility genes related to glycobiology in autismBert van der Zwaag
Department of Neuroscience and Pharmacology, Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, Utrecht, The Netherlands
PLoS ONE 4:e5324. 2009..Our findings suggest that the occurrence of genomic gains and losses of genes associated with glycobiology are important contributors to the development of ASD... - Transcription factors in the development of midbrain dopamine neuronsJ Peter H Burbach
Rudolf Magnus Institute of Neuroscience, Department of Pharmacology and Anatomy, University Medical Center Utrecht, Utrecht, The Netherlands
Ann N Y Acad Sci 991:61-8. 2003.... - Development of the mouse hypothalamo-neurohypophysial system in the munc18-1 null mutant that lacks regulated secretionNiki Korteweg
Rudolf Magnus Institute of Neuroscience, Department of Pharmacology and Anatomy, University Medical Centre Utrecht, Universiteitsweg 100, 3584 CG Utrecht, The Netherlands
Eur J Neurosci 19:2944-52. 2004..Thus, the communication between the outgrowing neurons and the pituicytes could serve to integrate these two cell types to constitute a functional peptidergic system... - How to make a mesodiencephalic dopaminergic neuronMarten P Smidt
Department of Pharmacology and Anatomy, Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, 3508 AB Utrecht corrected The Netherlands
Nat Rev Neurosci 8:21-32. 2007..Here, we follow the developmental path of these neurons with the goal of generating a molecular code that could be exploited in cell-replacement strategies to treat diseases such as Parkinson's disease... - In control of biology: of mice, men and FoxesPatrick J E C Wijchers
Rudolf Magnus Institute of Neuroscience, Department of Pharmacology and Anatomy, University Medical Center Utrecht, Universiteitsweg 100, 3584 CG Utrecht, The Netherlands
Biochem J 397:233-46. 2006..Finally, we will discuss how novel insights gained from involvement of 'Foxes' in the mechanisms underlying human pathology may create new opportunities for treatment strategies... - Cloning and analysis of the murine Foxi2 transcription factorPatrick J E C Wijchers
Rudolf Magnus Institute of Neuroscience, Department of Pharmacology and Anatomy, University Medical Center Utrecht, Universiteitsweg 100, 3584 CG Utrecht, The Netherlands
Biochim Biophys Acta 1731:133-8. 2005..Since FoxI factors are thought to be implicated in the regulation of cell fate, the highly restricted expression pattern of Foxi2 suggestive of a possible role in controlling cellular identity... - Homeobox gene expression in adult dorsal root ganglia during sciatic nerve regeneration: is regeneration a recapitulation of development?Christina F Vogelaar
Department of Pharmacology and Anatomy, Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, Universiteitsweg 100, 3584 CG, Utrecht, The Netherlands
Eur J Pharmacol 480:233-50. 2003..This mechanism may be the basis of pharmacological strategies to stimulate regeneration... - Copy-number variation in sporadic amyotrophic lateral sclerosis: a genome-wide screenHylke M Blauw
Department of Neurology, Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, Utrecht, Netherlands
Lancet Neurol 7:319-26. 2008.... - Mu-opioid receptors are not involved in acute cocaine-induced locomotor activity nor in development of cocaine-induced behavioral sensitization in miceHeidi M B Lesscher
Department of Pharmacology and Anatomy, Rudolf Magnus Institute of Neuroscience, UMC Utrecht, Stratenum, Universiteitsweg 100, Utrecht, The Netherlands
Neuropsychopharmacology 30:278-85. 2005..The present findings suggest that mu-opioid receptors are not required for the acute locomotor response to cocaine nor are they essential for the development of cocaine-induced behavioral sensitization... - CNS expression pattern of Lmx1b and coexpression with ptx genes suggest functional cooperativity in the development of forebrain motor control systemsCeriel H J Asbreuk
Rudolf Magnus Institute of Neuroscience, Department of Pharmacology and Anatomy, University Medical Center, Universiteitsweg 100, 3584 CG, Utrecht, The Netherlands
Mol Cell Neurosci 21:410-20. 2002..These data point to a combinatorial gene network that allows Lmx1b to diversify its regulatory actions by cooperation with specific Ptx genes... - U-SPECT-I: a novel system for submillimeter-resolution tomography with radiolabeled molecules in miceFreek J Beekman
Department of Nuclear Medicine, Image Sciences Institute, University Medical Center Utrecht, Utrecht, The Netherlands
J Nucl Med 46:1194-200. 2005..Here, we present a SPECT system (U-SPECT-I) dedicated to radionuclide imaging of murine organs at a submillimeter resolution... - FoxO6, a novel member of the FoxO class of transcription factors with distinct shuttling dynamicsFrank M J Jacobs
Rudolf Magnus Institute of Neuroscience, Department of Pharmacology and Anatomy, University Medical Center, Universiteitsweg 100, 3584 CG Utrecht, The Netherlands
J Biol Chem 278:35959-67. 2003..In conclusion, the data presented here gives a new view on regulation of FoxO-function through multiple phosphorylation events and other mechanisms involved in the nuclear exclusion of FoxO-proteins... - Contactins: structural aspects in relation to developmental functions in brain diseaseAmila Zuko
Department of Neuroscience and Pharmacology, Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, Utrecht, The Netherlands
Adv Protein Chem Struct Biol 84:143-80. 2011..The present data indicate that Cntn4, -5, and -6 proteins may be part of heteromeric receptor complexes as well as serve as ligands themselves... - Regulation of gene promoters of hypothalamic peptidesJ Peter H Burbach
Department of Pharmacology, Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, Universiteitsweg 100, 3584 CG Utrecht, The Netherlands
Front Neuroendocrinol 23:342-69. 2002..Others are essential to provide cell-specific expression of the peptidergic gene during development and mature regulation...