J P Burbach

Summary

Affiliation: University Medical Center Utrecht
Country: The Netherlands

Publications

  1. ncbi request reprint Genetic pathways in the developmental specification of hypothalamic neuropeptide and midbrain catecholamine systems
    J P Burbach
    Section of Molecular Neuroscience, Department of Medical Pharmacology, Rudolf Magnus Institute for Neurosciences, University Medical Center, Universiteitsweg 100, 3584 CG, Utrecht, The Netherlands
    Eur J Pharmacol 405:55-62. 2000
  2. ncbi request reprint [The 2004 Nobel Prize for Physiology or Medicine for research into smell receptors and the organization of the olfactory system]
    J P H Burbach
    Universitair Medisch Centrum Utrecht, Rudolf Magnus Instituut voor Neurowetenschappen, afd Farmacologie en Anatomie, Universiteitsweg 110, 3584 CG Utrecht
    Ned Tijdschr Geneeskd 148:2576-9. 2004
  3. ncbi request reprint Transcription factors in the development of midbrain dopamine neurons
    J Peter H Burbach
    Rudolf Magnus Institute of Neuroscience, Department of Pharmacology and Anatomy, University Medical Center Utrecht, Utrecht, The Netherlands
    Ann N Y Acad Sci 991:61-8. 2003
  4. ncbi request reprint Molecular programming of stem cells into mesodiencephalic dopaminergic neurons
    J Peter H Burbach
    Rudolf Magnus Institute of Neuroscience, Department of Pharmacology and Anatomy, University Medical Center Utrecht, PO Box 85060, 3508 AB Utrecht, The Netherlands
    Trends Neurosci 29:601-3. 2006
  5. ncbi request reprint Gene regulation in the magnocellular hypothalamo-neurohypophysial system
    J P Burbach
    Rudolf Magnus Institute for Neurosciences, Section of Molecular Neuroscience, Department of Medical Pharmacology, University Medical Center Utrecht, Utrecht, The Netherlands
    Physiol Rev 81:1197-267. 2001
  6. ncbi request reprint Analysis of three Ptx2 splice variants on transcriptional activity and differential expression pattern in the brain
    M P Smidt
    Section of Molecular Neuroscience, Department of Medical Pharmacology, Rudolf Magnus Institute for Neurosciences, Utrecht University Medical Center, Utrecht, The Netherlands
    J Neurochem 75:1818-25. 2000
  7. ncbi request reprint A second independent pathway for development of mesencephalic dopaminergic neurons requires Lmx1b
    M P Smidt
    Section of Molecular Neuroscience, Rudolf Magnus Institute for Neurosciences, Department of Medical Pharmacology, Medical Faculty, Utrecht University, Universiteitsweg 100, 3584 CG Utrecht, The Netherlands
    Nat Neurosci 3:337-41. 2000
  8. pmc A homeodomain gene Ptx3 has highly restricted brain expression in mesencephalic dopaminergic neurons
    M P Smidt
    Rudolf Magnus Institute for Neurosciences, Department of Medical Pharmacology, Medical Faculty, Utrecht University, The Netherlands
    Proc Natl Acad Sci U S A 94:13305-10. 1997
  9. ncbi request reprint Hypothalamic transcription factors and the regulation of the hypothalamo-neurohypophysial system
    J P Burbach
    Rudolf Magnus Institute for Neurosciences, Department of Medical Pharmacology, Utrecht University, The Netherlands
    Adv Exp Med Biol 449:29-37. 1998
  10. ncbi request reprint Delayed effect of the vasopressin metabolite VP4-8 on the social memory of sexually naive male rats
    L G Reijmers
    Rudolf Magnus Institute for Neurosciences, Utrecht University, Universiteitsweg 100, 3584 CG Utrecht, The Netherlands
    Psychopharmacology (Berl) 154:408-14. 2001

Collaborators

  • M P Smidt
  • B M Spruijt
  • L G Reijmers
  • H Chen
  • S M Luckman
  • J Drouin
  • S J Lolait
  • Richard Axel
  • D Murphy
  • H Gainer
  • R A Adan
  • M Nijenhuis
  • R L Johnson
  • Linda Buck
  • Marco F M Hoekman
  • Han G Brunner
  • J Graw
  • H B Uylings
  • M A F M Gerrits
  • Simone M Smits
  • Patrick J E C Wijchers
  • Bert van der Zwaag
  • Christina F Vogelaar
  • Frank M J Jacobs
  • Heidi M B Lesscher
  • Niki Korteweg
  • Annemarie J A van der Linden
  • George W Padberg
  • Hans van Bokhoven
  • Freek J Beekman
  • Jan M Van Ree
  • Matthijs Verhage
  • Ascanio S Maia
  • Marjan Kromkamp
  • Anita J C G M Hellemons
  • Ceriel H J Asbreuk
  • M Verhage
  • F Hernando
  • J Oosterom
  • N Korteweg
  • S Lopes da Silva
  • W H Gispen
  • Cornelle W Noorlander
  • Lars von Oerthel
  • Frans van der Have
  • Curt Scharfe
  • Brendan Vastenhouw
  • Geert M J Ramakers
  • Peter J Oefner
  • Emily Hoogveld
  • Daniel S Mathon
  • Michiel Hordijk
  • Eric W Roubos
  • Natalia P Bondar
  • Olga V Alekseyenko
  • Brenda Thompson
  • Peter P van Rijk
  • Jan H Brakkee
  • Frank P T Hamers
  • Dorien H Vrinten
  • H S van Schaick
  • Afke F Terwisscha van Scheltinga
  • Orla M Conneely
  • Lars P van der Heide
  • Tiia Ponnio
  • Willem Hendrik Gispen
  • Rene S Kahn
  • William P J Leenders
  • Anita Hellemons
  • G S Barsh
  • O Schoots
  • K M Garner
  • W A Nijenhuis
  • F A Denekamp
  • C A Kozak
  • M Luijten
  • S Asoh
  • H Røshol
  • A A Van Der Kleij
  • T C Sudhof
  • K J de Vries
  • A C Rovescalli
  • M Nirenberg
  • J J Cox
  • W Kruijer
  • L J Jonk
  • A M Van Horssen
  • C Chang

Detail Information

Publications48

  1. ncbi request reprint Genetic pathways in the developmental specification of hypothalamic neuropeptide and midbrain catecholamine systems
    J P Burbach
    Section of Molecular Neuroscience, Department of Medical Pharmacology, Rudolf Magnus Institute for Neurosciences, University Medical Center, Universiteitsweg 100, 3584 CG, Utrecht, The Netherlands
    Eur J Pharmacol 405:55-62. 2000
    ..Here, the genetic pathways enrolling in developing vasopressin, corticotropin-releasing hormone, and midbrain dopamine neurons are discussed...
  2. ncbi request reprint [The 2004 Nobel Prize for Physiology or Medicine for research into smell receptors and the organization of the olfactory system]
    J P H Burbach
    Universitair Medisch Centrum Utrecht, Rudolf Magnus Instituut voor Neurowetenschappen, afd Farmacologie en Anatomie, Universiteitsweg 110, 3584 CG Utrecht
    Ned Tijdschr Geneeskd 148:2576-9. 2004
    ....
  3. ncbi request reprint Transcription factors in the development of midbrain dopamine neurons
    J Peter H Burbach
    Rudolf Magnus Institute of Neuroscience, Department of Pharmacology and Anatomy, University Medical Center Utrecht, Utrecht, The Netherlands
    Ann N Y Acad Sci 991:61-8. 2003
    ....
  4. ncbi request reprint Molecular programming of stem cells into mesodiencephalic dopaminergic neurons
    J Peter H Burbach
    Rudolf Magnus Institute of Neuroscience, Department of Pharmacology and Anatomy, University Medical Center Utrecht, PO Box 85060, 3508 AB Utrecht, The Netherlands
    Trends Neurosci 29:601-3. 2006
    ..Lmx1a also initiated a developmental program that drove an mdDA phenotype in mouse embryonic stem cells. This indicates that these factors can be exploited in cell-replacement strategies for treatment of Parkinson's disease...
  5. ncbi request reprint Gene regulation in the magnocellular hypothalamo-neurohypophysial system
    J P Burbach
    Rudolf Magnus Institute for Neurosciences, Section of Molecular Neuroscience, Department of Medical Pharmacology, University Medical Center Utrecht, Utrecht, The Netherlands
    Physiol Rev 81:1197-267. 2001
    ..With the availability of several gene transfer approaches applicable to the HNS, it is anticipated that new insights will be obtained on how the HNS is able to respond to the physiological demands for its hormones...
  6. ncbi request reprint Analysis of three Ptx2 splice variants on transcriptional activity and differential expression pattern in the brain
    M P Smidt
    Section of Molecular Neuroscience, Department of Medical Pharmacology, Rudolf Magnus Institute for Neurosciences, Utrecht University Medical Center, Utrecht, The Netherlands
    J Neurochem 75:1818-25. 2000
    ..The data presented suggest that all variants of Ptx2 are involved in the development and regulation of distinct neuronal cell groups and the pituitary gland...
  7. ncbi request reprint A second independent pathway for development of mesencephalic dopaminergic neurons requires Lmx1b
    M P Smidt
    Section of Molecular Neuroscience, Rudolf Magnus Institute for Neurosciences, Department of Medical Pharmacology, Medical Faculty, Utrecht University, Universiteitsweg 100, 3584 CG Utrecht, The Netherlands
    Nat Neurosci 3:337-41. 2000
    ..The data suggest that at least two molecular cascades operate during the specification of the mesDA system, one specifying neurotransmitter phenotype and another essential for other aspects of mesDA neuron differentiation...
  8. pmc A homeodomain gene Ptx3 has highly restricted brain expression in mesencephalic dopaminergic neurons
    M P Smidt
    Rudolf Magnus Institute for Neurosciences, Department of Medical Pharmacology, Medical Faculty, Utrecht University, The Netherlands
    Proc Natl Acad Sci U S A 94:13305-10. 1997
    ..Thus, Ptx3 is a unique transcription factor marking the mesDA neurons at the exclusion of other dopaminergic neurons, and it may be involved in developmental determination of this neuronal lineage...
  9. ncbi request reprint Hypothalamic transcription factors and the regulation of the hypothalamo-neurohypophysial system
    J P Burbach
    Rudolf Magnus Institute for Neurosciences, Department of Medical Pharmacology, Utrecht University, The Netherlands
    Adv Exp Med Biol 449:29-37. 1998
    ..In this chapter two transcription factor families are considered: homeodomain proteins and nuclear receptors. Their identification in the hypothalamus and actions on the OT gene are addressed here...
  10. ncbi request reprint Delayed effect of the vasopressin metabolite VP4-8 on the social memory of sexually naive male rats
    L G Reijmers
    Rudolf Magnus Institute for Neurosciences, Utrecht University, Universiteitsweg 100, 3584 CG Utrecht, The Netherlands
    Psychopharmacology (Berl) 154:408-14. 2001
    ..It is concluded that in male rats sexual experience can influence the modulation of social memory by vasopressin...
  11. ncbi request reprint Vasopressin metabolites: a link between vasopressin and memory?
    L G Reijmers
    Rudolf Magnus Institute for Neurosciences, Department of Medical Pharmacology, Utrecht University, The Netherlands
    Prog Brain Res 119:523-35. 1998
    ..The VP metabolite receptor could be a link between the neuropeptide VP and memory-related behaviour...
  12. ncbi request reprint Social memory in the rat: circadian variation and effect of circadian rhythm disruption
    L G Reijmers
    Rudolf Magnus Institute for Neurosciences, Utrecht University, Universiteitsweg 100, 3584 CG Utrecht, Netherlands
    Physiol Behav 72:305-9. 2001
    ..Differences between short-term social memory and long-term passive avoidance memory are discussed in relation to their apparent differential susceptibility to the effects of circadian rhythm disruption...
  13. ncbi request reprint Immunohistochemical localization of the vasopressin V1b receptor in the rat brain and pituitary gland: anatomical support for its involvement in the central effects of vasopressin
    F Hernando
    Section of Molecular Science, Department of Medical Pharmacology, Rudolf Magnus Institute for Neurosciences, University Medical Center, 3584 CG Utrecht, The Netherlands
    Endocrinology 142:1659-68. 2001
    ..These data suggest that the V1bR mediates different physiological functions of VP in the brain...
  14. ncbi request reprint Different spatiotemporal expression of DOC2 genes in the developing rat brain argues for an additional, nonsynaptic role of DOC2B in early development
    N Korteweg
    Rudolf Magnus Institute for Neurosciences, Utrecht University, Universiteitsweg 100, 3584 CG Utrecht, The Netherlands
    Eur J Neurosci 12:165-71. 2000
    ....
  15. pmc Homeobox gene Prx3 expression in rodent brain and extraneural tissues
    H S van Schaick
    Rudolf Magnus Institute for Neurosciences, Department of Medical Pharmacology, Medical Faculty, Utrecht University, The Netherlands
    Proc Natl Acad Sci U S A 94:12993-8. 1997
    ..Prx3 may have a role in specifying neural systems involved in processing somatosensory information, as well as in face and body structure formation...
  16. ncbi request reprint Common requirements for melanocortin-4 receptor selectivity of structurally unrelated melanocortin agonist and endogenous antagonist, Agouti protein
    J Oosterom
    Department of Medical Pharmacology, Rudolf Magnus Institute for Neurosciences, University Medical Center Utrecht, P.O. Box 85060, 3508 AB Utrecht, The Netherlands
    J Biol Chem 276:931-6. 2001
    ..Thus, selectivity for structurally unrelated ligands with opposite activities is achieved in a similar manner for MC4R but not for MC3R...
  17. ncbi request reprint Long-term impairment of social memory in the rat after social defeat is not restored by desglycinamide-vasopressin
    L G Reijmers
    Rudolf Magnus Institute for Neurosciences, Department of Medical Pharmacology, Utrecht University, The, Utrecht, Netherlands
    Neurosci Lett 305:145-8. 2001
    ..It is concluded that social defeat followed by individual housing caused a long-term impairment of social memory, which was not restored by treatment with VP1-8...
  18. ncbi request reprint Mutations in the vasopressin prohormone involved in diabetes insipidus impair endoplasmic reticulum export but not sorting
    M Nijenhuis
    Department of Medical Pharmacology, Rudolf Magnus Institute for Neurosciences, Utrecht University, Universiteitsweg 100, 3584 CG Utrecht, The Netherlands
    J Biol Chem 274:21200-8. 1999
    ..Our data suggest that prolonged perturbation of the endoplasmic reticulum eventually leads to degeneration of neurons expressing mutant vasopressin prohormones, explaining the dominant nature of the disease...
  19. ncbi request reprint Localization of transcripts of the related nuclear orphan receptors COUP-TF I and ARP-1 in the adult mouse brain
    S Lopes da Silva
    Rudolf Magnus Institute for Neurosciences, Department of Medical Pharmacology, Utrecht University, The Netherlands
    Brain Res Mol Brain Res 30:131-6. 1995
    ..Lower amounts of ARP-1 transcripts were found in the anterior and lateral hypothalamic areas, in the suprachiasmatic nucleus, and in the choroid plexus.(ABSTRACT TRUNCATED AT 250 WORDS)..
  20. ncbi request reprint DOC2 proteins in rat brain: complementary distribution and proposed function as vesicular adapter proteins in early stages of secretion
    M Verhage
    Rudolf Magnus Institute for Neurosciences, University of Utrecht, The Netherlands
    Neuron 18:453-61. 1997
    ..These data suggest that DOC2 proteins are vesicular adapter proteins regulating munc18-syntaxin complexes and herewith synaptic vesicle docking...
  21. ncbi request reprint Expression of nuclear hormone receptors in the rat supraoptic nucleus
    S Lopes da Silva
    Rudolf Magnus Institute for Neurosciences, Department of Medical Pharmacology, Utrecht University, The Netherlands
    Endocrinology 136:2276-83. 1995
    ..This indicates that the peptide-producing magnocellular neurons of the SON express a specific set of transcription factors of the nuclear hormone receptor family...
  22. ncbi request reprint Retinoic acid counteracts developmental defects in the substantia nigra caused by Pitx3 deficiency
    Frank M J Jacobs
    Rudolf Magnus Institute of Neuroscience, Department of Pharmacology and Anatomy, University Medical Center Utrecht, Universiteitsweg 100, 3584 CG Utrecht, The Netherlands
    Development 134:2673-84. 2007
    ..Here, we propose a novel mechanism in which RA is involved in mdDA neuronal development and maintenance, providing new insights into subset-specific vulnerability in PD...
  23. ncbi request reprint Nucleotide variation analysis does not support a causal role for plexin-A1 in hereditary congenital facial paresis
    Bert van der Zwaag
    Department of Neurology, University Medical Centre Nijmegen, P O Box 9101, 6500 HB, Nijmegen, The Netherlands
    Brain Res Dev Brain Res 158:66-71. 2005
    ..We therefore conclude that it is highly unlikely that Plexin-A1 is involved in the pathogenicity of hereditary congenital facial paresis...
  24. ncbi request reprint Molecular and cellular alterations in the Pitx3-deficient midbrain dopaminergic system
    Simone M Smits
    Rudolf Magnus Institute of Neuroscience, Department of Pharmacology and Anatomy, University Medical Center Utrecht, Universiteitsweg 100, 3584 CG Utrecht, The Netherlands
    Mol Cell Neurosci 30:352-63. 2005
    ..In conclusion, ak mice display specific molecular and cellular alterations in the mDA system that provide new insights in compensatory mechanisms present in mDA-associated disorders such as PD...
  25. ncbi request reprint Spatial and temporal expression of FoxO transcription factors in the developing and adult murine brain
    Marco F M Hoekman
    Department of Pharmacology and Anatomy, Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, Universiteitsweg 100, 3584 CG Utrecht, The Netherlands
    Gene Expr Patterns 6:134-40. 2006
    ..5 and E14. In summary, the presented data show FoxO factors to be expressed in the adult and developing mouse brain, in a spatially end temporally restricted manner...
  26. ncbi request reprint Identification of forkhead transcription factors in cortical and dopaminergic areas of the adult murine brain
    Patrick J E C Wijchers
    Rudolf Magnus Institute of Neuroscience, Department of Pharmacology and Anatomy, University Medical Center Utrecht, Universiteitsweg 100, 3584 CG Utrecht, The Netherlands
    Brain Res 1068:23-33. 2006
    ..These forkhead transcription factors may play a role in maintenance and survival of developing and adult neurons...
  27. ncbi request reprint Developmental origin and fate of meso-diencephalic dopamine neurons
    Simone M Smits
    Rudolf Magnus Institute of Neuroscience, Department of Pharmacology and Anatomy, University Medical Center Utrecht, Universiteitsweg 100, 3584 CG Utrecht, The Netherlands
    Prog Neurobiol 78:1-16. 2006
    ..The data indicate that these specific subsets may explain the specific response of these neurons to toxins and genetic ablation...
  28. ncbi request reprint How to make a mesodiencephalic dopaminergic neuron
    Marten P Smidt
    Department of Pharmacology and Anatomy, Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, 3508 AB Utrecht corrected The Netherlands
    Nat Rev Neurosci 8:21-32. 2007
    ..Here, we follow the developmental path of these neurons with the goal of generating a molecular code that could be exploited in cell-replacement strategies to treat diseases such as Parkinson's disease...
  29. ncbi request reprint Homeobox gene Pitx3 and its role in the development of dopamine neurons of the substantia nigra
    Marten P Smidt
    Department of Pharmacology and Anatomy, Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, Universiteitsweg 100, 3584 CG, Utrecht, The Netherlands
    Cell Tissue Res 318:35-43. 2004
    ..Molecular analysis of the underlying mechanisms might provide new insights for understanding the selective degeneration observed in Parkinson patients...
  30. ncbi request reprint Species differences in brain pre-pro-neurotensin/neuromedin N mRNA distribution: the expression pattern in mice resembles more closely that of primates than rats
    Simone M Smits
    Rudolf Magnus Institute of Neuroscience, Department of Pharmacology and Anatomy, University Medical Center Utrecht, Universiteitsweg 100, 3584 CG, The Netherlands
    Brain Res Mol Brain Res 125:22-8. 2004
    ..Moreover, these data indicate that the distribution in mice resembles most that of primates than rats...
  31. ncbi request reprint Involvement of Nurr1 in specifying the neurotransmitter identity of ventral midbrain dopaminergic neurons
    Simone M Smits
    Rudolf Magnus Institute of Neuroscience, Department of Pharmacology and Anatomy, University Medical Center Utrecht, Universiteitsweg 100, 3584 CG Utrecht, The Netherlands
    Eur J Neurosci 18:1731-8. 2003
    ..5 and 14.5. Here we demonstrate that induction of VMAT2 and DAT specifically in mesDA neurons requires Nurr1 expression, whereas AADC expression in mesDA neurons is induced independently of Nurr1 function...
  32. ncbi request reprint FoxO6, a novel member of the FoxO class of transcription factors with distinct shuttling dynamics
    Frank M J Jacobs
    Rudolf Magnus Institute of Neuroscience, Department of Pharmacology and Anatomy, University Medical Center, Universiteitsweg 100, 3584 CG Utrecht, The Netherlands
    J Biol Chem 278:35959-67. 2003
    ..In conclusion, the data presented here gives a new view on regulation of FoxO-function through multiple phosphorylation events and other mechanisms involved in the nuclear exclusion of FoxO-proteins...
  33. ncbi request reprint Molecular mechanisms underlying midbrain dopamine neuron development and function
    Marten P Smidt
    Department of Pharmacology and Anatomy, Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, Universiteitsweg 100, 3584 CG, Utrecht, The Netherlands
    Eur J Pharmacol 480:75-88. 2003
    ..Finally, we analyse the potential of the mesencephalic dopaminergic system to adapt to gene dysfunction...
  34. ncbi request reprint CNS expression pattern of Lmx1b and coexpression with ptx genes suggest functional cooperativity in the development of forebrain motor control systems
    Ceriel H J Asbreuk
    Rudolf Magnus Institute of Neuroscience, Department of Pharmacology and Anatomy, University Medical Center, Universiteitsweg 100, 3584 CG, Utrecht, The Netherlands
    Mol Cell Neurosci 21:410-20. 2002
    ..These data point to a combinatorial gene network that allows Lmx1b to diversify its regulatory actions by cooperation with specific Ptx genes...
  35. ncbi request reprint Decreased thalamic expression of the homeobox gene DLX1 in psychosis
    Marjan Kromkamp
    Department of Pharmacology, Rudolf Magnus Institute for Neurosciences, University Medical Center, Utrecht, The Netherlands
    Arch Gen Psychiatry 60:869-74. 2003
    ..Homeobox genes involved in development and differentiation of the brain could play an important role in these disorders...
  36. ncbi request reprint Early developmental failure of substantia nigra dopamine neurons in mice lacking the homeodomain gene Pitx3
    Marten P Smidt
    Rudolf Magnus Institute of Neuroscience, Department of Pharmacology and Anatomy, University Medical Center, Universiteitsweg 100, 3584 CG Utrecht, The Netherlands
    Development 131:1145-55. 2004
    ..However, an overall lower activity was observed. The results suggest that Pitx3 is specifically required for the formation of the SNc subfield at the onset of dopaminergic neuron differentiation...
  37. ncbi request reprint PLEXIN-D1, a novel plexin family member, is expressed in vascular endothelium and the central nervous system during mouse embryogenesis
    Bert van der Zwaag
    Department of Neurology, University Medical Centre Nijmegen, Nijmegen, The Netherlands
    Dev Dyn 225:336-43. 2002
    ..Based on our results, we suggest that this expression of a member of the plexin family in vascular endothelium could point toward a role in embryonic vasculogenesis...
  38. ncbi request reprint Regulation of gene promoters of hypothalamic peptides
    J Peter H Burbach
    Department of Pharmacology, Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, Universiteitsweg 100, 3584 CG Utrecht, The Netherlands
    Front Neuroendocrinol 23:342-69. 2002
    ..Others are essential to provide cell-specific expression of the peptidergic gene during development and mature regulation...
  39. ncbi request reprint Development of the mouse hypothalamo-neurohypophysial system in the munc18-1 null mutant that lacks regulated secretion
    Niki Korteweg
    Rudolf Magnus Institute of Neuroscience, Department of Pharmacology and Anatomy, University Medical Centre Utrecht, Universiteitsweg 100, 3584 CG Utrecht, The Netherlands
    Eur J Neurosci 19:2944-52. 2004
    ..Thus, the communication between the outgrowing neurons and the pituicytes could serve to integrate these two cell types to constitute a functional peptidergic system...
  40. pmc In control of biology: of mice, men and Foxes
    Patrick J E C Wijchers
    Rudolf Magnus Institute of Neuroscience, Department of Pharmacology and Anatomy, University Medical Center Utrecht, Universiteitsweg 100, 3584 CG Utrecht, The Netherlands
    Biochem J 397:233-46. 2006
    ..Finally, we will discuss how novel insights gained from involvement of 'Foxes' in the mechanisms underlying human pathology may create new opportunities for treatment strategies...
  41. ncbi request reprint Cloning and analysis of the murine Foxi2 transcription factor
    Patrick J E C Wijchers
    Rudolf Magnus Institute of Neuroscience, Department of Pharmacology and Anatomy, University Medical Center Utrecht, Universiteitsweg 100, 3584 CG Utrecht, The Netherlands
    Biochim Biophys Acta 1731:133-8. 2005
    ..Since FoxI factors are thought to be implicated in the regulation of cell fate, the highly restricted expression pattern of Foxi2 suggestive of a possible role in controlling cellular identity...
  42. ncbi request reprint Mu-opioid receptors are not involved in acute cocaine-induced locomotor activity nor in development of cocaine-induced behavioral sensitization in mice
    Heidi M B Lesscher
    Department of Pharmacology and Anatomy, Rudolf Magnus Institute of Neuroscience, UMC Utrecht, Stratenum, Universiteitsweg 100, Utrecht, The Netherlands
    Neuropsychopharmacology 30:278-85. 2005
    ..The present findings suggest that mu-opioid receptors are not required for the acute locomotor response to cocaine nor are they essential for the development of cocaine-induced behavioral sensitization...
  43. ncbi request reprint U-SPECT-I: a novel system for submillimeter-resolution tomography with radiolabeled molecules in mice
    Freek J Beekman
    Department of Nuclear Medicine, Image Sciences Institute, University Medical Center Utrecht, Utrecht, The Netherlands
    J Nucl Med 46:1194-200. 2005
    ..Here, we present a SPECT system (U-SPECT-I) dedicated to radionuclide imaging of murine organs at a submillimeter resolution...
  44. ncbi request reprint Identifying new candidate genes for hereditary facial paresis on chromosome 3q21-q22 by RNA in situ hybridization in mouse
    Bert van der Zwaag
    Department of Neurology, University Medical Centre Nijmegen, 6500 HB Nijmegen, The Netherlands
    Genomics 86:55-67. 2005
    ....
  45. ncbi request reprint Homeobox gene expression in adult dorsal root ganglia during sciatic nerve regeneration: is regeneration a recapitulation of development?
    Christina F Vogelaar
    Department of Pharmacology and Anatomy, Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, Universiteitsweg 100, 3584 CG, Utrecht, The Netherlands
    Eur J Pharmacol 480:233-50. 2003
    ..This mechanism may be the basis of pharmacological strategies to stimulate regeneration...
  46. ncbi request reprint Endogenous cannabinoids are not involved in cocaine reinforcement and development of cocaine-induced behavioural sensitization
    Heidi M B Lesscher
    Department of Pharmacology and Anatomy, Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, Stratenum, Universiteitsweg 100, 3584 CG Utrecht, The Netherlands
    Eur Neuropsychopharmacol 15:31-7. 2005
    ..These findings suggest that CB1 receptors are not involved in acute cocaine reinforcement nor in cocaine-induced behavioural sensitization...
  47. ncbi request reprint Sciatic nerve regeneration in mice and rats: recovery of sensory innervation is followed by a slowly retreating neuropathic pain-like syndrome
    Christina F Vogelaar
    Rudolf Magnus Institute of Neuroscience, Department of Pharmacology and Anatomy, Universiteitsweg 100, 3584 CG Utrecht, The Netherlands
    Brain Res 1027:67-72. 2004
    ..The development of neuropathic pain following successful sensory recovery has not been described before in crush-lesioned animals and may provide an important new parameter to assess full sensory recovery...
  48. ncbi request reprint The role of Munc18-1 in docking and exocytosis of peptide hormone vesicles in the anterior pituitary
    Niki Korteweg
    Molecular Neuroscience, Rudolf Magnus Institute, University of Utrecht, Utrecht, The Netherlands
    Biol Cell 97:445-55. 2005
    ..The soluble protein Munc18-1 is essential for synaptic vesicle secretion [Verhage, Maia, Plomp, Brussaard, Heeroma, Vermeer, Toonen, Hammer, van den Berg, Missler, et al. (2000) Science 287, 864-869.]...