Miranda Buitenhuis

Summary

Affiliation: University Medical Center
Country: The Netherlands

Publications

  1. ncbi Signal transducer and activator of transcription 5 (STAT5)
    Miranda Buitenhuis
    Department of Pulmonary Diseases, G03 550, University Medical Center, Heidelberglaan 100, 3584 CX Utrecht, The Netherlands
    Int J Biochem Cell Biol 36:2120-4. 2004
  2. ncbi Protein kinase B (c-akt) regulates hematopoietic lineage choice decisions during myelopoiesis
    Miranda Buitenhuis
    Molecular Immunology Lab, Department of Immunology, University Medical Center, Utrecht, The Netherlands
    Blood 111:112-21. 2008
  3. ncbi p38 MAP kinase inhibits neutrophil development through phosphorylation of C/EBPalpha on serine 21
    Christian R Geest
    Molecular Immunology Lab, Department of Immunology, University Medical Center, Utrecht, The Netherlands
    Stem Cells 27:2271-82. 2009
  4. ncbi Differential regulation of granulopoiesis by the basic helix-loop-helix transcriptional inhibitors Id1 and Id2
    Miranda Buitenhuis
    Department of Pulmonary Diseases, University Medical Center, Utrecht, The Netherlands
    Blood 105:4272-81. 2005
  5. ncbi Ectopic expression of C/EBPalpha and ID1 is sufficient to restore defective neutrophil development in low-risk myelodysplasia
    Christian R Geest
    Department of Immunology, University Medical Center, Utrecht, The Netherlands
    Haematologica 94:1075-84. 2009
  6. ncbi Histone deacetylase inhibition modulates cell fate decisions during myeloid differentiation
    Marije Bartels
    Molecular Immunology Lab, Department of Immunology, University Medical Center, Lundlaan 6, 3584 EA Utrecht, The Netherlands
    Haematologica 95:1052-60. 2010
  7. ncbi Signal transducer and activator of transcription 5a (STAT5a) is required for eosinophil differentiation of human cord blood-derived CD34+ cells
    Miranda Buitenhuis
    Department of Pulmonary Diseases, University Medical Center, Utrecht, The Netherlands
    Blood 101:134-42. 2003
  8. ncbi Molecular mechanisms underlying FIP1L1-PDGFRA-mediated myeloproliferation
    Miranda Buitenhuis
    Molecular Immunology Lab, Department of Immunology, University Medical Center, Lundlaan 6, 3584 EA Utrecht, The Netherlands
    Cancer Res 67:3759-66. 2007
  9. ncbi Distinct patterns of hematopoietic stem cell involvement in acute lymphoblastic leukemia
    Anders Castor
    Hematopoietic Stem Cell Laboratory, Lund Strategic Research Center for Stem Cell Biology and Cell Therapy, 221 84 Lund, Sweden
    Nat Med 11:630-7. 2005
  10. ncbi Ligation of CD200R by CD200 is not required for normal murine myelopoiesis
    Eva S K Rijkers
    Department of Immunology, University Medical Centre Utrecht, Utrecht, The Netherlands
    Eur J Haematol 79:410-6. 2007

Collaborators

  • Paul J Coffer
  • Jan Cools
  • Christian R Geest
  • Marije Bartels
  • Edo Vellenga
  • Eva S K Rijkers
  • Anders Castor
  • Marc Bierings
  • Marrie C A Bruin
  • Marc B Bierings
  • Annemieke G Laarhoven
  • Henrike Veninga
  • Talitha de Ruiter
  • Robert M Hoek
  • Linde Meyaard
  • Stanislaw Garwicz
  • Kjeld Schmiegelow
  • Bertil Johansson
  • Carole Ramirez
  • Birgitte Lausen
  • Gunnar Juliusson
  • Sten Eirik W Jacobsen
  • Peter Hokland
  • Kristina Anderson
  • Lars Nilsson

Detail Information

Publications10

  1. ncbi Signal transducer and activator of transcription 5 (STAT5)
    Miranda Buitenhuis
    Department of Pulmonary Diseases, G03 550, University Medical Center, Heidelberglaan 100, 3584 CX Utrecht, The Netherlands
    Int J Biochem Cell Biol 36:2120-4. 2004
    ..Kinase inhibitors are currently being developed to negatively regulate STAT5 activity for clinical purposes...
  2. ncbi Protein kinase B (c-akt) regulates hematopoietic lineage choice decisions during myelopoiesis
    Miranda Buitenhuis
    Molecular Immunology Lab, Department of Immunology, University Medical Center, Utrecht, The Netherlands
    Blood 111:112-21. 2008
    ..These results identify an important novel role for PKB in regulation of cell fate choices during hematopoietic lineage commitment...
  3. ncbi p38 MAP kinase inhibits neutrophil development through phosphorylation of C/EBPalpha on serine 21
    Christian R Geest
    Molecular Immunology Lab, Department of Immunology, University Medical Center, Utrecht, The Netherlands
    Stem Cells 27:2271-82. 2009
    ..This signaling module may thus provide an important therapeutic target in the treatment of bone marrow failure...
  4. ncbi Differential regulation of granulopoiesis by the basic helix-loop-helix transcriptional inhibitors Id1 and Id2
    Miranda Buitenhuis
    Department of Pulmonary Diseases, University Medical Center, Utrecht, The Netherlands
    Blood 105:4272-81. 2005
    ..These data demonstrate that both Id1 and Id2 play a critical, although differential role in granulopoiesis...
  5. ncbi Ectopic expression of C/EBPalpha and ID1 is sufficient to restore defective neutrophil development in low-risk myelodysplasia
    Christian R Geest
    Department of Immunology, University Medical Center, Utrecht, The Netherlands
    Haematologica 94:1075-84. 2009
    ..Although a number of genetic defects in myelodysplastic progenitor cells have been described, the intracellular signaling pathways underlying aberrant regulation of myelopoiesis remain relatively undefined...
  6. ncbi Histone deacetylase inhibition modulates cell fate decisions during myeloid differentiation
    Marije Bartels
    Molecular Immunology Lab, Department of Immunology, University Medical Center, Lundlaan 6, 3584 EA Utrecht, The Netherlands
    Haematologica 95:1052-60. 2010
    ..Nonetheless, little is currently known concerning their effects on myelopoiesis...
  7. ncbi Signal transducer and activator of transcription 5a (STAT5a) is required for eosinophil differentiation of human cord blood-derived CD34+ cells
    Miranda Buitenhuis
    Department of Pulmonary Diseases, University Medical Center, Utrecht, The Netherlands
    Blood 101:134-42. 2003
    ..These results demonstrate that STAT5 plays a critical role in eosinophil differentiation of primary human hematopoietic cells...
  8. ncbi Molecular mechanisms underlying FIP1L1-PDGFRA-mediated myeloproliferation
    Miranda Buitenhuis
    Molecular Immunology Lab, Department of Immunology, University Medical Center, Lundlaan 6, 3584 EA Utrecht, The Netherlands
    Cancer Res 67:3759-66. 2007
    ....
  9. ncbi Distinct patterns of hematopoietic stem cell involvement in acute lymphoblastic leukemia
    Anders Castor
    Hematopoietic Stem Cell Laboratory, Lund Strategic Research Center for Stem Cell Biology and Cell Therapy, 221 84 Lund, Sweden
    Nat Med 11:630-7. 2005
    ....
  10. ncbi Ligation of CD200R by CD200 is not required for normal murine myelopoiesis
    Eva S K Rijkers
    Department of Immunology, University Medical Centre Utrecht, Utrecht, The Netherlands
    Eur J Haematol 79:410-6. 2007
    ..We conclude that CD200(-/-) mice exhibit normal myelopoiesis and that development of leukaemia in Dok-1/Dok-2 DKO mice is not caused by a lack of CD200-mediated CD200R signalling...