Rachel M Brouwer

Summary

Affiliation: University Medical Center Utrecht
Country: The Netherlands

Publications

  1. pmc White matter development in early puberty: a longitudinal volumetric and diffusion tensor imaging twin study
    Rachel M Brouwer
    Department of Psychiatry, Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, Utrecht, The Netherlands
    PLoS ONE 7:e32316. 2012
  2. doi request reprint Heritability of DTI and MTR in nine-year-old children
    Rachel M Brouwer
    Department of Psychiatry, Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, The Netherlands
    Neuroimage 53:1085-92. 2010
  3. doi request reprint Segmentation of MRI brain scans using non-uniform partial volume densities
    Rachel M Brouwer
    Rudolf Magnus Institute of Neuroscience, Department of Psychiatry, University Medical Center Utrecht, The Netherlands
    Neuroimage 49:467-77. 2010
  4. doi request reprint Overlapping and segregating structural brain abnormalities in twins with schizophrenia or bipolar disorder
    Hilleke E Hulshoff Pol
    Department of Psychiatry, Rudolf Magnus Institute for Neuroscience, University Medical Center Utrecht, The Netherlands
    Arch Gen Psychiatry 69:349-59. 2012
  5. doi request reprint Sex steroids and brain structure in pubertal boys and girls
    Jiska S Peper
    Rudolf Magnus Institute of Neuroscience, Department of Psychiatry, University Medical Center, Utrecht, The Netherlands
    Psychoneuroendocrinology 34:332-42. 2009
  6. doi request reprint Does having a twin brother make for a bigger brain?
    Jiska S Peper
    Department of Psychiatry, Rudolf Magnus Institute of Neuroscience, University Medical Center, Heidelberglaan 100, 3584 CX, Utrecht, The Netherlands
    Eur J Endocrinol 160:739-46. 2009
  7. doi request reprint Heritability of regional and global brain structure at the onset of puberty: a magnetic resonance imaging study in 9-year-old twin pairs
    Jiska S Peper
    Rudolf Magnus Institute of Neuroscience, Department of Psychiatry, University Medical Center, Utrecht, The Netherlands
    Hum Brain Mapp 30:2184-96. 2009
  8. doi request reprint Heritability of volumetric brain changes and height in children entering puberty
    Inge L C van Soelen
    Rudolf Magnus Institute of Neuroscience, Department of Psychiatry, University Medical Center Utrecht, Utrecht, The Netherlands
    Hum Brain Mapp 34:713-25. 2013
  9. pmc Focal and global brain measurements in siblings of patients with schizophrenia
    Heleen B M Boos
    Rudolf Magnus Institute of Neuroscience, Department of Psychiatry, University Medical Center Utrecht, The Netherlands
    Schizophr Bull 38:814-25. 2012
  10. doi request reprint Genetic and environmental influences on focal brain density in bipolar disorder
    Astrid C van der Schot
    Department of Psychiatry, University Medical Centre Utrecht, Heidelberglaan 100, Utrecht, The Netherlands
    Brain 133:3080-92. 2010

Detail Information

Publications17

  1. pmc White matter development in early puberty: a longitudinal volumetric and diffusion tensor imaging twin study
    Rachel M Brouwer
    Department of Psychiatry, Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, Utrecht, The Netherlands
    PLoS ONE 7:e32316. 2012
    ..In children who showed the most pronounced white matter growth, fractional anisotropy increased the least and vice-versa. Thus, white matter development in childhood may reflect a process of both expansion and fiber optimization...
  2. doi request reprint Heritability of DTI and MTR in nine-year-old children
    Rachel M Brouwer
    Department of Psychiatry, Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, The Netherlands
    Neuroimage 53:1085-92. 2010
    ....
  3. doi request reprint Segmentation of MRI brain scans using non-uniform partial volume densities
    Rachel M Brouwer
    Rudolf Magnus Institute of Neuroscience, Department of Psychiatry, University Medical Center Utrecht, The Netherlands
    Neuroimage 49:467-77. 2010
    ..In conclusion, we have presented a new partial volume segmentation algorithm that allows for comparisons over scanners and voxel sizes...
  4. doi request reprint Overlapping and segregating structural brain abnormalities in twins with schizophrenia or bipolar disorder
    Hilleke E Hulshoff Pol
    Department of Psychiatry, Rudolf Magnus Institute for Neuroscience, University Medical Center Utrecht, The Netherlands
    Arch Gen Psychiatry 69:349-59. 2012
    ..Although both disorders are characterized by changes in brain structure, family studies suggest more segregating than overlapping neuroanatomical abnormalities in both disorders...
  5. doi request reprint Sex steroids and brain structure in pubertal boys and girls
    Jiska S Peper
    Rudolf Magnus Institute of Neuroscience, Department of Psychiatry, University Medical Center, Utrecht, The Netherlands
    Psychoneuroendocrinology 34:332-42. 2009
    ..We suggest that in pubertal girls, estradiol may be implicated in neuronal changes in the cerebral cortex during this important period of brain development...
  6. doi request reprint Does having a twin brother make for a bigger brain?
    Jiska S Peper
    Department of Psychiatry, Rudolf Magnus Institute of Neuroscience, University Medical Center, Heidelberglaan 100, 3584 CX, Utrecht, The Netherlands
    Eur J Endocrinol 160:739-46. 2009
    ..For example, in litter-bearing mammals intrauterine position increases prenatal testosterone exposure through adjacent male fetuses, resulting in masculinization of brain morphology...
  7. doi request reprint Heritability of regional and global brain structure at the onset of puberty: a magnetic resonance imaging study in 9-year-old twin pairs
    Jiska S Peper
    Rudolf Magnus Institute of Neuroscience, Department of Psychiatry, University Medical Center, Utrecht, The Netherlands
    Hum Brain Mapp 30:2184-96. 2009
    ..Pubertal development may be directly involved in the decreases in gray matter areas that accompany the transition of our brains from childhood into adulthood...
  8. doi request reprint Heritability of volumetric brain changes and height in children entering puberty
    Inge L C van Soelen
    Rudolf Magnus Institute of Neuroscience, Department of Psychiatry, University Medical Center Utrecht, Utrecht, The Netherlands
    Hum Brain Mapp 34:713-25. 2013
    ..Brain and body each expand at their own pace and through separate genetic pathways. There are distinct genetic processes acting on structural brain development, which cannot be explained by genetic increase in height...
  9. pmc Focal and global brain measurements in siblings of patients with schizophrenia
    Heleen B M Boos
    Rudolf Magnus Institute of Neuroscience, Department of Psychiatry, University Medical Center Utrecht, The Netherlands
    Schizophr Bull 38:814-25. 2012
    ..This large magnetic resonance imaging study examined brain structures in patients with schizophrenia, their nonpsychotic siblings, and healthy control subjects using global and focal brain measurements...
  10. doi request reprint Genetic and environmental influences on focal brain density in bipolar disorder
    Astrid C van der Schot
    Department of Psychiatry, University Medical Centre Utrecht, Heidelberglaan 100, Utrecht, The Netherlands
    Brain 133:3080-92. 2010
    ....
  11. doi request reprint Exercise therapy, cardiorespiratory fitness and their effect on brain volumes: a randomised controlled trial in patients with schizophrenia and healthy controls
    Thomas W Scheewe
    Rudolf Magnus Institute of Neuroscience, Department of Psychiatry, University Medical Center Utrecht, Utrecht, The Netherlands
    Eur Neuropsychopharmacol 23:675-85. 2013
    ..However, cardiorespiratory fitness improvement attenuated brain volume changes in schizophrenia patients and increased thickness in large areas of the left cortex in both schizophrenia patients and healthy controls...
  12. doi request reprint Can structural MRI aid in clinical classification? A machine learning study in two independent samples of patients with schizophrenia, bipolar disorder and healthy subjects
    Hugo G Schnack
    Department of Psychiatry, Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, Utrecht, The Netherlands Electronic address
    Neuroimage 84:299-306. 2014
    ..The results also suggest that gray matter pathology in schizophrenia and bipolar disorder differs to such an extent that they can be reliably differentiated using machine learning paradigms. ..
  13. doi request reprint Mapping reliability in multicenter MRI: voxel-based morphometry and cortical thickness
    Hugo G Schnack
    Department of Psychiatry, Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, Utrecht, The Netherlands
    Hum Brain Mapp 31:1967-82. 2010
    ..g., around the thalamus). These tools will facilitate the design and analysis of multisite VBM and CORT studies for detecting group differences and estimating heritability...
  14. doi request reprint Family-wise automatic classification in schizophrenia
    Rene C W Mandl
    Department of Psychiatry, University Medical Center Utrecht, Rudolf Magnus Institute of Neuroscience, The Netherlands
    Schizophr Res 149:108-11. 2013
    ..54 to 0.72 using a support vector machine model. This inclusion of contextual information is especially useful in diseases where the classification features carry a heritable component. ..
  15. pmc Differential brain development with low and high IQ in attention-deficit/hyperactivity disorder
    Patrick de Zeeuw
    Neuroimaging Lab, Department of Child and Adolescent Psychiatry, Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, Utrecht, The Netherlands
    PLoS ONE 7:e35770. 2012
    ....
  16. doi request reprint Cerebral white matter in early puberty is associated with luteinizing hormone concentrations
    Jiska S Peper
    Rudolf Magnus Institute of Neuroscience, Department of Psychiatry, University Medical Center, Heidelberglaan 100, 3584 CX, Utrecht, The Netherlands
    Psychoneuroendocrinology 33:909-15. 2008
    ..In addition, genes involved in LH production may be promising candidate genes in neuropsychiatric illnesses with an onset in early adolescence...
  17. ncbi request reprint Genetic influences on human brain structure: a review of brain imaging studies in twins
    Jiska S Peper
    Department of Psychiatry, Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, A01 126, 3584 CX Utrecht, The Netherlands
    Hum Brain Mapp 28:464-73. 2007
    ..New techniques such as genome-wide scans may become helpful in the search for genes that are involved in the regulation of human brain volume throughout life...