Jan Leendert P Brouwer

Summary

Affiliation: University Hospital Groningen
Country: The Netherlands

Publications

  1. ncbi request reprint The contribution of inherited and acquired thrombophilic defects, alone or combined with antiphospholipid antibodies, to venous and arterial thromboembolism in patients with systemic lupus erythematosus
    Jan Leendert P Brouwer
    Division of Haemostasis, Thrombosis and Rheology, Department of Hematology, University Hospital Groningen The Netherlands
    Blood 104:143-8. 2004
  2. ncbi request reprint Difference in absolute risk of venous and arterial thrombosis between familial protein S deficiency type I and type III. Results from a family cohort study to assess the clinical impact of a laboratory test-based classification
    Jan Leendert P Brouwer
    Division of Haemostasis, Thrombosis and Rheology, Department of Haematology, University Hospital Groningen, 9713 GZ Groningen, The Netherlands
    Br J Haematol 128:703-10. 2005
  3. ncbi request reprint High risk of pregnancy-related venous thromboembolism in women with multiple thrombophilic defects
    Nienke Folkeringa
    Division of Haemostasis, Thrombosis and Rheology, Department of Haematology, University Medical Centre Groningen, Groningen, The Netherlands
    Br J Haematol 138:110-6. 2007
  4. doi request reprint Hereditary deficiency of protein C or protein S confers increased risk of arterial thromboembolic events at a young age: results from a large family cohort study
    Bakhtawar K Mahmoodi
    Division of Hemostasis, Thrombosis and Rheology, Department of Hematology, University Medical Center Groningen, Hanzeplein 1, 9713 GZ Groningen, The Netherlands
    Circulation 118:1659-67. 2008
  5. ncbi request reprint High long-term absolute risk of recurrent venous thromboembolism in patients with hereditary deficiencies of protein S, protein C or antithrombin
    Jan Leendert P Brouwer
    Division of Haemostasis, Thrombosis and Rheology, Department of Hematology, University Medical Center Groningen, Hanzeplein 1, 9713 GZ Groningen, The Netherlands
    Thromb Haemost 101:93-9. 2009
  6. ncbi request reprint Oral contraceptives and the absolute risk of venous thromboembolism in women with single or multiple thrombophilic defects: results from a retrospective family cohort study
    Elizabeth F W van Vlijmen
    Division of Haemostasis, Thrombosis and Rheology, Department of Hematology, University Medical Center Groningen, Hanzeplein 1, 9713 GZ Groningen, The Netherlands
    Arch Intern Med 167:282-9. 2007
  7. doi request reprint Selective testing for thrombophilia in patients with first venous thrombosis: results from a retrospective family cohort study on absolute thrombotic risk for currently known thrombophilic defects in 2479 relatives
    Willem M Lijfering
    Department of Hematology, University Medical Center Groningen, The Netherlands
    Blood 113:5314-22. 2009
  8. ncbi request reprint High absolute risks and predictors of venous and arterial thromboembolic events in patients with nephrotic syndrome: results from a large retrospective cohort study
    Bakhtawar K Mahmoodi
    Division of Hemostasis, Thrombosis, and Rheology, Department of Hematology, University Medical Center Groningen, Groningen, The Netherlands
    Circulation 117:224-30. 2008
  9. ncbi request reprint Contribution of multiple thrombophilic and transient risk factors in the development of cerebral venous thrombosis
    Eduard J Libourel
    Division of Haemostasis, Thrombosis and Rheology, Department of Haematology, University Medical Centre Groningen, Hanzeplein 1, 9713 GZ Groningen, The Netherlands
    Thromb Res 121:301-7. 2007
  10. ncbi request reprint Reduction of high fetal loss rate by anticoagulant treatment during pregnancy in antithrombin, protein C or protein S deficient women
    Nienke Folkeringa
    Division of Haemostasis, Thrombosis and Rheology, Department of Haematology, University Medical Centre Groningen, Groningen, The Netherlands
    Br J Haematol 136:656-61. 2007

Collaborators

Detail Information

Publications14

  1. ncbi request reprint The contribution of inherited and acquired thrombophilic defects, alone or combined with antiphospholipid antibodies, to venous and arterial thromboembolism in patients with systemic lupus erythematosus
    Jan Leendert P Brouwer
    Division of Haemostasis, Thrombosis and Rheology, Department of Hematology, University Hospital Groningen The Netherlands
    Blood 104:143-8. 2004
    ..In conclusion, factor V Leiden and the prothrombin mutation contribute to the risk of VTE in patients with SLE, and potentiate this risk when one of these thrombophilic defects are combined with LA and/or ACAs...
  2. ncbi request reprint Difference in absolute risk of venous and arterial thrombosis between familial protein S deficiency type I and type III. Results from a family cohort study to assess the clinical impact of a laboratory test-based classification
    Jan Leendert P Brouwer
    Division of Haemostasis, Thrombosis and Rheology, Department of Haematology, University Hospital Groningen, 9713 GZ Groningen, The Netherlands
    Br J Haematol 128:703-10. 2005
    ..This was because of lower free PS levels in type I deficient subjects and a free PS cut-off level far below the lower limit of its normal range...
  3. ncbi request reprint High risk of pregnancy-related venous thromboembolism in women with multiple thrombophilic defects
    Nienke Folkeringa
    Division of Haemostasis, Thrombosis and Rheology, Department of Haematology, University Medical Centre Groningen, Groningen, The Netherlands
    Br J Haematol 138:110-6. 2007
    ..In conclusion, women with hereditary deficiencies of antithrombin, protein C or protein S are at high risk of pregnancy-related venous thromboembolism. This risk is increased by multiple additional thrombophilic defects...
  4. doi request reprint Hereditary deficiency of protein C or protein S confers increased risk of arterial thromboembolic events at a young age: results from a large family cohort study
    Bakhtawar K Mahmoodi
    Division of Hemostasis, Thrombosis and Rheology, Department of Hematology, University Medical Center Groningen, Hanzeplein 1, 9713 GZ Groningen, The Netherlands
    Circulation 118:1659-67. 2008
    ....
  5. ncbi request reprint High long-term absolute risk of recurrent venous thromboembolism in patients with hereditary deficiencies of protein S, protein C or antithrombin
    Jan Leendert P Brouwer
    Division of Haemostasis, Thrombosis and Rheology, Department of Hematology, University Medical Center Groningen, Hanzeplein 1, 9713 GZ Groningen, The Netherlands
    Thromb Haemost 101:93-9. 2009
    ..This risk is increased after a first spontaneous event, and by concomitance of other thrombophilic defects...
  6. ncbi request reprint Oral contraceptives and the absolute risk of venous thromboembolism in women with single or multiple thrombophilic defects: results from a retrospective family cohort study
    Elizabeth F W van Vlijmen
    Division of Haemostasis, Thrombosis and Rheology, Department of Hematology, University Medical Center Groningen, Hanzeplein 1, 9713 GZ Groningen, The Netherlands
    Arch Intern Med 167:282-9. 2007
    ..The risk of venous thromboembolism (VTE) in women taking combined oral contraceptives (COCs) is attributed to changes in coagulation and fibrinolysis. Their impact may be greater in women with preexistent thrombophilic defects...
  7. doi request reprint Selective testing for thrombophilia in patients with first venous thrombosis: results from a retrospective family cohort study on absolute thrombotic risk for currently known thrombophilic defects in 2479 relatives
    Willem M Lijfering
    Department of Hematology, University Medical Center Groningen, The Netherlands
    Blood 113:5314-22. 2009
    ....
  8. ncbi request reprint High absolute risks and predictors of venous and arterial thromboembolic events in patients with nephrotic syndrome: results from a large retrospective cohort study
    Bakhtawar K Mahmoodi
    Division of Hemostasis, Thrombosis, and Rheology, Department of Hematology, University Medical Center Groningen, Groningen, The Netherlands
    Circulation 117:224-30. 2008
    ..We assessed the absolute risk of VTE and ATE in a large, single-center, retrospective cohort study and attempted to identify predictive factors in these patients...
  9. ncbi request reprint Contribution of multiple thrombophilic and transient risk factors in the development of cerebral venous thrombosis
    Eduard J Libourel
    Division of Haemostasis, Thrombosis and Rheology, Department of Haematology, University Medical Centre Groningen, Hanzeplein 1, 9713 GZ Groningen, The Netherlands
    Thromb Res 121:301-7. 2007
    ..We performed a study to identify differences in thrombotic risk profile, predisposing to CVT rather than DVT or PE, particularly the contribution of oral contraception and 11 thrombophilic defects...
  10. ncbi request reprint Reduction of high fetal loss rate by anticoagulant treatment during pregnancy in antithrombin, protein C or protein S deficient women
    Nienke Folkeringa
    Division of Haemostasis, Thrombosis and Rheology, Department of Haematology, University Medical Centre Groningen, Groningen, The Netherlands
    Br J Haematol 136:656-61. 2007
    ..07 (95% confidence interval 0.001-0.7; P = 0.02). Our data suggest that anticoagulant treatment during pregnancy reduces the high fetal loss rate in women with hereditary deficiencies of antithrombin, protein C or protein S...
  11. ncbi request reprint The risk of venous and arterial thrombosis in hyperhomocysteinemic subjects may be a result of elevated factor VIII levels
    Willem M Lijfering
    Division of Haemostasis, Thrombosis and Rheology, Department of Hematology, University Medical Center Groningen, Groningen, The Netherlands
    Haematologica 92:1703-6. 2007
    ..3 (CI 0.2-9.8) and no relatives had arterial thrombosis. We conclude that it is likely that the increased risk of venous and arterial thrombosis in hyperhomocysteinemia is mainly related to elevated FVIII levels...
  12. ncbi request reprint Development and validation of a health-related quality-of-life questionnaire in patients with yellow jacket allergy
    Joanne N G Oude Elberink
    Department of Allergology, University Hospital Groningen, The Netherlands
    J Allergy Clin Immunol 109:162-70. 2002
    ..The effects of an anaphylactic reaction after a yellow jacket sting on health-related quality of life (HRQL) have not been studied and are thus unknown...
  13. ncbi request reprint The pathogenesis of venous thromboembolism: evidence for multiple interrelated causes
    Jan Leendert P Brouwer
    University Medical Center Groningen, Groningen, The Netherlands
    Ann Intern Med 145:807-15. 2006
    ..Venous thromboembolism (VTE) is thought to result from interactions between multiple genetic and environmental risk factors...
  14. ncbi request reprint Identification of a novel PROS1 c.1113T-->GG frameshift mutation in a family with mixed type I/type III protein S deficiency
    Min Ki ten Kate
    Haematologica 91:1151-2. 2006
    ..All PS deficient subjects had increased protein C/S ratios as well as a novel PROS1 c.1113T-->GG frameshift mutation...