Hjalmar R Bouma

Summary

Affiliation: University Medical Center Groningen
Country: The Netherlands

Publications

  1. pmc Low body temperature governs the decline of circulating lymphocytes during hibernation through sphingosine-1-phosphate
    Hjalmar R Bouma
    Department of Clinical Pharmacology, Sections of Immunology and Membrane Cell Biology, University Medical Center Groningen, University of Groningen, 9713 AV Groningen, The Netherlands
    Proc Natl Acad Sci U S A 108:2052-7. 2011
  2. doi request reprint Blood cell dynamics during hibernation in the European Ground Squirrel
    H R Bouma
    Department of Clinical Pharmacology, Groningen University Institute for Drug Exploration GUIDE, University Medical Center Groningen, The Netherlands
    Vet Immunol Immunopathol 136:319-23. 2010
  3. doi request reprint Hibernation: the immune system at rest?
    Hjalmar R Bouma
    Department of Clinical Pharmacology, University Medical Center Groningen, University of Groningen, The Netherlands
    J Leukoc Biol 88:619-24. 2010
  4. doi request reprint AMP-activated protein kinase as a target for preconditioning in transplantation medicine
    Hjalmar R Bouma
    Department of Clinical Pharmacology, Groningen University Institute of Drug Exploration, University Medical Center Groningen, Groningen, The Netherlands
    Transplantation 90:353-8. 2010
  5. doi request reprint Induction of torpor: mimicking natural metabolic suppression for biomedical applications
    Hjalmar R Bouma
    Department of Clinical Pharmacology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    J Cell Physiol 227:1285-90. 2012
  6. pmc 5'-AMP impacts lymphocyte recirculation through activation of A2B receptors
    Hjalmar R Bouma
    University Medical Center Groningen, Antonius Deusinglaan 1, 9713 AV Groningen, The Netherlands
    J Leukoc Biol 94:89-98. 2013
  7. doi request reprint The role of endogenous H2S formation in reversible remodeling of lung tissue during hibernation in the Syrian hamster
    Fatemeh Talaei
    Department of Clinical Pharmacology, University of Groningen, University Medical Center Groningen, PO Box 196, 9700 RB Groningen, The Netherlands
    J Exp Biol 215:2912-9. 2012
  8. doi request reprint Reduction of body temperature governs neutrophil retention in hibernating and nonhibernating animals by margination
    Hjalmar R Bouma
    Department of Clinical Pharmacology, University Medical Center Groningen, The Netherlands
    J Leukoc Biol 94:431-7. 2013
  9. pmc Platelet dynamics during natural and pharmacologically induced torpor and forced hypothermia
    Edwin L de Vrij
    Department of Clinical Pharmacy and Pharmacology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands
    PLoS ONE 9:e93218. 2014
  10. pmc S1P1 receptor modulation preserves vascular function in mesenteric and coronary arteries after CPB in the rat independent of depletion of lymphocytes
    Iryna V Samarska
    Department of Anesthesiology, University of Groningen, University Medical Center Groningen, The Netherlands
    PLoS ONE 9:e97196. 2014

Collaborators

Detail Information

Publications16

  1. pmc Low body temperature governs the decline of circulating lymphocytes during hibernation through sphingosine-1-phosphate
    Hjalmar R Bouma
    Department of Clinical Pharmacology, Sections of Immunology and Membrane Cell Biology, University Medical Center Groningen, University of Groningen, 9713 AV Groningen, The Netherlands
    Proc Natl Acad Sci U S A 108:2052-7. 2011
    ....
  2. doi request reprint Blood cell dynamics during hibernation in the European Ground Squirrel
    H R Bouma
    Department of Clinical Pharmacology, Groningen University Institute for Drug Exploration GUIDE, University Medical Center Groningen, The Netherlands
    Vet Immunol Immunopathol 136:319-23. 2010
    ..5h after onset of arousal, even before body temperature is fully normalized...
  3. doi request reprint Hibernation: the immune system at rest?
    Hjalmar R Bouma
    Department of Clinical Pharmacology, University Medical Center Groningen, University of Groningen, The Netherlands
    J Leukoc Biol 88:619-24. 2010
    ..Unraveling the pathways that result in reduced immune function during hibernation will enhance our understanding of immunologic responses during extreme physiological changes in mammals...
  4. doi request reprint AMP-activated protein kinase as a target for preconditioning in transplantation medicine
    Hjalmar R Bouma
    Department of Clinical Pharmacology, Groningen University Institute of Drug Exploration, University Medical Center Groningen, Groningen, The Netherlands
    Transplantation 90:353-8. 2010
    ..AMPK activation before or during organ preservation might be a promising pharmacologic approach to limit organ injury and maintain graft quality before transplantation...
  5. doi request reprint Induction of torpor: mimicking natural metabolic suppression for biomedical applications
    Hjalmar R Bouma
    Department of Clinical Pharmacology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    J Cell Physiol 227:1285-90. 2012
    ..Elucidating the underlying mechanisms of natural and pharmacologically induced torpor will speed the development of new clinical approaches to treat a variety of trauma and stress states in humans...
  6. pmc 5'-AMP impacts lymphocyte recirculation through activation of A2B receptors
    Hjalmar R Bouma
    University Medical Center Groningen, Antonius Deusinglaan 1, 9713 AV Groningen, The Netherlands
    J Leukoc Biol 94:89-98. 2013
    ..In conclusion, 5'-AMP induces a state of pharmacological torpor in mice, during which, lymphopenia is governed primarily by body temperature-independent suppression of lymphocyte egress from LNs...
  7. doi request reprint The role of endogenous H2S formation in reversible remodeling of lung tissue during hibernation in the Syrian hamster
    Fatemeh Talaei
    Department of Clinical Pharmacology, University of Groningen, University Medical Center Groningen, PO Box 196, 9700 RB Groningen, The Netherlands
    J Exp Biol 215:2912-9. 2012
    ..Although administration of H(2)S is known to induce metabolic suppression in non-hibernating mammals ('suspended animation'), this is the first report implying endogenous H(2)S production in natural hibernation...
  8. doi request reprint Reduction of body temperature governs neutrophil retention in hibernating and nonhibernating animals by margination
    Hjalmar R Bouma
    Department of Clinical Pharmacology, University Medical Center Groningen, The Netherlands
    J Leukoc Biol 94:431-7. 2013
    ..These findings may be of clinical relevance, as they could explain, at in least part, the benefits and drawbacks of therapeutic hypothermia as used in trauma patients and during major surgery. ..
  9. pmc Platelet dynamics during natural and pharmacologically induced torpor and forced hypothermia
    Edwin L de Vrij
    Department of Clinical Pharmacy and Pharmacology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands
    PLoS ONE 9:e93218. 2014
    ..Possibly, margination of platelets, dependent on intrinsic platelet functionality, governs clearance of circulating platelets during torpor. ..
  10. pmc S1P1 receptor modulation preserves vascular function in mesenteric and coronary arteries after CPB in the rat independent of depletion of lymphocytes
    Iryna V Samarska
    Department of Anesthesiology, University of Groningen, University Medical Center Groningen, The Netherlands
    PLoS ONE 9:e97196. 2014
    ..Sphingosine 1-phosphate (S1P) modulates various vascular and immune responses. Here we explored whether agonists of the S1P receptors, FTY720 and SEW2871 improve vascular reactivity after CPB in the rat...
  11. doi request reprint Hibernation is associated with depression of T-cell independent humoral immune responses in the 13-lined ground squirrel
    Hjalmar R Bouma
    Department of Clinical Pharmacology, University of Groningen, University Medical Center Groningen, A Deusinglaan 1, Groningen, The Netherlands
    Dev Comp Immunol 39:154-60. 2013
    ..These results demonstrate that hibernation diminishes the capacity to induce a TI-2 humoral immune response, while the capacity to induce a humoral response to a TD antigen is maintained...
  12. doi request reprint Microarray analysis of gene expression profiles in the rat kidney demonstrates a local inflammatory response induced by cardiopulmonary bypass
    Hjalmar R Bouma
    Department of Clinical Pharmacology, University Medical Center Groningen, Groningen, The Netherlands
    Eur J Anaesthesiol 30:492-500. 2013
    ..Cardiopulmonary bypass (CPB) is a commonly used technique in cardiac surgery but is associated with acute, transient, renal dysfunction that has a negative impact on long-term survival...
  13. pmc Serotonin and dopamine protect from hypothermia/rewarming damage through the CBS/H2S pathway
    Fatemeh Talaei
    Department of Clinical Pharmacology FB20, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    PLoS ONE 6:e22568. 2011
    ..Our data identify a novel molecular link between biogenic amines and the H(2)S pathway, which may profoundly affect our understanding of the biological effects of monoamine neurotransmitters...
  14. doi request reprint Troubleshooting the rat model of cardiopulmonary bypass: effects of avoiding blood transfusion on long-term survival, inflammation and organ damage
    Iryna V Samarska
    Dept of Anesthesiology, University Medical Centre Groningen, University of Groningen, The Netherlands
    J Pharmacol Toxicol Methods 67:82-90. 2013
    ....
  15. pmc The role of coronary artery calcification score in clinical practice
    Lieuwe H Piers
    Department of Cardiology, University Medical Center Groningen, Groningen, The Netherlands
    BMC Cardiovasc Disord 8:38. 2008
    ..We sought to evaluate the impact of the CAC score in the diagnostic process immediately after its introduction in a large tertiary referral centre...
  16. doi request reprint Reversible remodeling of lung tissue during hibernation in the Syrian hamster
    Fatemeh Talaei
    Department of Clinical Pharmacology, University Medical Center Groningen, University of Groningen, PO Box 196, 9700 RB Groningen, The Netherlands
    J Exp Biol 214:1276-82. 2011
    ....