Hjalmar R Bouma

Summary

Affiliation: University Medical Center Groningen
Country: The Netherlands

Publications

  1. ncbi Low body temperature governs the decline of circulating lymphocytes during hibernation through sphingosine-1-phosphate
    Hjalmar R Bouma
    Department of Clinical Pharmacology, Sections of Immunology and Membrane Cell Biology, University Medical Center Groningen, University of Groningen, 9713 AV Groningen, The Netherlands
    Proc Natl Acad Sci U S A 108:2052-7. 2011
  2. ncbi Blood cell dynamics during hibernation in the European Ground Squirrel
    H R Bouma
    Department of Clinical Pharmacology, Groningen University Institute for Drug Exploration GUIDE, University Medical Center Groningen, The Netherlands
    Vet Immunol Immunopathol 136:319-23. 2010
  3. ncbi Hibernation: the immune system at rest?
    Hjalmar R Bouma
    Department of Clinical Pharmacology, University Medical Center Groningen, University of Groningen, The Netherlands
    J Leukoc Biol 88:619-24. 2010
  4. ncbi AMP-activated protein kinase as a target for preconditioning in transplantation medicine
    Hjalmar R Bouma
    Department of Clinical Pharmacology, Groningen University Institute of Drug Exploration, University Medical Center Groningen, Groningen, The Netherlands
    Transplantation 90:353-8. 2010
  5. ncbi Induction of torpor: mimicking natural metabolic suppression for biomedical applications
    Hjalmar R Bouma
    Department of Clinical Pharmacology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    J Cell Physiol 227:1285-90. 2012
  6. ncbi The role of endogenous H2S formation in reversible remodeling of lung tissue during hibernation in the Syrian hamster
    Fatemeh Talaei
    Department of Clinical Pharmacology, University of Groningen, University Medical Center Groningen, PO Box 196, 9700 RB Groningen, The Netherlands
    J Exp Biol 215:2912-9. 2012
  7. ncbi Serotonin and dopamine protect from hypothermia/rewarming damage through the CBS/H2S pathway
    Fatemeh Talaei
    Department of Clinical Pharmacology FB20, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    PLoS ONE 6:e22568. 2011
  8. ncbi The role of coronary artery calcification score in clinical practice
    Lieuwe H Piers
    Department of Cardiology, University Medical Center Groningen, Groningen, The Netherlands
    BMC Cardiovasc Disord 8:38. 2008
  9. ncbi Hibernation is associated with depression of T-cell independent humoral immune responses in the 13-lined ground squirrel
    Hjalmar R Bouma
    Department of Clinical Pharmacology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands Electronic address
    Dev Comp Immunol 39:154-60. 2013
  10. ncbi Reversible remodeling of lung tissue during hibernation in the Syrian hamster
    Fatemeh Talaei
    Department of Clinical Pharmacology, University Medical Center Groningen, University of Groningen, PO Box 196, 9700 RB Groningen, The Netherlands
    J Exp Biol 214:1276-82. 2011

Detail Information

Publications11

  1. ncbi Low body temperature governs the decline of circulating lymphocytes during hibernation through sphingosine-1-phosphate
    Hjalmar R Bouma
    Department of Clinical Pharmacology, Sections of Immunology and Membrane Cell Biology, University Medical Center Groningen, University of Groningen, 9713 AV Groningen, The Netherlands
    Proc Natl Acad Sci U S A 108:2052-7. 2011
    ....
  2. ncbi Blood cell dynamics during hibernation in the European Ground Squirrel
    H R Bouma
    Department of Clinical Pharmacology, Groningen University Institute for Drug Exploration GUIDE, University Medical Center Groningen, The Netherlands
    Vet Immunol Immunopathol 136:319-23. 2010
    ..5h after onset of arousal, even before body temperature is fully normalized...
  3. ncbi Hibernation: the immune system at rest?
    Hjalmar R Bouma
    Department of Clinical Pharmacology, University Medical Center Groningen, University of Groningen, The Netherlands
    J Leukoc Biol 88:619-24. 2010
    ..Unraveling the pathways that result in reduced immune function during hibernation will enhance our understanding of immunologic responses during extreme physiological changes in mammals...
  4. ncbi AMP-activated protein kinase as a target for preconditioning in transplantation medicine
    Hjalmar R Bouma
    Department of Clinical Pharmacology, Groningen University Institute of Drug Exploration, University Medical Center Groningen, Groningen, The Netherlands
    Transplantation 90:353-8. 2010
    ..AMPK activation before or during organ preservation might be a promising pharmacologic approach to limit organ injury and maintain graft quality before transplantation...
  5. ncbi Induction of torpor: mimicking natural metabolic suppression for biomedical applications
    Hjalmar R Bouma
    Department of Clinical Pharmacology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    J Cell Physiol 227:1285-90. 2012
    ..Elucidating the underlying mechanisms of natural and pharmacologically induced torpor will speed the development of new clinical approaches to treat a variety of trauma and stress states in humans...
  6. ncbi The role of endogenous H2S formation in reversible remodeling of lung tissue during hibernation in the Syrian hamster
    Fatemeh Talaei
    Department of Clinical Pharmacology, University of Groningen, University Medical Center Groningen, PO Box 196, 9700 RB Groningen, The Netherlands
    J Exp Biol 215:2912-9. 2012
    ..Although administration of H(2)S is known to induce metabolic suppression in non-hibernating mammals ('suspended animation'), this is the first report implying endogenous H(2)S production in natural hibernation...
  7. ncbi Serotonin and dopamine protect from hypothermia/rewarming damage through the CBS/H2S pathway
    Fatemeh Talaei
    Department of Clinical Pharmacology FB20, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    PLoS ONE 6:e22568. 2011
    ..Our data identify a novel molecular link between biogenic amines and the H(2)S pathway, which may profoundly affect our understanding of the biological effects of monoamine neurotransmitters...
  8. ncbi The role of coronary artery calcification score in clinical practice
    Lieuwe H Piers
    Department of Cardiology, University Medical Center Groningen, Groningen, The Netherlands
    BMC Cardiovasc Disord 8:38. 2008
    ..We sought to evaluate the impact of the CAC score in the diagnostic process immediately after its introduction in a large tertiary referral centre...
  9. ncbi Hibernation is associated with depression of T-cell independent humoral immune responses in the 13-lined ground squirrel
    Hjalmar R Bouma
    Department of Clinical Pharmacology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands Electronic address
    Dev Comp Immunol 39:154-60. 2013
    ..These results demonstrate that hibernation diminishes the capacity to induce a TI-2 humoral immune response, while the capacity to induce a humoral response to a TD antigen is maintained...
  10. ncbi Reversible remodeling of lung tissue during hibernation in the Syrian hamster
    Fatemeh Talaei
    Department of Clinical Pharmacology, University Medical Center Groningen, University of Groningen, PO Box 196, 9700 RB Groningen, The Netherlands
    J Exp Biol 214:1276-82. 2011
    ....
  11. ncbi Troubleshooting the rat model of cardiopulmonary bypass: effects of avoiding blood transfusion on long-term survival, inflammation and organ damage
    Iryna V Samarska
    Dept of Anesthesiology, University Medical Centre Groningen, University of Groningen, The Netherlands
    J Pharmacol Toxicol Methods 67:82-90. 2013
    ....