R W B Bottema

Summary

Affiliation: University Medical Center Groningen
Country: The Netherlands

Publications

  1. ncbi Phenotype definition, age, and gender in the genetics of asthma and atopy
    R W B Bottema
    Department of Pulmonology, University Medical Center Groningen, University of Groningen, Hanzeplein 1, Groningen 9700 RB, The Netherlands
    Immunol Allergy Clin North Am 25:621-39. 2005
  2. doi X-chromosome Forkhead Box P3 polymorphisms associate with atopy in girls in three Dutch birth cohorts
    R W B Bottema
    Department of Pulmonology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    Allergy 65:865-74. 2010
  3. doi TLR-related pathway analysis: novel gene-gene interactions in the development of asthma and atopy
    N E Reijmerink
    Department of Pulmonology, University Medical Center Groningen, University of Groningen, The Netherlands
    Allergy 65:199-207. 2010
  4. doi Toll-like receptors and microbial exposure: gene-gene and gene-environment interaction in the development of atopy
    N E Reijmerink
    Department of Pulmonology, University Medical Center Groningen, Groningen, The Netherlands
    Eur Respir J 38:833-40. 2011
  5. doi Interaction of T-cell and antigen presenting cell co-stimulatory genes in childhood IgE
    R W B Bottema
    Dept of Pulmonology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    Eur Respir J 35:54-63. 2010
  6. doi Interleukin 13, CD14, pet and tobacco smoke influence atopy in three Dutch cohorts: the allergenic study
    R W B Bottema
    Dept of Pulmonology, University Medical Center Groningen, P O Box 196, 9700 AD Groningen, The Netherlands
    Eur Respir J 32:593-602. 2008

Collaborators

Detail Information

Publications6

  1. ncbi Phenotype definition, age, and gender in the genetics of asthma and atopy
    R W B Bottema
    Department of Pulmonology, University Medical Center Groningen, University of Groningen, Hanzeplein 1, Groningen 9700 RB, The Netherlands
    Immunol Allergy Clin North Am 25:621-39. 2005
    ..To acquire sufficient power for these types of analyses, international collaboration may be the only way to elucidate the intricate, gene-environmental interactions in atopy and asthma in an age- and gender-dependent manor...
  2. doi X-chromosome Forkhead Box P3 polymorphisms associate with atopy in girls in three Dutch birth cohorts
    R W B Bottema
    Department of Pulmonology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    Allergy 65:865-74. 2010
    ..Regulatory T cells may suppress development of atopy. We evaluated whether single-nucleotide polymorphisms (SNPs) of FOXP3 are associated with atopy development in childhood...
  3. doi TLR-related pathway analysis: novel gene-gene interactions in the development of asthma and atopy
    N E Reijmerink
    Department of Pulmonology, University Medical Center Groningen, University of Groningen, The Netherlands
    Allergy 65:199-207. 2010
    ..Numerous studies have shown associations of TLR-related pathway genes with asthma and atopy phenotypes. So far it has not been investigated whether gene-gene interactions in this pathway contribute to atopy and asthma development...
  4. doi Toll-like receptors and microbial exposure: gene-gene and gene-environment interaction in the development of atopy
    N E Reijmerink
    Department of Pulmonology, University Medical Center Groningen, Groningen, The Netherlands
    Eur Respir J 38:833-40. 2011
    ..Furthermore, complex two- and three-factor interactions exist between genes and the environment. The TLRs and related genes interact with proxy parameters of high microbial exposure in atopy development...
  5. doi Interaction of T-cell and antigen presenting cell co-stimulatory genes in childhood IgE
    R W B Bottema
    Dept of Pulmonology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    Eur Respir J 35:54-63. 2010
    ..In conclusion, serum IgE levels are regulated by multiple gene-gene interaction effects in the co-stimulatory pathway. We suggest using research strategies that model multiple gene-gene interactions in genetic studies...
  6. doi Interleukin 13, CD14, pet and tobacco smoke influence atopy in three Dutch cohorts: the allergenic study
    R W B Bottema
    Dept of Pulmonology, University Medical Center Groningen, P O Box 196, 9700 AD Groningen, The Netherlands
    Eur Respir J 32:593-602. 2008
    ..Additionally, pooled data improved effect estimates and genetic effects could be detected in interaction with important environmental factors...